Department of Medicine

Toxic Granulation

Toxic granulation

When a patient has an infection or a severe inflammatory disorder there is an increase in the neutrophil count (neutrophil leucocytosis or neutrophilia) and the neutrophils also show toxic granulation - coarse granules which are more deeply coloured than normal (compare with Slide 1).Less common changes in the neutrophil in response to infection are vacuolation of the cytoplasm (the most specific sign of bacterial infection) and Dohle bodies. Dohle bodies are inconspicuous greyish-blue areas in the cytoplasm which represent residual ribosomes. It should be noted that 'toxic granulation' also occurs in normal pregnancy as well as in infection and inflammation.

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