Department of Medicine

Publications

1. Simultaneous non-contact topography and electrochemical imaging by SECM/SICM featuring ion current feedback regulation (2010) Y Takahashi, A Shevchuk, P Novak, Y Murakami, H Shiku, Y Korchev, T Matsue JACS (accepted for publication)
2. V Nikolaev, A Moshkov, A Lyon, M Miragoli, P Novak, H Paur, M Lohse, Y Korchev, S Harding, J Gorelik (2010) Redistribution of ß2 adrenergic receptors leads to changes in camp compartmentation in heart failure. Science 327: 1653-1657.
3. J. Adler, A. I. Shevchuk, P. Novak, Y. E. Korchev, I. Parmryd. (2010) High Resolution Plasma Membrane Topography Imaging for Correct Interpretation of Single Particle Tracks. Nature Meth. 7: 170-171.
4. Sviderskaya, E.V., Easty, D.J., Lawrence, M.A., Sánchez, D., Negulyaev, Y.A., Patel, R.H., Anand, P., Korchev, Y.E. and Bennett, D.C. (2009) Functional neurons and melanocytes induced from immortal lines of postnatal neural crest-like stem cells. FASEB J 23:3179-3192
5. Alexander R. Lyon, Ken Macleod, Yanjun Zhang, Edwin Garcia, Gaelle Kikonda Kanda, Max Lab, Yuri Korchev, Sian E. Harding and Julia Gorelik. (2009) Loss of T-tubules and other changes to surface topography in ventricular myocytes from failing human and rat heart. Proc. Natl. Acad. Sci. U.S.A 106: 6854-6859
6. Banfic H, Visnjic D, Mise N, Balakrishnan S, Deplano S, Korchev YE, Domin J. (2009) Epidermal growth factor stimulates translocation of the class II phosphoinositide 3-kinase PI3K-C2beta to the nucleus. Biochem J. 422(1):53-60.
7. Pavel Novak, Chao Li, Andrew I. Shevchuk, Ruben Stepanyan, Matthew Caldwell, Simon Hughes, Trevor G. Smart, Julia Gorelik, Victor P. Ostanin, Max J. Lab, Guy W. J. Moss, Gregory I. Frolenkov, David Klenerman and Yuri E. Korchev. (2009) Nanoscale live cell imaging using hopping probe ion conductance microscopy. Nature Meth. 6: 279-281
8. U. Anand, W. Otto, D. Sanchez-Herrera, P. Facer, Y. Yiangou, Y. Korchev, R. Birch, C. Benham, C. Bountra, I. Chessell. (2008) Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neurons. Pain, 138 (3): 667-680
9. J Gorelik, N Ali, S Kadir, M Lab, P Stojkovic, L Armstrong, E Sviderskaya, Y Negulyaev, D Klenerman, D Bennett, M Lako, S Harding, M Stojkovic and Y Korchev. (2008) Non-invasive imaging of Stem Cells by Scanning ion conductance microscopy: future perspective. Tissue Eng., 14: 311-318
10. Joe D. Pipe, Chao Li, Chien-Jung Lo, Richard Berry, Yuri Korchev, Liming Ying and David Klenerman (2008) Characterization and Application of Controllable Local Chemical Changes Produced by Reagent Delivery from a Nanopipet J. Am. Chem. Soc., 130 (31): 10386–10393
11. Chao Li, Nicholas Johnson, Victor Ostanin, Andrew Shevchuk, Liming Ying, Yuri Korchev and David Klenerman. (2008) High resolution imaging using scanning ion conductance microscopy with improved distance feedback control. Prog Nat Sci., 18(6): 671-677
12. Kemp, S. J., A. J. Thorley, J. Gorelik, M. J. Seckl, M. J. O'Hare, A. Arcaro, Y. Korchev, P. Goldstraw, and T. D. Tetley. 2008. Immortalisation of Human Alveolar Epithelial Cells to Investigate Nanoparticle Uptake. Am. J. Respir. Cell Mol. Biol. 39(5):591-597
13. Sanchez, D., N. Johnson, C. Li, P. Novak, J. Rheinlaender, Y. Zhang, U. Anand, P. Anand, J. Gorelik, G. Frolenkov, C. Benham, M. Lab, V. Ostanin, T. E. Schaffer, D. Klenerman, and Y. Korchev. 2008. Non-contact measurement of the local mechanical properties of living cells using pressure applied via a pipette. Biophys. J. 95(6): 3017-3027
14. Shevchuk, A. I., P. Hobson, M. J. Lab, D. Klenerman, N. Krauzewicz, and Y. E. Korchev. 2008. Imaging single virus particles on the surface of cell membranes by high-resolution scanning surface confocal microscopy. Biophys. J. 94:4089-4094.
15. Shevchuk, A. I., P. Hobson, M. J. Lab, D. Klenerman, N. Krauzewicz, and Y. E. Korchev. 2008. Endocytic pathways: combined scanning ion conductance and surface confocal microscopy study. Pflugers Arch. 456:227-235.
16. Dutta, A. K., Y. E. Korchev, A. I. Shevchuk, S. Hayashi, Y. Okada, and R. Z. Sabirov. 2008. Spatial distribution of maxi-anion channel on cardiomyocytes detected by smart-patch technique. Biophys. J. 94:1646-1655.
17. Bruckbauer, A., P. James, D. Zhou, J. W. Yoon, D. Excell, Y. Korchev, R. Jones, and D. Klenerman. 2007. Nanopipette delivery of individual molecules to cellular compartments for single-molecule fluorescence tracking. Biophys. J. 93:3120-3131.
18. Zhang, Y., D. Sanchez, J. Gorelik, D. Klenerman, M. Lab, C. Edwards, and Y. Korchev. 2007. Basolateral P2X4-like receptors regulate the extracellular ATP-stimulated epithelial Na+ channel activity in renal epithelia. Am. J. Physiol Renal Physiol 292:F1734-F1740.
19. Sanchez, D., U. Anand, J. Gorelik, C. D. Benham, C. Bountra, M. Lab, D. Klenerman, R. Birch, P. Anand, and Y. Korchev. 2007. Localized and non-contact mechanical stimulation of dorsal root ganglion sensory neurons using scanning ion conductance microscopy. J. Neurosci. Methods 159:26-34.
20. Piper, J. D., R. W. Clarke, Y. E. Korchev, L. Ying, and D. Klenerman. 2006. A renewable nanosensor based on a glass nanopipette. J. Am. Chem. Soc. 128:16462-16463.
21. Klenerman, D. and Y. Korchev. 2006. Potential biomedical applications of the scanned nanopipette. Nanomed. 1:107-114.
22. Gorelik, J., L. Q. Yang, Y. Zhang, M. Lab, Y. Korchev, and S. E. Harding. 2006. A novel Z-groove index characterizing myocardial surface structure. Cardiovasc. Res. 72:422-429.
23. Gorelik, J., N. N. Ali, A. I. Shevchuk, M. Lab, C. Williamson, S. E. Harding, and Y. E. Korchev. 2006. Functional characterization of embryonic stem cell-derived cardiomyocytes using scanning ion conductance microscopy. Tissue Eng 12:657-664.
24. Gorelik, J., P. Patel, C. Ng'andwe, I. Vodyanoy, I. Diakonov, M. Lab, Y. Korchev, and C. Williamson. 2006. Genes encoding bile acid, phospholipid and anion transporters are expressed in a human fetal cardiomyocyte culture. BJOG. 113:552-558.
25. Shevchuk, A. I., G. I. Frolenkov, D. Sanchez, P. S. James, N. Freedman, M. J. Lab, R. Jones, D. Klenerman, and Y. E. Korchev. 2006. Imaging proteins in membranes of living cells by high-resolution scanning ion conductance microscopy. Angew. Chem. Int. Ed Engl. 45:2212-2216.
26. Rodolfa, K. T., A. Bruckbauer, D. Zhou, A. I. Schevchuk, Y. E. Korchev, and D. Klenerman. 2006. Nanoscale pipetting for controlled chemistry in small arrayed water droplets using a double-barrel pipet. Nano. Lett. 6:252-257.
27. Rodolfa, K. T., A. Bruckbauer, D. Zhou, Y. E. Korchev, and D. Klenerman. 2005. Two-component graded deposition of biomolecules with a double-barreled nanopipette. Angew. Chem. Int. Ed Engl. 44:6854-6859.
28. Gorelik, J., Y. Zhang, D. Sanchez, A. Shevchuk, G. Frolenkov, M. Lab, D. Klenerman, C. Edwards, and Y. Korchev. 2005. Aldosterone acts via an ATP autocrine/paracrine system: the Edelman ATP hypothesis revisited. Proc. Natl. Acad. Sci. U. S. A 102:15000-15005.
29. Ying, L., A. Bruckbauer, D. Zhou, J. Gorelik, A. Shevchuk, M. Lab, Y. Korchev, and D. Klenerman. 2005. The scanned nanopipette: a new tool for high resolution bioimaging and controlled deposition of biomolecules. Phys. Chem. Chem. Phys. 7:2859-2866.
30. Zhang, Y., J. Gorelik, D. Sanchez, A. Shevchuk, M. Lab, I. Vodyanoy, D. Klenerman, C. Edwards, and Y. Korchev. 2005. Scanning ion conductance microscopy reveals how a functional renal epithelial monolayer maintains its integrity. Kidney Int. 68:1071-1077.
31. Darszon, A., C. D. Wood, C. Beltran, D. Sanchez, E. Rodriguez, J. Gorelik, Y. E. Korchev, and T. Nishigaki. 2004. Measuring ion fluxes in sperm. Methods Cell Biol. 74:545-576.
32. Gu, Y., J. C. Kirkman-Brown, Y. Korchev, C. L. Barratt, and S. J. Publicover. 2004. Multi-state, 4-aminopyridine-sensitive ion channels in human spermatozoa. Dev. Biol. 274:308-317.
33. Gorelik, J., A. Shevchuk, S. M. de, M. Lab, Y. Korchev, and C. Williamson. 2004. Comparison of the arrhythmogenic effects of tauro- and glycoconjugates of cholic acid in an in vitro study of rat cardiomyocytes. BJOG. 111:867-870.
34. Bruckbauer, A., D. Zhou, D. J. Kang, Y. E. Korchev, C. Abell, and D. Klenerman. 2004. An addressable antibody nanoarray produced on a nanostructured surface. J. Am. Chem. Soc. 126:6508-6509.
35. Gorelik, J., Y. Zhang, A. I. Shevchuk, G. I. Frolenkov, D. Sanchez, M. J. Lab, I. Vodyanoy, C. R. Edwards, D. Klenerman, and Y. E. Korchev. 2004. The use of scanning ion conductance microscopy to image A6 cells. Mol. Cell Endocrinol. 217:101-108.
36. Ying, L., S. S. White, A. Bruckbauer, L. Meadows, Y. E. Korchev, and D. Klenerman. 2004. Frequency and voltage dependence of the dielectrophoretic trapping of short lengths of DNA and dCTP in a nanopipette. Biophys. J. 86:1018-1027.
37. Bruckbauer, A., D. Zhou, L. Ying, Y. E. Korchev, C. Abell, and D. Klenerman. 2003. Multicomponent submicron features of biomolecules created by voltage controlled deposition from a nanopipet. J. Am. Chem. Soc. 125:9834-9839.
38. Gorelik, J., I. Vodyanoy, A. I. Shevchuk, I. A. Diakonov, M. J. Lab, and Y. E. Korchev. 2003. Esmolol is antiarrhythmic in doxorubicin-induced arrhythmia in cultured cardiomyocytes - determination by novel rapid cardiomyocyte assay. FEBS Lett. 548:74-78.
39. Gorelik, J., A. I. Shevchuk, I. Diakonov, S. M. de, M. Lab, Y. Korchev, and C. Williamson. 2003. Dexamethasone and ursodeoxycholic acid protect against the arrhythmogenic effect of taurocholate in an in vitro study of rat cardiomyocytes. BJOG. 110:467-474.
40. Gorelik, J., A. I. Shevchuk, G. I. Frolenkov, I. A. Diakonov, M. J. Lab, C. J. Kros, G. P. Richardson, I. Vodyanoy, C. R. Edwards, D. Klenerman, and Y. E. Korchev. 2003. Dynamic assembly of surface structures in living cells. Proc. Natl. Acad. Sci. U. S. A 100:5819-5822.
41. Rothery, A. M., J. Gorelik, A. Bruckbauer, W. Yu, Y. E. Korchev, and D. Klenerman. 2003. A novel light source for SICM-SNOM of living cells. J. Microsc. 209:94-101.
42. Gorelik, J., Y. Gu, H. A. Spohr, A. I. Shevchuk, M. J. Lab, S. E. Harding, C. R. Edwards, M. Whitaker, G. W. Moss, D. C. Benton, D. Sanchez, A. Darszon, I. Vodyanoy, D. Klenerman, and Y. E. Korchev. 2002. Ion channels in small cells and subcellular structures can be studied with a smart patch-clamp system. Biophys. J. 83:3296-3303.
43. Gorelik, J., A. Shevchuk, M. Ramalho, M. Elliott, C. Lei, C. F. Higgins, M. J. Lab, D. Klenerman, N. Krauzewicz, and Y. Korchev. 2002. Scanning surface confocal microscopy for simultaneous topographical and fluorescence imaging: application to single virus-like particle entry into a cell. Proc. Natl. Acad. Sci. U. S. A 99:16018-16023.
44. Gorelik, J., S. E. Harding, A. I. Shevchuk, D. Koralage, M. Lab, S. M. de, Y. Korchev, and C. Williamson. 2002. Taurocholate induces changes in rat cardiomyocyte contraction and calcium dynamics. Clin. Sci. (Lond) 103:191-200.
45. Bruckbauer, A., L. Ying, A. M. Rothery, D. Zhou, A. I. Shevchuk, C. Abell, Y. E. Korchev, and D. Klenerman. 2002. Writing with DNA and protein using a nanopipet for controlled delivery. J. Am. Chem. Soc. 124:8810-8811.
46. Bruckbauer, A., L. Ying, A. M. Rothery, Y. E. Korchev, and D. Klenerman. 2002. Characterization of a novel light source for simultaneous optical and scanning ion conductance microscopy. Anal. Chem. 74:2612-2616.
47. Ying, L., A. Bruckbauer, A. M. Rothery, Y. E. Korchev, and D. Klenerman. 2002. Programmable delivery of DNA through a nanopipet. Anal. Chem. 74:1380-1385.
48. Gu, Y., J. Gorelik, H. A. Spohr, A. Shevchuk, M. J. Lab, S. E. Harding, I. Vodyanoy, D. Klenerman, and Y. E. Korchev. 2002. High-resolution scanning patch-clamp: new insights into cell function. FASEB J. 16:748-750.
49. Shevchuk, A. I., J. Gorelik, S. E. Harding, M. J. Lab, D. Klenerman, and Y. E. Korchev. 2001. Simultaneous measurement of Ca2+ and cellular dynamics: combined scanning ion conductance and optical microscopy to study contracting cardiac myocytes. Biophys. J. 81:1759-1764.
50. Siwy Z., Y. Gu, H. A. Spohr, D. Baur, A. Wolf-Reber, R. Spohr, P. Apel and Y.E. Korchev. 2002. Rectification and voltage gating of ion currents in a nanofabricated pore. Europhys. Lett., 60(3): 349-355
51. Apel YP, Korchev Y.E., Siwy Z, Spohr R, Yoshida M. (2001) Diode-like single-ion track membrane prepared by electro-stopping. Nuclear Instruments and Methods in Physics Research B. 184: 337-346
52. Williamson, C., J. Gorelik, B. M. Eaton, M. Lab, S. M. de, and Y. Korchev. 2001. The bile acid taurocholate impairs rat cardiomyocyte function: a proposed mechanism for intra-uterine fetal death in obstetric cholestasis. Clin. Sci. (Lond) 100:363-369.
53. Korchev, Y. E., Y. A. Negulyaev, C. R. Edwards, I. Vodyanoy, and M. J. Lab. 2000. Functional localization of single active ion channels on the surface of a living cell. Nat. Cell Biol. 2:616-619.
54. Korchev, Y. E., M. Raval, M. J. Lab, J. Gorelik, C. R. Edwards, T. Rayment, and D. Klenerman. 2000. Hybrid scanning ion conductance and scanning near-field optical microscopy for the study of living cells. Biophys. J. 78:2675-2679.
55. Korchev, Y. E., J. Gorelik, M. J. Lab, E. V. Sviderskaya, C. L. Johnston, C. R. Coombes, I. Vodyanoy, and C. R. Edwards. 2000. Cell volume measurement using scanning ion conductance microscopy. Biophys. J. 78:451-457.
56. Wolf, A., Siwy, Z., Korchev, Y.E., Reber, N., and Spohr R. 1999. Ion current fluctuations in artificial ion track pores – power spectrum and generalized entropy. Cell. Mol. Biol. Letters, 4: 553-565
57. Drake, L. J., G. C. Barker, Y. Korchev, M. Lab, H. Brooks, and D. A. Bundy. 1998. Molecular and functional characterization of a recombinant protein of Trichuris trichiura. Proc. Biol. Sci. 265:1559-1565.
58. Korchev, Y. E., C. L. Bashford, C. Pederzolli, C. A. Pasternak, P. J. Morgan, P. W. Andrew, and T. J. Mitchell. 1998. A conserved tryptophan in pneumolysin is a determinant of the characteristics of channels formed by pneumolysin in cells and planar lipid bilayers. Biochem. J. 329 ( Pt 3):571-577.
59. Korchev, Y. E., M. Milovanovic, C. L. Bashford, D. C. Bennett, E. V. Sviderskaya, I. Vodyanoy, and M. J. Lab. 1997. Specialized scanning ion-conductance microscope for imaging of living cells. J. Microsc. 188:17-23.
60. Korchev, Y. E., C. L. Bashford, M. Milovanovic, I. Vodyanoy, and M. J. Lab. 1997. Scanning ion conductance microscopy of living cells. Biophys. J. 73:653-658.

1. Simultaneous non-contact topography and electrochemical imaging by SECM/SICM featuring ion current feedback regulation (2010) Y Takahashi, A Shevchuk, P Novak, Y Murakami, H Shiku, Y Korchev, T Matsue JACS (accepted for publication)

2. V Nikolaev, A Moshkov, A Lyon, M Miragoli, P Novak, H Paur, M Lohse, Y Korchev, S Harding, J Gorelik (2010) Redistribution of ß2 adrenergic receptors leads to changes in camp compartmentation in heart failure. Science 327: 1653-1657.

3. J. Adler, A. I. Shevchuk, P. Novak, Y. E. Korchev, I. Parmryd. (2010) High Resolution Plasma Membrane Topography Imaging for Correct Interpretation of Single Particle Tracks. Nature Meth. 7: 170-171.

4. Sviderskaya, E.V., Easty, D.J., Lawrence, M.A., Sánchez, D., Negulyaev, Y.A., Patel, R.H., Anand, P., Korchev, Y.E. and Bennett, D.C. (2009) Functional neurons and melanocytes induced from immortal lines of postnatal neural crest-like stem cells. FASEB J 23:3179-3192

5. Alexander R. Lyon, Ken Macleod, Yanjun Zhang, Edwin Garcia, Gaelle Kikonda Kanda, Max Lab, Yuri Korchev, Sian E. Harding and Julia Gorelik. (2009) Loss of T-tubules and other changes to surface topography in ventricular myocytes from failing human and rat heart. Proc. Natl. Acad. Sci. U.S.A 106: 6854-6859

6. Banfic H, Visnjic D, Mise N, Balakrishnan S, Deplano S, Korchev YE, Domin J. (2009) Epidermal growth factor stimulates translocation of the class II phosphoinositide 3-kinase PI3K-C2beta to the nucleus. Biochem J. 422(1):53-60.

7. Pavel Novak, Chao Li, Andrew I. Shevchuk, Ruben Stepanyan, Matthew Caldwell, Simon Hughes, Trevor G. Smart, Julia Gorelik, Victor P. Ostanin, Max J. Lab, Guy W. J. Moss, Gregory I. Frolenkov, David Klenerman and Yuri E. Korchev. (2009) Nanoscale live cell imaging using hopping probe ion conductance microscopy. Nature Meth. 6: 279-281

8. U. Anand, W. Otto, D. Sanchez-Herrera, P. Facer, Y. Yiangou, Y. Korchev, R. Birch, C. Benham, C. Bountra, I. Chessell. (2008) Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neurons. Pain, 138 (3): 667-680

9. J Gorelik, N Ali, S Kadir, M Lab, P Stojkovic, L Armstrong, E Sviderskaya, Y Negulyaev, D Klenerman, D Bennett, M Lako, S Harding, M Stojkovic and Y Korchev. (2008) Non-invasive imaging of Stem Cells by Scanning ion conductance microscopy: future perspective. Tissue Eng., 14: 311-318

10. Joe D. Pipe, Chao Li, Chien-Jung Lo, Richard Berry, Yuri Korchev, Liming Ying and David Klenerman (2008) Characterization and Application of Controllable Local Chemical Changes Produced by Reagent Delivery from a Nanopipet J. Am. Chem. Soc., 130 (31): 10386–10393

11. Chao Li, Nicholas Johnson, Victor Ostanin, Andrew Shevchuk, Liming Ying, Yuri Korchev and David Klenerman. (2008) High resolution imaging using scanning ion conductance microscopy with improved distance feedback control. Prog Nat Sci., 18(6): 671-677

12. Kemp, S. J., A. J. Thorley, J. Gorelik, M. J. Seckl, M. J. O'Hare, A. Arcaro, Y. Korchev, P. Goldstraw, and T. D. Tetley. 2008. Immortalisation of Human Alveolar Epithelial Cells to Investigate Nanoparticle Uptake. Am. J. Respir. Cell Mol. Biol. 39(5):591-597

13. Sanchez, D., N. Johnson, C. Li, P. Novak, J. Rheinlaender, Y. Zhang, U. Anand, P. Anand, J. Gorelik, G. Frolenkov, C. Benham, M. Lab, V. Ostanin, T. E. Schaffer, D. Klenerman, and Y. Korchev. 2008. Non-contact measurement of the local mechanical properties of living cells using pressure applied via a pipette. Biophys. J. 95(6): 3017-3027

14. Shevchuk, A. I., P. Hobson, M. J. Lab, D. Klenerman, N. Krauzewicz, and Y. E. Korchev. 2008. Imaging single virus particles on the surface of cell membranes by high-resolution scanning surface confocal microscopy. Biophys. J. 94:4089-4094.

15. Shevchuk, A. I., P. Hobson, M. J. Lab, D. Klenerman, N. Krauzewicz, and Y. E. Korchev. 2008. Endocytic pathways: combined scanning ion conductance and surface confocal microscopy study. Pflugers Arch. 456:227-235.

16. Dutta, A. K., Y. E. Korchev, A. I. Shevchuk, S. Hayashi, Y. Okada, and R. Z. Sabirov. 2008. Spatial distribution of maxi-anion channel on cardiomyocytes detected by smart-patch technique. Biophys. J. 94:1646-1655.

17. Bruckbauer, A., P. James, D. Zhou, J. W. Yoon, D. Excell, Y. Korchev, R. Jones, and D. Klenerman. 2007. Nanopipette delivery of individual molecules to cellular compartments for single-molecule fluorescence tracking. Biophys. J. 93:3120-3131.

18. Zhang, Y., D. Sanchez, J. Gorelik, D. Klenerman, M. Lab, C. Edwards, and Y. Korchev. 2007. Basolateral P2X4-like receptors regulate the extracellular ATP-stimulated epithelial Na+ channel activity in renal epithelia. Am. J. Physiol Renal Physiol 292:F1734-F1740.

19. Sanchez, D., U. Anand, J. Gorelik, C. D. Benham, C. Bountra, M. Lab, D. Klenerman, R. Birch, P. Anand, and Y. Korchev. 2007. Localized and non-contact mechanical stimulation of dorsal root ganglion sensory neurons using scanning ion conductance microscopy. J. Neurosci. Methods 159:26-34.

20. Piper, J. D., R. W. Clarke, Y. E. Korchev, L. Ying, and D. Klenerman. 2006. A renewable nanosensor based on a glass nanopipette. J. Am. Chem. Soc. 128:16462-16463.

21. Klenerman, D. and Y. Korchev. 2006. Potential biomedical applications of the scanned nanopipette. Nanomed. 1:107-114.

22. Gorelik, J., L. Q. Yang, Y. Zhang, M. Lab, Y. Korchev, and S. E. Harding. 2006. A novel Z-groove index characterizing myocardial surface structure. Cardiovasc. Res. 72:422-429.

23. Gorelik, J., N. N. Ali, A. I. Shevchuk, M. Lab, C. Williamson, S. E. Harding, and Y. E. Korchev. 2006. Functional characterization of embryonic stem cell-derived cardiomyocytes using scanning ion conductance microscopy. Tissue Eng 12:657-664.

24. Gorelik, J., P. Patel, C. Ng'andwe, I. Vodyanoy, I. Diakonov, M. Lab, Y. Korchev, and C. Williamson. 2006. Genes encoding bile acid, phospholipid and anion transporters are expressed in a human fetal cardiomyocyte culture. BJOG. 113:552-558.

25. Shevchuk, A. I., G. I. Frolenkov, D. Sanchez, P. S. James, N. Freedman, M. J. Lab, R. Jones, D. Klenerman, and Y. E. Korchev. 2006. Imaging proteins in membranes of living cells by high-resolution scanning ion conductance microscopy. Angew. Chem. Int. Ed Engl. 45:2212-2216.

26. Rodolfa, K. T., A. Bruckbauer, D. Zhou, A. I. Schevchuk, Y. E. Korchev, and D. Klenerman. 2006. Nanoscale pipetting for controlled chemistry in small arrayed water droplets using a double-barrel pipet. Nano. Lett. 6:252-257.

27. Rodolfa, K. T., A. Bruckbauer, D. Zhou, Y. E. Korchev, and D. Klenerman. 2005. Two-component graded deposition of biomolecules with a double-barreled nanopipette. Angew. Chem. Int. Ed Engl. 44:6854-6859.

28. Gorelik, J., Y. Zhang, D. Sanchez, A. Shevchuk, G. Frolenkov, M. Lab, D. Klenerman, C. Edwards, and Y. Korchev. 2005. Aldosterone acts via an ATP autocrine/paracrine system: the Edelman ATP hypothesis revisited. Proc. Natl. Acad. Sci. U. S. A 102:15000-15005.

29. Ying, L., A. Bruckbauer, D. Zhou, J. Gorelik, A. Shevchuk, M. Lab, Y. Korchev, and D. Klenerman. 2005. The scanned nanopipette: a new tool for high resolution bioimaging and controlled deposition of biomolecules. Phys. Chem. Chem. Phys. 7:2859-2866.

30. Zhang, Y., J. Gorelik, D. Sanchez, A. Shevchuk, M. Lab, I. Vodyanoy, D. Klenerman, C. Edwards, and Y. Korchev. 2005. Scanning ion conductance microscopy reveals how a functional renal epithelial monolayer maintains its integrity. Kidney Int. 68:1071-1077.

31. Darszon, A., C. D. Wood, C. Beltran, D. Sanchez, E. Rodriguez, J. Gorelik, Y. E. Korchev, and T. Nishigaki. 2004. Measuring ion fluxes in sperm. Methods Cell Biol. 74:545-576.

32. Gu, Y., J. C. Kirkman-Brown, Y. Korchev, C. L. Barratt, and S. J. Publicover. 2004. Multi-state, 4-aminopyridine-sensitive ion channels in human spermatozoa. Dev. Biol. 274:308-317.

33. Gorelik, J., A. Shevchuk, S. M. de, M. Lab, Y. Korchev, and C. Williamson. 2004. Comparison of the arrhythmogenic effects of tauro- and glycoconjugates of cholic acid in an in vitro study of rat cardiomyocytes. BJOG. 111:867-870.

34. Bruckbauer, A., D. Zhou, D. J. Kang, Y. E. Korchev, C. Abell, and D. Klenerman. 2004. An addressable antibody nanoarray produced on a nanostructured surface. J. Am. Chem. Soc. 126:6508-6509.

35. Gorelik, J., Y. Zhang, A. I. Shevchuk, G. I. Frolenkov, D. Sanchez, M. J. Lab, I. Vodyanoy, C. R. Edwards, D. Klenerman, and Y. E. Korchev. 2004. The use of scanning ion conductance microscopy to image A6 cells. Mol. Cell Endocrinol. 217:101-108.

36. Ying, L., S. S. White, A. Bruckbauer, L. Meadows, Y. E. Korchev, and D. Klenerman. 2004. Frequency and voltage dependence of the dielectrophoretic trapping of short lengths of DNA and dCTP in a nanopipette. Biophys. J. 86:1018-1027.

37. Bruckbauer, A., D. Zhou, L. Ying, Y. E. Korchev, C. Abell, and D. Klenerman. 2003. Multicomponent submicron features of biomolecules created by voltage controlled deposition from a nanopipet. J. Am. Chem. Soc. 125:9834-9839.

38. Gorelik, J., I. Vodyanoy, A. I. Shevchuk, I. A. Diakonov, M. J. Lab, and Y. E. Korchev. 2003. Esmolol is antiarrhythmic in doxorubicin-induced arrhythmia in cultured cardiomyocytes - determination by novel rapid cardiomyocyte assay. FEBS Lett. 548:74-78.

39. Gorelik, J., A. I. Shevchuk, I. Diakonov, S. M. de, M. Lab, Y. Korchev, and C. Williamson. 2003. Dexamethasone and ursodeoxycholic acid protect against the arrhythmogenic effect of taurocholate in an in vitro study of rat cardiomyocytes. BJOG. 110:467-474.

40. Gorelik, J., A. I. Shevchuk, G. I. Frolenkov, I. A. Diakonov, M. J. Lab, C. J. Kros, G. P. Richardson, I. Vodyanoy, C. R. Edwards, D. Klenerman, and Y. E. Korchev. 2003. Dynamic assembly of surface structures in living cells. Proc. Natl. Acad. Sci. U. S. A 100:5819-5822.

41. Rothery, A. M., J. Gorelik, A. Bruckbauer, W. Yu, Y. E. Korchev, and D. Klenerman. 2003. A novel light source for SICM-SNOM of living cells. J. Microsc. 209:94-101.

42. Gorelik, J., Y. Gu, H. A. Spohr, A. I. Shevchuk, M. J. Lab, S. E. Harding, C. R. Edwards, M. Whitaker, G. W. Moss, D. C. Benton, D. Sanchez, A. Darszon, I. Vodyanoy, D. Klenerman, and Y. E. Korchev. 2002. Ion channels in small cells and subcellular structures can be studied with a smart patch-clamp system. Biophys. J. 83:3296-3303.

43. Gorelik, J., A. Shevchuk, M. Ramalho, M. Elliott, C. Lei, C. F. Higgins, M. J. Lab, D. Klenerman, N. Krauzewicz, and Y. Korchev. 2002. Scanning surface confocal microscopy for simultaneous topographical and fluorescence imaging: application to single virus-like particle entry into a cell. Proc. Natl. Acad. Sci. U. S. A 99:16018-16023.

44. Gorelik, J., S. E. Harding, A. I. Shevchuk, D. Koralage, M. Lab, S. M. de, Y. Korchev, and C. Williamson. 2002. Taurocholate induces changes in rat cardiomyocyte contraction and calcium dynamics. Clin. Sci. (Lond) 103:191-200.

45. Bruckbauer, A., L. Ying, A. M. Rothery, D. Zhou, A. I. Shevchuk, C. Abell, Y. E. Korchev, and D. Klenerman. 2002. Writing with DNA and protein using a nanopipet for controlled delivery. J. Am. Chem. Soc. 124:8810-8811.

46. Bruckbauer, A., L. Ying, A. M. Rothery, Y. E. Korchev, and D. Klenerman. 2002. Characterization of a novel light source for simultaneous optical and scanning ion conductance microscopy. Anal. Chem. 74:2612-2616.

47. Ying, L., A. Bruckbauer, A. M. Rothery, Y. E. Korchev, and D. Klenerman. 2002. Programmable delivery of DNA through a nanopipet. Anal. Chem. 74:1380-1385.

48. Gu, Y., J. Gorelik, H. A. Spohr, A. Shevchuk, M. J. Lab, S. E. Harding, I. Vodyanoy, D. Klenerman, and Y. E. Korchev. 2002. High-resolution scanning patch-clamp: new insights into cell function. FASEB J. 16:748-750.

49. Shevchuk, A. I., J. Gorelik, S. E. Harding, M. J. Lab, D. Klenerman, and Y. E. Korchev. 2001. Simultaneous measurement of Ca2+ and cellular dynamics: combined scanning ion conductance and optical microscopy to study contracting cardiac myocytes. Biophys. J. 81:1759-1764.

50. Siwy Z., Y. Gu, H. A. Spohr, D. Baur, A. Wolf-Reber, R. Spohr, P. Apel and Y.E. Korchev. 2002. Rectification and voltage gating of ion currents in a nanofabricated pore. Europhys. Lett., 60(3): 349-355

51. Apel YP, Korchev Y.E., Siwy Z, Spohr R, Yoshida M. (2001) Diode-like single-ion track membrane prepared by electro-stopping. Nuclear Instruments and Methods in Physics Research B. 184: 337-346

52. Williamson, C., J. Gorelik, B. M. Eaton, M. Lab, S. M. de, and Y. Korchev. 2001. The bile acid taurocholate impairs rat cardiomyocyte function: a proposed mechanism for intra-uterine fetal death in obstetric cholestasis. Clin. Sci. (Lond) 100:363-369.

53. Korchev, Y. E., Y. A. Negulyaev, C. R. Edwards, I. Vodyanoy, and M. J. Lab. 2000. Functional localization of single active ion channels on the surface of a living cell. Nat. Cell Biol. 2:616-619.

54. Korchev, Y. E., M. Raval, M. J. Lab, J. Gorelik, C. R. Edwards, T. Rayment, and D. Klenerman. 2000. Hybrid scanning ion conductance and scanning near-field optical microscopy for the study of living cells. Biophys. J. 78:2675-2679.

55. Korchev, Y. E., J. Gorelik, M. J. Lab, E. V. Sviderskaya, C. L. Johnston, C. R. Coombes, I. Vodyanoy, and C. R. Edwards. 2000. Cell volume measurement using scanning ion conductance microscopy. Biophys. J. 78:451-457.

56. Wolf, A., Siwy, Z., Korchev, Y.E., Reber, N., and Spohr R. 1999. Ion current fluctuations in artificial ion track pores – power spectrum and generalized entropy. Cell. Mol. Biol. Letters, 4: 553-565

57. Drake, L. J., G. C. Barker, Y. Korchev, M. Lab, H. Brooks, and D. A. Bundy. 1998. Molecular and functional characterization of a recombinant protein of Trichuris trichiura. Proc. Biol. Sci. 265:1559-1565.

58. Korchev, Y. E., C. L. Bashford, C. Pederzolli, C. A. Pasternak, P. J. Morgan, P. W. Andrew, and T. J. Mitchell. 1998. A conserved tryptophan in pneumolysin is a determinant of the characteristics of channels formed by pneumolysin in cells and planar lipid bilayers. Biochem. J. 329 ( Pt 3):571-577.

59. Korchev, Y. E., M. Milovanovic, C. L. Bashford, D. C. Bennett, E. V. Sviderskaya, I. Vodyanoy, and M. J. Lab. 1997. Specialized scanning ion-conductance microscope for imaging of living cells. J. Microsc. 188:17-23.

60. Korchev, Y. E., C. L. Bashford, M. Milovanovic, I. Vodyanoy, and M. J. Lab. 1997. Scanning ion conductance microscopy of living cells. Biophys. J. 73:653-658.

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