Critical Care, Pulmonary Vascular and Sleep Science
Head – Professor Tim Evans
Deputy - Professor Michael Polkey
Critical Care
The critical care team are primarily concerned with vascular disease as it affects the critically ill. Molecular and novel in vitro and in vivo models are used to facilitate the study of inflammatory pathways activated in pulmonary and systemic vascular disease, both congenital and acquired. Diseases of interest include primary and secondary pulmonary hypertension, pulmonary vascular malformation, sepsis, the systemic inflammatory response syndrome and the acute respiratory distress syndrome. Work continues to try and identify genes involved in disease process to enable the prediction of patients who will be at risk of acute respiratory failure following elective surgery.
Respiratory Muscles, Sleep and Ventilation
The overall aim of the Respiratory Muscles, Sleep and Ventilation group is to provide a unified approach to clinical, teaching and research activities, with the aim of translating physiological advances into clinical care. Our research can be divided into two board themes:
- Respiratory muscles in COPD, physiological approaches to the palliation of advanced COPD and lung regeneration.
- Cardiovascular and neurological consequences of sleep disturbances - particularly in vulnerable patients with pre existing heart disease and older people; include treatment with non-invasive ventilation, especially in the pediatric population.
