Professor Irene Roberts

The role of CD1d in normal and malignant haematopoiesis

(Professor Irene Roberts and Dr Anastasios Karadmitris)

We previously showed that invariant NKT cells, a potent subpopulation of CD1d-restricted regulatory T-cells, are required for effective haematopoiesis in vitro and in vivo and that CD1d is expressed on subsets of human haematopoietic stem/progenitor cells enriched for lymphoid progenitors (Kotsianidis et al, Blood 2006). We have recently found that in human B-cell malignancies, CD1d is also highly expressed, levels of expression correlate with disease progression and CD1d activates downstream signalling pathways. This project further investigates the role of CD1d-mediated signalling in normal and malignant B cell development, proliferation and survival using primary human cells and mouse models.

The clinical specialties relevant to: Haematology, oncology and paediatrics.

Further Information
http://www1.imperial.ac.uk/medicine/people/irene.roberts/

Contact Details
irene.roberts@imperial.ac.uk
Tel: +44 (0)20 8383 2163