Dr Anne Burke-Gaffney

Publications


Journals

  • Creagh-Brown BC; Burke-Gaffney A; Evans TW. (Mar 2011). sRAGE: a useful biomarker in acute lung injury?. Crit Care Med. 39:589-590. DOI.
  • Creagh-Brown BC; Quinlan GJ; Evans TW; Burke-Gaffney A. (Oct 2010). The RAGE axis in systemic inflammation, acute lung injury and myocardial dysfunction: an important therapeutic target?. Intensive Care Med. 36:1644-1656. DOI.
  • Leaver SK; MacCallum NS; Pingle V; Hacking MB; Quinlan GJ; Evans TW; Burke-Gaffney A. (Feb 2010). Increased plasma thioredoxin levels in patients with sepsis: positive association with macrophage migration inhibitory factor. Intensive Care Med. 36:336-341. DOI Open Access copy.
  • Burke-Gaffney A; Evans TW; Quinlan GJ. (Jul 2009). Thioredoxin in sepsis: Just another biomarker or a plausible therapeutic target?. CRIT CARE MED. 37:2304-2305. DOI.
  • Callister ME; Pinhu L; Catley MC; Westwell AD; Newton R; Leaver SK; Quinlan GJ; Evans TW; et alGriffiths MJ; Burke-Gaffney A. (Nov 2008). PMX464, a thiol-reactive quinol and putative thioredoxin inhibitor, inhibits NF-kappa B-dependent proinflammatory activation of alveolar epithelial cells. BRIT J PHARMACOL. 155:661-672. DOI.
  • Gao HM; Leaver SK; Burke-Gaffney A; Finney SJ. (Feb 2008). Severe sepsis and Toll-like receptors. SEMIN IMMUNOPATHOL. 30:29-40. DOI.
  • Finney SJ; Anning PB; Cao TV; Perretti M; Evans TW; Burke-Gaffney A. (28 Dec 2007). Butanol-extracted lipoteichoic acid induces in vivo leukocyte adhesion. BIOCHEM BIOPH RES CO. 364:831-837. DOI.
  • Leaver SK; Finney SJ; Burke-Gaffney A; Evans TW. (May 2007). Sepsis since the discovery of Toll-like receptors: disease concepts and therapeutic opportunities. Crit Care Med. 35:1404-1410. DOI.
  • Callister ME; Burke-Gaffney A; Quinlan GJ; Betts H; Nadel S; Evans TW. (Feb 2007). Persistently low plasma thioredoxin is associated with meningococcal septic shock in children. Intensive Care Med. 33:364-367. DOI.
  • Callister ME; Burke-Gaffney A; Quinlan GJ; Nicholson AG; Florio R; Nakamura H; Yodoi J; Evans TW. (Jun 2006). Extracellular thioredoxin levels are increased in patients with acute lung injury. Thorax. 61:521-527. DOI.
  • Burke-Gaffney A; Callister ME; Nakamura H. (Aug 2005). Thioredoxin: friend or foe in human disease?. Trends Pharmacol Sci. 26:398-404. DOI.
  • Burke-Gaffney A; Brooks AV; Bogle RG. (May 2002). Regulation of chemokine expression in atherosclerosis. Vascul Pharmacol. 38:283-292.
  • Burke-Gaffney A; Blease K; Hartnell A; Hellewell PG. (1 Feb 2002). TNF-alpha potentiates C5a-stimulated eosinophil adhesion to human bronchial epithelial cells: a role for alpha 5 beta 1 integrin. J Immunol. 168:1380-1388.
  • Stanford SJ; Pepper JR; Burke-Gaffney A; Mitchell JA. (Aug 2001). Cytokine-activated human vascular smooth muscle delays apoptosis of neutrophils: relevance of interactions between cyclo-oxygenase-2 and colony-stimulating factors. FASEB J. 15:1813-1815.
  • Stanford SJ; Pepper JR; Burke-Gaffney A; Mitchell JA. (Jun 2001). Cytokine-activated human vascular smooth muscle delays apoptosis of neutrophils: Relevance of interactions between cyclo-oxygenase-2 and colony stimulating factors. FASEB J. 15:1813-+. DOI.
  • Finney SJ; Anning PB; Burke-Gaffney A; Evans TW. (Dec 2000). Effects of lipoteichoic acid from gram positive bacteria on neutrophil adhesion: A comparison with lipopolysaccharide. THORAX. 55:A68-A68.
  • Brooks AVS; Blease K; Hellewell PG; Burke-Gaffney A. (Dec 2000). Production of chemokines during neutrophil-endothelial interactions. THORAX. 55:A1-A1.
  • Brooks AVS; Mitchell JA; Burke-Gaffney A. (Jan 2000). Involvement of p38 mitogen-activated protein kinase in interleukin-8 release from human neutrophils. BRIT J PHARMACOL. 129:U58-U58.
  • Jordan S; Evans TW; Burke-Gaffney A; Mitchell JA. (Jan 2000). Toxins associated with gram negative and gram positive bacteria stimulate: IL-8 release from human blood: Implications for ARDS. BRIT J PHARMACOL. 129:U58-U58.
  • Brooks AVS; Mitchell JA; Evans TW; Burke-Gaffney A. (Dec 1999). Stimulus-specific reduction of neutrophil interleukin-8 release in acute respiratory distress syndrome. THORAX. 54:A79-A79.
  • Blease K; Chen Y; Hellewell PG; Burke-Gaffney A. (1 Dec 1999). Lipoteichoic acid inhibits lipopolysaccharide-induced adhesion molecule expression and IL-8 release in human lung microvascular endothelial cells. J Immunol. 163:6139-6147.
  • Zhu J; Rogers AV; Burke-Gaffney A; Hellewell PG; Jeffery PK. (Jun 1999). Cytokine-induced airway epithelial ICAM-1 upregulation: quantification by high-resolution scanning and transmission electron microscopy. Eur Respir J. 13:1318-1328.
  • Burke-Gaffney A; Blease K; Hartnell A; Hellewell PG. (15 Mar 1999). An essential role for VLA-5-fibronectin interaction in TNF alpha priming of eosinophil adhesion. FASEB J. 13:A670-A670.
  • Burke-Gaffney A; Hellewell PG. (Dec 1998). Extracellular matrix proteins associated with human bronchial epithelial cells mediate eosinophil adhesion. BRIT J PHARMACOL. 125:U16-U16.
  • Blease K; Chen Y; Hellewell PG; Burke-Gaffney A. (Dec 1998). Interactions between lipoteichoic acid and lipopolysaccharide on human lung microvascular endothelial cell adhesion molecule expression and interleukin-8 release. BRIT J PHARMACOL. 125:U17-U17.
  • Burke-Gaffney A; Hellewell PG. (Sep 1998). A CD18/ICAM-1-dependent pathway mediates eosinophil adhesion to human bronchial epithelial cells. Am J Respir Cell Mol Biol. 19:408-418.
  • Bishop-Bailey D; Burke-Gaffney A; Hellewell PG; Pepper JR; Mitchell JA. (10 Aug 1998). Cyclo-oxygenase-2 regulates inducible ICAM-1 and VCAM-1 expression in human vascular smooth muscle cells. Biochem Biophys Res Commun. 249:44-47. DOI.
  • Blease K; Seybold J; Adcock IM; Hellewell PG; Burke-Gaffney A. (May 1998). Interleukin-4 and lipopolysaccharide synergize to induce vascular cell adhesion molecule-1 expression in human lung microvascular endothelial cells. Am J Respir Cell Mol Biol. 18:620-630.
  • Blease K; Burke-Gaffney A; Hellewell PG. (May 1998). Modulation of cell adhesion molecule expression and function on human lung microvascular endothelial cells by inhibition of phosphodiesterases 3 and 4. Br J Pharmacol. 124:229-237. DOI.
  • Blease K; Burke-Gaffney A; Hellewell PG. (20 Mar 1998). Lipoteichoic acid induces cell adhesion molecule expression and IL-8 release from human lung microvascular endothelial cells (HLMVEC). FASEB J. 12:A1005-A1005.
  • Burke-Gaffney A; Hellewell PG. (17 Mar 1998). TNF alpha priming of eosinophil adhesion: Critical role of beta(1)-integrins. FASEB J. 12:A576-A576.
  • Burke-Gaffney A; Macari DMT; Hellewell PG. (Dec 1997). Tumour necrosis factor-alpha primes eosinophil adhesion to human bronchial epithelial cells. BRIT J PHARMACOL. 122.
  • Burke-Gaffney A; Hellewell PG. (Apr 1997). Endogenous nitric oxide limits cytokine-induced damage of murine lung epithelial cells. Am J Physiol. 272:L707-L713.
  • Burke-Gaffney A; Hellewell PG. (Nov 1996). Tumour necrosis factor-alpha-induced ICAM-1 expression in human vascular endothelial and lung epithelial cells: modulation by tyrosine kinase inhibitors. Br J Pharmacol. 119:1149-1158.
  • Burke-Gaffney A; Hellewell PG. (3 Oct 1996). Eotaxin stimulates eosinophil adhesion to human lung microvascular endothelial cells. Biochem Biophys Res Commun. 227:35-40. DOI.
  • Burke-Gaffney A; Hellewell PG. (Feb 1996). Regulation of ICAM-1 by dexamethasone in a human vascular endothelial cell line EAhy926. Am J Physiol. 270:C552-C561.

Conferences

  • Leaver SK; Quinlan GJ; Evans TW; Burke-Gaffney A. THIOREDOXIN MODIFIES MIF RELEASE FROM HUMAN MONOCYTES FOLLOWING STIMULATION WITH LTA AND LPS. 65:A25-A26. (Dec 2010). DOI.
  • Kaneshamoorthy M; Creagh-Brown BC; Burke-Gaffney A. RAGE-MEDIATED CYTOKINE RELEASE FROM LEUKOCYTES: IMPLICATIONS FOR SYSTEMIC INFLAMMATION. 65:A23-A24. (Dec 2010). DOI.
  • Hacking MB; Leaver SK; MacCallum NS; Proudfoot A; Quinlan GJ; Burke-Gaffney A; Evans TW. EXTRACELLULAR THIOREDOXIN IS INCREASED IN PATIENTS WITH SEPSIS: A PROTECTIVE RESPONSE AGAINST RAISED PLASMA LEVELS OF MACROPHAGE MIGRATION INHIBITORY FACTOR?. 63:A70-A70. (Dec 2008).
  • Callister MEJ; Pinhu L; Finney SJ; Quinlan GJ; Catley M; Newton R; Adcock IM; Burke-Gaffney A; et alEvans TW. Inhibition of intracellular thioredoxin activity prevents inflammatory activation of an alveolar epithelial cell line through effects on the nuclear factor-kappa B signalling pathway. 58:1-1. (Dec 2003).
  • Finney SJ; Evans TW; Burke-Gaffney A. Divergent host response to cell wall components of Gram positive and negative bacteria. 17:A661-A661. (14 Mar 2003).
  • Callister MEJ; Burke-Gaffney A; Quinlan GJ; Nakamura H; Yodoi J; Evans TW. Elevation of thioredoxin concentrations in plasma and broncho-alveolar lavage fluid from patients with the acute respiratory distress syndrome. Winter Meeting of the British-Thoracic-Society. 57:U17-U17. (Dec 2002).
  • Brooks A; Blease K; Hellewell P; Evans T; Burke-Gaffney A. Neutrophil-endothelial contact and the regulation of chemokine production. Conference of the NATO Advanced-Study-Institute on Vascular Endothelium. 330:282-285. (2001).
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