Contact details
Dr Alejandro Carabe - Fernandez
Research Interests
Mathematical Modelling of radiation effects (in collaboration with Prof RG Dale and Prof B Jones) in the following fields:
RADIOBIOLOGY
- Relative Biological Effectiveness (RBE): determination of the clinically relevant values of RBE at different doses per fraction, treatment depths and Linear Energy Transfer (LET).
- High-Linear Energy Transfer (LET) Radiation effects: inclusion of oxygen enhancement ratio (OER) and investigation of optimum modelling techniques for correlation with experimental and clinical outcomes.
- Modification of Linear Quadratic model to include saturation of DNA repair enzymes (at low dose) and saturation of chromosomal targets (at high dose); Monte Carlo simulation of these effects.
- Study of the change of the Linear Quadratic model coefficients (α and β) with LET and the impact of these changes on the fractionation schemes used in non-conventional (high-LET) Radiotherpay.
- Expansion of non-exponential models based on second order repair kinetics to estimate the repair rate and the proportion of un-repairable damage associated to radiations of different quality.
- Calculation of equivalent radiation dose of non-radiation cancer treatments
- Changes in tissue fractionation sensitivity as a result of previous surgery/chemotherapy/age etc.
- Radiobiological treatment planning
RADIATION PHYSICS
- Monte Carlo simulation of radiation transport effects using BEAMnrc and GEANT4 with applications to conventional and non-conventional radiotherapy.
