Professor Alun D Hughes

Publications


Journals

  • Ghosh AK; Et al. (2012). Duration of diabetes is a significant independent predictor of elevated left ventricular mass. J Am Coll Cardiol;59:1727. 1727. DOI.
  • Ghosh AK; Et al. (2012). Mid-life anti-hypertensive treatment may not normalize left ventricular mass in spite of controlled blood pressure. J Am Coll Cardiol, 2012; 59:1722. 59:1722. DOI.
  • Hughes AD; Park C; March K; Coady E; Khir A; Chaturvedi N; Thom SA. (21 Apr 2012). A randomized placebo controlled double blind crossover study of pioglitazone on left ventricular diastolic function in type 2 diabetes. Int J Cardiol. DOI.
  • Liu D; Wood NB; Witt N; Hughes AD; Thom SA; Xu XY. (Jan 2012). Assessment of energy requirement for the retinal arterial network in normal and hypertensive subjects. J Biomech Eng. 134:014501. DOI.
  • Kyriacou A; Li Kam Wa ME; Pabari PA; Unsworth B; Baruah R; Willson K; Peters NS; Kanagaratnam P; et alHughes AD; Mayet J; Whinnett ZI; Francis DP. (26 Mar 2012). A systematic approach to designing reliable VV optimization methodology: Assessment of internal validity of echocardiographic, electrocardiographic and haemodynamic optimization of cardiac resynchronization therapy. Int J Cardiol. DOI.
  • Hughes AD; Park CM; Khir AW; March K; Coady E; Chaturvedi N; Thom SAM. (22 Nov 2011). Pioglitazone Treatment Improves Left Ventricular Function in Type 2 Diabetics. CIRCULATION. 124. Author weblink.
  • Barron AJ; Tapp RJ; Sharp A; Baksi AJ; Hughes AD; Mayet J. (22 Nov 2011). Long-Term Differential Effects of Amlodipine and Atenolol based Antihypertensive Therapy on Left Ventricular Structure and Function: An ASCOT Sub-Study. CIRCULATION. 124. Author weblink.
  • Baksi AJ; Davies JE; Hadjiloizou N; Baruah R; Unsworth B; Foale RA; Parker KH; Francis DP; et alMayet J; Hughes AD. (22 Nov 2011). Backward Propagation of Waves is Limited in the Human Arterial Tree. CIRCULATION. 124. Author weblink.
  • Baksi AJ; Davies JE; Hadjiloizou N; Baruah R; Unsworth B; Foale RA; Parker KH; Francis DP; et alMayet J; Hughes AD. (22 Nov 2011). Backward Propagation of Waves is Limited in the Human Arterial Tree. CIRCULATION. 124. Author weblink.
  • Dalsgaard NB; Ole F; Gerard C; Alun H; Ulfl S. (1 Jul 2006). Involvement of cyclic nucleotides and potassium channels in hypoxic vasodilatation in pig coronary arteries. ACTA PHARMACOLOGICA SINICA. 27:184-184.
  • Awahan R; Alun H; Vladimir M; Holger N; tian AC. (1 Jul 2006). Synchronized oscillations of [Ca(2+)]i in endothelial and smooth muscle cells in rat mesenteric small arteries exposed to cyclopiazonic acid (CPA). ACTA PHARMACOLOGICA SINICA. 27:154-154.
  • Park C; Bathula R; Shore AC; Tillin T; Strain WD; Chaturvedi N; Hughes AD. (Apr 2012). Impaired post-ischaemic microvascular hyperaemia in Indian Asians is unexplained by diabetes or other cardiovascular risk factors. Atherosclerosis. 221:503-507. DOI.
  • Puntmann VO; Nagel E; Hughes AD; Gebker R; Gaddum N; Chowienczyk P; Jahnke C; Mirelis J; et alSchnackenburg B; Paetsch I; Fleck E. (Mar 2012). Gender-specific differences in myocardial deformation and aortic stiffness at rest and dobutamine stress. Hypertension. 59:712-718. DOI.
  • Moraldo M; Bergamini C; Malaweera AS; Dhutia NM; Pabari PA; Willson K; Baruah R; Manisty C; et alDavies JE; Xu XY; Hughes AD; Francis DP. (2 Jan 2012). A novel fully automated method for mitral regurgitant orifice area quantification. Int J Cardiol. DOI.
  • Sen S; Escaned J; Malik IS; Mikhail GW; Foale RA; Mila R; Tarkin J; Petraco R; et alBroyd C; Jabbour R; Sethi A; Baker CS; Bellamy M; Al-Bustami M; Hackett D; Khan M; Lefroy D; Parker KH; Hughes AD; Francis DP; Di Mario C; Mayet J; Davies JE. (10 Apr 2012). Development and Validation of a New Adenosine-Independent Index of Stenosis Severity From Coronary Wave-Intensity Analysis: Results of the ADVISE (ADenosine Vasodilator Independent Stenosis Evaluation) Study. J Am Coll Cardiol. 59:1392-1402. DOI.
  • Manisty CH; Al-Hussaini A; Unsworth B; Baruah R; Pabari PA; Mayet J; Hughes AD; Whinnett ZI; et alFrancis DP. (1 Feb 2012). The acute effects of changes to AV delay on BP and stroke volume: potential implications for design of pacemaker optimization protocols. Circ Arrhythm Electrophysiol. 5:122-130. DOI.
  • Hughes AD. (Jan 2012). Genetic and early life influences on the human retinal microcirculation. Basic Clin Pharmacol Toxicol. 110:19-25. DOI.
  • Zhang X; Luckham PF; Hughes AD; Thom S; Xu XY. (15 Dec 2011). Development of lysolipid-based thermosensitive liposomes for delivery of high molecular weight proteins. Int J Pharm. 421:291-292. DOI.
  • Starke RD; Paschalaki KE; Ferraro F; Dryden NH; McKinnon TA; Sutton RE; Payne EM; Haskard DO; et alHughes AD; Cutler DF; Laffan MA; Randi AM. (Oct 2011). 39 Blood-derived endothelial progenitor cells from Von Willebrand's disease patients demonstrate that Von Willebrand factor regulates angiogenesis. Heart. 97:e7. DOI.
  • Khamis RY; Johns M; Thom S; Mayet J; McConnell E; Stanton A; Jeyapalan S; Annon S; et alWrigley S; Hughes A; Haskard DO. (1 Oct 2011). IGG ANTI-MALONEDIALDEHYDE-LDL ANTIBODIES ARE ASSOCIATED WITH LOW RISK OF CARDIOVASCULAR EVENTS IN A SUBSTUDY OF THE ANGLO-SCANDINAVIAN CARDIAC OUTCOMES TRIAL (ASCOT), AND ARE UNRELATED TO LDL, CRP LEVELS AND STATIN TREATMENT. HEART. 97:5-5. Author weblink DOI.
  • McCarthy N; Vangjeli C; Surendran P; Treumann A; Rooney C; Ho E; Sever P; Thom S; et alHughes A; Munroe P; Howard P; Johnson T; Caulfield MJ; Shields D; O'Brien E; Fitzgerald D; Stanton A. (1 Oct 2011). PPARGC1 beta is a genetic determinant of the cardiovascular risk factor, Thromboxane A2-an Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) sub-study. JOURNAL OF HUMAN HYPERTENSION. 25:625-625.
  • Ghosh AK; Hardy R; Kuh D; Hughes AD. (1 Oct 2011). The effect of life course systolic blood pressure on interventricular wall thickness. JOURNAL OF HUMAN HYPERTENSION. 25:629-629.
  • Unsworth B; Casula RP; Yadav H; Baruah R; Hughes AD; Mayet J; Francis DP. (12 Sep 2011). Contrasting effect of different cardiothoracic operations on echocardiographic right ventricular long axis velocities, and implications for interpretation of post-operative values. Int J Cardiol. DOI.
  • Davies JE; Sen S; Broyd C; Hadjiloizou N; Baksi J; Francis DP; Foale RA; Parker KH; et alHughes AD; Chukwuemeka A; Casula R; Malik IS; Mikhail GW; Mayet J. (4 Oct 2011). Arterial pulse wave dynamics after percutaneous aortic valve replacement: fall in coronary diastolic suction with increasing heart rate as a basis for angina symptoms in aortic stenosis. Circulation. 124:1565-1572. DOI.
  • Stankevicius E; Dalsgaard T; Kroigaard C; Beck L; Boedtkjer E; Misfeldt MW; Nielsen G; Schjorring O; et alHughes A; Simonsen U. (Dec 2011). Opening of small and intermediate calcium-activated potassium channels induces relaxation mainly mediated by nitric-oxide release in large arteries and endothelium-derived hyperpolarizing factor in small arteries from rat. J Pharmacol Exp Ther. 339:842-850. DOI.
  • Sever PS; Poulter NR; Chang CL; Hingorani A; Thom SA; Hughes AD; Welsh P; Sattar N; et alASCOT Investigators. (Feb 2012). Evaluation of C-reactive protein prior to and on-treatment as a predictor of benefit from atorvastatin: observations from the Anglo-Scandinavian Cardiac Outcomes Trial. Eur Heart J. 33:486-494. DOI.
  • Bathula R; Hughes AD; Panerai RB; Potter JF; McG Thom SA; Tillin T; Shore AC; Hale R; et alChambers J; Kooner J; Chaturvedi N. (Dec 2011). South Asians have adverse cerebrovascular haemodynamics, despite equivalent blood pressure, compared with Europeans. This is due to their greater hyperglycaemia. Int J Epidemiol. 40:1490-1498. DOI.
  • Wang J-J; Shrive NG; Parker KH; Hughes AD; Tyberg JV. (1 May 2011). Wave Propagation and Reflection in the Canine Aorta: Analysis Using a Reservoir-Wave Approach. CANADIAN JOURNAL OF CARDIOLOGY. 27. DOI.
  • Baruah R; Giannoni A; Willson K; Mebrate Y; Mayet J; Emdin M; Hughes AD; Manisty CH; et alFrancis DP. (26 Apr 2011). Real-Time Dynamic Carbon Dioxide Administration Reply. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 57:1789-1790. Author weblink DOI.
  • Kuh D; Pierce M; Adams J; Deanfield J; Ekelund U; Friberg P; Ghosh AK; Harwood N; et alHughes A; Macfarlane PW; Mishra G; Pellerin D; Wong A; Stephen AM; Richards M; Hardy R; NSHD scientific and data collection team. (Feb 2011). Cohort profile: updating the cohort profile for the MRC National Survey of Health and Development: a new clinic-based data collection for ageing research. Int J Epidemiol. 40:e1-e9. DOI.
  • Starmans-Kool MJ; Stanton AV; Xu YY; McG Thom SA; Parker KH; Hughes AD. (Feb 2011). High dietary salt intake increases carotid blood pressure and wave reflection in normotensive healthy young men. J Appl Physiol. 110:468-471. DOI.
  • Sofat R; Casas JP; Kumari M; Talmud PJ; Ireland H; Kivimaki M; Marmot M; Hughes AD; et alThom S; Ebrahim S; Whittaker JC; Smeeth L; Lawlor DA; Humphries SE; Hingorani AD. (1 Nov 2010). Genetic variation in complement factor H and risk of coronary heart disease: Eight new studies and a meta-analysis of around 48,000 individuals. ATHEROSCLEROSIS. 213:184-190. Author weblink DOI.
  • Pabari PA; Willson K; Stegemann B; van Geldorp IE; Kyriacou A; Moraldo M; Mayet J; Hughes AD; et alFrancis DP. (May 2011). When is an optimization not an optimization? Evaluation of clinical implications of information content (signal-to-noise ratio) in optimization of cardiac resynchronization therapy, and how to measure and maximize it. Heart Fail Rev. 16:277-290. DOI.
  • Giannoni A; Baruah R; Willson K; Mebrate Y; Mayet J; Emdin M; Hughes AD; Manisty CH; et alFrancis DP. (23 Nov 2010). Real-time dynamic carbon dioxide administration: a novel treatment strategy for stabilization of periodic breathing with potential application to central sleep apnea. J Am Coll Cardiol. 56:1832-1837. DOI.
  • Dhutia NM; Cole GD; Willson K; Rueckert D; Parker KH; Hughes AD; Francis DP. (22 Mar 2012). A new automated system to identify a consistent sampling position to make tissue Doppler and transmitral Doppler measurements of E, E' and E/E'. Int J Cardiol. 155:394-399. DOI.
  • Starke RD; Ferraro F; Paschalaki KE; Dryden NH; McKinnon TA; Sutton RE; Payne EM; Haskard DO; et alHughes AD; Cutler DF; Laffan MA; Randi AM. (20 Jan 2011). Endothelial von Willebrand factor regulates angiogenesis. Blood. 117:1071-1080. DOI.
  • Ariff BB; Glor FP; Crowe L; Xu XY; Vennart W; Firmin DN; Thom SM; Hughes AD. (Dec 2010). Carotid artery hemodynamics: observing patient-specific changes with amlodipine and lisinopril by using MR imaging computation fluid dynamics. Radiology. 257:662-669. DOI.
  • Whinnett ZI; Nott G; Davies JE; Willson K; Manisty CH; Kanagaratnam P; Peters NS; Davies DW; et alHughes AD; Mayet J; Francis DP. (Feb 2011). Maximizing efficiency of alternation algorithms for hemodynamic optimization of the AV delay of cardiac resynchronization therapy. Pacing Clin Electrophysiol. 34:217-225. DOI.
  • Hadjiloizou N; Davies J; Baksi J; Malik I; Shai S; Aguado-Sierra J; Foale R; Parker K; et alFrancis D; Hughes A; Mayet J. (1 Oct 2010). Different effects of left ventricular hypertrophy secondary to hypertension and aortic stenosis on wave generation in the coronary arteries. JOURNAL OF HUMAN HYPERTENSION. 24:703-703.
  • Witt NW; Chapman N; Thom SA; Stanton AV; Parker KH; Hughes AD. (Sep 2010). A novel measure to characterise optimality of diameter relationships at retinal vascular bifurcations. Artery Res. 4:75-80. DOI.
  • Ferenczi EA; Asaria P; Hughes AD; Chaturvedi N; Francis DP. (15 Aug 2010). Can a statin neutralize the cardiovascular risk of unhealthy dietary choices?. Am J Cardiol. 106:587-592. DOI.
  • Mostafa A; Mohamed MK; Saeed M; Hasan A; Fontanet A; Godsland I; Coady E; Esmat G; et alEl-Hoseiny M; Abdul-Hamid M; Hughes A; Chaturvedi N. (1 Aug 2010). Hepatitis C infection and clearance: impact on atherosclerosis and cardiometabolic risk factors. GUT. 59:1135-1140. Author weblink DOI.
  • Page CML; Khir AW; Hughes AD; Chung R; Henein MY. (9 Jul 2010). Normal asynchrony of left ventricular long and short axes: Their relationship with aortic hemodynamics. INTERNATIONAL JOURNAL OF CARDIOLOGY. 142:166-171. DOI.
  • Manisty C; Mayet J; Tapp RJ; Parker KH; Sever P; Poulter NR; Thom SA; Hughes AD; et alASCOT Investigators. (29 Jun 2010). Wave reflection predicts cardiovascular events in hypertensive individuals independent of blood pressure and other cardiovascular risk factors: an ASCOT (Anglo-Scandinavian Cardiac Outcome Trial) substudy. J Am Coll Cardiol. 56:24-30. DOI.
  • Bathula R; Hughes AD; Panerai R; Potter J; Thom SA; Francis DP; Shore AC; Kooner J; et alChaturvedi N. (Oct 2010). Indian Asians have poorer cardiovascular autonomic function than Europeans: this is due to greater hyperglycaemia and may contribute to their greater risk of heart disease. Diabetologia. 53:2120-2128. DOI.
  • Justesen BL; Mistry P; Chaturvedi N; Thom SA; Witt N; Kohler D; Hughes AD; Sjolie AK. (1 Jun 2010). Retinal arterioles have impaired reactivity to hyperoxia in type 1 diabetes. ACTA OPHTHALMOLOGICA. 88:453-457. DOI.
  • Baksi AJ; Treibel TA; Davies JE; Hadjiloizou N; Foale RA; Parker KH; Francis DP; Mayet J; et alHughes AD. (11 May 2010). Changes in the Central Arterial Pressure Pulse With Aging Reply. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 55:2183-2184. Author weblink DOI.
  • Tapp RJ; Sharp A; Stanton AV; O'Brien E; Chaturvedi N; Poulter NR; Sever PS; Thom SA; et alHughes AD; Mayet J; ASCOT Investigators. (27 Apr 2010). Differential effects of antihypertensive treatment on left ventricular diastolic function: an ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial) substudy. J Am Coll Cardiol. 55:1875-1881. DOI.
  • Strain WD; Chaturvedi N; Hughes A; Nihoyannopoulos P; Bulpitt CJ; Rajkumar C; Shore AC. (May 2010). Associations between cardiac target organ damage and microvascular dysfunction: the role of blood pressure. J Hypertens. 28:952-958. DOI.
  • Wimalasundera RC; Wijetunge S; Thom SM; Regan L; Hughes AD. (Mar 2010). Impaired recovery of intracellular calcium and force after activation in isolated myometrial and subcutaneous resistance arteries from women with preeclampsia. J Hypertens. 28:568-574. DOI.
  • Strain WD; Hughes AD; Mayet J; Wright AR; Kooner J; Chaturvedi N; Shore AC. (15 Jan 2010). Attenuation of microvascular function in those with cardiovascular disease is similar in patients of Indian Asian and European descent. BMC CARDIOVASCULAR DISORDERS. 10. Author weblink DOI.
  • Davies JE; Shanmuganathan M; Francis DP; Mayet J; Hackett DR; Hughes AD. (1 Jan 2010). Caution Using Brachial Systolic Pressure to Calibrate Radial Tonometric Pressure Waveforms: Lessons From Invasive Study. HYPERTENSION. 55:E4-E4. Author weblink DOI.
  • Witt NC; Chapman N; Thom S; Stanton AV; Parker KH; Hughes AD. (2010). A novel measure to characterise optimality of diameter relationships at retinal vascular bifurcations. Artery Research. 4:75-80. DOI.
  • Davies JE; Baksi J; Francis DP; Hadjiloizou N; Whinnett ZI; Manisty CH; Aguado-Sierra J; Foale RA; et alMalik IS; Tyberg JV; Parker KH; Mayet J; Hughes AD. (Feb 2010). The arterial reservoir pressure increases with aging and is the major determinant of the aortic augmentation index. Am J Physiol Heart Circ Physiol. 298:H580-H586. DOI.
  • Sharp AS; Tapp RJ; Thom SA; Francis DP; Hughes AD; Stanton AV; Zambanini A; O'Brien E; et alChaturvedi N; Lyons S; Byrd S; Poulter NR; Sever PS; Mayet J; ASCOT Investigators. (Mar 2010). Tissue Doppler E/E' ratio is a powerful predictor of primary cardiac events in a hypertensive population: an ASCOT substudy. Eur Heart J. 31:747-752. DOI.
  • Baksi AJ; Treibel TA; Davies JE; Hadjiloizou N; Foale RA; Parker KH; Francis DP; Mayet J; et alHughes AD. (24 Nov 2009). A meta-analysis of the mechanism of blood pressure change with aging. J Am Coll Cardiol. 54:2087-2092. DOI.
  • Liu D; Wood NB; Witt N; Hughes AD; Thom SA; Xu XY. (Nov 2009). Computational analysis of oxygen transport in the retinal arterial network. Curr Eye Res. 34:945-956. DOI.
  • Manisty C; Mayet J; Tapp RJ; Sever PS; Poulter N; McG Thom SA; Hughes AD; ASCOT Investigators. (Nov 2009). Atorvastatin treatment is associated with less augmentation of the carotid pressure waveform in hypertension: a substudy of the Anglo-Scandinavian Cardiac Outcome Trial (ASCOT). Hypertension. 54:1009-1013. DOI.
  • Kun A; Matchkov VV; Stankevicius E; Nardi A; Hughes AD; Kirkeby HJ; Demnitz J; Simonsen U. (Nov 2009). NS11021, a novel opener of large-conductance Ca(2+)-activated K(+) channels, enhances erectile responses in rats. Br J Pharmacol. 158:1465-1476. DOI.
  • Manisty CH; Zambanini A; Parker KH; Davies JE; Francis DP; Mayet J; Thom SAM; Hughes AD. (1 Oct 2009). Differences in the Magnitude of Wave Reflection Account for Differential Effects of Amlodipine- Versus Atenolol-Based Regimens on Central Blood Pressure An Anglo-Scandinavian Cardiac Outcome Trial Substudy. HYPERTENSION. 54:724-U73. Author weblink DOI.
  • Beulens JWJ; Patel A; Vingerling JR; Cruickshank JK; Hughes AD; Stanton A; Lu J; Thom SAM; et alGrobbee DE; Stolk RP. (1 Oct 2009). Effects of blood pressure lowering and intensive glucose control on the incidence and progression of retinopathy in patients with type 2 diabetes mellitus: a randomised controlled trial. DIABETOLOGIA. 52:2027-2036. Author weblink DOI.
  • Mahal S; Strain WD; Martinez-Perez ME; Thom SA; Chaturvedi N; Hughes AD. (Sep 2009). Comparison of the retinal microvasculature in European and African-Caribbean people with diabetes. Clin Sci (Lond). 117:229-236. DOI.
  • Mebrate Y; Willson K; Manisty CH; Baruah R; Mayet J; Hughes AD; Parker KH; Francis DP. (1 Sep 2009). Dynamic CO2 therapy in periodic breathing: a modeling study to determine optimal timing and dosage regimes. JOURNAL OF APPLIED PHYSIOLOGY. 107:696-706. Author weblink DOI.
  • Thom S; Stettler C; Stanton A; Witt N; Tapp R; Chaturvedi N; Allemann S; Mayet J; et alSever P; Poulter N; O'Brien E; Hughes A. (1 Aug 2009). Differential Effects of Antihypertensive Treatment on the Retinal Microcirculation An Anglo-Scandinavian Cardiac Outcomes Trial Substudy. HYPERTENSION. 54:405-408. Author weblink DOI.
  • Clunn GF; Sever PS; Hughes AD. (18 Feb 2010). Calcium channel regulation in vascular smooth muscle cells: synergistic effects of statins and calcium channel blockers. Int J Cardiol. 139:2-6. DOI.
  • Davies J; Parker KH; Francis DP; Hughes AD; Mayet J. (1 Jun 2009). What is the role of the aorta in directing coronary blood flow? Reply. HEART. 95:937-938. Author weblink.
  • Stettler C; Witt N; Tapp RJ; Thom S; Allemann S; Tillin T; Stanton A; O'Brien E; et alPoulter N; Gallimore JR; Hughes AD; Chaturvedi N. (1 Jun 2009). Serum Amyloid A, C-Reactive Protein, and Retinal Microvascular Changes in Hypertensive Diabetic and Nondiabetic Individuals An Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) substudy. DIABETES CARE. 32:1098-1100. Author weblink DOI.
  • Davies J; Parker KH; Francis DP; Hughes AD; Mayet J. (Jun 2009). [In Process Citation]. Heart. 95:937-938. Publisher weblink.
  • Torii R; Wood NB; Hadjiloizou N; Dowsey AW; Wright AR; Hughes AD; Davies J; Francis DP; et alMayet J; Yang G-Z; Thom SAM; Xu XY. (1 May 2009). Fluid-structure interaction analysis of a patient-specific right coronary artery with physiological velocity and pressure waveforms. COMMUNICATIONS IN NUMERICAL METHODS IN ENGINEERING. 25:565-580. Author weblink DOI.
  • Torii R; Wood NB; Hadjiloizou N; Dowsey AW; Wright AR; Hughes AD; Davies J; Francis DP; et alMayet J; Yang G-Z; Thom SAM; Xu XY. (1 Mar 2009). Stress phase angle depicts differences in coronary artery hemodynamics due to changes in flow and geometry after percutaneous coronary intervention. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 296:H765-H776. Author weblink DOI.
  • Diller G-P; Wasan BS; Thom SAM; Foale RA; Hughes AD; Francis DP; Mayet J. (1 Feb 2009). Evidence of Improved Regional Myocardial Function in Patients With Chronic Stable Angina and Apparent Normal Ventricular Function-A Tissue Doppler Study Before and After Percutaneous Coronary Intervention. JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY. 22:177-182. Author weblink DOI.
  • Sun N; Torii R; Wood NB; Hughes AD; Thom SA; Xu XY. (Feb 2009). Computational modeling of LDL and albumin transport in an in vivo CT image-based human right coronary artery. J Biomech Eng. 131:021003. DOI.
  • Hughes AD; Parker KH. (Feb 2009). Forward and backward waves in the arterial system: impedance or wave intensity analysis?. Med Biol Eng Comput. 47:207-210. DOI.
  • Tyberg JV; Davies JE; Wang Z; Whitelaw WA; Flewitt JA; Shrive NG; Francis DP; Hughes AD; et alParker KH; Wang J-J. (1 Feb 2009). Wave intensity analysis and the development of the reservoir-wave approach. MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING. 47:221-232. Author weblink DOI.
  • Williams B; Lacy PS; Cruickshank JK; Collier D; Hughes AD; Stanton A; Thom S; Thurston H. (6 Jan 2009). Impact of Statin Therapy on Central Aortic Pressures and Hemodynamics Principal Results of the Conduit Artery Function Evaluation-Lipid-Lowering Arm (CAFE-LLA) Study. CIRCULATION. 119:53-U98. Author weblink DOI.
  • Hughes AD; Wong TY; Witt N; Evans R; Thom SAM; Klein BE; Chaturvedi N; Klein R. (1 Jan 2009). Determinants of Retinal Microvascular Architecture in Normal Subjects. MICROCIRCULATION. 16:159-166. Author weblink DOI.
  • Sun N; Leung JH; Wood NB; Hughes AD; Thom SA; Cheshire NJ; Xu XY. (1 Jan 2009). Computational analysis of oxygen transport in a patient-specific model of abdominal aortic aneurysm with intraluminal thrombus. BRITISH JOURNAL OF RADIOLOGY. 82:S18-S23. DOI.
  • Torii R; Keegan J; Wood NB; Dowsey AW; Hughes AD; Yang G-Z; Firmin DN; Thom SAM; et alXu XY. (1 Jan 2009). The effect of dynamic vessel motion on haemodynamic parameters in the right coronary artery: a combined MR and CFD study. BRITISH JOURNAL OF RADIOLOGY. 82:S24-S32. DOI.
  • Tan FPP; Soloperto G; Bashford S; Wood NB; Thom S; Hughes A; Xu XY. (1 Dec 2008). Analysis of Flow Disturbance in a Stenosed Carotid Artery Bifurcation Using Two-Equation Transitional and Turbulence Models. JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME. 130. Author weblink DOI.
  • Davies JE; Parker KH; Francis DP; Hughes AD; Mayet J. (1 Dec 2008). What is the role of the aorta in directing coronary blood flow?. HEART. 94:1545-1547. Author weblink DOI.
  • Ieng SME; Davies JER; Francis DP; Parker KH; Mayet J; Hughes AD. (1 Oct 2008). Evidence of a 'common' reservoir pressure transmitted along the length of the aorta which is the predominate determinate of arterial pressure in humans. JOURNAL OF HUMAN HYPERTENSION. 22:734-734. Author weblink.
  • Davies JER; Whinnett ZI; Hadjiloizou N; Aguado-Sierra J; Parker KH; Francis DP; Hughes AD; Mayet J. (1 Oct 2008). Evidence of augmentation of systolic coronary blood flow by retrograde wave reflection travelling-back from the proximal aorta. JOURNAL OF HUMAN HYPERTENSION. 22:718-719. Author weblink.
  • Bathula R; Hughes AD; Thom S; Panerai R; Potter J; Francis DP; Shore A; Kooner J; et alChaturvedi N. (1 Oct 2008). Mechanisms for the greater impact of diabetes on stroke risk in Indian Asians compared to Europeans. JOURNAL OF HUMAN HYPERTENSION. 22:720-720. Author weblink.
  • Whinnett ZI; Davies JER; Nott G; Willson K; Manisty CH; Peters NS; Kanagaratnam P; Davies DW; et alHughes AD; Mayet J; Francis DP. (26 Sep 2008). Efficiency, reproducibility and agreement of five different hemodynamic measures for optimization of cardiac resynchronization therapy. INTERNATIONAL JOURNAL OF CARDIOLOGY. 129:216-226. Author weblink DOI.
  • Sharp A; Tapp R; Francis DP; McG Thom SA; Hughes AD; Stanton AV; Zambanini A; Chaturvedi N; et alByrd S; Poulter NR; Sever PS; Mayet J. (16 Sep 2008). Ethnicity and left ventricular diastolic function in hypertension an ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial) substudy. J Am Coll Cardiol. 52:1015-1021. DOI.
  • Tillin T; Hughes A; Godsland I; Forouhi N; McKeigue P; Chaturvedi N. (1 Sep 2008). Ethnic group differences in insulin resistance and dyslipidaemia be explained by differences in muscle mass and visceral fat?. DIABETOLOGIA. 51:S175-S176. Author weblink.
  • Beulens JW; Vingerling JR; Cruickshank JK; Hughes AD; Stanton A; Lu J; Patel A; Thom SAM; et alGrobbee DE; Stolk RP. (1 Sep 2008). Effects of blood pressure lowering on incidence and progression of retinopathy in patients with type 2 diabetes mellitus: A randomised controlled trial. DIABETOLOGIA. 51:S476-S476. Author weblink.
  • Tillin T; Evans RM; Witt NW; Sharp PS; McKeigue PM; Chaturvedi N; Hughes AD. (1 Sep 2008). Ethnic differences in retinal microvascular structure. DIABETOLOGIA. 51:1719-1722. Author weblink DOI.
  • Stettler C; Witt N; Tapp R; Stanton A; Thom S; Allemann S; Tillin T; Hughes AD; et alChaturvedi N. (1 Sep 2008). Retinal microvascular changes and risk of coronary heart disease in hypertensive diabetic and non-diabetic individuals: an ASCOT substudy. DIABETOLOGIA. 51:S16-S16. Author weblink.
  • Hadjiloizou N; Davies JE; Malik IS; Aguado-Sierra J; Willson K; Foale RA; Parker KH; Hughes AD; et alFrancis DP; Mayet J. (Sep 2008). Differences in cardiac microcirculatory wave patterns between the proximal left mainstem and proximal right coronary artery. Am J Physiol Heart Circ Physiol. 295:H1198-H1205. DOI.
  • Hughes AD; Stanton AV; Jabbar AS; Chapman N; Martinez-Perez ME; Thom SAM. (1 Aug 2008). Effect of antihypertensive treatment on retinal microvascular changes in hypertension. JOURNAL OF HYPERTENSION. 26:1703-1707. Author weblink.
  • Stankevicius E; Hughes A; Simonsen U. (1 Aug 2008). K(+) channels and release of nitric oxide. FUNDAMENTAL & CLINICAL PHARMACOLOGY. 22:9-9. Author weblink.
  • Manisty CH; Willson K; Davies JE; Whinnett ZI; Baruah R; Mebrate Y; Kanagaratnam P; Peters NS; et alHughes AD; Mayet J; Francis DP. (Jul 2008). Induction of oscillatory ventilation pattern using dynamic modulation of heart rate through a pacemaker. Am J Physiol Regul Integr Comp Physiol. 295:R219-R227. DOI.
  • Hughes AD; Davies JE; Francis D; Mayet J; Parker KH. (1 Jun 2008). Peripheral augmentation index and wave reflection in the radial artery. HYPERTENSION. 51:E45-E46. Author weblink DOI.
  • Stankevicius E; Kroigaard C; Rinno B; Boedtkjer E; Schjorring O; Litvin K; Hughes A; Simonsen U. (1 Jun 2008). A novel opener of small and intermediate calcium-activated K channels releases no and causes EDHF type vasodilatation in rat mesenteric arteries. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. 102:24-24. Author weblink.
  • Downie SP; Raynor SM; Firmin DN; Wood NB; Thom SA; Hughes AD; Parker KH; Wolfe JHN; et alXu XY. (1 May 2008). Effects of elastic compression stockings on wall shear stress in deep and superficial veins of the calf. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 294:H2112-H2120. Author weblink DOI.
  • Achour M; Jacq X; Ronde P; Alhosin M; Charlot C; Chataigneau T; Jeanblanc M; Macaluso M; et alGiordano A; Hughes AD; Schini-Kerth VB; Bronner C. (3 Apr 2008). The interaction of the SRA domain of ICBP90 with a novel domain of DNMT1 is involved in the regulation of VEGF gene expression. ONCOGENE. 27:2187-2197. Author weblink DOI.
  • Stolk RP; van Schooneveld MJ; Cruickshank JK; Hughes AD; Stanton A; Lu J; Patel A; Thom SAM; et alGrobbee DE; Vingerling JR. (1 Apr 2008). Retinal vascular lesions in patients of Caucasian and Asian origin with type 2 diabetes - Baseline results from the ADVANCE Retinal Measurements (AdRem) study. DIABETES CARE. 31:708-713. Author weblink DOI.
  • Tapp RJ; Witt N; Chaturvedi N; Evans R; Thom SA; Hughes AD; Ness A; Williams C. (1 Apr 2008). Low birth weight and retinal vascular caliber in young children - Reply. PEDIATRICS. 121:863-863. Author weblink DOI.
  • Stolk RP; van Schooneveld MJ; Cruickshank JK; Hughes AD; Stanton A; Lu J; Patel A; Thom SA; et alGrobbee DE; Vingerling JR; AdRem Project Team and ADVANCE Management Committee. (Apr 2008). Retinal vascular lesions in patients of Caucasian and Asian origin with type 2 diabetes: baseline results from the ADVANCE Retinal Measurements (AdRem) study. Diabetes Care. 31:708-713. DOI.
  • Bathula R; Francis DP; Hughes A; Chaturvedi N. (Apr 2008). Ethnic differences in heart rate: can these be explained by conventional cardiovascular risk factors?. Clin Auton Res. 18:90-95. DOI.
  • Whinnett ZI; Briscoe C; Davies JER; Willson K; Manisty CH; Davies W; Peters NS; Kanagaratnam P; et alHughes AD; Mayet J; Francis DP. (1 Mar 2008). The atrioventricular delay of cardiac resynchronization can be optimized hemodynamically during exercise and predicted from resting measurements. HEART RHYTHM. 5:378-386. Author weblink DOI.
  • Hughes AD; Parker K; Davies J. (2008). Waves in arteries: A review of wave intensity analysis in the systemic and coronary circulations. Artery Research. 2:51-59. DOI.
  • Aguado-Sierra J; Davies JE; Hadjiloizou N; Francis D; Mayet J; Hughes AD; Parker KH. (2008). Reservoir-wave separation and wave intensity analysis applied to carotid arteries: a hybrid 1D model to understand haemodynamics. Conf Proc IEEE Eng Med Biol Soc. 2008:1381-1384. DOI.
  • McGoldrick RB; Kingsbury M; Turner MA; Sheridan DJ; Hughes AD. (Dec 2007). Left ventricular hypertrophy induced by aortic banding impairs relaxation of isolated coronary arteries. Clin Sci (Lond). 113:473-478. DOI.
  • Rahman A; Hughes A; Matchkov V; Nilsson H; Aalkjaer C. (Dec 2007). Antiphase oscillations of endothelium and smooth muscle [Ca2+]i in vasomotion of rat mesenteric small arteries. Cell Calcium. 42:536-547. DOI.
  • Tillin T; Dhutia H; Chambers J; Malik I; Coady E; Mayet J; Wright AR; Kooner J; et alShore A; Thom S; Chaturvedi N; Hughes A. (13 Oct 2008). South Asian men have different patterns of coronary artery disease when compared with European men. INTERNATIONAL JOURNAL OF CARDIOLOGY. 129:406-413. Author weblink DOI.
  • Tapp RJ; Williams C; Witt N; Chaturvedi N; Evans R; Thom SA; Hughes AD; Ness A. (Nov 2007). Impact of size at birth on the microvasculature: the Avon Longitudinal Study of Parents and Children. Pediatrics. 120:e1225-e1228. DOI.
  • Dotsenko O; Chaturvedi N; Thom SAM; Wright AR; Mayet J; Shore A; Schalkwijk C; Hughes AD. (1 Oct 2007). Platelet and leukocyte activation, atherosclerosis and inflammation in European and South Asian men. JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 5:2036-2042. Author weblink DOI.
  • Malaweera ASN; Davies JE; Hadjiloizou N; Manisty C; Zambanini A; Aguado-Sierra J; Thom SA; Parker KH; et alFrancis DP; Mayet J; Hughes AD. (1 Oct 2007). Pulsatile arterial pressure is predominantly determined by the aortic reservoir, which can be determined non-invasively from peripheral measurement sites. JOURNAL OF HUMAN HYPERTENSION. 21:849-850. Author weblink.
  • Davies JE; Francis DP; Hadjiloizou N; Manisty CH; Aguado-Sierra J; Foale RA; Parker KH; Mayet J; et alHughes AD. (1 Oct 2007). Changes in arterial reservoir function, not wave reflection, account for the effect of ageing on pressure augmentation in the proximal aorta. JOURNAL OF HUMAN HYPERTENSION. 21:848-848. Author weblink.
  • Sun N; Wood NB; Hughes AD; Thom SAM; Xu XY. (1 Oct 2007). Influence of pulsatile flow on LDL transport in the arterial wall. ANNALS OF BIOMEDICAL ENGINEERING. 35:1782-1790. Author weblink DOI.
  • Wijetunge S; Hughes AD. (1 Sep 2007). Src family tyrosine kinases mediate contraction of rat isolated tail arteries in response to a hyposmotic stimulus. JOURNAL OF HYPERTENSION. 25:1871-1878. Author weblink DOI.
  • Augst AD; Ariff B; McG Thom SA; Xu XY; Hughes AD. (Aug 2007). Analysis of complex flow and the relationship between blood pressure, wall shear stress, and intima-media thickness in the human carotid artery. Am J Physiol Heart Circ Physiol. 293:H1031-H1037. DOI.
  • Curtis SL; Zambanini A; Mayet J; Thom SAM; Foale R; Parker KH; Hughes AD. (1 Jul 2007). Reduced systolic wave generation and increased peripheral wave reflection in chronic heart failure. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 293:H557-H562. Author weblink DOI.
  • Downie SP; Firmin DN; Wood NB; Thom SA; Hughes AD; Wolfe JNH; Xu XY. (1 Jul 2007). Role of MRI in investigating the effects of elastic compression stockings on the deformation of the superficial and deep veins in the lower leg. JOURNAL OF MAGNETIC RESONANCE IMAGING. 26:80-85. Author weblink DOI.
  • Hope SA; Hughes AD. (1 Jul 2007). Drug effects on the mechanical properties of large arteries in humans. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY. 34:688-693. Author weblink DOI.
  • Chaturvedi N; Coady E; Mayet J; Wright AR; Shore AC; Byrd S; Thom SAM; Kooner JS; et alSchalkwijk CG; Hughes AD. (1 Jul 2007). Indian Asian men have less peripheral arterial disease than European men for equivalent levels of coronary disease. ATHEROSCLEROSIS. 193:204-212. Author weblink DOI.
  • Hughes AD. (Jun 2007). The clinical assessment of retinal microvascular structure and therapeutic implications. Curr Treat Options Cardiovasc Med. 9:236-241.
  • Sun N; Wood NB; Hughes AD; Thom SA; Yun Xu X. (Jun 2007). Effects of transmural pressure and wall shear stress on LDL accumulation in the arterial wall: a numerical study using a multilayered model. Am J Physiol Heart Circ Physiol. 292:H3148-H3157. DOI.
  • Kox M; Wijetunge S; Pickkers P; Hughes AD. (Mar 2007). Inhibition of Src family tyrosine kinases prevents lipopolysaccharide-induced hyporeactivity in isolated rat tail arteries. Vascul Pharmacol. 46:195-200. DOI.
  • Tillin T; Evans R; Witt N; Chaturvedi N; Hughes A. (1 Mar 2007). Ethnic differences in retinal endothelial function and their relationships with glucose tolerance. DIABETIC MEDICINE. 24:47-47. Author weblink.
  • Martinez-Perez ME; Hughes AD; Thom SA; Bharath AA; Parker KH. (1 Feb 2007). Segmentation of blood vessels from red-free and fluorescein retinal images. MEDICAL IMAGE ANALYSIS. 11:47-61. Author weblink DOI.
  • Tillin T; Chambers J; Malik I; Coady E; Byrd S; Mayet J; Wright AR; Kooner J; et alShore A; Thom S; Chaturvedi N; Hughes A. (Feb 2007). Measurement of pulse wave velocity: site matters. J Hypertens. 25:383-389. DOI.
  • Stolk RP; Vingerling JR; Cruickshank JK; Hughes AD; Stanton A; Lu J; Patel A; Thom SAM; et alGrobbee DE. (1 Jan 2007). Rationale and design of the AdRem study: Evaluating the effects of blood pressure lowering and intensive glucose control on vascular retinal disorders in patients with type 2 diabetes mellitus. CONTEMPORARY CLINICAL TRIALS. 28:6-17. Author weblink DOI.
  • Davies JE; Hadjiloizou N; Leibovich D; Malaweera A; Alastruey-Arimon J; Whinnett ZI; Manisty CH; Francis DP; et alAguado-Sierra J; Foale RA; Malik IS; Parker KH; Mayet J; Hughes AD. (2007). Importance of the aortic reservoir in determining the shape of the arterial pressure waveform – The forgotten lessons of Frank. Artery Research. 1:40-45. DOI.
  • Torii R; Wood NB; Hughes AD; Thom SA; Aguado-Sierra J; Davies JE; Francis DP; Parker KH; et alXu XY. (2007). A computational study on the influence of catheter-delivered intravascular probes on blood flow in a coronary artery model. J Biomech. 40:2501-2509. DOI.
  • Hughes AD; Coady E; Raynor S; Mayet J; Wright AR; Shore AC; Kooner JS; Thom SA; et alChaturvedi N. (Jan 2007). Reduced endothelial progenitor cells in European and South Asian men with atherosclerosis. Eur J Clin Invest. 37:35-41. DOI.
  • Stankevicius E; Lopez-Valverde V; Rivera L; Hughes AD; Mulvany MJ; Simonsen U. (Nov 2006). Combination of Ca2+ -activated K+ channel blockers inhibits acetylcholine-evoked nitric oxide release in rat superior mesenteric artery. Br J Pharmacol. 149:560-572. DOI.
  • Whinnett ZI; Davies JE; Willson K; Manisty CH; Chow AW; Foale RA; Davies DW; Hughes AD; et alMayet J; Francis DP. (Nov 2006). Haemodynamic effects of changes in atrioventricular and interventricular delay in cardiac resynchronisation therapy show a consistent pattern: analysis of shape, magnitude and relative importance of atrioventricular and interventricular delay. Heart. 92:1628-1634. DOI.
  • Wood NB; Zhao SZ; Zambanini A; Jackson M; Gedroyc W; Thom SA; Hughes AD; Xu XY. (Nov 2006). Curvature and tortuosity of the superficial femoral artery: a possible risk factor for peripheral arterial disease. J Appl Physiol. 101:1412-1418. DOI.
  • Williams B; Lacy PS; Thurston H; Thom S; Hughes A; Cruickshank K; Stanton A; Collier D; et alO'Rourke M. (10 Oct 2006). Response to letters regarding article, "differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: Principal results of the Conduit Artery Function Evaluation (CAFE) Study". CIRCULATION. 114:E540-E541. Author weblink DOI.
  • Ariff B; Zambanini A; Vamadeva S; Barratt D; Xu Y; Sever P; Stanton A; Hughes A; et alThom S. (Sep 2006). Candesartan- and atenolol-based treatments induce different patterns of carotid artery and left ventricular remodeling in hypertension. Stroke. 37:2381-2384. DOI.
  • Rahman A; Hughes A; Matchkov V; Nilsson H; Aalkjaer C. (1 Jul 2006). Synchronized oscillations of [Ca2(+)](i) in endothelial and smooth muscle cells in rat mesenteric small arteries exposed to cyclopiazonic acid (CPA). ACTA PHARMACOLOGICA SINICA. 27:186-186. Author weblink.
  • Sun N; Wood NB; Hughes AD; Thom SA; Xu XY. (Jul 2006). Fluid-wall modelling of mass transfer in an axisymmetric stenosis: effects of shear-dependent transport properties. Ann Biomed Eng. 34:1119-1128. DOI.
  • Garcha RS; Hughes AD. (1 Jun 2006). CNP, but not ANP or BNP, relax human isolated subcutaneous resistance arteries by an action involving cyclic GMP and BKCa channels. JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM. 7:87-91. Author weblink DOI.
  • Witt N; Wong TY; Hughes AD; Chaturvedi N; Klein BE; Evans R; McNamara M; Thom SA; et alKlein R. (May 2006). Abnormalities of retinal microvascular structure and risk of mortality from ischemic heart disease and stroke. Hypertension. 47:975-981. DOI.
  • Whinnett ZI; Davies JE; Willson K; Chow AW; Foale RA; Davies DW; Hughes AD; Francis DP; et alMayet J. (May 2006). Determination of optimal atrioventricular delay for cardiac resynchronization therapy using acute non-invasive blood pressure. Europace. 8:358-366. DOI.
  • Hughes AD; Martinez-Perez E; Jabbar AS; Hassan A; Witt NW; Mistry PD; Chapman N; Stanton AV; et alBeevers G; Pedrinelli R; Parker KH; Thom SA. (May 2006). Quantification of topological changes in retinal vascular architecture in essential and malignant hypertension. J Hypertens. 24:889-894. DOI.
  • Davies JE; Whinnett ZI; Francis DP; Manisty CH; Aguado-Sierra J; Willson K; Foale RA; Malik IS; et alHughes AD; Parker KH; Mayet J. (11 Apr 2006). Evidence of a dominant backward-propagating "suction" wave responsible for diastolic coronary filling in humans, attenuated in left ventricular hypertrophy. Circulation. 113:1768-1778. DOI.
  • Williams B; Lacy PS; Thom SM; Cruickshank K; Stanton A; Collier D; Hughes AD; Thurston H. (7 Mar 2006). Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes - Principal results of the Conduit Artery Function Evaluation (CAFE) study. CIRCULATION. 113:1213-1225. Author weblink DOI.
  • Davies JE; Whinnett ZI; Francis DP; Willson K; Foale RA; Malik IS; Hughes AD; Parker KH; et alMayet J. (Feb 2006). Use of simultaneous pressure and velocity measurements to estimate arterial wave speed at a single site in humans. Am J Physiol Heart Circ Physiol. 290:H878-H885. DOI.
  • Ibrahim J; Berk BC; Hughes AD. (Jan 2006). Comparison of simultaneous measurements of blood pressure by tail-cuff and carotid arterial methods in conscious spontaneously hypertensive and Wistar-Kyoto rats. Clin Exp Hypertens. 28:57-72. DOI.
  • Aguado-Sierra J; Parker KH; Davies JE; Francis D; Hughes AD; Mayet J. (2006). Arterial pulse wave velocity in coronary arteries. Conf Proc IEEE Eng Med Biol Soc. 1:867-870. DOI.
  • Hughes AD. (2006). Retinal Microvascular Abnormalities, Cardiovascular Mortality Linked. Retina Today. 1:14-14.
  • Leung JH; Wright AR; Cheshire N; Crane J; Thom SA; Hughes AD; Xu Y. (19 May 2006). Fluid structure interaction of patient specific abdominal aortic aneurysms: a comparison with solid stress models. BIOMEDICAL ENGINEERING ONLINE. 5. Author weblink DOI.
  • Patel MK; Clunn GF; Lymn JS; Austin O; Hughes AD. (Jul 2005). Effect of serum withdrawal on the contribution of L-type calcium channels (CaV1.2) to intracellular Ca2+ responses and chemotaxis in cultured human vascular smooth muscle cells. Br J Pharmacol. 145:811-817. DOI.
  • Zambanini A; Cunningham SL; Parker KH; Khir AW; McG Thom SA; Hughes AD. (Jul 2005). Wave-energy patterns in carotid, brachial, and radial arteries: a noninvasive approach using wave-intensity analysis. Am J Physiol Heart Circ Physiol. 289:H270-H276. DOI.
  • Glor FP; Ariff B; Hughes AD; Verdonck PR; McG SA; Barratt DC; Xu XY. (1 Apr 2005). Operator dependence of 3-D ultrasound-based computational fluid dynamics for the carotid bifurcation. IEEE TRANSACTIONS ON MEDICAL IMAGING. 24:451-456. Author weblink DOI.
  • Crowe LA; Ariff B; Keegan J; Mohiaddin RH; Yang GZ; Hughes AD; McG Thom SA; Firmin DN. (Mar 2005). Comparison between three-dimensional volume-selective turbo spin-echo imaging and two-dimensional ultrasound for assessing carotid artery structure and function. J Magn Reson Imaging. 21:282-289. DOI.
  • Wijetunge S; Hughes AD. (Mar 2005). Mechanism of contraction of rat isolated tail arteries by hyposmotic solutions. J Vasc Res. 42:93-100. DOI.
  • Wimalasundera RC; Thom SA; Regan L; Hughes AD. (Feb 2005). Effects of vasoactive agents on intracellular calcium and force in myometrial and subcutaneous resistance arteries isolated from preeclamptic, pregnant, and nonpregnant woman. Am J Obstet Gynecol. 192:625-632. DOI.
  • Hughes A.. (2005). Thiazides and thiazide-like diuretics in hypertension: pharmacology and mode of action. Advances in Geriatric Care. 11:1-1.
  • Cunningham SL; Parker KH; Mayet J; Foale RA; Thom SAM; Hughes AD. (1 Dec 2004). Peripheral haemodynamics are altered in diastolic heart failure. HEART. 90:32-32. Author weblink.
  • Glor FP; Ariff B; Hughes AD; Crowe LA; Verdonck PR; Barratt DC; McG Thom SA; Firmin DN; et alXu XY. (Dec 2004). Image-based carotid flow reconstruction: a comparison between MRI and ultrasound. Physiol Meas. 25:1495-1509.
  • Hughes AD. (Dec 2004). How do thiazide and thiazide-like diuretics lower blood pressure?. J Renin Angiotensin Aldosterone Syst. 5:155-160. DOI.
  • Glor FP; Ariff B; Hughes AD; Verdonck PR; Barratt DC; Augst AD; Thom SAM; Xu XY. (1 Oct 2004). Influence of head position on carotid hemodynamics in young adults. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 287:H1670-H1681. Author weblink DOI.
  • Barratt DC; Ariff BB; Humphries KN; Thom SA; Hughes AD. (May 2004). Reconstruction and quantification of the carotid artery bifurcation from 3-D ultrasound images. IEEE Trans Med Imaging. 23:567-583.
  • Leung J; Wright A; Cheshire N; Thom SA; Hughes AD; Xu XY. (2004). Flow patterns and wall shear stresses in patient-specific models of the abdominal aortic aneurysm. Stud Health Technol Inform. 103:235-242.
  • Hughes A.. (2004). New Hypertension guidelines – what do they mean to current practice?. Essentials in Prescribing. 1-2.
  • Lymn JS; Gallagher KL; Clunn GF; Fexby SE; Patel MK; Hughes AD. (18 Dec 2003). PDGF stimulates DNA synthesis in human vascular smooth muscle cells via a novel wortmannin-insensitive phosphatidylinositol 3-kinase. FEBS Lett. 555:591-596.
  • Glor FP; Ariff B; Crowe LA; Hughes AD; Cheong PL; Thom SA; Verdonck PR; Firmin DN; et alBarratt DC; Xu XY. (Dec 2003). Carotid geometry reconstruction: a comparison between MRI and ultrasound. Med Phys. 30:3251-3261.
  • Mayet J; Hughes A. (Sep 2003). Cardiac and vascular pathophysiology in hypertension. Heart. 89:1104-1109.
  • Bicknell CD; Cowling MG; Clark MW; Delis KT; Jenkins MP; Hughes AD; Thom SA; Wolfe JH; et alCheshire NJ. (Jul 2003). Carotid angioplasty in a pulsatile flow model: factors affecting embolic potential. Eur J Vasc Endovasc Surg. 26:22-31.
  • Long Q; Ariff B; Zhao SZ; Thom SA; Hughes AD; Xu XY. (Apr 2003). Reproducibility study of 3D geometrical reconstruction of the human carotid bifurcation from magnetic resonance images. Magn Reson Med. 49:665-674. DOI.
  • Wimalasundera R; Fexby S; Regan L; Hughes AD. (1 Apr 2003). Effect of tumour necrosis factor-alpha and interleukin 1 beta on endothelium-dependent relaxation in rat mesenteric resistance arteries in vitro. BRITISH JOURNAL OF PHARMACOLOGY. 138:1285-1294. Author weblink DOI.
  • Augst AD; Barratt DC; Hughes AD; Glor FP; McG Thom SA; Xu XY. (Apr 2003). Accuracy and reproducibility of CFD predicted wall shear stress using 3D ultrasound images. J Biomech Eng. 125:218-222.
  • Glor FP; Long Q; Hughes AD; Augst AD; Ariff B; Thom SA; Verdonck PR; Xu XY. (Feb 2003). Reproducibility study of magnetic resonance image-based computational fluid dynamics prediction of carotid bifurcation flow. Ann Biomed Eng. 31:142-151.
  • Augst AD; Barratt DC; Hughes AD; Thom SA; Xu XY. (2003). Various issues relating to computational fluid dynamics simulations of carotid bifurcation flow based on models reconstructed from three-dimensional ultrasound images. Proc Inst Mech Eng H. 217:393-403.
  • Zambanini A; Thom SAM; Hughes AD; Parker KH. (1 Dec 2002). Central aortic pressure influences pulse wave velocity. HYPERTENSION. 40:E10-E10. Author weblink DOI.
  • Lymn JS; Patel MK; Clunn GF; Rao SJ; Gallagher KL; Hughes AD. (15 Nov 2002). Thrombospondin-1 differentially induces chemotaxis and DNA synthesis of human venous smooth muscle cells at the receptor-binding level. J Cell Sci. 115:4353-4360.
  • Wimalasundera RC; Larbalestier N; Smith JH; de Ruiter A; McG Thom SA; Hughes AD; Poulter N; Regan L; et alTaylor GP. (12 Oct 2002). Pre-eclampsia, antiretroviral therapy, and immune reconstitution. Lancet. 360:1152-1154.
  • Zhao SZ; Ariff B; Long Q; Hughes AD; Thom SA; Stanton AV; Xu XY. (Oct 2002). Inter-individual variations in wall shear stress and mechanical stress distributions at the carotid artery bifurcation of healthy humans. J Biomech. 35:1367-1377.
  • Martinez-Perez ME; Hughes AD; Stanton AV; Thom SA; Chapman N; Bharath AA; Parker KH. (Aug 2002). Retinal vascular tree morphology: a semi-automatic quantification. IEEE Trans Biomed Eng. 49:912-917. DOI.
  • Chapman N; Dell'omo G; Sartini MS; Witt N; Hughes A; Thom S; Pedrinelli R. (Aug 2002). Peripheral vascular disease is associated with abnormal arteriolar diameter relationships at bifurcations in the human retina. Clin Sci (Lond). 103:111-116.
  • Ariff B; Stanton A; Barratt D; Augst A; Glor F; Poulter N; Sever P; Xu Y; et alHughes A; Thom SA. (Jun 2002). Comparison of the effects of antihypertensive treatment with angiotensin II blockade and beta-blockade on carotid wall structure and haemodynamics: protocol and baseline demographics. J Renin Angiotensin Aldosterone Syst. 3:116-122. DOI.
  • Wimalasundera RC; McG Thom SA; Regan L; Hughes AD. (Jun 2002). Action of the endothelin receptor (ETA) antagonist BQ-123 on forearm blood flow in young normotensive subjects. Clin Sci (Lond). 102:661-666.
  • Mayet J; Stanton AV; Chapman N; Foale RA; Hughes AD; Thom SA. (Apr 2002). Is carotid artery intima-media thickening a reliable marker of early atherosclerosis?. J Cardiovasc Risk. 9:77-81.
  • Starmans-Kool MJ; Stanton AV; Zhao S; Xu XY; Thom SA; Hughes AD. (Mar 2002). Measurement of hemodynamics in human carotid artery using ultrasound and computational fluid dynamics. J Appl Physiol. 92:957-961. DOI.
  • Stanton AV; Mayet J; Chapman N; Foale RA; Hughes AD; Thom SA. (Mar 2002). Ethnic differences in carotid and left ventricular hypertrophy. J Hypertens. 20:539-543.
  • Fexby S; Wimalasundera R; Hughes AD. (1 Mar 2002). Comparison of histamine- and acetylcholine-induced relaxation of rat isolated mesenteric small arteries. BRITISH JOURNAL OF PHARMACOLOGY. 135. Author weblink.
  • Patel M; Mulloy B; Gallagher K; O'Brien L; Hughes AD. (1 Mar 2002). The antimitogenic action of the sulphated polysaccharide fucoidan differs from heparin in human vascular smooth muscle cells. BRITISH JOURNAL OF PHARMACOLOGY. 135. Author weblink.
  • Clunn GF; Patel MK; Sever PS; Hughes AD. (1 Mar 2002). Inhibition of rho-kinase impairs chemotaxis and mitogenesis and induces a change in morphology in human vascular smooth muscle cells. BRITISH JOURNAL OF PHARMACOLOGY. 135. Author weblink.
  • Harrington LS; Hughes AD; Lymn JS. (1 Mar 2002). Effects of organ culture on the contractility of rat mesenteric arteries. BRITISH JOURNAL OF PHARMACOLOGY. 135. Author weblink.
  • Wijetunge S; Dolphin AC; Hughes AD. (1 Feb 2002). Tyrosine kinases act directly on the alpha1 subunit to modulate Ca(v)2.2 calcium channels. Biochem Biophys Res Commun. 290:1246-1249. DOI.
  • King E; Xu XY; Hughes AD; Long Q; Thom SA; Parker KH. (2002). Quantification of the non-planarity of the human carotid bifurcation. Biorheology. 39:419-424.
  • Patel MK; Mulloy B; Gallagher KL; O'Brien L; Hughes AD. (Jan 2002). The antimitogenic action of the sulphated polysaccharide fucoidan differs from heparin in human vascular smooth muscle cells. Thromb Haemost. 87:149-154.
  • Zambanini A; Khir AW; Byrd SM; Parker KH; Thom SAM; Hughes AD. (2002). Wave intensity analysis: a novel non-invasive method for determining arterial wave transmission. Comp Cardiol. 29:717-720.
  • Stanton AV; Chapman JN; Mayet J; Sever PS; Poulter NR; Hughes AD; Thom SA. (Nov 2001). Effects of blood pressure lowering with amlodipine or lisinopril on vascular structure of the common carotid artery. Clin Sci (Lond). 101:455-464.
  • Wasan BS; Hughes A; Thom SA; Foale RA; Mayet J. (23 Oct 2001). Regional diastolic dysfunction in coronary artery disease. CIRCULATION. 104:636-636. Author weblink.
  • McGoldrick RB; Kingsbury MP; Turner MA; Sheridan DJ; Hughes AD. (1 Oct 2001). Effect of heart failure induced by aortic banding in guinea pigs on vasodilation of coronary and mesenteric small arteries in vitro. HYPERTENSION. 38:970-970. Author weblink.
  • Zambanini A; Byrd SM; Parker KH; Thom SAM; Hughes AD. (1 Oct 2001). Aortic reflections contribute minimally to the radial artery pressure waveform. HYPERTENSION. 38:976-976. Author weblink.
  • Barratt DC; Davies AH; Hughes AD; Thom SA; Humphries KN. (Oct 2001). Accuracy of an electromagnetic three-dimensional ultrasound system for carotid artery imaging. Ultrasound Med Biol. 27:1421-1425.
  • Augst AD; Barratt DC; Hughes AD; Thom SAM; Xu XY. (1 Oct 2001). CFD model of a human carotid artery bifurcation reconstructed from 3D ultrasound data. HYPERTENSION. 38:977-977. Author weblink.
  • Clunn GF; Patel MK; Sever PS; Hughes AD. (1 Oct 2001). Involvement of Rho-kinase in control of human vascular smooth muscle cell chemotaxis, mitogenesis and morphology. HYPERTENSION. 38:984-984. Author weblink.
  • Jabbar A; Martinez-Perez ME; Parker KH; Beevers G; Bharath A; Thom SMG; Hughes AD. (1 Oct 2001). Topology of retinal vasculature in essential and accelerated hypertension. HYPERTENSION. 38:977-977. Author weblink.
  • Zambanini A; Byrd SM; Parker KH; Thom SAM; Hughes AD. (1 Oct 2001). Expansion waves in muscular arteries: A sign of healthy endothelium?. HYPERTENSION. 38:970-970. Author weblink.
  • Wasan BS; Patel N; Hughes A; Thom SAM; Foale RA; Mayet J. (1 Oct 2001). Reductions in regional diastolic function in coronary artery disease. HYPERTENSION. 38:974-974. Author weblink.
  • Cunningham SL; Zambanini A; Parker KH; Mayet J; Foale RA; Thorn SAMCG; Hughes AD. (1 Sep 2001). Heart failure patients with hypertension have different patterns of wave reflection. EUROPEAN HEART JOURNAL. 22:532-532. Author weblink.
  • Garcha RS; Sever PS; Hughes AD. (Sep 2001). Mechanism of action of angiotensin II in human isolated subcutaneous resistance arteries. Br J Pharmacol. 134:188-196. DOI.
  • Unlu S; Clunn G; Schachter M; Demoliou-Mason C; Hughes AD. (Aug 2001). Action of an HMG CoA reductase inhibitor, lovastatin, on apoptosis of untransformed and ts-SV40 transformed human smooth muscle cells derived from saphenous vein. J Cardiovasc Pharmacol. 38:161-173.
  • Stanton A; Fitzgerald D; Hughes A; Mayet J; O'Brien E; Poulter NR; Sever PS; Shields D; et alThom S; Anglo-Scandinavian Cardiac Outcomes Trial. (Aug 2001). An intensive phenotyping study to enable the future examination of genetic influences on hypertension-associated cardiovascular disease. J Hum Hypertens. 15 Suppl 1:S13-S18.
  • Singer DRJ; Cappuccio FP; Carter ND; Hughes AD. (1 Aug 2001). New horizons in cardiovascular disease. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES. 11:285-286. Author weblink.
  • Hughes AD; Thom S. (Jul 2001). Wearing your heart in your sleeve?. Eur Heart J. 22:1071-1073. DOI.
  • Barratt DC; Davies AH; Hughes AD; Thom SA; Humphries KN. (Jul 2001). Optimisation and evaluation of an electromagnetic tracking device for high-accuracy three-dimensional ultrasound imaging of the carotid arteries. Ultrasound Med Biol. 27:957-968.
  • Sever PS; Hughes A. (Jun 2001). Angiotensin receptor antagonists and vaso-vagal attacks due to sensitisation of the Bezold-Jarisch reflex?. J Hum Hypertens. 15:437-438. DOI.
  • Chapman N; Witt N; Gao X; Bharath AA; Stanton AV; Thom SA; Hughes AD. (Jan 2001). Computer algorithms for the automated measurement of retinal arteriolar diameters. Br J Ophthalmol. 85:74-79.
  • Pickkers P; Hughes AD; Russel FG; Thien T; Smits P. (Jan 2001). In vivo evidence for K(Ca) channel opening properties of acetazolamide in the human vasculature. Br J Pharmacol. 132:443-450. DOI.
  • Clunn G; Hughes A; Schachter M. (16 Dec 2000). Endotoxin-lipoprotein hypothesis. LANCET. 356:2097-2098. Author weblink DOI.
  • Chapman N; Haimes G; Stanton AV; Thom SA; Hughes AD. (Dec 2000). Acute effects of oxygen and carbon dioxide on retinal vascular network geometry in hypertensive and normotensive subjects. Clin Sci (Lond). 99:483-488.
  • Ibrahim J; Hughes AD; Sever PS. (Nov 2000). Action of angiotensin II on DNA synthesis by human saphenous vein in organ culture. Hypertension. 36:917-921.
  • Ariff BB; Zambanini A; Mayet J; Hughes AD; Thom SM. (31 Oct 2000). Intima-medial area: A more robust method than intima media thickness for analysing non-cardiac gated common carotid images. CIRCULATION. 102:729-729. Author weblink.
  • Gao XW; Bharath A; Stanton A; Hughes A; Chapman N; Thom S. (Oct 2000). Quantification and characterisation of arteries in retinal images. Comput Methods Programs Biomed. 63:133-146.
  • Garcha RS; Sever PS; Hughes AD. (1 Oct 2000). Mechanisms of angiotensin II-induced contraction in human isolated subcutaneous resistance arteries. HYPERTENSION. 36:672-672. Author weblink.
  • Zhao SZ; Zambanini A; Long Q; Xu XY; Hughes AD; Thom SA. (1 Oct 2000). Difference in anatomical features of the femoral artery between male and female. HYPERTENSION. 36:666-666. Author weblink.
  • Xu XY; Zhao SZ; Ariff B; Long Q; Hughes AD; Thorn SA; Stanton AV. (1 Oct 2000). Shear stress and mechanical forces in the walls of carotid arteries. HYPERTENSION. 36:664-664. Author weblink.
  • Cunningham SL; Zambanini A; Mayet J; Foale RA; Parker KH; Thom SAM; Hughes AD. (1 Aug 2000). Wave intensity analysis: a novel non-invasive method for assessing haemodynamics in heart failure. EUROPEAN HEART JOURNAL. 21:406-406. Author weblink.
  • Zhao SZ; Xu XY; Hughes AD; Thom SA; Stanton AV; Ariff B; Long Q. (Aug 2000). Blood flow and vessel mechanics in a physiologically realistic model of a human carotid arterial bifurcation. J Biomech. 33:975-984.
  • Chapman JN; Haimes G; Stanton AV; Thom SA; Hughes AD. (1 Jun 2000). Acute effects of oxygen and carbon dioxide on retinal arteriolar network geometry: differences between hypertensives and normotensives. JOURNAL OF PHYSIOLOGY-LONDON. 525:20P-21P. Author weblink.
  • Hughes AD. (Jun 2000). AT(1)-signalling in vascular smooth muscle. J Renin Angiotensin Aldosterone Syst. 1:125-130. DOI.
  • Wijetunge S; Dolphin AC; Hughes AD. (1 Jun 2000). Effect of tyrosine kinase inhibitors on voltage operated calcium channels expressed in COS-7 cells. JOURNAL OF PHYSIOLOGY-LONDON. 525:70P-71P.
  • Hill PB; Dora KA; Hughes AD; Garland CJ. (1 Jun 2000). The involvement of intracellular Ca2+ in 5-HT1B/1D receptor-mediated contraction of the rabbit isolated renal artery. BRITISH JOURNAL OF PHARMACOLOGY. 130:835-842. Author weblink DOI.
  • Barratt DC; Ariff BB; Davies AH; Hughes AD; Thom SAM; Humphries KNN. (1 Jun 2000). A system for three-dimensional vascular ultrasound imaging. JOURNAL OF PHYSIOLOGY-LONDON. 525:4P-5P. Author weblink.
  • Singer DR; Cappuccio FP; Carter ND; Hughes AD. (1 Jun 2000). New themes in hypertension - Proceedings of the 10th Annual Symposium of the London Hypertension Society - Introduction. JOURNAL OF HUMAN HYPERTENSION. 14:359-359. Author weblink DOI.
  • Xu XY; Zhao SZ; Long Q; Ariff B; Hughes AD; Thom SA. (1 Jun 2000). 3D reconstruction of flow patterns and shear stress in human arteries. JOURNAL OF PHYSIOLOGY-LONDON. 525:4P-4P. Author weblink.
  • Hsieh JK; Kletsas D; Clunn G; Hughes AD; Schachter M; Demoliou-Mason C. (Apr 2000). p53, p21(WAF1/CIP1), and MDM2 involvement in the proliferation and apoptosis in an in vitro model of conditionally immortalized human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 20:973-981.
  • Wijetunge S; Lymn JS; Hughes AD. (Apr 2000). Effects of protein tyrosine kinase inhibitors on voltage-operated calcium channel currents in vascular smooth muscle cells and pp60(c-src) kinase activity. Br J Pharmacol. 129:1347-1354. DOI.
  • Long Q; Xu XY; Ariff B; Thom SA; Hughes AD; Stanton AV. (Mar 2000). Reconstruction of blood flow patterns in a human carotid bifurcation: a combined CFD and MRI study. J Magn Reson Imaging. 11:299-311.
  • Hsieh JK; Kletsas D; Clunn G; Hughes AD; Schachter M; Demoliou-Mason C. (Mar 2000). p53, p21(WAF1/CIP1), and MDM2 involvement in proliferation and apoptosis in an in vitro model of conditionally immortalized human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 20:636-644.
  • Lymn JS; Hughes AD. (Feb 2000). Phospholipase C Isoforms, Cytoskeletal Organization, and Vascular Smooth Muscle Differentiation. News Physiol Sci. 15:41-45.
  • Unlu S; Mason CD; Schachter M; Hughes AD. (Feb 2000). Perillyl alcohol, an inhibitor of geranylgeranyl transferase, induces apoptosis of immortalized human vascular smooth muscle cells in vitro. J Cardiovasc Pharmacol. 35:341-344.
  • Zambanini A; Cunningham SL; Ariff B; Parker KH; Thom SAMG; Hughes AD. (1 Jun 2000). Wave intensity analysis: A novel method for haemodynamic assessment in man. JOURNAL OF HYPERTENSION. 18:S61-S61. Author weblink.
  • Coombes JE; Hughes AD; Thom SA. (Dec 1999). Intravascular pressure-evoked changes in intracellular calcium [Ca2+]i and tone in rat mesenteric and rabbit cerebral arteries in vitro. J Hum Hypertens. 13:855-858.
  • Clunn GF; Wijetunge S; Hughes AD. (Dec 1999). Effect of hypercholesterolaemia on voltage-operated calcium channel currents in rabbit arterial smooth muscle cells. J Hum Hypertens. 13:849-853.
  • Austin O; Patel MK; Hughes AD. (1 Oct 1999). Lack of functional calcum channels in cultured human vascular smooth muscle cells is not due to absence of dihydropyridine binding sites. HYPERTENSION. 34:712-712. Author weblink.
  • Wijetunge S; Lymn J; Hughes AD. (1 Oct 1999). Endogenous c-src regulates L-type calcium channels in vascular smooth muscle cells (VSMC). HYPERTENSION. 34:712-712. Author weblink.
  • Starmans-Kool M; Stanton A; Zhao S; Xu Y; Hughes A; Thom S; Struijker H. (1 Oct 1999). Carotid haemodynamics and the effects of salt. HYPERTENSION. 34:706-706. Author weblink.
  • Wimalasundera R; Regan L; Thom S; Hughes A. (1 Oct 1999). Effects of TNF-alpha on relaxation of rat mesenteric vessels: a role in pre-eclampsia?. HYPERTENSION. 34:701-701. Author weblink.
  • Pickkers P; van Beek M; Hughes AD; Russel FGM; Thien T; Smits P. (1 Sep 1999). Presence and mechanism of direct vascular effects of amiloride in humans. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY. 34:388-393. Author weblink DOI.
  • Lymn JS; Rao SJ; Clunn GF; Gallagher KL; O'Neil C; Thompson NT; Hughes AD. (Sep 1999). Phosphatidylinositol 3-kinase and focal adhesion kinase are early signals in the growth factor-like responses to thrombospondin-1 seen in human vascular smooth muscle. Arterioscler Thromb Vasc Biol. 19:2133-2140.
  • Garcha RS; Sever PS; Hughes AD. (Aug 1999). Action of AT1 receptor antagonists on angiotensin II-induced tone in human isolated subcutaneous resistance arteries. Br J Pharmacol. 127:1876-1882. DOI.
  • Ibrahim J; Schachter M; Hughes AD; Sever PS. (Aug 1999). Low dose indapamide plus perindopril combination effects on cardiovascular structure and function in genetic hypertension. Clin Exp Pharmacol Physiol. 26:622-627.
  • Patel MK; Refson JS; Schachter M; Hughes AD. (May 1999). Characterization of [3H]-heparin binding in human vascular smooth muscle cells and its relationship to the inhibition of DNA synthesis. Br J Pharmacol. 127:361-368. DOI.
  • Zhao SZ; Xu XY; Collins MW; Stanton AV; Hughes AD; Thom SA. (May 1999). Flow in carotid bifurcations: effect of the superior thyroid artery. Med Eng Phys. 21:207-214.
  • Pickkers P; Garcha RS; Schachter M; Smits P; Hughes AD. (1 Apr 1999). Inhibition of carbonic anhydrase accounts for the direct vascular effects of hydrochlorothiazide. HYPERTENSION. 33:1043-1048. Author weblink.
  • Hughes AD; Wijetunge S. (Dec 1998). Role of tyrosine phosphorylation in excitation-contraction coupling in vascular smooth muscle. Acta Physiol Scand. 164:457-469.
  • Pickkers P; Hughes AD; Russel FGM; Thien T; Smits P. (1 Dec 1998). Thiazide-induced vasodilation in humans is mediated by potassium channel activation. HYPERTENSION. 32:1071-1076. Author weblink.
  • Unlu S; Mason CD; Hughes AD. (Nov 1998). Platelet-derived growth factor-BB induces apoptosis in cultured vascular smooth muscle cells derived from human saphenous vein. Biochem Soc Trans. 26:S325.
  • Unlu S; Mason CD; Hughes AD. (Nov 1998). Role of isoprenylation in the inhibitory action of lovastatin on proliferation of SV40 immortalized human saphenous vein smooth muscle cells. Biochem Soc Trans. 26:S324.
  • Unlu S; Mason CD; Schachter M; Hughes AD. (Nov 1998). Interactions between HMG-CoA reductase inhibition and UVB irradiation on proliferation and apoptosis in SM1 smooth muscle cells. Biochem Soc Trans. 26:S322.
  • Clunn GF; Lymn JS; Mac TT; Hughes AD. (1 Oct 1998). Inhibition of cultured human vascular smooth muscle cell chemotaxis by lovastatin. HYPERTENSION. 32:789-789. Author weblink.
  • Unlu S; Demoliou-Mason C; Hughes AD. (1 Oct 1998). Action of perillyl alcohol on growth and apoptosis in SV-40 transformed human vascular smooth muscle cells. HYPERTENSION. 32:789-789. Author weblink.
  • Patel MK; Refson JS; Schachter M; Hughes AD. (1 Oct 1998). Characterisation of [H-3]-heparin binding in human vascular smooth muscle cells. HYPERTENSION. 32:805-805. Author weblink.
  • Stanton AV; Chapman JN; Sever PS; Poulter NR; Hughes AD; Thom SA. (1 Oct 1998). Greater regression of early atherosclerosis by calcium channel blockade than by angiotensin converting enzyme inhibition. HYPERTENSION. 32:795-795. Author weblink.
  • Xie L; Clunn GF; Lymn JS; Hughes AD. (Aug 1998). Role of intracellular calcium ([Ca2+]i) and tyrosine phosphorylation in adhesion of cultured vascular smooth muscle cells to fibrinogen. Cardiovasc Res. 39:475-484.
  • Refson JS; Schachter M; Patel MK; Hughes AD; Munro E; Chan P; Wolfe JH; Sever PS. (30 Jun 1998). Vein graft stenosis and the heparin responsiveness of human vascular smooth muscle cells. Circulation. 97:2506-2510.
  • Thom SA; Gao X; Stanton AV; Chapman JN; Bharath A; Hughes AD. (1 Jun 1998). A computer system for automated retinal microvascular architecture quantification. JOURNAL OF HYPERTENSION. 16:S106-S106. Author weblink.
  • Hughes AD; Clunn GF; Lymn JS; Sampson LJ; Patel MK; Sever PS. (1 Jun 1998). Differentiation state affects the ability of Ca2+ channel antagonists to inhibit migration in human vascular smooth muscle cells. JOURNAL OF HYPERTENSION. 16:S16-S16. Author weblink.
  • Stanton AV; Chapman JN; Sever PS; Poulter NR; Hughes AD; Thom SA. (1 Jun 1998). Greater regression of early atherosclerosis by calcium channel blockade than by angiotensin converting enzyme inhibition. JOURNAL OF HYPERTENSION. 16:S25-S25. Author weblink.
  • Garcha RS; Sever PS; Hughes AD. (1 Jun 1998). Angiotensin II contracts human resistance arteries via tyrosine kinase activation and calcium channel opening. JOURNAL OF HYPERTENSION. 16:S3-S3. Author weblink.
  • Hodson EAM; Ashley CC; Hughes AD; Lymn JS. (27 May 1998). Regulation of phospholipase C-delta by GTP-binding proteins-rhoA as an inhibitory modulator. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. 1403:97-101. DOI.
  • Hughes AD. (May 1998). Molecular and cellular mechanisms of action of angiotensin II (AT1) receptors in vascular smooth muscle. J Hum Hypertens. 12:275-281.
  • Wijetunge S; Lymn JS; Hughes AD. (May 1998). Effect of inhibition of tyrosine phosphatases on voltage-operated calcium channel currents in rabbit isolated ear artery cells. Br J Pharmacol. 124:307-316. DOI.
  • Garcha RS; Sever PS; Hughes AD. (1 Jan 1998). Role of Ca2+ channels, MAP/ERK kinase (MEK) in angiotensin II-induced contraction in human isolated resistance arteries. JOURNAL OF VASCULAR RESEARCH. 35:18-18. Author weblink.
  • Wijetunge S; Hughes AD. (1 Jan 1998). Tyrosine phosphatases regulate voltage-operated calcium channels in smooth muscle cells isolated from rabbit ear artery. JOURNAL OF VASCULAR RESEARCH. 35:12-12. Author weblink.
  • Hughes AD; Garcha RS; Sever PS. (1 Jan 1998). Application of a two state model to the action of AT(1) antagonists in human resistance arteries. JOURNAL OF VASCULAR RESEARCH. 35:20-20. Author weblink.
  • Unlu S; Demoliou-Mason C; Schachter M; Hughes AD. (1 Dec 1997). Action of lovastatin on cell death in cultured SV-40 transformed human vascular smooth muscle cells. BRITISH JOURNAL OF PHARMACOLOGY. 122:U106-U106. Author weblink.
  • Chapman N; Mohamudally A; Cerutti A; Stanton A; Sayer AA; Cooper C; Barker D; Rauf A; et alEvans J; Wormald R; Sever P; Hughes A; Thom S. (Dec 1997). Retinal vascular network architecture in low-birth-weight men. J Hypertens. 15:1449-1453.
  • Clunn GF; Refson JS; Lymn JS; Hughes AD. (Nov 1997). Platelet-derived growth factor beta-receptors can both promote and inhibit chemotaxis in human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 17:2622-2629.
  • Unlu S; Mason CD; Hughes AD. (1 Oct 1997). Action of a statin on apoptosis in human vascular smooth muscle cells. HYPERTENSION. 30:70-70. Author weblink.
  • Patel MK; Lymn JS; Clunn GF; Hughes AD. (Oct 1997). Thrombospondin-1 is a potent mitogen and chemoattractant for human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 17:2107-2114.
  • Ruytenbeek K; Hughes AD. (1 Oct 1997). Action of hydrochlorothiazide on guinea pig isolated pressurized mesenteric arteries. HYPERTENSION. 30:115-115. Author weblink.
  • Pickkers P; Dormans TPJ; Russel FGM; Hughes AD; Thien T; Schaper N; Smits P. (16 Sep 1997). Direct vascular effects of furosemide in humans. CIRCULATION. 96:1847-1852. Author weblink.
  • Garcha RS; Hughes AD. (Sep 1997). Action of ryanodine on neurogenic responses in rat isolated mesenteric small arteries. Br J Pharmacol. 122:142-148. DOI.
  • Sawhney N; Patel MK; Schachter M; Hughes AD. (Sep 1997). Inhibition of proliferation by heparin and expression of p53 in cultured human vascular smooth muscle cells. J Hum Hypertens. 11:611-614.
  • Clunn GF; Lymn JS; Schachter M; Hughes AD. (Aug 1997). Differential effects of lovastatin on mitogen induced calcium influx in human cultured vascular smooth muscle cells. Br J Pharmacol. 121:1789-1795. DOI.
  • Wijetunge S; Hughes AD. (1 Mar 1997). An activator of c-Src tyrosine kinase (pY)EEI peptide increases voltage-operated calcium channel currents in vascular smooth muscle cells isolated from rabbit ear artery. BRITISH JOURNAL OF PHARMACOLOGY. 120:P83-P83. Author weblink.
  • Wijetunge S; Hughes AD. (9 Dec 1996). Activation of endogenous c-Src or a related tyrosine kinase by intracellular (pY)EEI peptide increases voltage-operated calcium channel currents in rabbit ear artery cells. FEBS Lett. 399:63-66.
  • Stanton AV; Mayet J; Hughes AD; Chapman NJ; Sever PS; Thom SA. (1 Oct 1996). Carotid and femoral artery intima-media thickness is similar in black and white hypertensive patients. HYPERTENSION. 28:703-703. Author weblink.
  • Schachter M; Sawhney N; Refson JS; Hughes AD; Sever PS. (1 Oct 1996). Thrombospondin and growth regulation in human vascular smooth muscle cells. HYPERTENSION. 28:704-704.
  • Chapman N; Mohamudally A; Stanton A; Sever P; Sayer AA; Cooper C; Barker D; Wormald R; et alEvans J; Rauf A; Hughes A; Thom S. (1 Oct 1996). Abnormal microvascular network geometry - The link between low birth weight and increased cardiovascular risk?. HYPERTENSION. 28:703-703. Author weblink.
  • Thom SA; Stanton AV; King LA; Sever PS; Hughes AD. (1 Oct 1996). Arteriolar length-diameter ratio; A geometric parameter of the retinal vasculature diagnostic of hypertension. HYPERTENSION. 28:703-703. Author weblink.
  • Hughes AD; Clunn GF; Refson J; Demoliou-Mason C. (Oct 1996). Platelet-derived growth factor (PDGF): actions and mechanisms in vascular smooth muscle. Gen Pharmacol. 27:1079-1089.
  • Xie LD; Clunn GF; Hughes AD. (1 Oct 1996). Intracellular signals involved in the attachment of vascular smooth muscle cells to fibrinogen. HYPERTENSION. 28:687-687. Author weblink.
  • Ibrahim J; Hughes AD; Sever PS. (1 Oct 1996). Non-AT1/AT2 receptor mediated growth by angiotensin II in human saphenous vein in culture. HYPERTENSION. 28:701-701. Author weblink.
  • Patel MK; Clunn GF; Lymn JS; Hughes AD. (Aug 1996). Thrombospondin-1 induces DNA synthesis and migration in human vascular smooth muscle cells. Biochem Soc Trans. 24:446S.
  • Ibrahim J; Hughes AD; Schachter M; Sever PS. (Aug 1996). Depletion of resistance vessel polyamines attenuates angiotensin II induced blood pressure rise in rats. Clin Exp Hypertens. 18:811-830.
  • Pickkers P; Schachter M; Hughes AD; Feher MD; Sever PS. (Jul 1996). Thiazide-induced hyperglycaemia: a role for calcium-activated potassium channels?. Diabetologia. 39:861-864.
  • Pickkers P; Garcha R; Schachter M; Hughes AD. (1 Jul 1996). Action of thiazides and inhibitors of carbonic anhydrase on tone of guinea-pig isolated small mesenteric arteries. BRITISH JOURNAL OF PHARMACOLOGY. 118:P16-P16. Author weblink.
  • Hughes AD. (Jun 1996). The role of isoprenoids in vascular smooth muscle: potential benefits of statins unrelated to cholesterol lowering. J Hum Hypertens. 10:387-390.
  • King LA; Stanton AV; Sever PS; Thom SA; Hughes AD. (Jun 1996). Arteriolar length-diameter (L:D) ratio: a geometric parameter of the retinal vasculature diagnostic of hypertension. J Hum Hypertens. 10:417-418.
  • Ibrahim J; Hughes AD; Schachter M; Sever PS. (May 1996). Enhanced tissue polyamine content in the spontaneously hypertensive rat. Clin Exp Pharmacol Physiol. 23:410-414.
  • Patel MK; Betteridge LJ; Hughes AD; Clunn GF; Schachter M; Shaw RJ; Sever PS. (Mar 1996). Effect of angiotension II on the expression of the early growth response gene c-fos and DNA synthesis in human vascular smooth muscle cells. J Hypertens. 14:341-347.
  • Hughes AD; Parkinson NA; Wijetunge S. (Jan 1996). alpha2-Adrenoceptor activation increases calcium channel currents in single vascular smooth muscle cells isolated from human omental resistance arteries. J Vasc Res. 33:25-31.
  • Wijetunge S; Hughes AD. (26 Dec 1995). pp60c-src increases voltage-operated calcium channel currents in vascular smooth muscle cells. Biochem Biophys Res Commun. 217:1039-1044. DOI.
  • Stanton AV; Wasan B; Cerutti A; Ford S; Marsh R; Sever PP; Thom SA; Hughes AD. (Dec 1995). Vascular network changes in the retina with age and hypertension. J Hypertens. 13:1724-1728.
  • Clunn GF; Refson JS; Schachter M; Hughes AD. (Nov 1995). Different effects of platelet derived growth factor isoforms on DNA synthesis and migration in human vascular smooth muscle cells. Biochem Soc Trans. 23:608S.
  • Hughes AD. (Nov 1995). Calcium channels in vascular smooth muscle cells. J Vasc Res. 32:353-370.
  • Schachter M; Betteridge LJ; Hughes AD; Patel MK. (Aug 1995). Angiotensin II receptors are exclusively of the AT1 subtype in cultured human vascular smooth muscle cells. Biochem Soc Trans. 23:458S.
  • Pickkers P; Schachter M; Sever PS; Hughes AD. (Aug 1995). Do KCa channels and carbonic anhydrase play a role in thiazide-induced hyperglycaemia?. J Hum Hypertens. 9:691-693.
  • Parkinson NA; Hughes AD. (Aug 1995). The mechanism of action of alpha 2-adrenoceptors in human isolated subcutaneous resistance arteries. Br J Pharmacol. 115:1463-1468.
  • MAYET J; STANTON AV; SINCLAIR AM; MACKAY J; SHAHI M; FOALE RA; NICOLAIDES A; POULTER NR; et alSEVER PS; THOM SAM; HUGHES AD. (1 Jul 1995). THE EFFECTS OF ANTIHYPERTENSIVE THERAPY ON CAROTID VASCULAR STRUCTURE IN MAN. CARDIOVASCULAR RESEARCH. 30:147-152. Author weblink DOI.
  • Wijetunge S; Hughes AD. (Jun 1995). Effect of platelet-derived growth factor on voltage-operated calcium channels in rabbit isolated ear artery cells. Br J Pharmacol. 115:534-538.
  • Mayet J; Shahi M; Hughes AD; Stanton AV; Poulter NR; Sever PS; Foale RA; Thom SA. (Jun 1995). Left ventricular structure and function in previously untreated hypertensive patients: the importance of blood pressure, the nocturnal blood pressure dip and heart rate. J Cardiovasc Risk. 2:255-261.
  • Clunn GF; Schachter M; Hughes AD. (May 1995). Contrasting mechanisms of intracellular calcium ([Ca2+]i) elevation by angiotensin II (AII) and platelet derived growth factor-BB (PDGF-BB) in human vascular smooth muscle cells (VSMCs). Biochem Soc Trans. 23:170S.
  • Hughes AD; Schachter M. (May 1995). AIF4- inhibits influx of Ca2+ into vascular smooth muscle cells. Biochem Soc Trans. 23:171S.
  • Garcha RS; Hughes AD. (May 1995). Inhibition of norepinephrine and caffeine-induced activation by ryanodine and thapsigargin in rat mesenteric arteries. J Cardiovasc Pharmacol. 25:840-846.
  • Toma C; Jensen PE; Prieto D; Hughes A; Mulvany MJ; Aalkjaer C. (Mar 1995). Effects of tyrosine kinase inhibitors on the contractility of rat mesenteric resistance arteries. Br J Pharmacol. 114:1266-1272.
  • Hughes AD; Patel M; Wijetunge S; Clunn G; Schachter M. (Mar 1995). Comparison of effects of platelet-derived growth factor isoforms on signaling and DNA synthesis of human cultured saphenous vein cells. J Cardiovasc Pharmacol. 25:481-485.
  • Pickkers P; Hughes AD. (Feb 1995). Relaxation and decrease in [Ca2+]i by hydrochlorothiazide in guinea-pig isolated mesenteric arteries. Br J Pharmacol. 114:703-707.
  • Hughes AD. (Jan 1995). Increase in tone and intracellular Ca2+ in rabbit isolated ear artery by platelet-derived growth factor. Br J Pharmacol. 114:138-142.
  • Hughes AD; Sinclair AM; Geroulakos G; Mayet J; Mackay J; Shahi M; Thom S; Nicolaides A; et alSever PS. (Jan 1995). Structural changes in the cardiovascular system of untreated essential hypertensives. Blood Press. 4:42-47.
  • Ibrahim J; Schachter M; Hughes AD; Sever PS. (Jan 1995). Role of polyamines in hypertension induced by angiotensin II. Cardiovasc Res. 29:50-56.
  • Munro E; Patel M; Chan P; Betteridge L; Clunn G; Gallagher K; Hughes A; Schachter M; et alWolfe J; Sever P. (Nov 1994). Inhibition of human vascular smooth muscle cell proliferation by lovastatin: the role of isoprenoid intermediates of cholesterol synthesis. Eur J Clin Invest. 24:766-772.
  • Garcha RS; Hughes AD. (16 Aug 1994). Action of heparin and ruthenium red on responses of reversibly-permeabilised rat mesenteric arteries. Eur J Pharmacol. 268:319-325.
  • Hughes AD; Clunn GF; Schachter M. (Aug 1994). A comparison of calcium channel currents in vascular smooth muscle cells from Watanabe hereditary hypercholesterolaemic and New Zealand white rabbits. Biochem Soc Trans. 22:361S.
  • Hughes AD; Wijetunge S; Parkinson NA. (Aug 1994). Isolation of single vascular smooth muscle cells from human omental resistance arteries. J Hum Hypertens. 8:615-618.
  • Hughes AD; Clunn GF; Schachter M. (May 1994). Low density lipoprotein and calcium homeostasis in human vascular smooth muscle cells. Biochem Soc Trans. 22:145S.
  • HUGHES AD. (1 May 1994). EFFECT OF PLATELET-DERIVED GROWTH-FACTOR ON TONE AND INTRACELLULAR CA2+ IN ISOLATED RABBIT EAR ARTERY. BRITISH JOURNAL OF PHARMACOLOGY. 112:U99-U99. Author weblink.
  • GARCHA RS; HUGHES AD. (1 May 1994). EVIDENCE FOR A SINGLE INTRACELLULAR CALCIUM STORE MOBILIZED BY NORADRENALINE AND CAFFEINE IN RAT ISOLATED MESENTERIC-ARTERIES. BRITISH JOURNAL OF PHARMACOLOGY. 112:U213-U213. Author weblink.
  • WIJETUNGE S; HUGHES AD. (1 May 1994). THE ACTION OF ENANTIOMERS OF AMLODIPINE ON VOLTAGE-OPERATED CALCIUM CHANNELS IN VASCULAR SMOOTH-MUSCLE CELLS. BRITISH JOURNAL OF PHARMACOLOGY. 112:U208-U208. Author weblink.
  • PARKINSON NA; WIJETUNGE S; HUGHES AD. (1 May 1994). ALPHA(2)-ADRENOCEPTOR ACTIVATION INCREASES VOLTAGE-DEPENDENT CALCIUM-CHANNEL CURRENTS IN HUMAN ARTERIAL SMOOTH-MUSCLE CELLS. BRITISH JOURNAL OF PHARMACOLOGY. 112:U111-U111. Author weblink.
  • Hughes AD; Schachter M. (Apr 1994). Multiple pathways for entry of calcium and other divalent cations in a vascular smooth muscle cell line (A7r5). Cell Calcium. 15:317-330.
  • Hughes AD; Schachter M. (Apr 1994). Hypertension and blood vessels. Br Med Bull. 50:356-370.
  • SCHACHTER M; HUGHES AD. (1 Jan 1994). EFFECT OF PLATELET-DERIVED GROWTH-FACTOR ISOFORMS ON INTRACELLULAR CA2+ IN HUMAN VASCULAR SMOOTH-MUSCLE CELLS. BRITISH JOURNAL OF PHARMACOLOGY. 111:P306-P306. Author weblink.
  • WIJETUNGE S; HUGHES AD. (1 Jan 1994). INVOLVEMENT OF G-PROTEINS IN AGONIST-INDUCED OPENING OF RECEPTOR-OPERATED CHANNELS IN VASCULAR SMOOTH-MUSCLE CELLS. BRITISH JOURNAL OF PHARMACOLOGY. 111:P265-P265. Author weblink.
  • Hughes AD; Sinclair AM; Geroulakos G; Mayet J; Mackay J; Shahi M; Thom S; Nicolaides A; et alSever PS. (Aug 1993). Structural changes in the heart and carotid arteries associated with hypertension in humans. J Hum Hypertens. 7:395-397.
  • Sinclair AM; Hughes AD; Sever PS. (Aug 1993). Effect of nifedipine and glyceryl trinitrate on retinal blood flow in normal subjects. J Hum Hypertens. 7:399-401.
  • Jensen PE; Hughes A; Boonen HC; Aalkjaer C. (Aug 1993). Force, membrane potential, and [Ca2+]i during activation of rat mesenteric small arteries with norepinephrine, potassium, aluminum fluoride, and phorbol ester. Effects of changes in pHi. Circ Res. 73:314-324.
  • Hughes AD; Wijetunge S. (May 1993). The action of amlodipine on voltage-operated calcium channels in vascular smooth muscle. Br J Pharmacol. 109:120-125.
  • Garcha RS; Sever PS; Hughes AD. (May 1993). The action of amlodipine on human subcutaneous resistance arteries studied in vitro. J Pharmacol Exp Ther. 265:860-865.
  • Sunman W; Martin G; Hair WM; Sever PS; Hughes AD. (Apr 1993). Effect of calcium antagonists on endothelin-induced contraction of isolated human resistance arteries: differences related to site of origin. J Hum Hypertens. 7:189-191.
  • Sunman W; Hughes AD; Sever PS. (Mar 1993). Free-radical scavengers, thiol-containing reagents and endothelium-dependent relaxation in isolated rat and human resistance arteries. Clin Sci (Lond). 84:287-295.
  • Wijetunge S; Aalkjaer C; Schachter M; Hughes AD. (30 Dec 1992). Tyrosine kinase inhibitors block calcium channel currents in vascular smooth muscle cells. Biochem Biophys Res Commun. 189:1620-1623.
  • WIJETUNGE S; HUGHES AD; SEVER PS. (1 Oct 1992). AMLODIPINE-INDUCED INHIBITION OF CALCIUM-CHANNEL CURRENTS IN SINGLE SMOOTH-MUSCLE CELLS ISOLATED FROM RABBIT EAR ARTERY. BRITISH JOURNAL OF PHARMACOLOGY. 107:P153-P153. Author weblink.
  • Parkinson NA; Thom SM; Hughes AD; Sever PS; Mulvany MJ; Nielsen H. (Jul 1992). Neurally evoked responses of human isolated resistance arteries are mediated by both alpha 1- and alpha 2-adrenoceptors. Br J Pharmacol. 106:568-573.
  • SUNMAN W; HUGHES AD; SEVER PS. (16 May 1992). ANAPHYLACTOID RESPONSE TO INTRAVENOUS ACETYLCYSTEINE. LANCET. 339:1231-1232. Author weblink DOI.
  • THOM S; HUGHES A; SCHACHTER M; SEVER P. (25 Jan 1992). CELIPROLOL. LANCET. 339:247-247. Author weblink DOI.
  • Garcha R; Schachter M; Hughes A; Thom SM; Sever P. (Dec 1991). Amlodipine inhibition of alpha-agonist induced contraction in human resistance vessels. J Hypertens Suppl. 9:S368-S369.
  • Aalkjaer C; Hughes A. (May 1991). Chloride and bicarbonate transport in rat resistance arteries. J Physiol. 436:57-73.
  • Videbaek LM; Aalkjaer C; Hughes AD; Mulvany MJ. (Jul 1990). Effect of pinacidil on ion permeability in resting and contracted resistance vessels. Am J Physiol. 259:H14-H22.
  • Mulvany MJ; Videbaek LM; Hughes AD; Aalkjaer C. (1990). Mechanism of the vasodilator action of pinacidil. Blood Vessels. 27:314-318.
  • VIDEBAEK LM; HUGHES A; AALKJAER C; MULVANY MJ. (1 Dec 1989). PINACIDIL - MECHANISM OF ACTION IN NORADRENALINE-ACTIVATED RAT MESENTERIC RESISTANCE VESSELS. JOURNAL OF HYPERTENSION. 7:S403-S404. Author weblink.
  • Hughes AD; Nielsen H; Sever PS. (Aug 1989). The effect of atrial natriuretic peptide on human isolated resistance arteries. Br J Pharmacol. 97:1027-1030.
  • Hughes AD; Sever PS. (Jul 1989). The action of dopamine and vascular dopamine (DA1) receptor agonists on human isolated subcutaneous and omental small arteries. Br J Pharmacol. 97:950-956.
  • Nielsen H; Thom SM; Hughes AD; Martin GN; Mulvany MJ; Sever PS. (Jul 1989). Postjunctional alpha 2-adrenoceptors mediate vasoconstriction in human subcutaneous resistance vessels. Br J Pharmacol. 97:829-834.
  • Hughes A; Sever P. (1 Mar 1989). Specific binding of 125I SCH 23982, a selective dopamine (D1) receptor ligand to plasma membranes derived from human kidney cortex. Biochem Pharmacol. 38:781-785.
  • Hughes AD; Sever PS. (1989). Action of fenoldopam, a selective dopamine (DA1) receptor agonist, on isolated human arteries. Blood Vessels. 26:119-127.
  • Hughes AD; Thom SA; Woodall N; Schachter M; Hair WM; Martin GN; Sever PS. (1989). Human vascular responses to endothelin-1: observations in vivo and in vitro. J Cardiovasc Pharmacol. 13 Suppl 5:S225-S228.
  • Hughes AD; Thom SA; Martin GN; Nielsen H; Hair WM; Schachter M; Sever PS. (Dec 1988). Size and site-dependent heterogeneity of human vascular responses in vitro. J Hypertens Suppl. 6:S173-S175.
  • Hughes A; Inkpen P; Sever P. (Mar 1988). Action of dopamine on isolated human saphenous veins. J Cardiovasc Pharmacol. 11:373-377.
  • Hughes A; Thom S; Goldberg P; Martin G; Sever P. (Feb 1988). Direct effect of alpha-human atrial natriuretic peptide on human vasculature in vivo and in vitro. Clin Sci (Lond). 74:207-211.
  • Thom S; Hughes A; Martin G; Sever PS. (Nov 1987). Endothelium-dependent relaxation in isolated human arteries and veins. Clin Sci (Lond). 73:547-552.
  • Hughes A; Martin G; Goldberg P; Thom S; Sever P. (Nov 1987). No evidence for a direct vasodilatory effect of celiprolol on human vasculature in vivo or in vitro. J Cardiovasc Pharmacol. 10:589-592.
  • Thom SA; Hughes AD; Martin GN; Sever PS. (Dec 1985). The release of the endothelium derived relaxing factor from isolated human arteries. J Hypertens Suppl. 3:S97-S99.
  • Redman D; Thom SA; Hughes AD; Hasan S; Sever PS. (Dec 1985). Human vasodilator responses to a dopamine agonist: possible mechanisms. J Hypertens Suppl. 3:S177-S178.
  • Canfield SP; Hughes AD; Price CA; Spencer JE. (1981). The action of beta-adrenoceptor agonists on acid secretion by the rat isolated stomach. 1981 Jul;316:. J Physiol. 316:23-31.
  • Torii R; Keegan J; Wood NB; Dowsey AW; Hughes AD; Yang G-Z; Firmin DN; Thom SA; et alXu Y. (2010). MR image-based geometric and hemodynamic investigation of the right coronary artery with dynamic vessel motion. Annals of Biomedical Engineering. in press.

Chapters in books

  • Hughes AD. Vascular Tone. In An Introduction to Vascular Biology: From Basic Science to Clinical Practice. 3-32. Hunt BJ (ed); Poston L (ed); Schachter M (ed); Halliday AW (ed). Cambridge University Press (2002).
  • Schachter M; Thom S; Hughes A; Martin G; Goldberg P; Sever P. Calcitonin gene related peptide - vasodilator responses in the human vasculature. In Vasodilatation: Vascular Smooth Muscle, Peptides, Autonomic Nerves and Endothelium. 475-478. Vanhoutte PM (ed). Raven Press, New York (1988).

Conferences

  • Sen S; Nijjer S; Petraco R; Broyd C; Foin N; Malik I; Mikhail G; Foale R; et alFrancis D; Hughes A; Mayet J; Davies J. STABILITY OF THE DIASTOLIC WAVE-FREE PERIOD AFTER PHARAMOCOLOGICAL PROVOCATION, AND DURING HAEMODYNAMIC PERTURBATIONS: IMPLICATIONS FOR THE CLINICAL APPLICABILITY OF THE INSTANTANEOUS WAVE-FREE RATIO (IFR). 61st Annual Scientific Session and Expo of the American-College-of-Cardiology (ACC), 24 Mar 2012 - 27 Mar 2012. 59:E1437-E1437. ELSEVIER SCIENCE INC (27 Mar 2012). Author weblink.
  • Davies JE; Sen S; Escaned J; Di Mario C; Mila R; Malik I; Francis D; Hughes A; et alMayet J. INSTANTANEOUS WAVE-FREE RATIO (IFR) HAS A SIMILAR DIAGNOSTIC EFFICIENCY TO FRACTIONAL FLOW RESERVE (FFR) IN SINGLE AND MULTI-VESSEL DISEASE: SECONDARY ANALYSIS OF ADVISE (ADENOSINE VASODILATOR INDEPENDENT STENOSIS EVALUATION) STUDY. 61st Annual Scientific Session and Expo of the American-College-of-Cardiology (ACC), 24 Mar 2012 - 27 Mar 2012. 59:E1381-E1381. ELSEVIER SCIENCE INC (27 Mar 2012). Author weblink.
  • Sen S; Francis D; Petraco R; Broyd C; Nijjer S; Foin N; Malik I; Mikhail G; et alFoale R; Hughes A; Mayet J; Davies J. SHOULD WE DISCOURAGE THE USE OF MULTI-VESSEL ANGIOPLASTY DURING STEMI OR THE USE OF REGISTRY DATA IN COMPARATIVE EFFICACY RESEARCH? AN ANALYSIS OF 35,008 PATIENTS. 61st Annual Scientific Session and Expo of the American-College-of-Cardiology (ACC), 24 Mar 2012 - 27 Mar 2012. 59:E515-E515. ELSEVIER SCIENCE INC (27 Mar 2012). Author weblink.
  • Simonsen U; Hedegaard ER; Nielsen BD; Kun A; Hughes A; Kroigaard C; Mogensen S; Frobert O. Involvement of KCNQ K channels in hypoxic vasodilatation in porcine coronary arteries. 2nd Congress of the European-Society-of-Cardiology Council on Basic Cardiovascular Science - Frontiers in Cardiovascular Biology, 30 Mar 2012 - 1 Apr 2012. 93:S30-S31. OXFORD UNIV PRESS (15 Mar 2012). Author weblink.
  • Liu D; Wood NB; Xu XY; Witt N; Hughes AD; Thom SA. Image-based Blood Flow Simulation in the Retinal Circulation. 4th European Conference of the International Federation for Medical and Biological Engineering (ECIFMBE), 23 Nov 2008 - 27 Nov 2008. 22:1963-1966. SPRINGER (1 Jan 2009).
  • Pabari PA; Kyriacou A; Moraldo M; Manisty C; Hughes AD; Mayet J; Francis DP. OPTIMISATION OF VV DELAY OF CRT IS MORE REPRODUCIBLE USING PEAK VELOCITIES THAN USING VELOCITY TIME INTEGRAL, AS WELL AS BEING QUICKER. Annual Conference of the British-Cardiovascular-Society (BCS), 13 Jun 2011 - 15 Jun 2011. 97:A50-A51. B M J PUBLISHING GROUP (1 Jun 2011). Author weblink DOI.
  • Nijjer SS; Pabari P; Stegemann B; Palmieri V; Freemantle N; Hughes A; Francis DP. PREDICTION OF RESPONSE TO BIVENTRICULAR PACING FROM DYSSYNCHRONY INDICES: THE ABSOLUTE LIMIT ON PREDICTABILITY, AND ITS CLINICAL IMPLICATIONS. Annual Conference of the British-Cardiovascular-Society (BCS), 13 Jun 2011 - 15 Jun 2011. 97:A49-A50. B M J PUBLISHING GROUP (1 Jun 2011). Author weblink DOI.
  • Pabari PA; Kyriacou A; Moraldo M; Unsworth B; Sutaria N; Mayet J; Hughes AD; Francis DP. CRT OPTIMISATION: IMPROVING ECHOCARDIOGRAPHIC TECHNIQUES BY ACCOMMODATING BIOLOGICAL VARIABILITY WITHIN DIFFERENT ECHOCARDIOGRAPHIC PARAMETERS. Annual Conference of the British-Cardiovascular-Society (BCS), 13 Jun 2011 - 15 Jun 2011. 97:A66-A67. B M J PUBLISHING GROUP (1 Jun 2011). Author weblink DOI.
  • Davies JE; Lacy PS; Cruickshank K; Stanton A; Collier D; Thurston H; Williams B; Parker KH; et alThom SM; Hughes AD. Excess pressure is higher in atenolol-treated individuals and independently predicts cardiovascular events in the CAFE substudy of ASCOT. ESC Congress, 28 Aug 2010 - 1 Sep 2010. 31:902-902. OXFORD UNIV PRESS (1 Sep 2010). Author weblink.
  • Davies JE; Sen S; Hadjiloizou N; Francis DP; Mayet J; Parker KH; Hughes AD; Chukwuemeka A; et alMikhail G; Malik IS. Reversed coronary reserve responses explain angina in severe aortic stenosis: assessment in subjects undergoing transcatheter aortic valve implantation (TAVI). ESC Congress, 28 Aug 2010 - 1 Sep 2010. 31:313-314. OXFORD UNIV PRESS (1 Sep 2010).
  • Akunuri S; Christofi F; Wijetunge S; Hughes AD. EFFECTS OF PRORENIN-DERIVED PEPTIDES ON THE PROLIFERATION OF HUMAN CULTURED SAPHENOUS VEIN SMOOTH MUSCLE CELLS. 15th Annual Meeting of the European Council for Cadiovascular Research (ECCR), 8 Oct 2010 - 10 Oct 2010. 56:1174-1174. LIPPINCOTT WILLIAMS & WILKINS (1 Dec 2010).
  • Park C; March K; Ghosh A; Tillin T; Mayet J; Chaturvedi N; Hughes A. REPRODUCIBILITY OF LEFT VENTRICULAR ENDOCARDIAL AND EPICARDIAL ROTATION BY SPECKLE TRACKING IN ELDERLY INDIVIDUALS. 15th Annual Meeting of the European Council for Cadiovascular Research (ECCR), 8 Oct 2010 - 10 Oct 2010. 56:1163-1163. LIPPINCOTT WILLIAMS & WILKINS (1 Dec 2010).
  • Sever PS; Poulter NR; Chang C-L; Thom SA; Hughes AD; Welsh P; Sattar N. The Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT): Testing C-Reactive Protein at Baseline and on-Treatment as an Independent Predictor of Cardiovascular Outcomes. American-Heart-Association Scientific Sessions 2010 on Resuscitation Science Symposium, 13 Nov 2010 - 17 Nov 2010. 122:2219-2219. LIPPINCOTT WILLIAMS & WILKINS (23 Nov 2010). Author weblink.
  • Davies J; Tillin T; Malaweera A; Lacy P; Cruickshank K; Stanton A; Collier D; Thurston H; et alWilliams B; Parker K; Thom S; Hughes A. EXCESS PRESSURE IS HIGHER IN ATENOLOL-TREATED INDIVIDUALS AND INDEPENDENTLY PREDICTS CARDIOVASCULAR EVENTS IN THE CAFE SUBSTUDY OF ASCOT. 20th Annual Meeting of the European-Society-of-Hypertension, 18 Jun 2010 - 21 Jun 2010. 28:E247-E247. LIPPINCOTT WILLIAMS & WILKINS (1 Jun 2010). Author weblink.
  • Shanmuganathan M; Baksi AJ; Francis DP; Treibel TA; Tillin T; Parker K; Hughes A; Mayet J; et alDavies JE. Meta regression analysis of aortic reflection timing to locate the site of reflection and to identify its relationship with arterial stiffness and age in 8336 subjects. 24:700-700. NATURE PUBLISHING GROUP (1 Oct 2010).
  • Sen S; Hadjiloizou N; Baksi J; Francis DP; Foale RA; Parker KH; Hughes AD; Chukwuemeka A; et alCasula R; Malik IS; Mikhail GW; Mayet J; Davies JE. Myocardial mechanism of angina in aortic stenosis identified in subjects undergoing transcatheter aortic valve implantation (TAVI). 24:689-689. NATURE PUBLISHING GROUP (1 Oct 2010).
  • Wijetunge S; Hughes AD. Src family tyrosine kinases mediate hypotonicity- induced activation of L-type calcium channels in vascular smooth muscle cells. Conference on Frontiers in Cardiovascular Biology, 16 Jul 2010 - 19 Jul 2010. 87:S61-S61. OXFORD UNIV PRESS (1 Jul 2010).
  • Christofi F; Wijetunge S; Sever PS; Hughes AD. Expression and function of the tissue renin-angiotensin system in human vascular smooth muscle cells in culture. Conference on Frontiers in Cardiovascular Biology, 16 Jul 2010 - 19 Jul 2010. 87:S60-S60. OXFORD UNIV PRESS (1 Jul 2010).
  • Sen S; Davies JE; Malik IS; Hadjiloizou N; Foale RA; Baruah R; Ghada GW; Hughes AD; et alMayet J; Francis D. WHY DOES PRIMARY ANGIOPLASTY NOT WORK IN OBSERVATIONAL STUDIES WHEN IT WORKS CONSISTENTLY IN RANDOMISED CONTROLLED TRIALS? AN ANALYSIS OF 51242 PATIENTS WITH ST ELEVATION MYOCARDIAL INFARCTION. Annual Conference and Exhibition of the British-Cardiovascular-Society, 7 Jun 2010 - 9 Jun 2010. 96:A73-A74. B M J PUBLISHING GROUP (1 Jun 2010). DOI.
  • Hadjiloizou N; Davies J; Baksi J; Malik I; Hughes A; Foale R; Parker K; Francis D; et alMayet J. DIFFERENTIAL EFFECTS OF HYPERTROPHY SECONDARY TO HYPERTENSION AND AORTIC STENOSIS ON CORONARY HAEMODYNAMICS. Annual Conference and Exhibition of the British-Cardiovascular-Society, 7 Jun 2010 - 9 Jun 2010. 96:A58-A59. B M J PUBLISHING GROUP (1 Jun 2010). Author weblink DOI.
  • Davies JE; Sen S; Hadjiloizou N; Francis DP; Foale RA; Mayet J; Parker KH; Hughes AD; et alChukwuemeka A; Mikhail G; Malik IS. ACUTE CHANGES IN CORONARY HAEMODYNAMIC IN PATIENTS UNDERGOING TRANSCATHETER AORTIC VALVE IMPLANTATION. Annual Conference and Exhibition of the British-Cardiovascular-Society, 7 Jun 2010 - 9 Jun 2010. 96:A59-A59. B M J PUBLISHING GROUP (1 Jun 2010). Author weblink DOI.
  • Stankevicius E; Kroigaard C; Boedtkjer E; Hughes AD; Mulvany MJ; Simonsen U. K plus CHANNELS AND RELEASE OF NITRIC OXIDE. 14th Annual Meeting of the European-Council-for-Cardiovascular-Research, 9 Oct 2009 - 11 Oct 2009. 54:1186-1186. LIPPINCOTT WILLIAMS & WILKINS (1 Nov 2009). Author weblink.
  • Chew FM; Wijetunge S; Hughes AD. EFFECT OF METHYLGLYOXAL ON EXPRESSION OF ENOS AND INOS IN RAT TAIL ARTERY: IMPLICATIONS FOR VASCULAR DYSFUNCTION IN DIABETES?. 14th Annual Meeting of the European-Council-for-Cardiovascular-Research, 9 Oct 2009 - 11 Oct 2009. 54:1177-1178. LIPPINCOTT WILLIAMS & WILKINS (1 Nov 2009). Author weblink.
  • Whitehead N; Tillin T; Wright A; Chaturvedi N; Hughes A. PERICARDIAL FAT, METABOLIC AND CARDIOVASCULAR RISK IN MEN OF SOUTH ASIAN AND EUROPEAN ORIGINS. 14th Annual Meeting of the European-Council-for-Cardiovascular-Research, 9 Oct 2009 - 11 Oct 2009. 54:1178-1178. LIPPINCOTT WILLIAMS & WILKINS (1 Nov 2009). Author weblink.
  • Manickavasagar M; Wijetunge S; Ramakers BP; Pickkers P; Hughes AD. EFFECTS OF ADENOSINE ON ENDOTOXIN-INDUCED VASCULAR DYSFUNCTION IN RAT TAIL ARTERIES. 14th Annual Meeting of the European-Council-for-Cardiovascular-Research, 9 Oct 2009 - 11 Oct 2009. 54:1182-1182. LIPPINCOTT WILLIAMS & WILKINS (1 Nov 2009). Author weblink.
  • Al-Hussaini A; Baksi AJ; Hadjiloizou N; Davies JE; Manisty C; Kyriacou A; Foale RA; Tillin T; et alParker KH; Francis DP; Mayet J; Hughes AD. HOW DOES WAVE INTENSITY CHANGE WITH HEART RATE? INSIGHT FROM CAROTID STUDY DURING PACING. 14th Annual Meeting of the European-Council-for-Cardiovascular-Research, 9 Oct 2009 - 11 Oct 2009. 54:1171-1171. LIPPINCOTT WILLIAMS & WILKINS (1 Nov 2009). Author weblink.
  • Strain WD; Chaturvedi NC; Rajkumar C; Bulpitt CJ; Nihoyannopoulos P; Hughes AD; Shore AC. MICROVASCULAR DYSFUNCTION IS ASSOCIATED WITH CONCENTRIC REMODELLING AND LEFT ATRIAL SIZE INDEPENDENT OF BLOOD PRESSURE AND CARDIOVASCULAR RISK FACTORS. 19th European Meeting on Hypertension, 12 Jun 2009 - 16 Jun 2009. 27:S385-S386. LIPPINCOTT WILLIAMS & WILKINS (1 Jun 2009). Author weblink.
  • Sujenthiran A; Gulati M; Wijetunge S; Hughes A. SOLUBLE ENDOGLIN INHIBITS ENDOTHELIUM-DEPENDENT RELAXATION IN RAT ISOLATED TAIL ARTERY: A POSSIBLE LINK BETWEEN PRE-ECLAMPSIA AND ENDOTHELIAL DYSFUNCTION. 19th European Meeting on Hypertension, 12 Jun 2009 - 16 Jun 2009. 27:S217-S217. LIPPINCOTT WILLIAMS & WILKINS (1 Jun 2009). Author weblink.
  • Christofi F; Wijetunge S; Sever P; Hughes A. EXPRESSION OF THE TISSUE RENIN-ANGIOTENSIN SYSTEM IN HUMAN VASCULAR SMOOTH MUSCLE CELLS (VSMC'S) IN CULTURE. 19th European Meeting on Hypertension, 12 Jun 2009 - 16 Jun 2009. 27:S452-S452. LIPPINCOTT WILLIAMS & WILKINS (1 Jun 2009). Author weblink.
  • Khir AW; Hadjiloizou N; Davies JE; Mayet J; Francis DP; Hughes AD. The Determination of Local Pulse Wave Velocity and Wave Intensity in the Human Carotid Artery: A New Noninvasive Technique. 58th Annual Scientific Session of the American-College-of-Cardiology, 28 Mar 2009 - 31 Mar 2009. 53:A214-A215. ELSEVIER SCIENCE INC (10 Mar 2009). Author weblink.
  • Sun N; Torii R; Wood NB; Hughes AD; Thom SAM; Xu XY. Computational Modeling of LDL and Albumin Transport in an In Vivo CT Image-Based Human Right Coronary Artery. ASME Summer Bioengineering Conference, 24 Jun 2007 - 28 Jun 2007. 131. ASME-AMER SOC MECHANICAL ENG (1 Feb 2009). Author weblink DOI.
  • Liu D; Wood NB; Xu XY; Witt N; Hughes AD. 3D Reconstruction of the Retinal Arterial Tree Using Subject-Specific Fundus Images. 1st ECCOMAS Thematic Conference on Computational Vision and Medical Image Processing, 17 Oct 2007 - 19 Oct 2007. 13:187-201. SPRINGER (1 Jan 2009). Author weblink.
  • Hadjiloizou N; Davies JE; Baksi AJ; Malik I; Aguado-Sierra J; Foale RA; Parker KH; Francis DP; et alHughes AD; Mayet J. Determinants of the Coronary Flow Velocity Waveforms in Aortic Stenosis. 81st Annual Scientific Session of the American-Heart-Association, 8 Nov 2008 - 12 Nov 2008. 118:S736-S736. LIPPINCOTT WILLIAMS & WILKINS (28 Oct 2008). Author weblink.
  • Torii R; Wood NB; Hadjiloizou N; Dowsey AW; Wright AR; Hughes AD; Davies J; Francis DP; et alMayet J; Yang GZ; Thom SAM; Xu XY. Differences in coronary artery haemodynamics due to changes in flow and vascular geometry after percutaneous coronary intervention. 13th Annual Meeting of the European-Council-for-Cardiovascular-Research. 52:762-762. (Oct 2008).
  • Bathula R; Hughes AD; Thom S; Panerai R; Potter J; Francis D; Shore A; Kooner J; et alChaturvedi N. Ethnic differences in sympathovagal balance and baroreceptor function are explained by dysglycaemia. 13th Annual Meeting of the European-Council-for-Cardiovascular-Research, 10 Oct 2008 - 12 Oct 2008. 52:758-758. LIPPINCOTT WILLIAMS & WILKINS (1 Oct 2008). Author weblink.
  • Beulens JW; Vingerling JR; Cruickshank JK; Hughes AD; Stanton A; Lu J; Patel A; Thom SAM; et alGrobbee DE; Stolk RP; AdRem Project Team & Adv Managemen. Effects of blood pressure lowering on incidence and progression of retinopathy in patients with type 2 diabetes mellitus: A randomised controlled trial. 44th Annual Meeting of the European-Association-for-the-Study-of-Diabetes. 51:S476-S476. (Sep 2008).
  • Tillin T; Hughes A; Godsland I; Forouhi N; McKeigue P; Chaturvedi N. Ethnic group differences in insulin resistance and dyslipidaemia be explained by differences in muscle mass and visceral fat?. 44th Annual Meeting of the European-Association-for-the-Study-of-Diabetes. 51:S175-S176. (Sep 2008).
  • Stettler C; Witt N; Tapp R; Stanton A; Thom S; Allemann S; Tillin T; Hughes AD; et alChaturvedi N. Retinal microvascular changes and risk of coronary heart disease in hypertensive diabetic and non-diabetic individuals: an ASCOT substudy. 44th Annual Meeting of the European-Association-for-the-Study-of-Diabetes. 51:S16-S16. (Sep 2008).
  • Torii R; Wood NB; Hadjiloizou N; Dowsey AW; Wright AR; Hughes AD; Davies J; Francis D; et alMayet J; Yang GZ; Thom SA; Xu XY. Differences in coronary artery haemodynamics due to changes in flow and vascular geometry after percutaneous coronary intervention. Annual Scientific Conference of the British-Cardiovascular-Society. 94:A1-A2. (Jul 2008).
  • Hadjiloiozu N; Davies J; Baksi AJ; Baruah R; Malik I; Foale R; Parker K; Hughes A; et alFrancis D; Mayet J. The importance of the microvasculature in determining the shape of the left and right coronary artery flow velocity waveform. Annual Scientific Conference of the British-Cardiovascular-Society/British-Society-for-Cardiovascular-Research, 2 Jun 2008 - 4 Jun 2008. 94:A123-A124. B M J PUBLISHING GROUP (1 Jul 2008). Author weblink.
  • Malaweera ASN; Davies JE; Hadjiloizou N; Manisty C; Aguado-Sierra J; Zambanini A; Mayet J; Francis DP; et alParker KH; Hughes AD. Peripheral pulsatile arterial pressure is determined by the central reservoir, which is similar across different arterial sites. Annual Scientific Conference of the British-Cardiovascular-Society/British-Society-for-Cardiovascular-Research, 2 Jun 2008 - 4 Jun 2008. 94:A114-A115. B M J PUBLISHING GROUP (1 Jul 2008). Author weblink.
  • Davies JE; Whinnett ZI; Hadjiloizou N; Manisty CH; Hughes AD; Parker KH; Francis DP; Mayet J. Microcirculatory-originating pressure predominantly determines coronary blood flow in humans: Evaluation using wave intensity analysis. Annual Scientific Conference of the British-Cardiovascular-Society. 94:A121-+. (Jul 2008).
  • Mansity C; Zambanini A; Poulter N; Sever P; Parker K; Thom S; Hughes A. Atorvastatin lowers augmentation index and wave reflection in hypertensive subjects: An ASCOT-LLA substudy. 18th Scientific Meeting of the European-Society-of-Hypertension/22nd Scientific Meeting of the International-Society-of-Hypertension. 26:S458-S458. (Jun 2008).
  • Davies JE; Hadjiloizou N; Manisty CH; Whinnett ZI; Francis DP; Parker KH; Mayet J; Hughes AD. Evidence to support the role of the aortic reservoir via a direct mechanism in determination of the pressure waveform with ageing. 57th Annual Scientific Session of the American-College-of-Cardiology, 29 Mar 2008 - 1 Apr 2008. 51:A339-A339. ELSEVIER SCIENCE INC (11 Mar 2008). Author weblink.
  • Hadiloizou N; Davies JE; Francis DP; Baksi AJ; Malik I; Foale R; Parker K; Hughes A; et alMayet J. Differences in intraventricular pressure can account for the variation in the flow velocity profile between the left and right coronary arteries. 57th Annual Scientific Session of the American-College-of-Cardiology, 29 Mar 2008 - 1 Apr 2008. 51:B29-B29. ELSEVIER SCIENCE INC (11 Mar 2008). Author weblink.
  • Tan FPP; Soloperto G; Wood NB; Thom S; Hughes A; Xu XY. Advanced Computational Models for Disturbed and Turbulent Flow in Stenosed Human Carotid Artery Bifurcation. 4th Kuala Lumpur International Conference on Biomedical Engineering, 25 Jun 2008 - 28 Jun 2008. 21:390-394. SPRINGER (1 Jan 2008). Author weblink.
  • Aguado-Sierra J; Davies JE; Hadjiloizou N; Francis D; Mayet J; Hughes AD; Parker KH. Reservoir-wave separation and wave intensity analysis applied to carotid arteries: A hybrid 1D model to understand haemodynamics. 30th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society, 20 Aug 2008 - 24 Aug 2008. 1381-1384. IEEE (1 Jan 2008). Author weblink DOI.
  • Liu D; Wood NB; Xu XY; Witt N; Hughes AD; Thom SAM. 3D reconstruction of the retinal arterial tree based on fundus images using a self-calibration approach. 1st ECCOMAS Thematic Conference on Computational Vision and Medical Image Processing, 17 Oct 2007 - 19 Oct 2007. 307-312. TAYLOR & FRANCIS LTD (1 Jan 2008). Author weblink.
  • Tapp R; Sharp A; Stanton A; O'Brien E; Chaturvedi N; Sever P; Poulter N; Hughes A; et alThom S; Mayet J. Left ventricular diastolic function assessed by tissue Doppler echocardiography is impaired by beta-blocker plus diuretic-based therapy compared with calcium, antagonist plus Ace inhibitor-based therapy: An ASCOT substudy. 80th Annual Scientific Session of the American-Heart-Association, 4 Nov 2007 - 7 Nov 2007. 116:609-609. LIPPINCOTT WILLIAMS & WILKINS (16 Oct 2007). Author weblink.
  • Hughes A; Manisty C; Zambanini A; Mayet J; Poulter N; Sever P; Parker K; Thom S. Lower augmentation index and wave reflection in hypertensive subjects treated with atorvastatin; An ASCOT-LLA substudy. 80th Annual Scientific Session of the American-Heart-Association, 4 Nov 2007 - 7 Nov 2007. 116:609-609. LIPPINCOTT WILLIAMS & WILKINS (16 Oct 2007). Author weblink.
  • Oakland KA; Schachter M; Hughes AD. Comparison of the effects of cysteine and homocysteine on endothelial progenitor cells in vitro. 12th Annual Meeting of the European-Council-for-Cardiovascular-Research, 12 Oct 2007 - 14 Oct 2007. 50:811-811. LIPPINCOTT WILLIAMS & WILKINS (1 Oct 2007). Author weblink.
  • Peterzan MA; Chaturvedi N; Hughes AD. Dose-relationships of blood pressure and metabolic effects of hydrochlorothiazide, chlorthalidone and bendroflumethiazide monotherapy: A meta-analysis. 12th Annual Meeting of the European-Council-for-Cardiovascular-Research. 50:818-818. (Oct 2007).
  • Alakakone A; Tillin T; Chambers J; Malik I; Coady E; Raynor S; Mayet J; Wright A; et alKooner J; Shore A; Thom S; Chaturvedi N; Hughes A. Do differences in lower limb blood flow explain the ethnic disparity in peripheral arterial disease incidence between South Asians and Europeans?. 12th Annual Meeting of the European-Council-for-Cardiovascular-Research. 50:803-803. (Oct 2007).
  • Patel S; Bathula R; Page C; Tillin T; Chaturvedi N; Godsland I; Potter J; Panerai RB; et alHughes AD. Cerebrovascular effects of an oral glucose tolerance test. 12th Annual Meeting of the European-Council-for-Cardiovascular-Research, 12 Oct 2007 - 14 Oct 2007. 50:800-800. LIPPINCOTT WILLIAMS & WILKINS (1 Oct 2007). Author weblink.
  • Simonsen U; Krojgaard C; Stankevicius E; Schjorring O; Litvin K; Hughes A. A novel opener of small and intermediate calcium-activated K channels releases NO and causes EDHF type vasodilatation in rat mesenteric arteries. 12th Annual Meeting of the European-Council-for-Cardiovascular-Research, 12 Oct 2007 - 14 Oct 2007. 50:802-802. LIPPINCOTT WILLIAMS & WILKINS (1 Oct 2007). Author weblink.
  • Joshi M; Tillin T; Malik I; Coady E; Raynor S; Mayet J; Wright A; Kooner J; et alShore A; Thom S; Chaturvedi N; Hughes A. Associations between lower limb arterial calcification and markers of coronary and peripheral arterial disease in South Asian and European men. 12th Annual Meeting of the European-Council-for-Cardiovascular-Research, 12 Oct 2007 - 14 Oct 2007. 50:819-820. LIPPINCOTT WILLIAMS & WILKINS (1 Oct 2007). Author weblink.
  • Sujenthiran A; Wijetunge S; Hughes AD. Soluble endoglin causes impaired endothelium dependent relaxation in rat tail artery: A possible pathogenic mechanism in pre-eclampsia. 12th Annual Meeting of the European-Council-for-Cardiovascular-Research. 50:810-810. (Oct 2007).
  • Stolk RP; van Schooneveld MJ; Cruickshank K; Hughes AD; Stanton A; Juming L; Patel A; Thom SAM; et alVingerling JR; Grobbee DE. Retinal vascular lesions in patients with type 2 diabetes mellitus of Caucasian and Asian origin: baseline results from the AdRem study. 43rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes. 50:S447-S447. (Sep 2007).
  • Davies J; Hadjiloizou N; Manisty C; Whinnett Z; Foale R; Malik I; Hughes A; Parker K; et alDarrel D; Mayet J. A unifying explanation of the arterial pulse waveform in humans and the implications for central blood pressure augmentation. Annual Scientific Conference of the British-Cardiovascular-Society, 4 Jun 2007 - 7 Jun 2007. 93:A79-A80. B M J PUBLISHING GROUP (1 Jun 2007). Author weblink.
  • Manisty C; Davies J; Whinnett Z; Francis D; Zambanini A; Zambanini A; Curtis S; Thom S; et alHughes A; Mayet J. Differences in the magnitude rather than the timing of wave reflection can explain the ASCOT results. Annual Scientific Conference of the British-Cardiovascular-Society, 4 Jun 2007 - 7 Jun 2007. 93:A80-A80. B M J PUBLISHING GROUP (1 Jun 2007). Author weblink.
  • Davies JE; Francis DP; Manisty CH; Hadjiloizou N; Aguado-Sierra J; Malik IS; Foale RA; Hughes AD; et alParker KH; Mayet J. A unifying explanation of the aortic pulse waveform in humans. 56th Annual Scientific Session of the American-College-of-Cardiology, 24 Mar 2007 - 27 Mar 2007. 49:397A-398A. ELSEVIER SCIENCE INC (6 Mar 2007). Author weblink.
  • Sun N; Torii R; Wood NB; Wright A; Hughes AD; Thom SAM; Xu XY. Numerical simulation of blood-wall albumin transport in a realistic human right coronary artery. ASME Summer Bioengineering Conference, 24 Jun 2007 - 28 Jun 2007. 107-108. AMER SOC MECHANICAL ENGINEERS (1 Jan 2007). Author weblink.
  • Torii R; Wood NB; Hadjiloizou N; Wright A; Hughes AD; Thom SAM; Xu XY. Does the difference in realistic waveform before and after stenting affect hemodynamics in stenosed coronary artery?. ASME Summer Bioengineering Conference, 24 Jun 2007 - 28 Jun 2007. 467-468. AMER SOC MECHANICAL ENGINEERS (1 Jan 2007). Author weblink.
  • Manisty CH; Willson K; Davies JE; Whinnett ZI; Oldfield WLG; Hughes A; Mayet J; Francis DP. Can cardiac pacemakers directly control ventilation?. Winter Meeting of the British-Thoracic-Society/British-Lung-Foundation (BTS/BLF). 61:II49-II49. (Dec 2006).
  • Manisty CH; Davies JE; Zambanini A; Curtis SL; Whinnett ZI; Thom SM; Francis DP; Hughes A; et alMayet J. Differential arterial wave reflection in ASCOT: An explanation for the results?. 79th Annual Scientific Session of the American-Heart-Association. 114:537-537. (31 Oct 2006).
  • Bathula R; Chaturvedi N; Hughes A; Coady E; Francis D. Ethnic differences in heart rate variability unexplained by conventional risk factors. 11th Annual Meeting of the European-Council- for Cardiovascular Reseach. 48:781-781. (Oct 2006).
  • Davies JE; Hadjiloizou N; Whinnett ZI; Francis DP; Manisty CH; Hughes AD; Parker KH; Mayet J. Evidence to support the augmentation of coronary blood flow in systole, by wave reflection from the aorta. World Congress of Cardiology, 2 Sep 2006 - 6 Sep 2006. 27:512-512. OXFORD UNIV PRESS (1 Aug 2006). Author weblink.
  • Whinnett ZI; Davies JER; Briscoe KA; Willson K; Manisty CH; Hughes AD; Mayet J; Francis DP. Optimisation of the atrioventricular delay of cardiac resynchronisation determined during exercise can be predicted by a resting pacing model. World Congress of Cardiology. 27:193-193. (Aug 2006).
  • Tillin T; Dhutia H; Chambers J; Malik I; Coady E; Mayet J; Wright A; Kooner J; et alChaturvedi N; Hughes A. British South Asian men have more adverse plaque morphology despite equivalent atherosclerotic burden to White Europeans. 14th Meeting of the International-Society-of-Atherosclerosis, 18 Jun 2006 - 22 Jun 2006. 7:80-80. ELSEVIER IRELAND LTD (1 Jun 2006). Author weblink DOI.
  • Tillin T; Dhutia H; Chambers J; Malik I; Coady E; Mayet J; Wright A; Kooner J; et alChaturvedi N; Hughes A. South Asians have narrower coronary arteries and different remodelling responses to disease compared to white Europeans. 14th Meeting of the International-Society-of-Atherosclerosis, 18 Jun 2006 - 22 Jun 2006. 7:80-80. ELSEVIER IRELAND LTD (1 Jun 2006). Author weblink DOI.
  • Chaturvedi N; Coady E; Mayet J; Wright AR; Shore AC; Thom SAMCG; Kooner J; Hughes AD. Femoral atherosclerosis is reduced in South Asian compared with European men. 14th Meeting of the International-Society-of-Atherosclerosis, 18 Jun 2006 - 22 Jun 2006. 7:104-104. ELSEVIER IRELAND LTD (1 Jun 2006). Author weblink DOI.
  • Davies J; Whinnett Z; Francis D; Manisty C; Willson K; Foale R; Malik I; Hughes A; et alParker K; Mayet J. Coronary blood flow is not augmented by aortic wave reflection: An invasive assessment using wave intensity analysis. Annual Scientific Conference of the British-Society-Promoting-Cardiovascular-Health, 24 Apr 2006 - 27 Apr 2006. 92:A35-A35. B M J PUBLISHING GROUP (1 May 2006). Author weblink.
  • Sharp A; Thom S; Francis D; Hughes A; Stanton A; Zambanini A; O'Brien E; Lyons S; et alByrd S; Poulter N; Sever P; Mayet J. Ethnicity and left ventricular diastolic function in hypertension: An ASCOT substudy. Annual Scientific Conference of the British-Society-Promoting-Cardiovascular-Health. 92:A34-A34. (May 2006).
  • Whinnett Z; Davies J; Briscoe C; Willson K; Foale R; Davies D; Hughes A; Mayet J; et alFrancis D. By pacing at increased rates at rest it is possible to predict the haemodynamic optimal atrioventricular delay of biventricular pacing determined during exercise. Annual Scientific Conference of the British-Society-Promoting-Cardiovascular-Health. 92:A113-A114. (May 2006).
  • Sharp A; Mayet J; Francis D; Hughes A; Stanton A; Kyd P; Zambanini A; Poulter N; et alSever P; Thom S. The effect of ethnicity on BNP levels in hyplkiension - An ASCOT sub-study. Annual Scientific Conference of the British-Society-Promoting-Cardiovascular-Health, 24 Apr 2006 - 27 Apr 2006. 92:A49-A49. B M J PUBLISHING GROUP (1 May 2006). Author weblink.
  • Davies J; Whinnett Z; Francis D; Manisty C; Willson K; Foale R; Malik I; Hughes A; et alParker K; Mayet J. Evidence of a dominant backward-propagating "suction" wave, responsible for diastolic coronary filling in humans, attenuated in left ventricular hypertrophy. Annual Scientific Conference of the British-Society-Promoting-Cardiovascular-Health, 24 Apr 2006 - 27 Apr 2006. 92:A2-A3. B M J PUBLISHING GROUP (1 May 2006). Author weblink.
  • Manisty C; Davies J; Francis D; Zambanini A; Thom S; Hughes A; Mayet J. The protodiastolic expansion wave: A compensatory mechanism for the reduction in longitudinal relaxation velocity with ageing?. Annual Scientific Conference of the British-Society-Promoting-Cardiovascular-Health, 24 Apr 2006 - 27 Apr 2006. 92:A61-A62. B M J PUBLISHING GROUP (1 May 2006). Author weblink.
  • Manisty C; Davies J; Willson K; Whinnett Z; Hughes A; Mayet J; Francis D. Harnessing physiological cardiorespiratory interaction to modulate ventilation by dynamic changes in cardiac output. Annual Scientific Conference of the British-Society-Promoting-Cardiovascular-Health, 24 Apr 2006 - 27 Apr 2006. 92:A39-A40. B M J PUBLISHING GROUP (1 May 2006). Author weblink.
  • Sharp A; Thom S; Francis D; Hughes A; Stanton A; Zombanini A; O'Brien E; Lyons S; et alLang C; Byrd S; Poulter N; Sever P; Mayet J. The ability of tissue Doppler echocardiography to predict future cardiovascular events in a hypertensive population: An ASCOT substudy. Annual Scientific Conference of the British-Society-Promoting-Cardiovascular-Health, 24 Apr 2006 - 27 Apr 2006. 92:A34-A35. B M J PUBLISHING GROUP (1 May 2006). Author weblink.
  • Whinnett Z; Davies J; Willson K; Manisty C; Chow A; Foale R; Davies D; Hughes A; et alMayet J; Francis D. Changes in atrioventricular delay of cardiac resynchronisation therapy have a significantly larger haemodynamic effect compared with altering interventricular delay. Annual Scientific Conference of the British-Society-Promoting-Cardiovascular-Health, 24 Apr 2006 - 27 Apr 2006. 92:A114-A115. B M J PUBLISHING GROUP (1 May 2006). Author weblink.
  • Manisty C; Davies J; Whinnett Z; Francis D; Zambanini A; Cunningham S; Thom S; Hughes A; et alMayet J. The role of wave reflection in the pathophysiology of hypertension: Assessed using non-invasive wave intensity analysis. Annual Scientific Conference of the British-Society-Promoting-Cardiovascular-Health. 92:A33-A33. (May 2006).
  • Whinnett ZI; Davies JER; Willson K; Manisty CH; Chow AW; Foale RA; Davies DW; Hughes AD; et alMayet J; Francis DP. The haemodynamic response to changes in atrioventricular and interventricular delay of cardiac resynchronization therapy closely fits a parabola, which may allow more efficient optimization. 55th Annual Scientific Session of the American-College-of-Cardiology, 11 Mar 2006 - 14 Mar 2006. 47:22A-22A. ELSEVIER SCIENCE INC (21 Feb 2006). Author weblink.
  • Khir AW; Hughes AD; Parker KH. The inflection point is not a reliable method for the determination of the augmentation index. 55th Annual Scientific Session of the American-College-of-Cardiology, 11 Mar 2006 - 14 Mar 2006. 47:315A-315A. ELSEVIER SCIENCE INC (21 Feb 2006). Author weblink.
  • Tapp R; Sharp A; Chaturvedi N; Stanton A; Mayet J; Hughes A; Thom S. Effects of blood pressure lowering with beta blocker plus diuretic-based therapy and calcium antagonist plus angiotensin converting enzyme inhibitor-based therapy on left ventricular diastolic function. 78th Annual Scientific Session of the American-Heart-Association. 112:U399-U400. (25 Oct 2005).
  • Nielsen BD; Frobert O; Clunn G; Hughes AD; Simonsen U. Involvement of cyclic nucleotides and potassium channels in hypoxic vasodilatation in pig coronary arteries. 10th Annual Meeting of the European-Council-for-Cardiovascular-Research, 14 Oct 2005 - 16 Oct 2005. 46:909-910. LIPPINCOTT WILLIAMS & WILKINS (1 Oct 2005). Author weblink.
  • Hughes AD; Coady E; Byrd S; Mayet J; Wright A; Shore A; Kooner J; Thom SA. Circulating endothelial progenitor cells and atherosclerosis in European and South Asian subjects. 10th Annual Meeting of the European-Council-for-Cardiovascular-Research. 46:900-900. (Oct 2005).
  • Kox M; Wijetunge S; Pickkers P; Hughes AD. The role of SRC-family tyrosine kinases in the effects of lipopolysaccharide on rat isolated tail arteries. 10th Annual Meeting of the European-Council-for-Cardiovascular-Research. 46:909-909. (Oct 2005).
  • Wijetunge S; Hughes AD. SRC-family tyrosine kinase(s) is involved in hyposmotic swelling-induced contraction of rat tail arteries. 15th European Meeting on Hypertension. 23:S347-S347. (Jun 2005).
  • Davies J; Whinnett Z; Francis D; Willson K; Foale R; Malik I; Thom S; Hughes A; et alParker K; Mayet J. Effect of nitrate administration on wave speed propagation in the human coronary artery. Annual Conference of G-MEX/MICC. 91:A66-A67. (May 2005).
  • Whinnett Z; Davies J; Willson K; Chow A; Foale R; Davies W; Hughes A; Francis D; et alMayet J. Optimisation of atrioventricular (AV) and interventricular (VV) delay in biventricular pacing using continuous non-invasive measurement of blood pressure (BP). Annual Conference of G-MEX/MICC, 23 May 2005 - 26 May 2005. 91:A52-A53. B M J PUBLISHING GROUP (1 May 2005). Author weblink.
  • Nilsson H; Rahman A; Hughes A; Aalkjaer C. A heterocellular oscillator in the vascular wall?. Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences, 31 Mar 2005 - 6 Apr 2005. 19:A1629-A1629. FEDERATION AMER SOC EXP BIOL (7 Mar 2005). Author weblink.
  • Davies JE; Whinnett ZI; Francis DP; Willson K; Foale RA; Malik L; Hughes AD; Parker KH; et alMayet J. Effect of left ventricular hypertrophy on human coronary artery haemodynamics. 54th Annual Scientific Session of the American-College-of-Cardiology, 6 Mar 2005. 45:431A-431A. ELSEVIER SCIENCE INC (1 Feb 2005). Author weblink.
  • Whinnett ZI; Davies JER; Willson K; Chow AW; Foale RA; Davies DW; Hughes AD; Francis DP; et alMayet J. Continuous non-invasive hemodynamic monitoring to optimize atrioventricular delay in cardiac resychronization therapy. 54th Annual Scientific Session of the American-College-of-Cardiology. 45:99A-99A. (1 Feb 2005).
  • Sharp A; Thom S; Hughes A; Francis D; Stanton A; O'Brien E; Fitzgerald D; Shields D; et alPoulter N; Sever P; Mayet J. Black hypertensives have significantly lower B-Natriuretic peptide levels than South Asians or Whites. 54th Annual Scientific Session of the American-College-of-Cardiology, 6 Mar 2005. 45:381A-381A. ELSEVIER SCIENCE INC (1 Feb 2005). Author weblink.
  • Ho E; Rooney C; Harhen B; Sever P; Poulter N; Hughes A; Thom S; O'Brien E; et alFitzgerald D; Stanton A. Atherosclerosis and oxidative stress contribute to aspirin nonresponse in hypertensive subjects. 77th Scientific Meeting of the American-Heart-Association, 7 Nov 2004 - 10 Nov 2004. 110:608-608. LIPPINCOTT WILLIAMS & WILKINS (26 Oct 2004). Author weblink.
  • Augst A; Ariff B; Barratt D; Thom SAM; Xu XY; Hughes AD. Blood pressure not shear stress is related to intima-media thickness (IMT) over the entire carotid bifurcation. 9th Annual Meeting of the European Council for Cardiovascular Research. 44:566-566. (Oct 2004).
  • Packianathan S; Schachter M; Gallagher KL; Hughes AD. The effect of statins on vascular endothelial growth factor in human endothelial progenitor cells. 9th Annual Meeting of the European Council for Cardiovascular Research, 1 Oct 2004 - 3 Oct 2004. 44:587-587. LIPPINCOTT WILLIAMS & WILKINS (1 Oct 2004). Author weblink.
  • Debney MT; Hughes AD; Thom SAM; Strain WD; Chaturvedi N. Explanations for the elevated stroke risk in south Asians. 9th Annual Meeting of the European Council for Cardiovascular Research. 44:573-573. (Oct 2004).
  • Dotsenko O; Barratt D; Thom SAM; Hughes AD. Reproducibility of 3D-ultrasound assessment of stenotic carotid arteries using anthropomorphic phantoms. 9th Annual Meeting of the European Council for Cardiovascular Research. 44:588-588. (Oct 2004).
  • Clunn GF; Patel MK; Hughes AD. Regulation of p38 mitogen activated protein kinase by calcium influx in human vascular smooth muscle cells. 9th Annual Meeting of the European Council for Cardiovascular Research. 44:588-588. (Oct 2004).
  • Wijetunge S; Hughes AD. Mechanism of contraction of rat isolated tail arteries by hyposmotic solutions. 9th Annual Meeting of the European Council for Cardiovascular Research, 1 Oct 2004 - 3 Oct 2004. 44:588-588. LIPPINCOTT WILLIAMS & WILKINS (1 Oct 2004). Author weblink.
  • Thom SAM; Mistry P; Sjolie A; Larsen B; Witt N; Hughes AD. Retinal vascular adaptations to blood pressure are impaired in Type 1 diabetes. 40th Annual Meeting of the European-Association-for-the-Study-of-Diabetes. 47:A49-A49. (Aug 2004).
  • Starmans-Kool M; Stanton A; Thom S; Hughes A. The effect of salt intake on arterio-ventricular function and wave reflection in the carotid artery. 14th European Meeting on Hypertension. 22:S299-S299. (Jun 2004).
  • Fexby S; Hughes AD; Lymn JS. Tissue transglutaminase and phospholipase C-delta 1 are complexed in human vascular smooth muscel cells after serum deprivation. 14th European Meeting on Hypertension, 13 Jun 2004 - 17 Jun 2004. 22:S351-S351. LIPPINCOTT WILLIAMS & WILKINS (1 Jun 2004).
  • Hughes A; Ariff B; Stanton A; Xu Y; Sever P; Thom S. Differential efects of antihypertensive drugs on vascular structure. 14th European Meeting on Hypertension, 13 Jun 2004 - 17 Jun 2004. 22:S201-S201. LIPPINCOTT WILLIAMS & WILKINS (1 Jun 2004). Author weblink.
  • Wijetunge S; Hughes A. Hypo-osmotic swelling-induced contraction of rat tail arteries involves CaV1.2 calcium channels and protein tyrosine kinase. 14th European Meeting on Hypertension, 13 Jun 2004 - 17 Jun 2004. 22:S203-S204. LIPPINCOTT WILLIAMS & WILKINS (1 Jun 2004). Author weblink.
  • Dotsenko O; Barratt D; Ariff B; Thom S; Hughes A. Vascular geometry reconstruction with 3D ultrasound, applied to anthropomorphic phantoms models. 14th European Meeting on Hypertension, 13 Jun 2004 - 17 Jun 2004. 22:S13-S13. LIPPINCOTT WILLIAMS & WILKINS (1 Jun 2004). Author weblink.
  • Ariff B; Zambanini A; Sarita V; Barratt D; Xu Y; Sever P; Chaturvedi N; Stanton A; et alThom S; Hughes A. Hemodynamic determinants of carotid artery structure in essential hypertension. 19th Annual Scientific Meeting of the American-Society-of-Hypertension, 18 May 2004 - 22 May 2004. 17:131A-132A. ELSEVIER SCIENCE INC (1 May 2004). Author weblink.
  • Ho E; Rooney C; Harhen B; Sever P; Hughes A; Thom S; Fitzgerald D; Stanton A. Doubling of isoprostane formation in a large cohort of hypertensive patients despite optimal medical management. 20th ISH Meeting, 15 Feb 2004 - 19 Feb 2004. 22:S43-S43. LIPPINCOTT WILLIAMS & WILKINS (1 Feb 2004). Author weblink.
  • Clunn GF; Patel MK; Hughes AD. Regulation of p38 mitogen activated protein kinase by calcium influx in human vascular smooth muscle cells. 20th ISH Meeting, 15 Feb 2004 - 19 Feb 2004. 22:S76-S77. LIPPINCOTT WILLIAMS & WILKINS (1 Feb 2004). Author weblink.
  • Sharp AS; Zambanini A; Hughes AD; Byrd S; Shields D; Fitzgerald D; Lyons S; O'Brien E; et alStanton A; Poulter N; Sever PS; Thom SAG; Mayet J. Atorvastatin does not reduce LV mass or affect diastolic function after one year of treatment. Meeting of the British Society of Echocardiography. 89:41-42. (Nov 2003).
  • Cunningham SL; Mayet J; Parker KH; Foale RA; Thom SAM; Hughes AD. Wave intensity analysis: Insights in haemodynamic abnormalities in heart failure. Meeting of the British Society of Echocardiography. 89:37-37. (Nov 2003).
  • Ariff B; Zambanini A; Vamadeva S; O'Neill A; Stanton A; Xu Y; Hughes A; Thom S. Differing effects of candesartan cilexetil and atenolol on carotid artery remodelling and carotid flow in hypertension. 76th Annual Scientific Session of the American-Heart-Association, 7 Nov 2003 - 12 Nov 2003. 108:452-452. LIPPINCOTT WILLIAMS & WILKINS (28 Oct 2003). Author weblink.
  • Wijetunge S; Hughes AD. Role of voltage-operated calcium channels and tyrosine kinases in the contaction of rat isolated tail artery by hyposmotic conditions. 8th Annual Meeting of the European-Council-for-Blood-Pressure-and-Cardiovascular-Research (ECCR). 42:647-647. (Oct 2003).
  • Ariff B; O'Neill A; Stanton A; Zambanini A; Vamadeva S; Poulter N; Sever P; Xu Y; et alHughes A; Thom S. Candesartan cilexetil & atenolol have different effects on common carotid artery remodelling in hypertension. 13th European Meeting on Hypertension, 13 Jun 2003 - 17 Jun 2003. 21:S153-S154. LIPPINCOTT WILLIAMS & WILKINS (1 Jun 2003). Author weblink.
  • Glor FP; Ariff B; Augst AD; Barratt DC; Hughes AD; Thom SAM; Verdonck P; Xu XY. 3D ultrasound-based CFD for carotid flow prediction: a reproducibility study. 2nd MIT Conference on Computational Fluid and Solid Mechanics. 1701-1704. (2003).
  • Ariff B; O'Neill A; Xu Y; Stanton A; Sever P; Hughes A; Thom S. Divergent effects on cardiac and vascular structure in hypertensive subjects treated with candesartan and atenolol. American-Heart-Association Abstracts From Scientific Sessions, 17 Nov 2002 - 20 Nov 2002. 106:575-575. LIPPINCOTT WILLIAMS & WILKINS (5 Nov 2002). Author weblink.
  • Ali Z; Hughes AD; Lymn JS. Analysis of the migrational ability of vascular smooth muscle cells derived from hypertensive rats compared to normotensive controls. 7th Annual Meeting of the European-Council-for-Blood-Pressure-and-Cardiovascular-Research, 11 Oct 2002 - 13 Oct 2002. 40:580-580. LIPPINCOTT WILLIAMS & WILKINS (1 Oct 2002). Author weblink.
  • Fexby S; Harrington LS; Hughes AD; Lymn JS. A role for tissue transglutaminase in regulating PLC delta(1) in VSMC. 7th Annual Meeting of the European-Council-for-Blood-Pressure-and-Cardiovascular-Research. 40:580-580. (Oct 2002).
  • Hassan M; Stanton AV; Mistry P; Martinez-Perez E; Parker KH; Sever PS; Thom SAM; Hughes AD. Effect of antihypertensive treatment on hypertensive changes in the human retina. 7th Annual Meeting of the European-Council-for-Blood-Pressure-and-Cardiovascular-Research, 11 Oct 2002 - 13 Oct 2002. 40:569-569. LIPPINCOTT WILLIAMS & WILKINS (1 Oct 2002). Author weblink.
  • Jackson MJM; Ariff BB; Zambanini A; Wolfe JHN; Hughes AD; Thom SAM. In-vivo estimation of shear stress in autologous vein bypass grafts. 7th Annual Meeting of the European-Council-for-Blood-Pressure-and-Cardiovascular-Research. 40:574-574. (Oct 2002).
  • Harrington LS; Gallagher K; Hughes AD; Lymn JL. The effects of serum deprivation on human vascular smooth muscle cells: a time course investigating DNA synthesis and PLC isoform expression. 7th Annual Meeting of the European-Council-for-Blood-Pressure-and-Cardiovascular-Research. 40:580-580. (Oct 2002).
  • Harrington LS; Hughes AD; Lymn JL. The effects of organ culture on contractility and PLC delta 1 expression in rat mesenteric arteries. 7th Annual Meeting of the European-Council-for-Blood-Pressure-and-Cardiovascular-Research, 11 Oct 2002 - 13 Oct 2002. 40:580-580. LIPPINCOTT WILLIAMS & WILKINS (1 Oct 2002). Author weblink.
  • Ariff B; O'Neill A; Xu XY; Sever PS; Stanton AV; Hughes AD; Thom SM. Divergent effects on cardiac and carotid vascular remodelling in hypertensive subjects treated with candesartan cilexitil & atenolol. 7th Annual Meeting of the European-Council-for-Blood-Pressure-and-Cardiovascular-Research, 11 Oct 2002 - 13 Oct 2002. 40:582-582. LIPPINCOTT WILLIAMS & WILKINS (1 Oct 2002). Author weblink.
  • Augst AD; Barratt DC; Hughes AD; Thom SA; Xu XY. CFD modeling of carotid bifurcation blood flow using 3D ultrasound. 7th Annual Meeting of the European-Council-for-Blood-Pressure-and-Cardiovascular-Research. 40:571-571. (Oct 2002).
  • Glor FP; Long Q; Hughes AD; Augst AD; Ariff B; Thom SAM; Verdonck P; Xu XY. MR based CFD cardiovascular modelling: a reproducibility study on carotid blood flow. 7th Annual Meeting of the European-Council-for-Blood-Pressure-and-Cardiovascular-Research. 40:582-582. (Oct 2002).
  • Harrington LS; Hughes AD; Lymn JS. Effects of organ culture on contractility and phospholipase C isoform expression of rat mesenteric arteries. Conference of the Physiological-Society, 8 Jul 2002 - 11 Jul 2002. 543:73P-73P. CAMBRIDGE UNIV PRESS (1 Oct 2002). Author weblink.
  • Byrd SM; Zambanini A; Hughes AD; Thom SAM. Cerebrovascular haemodynamic mapping (CHM) - a novel approach for stroke risk stratification. 7th Annual Meeting of the European-Council-for-Blood-Pressure-and-Cardiovascular-Research. 40:588-588. (Oct 2002).
  • Fexby S; Harrington LS; Hodson E; Hughes AD; Lymn JS. A possible role for tissue transglutaminase in regulating PLC delta(1) in human vascular smooth muscle cells (HVSMC). Conference of the Physiological-Society, 8 Jul 2002 - 11 Jul 2002. 543:84P-84P. CAMBRIDGE UNIV PRESS (1 Oct 2002). Author weblink.
  • Lymn JS; Patel MK; Clunn GF; Hughes AD. Platelet derived growth factor induces proliferation via a novel Wortmannin-independent phosphatidylinositol 3-kinase. 19th Meeting of the International-Society-for-Hypertension/12th European-Society-of-Hypertension Meeting. 20:S116-S116. (Jun 2002).
  • Harrington LS; Hughes AD; Lymn JS. Effects of organ culture on contractility and phospholipase C isoform expression of rat mesenteric arteries. 19th Meeting of the International-Society-for-Hypertension/12th European-Society-of-Hypertension Meeting. 20:S116-S117. (Jun 2002).
  • Wijetunge VS; Dolphin AC; Hughes AD. Tyrosine kinases modulate voltage-operated calcium channels expressed in COS-7 cells via the alpha(1) pore-forming subunit. 19th Meeting of the International-Society-for-Hypertension/12th European-Society-of-Hypertension Meeting. 20:S280-S280. (Jun 2002).
  • Stanton A; Ghiuzeli C; Chapman N; Hughes A; Thom S. Human retinal arteriolar dilatation occurs with blood pressure lowering with amlodipine but not with lisinopril. 19th Meeting of the International-Society-for-Hypertension/12th European-Society-of-Hypertension Meeting, 23 Jun 2002 - 27 Jun 2002. 20:S73-S73. LIPPINCOTT WILLIAMS & WILKINS (1 Jun 2002). Author weblink.
  • Harrington LS; Patel MK; Hughes AD; Lymn JS. Association between phospholipase C isoform expression and differentiation status of vascular smooth muscle cells. 19th Meeting of the International-Society-for-Hypertension/12th European-Society-of-Hypertension Meeting. 20:S116-S116. (Jun 2002).
  • Clunn GF; Patel MK; Sever PS; Hughes AD. Roles of Rho-kinase and p38 mitogen activated protein kinase pathways in control of human smooth muscle cell chemotaxis and morphology. 19th Meeting of the International-Society-for-Hypertension/12th European-Society-of-Hypertension Meeting. 20:S176-S176. (Jun 2002).
  • Garcha RS; Hughes AD. C-type natriuretic peptide is a potent vasorelaxant in human subcutaneous resistance arteries. 19th Meeting of the International-Society-for-Hypertension/12th European-Society-of-Hypertension Meeting. 20:S12-S12. (Jun 2002).
  • Fexby S; Wimalasundra R; Hughes AD. Comparison of histamine- and acetylcholine-induced relaxation in rat isolated mesenteric small arteries. 19th Meeting of the International-Society-for-Hypertension/12th European-Society-of-Hypertension Meeting. 20:S289-S289. (Jun 2002).
  • Gao XH; Bharath A; Stanton A; Hughes A; Chapman N; Thom S. A method of vessel tracking for vessel diameter measurement on retinal images. International Conference on Image Processing (ICIP 2001), 7 Oct 2001 - 10 Oct 2001. 881-884. IEEE (1 Jan 2001). Author weblink.
  • Pratsinis H; Demoliou-Mason C; Hughes A; Kletsas D. A novel in vitro model of conditionally immortalized human vascular smooth muscle cells - A tool for aging studies. EMBO Workshop on Molecular and Cellular Gerontology. 908:321-323. (2000).
  • Martinez-Perez ME; Hughes AD; Stanton AV; Thom SA; Chapman N; Bharath AA; Parker KH. Geometrical and morphological analysis of vascular branches from fundus retinal images. 3rd International Conference on Medical Image Computing and Computer-Assisted Intervention. 1935:756-765. (2000).
  • Zhao SZ; Xu XY; Collins MW; Stanton AV; Hughes AD; Thom SA. The convergence technique in numerical solutions of coupled fluid-wall problems. Conference on Cardiovascular Flow Modelling and Measurement with Application to Clinical Medicine, Sep 1998. 70:125-134. OXFORD UNIVERSITY PRESS (1 Jan 1999). Author weblink.
  • Martinez-Perez ME; Hughes AD; Stanton AV; Thom SA; Bharath AA; Parker KH. Retinal blood vessel segmentation by means of scale-space analysis and region growing. 2nd International Conference on Medical Image Computing and Computer-Assisted Intervention (MICCAI 99), 19 Sep 1999 - 22 Sep 1999. 1679:90-97. SPRINGER-VERLAG BERLIN (1 Jan 1999). Author weblink.
  • Gao XH; Bharath AA; Hughes A; Stanton A; Chapman N; Thom S. Towards retinal vessel parameterisation. Medical Imaging 1997 Symposium - Image Processing. 3034:734-744. (1997).
  • Patel MK; Clunn GF; Lymn JS; Hughes AD. Thrombospondin-1 induces DNA synthesis and migration in human vascular smooth muscle cells. 658th Meeting of the Biochemical-Society. 24:S446-S446. (Aug 1996).
  • Hughes AD; Betteridge L; Clunn G; Patel M; Schachter M; Wijetunge S. Signals evoked by angiotensin II in vascular smooth muscle cells. International Workshop on Adrenal Glands, Vascular System and Hypertension, 20 Apr 1995 - 22 Apr 1995. 89-102. SOCIETY ENDOCRINOLOGY (1 Jan 1996). Author weblink.
  • Pickkers P; Russel FGM; Hughes AD; Thien T; Smits P. Hydrochlorothiazide exerts no direct vasoactivity in the human forearm. 7th European Meeting on Hypertension, 9 Jun 1995 - 12 Jun 1995. 13:1833-1836. RAPID SCIENCE PUBLISHERS (1 Dec 1995). Author weblink.
  • Clunn GF; Refson JS; Schachter M; Hughes AD. Different effects of platelet derived growth factor isoforms on DNA synthesis and migration in human vascular smooth muscle cells. 655th Meeting of the Biochemical-Society. 23:S608-S608. (Nov 1995).
  • CLUNN GF; SCHACHTER M; HUGHES AD. Contrasting mechanisms of intracellular calcium ([Ca2+](i)) elevation by angiotensin II (AII) and platelet derived growth Factor-BB (PDGF-BB) in human vascular smooth muscle cells (VSMCs). 653rd Meeting of the Biochemical-Society-of-London. 23:S170-S170. (May 1995).
  • HUGHES AD; SCHACHTER M. ALF4- INHIBITS INFLUX OF CA2+ INTO VASCULAR SMOOTH-MUSCLE CELLS. 653rd Meeting of the Biochemical-Society-of-London, 13 Sep 1994 - 16 Sep 1994. 23:S171-S171. PORTLAND PRESS (1 May 1995). Author weblink.
  • HUGHES AD; SCHACHTER M. AlF4- inhibits influx of Ca2+ into vascular smooth muscle cells. 653rd Meeting of the Biochemical-Society-of-London. 23:S171-S171. (May 1995).
  • CLUNN GF; SCHACHTER M; HUGHES AD. CONTRASTING MECHANISMS OF INTRACELLULAR CALCIUM ([CA2+](I)) ELEVATION BY ANGIOTENSIN-II (AII) AND PLATELET-DERIVED GROWTH FACTOR-BB (PDGF-BB) IN HUMAN VASCULAR SMOOTH-MUSCLE CELLS (VSMCS). 653rd Meeting of the Biochemical-Society-of-London, 13 Sep 1994 - 16 Sep 1994. 23:S170-S170. PORTLAND PRESS (1 May 1995). Author weblink.
  • HUGHES AD; CLUNN GF; SCHACHTER M. A COMPARISON OF CALCIUM-CHANNEL CURRENTS IN VASCULAR SMOOTH-MUSCLE CELLS FROM WATANABE HEREDITARY HYPERCHOLESTEROLEMIC AND NEW-ZEALAND WHITE-RABBITS. 650th Meeting of the Biochemical-Society. 22:S361-S361. (Aug 1994).
  • HUGHES AD; CLUNN GF; SCHACHTER M. LOW-DENSITY-LIPOPROTEIN AND CALCIUM HOMEOSTASIS IN HUMAN VASCULAR SMOOTH-MUSCLE CELLS. 649th Meeting of the Biochemical-Society, 19 Dec 1993 - 21 Dec 1993. 22:S145-S145. PORTLAND PRESS (1 May 1994). Author weblink.
  • Martinez-Perez ME; Hughes AD; Thom SA; Parker KH. Improvement of a retinal blood vessel segmentation method using the Insight Segmentation and Registration Toolkit (ITK). 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society., Aug 2007 - Aug 2007. 892-895.
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