Dr Andrew E Messer

Publications


Journals

  • Memo M; Messer AE; Marston SB. (22 Nov 2011). Mutations in Thin Filament Proteins That Cause Familial Dilated Cardiomyopathy Uncouple Troponin I Phosphorylation From Changes in Myofibrillar Ca2+Sensitivity. CIRCULATION. 124. Author weblink.
  • Bayliss C; Marston SB; Messer AE. (22 Nov 2011). Troponin I Phosphorylation is Uncoupled From Myofibrillar Ca2+-sensitivity in Septal Myectomy Samples From Hocm Patients Due to an Abnormality in Troponin T. CIRCULATION. 124. Author weblink.
  • Copeland O; Sadayappan S; Messer AE; Steinen GJ; van der Velden J; Marston SB. (Dec 2010). Analysis of cardiac myosin binding protein-C phosphorylation in human heart muscle. J Mol Cell Cardiol. 49:1003-1011. DOI.
  • Copeland O; Nowak KJ; Laing NG; Ravenscroft G; Messer AE; Bayliss CR; Marston SB. (Sep 2010). Investigation of changes in skeletal muscle alpha-actin expression in normal and pathological human and mouse hearts. J Muscle Res Cell Motil. 31:207-214. DOI.
  • Messer AE; Gallon CE; McKenna WJ; Dos Remedios CG; Marston SB. (1 Dec 2009). The use of phosphate-affinity SDS-PAGE to measure the cardiac troponin I phosphorylation site distribution in human heart muscle. PROTEOMICS CLINICAL APPLICATIONS. 3:1371-1382. Author weblink DOI.
  • Dyer EC; Jacques AM; Hoskins AC; Ward DG; Gallon CE; Messer AE; Kaski JP; Burch M; et alKentish JC; Marston SB. (1 Sep 2009). Functional Analysis of a Unique Troponin C Mutation, GLY159ASP, that Causes Familial Dilated Cardiomyopathy, Studied in Explanted Heart Muscle. CIRCULATION-HEART FAILURE. 2:456-U101. Author weblink DOI.
  • Hamdani N; de Waard M; Messer AE; Boontje NM; Kooij V; van Dijk S; Versteilen A; Lamberts R; et alMerkus D; dos Remedios C; Duncker DJ; Borbely A; Papp Z; Paulus W; Stienen GJM; Marston SB; van der Velden J. (1 Dec 2008). Myofilament dysfunction in cardiac disease from mice to men. JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY. 29:189-201. DOI.
  • Jacques AM; Copeland O; Messer AE; Gallon CE; King K; McKenna WJ; Tsang VT; Marston SB. (1 Aug 2008). Myosin binding protein C phosphorylation in normal, hypertrophic and failing human heart muscle. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 45:209-216. Author weblink DOI.
  • Jacques AM; Briceno N; Messer AE; Gallon CE; Jalilzadeh S; Garcia E; Kikonda-Kanda G; Goddard J; et alHarding SE; Watkins H; Esteban MT; Tsang VT; McKenna WJ; Marston SB. (1 Aug 2008). The molecular phenotype of human cardiac myosin associated with hypertrophic obstructive cardiomyopathy. Cardiovasc Res. 79:481-491. DOI.
  • Messer AE; Jacques AM; Marston SB. (Jan 2007). Troponin phosphorylation and regulatory function in human heart muscle: dephosphorylation of Ser23/24 on troponin I could account for the contractile defect in end-stage heart failure. J Mol Cell Cardiol. 42:247-259. DOI.

Conferences

  • Memo M; Messer AE; Marston SB. Mutations in thin filament proteins that cause familial dilated cardiomyopathy uncouple troponin I phosphorylation from changes in myofibrillar Ca2+ sensitivity. 2nd Congress of the European-Society-of-Cardiology Council on Basic Cardiovascular Science - Frontiers in Cardiovascular Biology, 30 Mar 2012 - 1 Apr 2012. 93:S107-S108. OXFORD UNIV PRESS (15 Mar 2012). Author weblink.
  • Bayliss CR; Messer AE; Leung M-C; Ward D; Van Der Velden J; Poggesi C; Redwood CS; Marston S. Functional investigation of troponin with the homozygous HCM mutation, TNNT2 K280N, obtained from an explanted heart. 2nd Congress of the European-Society-of-Cardiology Council on Basic Cardiovascular Science - Frontiers in Cardiovascular Biology, 30 Mar 2012 - 1 Apr 2012. 93:S107-S107. OXFORD UNIV PRESS (15 Mar 2012). Author weblink.
  • Messer AE; Marston S; Memo M; Leung M-C; Bayliss CR. Does uncoupling of troponin I phosphorylation from changes in myofibrillar Ca2+-sensitivity play a role in the pathogenesis of cardiomyopathy?. 2nd Congress of the European-Society-of-Cardiology Council on Basic Cardiovascular Science - Frontiers in Cardiovascular Biology, 30 Mar 2012 - 1 Apr 2012. 93:S107-S107. OXFORD UNIV PRESS (15 Mar 2012). Author weblink.
  • Leung MC; Messer AE; Copeland O; Marston SB. O-GlcNAcylation in the long isoform of ZASP. 2nd Congress of the European-Society-of-Cardiology Council on Basic Cardiovascular Science - Frontiers in Cardiovascular Biology, 30 Mar 2012 - 1 Apr 2012. 93:S68-S68. OXFORD UNIV PRESS (15 Mar 2012). Author weblink.
  • Messer AE; Copeland O; Leung M; Marston SB. Analysis of sarcomeric protein phosphorylation in situ using phosphate affinity SDS-PAGE. Conference on Frontiers in Cardiovascular Biology, 16 Jul 2010 - 19 Jul 2010. 87:S64-S65. OXFORD UNIV PRESS (1 Jul 2010). Author weblink.
  • Marston SB; Messer AE; Gallon CE; Sancho-Sollis R; Walker JW. DETERMINATION OF TROPONIN I PHOSPHORYLATION SITES IN HUMAN HEART MUSCLE. Conference on Myocardial Energetics and Redox in Health and Disease, 7 Sep 2009 - 8 Sep 2009. 96. B M J PUBLISHING GROUP (1 Feb 2010). DOI.
  • Bayliss CR; Messer AE; Copeland O; Gallon CE; Marston SB. THIN FILAMENTS RECONSTITUTED WITH TROPONIN EXTRACTED FROM PATIENTS WITH HYPERTROPHIC OBSTRUCTIVE CARDIOMYOPATHY ARE FUNCTIONALLY ABNORMAL. Conference on Myocardial Energetics and Redox in Health and Disease, 7 Sep 2009 - 8 Sep 2009. 96. B M J PUBLISHING GROUP (1 Feb 2010). DOI.
  • Memo M; Messer AE; Song W; Marston SB. A NEW MOLECULAR MECHANISM FOR FAMILIAL DILATED CARDIOMYOPATHY BASED ON STUDIES WITH INTACT MUTANT TRANSGENIC MOUSE AND HUMAN EXPLANTED HEART MUSCLE. Conference on Myocardial Energetics and Redox in Health and Disease, 7 Sep 2009 - 8 Sep 2009. 96. B M J PUBLISHING GROUP (1 Feb 2010). DOI.
  • Marston SB; Dyer EC; Jacques AM; Messer AE; Wells D; Song W. A New Molecular Mechanism for Familial Dilated Cardiomyopathy Based on Studies with Intact Mutant Transgenic Mouse and Human Explanted Heart Muscle. 63rd Annual Meeting of the Society-of-General-Physiologists, 9 Sep 2009 - 13 Sep 2009. 134:13A-14A. ROCKEFELLER UNIV PRESS (1 Jul 2009). Author weblink.
  • Garcia EA; Kanda GK; Lyon A; Gallon CE; Messer AE; O'Gara P; Marston SB; Harding SE. Tonic support of contraction involving the PI3 kinase pathway in ventricular myocytes from failing human heart. 28th Annual Meeting of the European Section of the International-Society-for-Heart-Research. 44:752-753. (Apr 2008).
  • Gallon C; Jacques A; Messer A; Tsang V; McKenna W; Marston S. Altered function and post-translational modification of contractile proteins in myectomy samples from HOCM patients. 19th World Congress of the ISHR. 42:S167-S167. (Jun 2007).
  • Messer AE; Jacques AM; Marston SB. Dephosphorylation of Ser23/24 on Troponin I could account for the contractile defect in end-stage failing human heart. 28th Annual International-Society-for-Heart-Research North American Section Meeting. 40:941-941. (Jun 2006).
  • Messer AE; Jacques A; Marston SB. Cardiac troponin I dephosphorylation in human heart failure: The role of phosphatase activation. 79th Annual Scientific Session of the American-Heart-Association. 114:64-65. (31 Oct 2006).
  • Jacques AM; Messer AE; Gallon CE; Tsang V; McKenna WJ; Marston SB. A comparison between TnT, TnI, MyBP-C and MLC-2 phosphorylation in tissue from septal myectomies of hypertrophic obstructive cardiomyopathy patients and donor hearts. 51st Annual Meeting of the Biophysical-Society. 541A-541A. (Jan 2007).
  • Messer AE; Jacques AM; Marston SB. Measurement of troponin phosphatase activities in normal and failing human heart muscle. 51st Annual Meeting of the Biophysical-Society, 3 Mar 2007 - 7 Mar 2007. 630A-630A. BIOPHYSICAL SOCIETY (1 Jan 2007). Author weblink.
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