Dr Andrew R Clark

Publications


Journals

  • Turpeinen T; Nieminen R; Taimi V; Heittola T; Sareila O; Clark AR; Moilanen E; Korhonen R. (1 Jan 2011). Dual Specificity Phosphatase 1 Regulates Human Inducible Nitric Oxide Synthase Expression by p38MAP Kinase. MEDIATORS OF INFLAMMATION. . DOI.
  • Vattakuzhi Y; Abraham SM; Freidin A; Clark AR; Horwood NJ. (24 Jan 2012). Dual Specificity Phosphatase 1 null mice exhibit spontaneous osteolytic disease and enhanced inflammatory osteolysis in experimental arthritis. Arthritis Rheum. DOI.
  • Clark AR; Belvisi MG. (Apr 2012). Maps and legends: the quest for dissociated ligands of the glucocorticoid receptor. Pharmacol Ther. 134:54-67. DOI.
  • Joanny E; Ding Q; Gong L; Kong P; Saklatvala J; Clark AR. (Feb 2012). Anti-inflammatory effects of selective glucocorticoid receptor modulators are partially dependent on up-regulation of dual specificity phosphatase 1. Br J Pharmacol. 165:1124-1136. DOI.
  • Li F; Zhang M; Hussain F; Triantaphyllopoulos K; Clark AR; Bhavsar PK; Zhou X; Chung KF. (Apr 2011). Inhibition of p38 MAPK-dependent bronchial contraction after ozone by corticosteroids. Eur Respir J. 37:933-942. DOI.
  • Nieminen R; Korhonen R; Moilanen T; Clark AR; Moilanen E. (1 Jan 2010). MAP KINASE PHOSPHATASE-1 AS A NOVEL TARGET OF GOLD-CONTAINING DMARDS. SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 39:443-443. Author weblink.
  • Ralph JA; Ahmed AU; Santos LL; Clark AR; McMorrow J; Murphy EP; Morand EF. (Nov 2010). Identification of NURR1 as a mediator of MIF signaling during chronic arthritis: effects on glucocorticoid-induced MKP1. Am J Pathol. 177:2366-2378. DOI.
  • Smallie T; Ricchetti G; Horwood NJ; Feldmann M; Clark AR; Williams LM. (27 Sep 2010). IL-10 inhibits transcription elongation of the human TNF gene in primary macrophages. J Exp Med. 207:2081-2088. DOI.
  • Kristiansen M; Hughes R; Patel P; Jacques TS; Clark AR; Ham J. (11 Aug 2010). Mkp1 is a c-Jun target gene that antagonizes JNK-dependent apoptosis in sympathetic neurons. J Neurosci. 30:10820-10832. DOI.
  • Nieminen R; Korhonen R; Moilanen T; Clark AR; Moilanen E. (1 Jun 2010). Aurothiomalate Inhibits Cyclooxygenase 2, Matrix Metalloproteinase 3, and Interleukin-6 Expression in Chondrocytes by Increasing MAPK Phosphatase 1 Expression and Decreasing p38 Phosphorylation. ARTHRITIS AND RHEUMATISM. 62:1650-1659. DOI.
  • Marchese FP; Aubareda A; Tudor C; Saklatvala J; Clark AR; Dean JL. (Jul 2001). MAPKAP kinase 2 blocks tristetraprolin-directed mRNA decay by inhibiting CAF1 deadenylase recruitment. J Biol Chem. Epub ahead of print.
  • Chaudhury H; Zakkar M; Boyle J; Cuhlmann S; van der Heiden K; Luong LEA; Davis J; Platt A; et alMason JC; Krams R; Haskard DO; Clark AR; Evans PC. (Mar 2010). c-Jun N-terminal kinase primes endothelial cells at atheroprone sites for apoptosis. Arterioscler Thromb Vasc Biol. 30:546-553. DOI.
  • Tchen CR; Martins JR; Paktiawal N; Perelli R; Saklatvala J; Clark AR. (22 Jan 2010). Glucocorticoid regulation of mouse and human dual specificity phosphatase 1 (DUSP1) genes: unusual cis-acting elements and unexpected evolutionary divergence. J Biol Chem. 285:2642-2652. DOI.
  • Clark AR; Dean JL; Saklatvala J. (Nov 2009). The p38 MAPK pathway mediates both antiinflammatory and proinflammatory processes: comment on the article by Damjanov and the editorial by Genovese. Arthritis Rheum. 60:3513-3514. DOI.
  • Tudor C; Marchese FP; Hitti E; Aubareda A; Rawlinson L; Gaestel M; Blackshear PJ; Clark AR; et alSaklatvala J; Dean JLE. (18 Jun 2009). The p38 MAPK pathway inhibits tristetraprolin-directed decay of interleukin-10 and pro-inflammatory mediator mRNAs in murine macrophages. FEBS LETTERS. 583:1933-1938. Author weblink DOI.
  • Zakkar M; Chaudhury H; Sandvik G; Enesa K; Luong LA; Cuhlmann S; Mason JC; Krams R; et alClark AR; Haskard DO; Evans PC. (26 Sep 2008). Increased endothelial mitogen-activated protein kinase phosphatase-1 expression suppresses proinflammatory activation at sites that are resistant to atherosclerosis. CIRCULATION RESEARCH. 103:726-732. Author weblink DOI.
  • Clark AR; Martins JR; Tchen CR. (19 Sep 2008). Role of dual specificity phosphatases in biological responses to glucocorticoids. J Biol Chem. 283:25765-25769. DOI.
  • Clark AR. (15 Sep 2007). Anti-inflammatory functions of glucocorticoid-induced genes. MOLECULAR AND CELLULAR ENDOCRINOLOGY. 275:79-97. Author weblink DOI.
  • Bell SE; Sanchez MJ; Spasic-Boskovic O; Santalucia T; Gambardella L; Burton GJ; Murphy JJ; Norton JD; et alClark AR; Turner M. (1 Nov 2006). The RNA binding protein Zfp36l1 is required for normal vascularisation and post-transcriptionally regulates VEGF expressiono. DEVELOPMENTAL DYNAMICS. 235:3144-3155. Author weblink DOI.
  • Abraham SM; Clark AR. (Dec 2006). Dual-specificity phosphatase 1: a critical regulator of innate immune responses. Biochem Soc Trans. 34:1018-1023. DOI.
  • Abraham SM; Lawrence T; Kleiman A; Warden P; Medghalchi M; Tuckermann J; Saklatvala J; Clark AR. (7 Aug 2006). Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1. J Exp Med. 203:1883-1889. DOI.
  • Hitti E; Iakovleva T; Brook M; Deppenmeier S; Gruber AD; Radzioch D; Clark AR; Blackshear PJ; et alKotlyarov A; Gaestel M. (1 Mar 2006). Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine/uridine-rich element. MOLECULAR AND CELLULAR BIOLOGY. 26:2399-2407. Author weblink DOI.
  • Brook M; Tchen CR; Santalucia T; McIlrath J; Arthur JS; Saklatvala J; Clark AR. (Mar 2006). Posttranslational regulation of tristetraprolin subcellular localization and protein stability by p38 mitogen-activated protein kinase and extracellular signal-regulated kinase pathways. Mol Cell Biol. 26:2408-2418. DOI.
  • Dean JLE; Wait R; Mahtani KR; Sully G; Clark AR; Saklatvala J. (1 Apr 2005). The 3' untranslated region of tumor necrosis factor alpha mRNA is a target of the mRNA-stabilizing factor HuR (vol 21, pg 721, 2001). MOLECULAR AND CELLULAR BIOLOGY. 25:3400-3400. Author weblink DOI.
  • Mavropoulos A; Sully G; Cope AP; Clark AR. (1 Jan 2005). Stabilization of IFN-gamma mRNA by MAPK p38 in IL-12- and IL-18-stimulated human NK cells. Blood. 105:282-288. DOI.
  • Dean JL; Sully G; Clark AR; Saklatvala J. (Oct 2004). The involvement of AU-rich element-binding proteins in p38 mitogen-activated protein kinase pathway-mediated mRNA stabilisation. Cell Signal. 16:1113-1121. DOI.
  • Tchen CR; Brook M; Saklatvala J; Clark AR. (30 Jul 2004). The stability of tristetraprolin mRNA is regulated by mitogen-activated protein kinase p38 and by tristetraprolin itself. J Biol Chem. 279:32393-32400. DOI.
  • Sully G; Dean JL; Wait R; Rawlinson L; Santalucia T; Saklatvala J; Clark AR. (1 Feb 2004). Structural and functional dissection of a conserved destabilizing element of cyclo-oxygenase-2 mRNA: evidence against the involvement of AUF-1 [AU-rich element/poly(U)-binding/degradation factor-1], AUF-2, tristetraprolin, HuR (Hu antigen R) or FBP1 (far-upstream-sequence-element-binding protein 1). Biochem J. 377:629-639. DOI.
  • Clark AR; Lasa M. (Aug 2003). Crosstalk between glucocorticoids and mitogen-activated protein kinase signalling pathways. Curr Opin Pharmacol. 3:404-411.
  • Clark AR; Dean JL; Saklatvala J. (3 Jul 2003). Post-transcriptional regulation of gene expression by mitogen-activated protein kinase p38. FEBS Lett. 546:37-44.
  • Clark AR. (Jul 2003). MAP kinase phosphatase 1: a novel mediator of biological effects of glucocorticoids?. J Endocrinol. 178:5-12.
  • Lasa M; Abraham SM; Boucheron C; Saklatvala J; Clark AR. (Nov 2002). Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38. Mol Cell Biol. 22:7802-7811.
  • Dean JL; Sully G; Wait R; Rawlinson L; Clark AR; Saklatvala J. (15 Sep 2002). Identification of a novel AU-rich-element-binding protein which is related to AUF1. Biochem J. 366:709-719. DOI.
  • Mahtani KR; Brook M; Dean JL; Sully G; Saklatvala J; Clark AR. (Oct 2001). Mitogen-activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stability. Mol Cell Biol. 21:6461-6469.
  • Lasa M; Brook M; Saklatvala J; Clark AR. (Feb 2001). Dexamethasone destabilizes cyclooxygenase 2 mRNA by inhibiting mitogen-activated protein kinase p38. Mol Cell Biol. 21:771-780. DOI.
  • Dean JL; Wait R; Mahtani KR; Sully G; Clark AR; Saklatvala J. (Feb 2001). The 3' untranslated region of tumor necrosis factor alpha mRNA is a target of the mRNA-stabilizing factor HuR. Mol Cell Biol. 21:721-730. DOI.
  • Brook M; Sully G; Clark AR; Saklatvala J. (13 Oct 2000). Regulation of tumour necrosis factor alpha mRNA stability by the mitogen-activated protein kinase p38 signalling cascade. FEBS Lett. 483:57-61.
  • Lasa M; Mahtani KR; Finch A; Brewer G; Saklatvala J; Clark AR. (Jun 2000). Regulation of cyclooxygenase 2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascade. Mol Cell Biol. 20:4265-4274.
  • Dean JL; Brook M; Clark AR; Saklatvala J. (1 Jan 1999). p38 mitogen-activated protein kinase regulates cyclooxygenase-2 mRNA stability and transcription in lipopolysaccharide-treated human monocytes. J Biol Chem. 274:264-269.
  • Ridley SH; Dean JL; Sarsfield SJ; Brook M; Clark AR; Saklatvala J. (13 Nov 1998). A p38 MAP kinase inhibitor regulates stability of interleukin-1-induced cyclooxygenase-2 mRNA. FEBS Lett. 439:75-80.

Conferences

  • Korhonen R; Nieminen R; Turpeinen T; Taimi V; Goulas A; Clark AR; Moilanen E. Regulatory and Anti-Inflammatory Effects of MAP Kinase Phosphatase-1 in Inflammation and Arthritis. 75th Annual Scientific Meeting of the American-College-of-Rheumatology/46th Annual Scientific Meeting of the Association-of-Rheumatology-Health-Professionals, 4 Nov 2011 - 9 Nov 2011. 63:S17-S17. WILEY-BLACKWELL (1 Oct 2011).
  • Zakkar M; Chaudhury H; Krams R; Mason JC; Clark AR; Haskard DO; Evans PC. Map kinase phosphatase-1 suppresses endothelial activation in regions of the arterial tree that are resistant to atherosclerosis. Spring Meeting of the British-Atherosclerosis-Society on Angiogenesis and Atherosclerosis. 199:465-465. (Aug 2008).
  • Tudor C; Hitti E; Blackshear PJ; Clark AR; Saklatvala J; Dean JLE. Identification of target mRNAs regulated by both p38 MAPK and tristetraprolin in murine macrophages. Annual Congress of the British-Society-of-Immunology. 120:16-16. (Mar 2007).
  • Khoury M; Apparailly F; Clark AR; Plence P; Noel D; Jorgensen C. Post-transcriptional regulation of proinflammatory cytokines in arthritis using gene delivery of AU-rich element binding factors. 25th European Workshop for Rheumatology Research, 24 Feb 2005 - 27 Feb 2005. 7:S28-S28. BIOMED CENTRAL LTD (1 Feb 2005). Author weblink DOI.
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