Contact details
Dr Brenda M Luken
Dr Brenda Luken is a postdoctoral research associate in the Haemostasis & Thrombosis group at the Department of Haematology and works together with Professor David Lane and Dr Jim Crawley. She obtained her MSc in Molecular and Cellular Biology from the VU University, Amsterdam, the Netherlands. She performed her PhD research at the Department of Plasma Proteins at Sanquin Research and obtained her PhD from the Faculty of Pharmaceutical Sciences, Utrecht University, the Netherlands in January 2006. After finishing her PhD project she continued to work at the same department for two years as a postdoctoral research associate. She joined the Haematology department in April 2007. Her current research focusses on structure/function relationships of proteins involved in thrombosis/haemostasis; including protein S, TFPI, VWF and ADAMTS13.Selected Publications
Journals
- Andersson HM; Siegerink B; Luken BM; Crawley JT; Algra A; Lane DA; Rosendaal FR. (22 Nov 2011). High VWF, low ADAMTS13 and oral contraceptives increase the risk of ischemic stroke and myocardial infarction in young women. Blood. DOI.
- Froehlich-Zahnd R; George JN; Vesely SK; Terrell DR; Aboulfatova K; Dong JF; Luken BM; Voorberg J; et alBudde U; Sulzer I; Lämmle B; Kremer Hovinga JA. (Feb 2012). Evidence for a role of anti-ADAMTS13 autoantibodies despite normal ADAMTS13 activity in recurrent thrombotic thrombocytopenic purpura. Haematologica. 97:297-303. DOI.
- Luken BM; Winn LY; Emsley J; Lane DA; Crawley JT. (10 Jun 2010). The importance of vicinal cysteines, C1669 and C1670, for von Willebrand factor A2 domain function. Blood. 115:4910-4913. DOI.
- Andersson HM; Arantes MJ; Crawley JT; Luken BM; Tran S; Dahlbäck B; Lane DA; Rezende SM. (10 Jun 2010). Activated protein C cofactor function of protein S: a critical role for Asp95 in the EGF1-like domain. Blood. 115:4878-4885. DOI.
- Pos W; Crawley JT; Fijnheer R; Voorberg J; Lane DA; Luken BM. (25 Feb 2010). An autoantibody epitope comprising residues R660, Y661, and Y665 in the ADAMTS13 spacer domain identifies a binding site for the A2 domain of VWF. Blood. 115:1640-1649. DOI.
- Pos W; Luken BM; Hovinga JAK; Turenhout EAM; Scheiflinger F; Dong JF; Fijnheer R; Voorberg J. (Mar 2009). VH1-69 germline encoded antibodies directed towards ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura. J THROMB HAEMOST. 7:421-428. DOI.
