Professor Bernard J Morley

Publications


Journals

  • Gabriel L; Morley BJ; Rogers NJ. (Sep 2009). The role of iNKT cells in the immunopathology of systemic lupus erythematosus. Ann N Y Acad Sci. 1173:435-441. Author weblink DOI.
  • Yoshinobu K; Baudino L; Santiago-Raber M-L; Morito N; Dunand-Sauthier I; Morley BJ; Evans LH; Izui S. (15 Jun 2009). Selective Up-Regulation of Intact, but Not Defective env RNAs of Endogenous Modified Polytropic Retrovirus by the Sgp3 Locus of Lupus-Prone Mice. JOURNAL OF IMMUNOLOGY. 182:8094-8103. Author weblink.
  • Rogers NJ; Lees MJ; Gabriel L; Maniati E; Rose SJ; Potter PK; Morley BJ. (15 Feb 2009). A defect in Marco expression contributes to systemic lupus erythematosus development via failure to clear apoptotic cells. J Immunol. 182:1982-1990. Author weblink DOI.
  • Baudino L; Yoshinobu K; Morito N; Kikuchi S; Fossati-Jimack L; Morley BJ; Vyse TJ; Hirose S; et alJorgensen TN; Tucker RM; Roark CL; Kotzin BL; Evans LH; Izui S. (15 Aug 2008). Dissection of genetic mechanisms governing the expression of serum retroviral gp70 implicated in murine lupus nephritis. JOURNAL OF IMMUNOLOGY. 181:2846-2854. Author weblink.
  • Maniati E; Potter P; Rogers NJ; Morley BJ. (1 Jan 2008). Control of apoptosis in autoimmunity. JOURNAL OF PATHOLOGY. 214:190-198. Author weblink DOI.
  • Rogers NJ; Gabriel L; Nunes CT; Rose SJ; Thiruudaian V; Boyle J; Morley BJ. (Dec 2007). Monocytosis in BXSB mice is due to epistasis between Yaa and the telomeric region of chromosome 1 but does not drive the disease process. Genes Immun. 8:619-627. Author weblink DOI.
  • Haywood ME; Gabriel L; Rose SJ; Rogers NJ; Izui S; Morley BJ. (15 Aug 2007). BXSB/long-lived is a recombinant inbred strain containing powerful disease suppressor loci. J Immunol. 179:2428-2434. Author weblink.
  • Deacon RMJ; Thomas CL; Rawlins JNP; Morley BJ. (16 May 2007). A comparison of the behavior of C57BL/6 and C57BL/10 mice. BEHAVIOURAL BRAIN RESEARCH. 179:239-247. Author weblink DOI.
  • Rankin J; Boyle JJ; Rose SJ; Gabriel L; Lewis M; Thiruudaian V; Rogers NJ; Izui S; et alMorley BJ. (1 Apr 2007). The Bxs6 locus of BXSB mice is sufficient for high-level expression of gp70 and the production of gp70 immune complexes. J Immunol. 178:4395-4401. Author weblink.
  • Haywood ME; Rose SJ; Horswell S; Lees MJ; Fu G; Walport MJ; Morley BJ. (Apr 2006). Overlapping BXSB congenic intervals, in combination with microarray gene expression, reveal novel lupus candidate genes. Genes Immun. 7:250-263. Author weblink DOI.
  • Rogers NJ; Nunes CT; Rose SJ; Morley BJ. (1 Dec 2005). Monocytosis in a murine model of SLE maps to the bottom of chromosome 1. IMMUNOLOGY. 116:10-10. Author weblink.
  • Choi P; Xanthaki D; Rose SJ; Haywood M; Reiser H; Morley BJ. (Jun 2005). Linkage analysis of the genetic determinants of T-cell IL-4 secretion, and identification of Flj20274 as a putative candidate gene. Genes Immun. 6:290-297. Author weblink DOI.
  • Haywood ME; Rogers NJ; Rose SJ; Boyle J; McDermott A; Rankin JM; Thiruudaian V; Lewis MR; et alFossati-Jimack L; Izui S; Walport MJ; Morley BJ. (1 Oct 2004). Dissection of BXSB lupus phenotype using mice congenic for chromosome 1 demonstrates that separate intervals direct different aspects of disease. J Immunol. 173:4277-4285. Author weblink.
  • Lee NJ; Rigby RJ; Gill H; Boyle JJ; Fossati-Jimack L; Morley BJ; Vyse TJ. (1 Oct 2004). Multiple loci are linked with anti-red blood cell antibody production in NZB mice - comparison with other phenotypes implies complex modes of action. CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 138:39-46. Author weblink DOI.
  • Rigby RJ; Rozzo SJ; Gill H; Fernandez-Hart T; Morley BJ; Izui S; Kotzin BL; Vyse TJ. (15 Apr 2004). A novel locus regulates both retroviral glycoprotein 70 and anti-glycoprotein 70 antibody production in New Zealand mice when crossed with BALB/c. J Immunol. 172:5078-5085. Author weblink.
  • Fu G; Haywood ME; Morley BJ. (15 Mar 2002). Representational difference analysis in a lupus-prone mouse strain results in the identification of an unstable region of the genome on chromosome 11. Nucleic Acids Res. 30:1394-1400. Author weblink.
  • Roberton CA; Morley BJ; Vyse TJ. (1 Oct 2001). Fine mapping genes for Fc gamma receptor II and III in systemic lupus erythematosus. AMERICAN JOURNAL OF HUMAN GENETICS. 69:568-568. Author weblink.
  • Haywood ME; Vyse TJ; McDermott A; Thompson EM; Ida A; Walport MJ; Izui S; Morley BJ. (1 Aug 2001). Autoantigen glycoprotein 70 expression is regulated by a single locus, which acts as a checkpoint for pathogenic anti-glycoprotein 70 autoantibody production and hence for the corresponding development of severe nephritis, in lupus-prone PXSB mice. J Immunol. 167:1728-1733. Author weblink.
  • Stocker CJ; Sugars KL; Yarwood H; Delikouras A; Lechler RI; Dorling A; Landis RC; Morley BJ; et alHaskard DO. (27 Aug 2000). Cloning of porcine intercellular adhesion molecule-1 and characterization of its induction on endothelial cells by cytokines. Transplantation. 70:579-586. Author weblink.
  • Maibaum MA; Haywood ME; Walport MJ; Morley BJ. (Apr 2000). Lupus susceptibility loci map within regions of BXSB derived from the SB/Le parental strain. Immunogenetics. 51:370-372. Author weblink.
  • Stocker CJ; Sugars KL; Harari OA; Landis RC; Morley BJ; Haskard DO. (15 Mar 2000). TNF-alpha, IL-4, and IFN-gamma regulate differential expression of P- and E-selectin expression by porcine aortic endothelial cells. J Immunol. 164:3309-3315. Author weblink.
  • Pritchard NR; Cutler AJ; Uribe S; Chadban SJ; Morley BJ; Smith KGC. (24 Feb 2000). Autoimmune-prone mice share a promoter haplotype associated with reduced expression and function of the Fc receptor Fc gamma RII. CURRENT BIOLOGY. 10:227-230. Author weblink DOI.
  • Haywood ME; Hogarth MB; Slingsby JH; Rose SJ; Allen PJ; Thompson EM; Maibaum MA; Chandler P; et alDavies KA; Simpson E; Walport MJ; Morley BJ. (Feb 2000). Identification of intervals on chromosomes 1, 3, and 13 linked to the development of lupus in BXSB mice. Arthritis Rheum. 43:349-355. Author weblink DOI.
  • Maibaum MA; Fu G; Haywood MEK; Uribe S; Rose SJ; Sim RB; Walport MJ; Morley BJ. (1 Oct 1999). Candidate gene analysis in the lupus-prone mouse strain, BXSB. AMERICAN JOURNAL OF HUMAN GENETICS. 65:A262-A262. Author weblink.
  • Haywood MEK; Hogarth MB; Slingsby JH; Rose SJ; Thompson EM; Maibaum MA; Walport MJ; Morley BJ. (1 Oct 1999). Genome-wide linkage analyses in the lupus-prone mouse strain, BXSB. AMERICAN JOURNAL OF HUMAN GENETICS. 65:A105-A105. Author weblink.
  • Hogarth MB; Slingsby JH; Allen PJ; Thompson EM; Chandler P; Davies KA; Simpson E; Morley BJ; et alWalport MJ. (15 Sep 1998). Multiple lupus susceptibility loci map to chromosome 1 in BXSB mice. J Immunol. 161:2753-2761. Author weblink.
  • Vaishnaw AK; Mitchell TJ; Rose SJ; Walport MJ; Morley BJ. (1 May 1998). Regulation of transcription of the TATA-less human complement component C4 gene. J Immunol. 160:4353-4360. Author weblink.
  • Morley BJ; Bartok I; Spath PJ; Vyse TJ; Schneider PM; Walport MJ. (1 Apr 1998). Molecular basis of hereditary factor I deficiency. MOLECULAR IMMUNOLOGY. 35:344-344. Author weblink DOI.
  • Mitchell TJ; Vaishnaw AK; Rose J; Walport MJ; Morley BJ. (1 Apr 1998). Transcriptional regulation of the human C4 gene. MOLECULAR IMMUNOLOGY. 35:344-344. Author weblink DOI.
  • Walport MJ; Davies KA; Morley BJ; Botto M. (5 Apr 1997). Complement deficiency and autoimmunity. Ann N Y Acad Sci. 815:267-281. Author weblink.
  • Slingsby JH; Hogarth MB; Walport MJ; Morley BJ. (1997). Polymorphism in the Ly-17 alloantigenic system of the mouse FcgRII gene. Immunogenetics. 46:361-362. Author weblink.
  • Mitchell TJ; Vaishnaw AK; Rose SJ; Walport MJ; Morley BJ. (1 Nov 1996). Tissue specific transcriptional control of the human complement C4 gene is directed by the first 126bp of the promoter. IMMUNOLOGY. 89:A3-A3. Author weblink.
  • Topaloglu R; Bakkaloglu A; Slingsby JH; Mihatsch MJ; Pascual M; Norsworthy P; Morley BJ; Saatci U; et alSchifferli JA; Walport MJ. (1 Aug 1996). Molecular basis of hereditary C1q deficiency associated with SLE and IgA nephropathy in a Turkish family. KIDNEY INTERNATIONAL. 50:635-642. Author weblink DOI.
  • Mitchell TJ; Naughton M; Norsworthy P; Davies KA; Walport MJ; Morley BJ. (1 Jun 1996). IFN-gamma up-regulates expression of the complement components C3 and C4 by stabilization of mRNA. J Immunol. 156:4429-4434. Author weblink.
  • Hogarth MB; Norsworthy PJ; Allen PJ; Trinder PKE; Loos M; Morley BJ; Walport MJ; Davies KA. (1 May 1996). Autoantibodies to the collagenous region of C1q occur in three strains of lupus-prone mice. CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 104:241-246. Author weblink DOI.
  • Slingsby JH; Norsworthy P; Pearce G; Vaishnaw AK; Issler H; Morley BJ; Walport MJ. (Apr 1996). Homozygous hereditary C1q deficiency and systemic lupus erythematosus. A new family and the molecular basis of C1q deficiency in three families. Arthritis Rheum. 39:663-670. Author weblink.
  • Slingsby JH; Dyson PJ; Morley BJ; Walport MJ; Simpson E. (Apr 1996). Localization of mtv44 to the centromeric region of mouse chromosome 11. Mamm Genome. 7:319-320. Author weblink.
  • Vyse TJ; Morley BJ; Bartok I; Theodoridis EL; Davies KA; Webster AD; Walport MJ. (15 Feb 1996). The molecular basis of hereditary complement factor I deficiency. J Clin Invest. 97:925-933. Author weblink DOI.
  • Slingsby JH; Hogarth MB; Simpson E; Walport MJ; Morley BJ. (1996). New microsatellite polymorphisms identified between C57BL/6, C57BL/10, and C57BL/KsJ inbred mouse strains. Immunogenetics. 43:72-75. Author weblink.
  • Petry F; McClive PJ; Botto M; Morley BJ; Morahan G; Loos M. (1 Jan 1996). The mouse C1q genes are clustered on chromosome 4 and show conservation of gene organization. IMMUNOGENETICS. 43:370-376. Author weblink DOI.
  • SLINGSBY JH; PEARCE GJ; NORSWORTHY PJ; DAVIES KA; ISSLER H; MORLEY BJ; WALPORT MJ. (1 Sep 1995). MOLECULAR-BASIS OF COMPLETE FUNCTIONAL C1Q DEFICIENCY IN 3 PATIENTS. ARTHRITIS AND RHEUMATISM. 38:184-184. Author weblink.
  • Vaishnaw AK; Hargreaves R; Campbell RD; Morley BJ; Walport MJ. (1995). DNase I hypersensitivity mapping and promoter polymorphism analysis of human C4. Immunogenetics. 41:354-358. Author weblink.
  • Vyse TJ; Bates GP; Walport MJ; Morley BJ. (1 Nov 1994). The organization of the human complement factor I gene (IF): a member of the serine protease gene family. Genomics. 24:90-98. Author weblink DOI.
  • Vyse TJ; Späth PJ; Davies KA; Morley BJ; Philippe P; Athanassiou P; Giles CM; Walport MJ. (Jul 1994). Hereditary complement factor I deficiency. QJM. 87:385-401. Author weblink.
  • Botto M; Fong KY; So AK; Barlow R; Routier R; Morley BJ; Walport MJ. (1 Jun 1992). Homozygous hereditary C3 deficiency due to a partial gene deletion. Proc Natl Acad Sci U S A. 89:4957-4961. Author weblink.
  • HOHLER T; BOTTO M; ROUTIER R; MORLEY BJ; WALPORT MJ. (1 Jan 1992). A SIMPLE METHOD FOR IDENTIFYING COMPLEMENT COMPONENT C3 POLYMORPHISMS. BRITISH JOURNAL OF RHEUMATOLOGY. 31:10-10. Author weblink.

Books

  • Morley, B J. Morley BJ (ed); Walport MJ (ed). The Complement Factsbook. Academic Press (2000).

Chapters in books

  • Morley, B J. Factor I. In The Complement Factsbook. 83-86. Morley (ed); B J (ed); Walport MJ (ed). Academic Press (2000).
  • Vyse, T J; Morley, B J. The analysis of genetic susceptibility. In HLA in health and disease. 2nd:107-128. Lechler R (ed); Warrens A (ed). Academic press (2000).

Conferences

  • Gabriel L; Morley BJ; Rogers NJ; Shoenfeld Y; Gershwin ME. The Role of iNKT Cells in the Immunopathology of Systemic Lupus Erythematosus. 6th International Congress on Autoimmunity, 10 Sep 2008 - 14 Sep 2008. 1173:435-441. BLACKWELL PUBLISHING (1 Jan 2009). Author weblink DOI.
  • Maniati E; Aw D; Palmer DB; Morley BJ; Rogers NJ. Alterations of the thymic environment in murine models of SLE. Annual Congress of the British-Society-of-Immunology, 17 Nov 2008 - 21 Nov 2008. 125:113-113. WILEY-BLACKWELL PUBLISHING, INC (1 Dec 2008). Author weblink.
  • Gabriel L; Mniati E; Rose SJ; Morley BJ; Rogers NJ. Characterisation of T helper profile in a murine model of SLE. Annual Congress of the British-Society-of-Immunology, 17 Nov 2008 - 21 Nov 2008. 125:96-96. WILEY-BLACKWELL PUBLISHING, INC (1 Dec 2008). Author weblink.
  • Gabriel L; Maniati E; Morley BJ; Rogers NJ. The role of NKT cells in the immunopathology of systemic lupus erythematosus. Annual Congress of the British-Society-of-Immunology, 17 Nov 2008 - 21 Nov 2008. 125:111-111. WILEY-BLACKWELL PUBLISHING, INC (1 Dec 2008). Author weblink.
  • Maniati E; Gomes MJ; Gabriel L; Morley BJ; Rogers NJ. The role of toll-like receptors in the BXSB model of SLE. Annual Congress of the British-Society-of-Immunology, 17 Nov 2008 - 21 Nov 2008. 125:112-113. WILEY-BLACKWELL PUBLISHING, INC (1 Dec 2008). Author weblink.
  • Gabriel L; Haywood MEK; Rose SJ; Rogers NJ; Izui S; Morley BJ. BXSB/long-lived is a recombinant inbred strain containing powerful disease suppressor loci. Annual Congress of the British-Society-of-Immunology, 20 Feb 2007 - 23 Feb 2007. 120:72-72. BLACKWELL PUBLISHING (1 Mar 2007). Author weblink.
  • Maniati E; Rogers NJ; Morley BJ. Lymphoid tissue distribution of DC subtypes in a murine model of SLE. Annual Congress of the British-Society-of-Immunology, 20 Feb 2007 - 23 Feb 2007. 120:73-73. BLACKWELL PUBLISHING (1 Mar 2007). Author weblink.
  • Rogers NJ; Gabriel L; Nunes CT; Rose J; Morley BJ. The role of CD4 T cells in the loss of tolerance in a murine model of SLE. Joint Meeting of the British-Society-for-Rheumatology/Deutsche-Gesellschaft-fur-Rheumatologie and Spring Meeting of the British-Health-Professionals-in-Rheumatology. 44:I136-I136. (Mar 2005).
  • Haywood MEK; Rose SJ; Rankin JM; Izui S; Rogers NJ; Morley BJ. The Y-linked autoimmune accelerator (YAA) gene is sufficient to break immunological tolerance. Joint Meeting of the British-Society-for-Rheumatology/Deutsche-Gesellschaft-fur-Rheumatologie and Spring Meeting of the British-Health-Professionals-in-Rheumatology, 19 Apr 2005 - 22 Apr 2005. 44:I135-I135. OXFORD UNIV PRESS (1 Mar 2005). Author weblink.
  • Rigby RJ; Horswell S; Haywood M; Shoulders C; Morley BJ; Vyse TJ. Differential transcript profiling identifies candidate genes in the New Zealand model of systemic lupus erythematosus, including the B-cell transcription factor, Bach2. 5th Annual Meeting of the Federation-of-Clinical-Immunology-Society. 115:S18-S19. (Jan 2005).
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