Professor Charles Coutelle

Publications


Journals

  • Argyros O; Wong SP; Fedonidis C; Tolmachov O; Waddington SN; Howe SJ; Niceta M; Coutelle C; et alHarbottle RP. (Feb 2011). Development of S/MAR minicircles for enhanced and persistent transgene expression in the mouse liver. Journal of molecular medicine (Berlin, Germany). 89(5):515-529. Publisher weblink DOI.
  • Bigger BW; Liao AY; Sergijenko A; Coutelle C. (Nov 2011). Trial and error: how the unclonable human mitochondrial genome was cloned in yeast. Pharm Res. 28:2863-2870. DOI.
  • Conese M; Ascenzioni F; Boyd AC; Coutelle C; De Fino I; De Smedt S; Rejman J; Rosenecker J; et alSchindelhauer D; Scholte BJ. (Jun 2011). Gene and cell therapy for cystic fibrosis: from bench to bedside. J Cyst Fibros. 10 Suppl 2:S114-S128. DOI.
  • Rahim AA; Wong AM; Buckley SM; Chan JK; David AL; Cooper JD; Coutelle C; Peebles DM; et alWaddington SN. (Dec 2010). In utero gene transfer to the mouse nervous system. Biochem Soc Trans. 38:1489-1493. DOI.
  • Al-Allaf FA; Coutelle C; Waddington SN; David AL; Harbottle R; Themis M. (2010). LDLR-Gene therapy for familial hypercholesterolaemia: problems, progress, and perspectives. Int Arch Med. 3:36. DOI.
  • Wong SP; Argyros O; Coutelle C; Harbottle RP. (Jan 2011). Non-viral S/MAR vectors replicate episomally in vivo when provided with a selective advantage. Gene Ther. 18:82-87. DOI.
  • David AL; Abi-Nader KN; Weisz B; Shaw SW; Themis M; Cook T; Coutelle C; Rodeck CH; et alPeebles DM. (Mar 2010). Ultrasonographic development of the fetal sheep stomach and evaluation of early gestation ultrasound-guided in utero intragastric injection. Taiwan J Obstet Gynecol. 49:23-29. DOI.
  • Coutelle C. (25 Jun 2009). From mould to man Edward Lewis Tatum’s vision of the future of medicine. Cellular Therapy and Transplantation (CTT), Vol. 1, No. 4, 2009. 1. DOI.
  • Wong SP; Argyros O; Coutelle C; Harbottle RP. (Aug 2009). Strategies for the episomal modification of cells. Curr Opin Mol Ther. 11:433-441.
  • Buckley SM; Howe SJ; Rahim AA; Buning H; McIntosh J; Wong SP; Baker AH; Nathwani A; et alThrasher AJ; Coutelle C; McKay TR; Waddington SN. (Oct 2008). Luciferin detection after intranasal vector delivery is improved by intranasal rather than intraperitoneal luciferin administration. Hum Gene Ther. 19:1050-1056. DOI.
  • Buckley SM; Howe SJ; Wong SP; Buning H; McIntosh J; Baker A; Nathwani AC; Thrasher A; et alCoutelle C; McKay TR; Waddington S. (14 Aug 2008). Luciferin detection after intra-nasal vector delivery is improved by intra-nasal rather than intra-peritoneal luciferin administration. Hum Gene Ther. DOI.
  • Argyros O; Wong SP; Niceta M; Waddington SN; Howe SJ; Coutelle C; Miller AD; Harbottle RP. (Dec 2008). Persistent episomal transgene expression in liver following delivery of a scaffold/matrix attachment region containing non-viral vector. Gene Ther. 15:1593-1605. DOI.
  • Buckley SM; Howe SJ; Sheard V; Ward NJ; Coutelle C; Thrasher AJ; Waddington SN; McKay TR. (Aug 2008). Lentiviral transduction of the murine lung provides efficient pseudotype and developmental stage-dependent cell-specific transgene expression. Gene Ther. 15:1167-1175. DOI.
  • Buckley SM; Waddington SN; Jezzard S; Bergau A; Themis M; MacVinish LJ; Cuthbert AW; Colledge WH; et alCoutelle C. (May 2008). Intra-amniotic delivery of CFTR-expressing adenovirus does not reverse cystic fibrosis phenotype in inbred CFTR-knockout mice. Mol Ther. 16:819-824. DOI.
  • Coutelle C. (Feb 2008). Why bother? Is in utero gene therapy worth the effort?. Mol Ther. 16:219-220. DOI.
  • Waddington SN; Buckley SM; David AL; Peebles DM; Rodeck CH; Coutelle C. (Oct 2007). Fetal gene transfer. Curr Opin Mol Ther. 9:432-438.
  • Coutelle C; Rodeck C. (Jun 2002). On the scientific and ethical issues of fetal somatic gene therapy. GENE THER. 9:670-673.
  • Waddington SN; Kennea NL; Buckley SMK; Gregory LG; Themis M; Coutelle C. (Oct 2004). Fetal and neonatal gene therapy: benefits and pitfalls. GENE THER. 11:S92-S97.
  • Schneider H; Muhle C; Douar AM; Waddington S; Jiang QJ; der Mark K; Coutelle C; Rascher W. (2002). Sustained delivery of therapeutic concentrations of human clotting factor IX - a comparison of adenoviral and AAV vectors administered in utero. J Gene Med. 1, 4:46-53.
  • Jost PJ; Harbottle RP; Knight A; Miller AD; Coutelle C; Schneider H. (2001). A novel peptide, THALWHT, for targeted gene delivery into human airway epithelia. Febs lett. 489:263-269.
  • David AL; Themis M; Cook T; Coutelle C; Rodeck C. (2001). Fetal gene therapy. Ultrasound Rev Obstet Gynecol. 1, 1:14-27.
  • Colin M; Moritz S; Fortanges P; Kornprobst M; Delouis C; Keller M; Miller AD; Capeau J; et alCoutelle C. (2001). The nuclear pore complex is involved in nuclear transfer of plasmid DNA condensed with an oligolysine-RGD peptide containing nuclear localisation properties. Gene Ther. 8:1643-1653.
  • Bakhai A; Sheridan DJ; Coutelle C. (2002). Bronchial artery delivery of viral vectors for gene delivery in cystic fibrosis; superior to airway delivery?. BMC Pulmonary Medicine. 1, 2:2.
  • Tolmachov O; Coutelle C. (2007). Covalent attachment of multifunctional chimeric terminal proteins to 5' DNA ends: A potential new strategy for assembly of synthetic therapeutic gene vectors. Med Hypotheses. 68:328-331. DOI.
  • Hibbitt OC; Harbottle RP; Waddington SN; Bursill CA; Coutelle C; Channon KM; Wade-Martins R. (Jun 2007). Delivery and long-term expression of a 135 kb LDLR genomic DNA locus in vivo by hydrodynamic tail vein injection. J Gene Med. 9:488-497. DOI.
  • David AL; Peebles DM; Gregory L; Waddington SN; Themis M; Weisz B; Ruthe A; Lawrence L; et alCook T; Rodeck CH; Coutelle C. (Jul 2006). Clinically applicable procedure for gene delivery to fetal gut by ultrasound-guided gastric injection: toward prenatal prevention of early-onset intestinal diseases. Hum Gene Ther. 17:767-779. DOI.
  • David AL; Weisz B; Gregory L; Themis M; Cook T; Roubliova X; Deprest J; Coutelle C; et alRodeck CH; Peebles DM. (Jul 2006). Ultrasound-guided injection and occlusion of the trachea in fetal sheep. Ultrasound Obstet Gynecol. 28:82-88. DOI.
  • David AL; Peebles DM; Gregory L; Waddington SN; Themis M; Weisz B; Ruthe A; Lawrence L; et alCook T; Rodeck CH; Coutelle C. (16 Jun 2006). Clinically Applicable Procedure for Gene Delivery to Fetal Gut by Ultrasound-Guided Gastric Injection: Toward Prenatal Prevention of Early-Onset Intestinal Diseases. Hum Gene Ther. Publisher weblink DOI.
  • Vaysse L; Gregory LG; Harbottle RP; Perouzel E; Tolmachov O; Coutelle C. (Jun 2006). Nuclear-targeted minicircle to enhance gene transfer with non-viral vectors in vitro and in vivo. J Gene Med. 8:754-763. DOI.
  • Tolmachov O; Ma YL; Themis M; Patel P; Spohr H; Macleod KT; Ullrich ND; Kienast Y; et alCoutelle C; Peters NS. (2006). Overexpression of connexin 43 using a retroviral vector improves electrical coupling of skeletal myoblasts with cardiac myocytes in vitro. BMC Cardiovasc Disord. 6:25. DOI.
  • Bigger BW; Siapati EK; Mistry A; Waddington SN; Nivsarkar MS; Jacobs L; Perrett R; Holder MV; et alRidler C; Kemball-Cook G; Ali RR; Forbes SJ; Coutelle C; Wright N; Alison M; Thrasher AJ; Bonnet D; Themis M. (Jan 2006). Permanent partial phenotypic correction and tolerance in a mouse model of hemophilia B by stem cell gene delivery of human factor IX. Gene Ther. 13:117-126. DOI.
  • Tolmachov O; Palaszewski I; Bigger B; Coutelle C. (2006). RecET driven chromosomal gene targeting to generate a RecA deficient Escherichia coli strain for Cre mediated production of minicircle DNA. BMC Biotechnol. 6:17. DOI.
  • Coutelle C; Themis M; Waddington SN; Buckley SM; Gregory LG; Nivsarkar MS; David AL; Peebles D; et alWeisz B; Rodeck C. (Nov 2005). Gene therapy progress and prospects: fetal gene therapy--first proofs of concept--some adverse effects. Gene Ther. 12:1601-1607. DOI.
  • Themis M; Waddington SN; Schmidt M; von Kalle C; Wang Y; Al-Allaf F; Gregory LG; Nivsarkar M; et alThemis M; Holder MV; Buckley SM; Dighe N; Ruthe AT; Mistry A; Bigger B; Rahim A; Nguyen TH; Trono D; Thrasher AJ; Coutelle C. (Oct 2005). Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice. Mol Ther. 12:763-771. DOI.
  • Buckley SM; Waddington SN; Jezzard S; Lawrence L; Schneider H; Holder MV; Themis M; Coutelle C. (Sep 2005). Factors influencing adenovirus-mediated airway transduction in fetal mice. Mol Ther. 12:484-492. DOI.
  • Weisz B; David AL; Gregory LG; Perocheau D; Ruthe A; Waddington SN; Themis M; Cook T; et alCoutelle C; Rodeck CH; Peebles DM. (Sep 2005). Targeting the respiratory muscles of fetal sheep for prenatal gene therapy for Duchenne muscular dystrophy. Am J Obstet Gynecol. 193:1105-1109. DOI.
  • Al-Allaf FA; Tolmachov O; Themis M; Coutelle C. (31 Aug 2005). Coupled analysis of bacterial transformants and ligation mixture by duplex PCR enables detection of fatal instability of a nascent recombinant plasmid. J Biochem Biophys Methods. 64:142-146. DOI.
  • Waterhouse JE; Harbottle RP; Keller M; Kostarelos K; Coutelle C; Jorgensen MR; Miller AD. (Jul 2005). Synthesis and application of integrin targeting lipopeptides in targeted gene delivery. Chembiochem. 6:1212-1223. DOI.
  • Waddington SN; Kramer MG; Hernandez-Alcoceba R; Buckley SM; Themis M; Coutelle C; Prieto J. (May 2005). In utero gene therapy: current challenges and perspectives. Mol Ther. 11:661-676. DOI.
  • Al-Allaf F; Tolmachov O; Themis M; Coutelle C. (15 Apr 2005). Accurate size gauging of ExoIII/S1-generated deletions by PCR analysis of ligation mixtures. Anal Biochem. 339:348-350. DOI.
  • Hoare J; Waddington S; Thomas HC; Coutelle C; McGarvey MJ. (Mar 2005). Complement inhibition rescued mice allowing observation of transgene expression following intraportal delivery of baculovirus in mice. J Gene Med. 7:325-333. DOI.
  • Waddington SN; Nivsarkar MS; Mistry AR; Buckley SM; Kemball-Cook G; Mosley KL; Mitrophanous K; Radcliffe P; et alHolder MV; Brittan M; Georgiadis A; Al-Allaf F; Bigger BW; Gregory LG; Cook HT; Ali RR; Thrasher A; Tuddenham EG; Themis M; Coutelle C. (1 Nov 2004). Permanent phenotypic correction of hemophilia B in immunocompetent mice by prenatal gene therapy. Blood. 104:2714-2721. DOI.
  • Gregory LG; Waddington SN; Holder MV; Mitrophanous KA; Buckley SM; Mosley KL; Bigger BW; Ellard FM; et alWalmsley LE; Lawrence L; Al-Allaf F; Kingsman S; Coutelle C; Themis M. (Jul 2004). Highly efficient EIAV-mediated in utero gene transfer and expression in the major muscle groups affected by Duchenne muscular dystrophy. Gene Ther. 11:1117-1125. DOI.
  • Waddington SN; Buckley SM; Bernloehr C; Bossow S; Ungerechts G; Cook T; Gregory L; Rahim A; et alThemis M; Neubert WJ; Coutelle C; Lauer UM; Bitzer M. (Apr 2004). Reduced toxicity of F-deficient Sendai virus vector in the mouse fetus. Gene Ther. 11:599-608. DOI.
  • Vaysse L; Harbottle R; Bigger B; Bergau A; Tolmachov O; Coutelle C. (13 Feb 2004). Development of a self-assembling nuclear targeting vector system based on the tetracycline repressor protein. J Biol Chem. 279:5555-5564. DOI.
  • Peebles D; Gregory LG; David A; Themis M; Waddington SN; Knapton HJ; Miah M; Cook T; et alLawrence L; Nivsarkar M; Rodeck C; Coutelle C. (Jan 2004). Widespread and efficient marker gene expression in the airway epithelia of fetal sheep after minimally invasive tracheal application of recombinant adenovirus in utero. Gene Ther. 11:70-78. DOI.
  • Coutelle C; Themis M; Waddington S; Gregory L; Nivsarkar M; Buckley S; Cook T; Rodeck C; et alPeebles D; David A. (Oct 2003). The hopes and fears of in utero gene therapy for genetic disease--a review. Placenta. 24 Suppl B:S114-S121.
  • Themis M; May D; Coutelle C; Newbold RF. (Sep 2003). Mutational effects of retrovirus insertion on the genome of V79 cells by an attenuated retrovirus vector: implications for gene therapy. Gene Ther. 10:1703-1711. DOI.
  • David AL; Peebles DM; Gregory L; Themis M; Cook T; Coutelle C; Rodeck CH. (Sep 2003). Percutaneous ultrasound-guided injection of the trachea in fetal sheep: a novel technique to target the fetal airways. Fetal Diagn Ther. 18:385-390. DOI.
  • Rahim A; Coutelle C; Harbottle R. (Aug 2003). High-throughput Pyrosequencing of a phage display library for the identification of enriched target-specific peptides. Biotechniques. 35:317-324.
  • Waddington SN; Mitrophanous KA; Ellard FM; Buckley SM; Nivsarkar M; Lawrence L; Cook HT; Al-Allaf F; et alBigger B; Kingsman SM; Coutelle C; Themis M. (Aug 2003). Long-term transgene expression by administration of a lentivirus-based vector to the fetal circulation of immuno-competent mice. Gene Ther. 10:1234-1240. DOI.
  • Keller M; Harbottle RP; Perouzel E; Colin M; Shah I; Rahim A; Vaysse L; Bergau A; et alMoritz S; Brahimi-Horn C; Coutelle C; Miller AD. (4 Apr 2003). Nuclear localisation sequence templated nonviral gene delivery vectors: investigation of intracellular trafficking events of LMD and LD vector systems. Chembiochem. 4:286-298. DOI.
  • David A; Cook T; Waddington S; Peebles D; Nivsarkar M; Knapton H; Miah M; Dahse T; et alNoakes D; Schneider H; Rodeck C; Coutelle C; Themis M. (1 Mar 2003). Ultrasound-guided percutaneous delivery of adenoviral vectors encoding the beta-galactosidase and human factor IX genes to early gestation fetal sheep in utero. Hum Gene Ther. 14:353-364. DOI.
  • Waddington SN; Buckley SM; Nivsarkar M; Jezzard S; Schneider H; Dahse T; Kemball-Cook G; Miah M; et alTucker N; Dallman MJ; Themis M; Coutelle C. (15 Feb 2003). In utero gene transfer of human factor IX to fetal mice can induce postnatal tolerance of the exogenous clotting factor. Blood. 101:1359-1366. DOI.
  • Gregory LG; Harbottle RP; Lawrence L; Knapton HJ; Themis M; Coutelle C. (Jan 2003). Enhancement of adenovirus-mediated gene transfer to the airways by DEAE dextran and sodium caprate in vivo. Mol Ther. 7:19-26.
  • Moritz S; Colin M; Keller M; Klonjkowski B; Capeau J; Coutelle C; Chroboczek J; Brahimi-Horn MC. (Jan 2003). Gene transfer by adenovirus-mimetic peptides in the presence of a cationic lipid and/or adenovirus. Analysis of the contribution of the viral and nonviral components. Arch Virol. 148:1-18. DOI.
  • Tagawa T; Manvell M; Brown N; Keller M; Perouzel E; Murray KD; Harbottle RP; Tecle M; et alBooy F; Brahimi-Horn MC; Coutelle C; Lemoine NR; Alton EW; Miller AD. (May 2002). Characterisation of LMD virus-like nanoparticles self-assembled from cationic liposomes, adenovirus core peptide mu and plasmid DNA. Gene Ther. 9:564-576. DOI.
  • McKay T; Reynolds P; Jezzard S; Curiel D; Coutelle C. (Apr 2002). Secretin-mediated gene delivery, a specific targeting mechanism with potential for treatment of biliary and pancreatic disease in cystic fibrosis. Mol Ther. 5:447-454. DOI.
  • Coutelle C; Bigger B. (Oct 2001). [Gene therapy of cystic fibrosis; review of completed clinical studies]. Internist (Berl). 42:1346-1356.
  • Bigger BW; Tolmachov O; Collombet JM; Fragkos M; Palaszewski I; Coutelle C. (22 Jun 2001). An araC-controlled bacterial cre expression system to produce DNA minicircle vectors for nuclear and mitochondrial gene therapy. J Biol Chem. 276:23018-23027. DOI.
  • Chan LM; Coutelle C; Themis M. (May 2001). A novel human suspension culture packaging cell line for production of high-titre retroviral vectors. Gene Ther. 8:697-703. DOI.
  • Jost PJ; Harbottle RP; Knight A; Miller AD; Coutelle C; Schneider H. (2 Feb 2001). A novel peptide, THALWHT, for the targeting of human airway epithelia. FEBS Lett. 489:263-269.
  • Coutelle C; Themis M; Schneider H; Kiserud T; Cook T; Douar AM; Hanson M; Pavirani A; et alRodeck C. (2001). Fetal somatic gene therapy--a preventive approach to the treatment of genetic disease: the case for. Ernst Schering Res Found Workshop. 99-114.
  • Bigger B; Coutelle C. (2001). Perspectives on gene therapy for cystic fibrosis airway disease. BioDrugs. 15:615-634.
  • Schneider H; Groves M; Mühle C; Reynolds PN; Knight A; Themis M; Carvajal J; Scaravilli F; et alCuriel DT; Fairweather NF; Coutelle C. (Sep 2000). Retargeting of adenoviral vectors to neurons using the Hc fragment of tetanus toxin. Gene Ther. 7:1584-1592. DOI.
  • Schneider H; Adebakin S; Themis M; Cook T; Douar AM; Pavirani A; Coutelle C. (Nov 1999). Therapeutic plasma concentrations of human factor IX in mice after gene delivery into the amniotic cavity: a model for the prenatal treatment of haemophilia B. J Gene Med. 1:424-432. DOI.
  • Schneider H; Coutelle C. (Mar 1999). In utero gene therapy: the case for. Nat Med. 5:256-257. DOI.

Chapters in books

  • Tolmachov O; Harbottle R; Bigger B; Coutelle C. Minimized, CpG-Depleted, and Methylated DNA Vectors: Toward Perfection in Nonviral Gene Therapy. In DNA-Pharmaceuticals: Formulation and Delivery in Gene Therapy, DNA Vaccination and Immunotherapy. 43-54. Schleef M (ed). Wiley (2005). Publisher weblink.
  • Schneider H; Coutelle C. Wege zur pr?natalen Gentherapie. 102-118. (2001).
  • Schneider H; Coutelle C. Gentherapie in utero. In Molekulare medizin in der Frauenheilkunde. 155-163. (2002).

Conferences

  • Argyros O; Wong S-P; Fedonidis C; Tolmachov O; Waddington S; Howe S; Coutelle C; Harbottle R. Development of Scaffold/Matrix Attachment Region (S/MAR) Minicircles for Enhanced and Persistent Transgene Expression in the Mouse Liver. 17th Annual Meeting of German Society for Gene Therapy (DG-GT e.V.), 7 Oct 2010 - 9 Oct 2010. 1197-1198. Mary Ann Liebert Inc Publishers (Sep 2010). Publisher weblink.
  • Buckley SMK; Waddington SN; Jezzard S; Bergau A; Themis M; MacVinish LJ; Cuthbert AW; Colledge WH; et alCoutelle C. Intra-amniotic delivery of CFTR expressing adenovirus does not reverse Cystic Fibrosis phenotype in inbred CFTR-knockout mice. 5th Annual Conference of the British-Society-for-Gene-Therapy. 19:414-414. (Apr 2008).
  • Argyros O; Wong SP; Nicetta M; Waddington SN; Coutelle C; Miller AD; Harbottle RP. Persistent episomal transgene expression in liver following hydrodynamic delivery of S/MAR-Containing plasmid DNA. 5th Annual Conference of the British-Society-for-Gene-Therapy. 19:399-399. (Apr 2008).
  • Argyros O; Wong SP; Niceta M; Waddington S; Coutelle C; Miller A; Harbottle R. Persistent episomal transgene expression in liver following hydrodynamic delivery of S/MAR-containing plasmid DNA. 15th Annual Congress of the European-Society-of-Gene-and-Cell-Therapy. 18:990-990. (Oct 2007).
  • Coutelle C. Targeted gene delivery: Variations on a common theme. 10th Meeting of the NATO-Advanced-Studies-Institue on Targeting of Drugs: Strategies for Gene Constructs and Delivery. 323:1-9. (2000).
  • Buckley SMK; Waddington SN; Jezzard S; Themis M; Colledge WH; Coutelle C. Intra-amniotic application of CFTR-expressing adenovirus does not reverse cystic fibrosis phenotype in inbred Cftr-knockout mice. 6th Annual Meeting of the American-Society-of-Gene-Therapy. 7:S200-S200. (May 2003).
  • Weisz B; David AL; Peebles DM; Gregory L; Perocheau D; Themis M; Terry C; Coutelle C; et alRodeck CH. Targeting the fetal gut for prenatal gene therapy. 51st Annual Meeting of the Society-for-Gynecologic-Investigation. 11:182A-182A. (Feb 2004).
  • Themis M; Gregory LG; Waddington SN; Holder MV; Mitrophanous KA; Buckley SMK; Bigger BW; Ellard FE; et alWalmsley LE; Radcliff P; Mazarakis N; Azzouz M; Lawrence L; Cook T; Allaf FA; Kingsman S; Coutelle C. The fetal approach: A novel therapy for the treatment of musculo-skeletal disease. 7th Annual Meeting of the American-Society-of-Gene-Therapy. 9:S91-S91. (May 2004).
  • Waddington SN; Nivsarkar MS; Mistry AR; Buckley SMK; Kemball-Cook G; Mosley KL; Mitrophanous K; Radcliffe P; et alHolder MV; Brittan M; Georgiadis T; Al-Allaf F; Bigger BW; Gregory LG; Cook TH; Ali RR; Thrasher A; Tuddenham EGD; Themis M; Coutelle C. Permanent phenotypic correction of haemophilia B in immunocompetent mice by prenatal gene therapy. 7th Annual Meeting of the American-Society-of-Gene-Therapy. 9:S15-S15. (May 2004).
  • Coutelle C. In utero gene therapy for genetic disease: animal models, target diseases and ethical considertions. 2nd European Conference and Practical Course on Towards Clinical Gene Therapy - Preclinical Gene Transfer Assessment. 11:S143-S143. (Oct 2004).
  • David AL; Peebles D; Gregory L; Themis M; Cook T; Nivsarkar M; Perocheau D; Weisz B; et alRodeck CH; Coutelle C. Towards prenatal gene therapy for cystic fibrosis: ultrasound guided delivery of recombinant adenoviral vectors to the fetal sheep trachea results in efficient marker gene expression in the airway epithelia. 1st Annual Conference of the British-Society-for-Gene-Therapy. 6:S20-S21. (Sep 2004).
  • Waddington SN; Nivsarkar M; Mistry A; Buckley SMK; Kemball-Cook G; Mosley KL; Mitrophanous K; Radcliffe P; et alHolder M; Brittan M; Georgiadis T; Al-Allaf F; Bigger B; Gregory L; Cook HT; Ali RR; Thrasher A; Tuddenham EGD; Themis M; Coutelle C. Permanent phenotypic correction of Haemophilia B in immunocompetent mice by prenatal gene therapy. 1st Annual Conference of the British-Society-for-Gene-Therapy. 6:S17-S17. (Sep 2004).
  • Weisz B; David A; Peebles D; Gregory L; Perocheau D; Waddington S; Themis M; Cook T; et alCoutelle C; Rodeck C. Targeting the fetal respiratory muscles for prenatal gene therapy for Duchenne muscular dystrophy. 25th Annual Meeting of the Society-for-Maternal-Fetal-Medicine. 191:S22-S22. (Dec 2004).
  • Themis M; Waddington SN; Schmidt M; von Kalle C; Wang YH; Al-Allaf F; Gregory L; Nivsarkar M; et alThemis M; Holder M; Buckley SMK; Dighe N; Ruthe A; Mistry A; Bigger B; Thrasher A; Coutelle C. Oncogenesis following delivery of a non-primate lentiviral gene therapy vector to fetal mice. Autumn Meeting of the British-Toxicology-Society. 219:233-233. (15 Feb 2006).
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