Dr Carel W Le Roux

Publications


Journals

  • Mathes CM; Bueter M; Smith KR; Lutz TA; Le Roux CW; Spector AC. (14 Dec 2011). Roux-en-Y Gastric Bypass in Rats Increases Sucrose Taste-Related Motivated Behavior Independent of Pharmacological GLP-1-Receptor Modulation. Am J Physiol Regul Integr Comp Physiol. DOI.
  • Atogo-Asse FE; Vincent RP; Hughes SA; Auzinger G; Le Roux CW; Wendon J; Bernal W. (Jan 2012). High density lipoprotein in patients with liver failure; relation to sepsis, adrenal function and outcome of illness. Liver Int. 32:128-136. DOI.
  • Fenske WK; Pournaras DJ; Aasheim ET; Miras AD; Scopinaro N; Scholtz S; le Roux CW. (Jan 2012). Can a protocol for glycaemic control improve type 2 diabetes outcomes after gastric bypass?. Obes Surg. 22:90-96. DOI.
  • Pournaras DJ; Aasheim ET; Søvik TT; Andrews R; Mahon D; Welbourn R; Olbers T; le Roux CW. (Jan 2012). Effect of the definition of type II diabetes remission in the evaluation of bariatric surgery for metabolic disorders. Br J Surg. 99:100-103. DOI.
  • Li JV; Reshat R; Wu Q; Ashrafian H; Bueter M; le Roux CW; Darzi A; Athanasiou T; et alMarchesi JR; Nicholson JK; Holmes E; Gooderham NJ. (2011). Experimental bariatric surgery in rats generates a cytotoxic chemical environment in the gut contents. Front Microbiol. 2:183. DOI.
  • Bueter M; le Roux CW. (Sep 2011). Gastrointestinal hormones, energy balance and bariatric surgery. Int J Obes (Lond). 35 Suppl 3:S35-S39. DOI.
  • Hall JI; Vora N; Langworthy R; Stock S; Momin A; Sherwood RA; le Roux CW; Alaghband-Zadeh J. (Jul 2011). Leptin/adiponectin ratio in patients with coronary heart disease: comparing subjects with and without metabolic syndrome. ANN CLIN BIOCHEM. 48:327-331. DOI.
  • Li JV; Ashrafian H; Bueter M; Kinross J; Sands C; le Roux CW; Bloom SR; Darzi A; et alAthanasiou T; Marchesi JR; Nicholson JK; Holmes E. (Sep 2011). Metabolic surgery profoundly influences gut microbial-host metabolic cross-talk. GUT. 60:1214-1223. DOI.
  • Bueter M; Miras AD; Chichger H; Fenske W; Ghatei MA; Bloom SR; Unwin RJ; Lutz TA; et alSpector AC; le Roux CW. (24 Oct 2011). Alterations of sucrose preference after Roux-en-Y gastric bypass. Physiol Behav. 104:709-721. DOI.
  • le Roux CW; Bueter M; Theis N; Werling M; Ashrafian H; Löwenstein C; Athanasiou T; Bloom SR; et alSpector AC; Olbers T; Lutz TA. (Oct 2011). Gastric bypass reduces fat intake and preference. Am J Physiol Regul Integr Comp Physiol. 301:R1057-R1066. DOI.
  • Parker HE; Wallis K; le Roux CW; Wong KY; Reimann F; Gribble FM. (Jan 2012). Molecular mechanisms underlying bile acid-stimulated glucagon-like peptide-1 secretion. Br J Pharmacol. 165:414-423. DOI.
  • Fenske WK; Bueter M; Miras AD; Ghatei MA; Bloom SR; le Roux CW. (21 Jun 2011). Exogenous peptide YY3-36 and Exendin-4 further decrease food intake, whereas octreotide increases food intake in rats after Roux-en-Y gastric bypass. Int J Obes (Lond). DOI.
  • Dixon AF; le Roux CW; Ghatei MA; Bloom SR; McGee TL; Dixon JB. (Dec 2011). Pancreatic polypeptide meal response may predict gastric band-induced weight loss. Obes Surg. 21:1906-1913. DOI.
  • Ashrafian H; le Roux CW; Rowland SP; Ali M; Cummin AR; Darzi A; Athanasiou T. (27 Jun 2011). Metabolic surgery and obstructive sleep apnoea: the protective effects of bariatric procedures. Thorax. DOI.
  • Seyfried F; le Roux CW; Bueter M. (Apr 2011). Lessons Learned from Gastric Bypass Operations in Rats. OBESITY FACTS. 4:3-12. DOI.
  • Li JV; Ashrafian H; Bueter M; Kinross J; Sands C; le Roux CW; Bloom SR; Darzi A; et alAthanasiou T; Marchesi JR; Nicholson JK; Holmes E. (Sep 2011). Metabolic surgery profoundly influences gut microbial-host metabolic cross-talk. Gut. 60:1214-1223. DOI.
  • Elnenaei MO; Alaghband-Zadeh J; Sherwood R; Awara MA; Moniz C; le Roux CW. (Sep 2011). Leptin and insulin growth factor 1: diagnostic markers of the refeeding syndrome and mortality. Br J Nutr. 106:906-912. DOI.
  • Hall JI; Vora N; Langworthy R; Stock S; Momin A; Sherwood RA; le Roux CW; Alaghband-Zadeh J. (Jul 2011). Leptin/adiponectin ratio in patients with coronary heart disease: comparing subjects with and without metabolic syndrome. Ann Clin Biochem. 48:327-331. DOI.
  • Beckman LM; Beckman TR; Sibley SD; Thomas W; Ikramuddin S; Kellogg TA; Ghatei MA; Bloom SR; et alle Roux CW; Earthman CP. (Mar 2011). Changes in gastrointestinal hormones and leptin after Roux-en-Y gastric bypass surgery. JPEN J Parenter Enteral Nutr. 35:169-180. DOI.
  • Ashrafian H; Athanasiou T; le Roux CW. (Feb 2011). Heart remodelling and obesity: the complexities and variation of cardiac geometry. Heart. 97:171-172. DOI.
  • Roberts RE; Glicksman C; Alaghband-Zadeh J; Sherwood RA; Akuji N; le Roux CW. (Jan 2011). The relationship between postprandial bile acid concentration, GLP-1, PYY and ghrelin. Clin Endocrinol (Oxf). 74:67-72. DOI.
  • Pournaras DJ; Osborne A; Hawkins SC; Vincent RP; Mahon D; Ewings P; Ghatei MA; Bloom SR; et alWelbourn R; le Roux CW. (Dec 2010). Remission of type 2 diabetes after gastric bypass and banding: mechanisms and 2 year outcomes. Ann Surg. 252:966-971. DOI.
  • Bueter M; Dubb SS; Gill A; Joannou L; Ahmed A; Frankel AH; Tam FW; le Roux CW. (Dec 2010). Renal cytokines improve early after bariatric surgery. Br J Surg. 97:1838-1844. DOI.
  • Glicksman C; Pournaras DJ; Wright M; Roberts R; Mahon D; Welbourn R; Sherwood R; Alaghband-Zadeh J; et alle Roux CW. (Sep 2010). Postprandial plasma bile acid responses in normal weight and obese subjects. Ann Clin Biochem. 47:482-484. DOI.
  • Bueter M; Ashrafian H; Frankel AH; Tam FW; Unwin RJ; le Roux CW. (Jan 2011). Sodium and water handling after gastric bypass surgery in a rat model. Surg Obes Relat Dis. 7:68-73. DOI.
  • le Roux CW; Borg C; Wallis K; Vincent RP; Bueter M; Goodlad R; Ghatei MA; Patel A; et alBloom SR; Aylwin SJ. (Jul 2010). Gut hypertrophy after gastric bypass is associated with increased glucagon-like peptide 2 and intestinal crypt cell proliferation. Ann Surg. 252:50-56. DOI.
  • Elnenaei MO; Musto R; Alaghband-Zadeh J; Moniz C; Le Roux CW. (Jul 2010). Postprandial bone turnover is independent of calories above 250 kcal. Ann Clin Biochem. 47:318-320. DOI.
  • Vincent RP; Goo CH; Wu PF; Delaney HL; le Roux CW. (Apr 2010). Influence of adherence to the national guidance on nutrition screening and dietitian referral on clinical outcomes of those requiring parenteral nutrition. J HUM NUTR DIET. 23:190-193. DOI.
  • Bueter M; Löwenstein C; Ashrafian H; Hillebrand J; Bloom SR; Olbers T; Lutz T; le Roux CW. (May 2010). Vagal sparing surgical technique but not stoma size affects body weight loss in rodent model of gastric bypass. Obes Surg. 20:616-622. DOI.
  • Vincent RP; Etogo-Asse FE; Dew T; Bernal W; Alaghband-Zadeh J; le Roux CW. (Nov 2009). Serum total cortisol and free cortisol index give different information regarding the hypothalamus-pituitary-adrenal axis reserve in patients with liver impairment. ANN CLIN BIOCHEM. 46:505-507. DOI.
  • Bueter M; Löwenstein C; Olbers T; Wang M; Cluny NL; Bloom SR; Sharkey KA; Lutz TA; et alle Roux CW. (May 2010). Gastric bypass increases energy expenditure in rats. Gastroenterology. 138:1845-1853. DOI.
  • Bueter M; Ashrafian H; le Roux CW. (2009). Mechanisms of Weight Loss after Gastric Bypass and Gastric Banding. OBESITY FACTS. 2:325-331. DOI.
  • Miras AD; le Roux CW. (Mar 2010). Bariatric surgery and taste: novel mechanisms of weight loss. Curr Opin Gastroenterol. 26:140-145. DOI.
  • Vincent RP; Aylwin SJB; le Roux CW. (Oct 2009). When the Brakes Came Off: Re-feeding Oedema after Deflation of a Gastric Band: A Case Report. OBES SURG. 19:1468-1470. DOI.
  • Bueter M; Thalheimer A; le Roux CW; Wierlemann A; Seyfried F; Fein M. (May 2010). Upper gastrointestinal investigations before gastric banding. Surg Endosc. 24:1025-1030. DOI.
  • Kokkinos A; le Roux CW; Alexiadou K; Tentolouris N; Vincent RP; Kyriaki D; Perrea D; Ghatei MA; et alBloom SR; Katsilambros N. (Jan 2010). Eating slowly increases the postprandial response of the anorexigenic gut hormones, peptide YY and glucagon-like peptide-1. J Clin Endocrinol Metab. 95:333-337. DOI.
  • Pournaras DJ; Osborne A; Hawkins SC; Mahon D; Ghatei MA; Bloom SR; Welbourn R; le Roux CW. (Jan 2010). The gut hormone response following Roux-en-Y gastric bypass: cross-sectional and prospective study. Obes Surg. 20:56-60. DOI.
  • le Roux CW; Murphy E; Hallam PA; McChesney SA; Lilburn MF; Lee PJ. (2005). NEUROPSYCHOMETRIC OUTCOME PREDICTORS FOR ADULTS WITH MAPLE SYRUP URINE DISEASE (MSUD). J INHERIT METAB DIS. 28:53-53.
  • Bueter M; Ahmed A; Ashrafian H; le Roux CW. (Sep 2009). Bariatric surgery and hypertension. Surg Obes Relat Dis. 5:615-620. DOI.
  • Sathyapalan T; Cho L; Kilpatrick ES; Le Roux CW; Coady AM; Atkin SL. (Mar 2010). Effect of rimonabant and metformin on glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 in obese women with polycystic ovary syndrome. Clin Endocrinol (Oxf). 72:423-425. DOI.
  • Pournaras DJ; le Roux CW. (Oct 2009). Obesity, gut hormones, and bariatric surgery. World J Surg. 33:1983-1988. DOI.
  • Alexandraki KI; Kaltsas GA; le Roux CW; Fassnacht M; Ajodha S; Christ-Crain M; Akker SA; Drake WM; et alEdwards R; Allolio B; Grossman AB. (Mar 2010). Assessment of serum-free cortisol levels in patients with adrenocortical carcinoma treated with mitotane: a pilot study. Clin Endocrinol (Oxf). 72:305-311. DOI.
  • Walters JR; Tasleem AM; Omer OS; Brydon WG; Dew T; le Roux CW. (Nov 2009). A new mechanism for bile acid diarrhea: defective feedback inhibition of bile acid biosynthesis. Clin Gastroenterol Hepatol. 7:1189-1194. DOI.
  • Bueter M; le Roux CW. (Aug 2009). Sir David Cuthbertson Medal Lecture. Bariatric surgery as a model to study appetite control. Proc Nutr Soc. 68:227-233. DOI.
  • Ashrafian H; le Roux CW. (14 Jul 2009). Metabolic surgery and gut hormones - a review of bariatric entero-humoral modulation. Physiol Behav. 97:620-631. DOI.
  • Pournaras DJ; le Roux CW. (Sep 2009). After bariatric surgery, what vitamins should be measured and what supplements should be given?. Clin Endocrinol (Oxf). 71:322-325. DOI.
  • Ashrafian H; le Roux CW; Darzi A; Athanasiou T. (11 Nov 2008). Effects of Bariatric Surgery on Cardiovascular Function. CIRCULATION. 118:2091-2102. DOI.
  • Murray CD; Le Roux CW; Emmanuel AV; Halket JM; Przyborowska AM; Kamm MA; Murray-Lyon IM. (Nov 2008). The effect of Khat (Catha edulis) as an appetite suppressant is independent of ghrelin and PYY secretion. Appetite. 51:747-750. DOI.
  • Vincent RP; le Roux CW. (May 2008). The satiety hormone peptide YY as a regulator of appetite. J CLIN PATHOL. 61:548-552. DOI.
  • Vincent RP; Ashrafian H; le Roux CW. (May 2008). Mechanisms of disease: the role of gastrointestinal hormones in appetite and obesity. Nat Clin Pract Gastroenterol Hepatol. 5:268-277. DOI.
  • le Roux CW; Borg CM; Murphy KG; Vincent RP; Ghatei MA; Bloom SR. (Jan 2008). Supraphysiological doses of intravenous PYY3-36 cause nausea, but no additional reduction in food intake. Ann Clin Biochem. 45:93-95. DOI.
  • Moran LJ; Noakes M; Clifton PM; Wittert GA; Le Roux CW; Ghatei MA; Bloom SR; Norman RJ. (Dec 2007). Postprandial ghrelin, cholecystokinin, peptide YY, and appetite before and after weight loss in overweight women with and without polycystic ovary syndrome. AM J CLIN NUTR. 86:1603-1610.
  • Vincent RP; le Roux CW. (Aug 2008). Changes in gut hormones after bariatric surgery. Clin Endocrinol (Oxf). 69:173-179. DOI.
  • Vincent RP; le Roux CW. (Dec 2007). New agents in development for the management of obesity. INT J CLIN PRACT. 61:2103-2112. DOI.
  • Borg CM; le Roux CW; Ghatei MA; Bloom SR; Patel AG. (Sep 2007). Biliopancreatic diversion in rats is associated with intestinal hypertrophy and with increased GLP-1, GLP-2 and PYY levels. Obes Surg. 17:1193-1198.
  • le Roux CW; Welbourn R; Werling M; Osborne A; Kokkinos A; Laurenius A; Lönroth H; Fändriks L; et alGhatei MA; Bloom SR; Olbers T. (Nov 2007). Gut hormones as mediators of appetite and weight loss after Roux-en-Y gastric bypass. Ann Surg. 246:780-785. DOI.
  • Germain N; Galusca B; Le Roux CW; Bossu C; Ghatei MA; Lang F; Bloom SR; Estour B. (Apr 2007). Constitutional thinness and lean anorexia nervosa display opposite concentrations of peptide YY, glucagon-like peptide 1, ghrelin, and leptin. Am J Clin Nutr. 85:967-971.
  • Vasilakopoulou A; le Roux CW. (Sep 2007). Could a virus contribute to weight gain?. Int J Obes (Lond). 31:1350-1356. DOI.
  • Batterham RL; Heffron H; Kapoor S; Chivers JE; Chandarana K; Herzog H; Le Roux CW; Thomas EL; et alBell JD; Withers DJ. (Sep 2006). Critical role for peptide YY in protein-mediated satiation and body-weight regulation. Cell Metab. 4:223-233. DOI.
  • Murray CD; le Roux CW; Gouveia C; Bassett P; Ghatei MA; Bloom SR; Emmanuel AV; Gabe SM. (Aug 2006). The effect of different macronutrient infusions on appetite, ghrelin and peptide YY in parenterally fed patients. Clin Nutr. 25:626-633. DOI.
  • Borg CM; le Roux CW; Ghatei MA; Bloom SR; Patel AG; Aylwin SJ. (Feb 2006). Progressive rise in gut hormone levels after Roux-en-Y gastric bypass suggests gut adaptation and explains altered satiety. Br J Surg. 93:210-215. DOI.
  • le Roux CW; Batterham RL; Aylwin SJ; Patterson M; Borg CM; Wynne KJ; Kent A; Vincent RP; et alGardiner J; Ghatei MA; Bloom SR. (Jan 2006). Attenuated peptide YY release in obese subjects is associated with reduced satiety. Endocrinology. 147:3-8. DOI.
  • le Roux CW; Aylwin SJ; Batterham RL; Borg CM; Coyle F; Prasad V; Shurey S; Ghatei MA; et alPatel AG; Bloom SR. (Jan 2006). Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters. Ann Surg. 243:108-114.
  • le Roux CW; Neary NM; Halsey TJ; Small CJ; Martinez-Isla AM; Ghatei MA; Theodorou NA; Bloom SR. (Aug 2005). Ghrelin does not stimulate food intake in patients with surgical procedures involving vagotomy. J Clin Endocrinol Metab. 90:4521-4524. DOI.
  • le Roux CW; Bloom SR. (May 2005). Peptide YY, appetite and food intake. Proc Nutr Soc. 64:213-216.
  • Patterson M; Murphy KG; le Roux CW; Ghatei MA; Bloom SR. (Apr 2005). Characterization of ghrelin-like immunoreactivity in human plasma. J Clin Endocrinol Metab. 90:2205-2211. DOI.
  • le Roux CW; Patterson M; Vincent RP; Hunt C; Ghatei MA; Bloom SR. (Feb 2005). Postprandial plasma ghrelin is suppressed proportional to meal calorie content in normal-weight but not obese subjects. J Clin Endocrinol Metab. 90:1068-1071. DOI.
  • le Roux CW; Ghatei MA; Gibbs JS; Bloom SR. (Feb 2005). The putative satiety hormone PYY is raised in cardiac cachexia associated with primary pulmonary hypertension. Heart. 91:241-242. DOI.
  • le Roux CW; Bloom SR. (Jan 2005). Why do patients lose weight after Roux-en-Y gastric bypass?. J Clin Endocrinol Metab. 90:591-592. DOI.
  • le Roux CW; Wilkinson SD; Pavitt DV; Muller BR; Alaghband-Zadeh J. (Jan 2004). A new antiglycolytic agent. Ann Clin Biochem. 41:43-46. DOI.
  • Cohen MA; Ellis SM; Le Roux CW; Batterham RL; Park A; Patterson M; Frost GS; Ghatei MA; et alBloom SR. (Oct 2003). Oxyntomodulin suppresses appetite and reduces food intake in humans. J Clin Endocrinol Metab. 88:4696-4701.
  • Batterham RL; Cohen MA; Ellis SM; Le Roux CW; Withers DJ; Frost GS; Ghatei MA; Bloom SR. (4 Sep 2003). Inhibition of food intake in obese subjects by peptide YY3-36. N Engl J Med. 349:941-948. DOI.
  • Batterham RL; Le Roux CW; Cohen MA; Park AJ; Ellis SM; Patterson M; Frost GS; Ghatei MA; et alBloom SR. (Aug 2003). Pancreatic polypeptide reduces appetite and food intake in humans. J Clin Endocrinol Metab. 88:3989-3992.
  • le Roux CW; Chapman GA; Kong WM; Dhillo WS; Jones J; Alaghband-Zadeh J. (May 2003). Free cortisol index is better than serum total cortisol in determining hypothalamic-pituitary-adrenal status in patients undergoing surgery. J Clin Endocrinol Metab. 88:2045-2048.
  • le Roux CW; Bloom SR. (Mar 2003). Clinical authorization: what is best for the patient?. Ann Clin Biochem. 40:113-114. DOI.
  • le Roux CW; Murphy E; Seed M. (Jul 2002). A retrospective assessment of the effectiveness of fenofibrate 267 mg on high-density lipoprotein cholesterol levels in patients attending a lipid clinic. Clin Ther. 24:1154-1160.
  • le Roux CW; Sivakumaran S; Alaghband-Zadeh J; Dhillo W; Kong WM; Wheeler MJ. (Jul 2002). Free cortisol index as a surrogate marker for serum free cortisol. Ann Clin Biochem. 39:406-408.
  • le Roux CW; Jenkins PJ; Chew SL; Camacho-Hübner C; Grossman AB; Besser GM; Monson JP. (Jul 2002). Growth hormone replacement does not increase serum prostate-specific antigen in hypopituitary men over 50 years. Eur J Endocrinol. 147:59-63.
  • Le Roux CW; Meeran K; Alaghband-Zadeh J. (Mar 2002). Is a 0900-h serum cortisol useful prior to a short synacthen test in outpatient assessment?. Ann Clin Biochem. 39:148-150.
  • Dhillo WS; Kong WM; Le Roux CW; Alaghband-Zadeh J; Jones J; Carter G; Mendoza N; Meeran K; et alO'Shea D. (Feb 2002). Cortisol-binding globulin is important in the interpretation of dynamic tests of the hypothalamic--pituitary--adrenal axis. Eur J Endocrinol. 146:231-235.
  • le Roux CW; Mulla A; Meeran K. (29 Nov 2001). Pituitary carcinoma as a cause of acromegaly. N Engl J Med. 345:1645-1646. DOI.
  • le Roux CW; Beckles MA; Besser GM; Pinching AJ; Davison AG. (Apr 2001). Cushing's syndrome secondary to inhaled corticosteroids mimicking HIV-associated lipodystrophy. HIV Med. 2:133-135.

Conferences

  • Pournaras DJ; Le Roux CW. The effect of bariatric surgery on gut hormones that alter appetite. 35:508-512. (Dec 2009).
  • Bueter M; le Roux CW. Sir David Cuthbertson Medal Lecture Bariatric surgery as a model to study appetite control. 68:227-233. (Aug 2009). DOI.
  • Ashrafian H; le Roux CW. Metabolic surgery and gut hormones - A review of bariatric entero-humoral modulation. 97:620-631. (14 Jul 2009). DOI.
  • Tadross JA; le Roux CW. The mechanisms of weight loss after bariatric surgery. 33:S28-S32. (Apr 2009). DOI.
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Dr Carel le Roux leads the clinical obesity program at the Imperial Weight Centre. The clinical service focuses on Lifestyle, Pharmacotherapy and Surgery as treatment options for patients with weight related medical co-morbidities. The research program has four major themes:

1. Changes in taste after weight loss

2. Changes in energy expenditure after weight loss

3. The role of bile metabolism after bariatric surgery

4. Clinical randomised controlled trials for weight loss

 The Imperial Weight Centre has several opportunities for research and clinical fellowships for physicians, surgeons and professionals allied to medicine.