Contact details
Dr Chris Murphy
I head a research group focused on chondrocyte biology in relation to cartilage repair. Areas of interest include hypoxia, microRNAs and stem cells.
Selected Publications
Journals
- Dudek K; Lafont J; Martinez-Sanchez A; Murphy CL. (Jun 2010). Type II Collagen Expression is Regulated by Tissue-specific miR-675 in Human Articular Chondrocytes. The Journal of Biological Chemistry. Epub ahead of print. Publisher weblink DOI.
- Thoms BL; Murphy CL. (Apr 2010). Inhibition of hypoxia-inducible factor-targeting prolyl hydroxylase domain-containing protein 2 (PHD2) enhances matrix synthesis by human chondrocytes. The Journal of Biological Chemistry. Epub ahead of print. Author weblink DOI.
- Jones SW; Watkins G; Le Good N; Roberts S; Murphy CL; Brockbank SMV; Needham MRC; Read SJ; et alNewham P. (Apr 2009). The identification of differentially expressed microRNA in osteoarthritic tissue that modulate the production of TNF-alpha and MMP13. OSTEOARTHR CARTILAGE. 17:464-472. DOI.
- Lafont JE; Talma S; Hopfgarten C; Murphy CL. (2008). Hypoxia promotes the differentiated human articular chondrocyte phenotype through SOX9-dependent and independent pathways. The Journal of Biological Chemistry. 283:4778-4786. Publisher weblink Author weblink DOI.
- Lafont JE; Talma S; Murphy CL. (Oct 2007). Hypoxia-Inducible Factor 2alpha is Essential for Hypoxic Induction of the Human Articular Chondrocyte Phenotype. Arthirtis and Rheumatism. 56:3297-3306. Publisher weblink DOI.
