Professor Christoph M Tang

Publications


Journals

  • Nagorska K; Silhan J; Li Y; Pelicic V; Freemont PS; Baldwin GS; Tang CM. (Mar 2012). A network of enzymes involved in repair of oxidative DNA damage in Neisseria meningitidis. Mol Microbiol. 83:1064-1079. DOI.
  • Silhan J; Nagorska K; Zhao Q; Jensen K; Freemont PS; Tang CM; Baldwin GS. (Mar 2012). Specialization of an Exonuclease III family enzyme in the repair of 3' DNA lesions during base excision repair in the human pathogen Neisseria meningitidis. Nucleic Acids Res. 40:2065-2075. DOI.
  • Tala A; Monaco C; Nagorska K; Exley RM; Corbett A; Zychlinsky A; Alifano P; Tang CM. (1 Sep 2011). Glutamate utilization promotes meningococcal survival in vivo through avoidance of the neutrophil oxidative burst. MOLECULAR MICROBIOLOGY. 81:1330-1342. Author weblink DOI.
  • Wong HE; Hey A; Tang CM; Kroll JS; Langford PR. (Jul 2011). Meningitis: latest developments. Future Microbiol. 6:721-723. DOI.
  • Quattroni P; Exley RM; Tang CM. (Aug 2011). New insights into pathogen recognition. Expert Rev Anti Infect Ther. 9:577-579. DOI.
  • Trivedi K; Tang CM; Exley RM. (Sep 2011). Mechanisms of meningococcal colonisation. Trends Microbiol. 19:456-463. DOI.
  • Talà A; Monaco C; Nagorska K; Exley RM; Corbett A; Zychlinsky A; Alifano P; Tang CM. (Sep 2011). Glutamate utilization promotes meningococcal survival in vivo through avoidance of the neutrophil oxidative burst. Mol Microbiol. 81:1330-1342. DOI.
  • Lucidarme J; Tan L; Exley RM; Findlow J; Borrow R; Tang CM. (Jun 2011). Characterization of Neisseria meningitidis isolates that do not express the virulence factor and vaccine antigen factor H binding protein. Clin Vaccine Immunol. 18:1002-1014. DOI.
  • Zhang Q; Li Y; Tang CM. (29 Oct 2010). The role of the exopolyphosphatase PPX in avoidance by Neisseria meningitidis of complement-mediated killing. J Biol Chem. 285:34259-34268. DOI.
  • Sutherland TC; Quattroni P; Exley RM; Tang CM. (Sep 2010). Transcellular passage of Neisseria meningitidis across a polarized respiratory epithelium. Infect Immun. 78:3832-3847. DOI.
  • Cehovin A; Winterbotham M; Lucidarme J; Borrow R; Tang CM; Exley RM; Pelicic V. (5 Jul 2010). Sequence conservation of pilus subunits in Neisseria meningitidis. Vaccine. 28:4817-4826. DOI.
  • Marteyn B; West NP; Browning DF; Cole JA; Shaw JG; Palm F; Mounier J; Prévost MC; et alSansonetti P; Tang CM. (20 May 2010). Modulation of Shigella virulence in response to available oxygen in vivo. Nature. 465:355-358. DOI.
  • Kugelberg E; Gollan B; Farrance C; Bratcher H; Lucidarme J; Ibarz-Pavón AB; Maiden MC; Borrow R; et alTang CM. (2010). The influence of IS1301 in the capsule biosynthesis locus on meningococcal carriage and disease. PLoS One. 5:e9413. DOI.
  • Tsolakos N; Lie K; Bolstad K; Maslen S; Kristiansen PA; Høiby EA; Wallington A; Vipond C; et alSkehel M; Tang CM; Feavers IM; Wedege E; Wheeler JX. (19 Apr 2010). Characterization of meningococcal serogroup B outer membrane vesicle vaccines from strain 44/76 after growth in different media. Vaccine. 28:3211-3218. DOI.
  • Chaudhuri RR; Sebaihia M; Hobman JL; Webber MA; Leyton DL; Goldberg MD; Cunningham AF; Scott-Tucker A; et alFerguson PR; Thomas CM; Frankel G; Tang CM; Dudley EG; Roberts IS; Rasko DA; Pallen MJ; Parkhill J; Nataro JP; Thomson NR; Henderson IR. (2010). Complete genome sequence and comparative metabolic profiling of the prototypical enteroaggregative Escherichia coli strain 042. PLoS One. 5:e8801. DOI.
  • Lucidarme J; Comanducci M; Findlow J; Gray SJ; Kaczmarski EB; Guiver M; Kugelberg E; Vallely PJ; et alOster P; Pizza M; Bambini S; Muzzi A; Tang CM; Borrow R. (1 Nov 2009). Characterization of fHbp, nhba (gna2132), nadA, porA, Sequence Type (ST), and Genomic Presence of IS1301 in Group B Meningococcal ST269 Clonal Complex Isolates from England and Wales. JOURNAL OF CLINICAL MICROBIOLOGY. 47:3577-3585. Author weblink DOI.
  • Heurlier K; Vendeville A; Halliday N; Green A; Winzer K; Tang CM; Hardie KR. (15 Aug 2009). Growth Deficiencies of Neisseria meningitidis pfs and luxS Mutants Are Not Due to Inactivation of Quorum Sensing (vol 191, pg 1293, 2009). JOURNAL OF BACTERIOLOGY. 191:5332-5332. Author weblink.
  • Lo H; Tang CM; Exley RM. (1 Jul 2009). Mechanisms of avoidance of host immunity by Neisseria meningitidis and its effect on vaccine development. LANCET INFECTIOUS DISEASES. 9:418-427. Author weblink.
  • Ray K; Marteyn B; Sansonetti PJ; Tang CM. (1 May 2009). Life on the inside: the intracellular lifestyle of cytosolic bacteria. NATURE REVIEWS MICROBIOLOGY. 7:333-340. Author weblink DOI.
  • Li Y; Wooldridge KG; Javed MA; Tang CM; Ala'aldeen DA. (14 Apr 2009). Secreted proteins of Neisseria meningitidis protect mice against infection. Vaccine. 27:2320-2325. DOI.
  • Schneider MC; Prosser BE; Caesar JJE; Kugelberg E; Li S; Zhang Q; Quoraishi S; Lovett JE; et alDeane JE; Sim RB; Roversi P; Johnson S; Tang CM; Lea SM. (16 Apr 2009). Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates. NATURE. 458:890-U9. Author weblink DOI.
  • Kugelberg E; Gollan B; Tang CM. (30 Dec 2008). Mechanisms in Neisseria meningitidis for resistance against complement-mediated killing. Vaccine. 26 Suppl 8:I34-I39.
  • Exley RM; Sim R; Goodwin L; Winterbotham M; Schneider MC; Read RC; Tang CM. (1 Jan 2009). Identification of Meningococcal Genes Necessary for Colonization of Human Upper Airway Tissue. INFECTION AND IMMUNITY. 77:45-51. Author weblink DOI.
  • Heurlier K; Vendeville A; Halliday N; Green A; Winzer K; Tang CM; Hardie KR. (15 Feb 2009). Growth Deficiencies of Neisseria meningitidis pfs and luxS Mutants Are Not Due to Inactivation of Quorum Sensing. JOURNAL OF BACTERIOLOGY. 191:1293-1302. Author weblink DOI.
  • Jose Uria M; Zhang Q; Li Y; Chan A; Exley RM; Gollan B; Chan H; Feavers I; et alYarwood A; Abad R; Borrow R; Fleck RA; Mulloy B; Vazquez JA; Tang CM. (9 Jun 2008). A generic mechanism in Neisseria meningitidis for enhanced resistance against bactericidal antibodies. JOURNAL OF EXPERIMENTAL MEDICINE. 205:1423-1434. Author weblink DOI.
  • Schneider MC; Exley RM; Ram S; Sim RB; Tang CM. (1 May 2007). Interactions between Neisseria meningitidis and the complement system. TRENDS IN MICROBIOLOGY. 15:233-240. Author weblink DOI.
  • HENSEL M; TANG CM; ARST HN; HOLDEN DW. (1995). Regulation of fungal extracellular proteases and their role in mammalian pathogenesis. CAN J BOT. 73:S1065-S1070.
  • Carpenter E; Corbett A; Thomson H; Adacha J; Jensen K; Bergeron J; Kasampalidis I; Exley R; et alWinterbotham M; Tang C; Baldwin GS; Freemont P. (Mar 2007). AP endonuclease paralogues with distinct activities in DNA repair and bacterial pathogenesis. EMBO Journal. 5, 26:1363-1372.
  • Smith H; Tang CM; Exley RM. (Sep 2007). Effect of host lactate on gonococci and meningococci: new concepts on the role of metabolites in pathogenicity. Infect Immun. 75:4190-4198. DOI.
  • Exley RM; Wu H; Shaw J; Schneider MC; Smith H; Jerse AE; Tang CM. (Mar 2007). Lactate acquisition promotes successful colonization of the murine genital tract by Neisseria gonorrhoeae. Infect Immun. 75:1318-1324. DOI.
  • Mazurkiewicz P; Tang CM; Boone C; Holden DW. (Dec 2006). Signature-tagged mutagenesis: barcoding mutants for genome-wide screens. Nat Rev Genet. 7:929-939. DOI.
  • Li Y; Zhang Q; Winterbotham M; Mowe E; Gorringe A; Tang CM. (Nov 2006). Immunization with live Neisseria lactamica protects mice against meningococcal challenge and can elicit serum bactericidal antibodies. Infect Immun. 74:6348-6355. DOI.
  • Schneider MC; Exley RM; Chan H; Feavers I; Kang YH; Sim RB; Tang CM. (15 Jun 2006). Functional significance of factor H binding to Neisseria meningitidis. J Immunol. 176:7566-7575.
  • West N; Sansonetti P; Tang CM. (1 Jan 2002). High throughput in vivo screens: Signature-tagged mutagenesis. FUNCTIONAL MICROBIAL GENOMICS. 33:153-165. Author weblink.
  • Stabler RA; Marsden GL; Witney AA; Li YM; Bentley SD; Tang CM; Hinds J. (1 Sep 2005). Identification of pathogen-specific genes through microarray analysis of pathogenic and commensal Neisseria species. MICROBIOLOGY-SGM. 151:2907-2922. Author weblink DOI.
  • Corbett A; Exley R; Bourdoulous S; Tang CM. (9 Jul 2004). Interactions between Neisseria meningitidis and human cells that promote colonisation and disease. Expert Rev Mol Med. 6:1-14. DOI.
  • TANG CM; HOLDEN DW; AUFAUVREBROWN A; COHEN J. (1 Nov 1993). THE DETECTION OF ASPERGILLUS SPP BY THE POLYMERASE CHAIN-REACTION AND ITS EVALUATION IN BRONCHOALVEOLAR LAVAGE FLUID. AMERICAN REVIEW OF RESPIRATORY DISEASE. 148:1313-1317. Author weblink.
  • TANG CM; COHEN J. (1 Mar 1995). EMPIRICAL ANTIFUNGAL THERAPY. BAILLIERES CLINICAL INFECTIOUS DISEASES. 2:127-139.
  • Tang CM; Cohen J; Krausz T; Van Noorden S; Holden DW. (May 1993). The alkaline protease of Aspergillus fumigatus is not a virulence determinant in two murine models of invasive pulmonary aspergillosis. Infect Immun. 61:1650-1656.
  • Aufauvre-Brown A; Tang CM; Holden DW. (Jul 1993). Detection of gene-disruption events in Aspergillus transformants by polymerase chain reaction direct from conidiospores. Curr Genet. 24:177-178.
  • Holden DW; Tang CM; Smith JM. (1994). Molecular genetics of Aspergillus pathogenicity. Antonie Van Leeuwenhoek. 65:251-255.
  • Tang CM; Cohen J; Rees AJ; Holden DW. (Apr 1994). Molecular epidemiological study of invasive pulmonary aspergillosis in a renal transplantation unit. Eur J Clin Microbiol Infect Dis. 13:318-321.
  • Smith JM; Tang CM; Van Noorden S; Holden DW. (Dec 1994). Virulence of Aspergillus fumigatus double mutants lacking restriction and an alkaline protease in a low-dose model of invasive pulmonary aspergillosis. Infect Immun. 62:5247-5254.
  • Tang CM; Smith JM; Arst HN; Holden DW. (Dec 1994). Virulence studies of Aspergillus nidulans mutants requiring lysine or p-aminobenzoic acid in invasive pulmonary aspergillosis. Infect Immun. 62:5255-5260.
  • Sun Y; Li Y; Exley RM; Winterbotham M; Ison C; Smith H; Tang CM. (14 Jul 2005). Identification of novel antigens that protect against systemic meningococcal infection. Vaccine. 23:4136-4141. DOI.
  • Exley RM; Goodwin L; Mowe E; Shaw J; Smith H; Read RC; Tang CM. (Sep 2005). Neisseria meningitidis lactate permease is required for nasopharyngeal colonization. Infect Immun. 73:5762-5766. DOI.
  • Exley RM; Shaw J; Mowe E; Sun YH; West NP; Williamson M; Botto M; Smith H; et alTang CM. (16 May 2005). Available carbon source influences the resistance of Neisseria meningitidis against complement. J Exp Med. 201:1637-1645. DOI.
  • Vendeville A; Winzer K; Heurlier K; Tang CM; Hardie KR. (May 2005). Making 'sense' of metabolism: autoinducer-2, LuxS and pathogenic bacteria. Nat Rev Microbiol. 3:383-396. DOI.
  • West NP; Sansonetti P; Mounier J; Exley RM; Parsot C; Guadagnini S; Prévost MC; Prochnicka-Chalufour A; et alDelepierre M; Tanguy M; Tang CM. (25 Feb 2005). Optimization of virulence functions through glucosylation of Shigella LPS. Science. 307:1313-1317. DOI.
  • Li Y; Sun YH; Ison C; Levine MM; Tang CM. (Jan 2004). Vaccination with attenuated Neisseria meningitidis strains protects against challenge with live Meningococci. Infect Immun. 72:345-351.
  • West NP; Sansonetti PJ; Frankel G; Tang CM. (Jul 2003). Finding your niche: what has been learnt from STM studies on GI colonization. Trends Microbiol. 11:338-344.
  • Greiner O; Berger C; Day PJ; Meier G; Tang CM; Nadal D. (Nov 2002). Rates of detection of Neisseria meningitidis in tonsils differ in relation to local incidence of invasive disease. J Clin Microbiol. 40:3917-3921.
  • Herbert MA; Hayes S; Deadman ME; Tang CM; Hood DW; Moxon ER. (Nov 2002). Signature Tagged Mutagenesis of Haemophilus influenzae identifies genes required for in vivo survival. Microb Pathog. 33:211-223.
  • Bahrani-Mougeot FK; Buckles EL; Lockatell CV; Hebel JR; Johnson DE; Tang CM; Donnenberg MS. (Aug 2002). Type 1 fimbriae and extracellular polysaccharides are preeminent uropathogenic Escherichia coli virulence determinants in the murine urinary tract. Mol Microbiol. 45:1079-1093.
  • Buisine N; Tang CM; Chalmers R. (3 Jul 2002). Transposon-like Correia elements: structure, distribution and genetic exchange between pathogenic Neisseria sp. FEBS Lett. 522:52-58.
  • Winzer K; Sun YH; Green A; Delory M; Blackley D; Hardie KR; Baldwin TJ; Tang CM. (Apr 2002). Role of Neisseria meningitidis luxS in cell-to-cell signaling and bacteremic infection. Infect Immun. 70:2245-2248.
  • Tang CM; Stroud D; Mackinnon F; Makepeace K; Plested J; Moxon ER; Chalmers R. (6 Feb 2002). Genetic linkage analysis to identify a gene required for the addition of phosphoethanolamine to meningococcal lipopolysaccharide. Gene. 284:133-140.
  • Mackinnon FG; Cox AD; Plested JS; Tang CM; Makepeace K; Coull PA; Wright JC; Chalmers R; et alHood DW; Richards JC; Moxon ER. (Feb 2002). Identification of a gene (lpt-3) required for the addition of phosphoethanolamine to the lipopolysaccharide inner core of Neisseria meningitidis and its role in mediating susceptibility to bactericidal killing and opsonophagocytosis. Mol Microbiol. 43:931-943.

Conferences

  • Everett J; Lea SM; Caesar JJE; Johnson S; Tang CM. Investigating host specificity of Neisseria meningitidis. 13th European Meeting on Complement in Human Disease, 21 Aug 2011 - 24 Aug 2011. 48:1673-1673. PERGAMON-ELSEVIER SCIENCE LTD (1 Aug 2011). Author weblink DOI.
  • Schneider MC; Prosser B; Kugelberg E; Sim RB; Lea S; Tang CM. Interactions between factor H and Neisseria meningitides. 11th European Meeting on Complement in Human Disease, 8 Sep 2007 - 11 Sep 2007. 44:3980-3980. PERGAMON-ELSEVIER SCIENCE LTD (1 Sep 2007). Author weblink DOI.
  • HENSEL M; TANG CM; ARST HN; HOLDEN DW. REGULATION OF FUNGAL EXTRACELLULAR PROTEASES AND THEIR ROLE IN MAMMALIAN PATHOGENESIS. 5th International Mycological Congress, 14 Aug 1994 - 21 Aug 1994. 73:S1065-S1070. NATL RESEARCH COUNCIL CANADA (1 Jan 1995). Author weblink.
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