Dr Charlotte Manisty

Charlotte Manisty is a NIHR Clinical Lecturer and  specialist registrar in cardiology at the National Heart and Lung Institute.  Her principal interest is in cardiovascular physiology and imaging, with particular focus on heart failure. 

Her undergraduate training was at Oxford University and Imperial College, and her early clinical years were spent in London teaching hospitals.  She was then awarded a Wellcome Clinical Training Fellowship to undertake research with Dr Darrel Francis in 2004, for which she was awarded a PhD for her work on periodic breathing in heart failure.  She completed further clinical training as a Specialist Registrar on the North West Thames cardiology rotation and was then awarded a NIHR Clinical Lecturer post at Imperial College in 2010.

Her PhD investigated the pathophysiology of periodic breathing in heart failure, and developed novel dynamic therapies based on reducing the cyclical oscillations in ventilation via pacemaker modulation.  She has also investigated the mechanism of action of the different classes of antihypertensive drugs using non-invasive wave intensity analysis, in a subset of the ASCOT trial.  She is also interested in improving non-invasive algorithms for optimisation of biventricular pacemakers, in order to maximise the haemodynamic and clinical response of the devices.

Her main clinical interest is in imaging, and she has BSE transthoracic and transoesophageal echocardiography accreditation, and performs clinical cardiac MRI.