Dr Charlotte Manisty

Publications


Journals

  • Baruah R; Giannoni A; Willson K; Manisty CH; Fontana M; Mebrate Y; Yadav H; Unsworth B; et alKyriacou A; Sen S; Sutton R; Kanagaratnam P; Hughes AD; Mayet J; Francis DP. (23 Nov 2010). Timely Modulation of Cardiac Output by a Pacemaker Can Stabilize Induced Periodic Breathing. CIRCULATION. 122. Author weblink.
  • Manisty C; Giannoni A; Mebrate Y; Mayet J; Willson K; Francis DP. (22 Nov 2011). Inverse Frequency Dependence of the Chemoreflex - is the Gain Measured with Rebreathing Relevant to Periodic Breathing in Heart Failure?. CIRCULATION. 124. Author weblink.
  • Jabbour R; Husain S; Zaman N; Aung N; Ling HZ; Baruah R; Cole G; Manisty C; et alBarron A; Mayet J; Francis D; Thomas M; Woldman S; Okonko DO. (22 Nov 2011). Attenuations in Serum Albumin Over Time Powerfully Predict an Amplified Risk of Death in Chronic Heart Failure. CIRCULATION. 124. Author weblink.
  • Moraldo M; Bergamini C; Malaweera AS; Dhutia NM; Pabari PA; Willson K; Baruah R; Manisty C; et alDavies JE; Xu XY; Hughes AD; Francis DP. (2 Jan 2012). A novel fully automated method for mitral regurgitant orifice area quantification. Int J Cardiol. DOI.
  • Lota AS; Manisty CH; Sutton R; Francis DP. (20 Dec 2011). CHRISTMAS 2011: PROFESSIONAL MATTERS When is a "free" registrar in clinic not free?. BRITISH MEDICAL JOURNAL. 343. Author weblink DOI.
  • Manisty CH; Al-Hussaini A; Unsworth B; Baruah R; Pabari PA; Mayet J; Hughes AD; Whinnett ZI; et alFrancis DP. (1 Feb 2012). The acute effects of changes to AV delay on BP and stroke volume: potential implications for design of pacemaker optimization protocols. Circ Arrhythm Electrophysiol. 5:122-130. DOI.
  • Baruah R; Giannoni A; Willson K; Mebrate Y; Mayet J; Emdin M; Hughes AD; Manisty CH; et alFrancis DP. (26 Apr 2011). Real-Time Dynamic Carbon Dioxide Administration Reply. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 57:1789-1790. Author weblink DOI.
  • Lota AS; Manisty CH; Sutton R; Francis DP. (2011). When is a "free" registrar in clinic not free?. BMJ. 343:d7869.
  • Giannoni A; Baruah R; Willson K; Mebrate Y; Mayet J; Emdin M; Hughes AD; Manisty CH; et alFrancis DP. (23 Nov 2010). Real-time dynamic carbon dioxide administration: a novel treatment strategy for stabilization of periodic breathing with potential application to central sleep apnea. J Am Coll Cardiol. 56:1832-1837. DOI.
  • Whinnett ZI; Nott G; Davies JE; Willson K; Manisty CH; Kanagaratnam P; Peters NS; Davies DW; et alHughes AD; Mayet J; Francis DP. (Feb 2011). Maximizing efficiency of alternation algorithms for hemodynamic optimization of the AV delay of cardiac resynchronization therapy. Pacing Clin Electrophysiol. 34:217-225. DOI.
  • Manisty C; Mayet J; Tapp RJ; Parker KH; Sever P; Poulter NR; Thom SA; Hughes AD; et alASCOT Investigators. (29 Jun 2010). Wave reflection predicts cardiovascular events in hypertensive individuals independent of blood pressure and other cardiovascular risk factors: an ASCOT (Anglo-Scandinavian Cardiac Outcome Trial) substudy. J Am Coll Cardiol. 56:24-30. DOI.
  • Davies JE; Baksi J; Francis DP; Hadjiloizou N; Whinnett ZI; Manisty CH; Aguado-Sierra J; Foale RA; et alMalik IS; Tyberg JV; Parker KH; Mayet J; Hughes AD. (Feb 2010). The arterial reservoir pressure increases with aging and is the major determinant of the aortic augmentation index. Am J Physiol Heart Circ Physiol. 298:H580-H586. DOI.
  • Manisty C; Mayet J; Tapp RJ; Sever PS; Poulter N; McG Thom SA; Hughes AD; ASCOT Investigators. (Nov 2009). Atorvastatin treatment is associated with less augmentation of the carotid pressure waveform in hypertension: a substudy of the Anglo-Scandinavian Cardiac Outcome Trial (ASCOT). Hypertension. 54:1009-1013. DOI.
  • Manisty CH; Zambanini A; Parker KH; Davies JE; Francis DP; Mayet J; Thom SAM; Hughes AD. (1 Oct 2009). Differences in the Magnitude of Wave Reflection Account for Differential Effects of Amlodipine- Versus Atenolol-Based Regimens on Central Blood Pressure An Anglo-Scandinavian Cardiac Outcome Trial Substudy. HYPERTENSION. 54:724-U73. Author weblink DOI.
  • Mebrate Y; Willson K; Manisty CH; Baruah R; Mayet J; Hughes AD; Parker KH; Francis DP. (1 Sep 2009). Dynamic CO2 therapy in periodic breathing: a modeling study to determine optimal timing and dosage regimes. JOURNAL OF APPLIED PHYSIOLOGY. 107:696-706. Author weblink DOI.
  • Baruah R; Manisty CH; Giannoni A; Willson K; Mebrate Y; Baksi AJ; Unsworth B; Hadjiloizou N; et alSutton R; Mayet J; Francis DP. (1 May 2009). Novel Use of Cardiac Pacemakers in Heart Failure to Dynamically Manipulate the Respiratory System Through Algorithmic Changes in Cardiac Output. CIRCULATION-HEART FAILURE. 2:166-174. Author weblink DOI.
  • Raphael CE; Whinnett ZI; Davies JE; Fontana M; Ferenczi EA; Manisty CH; Mayet J; Francis DP. (1 Jan 2009). Quantifying the paradoxical effect of higher systolic blood pressure on mortality in chronic heart failure. HEART. 95:56-62. Author weblink DOI.
  • Whinnett ZI; Davies JER; Nott G; Willson K; Manisty CH; Peters NS; Kanagaratnam P; Davies DW; et alHughes AD; Mayet J; Francis DP. (26 Sep 2008). Efficiency, reproducibility and agreement of five different hemodynamic measures for optimization of cardiac resynchronization therapy. INTERNATIONAL JOURNAL OF CARDIOLOGY. 129:216-226. Author weblink DOI.
  • Manisty CH; Willson K; Davies JE; Whinnett ZI; Baruah R; Mebrate Y; Kanagaratnam P; Peters NS; et alHughes AD; Mayet J; Francis DP. (Jul 2008). Induction of oscillatory ventilation pattern using dynamic modulation of heart rate through a pacemaker. Am J Physiol Regul Integr Comp Physiol. 295:R219-R227. DOI.
  • Manisty CH; Francis DP. (1 Apr 2008). Ejection fraction: a measure of desperation?. HEART. 94:400-401. Author weblink DOI.
  • Whinnett ZI; Briscoe C; Davies JER; Willson K; Manisty CH; Davies W; Peters NS; Kanagaratnam P; et alHughes AD; Mayet J; Francis DP. (1 Mar 2008). The atrioventricular delay of cardiac resynchronization can be optimized hemodynamically during exercise and predicted from resting measurements. HEART RHYTHM. 5:378-386. Author weblink DOI.
  • Davies JE; Francis DP; Hadjiloizou N; Manisty CH; Aguado-Sierra J; Foale RA; Parker KH; Mayet J; et alHughes AD. (1 Oct 2007). Changes in arterial reservoir function, not wave reflection, account for the effect of ageing on pressure augmentation in the proximal aorta. JOURNAL OF HUMAN HYPERTENSION. 21:848-848. Author weblink.
  • Malaweera ASN; Davies JE; Hadjiloizou N; Manisty C; Zambanini A; Aguado-Sierra J; Thom SA; Parker KH; et alFrancis DP; Mayet J; Hughes AD. (1 Oct 2007). Pulsatile arterial pressure is predominantly determined by the aortic reservoir, which can be determined non-invasively from peripheral measurement sites. JOURNAL OF HUMAN HYPERTENSION. 21:849-850. Author weblink.
  • Raphael C; Briscoe C; Davies J; Ian Whinnett Z; Manisty C; Sutton R; Mayet J; Francis DP. (Apr 2007). Limitations of the New York Heart Association functional classification system and self-reported walking distances in chronic heart failure. Heart. 93:476-482. DOI.
  • Manisty CH; Francis DP. (1 Jan 2007). Point : Counterpoint: Increased mechanoreceptor/metaboreceptor stimulation explains the exaggerated exercise pressor reflex seen in heart failure. JOURNAL OF APPLIED PHYSIOLOGY. 102:501-501. Author weblink.
  • Manisty CH; Willson K; Wensel R; Whinnett ZI; Davies JE; Oldfield WL; Mayet J; Francis DP. (15 Nov 2006). Development of respiratory control instability in heart failure: a novel approach to dissect the pathophysiological mechanisms. J Physiol. 577:387-401. DOI.
  • Whinnett ZI; Davies JE; Willson K; Manisty CH; Chow AW; Foale RA; Davies DW; Hughes AD; et alMayet J; Francis DP. (Nov 2006). Haemodynamic effects of changes in atrioventricular and interventricular delay in cardiac resynchronisation therapy show a consistent pattern: analysis of shape, magnitude and relative importance of atrioventricular and interventricular delay. Heart. 92:1628-1634. DOI.
  • Davies JE; Whinnett ZI; Francis DP; Manisty CH; Aguado-Sierra J; Willson K; Foale RA; Malik IS; et alHughes AD; Parker KH; Mayet J. (11 Apr 2006). Evidence of a dominant backward-propagating "suction" wave responsible for diastolic coronary filling in humans, attenuated in left ventricular hypertrophy. Circulation. 113:1768-1778. DOI.
  • Manisty C; Waxman J. (13 Sep 2003). Doctors should not discuss resuscitation with terminally ill patients: FOR. BMJ. 327:614-615. DOI.
  • Manisty C; Waxman J. (13 Sep 2003). For and against - Doctors should not discuss resuscitation with terminally ill patients - For. BRITISH MEDICAL JOURNAL. 327:614-615. Author weblink DOI.

Conferences

  • Davies JE; Francis DP; Hadjiloizou N; Whinnett ZI; Manisty CH; Aguado-Sierra J; Malik IS; Parker KH; et alHughes AD; Mayet J. Augmentation of Coronary Blood Flow in Systole by Reflected Waves in the Proximal Aorta. World Congress on Medical Physics and Biomedical Engineering, 7 Sep 2009 - 12 Sep 2009. 25:61-64. SPRINGER (1 Jan 2010). Author weblink.
  • Pabari PA; Kyriacou A; Moraldo M; Manisty C; Hughes AD; Mayet J; Francis DP. OPTIMISATION OF VV DELAY OF CRT IS MORE REPRODUCIBLE USING PEAK VELOCITIES THAN USING VELOCITY TIME INTEGRAL, AS WELL AS BEING QUICKER. Annual Conference of the British-Cardiovascular-Society (BCS), 13 Jun 2011 - 15 Jun 2011. 97:A50-A51. B M J PUBLISHING GROUP (1 Jun 2011). Author weblink DOI.
  • Manisty CH; Unsworth B; Baruah R; Pabari P; Whinnett ZI; Mayet J; Francis DP. PRESSURE VS FLOW AS A GUIDE FOR PACEMAKER OPTIMISATION? THE ACUTE HAEMODYNAMIC EFFECTS OF CHANGES TO ATRIOVENTRICULAR DELAY. Annual Conference of the British-Cardiovascular-Society (BCS), 13 Jun 2011 - 15 Jun 2011. 97:A58-A58. B M J PUBLISHING GROUP (1 Jun 2011). DOI.
  • Baruah R; Giannoni A; Manisty C; Willson K; Mebrate Y; Kyriacou A; Sen S; Shanmuganathan M; et alUnsworth B; Yadav H; Davies J; Sutton R; Mayet J; Hughes A; Francis DP. PERIODIC BREATHING: NOVEL EXPERIMENTAL MODELS TO DEVELOP DYNAMIC THERAPIES. Annual Conference and Exhibition of the British-Cardiovascular-Society, 7 Jun 2010 - 9 Jun 2010. 96:A1-A1. B M J PUBLISHING GROUP (1 Jun 2010). Author weblink DOI.
  • Al-Hussaini A; Baksi AJ; Hadjiloizou N; Davies JE; Manisty C; Kyriacou A; Foale RA; Tillin T; et alParker KH; Francis DP; Mayet J; Hughes AD. HOW DOES WAVE INTENSITY CHANGE WITH HEART RATE? INSIGHT FROM CAROTID STUDY DURING PACING. 14th Annual Meeting of the European-Council-for-Cardiovascular-Research, 9 Oct 2009 - 11 Oct 2009. 54:1171-1171. LIPPINCOTT WILLIAMS & WILKINS (1 Nov 2009). Author weblink.
  • Baruah R; Manisty C; Baksi AJ; Unsworth B; Hadjiloizou N; Mayet J; Francis DP. Accounting for the biphasic change in blood pressure that occurs following cardiac pacemaker optimisation. 13th Annual Meeting of the European-Council-for-Cardiovascular-Research, 10 Oct 2008 - 12 Oct 2008. 52:763-763. LIPPINCOTT WILLIAMS & WILKINS (1 Oct 2008). Author weblink.
  • Baruah R; Manisty C; Willson K; Baksi AJ; Mebrate Y; Unsworth B; Hadjiloizou N; Mayet J; et alFrancis DP. Real-time ventilatory manipulation by cardiac pacemaker: minimising blood pressure changes. 13th Annual Meeting of the European-Council-for-Cardiovascular-Research. 52:763-763. (Oct 2008).
  • Unsworth B; Baksi AJ; Baruah R; Manisty C; Hadjiloizou N; Foale R; Mayet J; Francis DP. Why does ejection fraction not fall with age? Discriminating ventricular and atrial contributions to ejection fraction using 2D echo. 13th Annual Meeting of the European-Council-for-Cardiovascular-Research, 10 Oct 2008 - 12 Oct 2008. 52:763-763. LIPPINCOTT WILLIAMS & WILKINS (1 Oct 2008). Author weblink.
  • Davies JE; Whinnett ZI; Hadjiloizou N; Manisty CH; Hughes AD; Parker KH; Francis DP; Mayet J. Microcirculatory-originating pressure predominantly determines coronary blood flow in humans: Evaluation using wave intensity analysis. Annual Scientific Conference of the British-Cardiovascular-Society. 94:A121-+. (Jul 2008).
  • Malaweera ASN; Davies JE; Hadjiloizou N; Manisty C; Aguado-Sierra J; Zambanini A; Mayet J; Francis DP; et alParker KH; Hughes AD. Peripheral pulsatile arterial pressure is determined by the central reservoir, which is similar across different arterial sites. Annual Scientific Conference of the British-Cardiovascular-Society/British-Society-for-Cardiovascular-Research, 2 Jun 2008 - 4 Jun 2008. 94:A114-A115. B M J PUBLISHING GROUP (1 Jul 2008). Author weblink.
  • Davies JE; Hadjiloizou N; Manisty CH; Whinnett ZI; Francis DP; Parker KH; Mayet J; Hughes AD. Evidence to support the role of the aortic reservoir via a direct mechanism in determination of the pressure waveform with ageing. 57th Annual Scientific Session of the American-College-of-Cardiology, 29 Mar 2008 - 1 Apr 2008. 51:A339-A339. ELSEVIER SCIENCE INC (11 Mar 2008). Author weblink.
  • Hughes A; Manisty C; Zambanini A; Mayet J; Poulter N; Sever P; Parker K; Thom S. Lower augmentation index and wave reflection in hypertensive subjects treated with atorvastatin; An ASCOT-LLA substudy. 80th Annual Scientific Session of the American-Heart-Association, 4 Nov 2007 - 7 Nov 2007. 116:609-609. LIPPINCOTT WILLIAMS & WILKINS (16 Oct 2007). Author weblink.
  • Davies J; Hadjiloizou N; Manisty C; Whinnett Z; Foale R; Malik I; Hughes A; Parker K; et alDarrel D; Mayet J. A unifying explanation of the arterial pulse waveform in humans and the implications for central blood pressure augmentation. Annual Scientific Conference of the British-Cardiovascular-Society, 4 Jun 2007 - 7 Jun 2007. 93:A79-A80. B M J PUBLISHING GROUP (1 Jun 2007). Author weblink.
  • Manisty C; Davies J; Whinnett Z; Francis D; Zambanini A; Zambanini A; Curtis S; Thom S; et alHughes A; Mayet J. Differences in the magnitude rather than the timing of wave reflection can explain the ASCOT results. Annual Scientific Conference of the British-Cardiovascular-Society, 4 Jun 2007 - 7 Jun 2007. 93:A80-A80. B M J PUBLISHING GROUP (1 Jun 2007). Author weblink.
  • Davies JE; Francis DP; Manisty CH; Hadjiloizou N; Aguado-Sierra J; Malik IS; Foale RA; Hughes AD; et alParker KH; Mayet J. A unifying explanation of the aortic pulse waveform in humans. 56th Annual Scientific Session of the American-College-of-Cardiology, 24 Mar 2007 - 27 Mar 2007. 49:397A-398A. ELSEVIER SCIENCE INC (6 Mar 2007). Author weblink.
  • Manisty CH; Willson K; Wensel R; Whinnett ZI; Davies JE; Oldfield WLG; Mayet J; Francis DP. Apnoeic threshold: A true determinant of cardiorespiratory control stability or a marker of chemoreflex gain?. Winter Meeting of the British-Thoracic-Society/British-Lung-Foundation (BTS/BLF). 61:II48-II49. (Dec 2006).
  • Manisty CH; Willson K; Davies JE; Whinnett ZI; Oldfield WLG; Hughes A; Mayet J; Francis DP. Can cardiac pacemakers directly control ventilation?. Winter Meeting of the British-Thoracic-Society/British-Lung-Foundation (BTS/BLF). 61:II49-II49. (Dec 2006).
  • Manisty CH; Davies JE; Zambanini A; Curtis SL; Whinnett ZI; Thom SM; Francis DP; Hughes A; et alMayet J. Differential arterial wave reflection in ASCOT: An explanation for the results?. 79th Annual Scientific Session of the American-Heart-Association. 114:537-537. (31 Oct 2006).
  • Davies JE; Hadjiloizou N; Whinnett ZI; Francis DP; Manisty CH; Hughes AD; Parker KH; Mayet J. Evidence to support the augmentation of coronary blood flow in systole, by wave reflection from the aorta. World Congress of Cardiology, 2 Sep 2006 - 6 Sep 2006. 27:512-512. OXFORD UNIV PRESS (1 Aug 2006). Author weblink.
  • Whinnett Z; Davies J; Willson K; Manisty C; Chow A; Foale R; Davies D; Hughes A; et alMayet J; Francis D. Changes in atrioventricular delay of cardiac resynchronisation therapy have a significantly larger haemodynamic effect compared with altering interventricular delay. Annual Scientific Conference of the British-Society-Promoting-Cardiovascular-Health, 24 Apr 2006 - 27 Apr 2006. 92:A114-A115. B M J PUBLISHING GROUP (1 May 2006). Author weblink.
  • Davies J; Whinnett Z; Francis D; Manisty C; Willson K; Foale R; Malik I; Hughes A; et alParker K; Mayet J. Coronary blood flow is not augmented by aortic wave reflection: An invasive assessment using wave intensity analysis. Annual Scientific Conference of the British-Society-Promoting-Cardiovascular-Health, 24 Apr 2006 - 27 Apr 2006. 92:A35-A35. B M J PUBLISHING GROUP (1 May 2006). Author weblink.
  • Davies J; Whinnett Z; Francis D; Manisty C; Willson K; Foale R; Malik I; Hughes A; et alParker K; Mayet J. Evidence of a dominant backward-propagating "suction" wave, responsible for diastolic coronary filling in humans, attenuated in left ventricular hypertrophy. Annual Scientific Conference of the British-Society-Promoting-Cardiovascular-Health, 24 Apr 2006 - 27 Apr 2006. 92:A2-A3. B M J PUBLISHING GROUP (1 May 2006). Author weblink.
  • Manisty C; Davies J; Willson K; Whinnett Z; Hughes A; Mayet J; Francis D. Harnessing physiological cardiorespiratory interaction to modulate ventilation by dynamic changes in cardiac output. Annual Scientific Conference of the British-Society-Promoting-Cardiovascular-Health, 24 Apr 2006 - 27 Apr 2006. 92:A39-A40. B M J PUBLISHING GROUP (1 May 2006). Author weblink.
  • Manisty C; Davies J; Francis D; Zambanini A; Thom S; Hughes A; Mayet J. The protodiastolic expansion wave: A compensatory mechanism for the reduction in longitudinal relaxation velocity with ageing?. Annual Scientific Conference of the British-Society-Promoting-Cardiovascular-Health, 24 Apr 2006 - 27 Apr 2006. 92:A61-A62. B M J PUBLISHING GROUP (1 May 2006). Author weblink.
  • Manisty C; Davies J; Whinnett Z; Francis D; Zambanini A; Cunningham S; Thom S; Hughes A; et alMayet J. The role of wave reflection in the pathophysiology of hypertension: Assessed using non-invasive wave intensity analysis. Annual Scientific Conference of the British-Society-Promoting-Cardiovascular-Health. 92:A33-A33. (May 2006).
  • Whinnett ZI; Davies JER; Willson K; Manisty CH; Chow AW; Foale RA; Davies DW; Hughes AD; et alMayet J; Francis DP. The haemodynamic response to changes in atrioventricular and interventricular delay of cardiac resynchronization therapy closely fits a parabola, which may allow more efficient optimization. 55th Annual Scientific Session of the American-College-of-Cardiology, 11 Mar 2006 - 14 Mar 2006. 47:22A-22A. ELSEVIER SCIENCE INC (21 Feb 2006). Author weblink.
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