Professor David W Holden

Publications


Journals

  • Yu XJ; Liu M; Matthews S; Holden DW. (14 Oct 2011). Tandem translation generates a chaperone for the Salmonella type III secretion system protein SsaQ. J Biol Chem. 286:36098-36107. DOI.
  • Thompson JA; Liu M; Helaine S; Holden DW. (Jul 2011). Contribution of the PhoP/Q regulon to survival and replication of Salmonella enterica serovar Typhimurium in macrophages. Microbiology. 157:2084-2093. DOI.
  • Watson KG; Holden DW. (Oct 2010). Dynamics of growth and dissemination of Salmonella in vivo. Cell Microbiol. 12:1389-1397. DOI.
  • Dumont A; Boucrot E; Drevensek S; Daire V; Gorvel J-P; Poues C; Holden DW; Meresse S. (1 Jul 2010). SKIP, the Host Target of the Salmonella Virulence Factor SifA, Promotes Kinesin-1-Dependent Vacuolar Membrane Exchanges. TRAFFIC. 11:899-911. DOI.
  • Yu XJ; McGourty K; Liu M; Unsworth KE; Holden DW. (21 May 2010). pH sensing by intracellular Salmonella induces effector translocation. Science. 328:1040-1043. DOI.
  • Helaine S; Thompson JA; Watson KG; Liu M; Boyle C; Holden DW. (23 Feb 2010). Dynamics of intracellular bacterial replication at the single cell level. Proc Natl Acad Sci U S A. 107:3746-3751. DOI.
  • Groves E; Rittinger K; Amstutz M; Berry S; Holden DW; Cornelis GR; Caron E. (5 Feb 2010). Sequestering of Rac by the Yersinia effector YopO blocks Fcgamma receptor-mediated phagocytosis. J Biol Chem. 285:4087-4098. DOI.
  • Lapaque N; Hutchinson JL; Jones DC; Meresse S; Holden DW; Trowsdale J; Kelly AP. (18 Aug 2009). Salmonella regulates polyubiquitination and surface expression of MHC class II antigens. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 106:14052-14057. Author weblink DOI.
  • Mota LJ; Ramsden AE; Liu M; Castle JD; Holden DW. (1 Aug 2009). SCAMP3 is a component of the Salmonella-induced tubular network and reveals an interaction between bacterial effectors and post-Golgi trafficking. CELLULAR MICROBIOLOGY. 11:1236-1253. Author weblink DOI.
  • Thomas M; Holden DW. (23 Apr 2009). Ubiquitination-A Bacterial Effector's Ticket to Ride. CELL HOST & MICROBE. 5:309-311. Author weblink DOI.
  • Lossi NS; Rolhion N; Magee AI; Boyle C; Holden DW. (1 Sep 2008). The Salmonella SPI-2 effector SseJ exhibits eukaryotic activator-dependent phospholipase A and glycerophospholipid: cholesterol acyltransferase activity. MICROBIOLOGY-SGM. 154:2680-2688. DOI.
  • Poh J; Odendall C; Spanos A; Boyle C; Liu M; Freemont P; Holden DW. (1 Jan 2008). SteC is a Salmonella kinase required for SPI-2-dependent F-actin remodelling. CELLULAR MICROBIOLOGY. 10:20-30. Author weblink DOI.
  • Mazurkiewicz P; Thomas J; Thompson JA; Liu M; Arbibe L; Sansonetti P; Holden DW. (Mar 2008). SpvC is a Salmonella effector with phosphothreonine lyase activity on host mitogen-activated protein kinases. Mol Microbiol. 67:1371-1383. DOI.
  • Ramsden AE; Holden DW; Mota LJ. (1 Nov 2007). Membrane dynamics and spatial distribution of Salmonella-containing vacuoles. TRENDS IN MICROBIOLOGY. 15:516-524. Author weblink DOI.
  • Rytkoenen A; Holden DW. (1 Mar 2007). Bacterial interference of ubiquitination and deubiquitination. CELL HOST & MICROBE. 1:13-22. Author weblink DOI.
  • Nelson AL; Ries J; Bagnoli F; Dahlberg S; Falker S; Rounioja S; Tschop J; Morfeldt E; et alFerlenghi I; Hilleringmann M; Holden DW; Rappuoli R; Normark S; Barocchi MA; Henriques-Normark B. (1 Oct 2007). RrgA is a pilus-associated adhesin in Streptococcus pneumoniae. MOLECULAR MICROBIOLOGY. 66:329-340. Author weblink DOI.
  • HENSEL M; TANG CM; ARST HN; HOLDEN DW. (1995). Regulation of fungal extracellular proteases and their role in mammalian pathogenesis. CAN J BOT. 73:S1065-S1070.
  • Ramsden AE; Mota LJ; Münter S; Shorte SL; Holden DW. (Oct 2007). The SPI-2 type III secretion system restricts motility of Salmonella-containing vacuoles. Cell Microbiol. 9:2517-2529. DOI.
  • Rytkönen A; Poh J; Garmendia J; Boyle C; Thompson A; Liu M; Freemont P; Hinton JC; et alHolden DW. (27 Feb 2007). SseL, a Salmonella deubiquitinase required for macrophage killing and virulence. Proc Natl Acad Sci U S A. 104:3502-3507. DOI.
  • Mazurkiewicz P; Tang CM; Boone C; Holden DW. (Dec 2006). Signature-tagged mutagenesis: barcoding mutants for genome-wide screens. Nat Rev Genet. 7:929-939. DOI.
  • Deiwick J; Salcedo SP; Boucrot E; Gilliland SM; Henry T; Petermann N; Waterman SR; Gorvel JP; et alHolden DW; Méresse S. (Dec 2006). The translocated Salmonella effector proteins SseF and SseG interact and are required to establish an intracellular replication niche. Infect Immun. 74:6965-6972. DOI.
  • Unsworth KE; Mazurkiewicz P; Senf F; Zettl M; McNiven M; Way M; Holden DW. (Feb 2007). Dynamin is required for F-actin assembly and pedestal formation by enteropathogenic Escherichia coli (EPEC). Cell Microbiol. 9:438-449. DOI.
  • Barocchi MA; Rie J; Zogaj X; Hemsley C; Albiger B; Kanth A; Dahlberg S; Fernebro J; et alMoschioni M; Masignani V; Hultenby K; Taddei AR; Beiter K; Wartha F; von Euler A; Covacci A; Holden DW; Normark S; Rappuoli R; Henriques-Normark B. (21 Feb 2006). A pneumococcal pilus influences virulence and host inflammatory responses. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 103:2857-2862. Author weblink DOI.
  • Ygberg SE; Clements MO; Rytkonen A; Thompson A; Holden DW; Hinton JCD; Rhen M. (1 Feb 2006). Polynucleotide phosphorylase negatively controls spv virulence gene expression in Salmonella enterica. INFECTION AND IMMUNITY. 74:1243-1254. Author weblink DOI.
  • Mota LJ; Holden DW. (1 Dec 2005). FlAsHlights on bacterial virulence proteins. NATURE METHODS. 2:898-899. Author weblink DOI.
  • Yuste J; Botto M; Paton JC; Holden DW; Brown JS. (1 Aug 2005). Additive inhibition of complement deposition by pneumolysin and PspA facilitates Streptococcus pneumoniae septicemia. J Immunol. 175:1813-1819.
  • Linehan SA; Rytkönen A; Yu XJ; Liu M; Holden DW. (Jul 2005). SlyA regulates function of Salmonella pathogenicity island 2 (SPI-2) and expression of SPI-2-associated genes. Infect Immun. 73:4354-4362. DOI.
  • Hisert KB; MacCoss M; Shiloh MU; Darwin KH; Singh S; Jones RA; Ehrt S; Zhang Z; et alGaffney BL; Gandotra S; Holden DW; Murray D; Nathan C. (Jun 2005). A glutamate-alanine-leucine (EAL) domain protein of Salmonella controls bacterial survival in mice, antioxidant defence and killing of macrophages: role of cyclic diGMP. Mol Microbiol. 56:1234-1245. DOI.
  • Salcedo SP; Holden DW. (Feb 2005). Bacterial interactions with the eukaryotic secretory pathway. Curr Opin Microbiol. 8:92-98. DOI.
  • Unsworth KE; Way M; McNiven M; Machesky L; Holden DW. (Nov 2004). Analysis of the mechanisms of Salmonella-induced actin assembly during invasion of host cells and intracellular replication. Cell Microbiol. 6:1041-1055. DOI.
  • Brown JS; Gilliland SM; Ruiz-Albert J; Holden DW. (1 Nov 2004). Characterization of pit, a Streptococcus pneumoniae iron uptake ABC transporter (vol 70, pg 4389, 2004). INFECTION AND IMMUNITY. 72:6754-6754. DOI.
  • Brown JS; Ogunniyi AD; Woodrow MC; Holden DW; Paton JC. (1 Nov 2004). Immunization with components of two iron uptake ABC transporters protects mice against systemic Streptococcus pneumoniae infection (vol 69, pg 6702, 2004). INFECTION AND IMMUNITY. 72:6755-6755. Author weblink DOI.
  • Petrovska L; Aspinall RJ; Barber L; Clare S; Simmons CP; Stratford R; Khan SA; Lemoine NR; et alFrankel G; Holden DW; Dougan G. (Nov 2004). Salmonella enterica serovar Typhimurium interaction with dendritic cells: impact of the sifA gene. Cell Microbiol. 6:1071-1084. DOI.
  • Yu XJ; Liu M; Holden DW. (Nov 2004). SsaM and SpiC interact and regulate secretion of Salmonella pathogenicity island 2 type III secretion system effectors and translocators. Mol Microbiol. 54:604-619. DOI.
  • Brown JS; Gilliland SM; Basavanna S; Holden DW. (1 Aug 2004). phgABC, a three-gene operon required for growth of Streptococcus pneumoniae in hy erosmotic medium and in vivo. INFECTION AND IMMUNITY. 72:4579-4588. Author weblink DOI.
  • Brown JS; Gilliland SM; Spratt BG; Holden DW. (Mar 2004). A locus contained within a variable region of pneumococcal pathogenicity island 1 contributes to virulence in mice. Infect Immun. 72:1587-1593.
  • Guignot J; Caron E; Beuzón C; Bucci C; Kagan J; Roy C; Holden DW. (1 Mar 2004). Microtubule motors control membrane dynamics of Salmonella-containing vacuoles. J Cell Sci. 117:1033-1045. DOI.
  • Batchelor M; Guignot J; Patel A; Cummings N; Cleary J; Knutton S; Holden DW; Connerton I; et alFrankel G. (1 Jan 2004). Involvement of the intermediate filament protein cytokeratin-18 in actin pedestal formation during EPEC infection. EMBO REPORTS. 5:104-109. Author weblink DOI.
  • Salcedo SP; Holden DW. (1 Oct 2003). SseG, a virulence protein that targets Salmonella to the Golgi network. EMBO J. 22:5003-5014. DOI.
  • Ramos-Morales F; Prieto AI; Beuzón CR; Holden DW; Casadesús J. (Sep 2003). Role for Salmonella enterica enterobacterial common antigen in bile resistance and virulence. J Bacteriol. 185:5328-5332.
  • Garmendia J; Beuzón CR; Ruiz-Albert J; Holden DW. (Sep 2003). The roles of SsrA-SsrB and OmpR-EnvZ in the regulation of genes encoding the Salmonella typhimurium SPI-2 type III secretion system. Microbiology. 149:2385-2396.
  • Waterman SR; Holden DW. (1 Aug 2003). Functions and effectors of the Salmonella pathogenicity island 2 type III secretion system. CELLULAR MICROBIOLOGY. 5:501-511. Author weblink DOI.
  • Ruiz-Albert J; Mundy R; Yu XJ; Beuzón CR; Holden DW. (May 2003). SseA is a chaperone for the SseB and SseD translocon components of the Salmonella pathogenicity-island-2-encoded type III secretion system. Microbiology. 149:1103-1111.
  • Boucrot E; Beuzón CR; Holden DW; Gorvel JP; Méresse S. (18 Apr 2003). Salmonella typhimurium SifA effector protein requires its membrane-anchoring C-terminal hexapeptide for its biological function. J Biol Chem. 278:14196-14202. DOI.
  • Mellado E; Dubreucq G; Mol P; Sarfati J; Paris S; Diaquin M; Holden DW; Rodriguez-Tudela JL; et alLatgé JP. (Feb 2003). Cell wall biogenesis in a double chitin synthase mutant (chsG-/chsE-) of Aspergillus fumigatus. Fungal Genet Biol. 38:98-109.
  • Linehan SA; Holden DW. (22 Jan 2003). The interplay between Salmonella typhimurium and its macrophage host--what can it teach us about innate immunity?. Immunol Lett. 85:183-192.
  • Brown JS; Hussell T; Gilliland SM; Holden DW; Paton JC; Ehrenstein MR; Walport MJ; Botto M. (24 Dec 2002). The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice. Proc Natl Acad Sci U S A. 99:16969-16974. DOI.
  • Pawelek JM; Sodi S; Chakraborty AK; Platt JT; Miller S; Holden DW; Hensel M; Low KB. (Oct 2002). Salmonella pathogenicity island-2 and anticancer activity in mice. Cancer Gene Ther. 9:813-818. DOI.
  • Garvis S; Mei JM; Ruiz-Albert J; Holden DW. (Oct 2002). Staphylococcus aureus svrA: a gene required for virulence and expression of the agr locus. Microbiology. 148:3235-3243.
  • Beuzón CR; Salcedo SP; Holden DW. (Sep 2002). Growth and killing of a Salmonella enterica serovar Typhimurium sifA mutant strain in the cytosol of different host cell lines. Microbiology. 148:2705-2715.
  • Brown JS; Holden DW. (Sep 2002). Iron acquisition by Gram-positive bacterial pathogens. Microbes Infect. 4:1149-1156.
  • Brown JS; Gilliland SM; Ruiz-Albert J; Holden DW. (Aug 2002). Characterization of pit, a Streptococcus pneumoniae iron uptake ABC transporter. Infect Immun. 70:4389-4398.
  • Yu XJ; Ruiz-Albert J; Unsworth KE; Garvis S; Liu M; Holden DW. (Aug 2002). SpiC is required for secretion of Salmonella Pathogenicity Island 2 type III secretion system proteins. Cell Microbiol. 4:531-540.
  • Hindle Z; Chatfield SN; Phillimore J; Bentley M; Johnson J; Cosgrove CA; Ghaem-Maghami M; Sexton A; et alKhan M; Brennan FR; Everest P; Wu T; Pickard D; Holden DW; Dougan G; Griffin GE; House D; Santangelo JD; Khan SA; Shea JE; Feldman RG; Lewis DJ. (Jul 2002). Characterization of Salmonella enterica derivatives harboring defined aroC and Salmonella pathogenicity island 2 type III secretion system (ssaV) mutations by immunization of healthy volunteers. Infect Immun. 70:3457-3467.
  • Ruiz-Albert J; Yu XJ; Beuzón CR; Blakey AN; Galyov EE; Holden DW. (May 2002). Complementary activities of SseJ and SifA regulate dynamics of the Salmonella typhimurium vacuolar membrane. Mol Microbiol. 44:645-661.
  • Holden DW. (Mar 2002). Trafficking of the Salmonella vacuole in macrophages. Traffic. 3:161-169.
  • Brown JS; Ogunniyi AD; Gilliland SN; Woodrow MC; Holden DW; Paton JC. (1 Dec 2001). Immunisation with ABC transporter proteins protects against Streptococcus pneumoniae infection. THORAX. 56:26-26. Author weblink.
  • Beuzón CR; Unsworth KE; Holden DW. (Dec 2001). In vivo genetic analysis indicates that PhoP-PhoQ and the Salmonella pathogenicity island 2 type III secretion system contribute independently to Salmonella enterica serovar Typhimurium virulence. Infect Immun. 69:7254-7261. DOI.
  • Garvis SG; Beuzón CR; Holden DW. (Nov 2001). A role for the PhoP/Q regulon in inhibition of fusion between lysosomes and Salmonella-containing vacuoles in macrophages. Cell Microbiol. 3:731-744.
  • Brown JS; Ogunniyi AD; Woodrow MC; Holden DW; Paton JC. (Nov 2001). Immunization with components of two iron uptake ABC transporters protects mice against systemic Streptococcus pneumoniae infection. Infect Immun. 69:6702-6706. DOI.
  • Beuzón CR; Holden DW. (Nov 2001). Use of mixed infections with Salmonella strains to study virulence genes and their interactions in vivo. Microbes Infect. 3:1345-1352.
  • Webb JL; Harvey MW; Holden DW; Evans TJ. (Oct 2001). Macrophage nitric oxide synthase associates with cortical actin but is not recruited to phagosomes. Infect Immun. 69:6391-6400. DOI.
  • Salcedo SP; Noursadeghi M; Cohen J; Holden DW. (Sep 2001). Intracellular replication of Salmonella typhimurium strains in specific subsets of splenic macrophages in vivo. Cell Microbiol. 3:587-597.
  • Méresse S; Unsworth KE; Habermann A; Griffiths G; Fang F; Martínez-Lorenzo MJ; Waterman SR; Gorvel JP; et alHolden DW. (Aug 2001). Remodelling of the actin cytoskeleton is essential for replication of intravacuolar Salmonella. Cell Microbiol. 3:567-577.
  • Lau GW; Haataja S; Lonetto M; Kensit SE; Marra A; Bryant AP; McDevitt D; Morrison DA; et alHolden DW. (May 2001). A functional genomic analysis of type 3 Streptococcus pneumoniae virulence. Mol Microbiol. 40:555-571.
  • Brown JS; Gilliland SM; Holden DW. (May 2001). A Streptococcus pneumoniae pathogenicity island encoding an ABC transporter involved in iron uptake and virulence. Mol Microbiol. 40:572-585.
  • Yu J; Bryant AP; Marra A; Lonetto MA; Ingraham KA; Chalker AF; Holmes DJ; Holden D; et alRosenberg M; McDevitt D. (Feb 2001). Characterization of the Streptococcus pneumoniae NADH oxidase that is required for infection. Microbiology. 147:431-438.
  • Beuzón CR; Méresse S; Unsworth KE; Ruíz-Albert J; Garvis S; Waterman SR; Ryder TA; Boucrot E; et alHolden DW. (3 Jul 2000). Salmonella maintains the integrity of its intracellular vacuole through the action of SifA. EMBO J. 19:3235-3249. DOI.
  • Brown JS; Aufauvre-Brown A; Brown J; Jennings JM; Arst H; Holden DW. (Jun 2000). Signature-tagged and directed mutagenesis identify PABA synthetase as essential for Aspergillus fumigatus pathogenicity. Mol Microbiol. 36:1371-1380.
  • Unsworth KE; Holden DW. (29 May 2000). Identification and analysis of bacterial virulence genes in vivo. Philos Trans R Soc Lond B Biol Sci. 355:613-622. DOI.
  • Dorman CJ; Dougan G; Holden DW; Williams P; Smith H. (29 May 2000). The activities of bacterial pathogens in vivo - Preface. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES. 355:549-550. Author weblink.
  • Vazquez-Torres A; Xu YS; Jones-Carson J; Holden DW; Lucia SM; Dinauer MC; Mastroeni P; Fang FC. (3 Mar 2000). Salmonella pathogenicity island 2-dependent evasion of the phagocyte NADPH oxidase. SCIENCE. 287:1655-1658. Author weblink DOI.
  • Shea JE; Holden DW. (1 Jan 2000). Signature-tagged mutagenesis helps identify virulence genes. ASM NEWS. 66:15-20. Author weblink.
  • Chiang SL; Mekalanos JJ; Holden DW. (1 Jan 1999). In vivo genetic analysis of bacterial virulence. ANNUAL REVIEW OF MICROBIOLOGY. 53:129-154. Author weblink DOI.
  • Hensel M; Shea JE; Waterman SR; Mundy R; Nikolaus T; Banks G; Vazquez-Torres A; Gleeson C; et alFang FC; Holden DW. (1 Oct 1998). Genes encoding putative effector proteins of the type III secretion system of Salmonella pathogenicity island 2 are required for bacterial virulence and proliferation in macrophages. MOLECULAR MICROBIOLOGY. 30:163-174. Author weblink DOI.
  • Mei JM; Nourbakhsh F; Ford CW; Holden DW. (Oct 1997). Identification of Staphylococcus aureus virulence genes in a murine model of bacteraemia using signature-tagged mutagenesis. Mol Microbiol. 26:399-407.
  • Hensel M; Shea JE; Raupach B; Monack D; Falkow S; Gleeson C; Kubo T; Holden DW. (1 Apr 1997). Functional analysis of ssaJ and the ssaK/U operon, 13 genes encoding components of the type III secretion apparatus of Salmonella Pathogenicity Island 2. MOLECULAR MICROBIOLOGY. 24:155-167. Author weblink DOI.
  • Hensel M; Shea JE; Gleeson C; Jones MD; Dalton E; Holden DW. (21 Jul 1995). Simultaneous identification of bacterial virulence genes by negative selection. Science. 269:400-403.

Patents

  • Anti-bacterial methods & materials. Patent number: WO99/01473 (PCT-International Patent Application).
  • Identification of Genes. Published: 27 Jul 2000.
  • Identification of Genes. Published: 19 Dec 2000.
  • Identification of Genes. Published: 9 Oct 2001.
  • Identification of Genes. Published: 18 Jan 2001.
  • Identification of Genes. Published: 29 Jan 2002.
Share this on Delicious
Tweet this
Digg this
Stumble this
Share this on Facebook