Dr David J.P O'Callaghan

 

I graduated from Imperial College with both a BSc and a Medical degree in 2000. Since then I have continued my clinical training and become an SpR in both Anaesthesia and Intensive Care Medicine. Since August 2008 I have been registered as a PhD student at Imperial.

As part of my PhD we have constucted several in-vitro models of sepsis in which we have examined primary human monocyte response phenotypes with a specific focus on Tumour Necrosis Factor-alpha Converting Enzyme function. We have successsfully obtained funding from the Intensive Care Foundation to investigate response phentoypes within the context of critical illness and are currently actively recruiting patients from Imperial College Helathcare NHS Trust. We are hoping that the results of our work will lend us greater insight into monocyte function/dysfunction and may help identify future therapeutic targets.

My previous research experience was at the Royal Postgraduate Medical School where I spent time examining the structure, function and regulation of the human human apical calcium transporter within the small intestine.

 

Publications

Scott A, O’Dea KP, O’Callaghan D, et al. Reactive oxygen species and p38 MAPK mediate TNF-alpha converting enzyme (TACE/ADAM17) activation in primary human monocytes. J Biol Chem 2011; 280:41 35466-35476

Skipworth J, O’Callaghan D, et al. Acute Pancreatitis. British Journal of Intensive Care 2010; 20: 105-115

Skipworth J, Srilekha A, Raptis D, O’Callaghan D, et al. Combined Lumbar Spinal and Thoracic High-Epidural Regional Anesthesia as an Alternative to General Anesthesia for High-Risk Patients Undergoing Gastrointestinal and Colorectal Surgery. World Journal of Surgery 2009, 33: 9: 1809-1814

Barley NF, Howard A, O’Callaghan DJ et al. Epithelial calcium transporter in human duodenum. American Journal of Physiology 2001; 280: 285-290