Professor Dominic J Wells

Publications


Journals

  • Cirak S; Arechavala-Gomeza V; Guglieri M; Feng L; Torelli S; Anthony K; Abbs S; Garralda ME; et alBourke J; Wells DJ; Dickson G; Wood MJA; Wilton SD; Straub V; Kole R; Shrewsbury SB; Sewry C; Morgan JE; Bushby K; Muntoni F. (13 Aug 2011). Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-escalation study. LANCET. 378:595-605. Author weblink DOI.
  • Browning RJ; Mulvana H; Tang M; Hajnal JV; Wells DJ; Eckersley RJ. (1 Sep 2011). INFLUENCE OF NEEDLE GAUGE ON IN VIVO ULTRASOUND AND MICROBUBBLE-MEDIATED GENE TRANSFECTION. ULTRASOUND IN MEDICINE AND BIOLOGY. 37:1531-1537. Author weblink DOI.
  • Browning RJ; Mulvana H; Tang M; Hajnal JV; Wells DJ; Eckersley RJ. (Sep 2011). Influence of needle gauge on in vivo ultrasound and microbubble-mediated gene transfection. Ultrasound Med Biol. 37:1531-1537. DOI.
  • Song W; Dyer E; Stuckey D; Leung MC; Memo M; Mansfield C; Ferenczi M; Liu K; et alRedwood C; Nowak K; Harding S; Clarke K; Wells D; Marston S. (Sep 2010). Investigation of a transgenic mouse model of familial dilated cardiomyopathy. J Mol Cell Cardiol. 49:380-389. DOI.
  • Malerba A; Sharp PS; Graham IR; Arechavala-Gomeza V; Foster K; Muntoni F; Wells DJ; Dickson G. (1 Feb 2011). Chronic Systemic Therapy With Low-dose Morpholino Oligomers Ameliorates the Pathology and Normalizes Locomotor Behavior in mdx Mice. MOLECULAR THERAPY. 19:345-354. DOI.
  • Brockington M; Torelli S; Sharp PS; Liu K; Cirak S; Brown SC; Wells DJ; Muntoni F. (28 Dec 2010). Transgenic Overexpression of LARGE Induces alpha-Dystroglycan Hyperglycosylation in Skeletal and Cardiac Muscle. PLOS ONE. 5. Author weblink DOI.
  • Sharp PS; Bye-a-Jee H; Wells DJ. (Jan 2011). Physiological characterization of muscle strength with variable levels of dystrophin restoration in mdx mice following local antisense therapy. Mol Ther. 19:165-171. DOI.
  • van der Weerd L; Tariq Akbar M; Aron Badin R; Valentim LM; Thomas DL; Wells DJ; Latchman DS; Gadian DG; et alLythgoe MF; de Belleroche JS. (Apr 2010). Overexpression of heat shock protein 27 reduces cortical damage after cerebral ischemia. J Cereb Blood Flow Metab. 30:849-856. DOI.
  • Wells DJ. (Feb 2010). Electroporation and ultrasound enhanced non-viral gene delivery in vitro and in vivo. Cell Biol Toxicol. 26:21-28. DOI.
  • Rayner K; Sun J; Chen Y-X; McNulty M; Simard T; Zhao X; Wells DJ; de Belleroche J; et alO'Brien ER. (1 Nov 2009). Heat Shock Protein 27 Protects Against Atherogenesis via an Estrogen-Dependent Mechanism Role of Selective Estrogen Receptor Beta Modulation. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 29:1751-U90. Author weblink DOI.
  • Kinali M; Arechavala-Gomeza V; Feng L; Cirak S; Hunt D; Adkin C; Guglieri M; Ashton E; et alAbbs S; Nihoyannopoulos P; Garrolda ME; Rutherford M; Mcculley C; Popplewell L; Graham IR; Dickson G; Wood MJA; Wells DJ; Wilton SD; Kole R; Straub V; Bushby K; Sewry C; Morgan JE; Muntoni F. (1 Oct 2009). Local restoration of dystrophin expression with the morpholino oligomer AVI-4658 in Duchenne muscular dystrophy: a single-blind, placebo-controlled, dose-escalation, proof-of-concept study. LANCET NEUROLOGY. 8:918-928. Author weblink DOI.
  • Dai T; Patel-Chamberlin M; Natarajan R; Todorov I; Ma J; LaPage J; Phillips L; Nast CC; et alBecerra D; Chuang P; Tong L; de Belleroche J; Wells DJ; Wang Y; Adler SG. (Jul 2009). Heat shock protein 27 overexpression mitigates cytokine-induced islet apoptosis and streptozotocin-induced diabetes. Endocrinology. 150:3031-3039. DOI.
  • Alter J; Sennoga CA; Lopes DM; Eckersley RJ; Wells DJ. (Jun 2009). Microbubble stability is a major determinant of the efficiency of ultrasound and microbubble mediated in vivo gene transfer. Ultrasound Med Biol. 35:976-984. DOI.
  • Wells DJ. (2009). Gene doping: possibilities and practicalities. Med Sport Sci. 54:166-175. DOI.
  • Foster H; Sharp PS; Athanasopoulos T; Trollet C; Graham IR; Foster K; Wells DJ; Dickson G. (1 Nov 2008). Codon and mRNA Sequence Optimization of Microdystrophin Transgenes Improves Expression and Physiological Outcome in Dystrophic mdx Mice Following AAV2/8 Gene Transfer. MOLECULAR THERAPY. 16:1825-1832. Author weblink DOI.
  • Palazzoli F; Carnus E; Wells DJ; Bigot Y. (1 Oct 2008). Sustained Transgene Expression Using Non-Viral Enzymatic Systems for Stable Chromosomal Integration. CURRENT GENE THERAPY. 8:367-390. Author weblink DOI.
  • Wells DJ. (1 Sep 2008). Peptide-conjugated antisense therapy takes a skip ahead. MOLECULAR THERAPY. 16:1523-1524. Author weblink DOI.
  • Wells DJ. (1 Aug 2008). Increased treatment options for Duchenne and related muscular dystropies. GENE THERAPY. 15:1077-1078. Author weblink DOI.
  • Rayner K; Chen Y-X; McNulty M; Simard T; Zhao X; Wells DJ; de Belleroche J; O'Brien ER. (18 Jul 2008). Extracellular release of the atheroprotective heat shock protein 27 is mediated by estrogen and competitively inhibits acLDL binding to scavenger receptor-A. CIRCULATION RESEARCH. 103:133-141. Author weblink DOI.
  • Wells DJ. (Jun 2008). Gene doping: the hype and the reality. Br J Pharmacol. 154:623-631. DOI.
  • Sharp PS; Akbar MT; Bouri S; Senda A; Joshi K; Chen HJ; Latchman DS; Wells DJ; et alde Belleroche J. (Apr 2008). Protective effects of heat shock protein 27 in a model of ALS occur in the early stages of disease progression. Neurobiol Dis. 30:42-55. DOI.
  • Wells KE; McMahon J; Foster H; Ferrer A; Wells DJ. (2008). Gene delivery to dystrophic muscle. Methods Mol Biol. 423:421-431. DOI.
  • Zourlidou A; Gidalevitz T; Kristiansen M; Landles C; Woodman B; Wells DJ; Latchman DS; de Belleroche J; et alTabrizi SJ; Morimoto RI; Bates GP. (1 May 2007). Hsp27 overexpression in the R6/2 mouse model of Huntington's disease: chronic neurodegeneration does not induce Hsp27 activation. HUMAN MOLECULAR GENETICS. 16:1078-1090. Author weblink DOI.
  • Okkenhaug H; Weylandt K-H; Carmena D; Wells DJ; Higgins CF; Sardini A. (1 Nov 2006). The human ClC-4 protein, a member of the CLC chloride channel/transporter family, is localized to the endoplasmic reticulum by its N-terminus. FASEB JOURNAL. 20:2390-+. Author weblink DOI.
  • Hawkins P; Felton LM; van Loo P; Maconochie M; Wells DJ; Dennison N; Hubrecht R; Jennings M. (1 Oct 2006). Report of the 2005 RSPCA/UFAW rodent welfare group meeting. LAB ANIMAL. 35:29-+. Author weblink DOI.
  • Mollica LR; Crawley JT; Liu K; Rance JB; Cockerill PN; Follows GA; Landry JR; Wells DJ; et alLane DA. (15 Aug 2006). Role of a 5'-enhancer in the transcriptional regulation of the human endothelial cell protein C receptor gene. Blood. 108:1251-1259. DOI.
  • Davies JK; Wells DJ; Liu K; Whitrow HR; Daniel TD; Grignani R; Lygate CA; Schneider JE; et alNoël G; Watkins H; Carling D. (May 2006). Characterization of the role of gamma2 R531G mutation in AMP-activated protein kinase in cardiac hypertrophy and Wolff-Parkinson-White syndrome. Am J Physiol Heart Circ Physiol. 290:H1942-H1951. DOI.
  • Wells DJ; Playle LC; Enser WE; Flecknell PA; Gardiner MA; Holland J; Howard BR; Hubrecht R; et alHumphreys KR; Jackson IJ; Lane N; Maconochie M; Mason G; Morton DB; Raymond R; Robinson V; Smith JA; Watt N. (Apr 2006). Assessing the welfare of genetically altered mice. Lab Anim. 40:111-114. DOI.
  • Wells DJ. (Mar 2006). Viral and non-viral methods for gene transfer into skeletal muscle. Curr Opin Drug Discov Devel. 9:163-168.
  • Wells DJ. (2006). Therapeutic restoration of dystrophin expression in Duchenne muscular dystrophy. J Muscle Res Cell Motil. 27:387-398. DOI.
  • Wells DJ; Wells KE. (Dec 2005). What do animal models have to tell us regarding Duchenne muscular dystrophy?. Acta Myol. 24:172-180.
  • Antoniv TT; Tanaka S; Sudan B; De Val S; Liu K; Wang L; Wells DJ; Bou-Gharios G; et alRamirez F. (21 Oct 2005). Identification of a repressor in the first intron of the human alpha 2(I) collagen gene (COL1A2). JOURNAL OF BIOLOGICAL CHEMISTRY. 280:35417-35423. Author weblink DOI.
  • Dolatshad NF; Brockington M; Torelli S; Skordis L; Wever U; Wells DJ; Muntoni F; Brown SC. (1 Oct 2005). Mutated fukutin-related protein (FKRP) localises as wild type in differentiated muscle cells. Exp Cell Res. 309:370-378. DOI.
  • Henson SM; Snelgrove R; Hussell T; Wells DJ; Aspinall R. (15 Sep 2005). An IL-7 fusion protein that shows increased thymopoietic ability. J Immunol. 175:4112-4118.
  • Tanaka S; Antoniv TT; Liu K; Wang L; Wells DJ; Ramirez F; Bou-Gharios G. (31 Dec 2004). Cooperativity between far upstream enhancer and proximal promoter elements of the human {alpha}2(I) collagen (COL1A2) gene instructs tissue specificity in transgenic mice. J Biol Chem. 279:56024-56031. DOI.
  • Efthymiou CA; Mocanu MM; de Belleroche J; Wells DJ; Latchmann DS; Yellon DM. (Nov 2004). Heat shock protein 27 protects the heart against myocardial infarction. Basic Res Cardiol. 99:392-394. DOI.
  • Wells DJ. (Sep 2004). Gene therapy progress and prospects: electroporation and other physical methods. Gene Ther. 11:1363-1369. DOI.
  • Wells DJ. (Aug 2004). Opening the floodgates: clinically applicable hydrodynamic delivery of plasmid DNA to skeletal muscle. Mol Ther. 10:207-208. DOI.
  • Ferrer A; Foster H; Wells KE; Dickson G; Wells DJ. (Jun 2004). Long-term expression of full-length human dystrophin in transgenic mdx mice expressing internally deleted human dystrophins. Gene Ther. 11:884-893. DOI.
  • McMahon JM; Wells DJ. (2004). Electroporation for gene transfer to skeletal muscles: current status. BioDrugs. 18:155-165.
  • Wells KE; Fletcher S; Mann CJ; Wilton SD; Wells DJ. (25 Sep 2003). Enhanced in vivo delivery of antisense oligonucleotides to restore dystrophin expression in adult mdx mouse muscle. FEBS Lett. 552:145-149.
  • Robinson V; Morton DB; Anderson D; Carver JFA; Francis RJ; Hubrecht R; Jenkins E; Mathers KE; et alRaymond R; Rosewell I; Wallace J; Wells DJ. (1 Jul 2003). Refinement and reduction in production of genetically modified mice - Sixth report of the BVAAWF/FRAME/RSPCA/UFAW Joint Working Group on Refinement. LABORATORY ANIMALS. 37:S1-S51. Author weblink.
  • Bellingham J; Tarttelin EE; Foster RG; Wells DJ. (15 Jun 2003). Structure and evolution of the Teleost extraretinal rod-like opsin (errlo) and ocular rod opsin (rho) genes: Is Teleost rho a retrogene?. JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION. 297B:1-10. Author weblink DOI.
  • Akbar MT; Lundberg AM; Liu K; Vidyadaran S; Wells KE; Dolatshad H; Wynn S; Wells DJ; et alLatchman DS; de Belleroche J. (30 May 2003). The neuroprotective effects of heat shock protein 27 overexpression in transgenic animals against kainate-induced seizures and hippocampal cell death. J Biol Chem. 278:19956-19965. DOI.
  • Tarttelin EE; Bellingham J; Bibb LC; Foster RG; Hankins MW; Gregory-Evans K; Gregory-Evans CY; Wells DJ; et alLucas RJ. (Mar 2003). Expression of opsin genes early in ocular development of humans and mice. Exp Eye Res. 76:393-396.
  • Gollins H; McMahon J; Wells KE; Wells DJ. (Mar 2003). High-efficiency plasmid gene transfer into dystrophic muscle. Gene Ther. 10:504-512. DOI.
  • Bellingham J; Wells DJ; Foster RG. (24 Jan 2003). In silico characterisation and chromosomal localisation of human RRH (peropsin)--implications for opsin evolution. BMC Genomics. 4:3.
  • Wells KE; Torelli S; Lu Q; Brown SC; Partridge T; Muntoni F; Wells DJ. (Jan 2003). Relocalization of neuronal nitric oxide synthase (nNOS) as a marker for complete restoration of the dystrophin associated protein complex in skeletal muscle. Neuromuscul Disord. 13:21-31.
  • Robinson V; Morton DB; Anderson D; Carver JFA; Francis RJ; Hubrecht R; Jenkins E; Mathers K; et alRaymond R; Rosewell I; Wallace J; Wells DJ. (2003). Sixth report of the BVAAWF/FRAME/RSPCA/UFAW Joint Working Group on Refinement. Refinement and reduction in production of genetically modified mice. Laboratory Animal. 37.
  • Bellingham J; Whitmore D; Philp AR; Wells DJ; Foster RG. (15 Nov 2002). Zebrafish melanopsin: isolation, tissue localisation and phylogenetic position. Brain Res Mol Brain Res. 107:128-136.
  • Wells DJ; Ferrer A; Wells KE. (Nov 2002). Immunological hurdles in the path to gene therapy for Duchenne muscular dystrophy. Expert Rev Mol Med. 4:1-23. DOI.
  • Dickson G; Roberts ML; Wells DJ; Fabb SA. (Oct 2002). Recombinant micro-genes and dystrophin viral vectors. Neuromuscul Disord. 12 Suppl 1:S40-S44.
  • Wells DJ; Wells KE. (1 Oct 2002). Gene transfer studies in animals: what do they really tell us about the prospects for gene therapy in DMD?. NEUROMUSCULAR DISORDERS. 12:S11-S22. Author weblink DOI.
  • Roberts ML; Wells DJ; Graham IR; Fabb SA; Hill VJ; Duisit G; Yuasa K; Takeda S; et alCosset FL; Dickson G. (15 Jul 2002). Stable micro-dystrophin gene transfer using an integrating adeno-retroviral hybrid vector ameliorates the dystrophic pathology in mdx mouse muscle. Hum Mol Genet. 11:1719-1730.
  • Fabb SA; Wells DJ; Serpente P; Dickson G. (1 Apr 2002). Adeno-associated virus vector gene transfer and sarcolemmal expression of a 144 kDa micro-dystrophin effectively restores the dystrophin-associated protein complex and inhibits myofibre degeneration in nude/mdx mice. Hum Mol Genet. 11:733-741.
  • De Val S; Ponticos M; Antoniv TT; Wells DJ; Abraham D; Partridge T; Bou-Gharios G. (15 Mar 2002). Identification of the key regions within the mouse pro-alpha 2(I) collagen gene far-upstream enhancer. J Biol Chem. 277:9286-9292. DOI.
  • Akbar MT; Wells DJ; Latchman DS; de Belleroche J. (30 Sep 2001). Heat shock protein 27 shows a distinctive widespread spatial and temporal pattern of induction in CNS glial and neuronal cells compared to heat shock protein 70 and caspase 3 following kainate administration. Brain Res Mol Brain Res. 93:148-163.
  • McMahon JM; Signori E; Wells KE; Fazio VM; Wells DJ. (Aug 2001). Optimisation of electrotransfer of plasmid into skeletal muscle by pretreatment with hyaluronidase -- increased expression with reduced muscle damage. Gene Ther. 8:1264-1270. DOI.
  • Schaeffer PJ; Hokanson JF; Wells DJ; Lindstedt SL. (Jan 2001). Cold exposure increases running VO(2max) and cost of transport in goats. Am J Physiol Regul Integr Comp Physiol. 280:R42-R47.
  • Ferrer A; Wells KE; Wells DJ. (Sep 2000). Immune responses to dystropin: implications for gene therapy of Duchenne muscular dystrophy. Gene Ther. 7:1439-1446. DOI.
  • Eriksson M; Ansved T; Edstrom L; Wells DJ; Watt DJ; Anvret M; Carey N. (30 Jun 2000). Independent regulation of the myotonic dystrophy 1 locus genes postnatally and during adult skeletal muscle regenerator. JOURNAL OF BIOLOGICAL CHEMISTRY. 275:19964-19969. Author weblink DOI.
  • Walsh FS; Hobbs C; Wells DJ; Slater CR; Fazeli S. (1 Mar 2000). Ectopic expression of NCAM in skeletal muscle of transgenic mice results in terminal sprouting at the neuromuscular junction and altered structure but not function. MOLECULAR AND CELLULAR NEUROSCIENCE. 15:244-261. Author weblink DOI.
  • Tsukamoto H; Wells DJ; Brown SC; Serpente P; Strong PN; Drew J; Inui K; Okada S; et alDickson G. (1 Jul 1999). Enhanced expression of recombinant dystrophin following intramuscular injection of Epstein-Barr virus (EBV)-based mini-chromosome vectors in mdx mice. GENE THERAPY. 6:1331-1335. Author weblink DOI.
  • Bou-Gharios G; Wells DJ; Lu QL; Morgan JE; Partridge T. (Jun 1999). Differential expression and secretion of alpha 1 anti-trypsin between direct DNA injection and implantation of transfected myoblast. Gene Ther. 6:1021-1029. DOI.
  • Fassati A; Bardoni A; Sironi M; Wells DJ; Bresolin N; Scarlato G; Hatanaka M; Yamaoka S; et alDickson G. (20 Nov 1998). Insertion of two independent enhancers in the long terminal repeat of a self-inactivating vector results in high-titer retroviral vectors with tissue-specific expression. HUMAN GENE THERAPY. 9:2459-2468. Author weblink DOI.
  • McMahon JM; Wells KE; Bamfo JE; Cartwright MA; Wells DJ. (Sep 1998). Inflammatory responses following direct injection of plasmid DNA into skeletal muscle. Gene Ther. 5:1283-1290. DOI.
  • Wells DJ; Maule J; McMahon J; Mitchell R; Damien E; Poole A; Wells KE. (Jun 1998). Evaluation of plasmid DNA for in vivo gene therapy: factors affecting the number of transfected fibers. J Pharm Sci. 87:763-768. DOI.
  • Fassati A; Wells DJ; Serpente PAS; Walsh FS; Brown SC; Strong PN; Dickson G. (1 Aug 1997). Genetic correction of dystrophin deficiency and skeletal muscle remodeling in adult MDX mouse via transplantation of retroviral producer cells. JOURNAL OF CLINICAL INVESTIGATION. 100:620-628. Author weblink DOI.
  • Heath SK; Carne S; Hoyle C; Johnson KJ; Wells DJ. (May 1997). Characterisation of expression of mDMAHP, a homeodomain-encoding gene at the murine DM locus. Hum Mol Genet. 6:651-657.
  • Wells KE; Maule J; Kingston R; Foster K; McMahon J; Damien E; Poole A; Wells DJ. (28 Apr 1997). Immune responses, not promoter inactivation, are responsible for decreased long-term expression following plasmid gene transfer into skeletal muscle. FEBS Lett. 407:164-168.

Conferences

  • Terry RL; Hasan N; Wells DJ. mdx Mice Show Changes in Muscle Fiber Profile Number with Age. 7th Annual Conference of the British-Society-for-Gene-Therapy, 29 Mar 2010 - 31 Mar 2010. 21:516-516. MARY ANN LIEBERT INC (1 Apr 2010).
  • Ma X; McNulty M; Wells DJ; de Belleroche JS; O'Brien ER. Over-expression of Heat Shock Protein 27 Accelerates Re-endothelialization and Attenuates Neointimal Formation Post-Arterial Injury. 82nd Scientific Session of the American-Heart-Association, 14 Nov 2009 - 18 Nov 2009. 120:S951-S951. LIPPINCOTT WILLIAMS & WILKINS (3 Nov 2009).
  • Kinali M; Arechavala-Gomeza V; Feng L; Cirak S; Hunt D; Adkin C; Guglieri M; Abbs S; et alNihoyannopoulos P; Garralda ME; Rutherford M; McCulley C; Popplewell L; Graham IR; Dickson G; Wood MJA; Wells DJ; Wilton SD; Holt T; Kole R; Straub V; Bushby K; Sewry C; Morgan JE; Muntoni F. Restoration of dystrophin expression in Duchenne muscular dystrophy: A single blind, placebo-controlled dose escalation study using morpholino oligomer AVI-4658. 14th International Congress of the World-Muscle-Society, 9 Sep 2009 - 12 Sep 2009. 19:659-659. PERGAMON-ELSEVIER SCIENCE LTD (1 Sep 2009). Author weblink DOI.
  • Relvas JB; Aldridge H; Wells KE; Wells DJ; Watt DJ. Exogenous genes are expressed in mdx muscle fibres following the implantation of primary mouse skin cells. Symposium on Myoblast Transplantation at the 3rd International Congress of the Cell-Transplant-Society, 1996. 7:211-219. UNIPRESS PADOVA (1 Jan 1997). Author weblink.
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