Dr David J Coe

In 2001, I gained a Bsc in Biochemistry from ImperialCollege,London. In 2002-3 I studied at Nottingham Trent University and Tubingen Univesity to gain an Msc in Biomedical Science. In November of 2003 I joined the Transplantation Biology group as a research assistant. I moved with the group when they joined Imperial College on the same campus in 2005. In 2007 I started a PhD in Tumour Immunology which I completed in March, 2011.

Throughout my time working with Dr. Jian-Guo Chai in the Transplantation Biology Group we have used the HY system of transplantation tolerence to study the interactions between T cells and grafted tissues and later between T cells and tumours.

Publications :

Arginine depletion as a mechanism for the immune privilege of corneal allografts. Fu H, Khan A, Coe D, Zaher S, Chai JG, Kropf P, Muller I, Larkin DF, George AJ. Eur J Immunol. 2011, Jul 29. [Epub ahead of print].

Molecular mechanisms of induction of antigen-specific allograft tolerance by intranasal peptide administration. Derbyshire K, Addey C, Coe D, Stuckey DW, Muezzin H, Bubier JA, Shaffer DJ, Roopenian DC, Chai JG, Scott DM. J Immunol. 2011; 186: 5719-28.

Functional plasticity of antigen-specific regulatory T cells in context of tumor. Addey C, White M, Dou L, Coe D, Dyson J, Chai JG. J Immunol. 2011; 186: 4557-64

Ig gene-like molecule CD31 plays a nonredundant role in the regulation of T-cell immunity and tolerance. Ma L, Mauro C, Cornish GH, Chai JG, Coe D, Fu H, Patton D, Okkenhaug K, Franzoso G, Dyson J, Nourshargh S, Marelli-Berg FM. PNAS. 2010; 107: 19461-6.

The roles of antigen-specificity, responsiveness to transforming growth factor-β and antigen-presenting cell subsets in tumour-induced expansion of regulatory T cells. Coe D, Addey C, White M, Simpson E, Dyson J, Chai JG. Immunology. 2010; 131: 556-69.

Depletion of regulatory T cells by anti-GITR mAb as a novel mechanism for cancer immunotherapy. Coe D, Begom S, Addey C, White M, Dyson J, Chai JG. Cancer Immunol Immunother. 2010; 59: 1367-77

Mice lacking C1q or C3 show accelerated rejection of minor H disparate skin grafts and resistance to induction of tolerance. Baruah P, Simpson E, Dumitriu IE, Derbyshire K, Coe D, Addey C, Dyson J, Chai JG, Cook T, Scott D, Botto M. Eur J Immunol. 2010; 40: 1758-67

In vitro expansion improves in vivo regulation by CD4+CD25+ Regulatory T cells. Chai JG, Coe D, Chen D, Simpson E, Dyson J, Scott D. J Immunol. 2008; 180: 858-869

Regulatory T cells, Derived from Naïve CD4+CD25- T Cells by In Vitro Foxp3 Gene Transfer, can Induce Transplantation Tolerance. Chai JG, Xue SA, Coe D, Addey C, Bartok I, Scott D, Simpson E, Stauss HJ, Hori S, Sakaguchi S, Dyson J. Transplantation. 2005; 79 : 1310-1316