Dr Emmanuel Dupont

Publications


Journals

  • Kreuzberg MM; Liebermann M; Segschneider S; Dobrowolski R; Dobrzynski H; Kaba R; Rowlinson G; Dupont E; et alSevers NJ; Willecke K. (1 Apr 2009). Human connexin31.9, unlike its orthologous protein connexin30.2 in the mouse, is not detectable in the human cardiac conduction system. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 46:553-559. Author weblink DOI.
  • Severs NJ; Bruce AF; Dupont E; Rothery S. (1 Oct 2008). Remodelling of gap junctions and connexin expression in diseased myocardium. CARDIOVASCULAR RESEARCH. 80:9-19. Author weblink DOI.
  • Grikscheit K; Thomas N; Bruce AF; Rothery S; Chan J; Severs NJ; Dupont E. (May 2008). Coexpression of connexin 45 with connexin 43 decreases gap junction size. Cell Commun Adhes. 15:185-193. DOI.
  • Desplantez T; Dupont E; Severs NJ; Weingart R. (1 Aug 2007). Gap junction channels and cardiac impulse propagation. JOURNAL OF MEMBRANE BIOLOGY. 218:13-28. Author weblink DOI.
  • Bruce AF; Rothery S; Dupont E; Severs NJ. (1 Mar 2008). Gap junction remodelling in human heart failure is associated with increased interaction of connexin43 with ZO-1. Cardiovasc Res. 77:757-765. DOI.
  • Matsushita T; Rama A; Charolidi N; Dupont E; Severs NJ. (1 Oct 2007). Relationship of connexin43 expression to phenotypic modulation in cultured human aortic smooth muscle cells. EUROPEAN JOURNAL OF CELL BIOLOGY. 86:617-628. Author weblink DOI.
  • Kaba R; Coppen SR; Dupont E; Skepper JN; Elneil S; Haw M; Pepper J; Yacoub M; et alRothery S; Severs NJ. (2002). Comparison of connexin43, 40 and 45 expression patterns in the developing human and mouse hearts. Cell Commun Adhes. 8:339-343.
  • Kanagaratnam P; Dupont E; Rothery S; Coppen S; Severs NJ; Peters NS. (May 2006). Human atrial conduction and arrhythmogenesis correlates with conformational exposure of specific epitopes on the connexin40 carboxyl tail. J Mol Cell Cardiol. 40:675-687. DOI.
  • Yeh HI; Lupu F; Dupont E; Severs NJ. (1 Nov 1997). Upregulation of connexin43 gap junctions between smooth muscle cells after balloon catheter injury in the rat carotid artery. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 17:3174-3184. Author weblink.
  • Ko YS; Yeh HI; Rothery S; Dupont E; Coppen SR; Severs NJ. (1 May 1999). Connexin make-up of endothelial gap junctions in the rat pulmonary artery as revealed by immunoconfocal microscopy and triple-label immunogold electron microscopy. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY. 47:683-691. Author weblink.
  • Ko YS; Yeh HI; Haw M; Dupont E; Kaba R; Plenz G; Robenek H; Severs NJ. (1 Jul 1999). Differential expression of connexin43 and desmin defines two subpopulations of medial smooth muscle cells in the human internal mammary artery. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 19:1669-1680. Author weblink.
  • Severs NJ; Dupont E; Thomas N; Kaba R; Rothery S; Jain R; Sharpey K; Fry CH. (2006). Alterations in cardiac connexin expression in cardiomyopathies. Adv Cardiol. 42:228-242. DOI.
  • Yeh HI; Rothery S; Dupont E; Coppen SR; Severs NJ. (14 Dec 1998). Individual gap junction plaques contain multiple connexins in arterial endothelium. Circ Res. 83:1248-1263.
  • Uzumcu A; Norgett EE; Dindar A; Uyguner O; Nisli K; Kayserili H; Sahin SE; Dupont E; et alSevers NJ; Leigh IM; Yuksel-Apak M; Kelsell DP; Wollnik B. (1 Feb 2006). Loss of desmoplakin isoform I causes early onset cardiomyopathy and heart failure in a Naxos-like syndrome. JOURNAL OF MEDICAL GENETICS. 43. Author weblink DOI.
  • Tribulova N; Dupont E; Soukup T; Okruhlicova L; Severs NJ. (1 Jan 2005). Sex differences in connexin-43 expression in left ventricles of aging rats. PHYSIOLOGICAL RESEARCH. 54:705-708. Author weblink.
  • Yeh HI; Dupont E; Coppen S; Rothery S; Severs NJ. (1 Apr 1997). Gap junction localization and connexin expression in cytochemically identified endothelial cells of arterial tissue. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY. 45:539-550. Author weblink.
  • Kaba RA; Dupont E; Matsushita T; Coppen SR; Yacoub MH; Severs NJ. (6 Mar 2002). Connexin40 mRNA and protein expression is elevated in end-stage human ischemic heart disease. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 39:283A-283A. Author weblink.
  • Kaba RA; Coppen SR; Dupont E; Skepper JN; Elneil S; Yacoub MH; Rothery S; Severs NJ. (6 Mar 2002). Distinct expression patterns of connexins in the chambers and conduction system of the human fetal heart. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 39:229A-229A. Author weblink.
  • Desplantez T; Halliday D; Dupont E; Weingart R. (1 Jul 2004). Cardiac connexins Cx43 and Cx45: formation of diverse gap junction channels with diverse electrical properties. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY. 448:363-375. Author weblink DOI.
  • Severs NJ; Coppen SR; Dupont E; Yeh HI; Ko YS; Matsushita T. (1 May 2004). Gap junction alterations in human cardiac disease. Cardiovasc Res. 62:368-377. DOI.
  • Severs NJ; Dupont E; Coppen SR; Halliday D; Inett E; Baylis D; Rothery S. (23 Mar 2004). Remodelling of gap junctions and connexin expression in heart disease. Biochim Biophys Acta. 1662:138-148. DOI.
  • Sui GP; Coppen SR; Dupont E; Rothery S; Gillespie J; Newgreen D; Severs NJ; Fry CH. (Aug 2003). Impedance measurements and connexin expression in human detrusor muscle from stable and unstable bladders. BJU Int. 92:297-305.
  • Halliday D; Dupont E; Coppen SR; Severs NJ. (Jul 2003). Development of a cell model for functional and structural analysis of connexin co-expression: achieving homogeneous and inducible expression of multiple connexins in stable transfectants. Cell Commun Adhes. 10:311-317.
  • Coppen SR; Kaba RA; Halliday D; Dupont E; Skepper JN; Elneil S; Severs NJ. (Jan 2003). Comparison of connexin expression patterns in the developing mouse heart and human foetal heart. Mol Cell Biochem. 242:121-127.
  • Yeh HI; Hou SH; Hu HR; Lee YN; Li JY; Dupont E; Coppen SR; Ko YS; et alSevers NJ; Tsai CH. (Dec 2002). Alteration of gap junctions and connexins in the right atrial appendage during cardiopulmonary bypass. J Thorac Cardiovasc Surg. 124:1106-1112. DOI.
  • Sui GP; Rothery S; Dupont E; Fry CH; Severs NJ. (Jul 2002). Gap junctions and connexin expression in human suburothelial interstitial cells. BJU Int. 90:118-129.
  • Coppen SR; Dupont E; Severs NJ. (Mar 2002). Re: The sinoatrial node, connexin distribution patterns and specific immunodetection of connexin45. Cardiovasc Res. 53:1043-1045.
  • Kaba RA; Skepper JN; Coppen SR; Dupont E; Severs NJ; Elneil S. (1 Sep 2001). Mapping connexins 45, 43 and 40 in the human foetal heart. EUROPEAN HEART JOURNAL. 22:56-56. Author weblink.
  • Kilarski WM; Rothery S; Roomans GM; Ulmsten U; Rezapour M; Stevenson S; Coppen SR; Dupont E; et alSevers NJ. (15 Jul 2001). Multiple connexins localized to individual gap-junctional plaques in human myometrial smooth muscle. Microsc Res Tech. 54:114-122. DOI.
  • Ko YS; Coppen SR; Dupont E; Rothery S; Severs NJ. (Mar 2001). Regional differentiation of desmin, connexin43, and connexin45 expression patterns in rat aortic smooth muscle. Arterioscler Thromb Vasc Biol. 21:355-364.
  • Dupont E; Ko Y; Rothery S; Coppen SR; Baghai M; Haw M; Severs NJ. (13 Feb 2001). The gap-junctional protein connexin40 is elevated in patients susceptible to postoperative atrial fibrillation. Circulation. 103:842-849.
  • Dupont E; Matsushita T; Kaba RA; Vozzi C; Coppen SR; Khan N; Kaprielian R; Yacoub MH; et alSevers NJ. (Feb 2001). Altered connexin expression in human congestive heart failure. J Mol Cell Cardiol. 33:359-371. DOI.
  • Severs NJ; Rothery S; Dupont E; Coppen SR; Yeh HI; Ko YS; Matsushita T; Kaba R; et alHalliday D. (1 Feb 2001). Immunocytochemical analysis of connexin expression in the healthy and diseased cardiovascular system. Microsc Res Tech. 52:301-322. DOI.
  • Kaba RA; Coppen SR; Dupont E; Skepper JN; Elneil S; Haw MP; Pepper JR; Yacoub MH; et alRothery S; Severs NJ. (2001). Comparison of connexin 43, 40 and 45 expression patterns in the developing human and mouse hearts. Cell Commun Adhes. 8:339-343.
  • Duthe F; Dupont E; Verrecchia F; Plaisance I; Severs NJ; Sarrouilhe D; Herve JC. (1 Dec 2000). Dephosphorylation agents depress gap junctional communication between rat cardiac cells without modifying the connexin43 phosphorylation degree. GENERAL PHYSIOLOGY AND BIOPHYSICS. 19:441-449. Author weblink.
  • Dupont E; Matsushita T; Vozzi C; Khan N; Coppen SR; Yacoub MH; Severs NJ. (31 Oct 2000). Altered connexin mRNA and protein expression in human congestive heart failure. CIRCULATION. 102:595-595. Author weblink.
  • Dupont E; Khan N; Matsushita T; Coppen SR; Yacoub M; Severs NJ. (1 Aug 2000). Altered connexin mRNA and protein expression in human congestive heart failure. EUROPEAN HEART JOURNAL. 21:251-251. Author weblink.
  • Vozzi C; Dupont E; Coppen SR; Yeh HI; Severs NJ. (May 1999). Chamber-related differences in connexin expression in the human heart. J Mol Cell Cardiol. 31:991-1003. DOI.
  • Kaprielian RR; Gunning M; Dupont E; Sheppard MN; Rothery SM; Underwood R; Pennell DJ; Fox K; et alPepper J; Poole-Wilson PA; Severs NJ. (24 Feb 1998). Downregulation of immunodetectable connexin43 and decreased gap junction size in the pathogenesis of chronic hibernation in the human left ventricle. Circulation. 97:651-660.
  • Coppen SR; Dupont E; Rothery S; Severs NJ. (9 Feb 1998). Connexin45 expression is preferentially associated with the ventricular conduction system in mouse and rat heart. Circ Res. 82:232-243.
  • Kilarski WM; Dupont E; Coppen S; Yeh HI; Vozzi C; Gourdie RG; Rezapour M; Ulmsten U; et alRoomans GM; Severs NJ. (1 Jan 1998). Identification of two further gap-junctional proteins, connexin40 and connexin45, in human myometrial smooth muscle cells at term. EUROPEAN JOURNAL OF CELL BIOLOGY. 75:1-8. Author weblink.
  • Kaprielian RR; Dupont E; Hafizi S; Poole-Wilson PA; Khaghani A; Yacoub MH; Severs NJ. (Aug 1997). Angiotensin II receptor type 1 mRNA is upregulated in atria of patients with end-stage heart failure. J Mol Cell Cardiol. 29:2299-2304. DOI.
  • Kaprielian RR; Dupont E; Gunning M; Underwood R; Pennell DJ; Sheppard MN; Fox KM; Pepper J; et alPooleWilson PA; Severs NJ. (15 Oct 1996). Cell structure and connexin43 distribution in hibernating ventricular myocardium. CIRCULATION. 94:1082-1082. Author weblink.

Conferences

  • Ko YS; Yey HI; Rothery S; Dupont E; Severs NJ. Simultaneous localization of connexins 40, 37 and 43 in pulmonary artery endothelial gap junctions. 8th International Gap Junction Conference, 12 Jul 1997 - 17 Jul 1997. 183-187. I O S PRESS (1 Jan 1998). Author weblink.
  • Rowlinson G; Dupont E; Daubeney P; Severs NJ. Connexin40 is expressed in the right ventricles of patients with congenital heart malformations. 28th Annual Meeting of the European Section of the International-Society-for-Heart-Research. 44:733-733. (Apr 2008).
  • Grikscheit K; Bruce AF; Dupont E; Thomas N; Severs NJ. Increased expression of connexin45, as found in human heart failure, decreases gap junction size. 28th Annual Meeting of the European Section of the International-Society-for-Heart-Research. 44:732-733. (Apr 2008).
  • Kaba RA; Coppen SR; Dupont E; De Souza AC; Pepper JR; Severs NJ. Connexin 43 expression is elevated in human chronic atrial fibrillation related to coronary heart disease. 52nd Annual Scientific Session of the American-College-of-Cardiology. 41:274A-274A. (19 Mar 2003).
  • Thomas N; Dupont E; Halliday D; Fry CH; Severs NJ. An inducible cell system to investigate connexin co-expression and action potential propagation within the heart. 28th Annual International-Society-for-Heart-Research North American Section Meeting, 13 Jun 2006 - 16 Jun 2006. 40:984-984. ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD (1 Jun 2006). Author weblink DOI.
  • Dupont E. Gap junction remodeling in heart failure. 24th Annual Scientific Sessions of the European-Section of the International-Society-for-Heart-Research, 2 Jun 2004 - 6 Jun 2004. 36:726-726. ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD (1 May 2004). Author weblink.
  • Kaba RA; Yacoub MH; Dupont E; Elneil S; Skepper J; Coppen SR; Pepper JR; Severs NJ. Gap junctions in the atrio-ventricular conduction axis of the human heart. Congress of the European-Society-of-Cardiology, 30 Aug 2003 - 3 Sep 2003. 24:505-505. W B SAUNDERS CO LTD (1 Aug 2003). Author weblink DOI.
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