Dr. Ernesto Yagüe

Drug Resistance Group

My research interests centre on:

1. Molecular mechanisms of resistance to cancer chemotherapy  

• drug transporters, such as P-glycoprotein
• DNA damage response and p53

2. Control of drug-induced cell fate decissions: apoptosis, proliferation, senescence

3. Translational  control and drug resistance

• escape from stress granule sequestration and translational repression
• microRNAs and drug resistance

 Group page

Teaching

I organize the MRes in Cancer Biology, supervise several PhD and post-graduate students and collaborate in the Faculty of Medicine undergraduate teaching and tutoring.

Other academic activities

• I organize every two years the Drug Resistance Workshop, a forum for both clinicians and scientists to discuss the lastest developments in the field.
• I am member of the British Association for Cancer Research, Biochemical Society and Fellow of The Higher Education Academy.

Biography 

I obtained the degree of Doctor in Biology by the Complutense University (Madrid). After post-doctoral positions at the Pasteur Institute (Paris),  King's College (London) and in the biotech industry,  I joined Prof. Christopher Higgins'  laboratory at the Medical Research Council as a senior research scientist working on drug resistance. I moved to Imperial College in October 2007.