Professor Kian Fan Chung MD DSc FRCP

Publications


Journals

  • Chung KF. (Dec 2011). Prof. John Guy Widdicombe, 1925-2011: an appreciation of an eminent respiratory physiologist. EUR RESPIR J. 38:1243-1244. DOI.
  • Chung KF. (Jan 2012). Inflammatory biomarkers in severe asthma. Curr Opin Pulm Med. 18:35-41. DOI.
  • Bel EH; Sousa A; Fleming L; Bush A; Chung KF; Versnel J; Wagener AH; Wagers SS; et alSterk PJ; Compton CH; Unbiased Biomarkers Prediction. (Oct 2011). Diagnosis and definition of severe refractory asthma: an international consensus statement from the Innovative Medicine Initiative (IMI). THORAX. 66:910-917. DOI.
  • Kirkham PA; Caramori G; Casolari P; Papi AA; Edwards M; Shamji B; Triantaphyllopoulos K; Hussain F; et alPinart M; Khan Y; Heinemann L; Stevens L; Yeadon M; Barnes PJ; Chung KF; Adcock IM. (1 Oct 2011). Oxidative stress-induced antibodies to carbonyl-modified protein correlate with severity of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 184:796-802. DOI.
  • Torgerson DG; Ampleford EJ; Chiu GY; Gauderman WJ; Gignoux CR; Graves PE; Himes BE; Levin AM; et alMathias RA; Hancock DB; Baurley JW; Eng C; Stern DA; Celedon JC; Rafaels N; Capurso D; Conti DV; Roth LA; Soto-Quiros M; Togias A; Li XN; Myers RA; Romieu I; Van Den Berg DJ; Hu DL; Hansel NN; Hernandez RD; Israel E; Salam MT; Galanter J; Avila PC; Avila L; Rodriquez-Santana JR; Chapela R; Rodriguez-Cintron W; Diette GB; Adkinson NF; Abel RA; Ross KD; Shi M; Faruque MU; Dunston GM; Watson HR; Mantese VJ; Ezurum SC; Liang LM; Ruczinski I; Ford JG; Huntsman S; Chung KF; Vora H; Li X; Calhoun WJ; Castro M; Sienra-Monge JJ; del Rio-Navarro B; Deichmann KA; Heinzmann A; Wenzel SE; Busse WW; Gern JE; Lemanske RF; Beaty TH; Bleecker ER; Raby BA; Meyers DA; London SJ; Gilliland FD; Burchard EG; Martinez FD; Weiss ST; Williams LK; Barnes KC; Ober C; Nicolae DL; Mexico City Childhood Asthma; Childrens Hlth Study; HARBORS Study; Study Genes Environm Admixture; Study African Amer Asthma; CARE Network; CAMP; SAPPHIRE; GRAAD Study. (Sep 2011). Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. NAT GENET. 43:887-U103. DOI.
  • Mumby S; Chung KF; McCreanor JE; Moloney ED; Griffiths MJD; Quinlan GJ. (Sep 2011). Pro-oxidant iron in exhaled breath condensate: A potential excretory mechanism. RESP MED. 105:1290-1295. DOI.
  • Chung KF; Zhang J; Zhong N. (Oct 2011). Outdoor air pollution and respiratory health in Asia. Respirology. 16:1023-1026. DOI.
  • Caramori G; Lasagna L; Casalini AG; Adcock IM; Casolari P; Contoli M; Tafuro F; Padovani A; et alChung KF; Barnes PJ; Papi A; Rindi G; Bertorelli G. (28 Jul 2011). Immune Response to Mycobacterium tuberculosis Infection in the Parietal Pleura of Patients with Tuberculous Pleurisy. PLOS ONE. 6. DOI.
  • Michaeloudes C; Chang PJ; Petrou M; Chung KF. (15 Oct 2011). Transforming growth factor-β and nuclear factor E2–related factor 2 regulate antioxidant responses in airway smooth muscle cells: role in asthma. Am J Respir Crit Care Med. 184:894-903. DOI.
  • Li XN; Howard TD; Moore WC; Ampleford EJ; Li HS; Busse WW; Calhoun WJ; Castro M; et alChung KF; Erzurum SC; Fitzpatrick AM; Gaston B; Israel E; Jarjour NN; Teague WG; Wenzel SE; Peters SP; Hawkins GA; Bleecker ER; Meyers DA. (Jun 2011). Importance of hedgehog interacting protein and other lung function genes in asthma. J ALLERGY CLIN IMMUN. 127:1457-1465. DOI.
  • Kirkham PA; Caramori G; Casolari P; Papi A; Edwards M; Shamji B; Triantaphyllopoulos K; Hussain F; et alPinart M; Khan Y; Heinemann L; Stevens L; Yeadon M; Barnes PJ; Chung KF; Adcock IM. (16 Jun 2011). Oxidative Stress-induced Antibodies to Carbonyl-modified Protein Correlate with Severity of COPD. Am J Respir Crit Care Med. DOI.
  • Chung KF. (Jun 2011). p38 mitogen-activated protein kinase pathways in asthma and COPD. Chest. 139:1470-1479. DOI.
  • Caramori G; Adcock IM; Casolari P; Ito K; Jazrawi E; Tsaprouni L; Villetti G; Civelli M; et alCarnini C; Chung KF; Barnes PJ; Papi A. (Jun 2011). Unbalanced oxidant-induced DNA damage and repair in COPD: a link towards lung cancer. THORAX. 66:521-527. DOI.
  • Comhair SAA; Gaston BM; Ricci KS; Hammel J; Dweik RA; Teague WG; Meyers D; Ampleford EJ; et alBleecker ER; Busse WW; Calhoun WJ; Castro M; Chung KF; Curran-Everett D; Israel E; Jarjour WN; Moore W; Peters SP; Wenzel S; Hazen SL; Erzurum SC; Natl Heart Lung Blood Inst Severe. (4 May 2011). Detrimental Effects of Environmental Tobacco Smoke in Relation to Asthma Severity. PLOS ONE. 6. DOI.
  • Chung KF; Canning B; Macgarvey L. (2011). COUGH: consolidating a mature field for the next 5 years. Cough. 7:1. DOI.
  • Triantaphyllopoulos K; Hussain F; Pinart M; Zhang M; Li F; Adcock I; Kirkham P; Zhu J; et alChung KF. (May 2011). A model of chronic inflammation and pulmonary emphysema after multiple ozone exposures in mice. Am J Physiol Lung Cell Mol Physiol. 300:L691-L700. DOI.
  • Mumby S; Chung KF; McCreanor JE; Moloney ED; Griffiths MJ; Quinlan GJ. (Sep 2011). Pro-oxidant iron in exhaled breath condensate: a potential excretory mechanism. Respir Med. 105:1290-1295. DOI.
  • Li F; Zhang M; Hussain F; Triantaphyllopoulos K; Clark AR; Bhavsar PK; Zhou X; Chung KF. (Apr 2011). Inhibition of p38 MAPK-dependent bronchial contraction after ozone by corticosteroids. Eur Respir J. 37:933-942. DOI.
  • Worth H; Chung KF; Felser JM; Hu HL; Rueegg P. (Apr 2011). Cardio- and cerebrovascular safety of indacaterol vs formoterol, salmeterol, tiotropium and placebo in COPD. RESP MED. 105:571-579. DOI.
  • Liu L; Teague WG; Erzurum S; Fitzpatrick A; Mantri S; Dweik RA; Bleecker ER; Meyers D; et alBusse WW; Calhoun WJ; Castro M; Chung KF; Curran-Everett D; Israel E; Jarjour WN; Moore W; Peters SP; Wenzel S; Hunt JF; Gaston B; Natl Heart Lung Blood Inst. (Feb 2011). Determinants of Exhaled Breath Condensate pH in a Large Population With Asthma. CHEST. 139:328-336. DOI.
  • Jouneau S; Khorasani N; DE Souza P; Macedo P; Zhu J; Bhavsar PK; Chung KF. (May 2011). EMMPRIN (CD147) regulation of MMP-9 in bronchial epithelial cells in COPD. Respirology. 16:705-712. DOI.
  • Hui CK; Chung KF. (Feb 2011). Indacaterol: pharmacologic profile, efficacy and safety in the treatment of adults with COPD. Expert Rev Respir Med. 5:9-16. DOI.
  • Perry MM; Hui CK; Whiteman M; Wood ME; Adcock I; Kirkham P; Michaeloudes C; Chung KF. (Oct 2011). Hydrogen sulfide inhibits proliferation and release of IL-8 from human airway smooth muscle cells. Am J Respir Cell Mol Biol. 45:746-752. DOI.
  • Chung KF. (Jun 2011). Chronic 'cough hypersensitivity syndrome': a more precise label for chronic cough. Pulm Pharmacol Ther. 24:267-271. DOI.
  • Chung KF; Widdicombe J. (Jun 2011). The Sixth 2010 London International Symposium on Cough: A translational approach. Pulm Pharmacol Ther. 24:261-262. DOI.
  • Michaeloudes C; Sukkar MB; Khorasani NM; Bhavsar PK; Chung KF. (Feb 2011). TGF-β regulates Nox4, MnSOD and catalase expression, and IL-6 release in airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 300:L295-L304. DOI.
  • Gamble C; Talbott E; Youk A; Holguin F; Pitt B; Silveira L; Bleecker E; Busse W; et alCalhoun W; Castro M; Chung KF; Erzurum S; Israel E; Wenzel S. (Dec 2010). Racial differences in biologic predictors of severe asthma: Data from the Severe Asthma Research Program. J ALLERGY CLIN IMMUN. 126:1149-U133. DOI.
  • Bousquet J; Mantzouranis E; Cruz AA; Aït-Khaled N; Baena-Cagnani CE; Bleecker ER; Brightling CE; Burney P; et alBush A; Busse WW; Casale TB; Chan-Yeung M; Chen R; Chowdhury B; Chung KF; Dahl R; Drazen JM; Fabbri LM; Holgate ST; Kauffmann F; Haahtela T; Khaltaev N; Kiley JP; Masjedi MR; Mohammad Y; O'Byrne P; Partridge MR; Rabe KF; Togias A; van Weel C; Wenzel S; Zhong N; Zuberbier T. (Nov 2010). Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma. J Allergy Clin Immunol. 126:926-938. DOI.
  • Binia A; Khorasani N; Bhavsar PK; Adcock I; Brightling CE; Chung KF; Cookson WO; Moffatt MF. (Jan 2011). Chromosome 17q21 SNP and severe asthma. J Hum Genet. 56:97-98. DOI.
  • Adcock IM; Marwick J; Casolari P; Contoli M; Chung KF; Kirkham P; Papi A; Caramori G. (2010). Mechanisms of corticosteroid resistance in severe asthma and chronic obstructive pulmonary disease (COPD). Curr Pharm Des. 16:3554-3573.
  • Brasier AR; Victor S; Ju H; Busse WW; Curran-Everett D; Bleecker E; Castro M; Chung KF; et alGaston B; Israel E; Wenzel SE; Erzurum SC; Jarjour NN; Calhoun WJ. (Aug 2010). Predicting Intermediate Phenotypes in Asthma Using Bronchoalveolar Lavage-Derived Cytokines. CTS-CLIN TRANSL SCI. 3:147-157. DOI.
  • Chung KF; Marwick JA. (Aug 2010). Molecular mechanisms of oxidative stress in airways and lungs with reference to asthma and chronic obstructive pulmonary disease. Ann N Y Acad Sci. 1203:85-91. DOI.
  • Marwick JA; Stevenson CS; Chung KF; Adcock IM; Kirkham PA. (2010). Cigarette Smoke Exposure Alters mSin3a and Mi-2alpha/beta Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function. J Inflamm (Lond). 7:33. DOI.
  • Auffray C; Adcock IM; Chung KF; Djukanovic R; Pison C; Sterk PJ. (Jun 2010). An Integrative Systems Biology Approach to Understanding Pulmonary Diseases. CHEST. 137:1410-1416. DOI.
  • Larner-Svensson HM; Williams AE; Tsitsiou E; Perry MM; Jiang X; Chung KF; Lindsay MA. (2010). Pharmacological studies of the mechanism and function of interleukin-1beta-induced miRNA-146a expression in primary human airway smooth muscle. Respir Res. 11:68. DOI.
  • Bhavsar PK; Levy BD; Hew MJ; Pfeffer MA; Kazani S; Israel E; Chung KF. (2010). Corticosteroid suppression of lipoxin A4 and leukotriene B4 from alveolar macrophages in severe asthma. Respir Res. 11:71. DOI.
  • Dahl R; Chung KF; Buhl R; Magnussen H; Nonikov V; Jack D; Bleasdale P; Owen R; et alHiggins M; Kramer B; INVOLVE INdacaterol Value COPD Lo. (Jun 2010). Efficacy of a new once-daily long-acting inhaled beta(2)-agonist indacaterol versus twice-daily formoterol in COPD. THORAX. 65:473-479. DOI.
  • Hew M; Chung KF. (May 2010). Corticosteroid insensitivity in severe asthma: significance, mechanisms and aetiology. INTERN MED J. 40:323-334. DOI.
  • Chung KF. (Oct 2007). Should treatments for asthma be aimed at the airway smooth muscle?. Expert Rev Respir Med. 1:209-217. DOI.
  • Wang CH; Lin HC; Lin SM; Huang CD; Liu CV; Huang KH; Hsieh LL; Chung KF; et alKuo HP. (May 2010). MMP-1(-1607G) polymorphism as a risk factor for fibrosis after pulmonary tuberculosis in Taiwan. INT J TUBERC LUNG D. 14:627-634.
  • Marwick JA; Caramori G; Casolari P; Mazzoni F; Kirkham PA; Adcock IM; Chung KF; Papi A. (May 2010). A role for phosphoinositol 3-kinase delta in the impairment of glucocorticoid responsiveness in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol. 125:1146-1153. DOI.
  • Williams AE; Larner-Svensson H; Perry MM; Campbell GA; Herrick SE; Adcock IM; Erjefalt JS; Chung KF; et alLindsay MA. (12 Jun 2009). MicroRNA Expression Profiling in Mild Asthmatic Human Airways and Effect of Corticosteroid Therapy. PLOS ONE. 4. DOI Open Access copy.
  • Marwick JA; Chung KF; Adcock IM. (Feb 2010). Phosphatidylinositol 3-kinase isoforms as targets in respiratory disease. Ther Adv Respir Dis. 4:19-34. DOI.
  • Varani K; Caramori G; Vincenzi F; Tosi A; Barczyk A; Contoli M; Casolari P; Triggiani M; et alHansel T; Leung E; Maclennan S; Barnes PJ; Chung KF; Adcock I; Papi A; Borea PA. (Apr 2010). Oxidative/nitrosative stress selectively altered A(2B) adenosine receptors in chronic obstructive pulmonary disease. FASEB J. 24:1192-1204. DOI.
  • Di Stefano A; Caramori G; Gnemmi I; Contoli M; Bristot L; Capelli A; Ricciardolo FLM; Magno F; et alD'Anna SE; Zanini A; Carbone M; Sabatini F; Usai C; Brun P; Chung KF; Barnes PJ; Papi A; Adcock IM; Balbi B. (Nov 2009). Association of increased CCL5 and CXCL7 chemokine expression with neutrophil activation in severe stable COPD. THORAX. 64:968-975. DOI.
  • Macedo P; Saleh H; Torrego A; Arbery J; MacKay I; Durham SR; Chung KF. (Nov 2009). Postnasal drip and chronic cough: An open interventional study. RESP MED. 103:1700-1705. DOI.
  • Bhavsar P; Khorasani N; Hew M; Johnson M; Chung KF. (Apr 2010). Effect of p38 MAPK inhibition on corticosteroid suppression of cytokine release in severe asthma. Eur Respir J. 35:750-756. DOI.
  • Caramori G; Casolari P; Di Gregorio C; Saetta M; Baraldo S; Boschetto P; Ito K; Fabbri LM; et alBarnes PJ; Adcock IM; Cavallesco G; Chung KF; Papi A. (Sep 2009). MUC5AC expression is increased in bronchial submucosal glands of stable COPD patients. HISTOPATHOLOGY. 55:321-331. DOI.
  • Chung KF; Caramori G; Adcock IM. (Sep 2009). Inhaled corticosteroids as combination therapy with beta-adrenergic agonists in airways disease: present and future. EUR J CLIN PHARMACOL. 65:853-871. DOI.
  • Heffner JE; Holgate ST; Chung KF; Niederman MS; Daley CL; Jett JR; Stradling JR; Wells AU; et alLight RW; Tapson VF; Hansell DM; Provonost PJ; Lee YCG. (Jul 2009). Road ahead to respiratory health: Experts chart future research directions. RESPIROLOGY. 14:625-636. DOI.
  • Groneberg-Kloft B; Dinh QT; Scutaru C; Welte T; Fischer A; Chung KF; Quarcoo D. (2009). Cough as a symptom and a disease entity: scientometric analysis and density-equalizing calculations. J Investig Allergol Clin Immunol. 19:266-275.
  • Di Stefano A; Caramori G; Gnemmi I; Contoli M; Vicari C; Capelli A; Magno F; D'Anna SE; et alZanini A; Brun P; Casolari P; Chung KF; Barnes PJ; Papi A; Adcock I; Balbi B. (Aug 2009). T helper type 17-related cytokine expression is increased in the bronchial mucosa of stable chronic obstructive pulmonary disease patients. CLIN EXP IMMUNOL. 157:316-324. DOI.
  • Macedo P; Hew M; Torrego A; Jouneau S; Oates T; Durham A; Chung KF. (Nov 2009). Inflammatory biomarkers in airways of patients with severe asthma compared with non-severe asthma. Clin Exp Allergy. 39:1668-1676. DOI.
  • Menzies-Gow A; Chung KF. (Sep 2008). Omalizumab for the treatment of severe allergic asthma. EXPERT REV CLIN IMMU. 4:543-548. DOI.
  • Mahn K; Hirst SJ; Ying S; Holt MR; Lavender P; Ojo OO; Siew L; Simcock DE; et alMcVicker CG; Kanabar V; Snetkov VA; O'Connor BJ; Karner C; Cousins DJ; Macedo P; Chung KF; Corrigan CJ; Ward JPT; Lee TH. (30 Jun 2009). Diminished sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) expression contributes to airway remodelling in bronchial asthma. P NATL ACAD SCI USA. 106:10775-10780. DOI.
  • Xie SP; Macedo P; Hew M; Nassenstein C; Lee KY; Chung KF. (22 May 2009). Expression of transforming growth factor-beta (TGF-beta) in chronic idiopathic cough. RESP RES. 10. DOI.
  • Williams AS; Issa R; Durham A; Leung SY; Kapoun A; Medicherla S; Higgins LS; Adcock IM; et alChung KF. (1 May 2009). Role of p38 mitogen-activated protein kinase in ozone-induced airway hyperresponsiveness and inflammation (vol 600, pg 117, 2008). EUR J PHARMACOL. 609:155-156. DOI.
  • Blanc FX; Macedo P; Hew M; Chung KF. (May 2009). Capsaicin cough sensitivity in smokers with and without airflow obstruction. RESP MED. 103:786-790. DOI.
  • Chung KF; Bolser D; Davenport P; Fontana G; Morice A; Widdicombe J. (Apr 2009). Semantics and types of cough. PULM PHARMACOL THER. 22:139-142. DOI.
  • Chung KF; Widdicombe J. (Apr 2009). The 2008 Fifth International Cough Symposium: Mechanisms and treatment. PULM PHARMACOL THER. 22:57-58. DOI.
  • Caramori G; Oates T; Nicholson AG; Casolari P; Ito K; Barnes PJ; Papi A; Adcock IM; et alChung KF. (Mar 2009). Activation of NF-kappa B transcription factor in asthma death. HISTOPATHOLOGY. 54:507-509. DOI.
  • Groneberg-Kloft B; Scutaru C; Dinh QT; Welte T; Chung KF; Fischer A; Quarcoo D. (2009). Inter-disease Comparison of Research Quantity and Quality: Bronchial Asthma and Chronic Obstructive Pulmonary Disease. J ASTHMA. 46:147-152. DOI.
  • Oltmanns U; Walters M; Sukkar M; Xie S; Issa R; Mitchell J; Johnson M; Chung KF. (2008). Fluticasone, but not salmeterol, reduces cigarette smoke-induced production of interleukin-8 in human airway smooth muscle. PULM PHARMACOL THER. 21:292-297. DOI.
  • Leung SY; Williams AS; Nath P; Dinh QT; Oates T; Blanc FX; Eynott PR; Chung KF. (2008). Dose-dependent inhibition of allergic inflammation and bronchial hyperresponsiveness by budesonide in ovalbumin-sensitised Brown-Norway rats. PULM PHARMACOL THER. 21:98-104. DOI.
  • Williams AS; Eynott PR; Leung SY; Nath P; Jupp R; De Sanctis GT; Resnick R; Adcock IM; et alChung KF. (Feb 2009). Role of cathepsin S in ozone-induced airway hyperresponsiveness and inflammation. Pulm Pharmacol Ther. 22:27-32. DOI.
  • Takemura M; Quarcoo D; Niimi A; Dinh QT; Geppetti P; Fischer A; Chung KF; Groneberg DA. (Dec 2008). Is TRPV1 a useful target in respiratory diseases?. Pulm Pharmacol Ther. 21:833-839. DOI.
  • Chung KF; Widdicombe JG. (2009). Pharmacology and therapeutics of cough. Preface. Handb Exp Pharmacol. v-vi.
  • Chung KF; Widdicombe JG. (2009). Cough: setting the scene. Handb Exp Pharmacol. 1-21. DOI.
  • Chung KF. (2009). Clinical cough VI: the need for new therapies for cough: disease-specific and symptom-related antitussives. Handb Exp Pharmacol. 343-368. DOI.
  • Niven R; Chung KF; Panahloo Z; Blogg M; Ayre G. (Oct 2008). Effectiveness of omalizumab in patients with inadequately controlled severe persistent allergic asthma: An open-label study. RESP MED. 102:1371-1378. DOI.
  • Lara A; Khatri SB; Wang Z; Comhair SAA; Xu W; Dweik RA; Bodine M; Levison BS; et alHammel J; Bleecker E; Busse W; Calhoun WJ; Castro M; Chung KF; Curran-Everett D; Gaston B; Israel E; Jarjour N; Moore W; Peters SP; Teague WG; Wenzel S; Hazen SL; Erzurum SC; Natl Heart Lung & Blood Inst Sever. (1 Oct 2008). Alterations of the arginine metabolome in asthma. AM J RESP CRIT CARE. 178:673-681. DOI.
  • Liu WT; Wang CH; Lin HC; Lin SM; Lee KY; Lo YL; Hung SH; Chang YM; et alChung KF; Kuo HP. (Sep 2008). Efficacy of a cell phone-based exercise programme for COPD. EUR RESPIR J. 32:651-659. DOI.
  • Williams AS; Nath P; Leung SY; Khorasan N; McKenzie ANJ; Adcock IM; Chung KF. (Sep 2008). Modulation of ozone-induced airway hyperresponsiveness and inflammation by interleukin-13. EUR RESPIR J. 32:571-578. DOI.
  • Williams AS; Issa R; Durham A; Leung SY; Kapoun A; Medicherla S; Higgins LS; Adcock IM; et alChung KF. (14 Dec 2008). Role of p38 mitogen-activated protein kinase in ozone-induced airway hyperresponsiveness and inflammation. Eur J Pharmacol. 600:117-122. DOI.
  • Adcock IM; Caramori G; Chung KF. (20 Sep 2008). New targets for drug development in asthma. LANCET. 372:1073-1087.
  • Wang CH; Huang CD; Lin HC; Lee KY; Lin SM; Liu CY; Huang KH; Ko YS; et alChung KF; Kuo HP. (15 Sep 2008). Increased circulating fibrocytes in asthma with chronic airflow obstruction. AM J RESP CRIT CARE. 178:583-591. DOI.
  • Planaguma A; Kazani S; Marigowda G; Haworth O; Mariani TJ; Israel E; Bleecker ER; Curran-Everett D; et alErzurum SC; Calhoun WJ; Castro M; Chung KF; Gaston B; Jarjour NN; Busse WW; Wenzel SE; Levy BD; NHLBI Severe Asthma Res Program. (15 Sep 2008). Airway lipoxin A(4) generation and lipoxin A(4) receptor expression are decreased in severe asthma. AM J RESP CRIT CARE. 178:574-582. DOI.
  • Kaur M; Holden NS; Wilson SM; Sukkar MB; Chung KF; Barnes PJ; Newton R; Giembycz MA. (Sep 2008). Effect of beta(2)-adrenoceptor agonists and other cAMP-elevating agents on inflammatory gene expression in human ASM cells: a role for protein kinase A. AM J PHYSIOL-LUNG C. 295:L505-L514. DOI.
  • Bhavsar P; Hew M; Khorasani N; Torrego A; Barnes PJ; Adcock I; Chung KF. (Sep 2008). Relative corticosteroid insensitivity of alveolar macrophages in severe asthma compared with non-severe asthma. THORAX. 63:784-790. DOI.
  • Chung KF; Adcock IM. (Jun 2008). Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction. Eur Respir J. 31:1334-1356. DOI.
  • Issa R; Sorrentino R; Sukkar MB; Sriskandan S; Chung KF; Mitchell JA. (1 Apr 2008). Differential regulation of CCL-II/eotaxin-I and CXCL-8/IL-8 by Gram-positive and Gram-negative bacteria in human airway smooth muscle cells. RESP RES. 9. DOI.
  • Pavord ID; Chung KF. (19 Apr 2008). Chronic cough 2 - Management of chronic cough. LANCET. 371:1375-1384.
  • Chung KF; Pavord ID. (19 Apr 2008). Chronic cough 1 - Prevalence, pathogenesis, and causes of chronic cough. LANCET. 371:1364-1374.
  • Chung KF; Pavord ID. (19 Apr 2008). Prevalence, pathogenesis, and causes of chronic cough. Lancet. 371:1364-1374. DOI.
  • Adcock IM; Ford PA; Bhavsar P; Ahmad T; Chung KF. (Apr 2008). Steroid resistance in asthma: mechanisms and treatment options. Curr Allergy Asthma Rep. 8:171-178.
  • Leung SY; Niimi A; Williams AS; Nath P; Blanc FX; Dinh QT; Chung KF. (2007). Inhibition of citric acid- and capsaicin-induced cough by novel TRPV-1 antagonist, V112220, in guinea-pig. Cough. 3:10. DOI.
  • Sorkness RL; Bleecker ER; Busse WW; Calhoun WJ; Castro M; Chung KF; Curran-Everett D; Erzurum SC; et alGaston BM; Israel E; Jarjour NN; Moore WC; Peters SP; Teague WG; Wenzel SE; Natl Heart Lung Blood Inst Severe. (Feb 2008). Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation. J APPL PHYSIOL. 104:394-403. DOI.
  • Bhavsar PK; Sukkar MB; Khorasani N; Lee KY; Chung KF. (Jun 2008). Glucocorticoid suppression of CX3CL1 (fractalkine) by reduced gene promoter recruitment of NF-kappaB. FASEB J. 22:1807-1816. DOI.
  • Pavord ID; Cox G; Thomson NC; Rubin AS; Corris PA; Niven RM; Chung KF; Laviolette M; et alRISA Trial Study Grp. (15 Dec 2007). Safety and efficacy of bronchial thermoplasty in symptomatic, severe asthma. AM J RESP CRIT CARE. 176:1185-1191. DOI.
  • Ballantyne SJ; Barlow JL; Jolin HE; Nath P; Williams AS; Chung KF; Sturton G; Wong SH; et alMcKenzie ANJ. (Dec 2007). Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma. J ALLERGY CLIN IMMUN. 120:1324-1331. DOI.
  • McCreanor J; Cullinan P; Nieuwenhuijsen MJ; Stewart-Evans J; Malliarou E; Jarup L; Harrington R; Svartengren M; et alHan I; Ohman-Strickland P; Chung KF; Zhang JF. (6 Dec 2007). Respiratory effects of exposure to diesel traffic in persons with asthma. NEW ENGL J MED. 357:2348-2358.
  • Chung KF. (2006). Salmeterol/fluticasone combination in the treatment of COPD. Int J Chron Obstruct Pulmon Dis. 1:235-242.
  • Williams AS; Leung SY; Nath P; Khorasani NM; Bhavsar P; Issa R; Mitchell JA; Adcock IM; et alChung KF. (Oct 2007). Role of TLR2, TLR4, and MyD88 in murine ozone-induced airway hyperresponsiveness and neutrophilia. J APPL PHYSIOL. 103:1189-1195. DOI.
  • Chung KF. (2007). Chronic cough: future directions in chronic cough: mechanisms and antitussives. Chron Respir Dis. 4:159-165. DOI.
  • Nath P; Leung SY; Williams AS; Noble A; Xie S; McKenzie ANJ; Chung KF. (Oct 2007). Complete inhibition of allergic airway inflammation and remodelling in quadruple IL-4/5/9/13(-/-) mice. CLIN EXP ALLERGY. 37:1427-1435. DOI.
  • Lu D; Xie S; Sukkar MB; Lu X; Scully MF; Chung KF. (Oct 2007). Inhibition of airway smooth muscle adhesion and migration by the disintegrin domain of ADAM-15. Am J Respir Cell Mol Biol. 37:494-500. DOI.
  • Chung KF. (2008). Currently available cough suppressants for chronic cough. Lung. 186 Suppl 1:S82-S87. DOI.
  • Gupta D; Keogh B; Chung KF; Ayres JG; Harrison DA; Goldfrad C; Brady AR; Rowan K. (2005). Characteristics and outcome for admissions to adult, general critical care units with acute severe asthma: a secondary analysis of the ICNARC Case Mix Programme Database. CRIT CARE. 9.
  • Bousquet J; Rabe K; Humbert M; Chung KF; Berger W; Fox H; Ayre G; Chen H; et alThomas K; Blogg M; Holgate S. (Jul 2007). Predicting and evaluating response to omalizumab in patients with severe allergic asthma. RESP MED. 101:1483-1492. DOI.
  • Chung KF. (Mar 1996). Theophylline in chronic asthma - Evidence for disease-modifying properties. CLIN EXP ALLERGY. 26:22-27.
  • Morice AH; Fontana GA; Belvisi MG; Birring SS; Chung KF; Dicpinigaitis PV; Kastelik JA; McGarvey LP; et alSmith JA; Tatar M; Widdicombe J; European Respiratory Society (ERS). (Jun 2007). ERS guidelines on the assessment of cough. Eur Respir J. 29:1256-1276. DOI.
  • Widdicombe J; Chung KF. (2007). Cough. PULM PHARMACOL THER. 20:305-306. DOI.
  • Issa R; Xie S; Khorasani N; Sukkar M; Adcock IM; Lee KY; Chung KF. (1 Jun 2007). Corticosteroid inhibition of growth-related oncogene protein-alpha via mitogen-activated kinase phosphatase-1 in airway smooth muscle cells. J Immunol. 178:7366-7375.
  • Xie S; Sukkar MB; Issa R; Khorasani NM; Chung KF. (Jul 2007). Mechanisms of induction of airway smooth muscle hyperplasia by transforming growth factor-beta. Am J Physiol Lung Cell Mol Physiol. 293:L245-L253. DOI.
  • Williams AS; Issa R; Leung SY; Nath P; Ferguson GD; Bennett BL; Adcock IM; Chung KF. (Jul 2007). Attenuation of ozone-induced airway inflammation and hyper-responsiveness by c-Jun NH2 terminal kinase inhibitor SP600125. J Pharmacol Exp Ther. 322:351-359. DOI.
  • Wenzel SE; Balzar S; Ampleford E; Hawkins GA; Busse WW; Calhoun WJ; Castros M; Chung KF; et alErzurum S; Gaston B; Israel E; Teague WG; Curran-Everett D; Meyers DA; Bleecker ER. (15 Mar 2007). IL4R alpha mutations are associated with asthma exacerbations and mast cell/IgE expression. AM J RESP CRIT CARE. 175:570-576. DOI.
  • Torrego A; Hew M; Oates T; Sukkar M; Fan Chung K. (Apr 2007). Expression and activation of TGF-beta isoforms in acute allergen-induced remodelling in asthma. Thorax. 62:307-313. DOI.
  • Chung KF. (Dec 2005). Inflammatory mediators in chronic obstructive pulmonary disease. Curr Drug Targets Inflamm Allergy. 4:619-625.
  • Moore WC; Bleecker ER; Curran-Everett D; Erzurum SC; Ameredes BT; Bacharier L; Calhoun WJ; Castro M; et alChung KF; Clark MP; Dweik RA; Fitzpatrick AM; Gaston B; Hew M; Hussain I; Jarjour NN; Israel E; Levy BD; Murphy JR; Peters SP; Teague WG; Meyers DA; Busse WW; Wenzel SE; National Heart, Lung, Blood Institute's Severe Asthma Research Program. (Feb 2007). Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. J Allergy Clin Immunol. 119:405-413. DOI.
  • McVicker CG; Leung SY; Kanabar V; Moir LM; Mahn K; Chung KF; Hirst SJ. (Jun 2007). Repeated allergen inhalation induces cytoskeletal remodeling in smooth muscle from rat bronchioles. Am J Respir Cell Mol Biol. 36:721-727. DOI.
  • Chung KF. (2007). Effective antitussives for the cough patient: an unmet need. Pulm Pharmacol Ther. 20:438-445. DOI.
  • Chung KF. (15 Nov 2006). Intrinsic differences of the airway epithelium in childhood allergic asthma. AM J RESP CRIT CARE. 174:1066-1067. DOI.
  • Leung SY; Niimi A; Noble A; Oates T; Williams AS; Medicherla S; Protter AA; Chung KF. (Nov 2006). Effect of transforming growth factor-beta receptor I kinase inhibitor 2,4-disubstituted pteridine (SD-208) in chronic allergic airway inflammation and remodeling. J Pharmacol Exp Ther. 319:586-594. DOI.
  • Lu D; Chung KF; Xia M; Lu XJ; Scully M; Kakkar V. (Nov 2006). Integrin binding characteristics of the disintegrin-like domain of ADAM-15. THROMB HAEMOSTASIS. 96:642-651. DOI.
  • Lee KY; Ho SC; Lin HC; Lin SM; Liu CY; Huang CD; Wang CH; Chung KF; et alKuo HP. (Oct 2006). Neutrophil-derived elastase induces TGF-beta 1 secretion in human airway smooth muscle via NF-kappa B pathway. AM J RESP CELL MOL. 35:407-414. DOI.
  • Sukkar MB; Xie S; Khorasani NM; Kon OM; Stanbridge R; Issa R; Chung KF. (Sep 2006). Toll-like receptor 2, 3, and 4 expression and function in human airway smooth muscle. J Allergy Clin Immunol. 118:641-648. DOI.
  • Nath P; Leung SY; Williams A; Noble A; Chakravarty SD; Luedtke GR; Medicherla S; Higgins LS; et alProtter A; Chung KF. (21 Aug 2006). Importance of p38 mitogen-activated protein kinase pathway in allergic airway remodelling and bronchial hyperresponsiveness. Eur J Pharmacol. 544:160-167. DOI.
  • Torrego A; Haque RA; Nguyen LT; Hew M; Carr DH; Wilson R; Chung KF. (Aug 2006). Capsaicin cough sensitivity in bronchiectasis. Thorax. 61:706-709. DOI.
  • Dinh QT; Cryer A; Trevisani M; Dinh S; Wu S; Cifuentes LB; Feleszko WK; Williams A; et alGeppetti P; Chung KF; Heppt W; Klapp BF; Fischer A. (Aug 2006). Gene and protein expression of protease-activated receptor 2 in structural and inflammatory cells in the nasal mucosa in seasonal allergic rhinitis. CLIN EXP ALLERGY. 36:1039-1048.
  • Catley MC; Sukkar MB; Chung KF; Jaffee B; Liao SM; Coyle AJ; Haddad EL-B; Barnes PJ; et alNewton R. (Aug 2006). Validation of the anti-inflammatory properties of small-molecule IkappaB Kinase (IKK)-2 inhibitors by comparison with adenoviral-mediated delivery of dominant-negative IKK1 and IKK2 in human airways smooth muscle. Mol Pharmacol. 70:697-705. DOI.
  • Chung KF. (28 Jul 2006). Measurement of cough. Respir Physiol Neurobiol. 152:329-339. DOI.
  • Hew M; Bhavsar P; Torrego A; Meah S; Khorasani N; Barnes PJ; Adcock I; Chung KF. (15 Jul 2006). Relative corticosteroid insensitivity of peripheral blood mononuclear cells in severe asthma. Am J Respir Crit Care Med. 174:134-141. DOI.
  • Issa R; Xie S; Lee KY; Stanbridge RD; Bhavsar P; Sukkar MB; Chung KF. (Jul 2006). GRO-alpha regulation in airway smooth muscle by IL-1beta and TNF-alpha: role of NF-kappaB and MAP kinases. Am J Physiol Lung Cell Mol Physiol. 291:L66-L74. DOI.
  • Chung KF. (Jun 2006). Cytokines as targets in chronic obstructive pulmonary disease. Curr Drug Targets. 7:675-681.
  • Mann BS; Chung KF. (6 Apr 2006). Blood neutrophil activation markers in severe asthma: lack of inhibition by prednisolone therapy. RESP RES. 7. DOI.
  • Bayram H; Ito K; Issa R; Ito M; Sukkar M; Chung KF. (Apr 2006). Regulation of human lung epithelial cell numbers by diesel exhaust particles. Eur Respir J. 27:705-713. DOI.
  • Chung KF; McGarvey L; Widdicombe J. (25 Mar 2006). American College of Chest Physicians' cough guidelines. LANCET. 367:981-982.
  • Adcock IM; Chung KF; Caramori G; Ito K. (8 Mar 2006). Kinase inhibitors and airway inflammation. Eur J Pharmacol. 533:118-132. DOI.
  • Chung KF. (8 Mar 2006). Phosphodiesterase inhibitors in airways disease. EUR J PHARMACOL. 533:110-117. DOI.
  • Ito K; Chung KF; Adcock IM. (Mar 2006). Update on glucocorticoid action and resistance. J Allergy Clin Immunol. 117:522-543. DOI.
  • Varani K; Caramori G; Vincenzi F; Adcock I; Casolari P; Leung E; MacLennan S; Gessi S; et alMorello S; Barnes PJ; Ito K; Chung KF; Cavallesco G; Azzena G; Papi A; Borea PA. (15 Feb 2006). Alteration of adenosine receptors in patients with chronic obstructive pulmonary disease. AM J RESP CRIT CARE. 173:398-406. DOI.
  • Chung KF. (2006). Beclometasone dipropionate/formoterol in an HFA-propelled pressurised metered-dose inhaler. DRUGS. 66:1484-1485.
  • Chung KF. (2006). Beclometasone Dipropionate/Formoterol in an HFA-Propelled Pressurised Metered-Dose Inhaler: A Viewpoint by K.F. Chung. Drugs. 66:1484-1485. Publisher weblink.
  • Chung KF; Hew M; Score J; Jones AV; Reiter A; Cross NC; Bain BJ. (Jan 2006). Cough and hypereosinophilia due to FIP1L1-PDGFRA fusion gene with tyrosine kinase activity. Eur Respir J. 27:230-232. DOI.
  • Ricciardolo FLM; Caramori G; Ito K; Capelli A; Brun P; Abatangelo G; Papi A; Chung KF; et alAdcock I; Barnes PJ; Donner CF; Rossi A; Di Stefano A. (Nov 2005). Nitrosative stress in the bronchial mucosa of severe chronic obstructive pulmonary disease. J ALLERGY CLIN IMMUN. 116:1028-1035. DOI.
  • Chung KF; Adcock IM. (Nov 2005). Signalling and transcriptional regulation in inflammatory and immune cells: importance in lung biology and disease. EUR RESPIR J. 26:762-763. DOI.
  • Torrego A; Cimbollek S; Hew M; Chung KF. (19 Oct 2005). No effect of omeprazole on pH of exhaled breath condensate in cough associated with gastro-oesophageal reflux. Cough. 1:10. DOI.
  • Chung KF. (27 Sep 2005). Evaluation of selective prostaglandin E2 (PGE2) receptor agonists as therapeutic agents for the treatment of asthma. Sci STKE. 2005:pe47. DOI.
  • Niimi A; Torrego A; Nicholson AG; Cosio BG; Oates TB; Chung KF. (Sep 2005). Nature of airway inflammation and remodeling in chronic cough. J Allergy Clin Immunol. 116:565-570. DOI.
  • Wang CH; Liu CY; Wan YL; Chou CL; Huang KH; Lin HC; Lin SM; Lin TY; et alChung KF; Kuo HP. (11 May 2005). Persistence of lung inflammation and lung cytokines with high-resolution CT abnormalities during recovery from SARS. RESP RES. 6. DOI.
  • Leung SY; Eynott P; Nath P; Chung KF. (May 2005). Effects of ciclesonide and fluticasone propionate on allergen-induced airway inflammation and remodeling features. J Allergy Clin Immunol. 115:989-996. DOI.
  • Oltmanns U; Sukkar MB; Xie S; John M; Chung KF. (Apr 2005). Induction of human airway smooth muscle apoptosis by neutrophils and neutrophil elastase. Am J Respir Cell Mol Biol. 32:334-341. DOI.
  • Chung KF. (Mar 2005). H+/K+-ATPase (proton pump) inhibitors dampen increased cough reflex: more than gastric acid suppression. CLIN EXP ALLERGY. 35:245-246. DOI.
  • Chung KF; Gronenberg DA. (Feb 2005). Effects of cigarette smoke on pulmonary homeostasis. AM J RESP CELL MOL. 32:167-167. DOI.
  • Nguyen LT; Lim S; Oates T; Chung KF. (Feb 2005). Increase in airway neutrophils after oral but not inhaled corticosteroid therapy in mild asthma. Respir Med. 99:200-207.
  • Chung KF. (Feb 2005). Pathophysiology and therapy of chronic cough. Minerva Med. 96:29-40.
  • Nath P; Eynott P; Leung SY; Adcock IM; Bennett BL; Chung KF. (4 Jan 2005). Potential role of c-Jun NH2-terminal kinase in allergic airway inflammation and remodelling: effects of SP600125. Eur J Pharmacol. 506:273-283. DOI.
  • Oltmanns U; Chung KF; Walters M; John M; Mitchell JA. (2005). Cigarette smoke induces IL-8, but inhibits eotaxin and RANTES release from airway smooth muscle. Respir Res. 6:74. DOI.
  • Chung KF. (Jan 2005). Drugs to suppress cough. Expert Opin Investig Drugs. 14:19-27. DOI.
  • Xie S; Issa R; Sukkar MB; Oltmanns U; Bhavsar PK; Papi A; Caramori G; Adcock I; et alChung KF. (2005). Induction and regulation of matrix metalloproteinase-12 in human airway smooth muscle cells. Respir Res. 6:148. DOI.
  • Xie S; Sukkar MB; Issa R; Oltmanns U; Nicholson AG; Chung KF. (Jan 2005). Regulation of TGF-beta 1-induced connective tissue growth factor expression in airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 288:L68-L76. DOI.
  • Chung KF. (2005). The role of airway smooth muscle in the pathogenesis of airway wall remodeling in chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2:347-354. DOI.
  • Groneberg DA; Peiser C; Eynott PR; Welker P; Erbes R; Witt C; Chung KF; Fischer A. (Jan 2005). Transcriptional down-regulation of neurotrophin-3 in chronic obstructive pulmonary disease. Biol Chem. 386:53-59. DOI.
  • Groneberg DA; Niimi A; Dinh QT; Cosio B; Hew M; Fischer A; Chung KF. (15 Dec 2004). Increased expression of transient receptor potential vanilloid-1 in airway nerves of chronic cough. Am J Respir Crit Care Med. 170:1276-1280. DOI.
  • Sukkar MB; Issa R; Xie S; Oltmanns U; Newton R; Chung KF. (Dec 2004). Fractalkine/CX3CL1 production by human airway smooth muscle cells: induction by IFN-gamma and TNF-alpha and regulation by TGF-beta and corticosteroids. Am J Physiol Lung Cell Mol Physiol. 287:L1230-L1240. DOI.
  • Zhai W; Eynott PR; Oltmanns U; Leung SY; Chung KF. (Dec 2004). Mitogen-activated protein kinase signalling pathways in IL-1 beta-dependent rat airway smooth muscle proliferation. Br J Pharmacol. 143:1042-1049. DOI.
  • Groneberg DA; Chung KF. (2 Nov 2004). Models of chronic obstructive pulmonary disease. RESP RES. 5. DOI.
  • Caramori G; Di Gregorio C; Carlstedt I; Casolari P; Guzzinati I; Adcock IM; Barnes PJ; Ciaccia A; et alCavallesco G; Chung KF; Papi A. (Nov 2004). Mucin expression in peripheral airways of patients with chronic obstructive pulmonary disease. HISTOPATHOLOGY. 45:477-484.
  • Chung KF. (Oct 2004). Maximal airway plateau responses and eosinophils in cough variant asthma. Allergy. 59:1053-1054. DOI.
  • Chung KF; Caramori G; Groneberg DA. (30 Sep 2004). Airway obstruction in chronic obstructive pulmonary disease. NEW ENGL J MED. 351:1459-1460.
  • Djukanovic R; Wilson SJ; Kraft M; Jarjour NN; Steel M; Chung KF; Bao WB; Fowler-Taylor A; et alMatthews J; Busse WW; Holgate ST; Fahy JV. (15 Sep 2004). Effects of treatment with anti-immunoglobulin E antibody omalizumab on airway inflammation in allergic asthma. AM J RESP CRIT CARE. 170:583-593. DOI.
  • Jarai G; Sukkar M; Garrett S; Duroudier N; Westwick J; Adcock I; Chung KF. (30 Aug 2004). Effects of interleukin-1 beta, interleukin-13 and transforming growth factor-beta on gene expression in human airway smooth muscle using gene microarrays. EUR J PHARMACOL. 497:255-265. DOI.
  • Cosío BG; Mann B; Ito K; Jazrawi E; Barnes PJ; Chung KF; Adcock IM. (15 Jul 2004). Histone acetylase and deacetylase activity in alveolar macrophages and blood mononocytes in asthma. Am J Respir Crit Care Med. 170:141-147. DOI.
  • Risse PA; Naline E; Faisy C; Huchon G; Chung KF; Kleinmann P; Advenier C; Roche N. (9 Jul 2004). Protease-activated receptor 2 in regulation of bronchomotor tone: Effect of tobacco smoking. LIFE SCI. 75:991-1002. DOI.
  • Bucchioni E; Csoma Z; Allegra L; Chung KF; Barnes PJ; Kharitonov SA. (Jul 2004). Adenosine 5'-monophosphate increases levels of leukotrienes in breath condensate in asthma. Respir Med. 98:651-655.
  • Eynott PR; Xu L; Bennett BL; Noble A; Leung SY; Nath P; Groneberg DA; Adcock IM; et alChung KF. (Jul 2004). Effect of an inhibitor of Jun N-terminal protein kinase, SP600125, in single allergen challenge in sensitized rats. Immunology. 112:446-453. DOI.
  • Bumbacea D; Campbell D; Nguyen L; Carr D; Barnes PJ; Robinson D; Chung KF. (Jul 2004). Parameters associated with persistent airflow obstruction in chronic severe asthma. EUR RESPIR J. 24:122-128. DOI.
  • Niimi A; Nguyen LT; Usmani O; Mann B; Chung KF. (Jul 2004). Reduced pH and chloride levels in exhaled breath condensate of patients with chronic cough. Thorax. 59:608-612.
  • Di Stefano A; Caramori G; Capelli A; Gnemmi I; Ricciardolo FL; Oates T; Donner CF; Chung KF; et alBarnes PJ; Adcock IM. (Jul 2004). STAT4 activation in smokers and patients with chronic obstructive pulmonary disease. EUR RESPIR J. 24:78-85. DOI.
  • Atzori L; Caramori G; Lim S; Jazrawi E; Donnelly L; Adcock I; Barnes PJ; Chung KF. (Jun 2004). Effect of cigarette smoking on haem-oxygenase expression in alveolar macrophages. Respir Med. 98:530-535.
  • Koch A; Giembycz M; Stirling RG; Lim S; Adcock I; Wassermann K; Erdmann E; Chung KF. (Jun 2004). Effect of smoking on MAP kinase-induced modulation of IL-8 in human alveolar macrophages. EUR RESPIR J. 23:805-812. DOI.
  • Holgate ST; Bousquet J; Chung KF; Bisgaard H; Pauwels R; Fabbri L; Rabe K; Doherty M; et alSnell NJC; Cuss F; D'Amato M; Reginster JY; Grp for the Respect of Ethics and. (Jun 2004). Summary of recommendations for the design of clinical trials and the registration of drugs used in the treatment of asthma. RESP MED. 98:479-487. DOI.
  • Lim S; Caramori G; Tomita K; Jazrawi E; Oates T; Chung KF; Barnes PJ; Adcock IM. (May 2004). Differential expression of IL-10 receptor by epithelial cells and alveolar macrophages. Allergy. 59:505-514. DOI.
  • Bumbacea D; Scheerens J; Mann BS; Stirling RG; Chung KF. (May 2004). Failure of sputum eosinophilia after eotaxin inhalation in asthma. Thorax. 59:372-375.
  • Gupta D; Keogh B; Chung KF; Ayres JG; Harrison DA; Goldfrad C; Brady AR; Rowan K. (Apr 2004). Characteristics and outcome for admissions to adult, general critical care units with acute severe asthma: a secondary analysis of the ICNARC Case Mix Programme Database. Crit Care. 8:R112-R121. DOI.
  • Koch A; Giembycz M; Ito K; Lim S; Jazrawi E; Barnes PJ; Adcock I; Erdmann E; et alChung KF. (Mar 2004). Mitogen-activated protein kinase modulation of nuclear factor-kappaB-induced granulocyte macrophage-colony-stimulating factor release from human alveolar macrophages. Am J Respir Cell Mol Biol. 30:342-349. DOI.
  • Groneberg DA; Fischer A; Chung KF; Daniel H. (Mar 2004). Molecular mechanisms of pulmonary peptidomimetic drug and peptide transport. Am J Respir Cell Mol Biol. 30:251-260. DOI.
  • Chung KF. (Feb 2004). Anti-IgE monoclonal antibody, omalizumab: a new treatment for allergic asthma. Expert Opin Pharmacother. 5:439-446. DOI.
  • Leung SY; Eynott P; Noble A; Nath P; Chung KF. (Feb 2004). Resolution of allergic airways inflammation but persistence of airway smooth muscle proliferation after repeated allergen exposures. Clin Exp Allergy. 34:213-220.
  • Chung KF; Widdicombe J. (2004). Acute and chronic cough. Pulm Pharmacol Ther. 17:471-473. DOI.
  • Niimi A; Chung KF. (2004). Airway inflammation and remodelling changes in patients with chronic cough: do they tell us about the cause of cough?. Pulm Pharmacol Ther. 17:441-446. DOI.
  • Chung KF; Adcock IM. (2004). Combination therapy of long-acting beta2-adrenoceptor agonists and corticosteroids for asthma. Treat Respir Med. 3:279-289.
  • Chung KF; Widdicombe JG. (2004). Cough as a symptom. PULM PHARMACOL THER. 17:329-332. DOI.
  • Gabrijelcic J; Casas A; Rabinovich RA; Roca J; Barberà JA; Chung KF; Rodríguez-Roisin R. (Jan 2004). Formoterol protects against platelet-activating factor-induced effects in asthma. Eur Respir J. 23:71-75.
  • John M; Oltmanns U; Binder C; Meiners S; Gellert K; Chung KF; Witt C. (2004). Inhibition of chemokine production from human airway smooth muscle cells by fluticasone, budesonide and beclomethasone. Pulm Pharmacol Ther. 17:41-47. DOI.
  • Groneberg DA; Wagner U; Chung KF. (1 Jan 2004). Mucus and fatal asthma. Am J Med. 116:66-67.
  • Groneberg DA; Folkerts G; Peiser C; Chung KF; Fischer A. (2004). Neuropeptide Y (NPY). Pulm Pharmacol Ther. 17:173-180. DOI.
  • Eynott PR; Nath P; Leung SY; Adcock IM; Bennett BL; Chung KF. (Dec 2003). Allergen-induced inflammation and airway epithelial and smooth muscle cell proliferation: role of Jun N-terminal kinase. Br J Pharmacol. 140:1373-1380. DOI.
  • Chung KF. (Nov 2003). Individual cytokines contributing to asthma pathophysiology: valid targets for asthma therapy?. Curr Opin Investig Drugs. 4:1320-1326.
  • Groneberg DA; Zhang L; Welte T; Zabel P; Chung KF. (Nov 2003). Severe acute respiratory syndrome: global initiatives for disease diagnosis. QJM. 96:845-852.
  • Chung KF; Blanc FX. (Sep 2003). [Severe asthma: can we do better?]. Rev Mal Respir. 20:495-500.
  • Robinson DS; Campbell DA; Durham SR; Pfeffer J; Barnes PJ; Chung KF; Asthma and Allergy Research Group of the National Heart and Lung Institute. (Sep 2003). Systematic assessment of difficult-to-treat asthma. Eur Respir J. 22:478-483.
  • Chung KF. (Aug 2003). Current and future prospects for drugs to suppress cough. IDrugs. 6:781-786.
  • Kips JC; Anderson GP; Fredberg JJ; Herz U; Inman MD; Jordana M; Kemeny DM; Lötvall J; et alPauwels RA; Plopper CG; Schmidt D; Sterk PJ; Van Oosterhout AJ; Vargaftig BB; Chung KF. (Aug 2003). Murine models of asthma. Eur Respir J. 22:374-382.
  • Gabrijelcic J; Acuña A; Profita M; Paternò A; Chung KF; Vignola AM; Rodríguez-Roisin R. (Aug 2003). Neutrophil airway influx by platelet-activating factor in asthma: role of adhesion molecules and LTB4 expression. Eur Respir J. 22:290-297.
  • Eynott PR; Salmon M; Huang TJ; Oates T; Nicklin PL; Chung KF. (Jul 2003). Effects of cyclosporin A and a rapamycin derivative (SAR943) on chronic allergic inflammation in sensitized rats. Immunology. 109:461-467.
  • Oltmanns U; Issa R; Sukkar MB; John M; Chung KF. (Jul 2003). Role of c-jun N-terminal kinase in the induced release of GM-CSF, RANTES and IL-8 from human airway smooth muscle cells. Br J Pharmacol. 139:1228-1234. DOI.
  • Groneberg DA; Witt C; Wagner U; Chung KF; Fischer A. (Apr 2003). Fundamentals of pulmonary drug delivery. Respir Med. 97:382-387.
  • Caramori G; Romagnoli M; Casolari P; Bellettato C; Casoni G; Boschetto P; Chung KF; Barnes PJ; et alAdcock IM; Ciaccia A; Fabbri LM; Papi A. (Apr 2003). Nuclear localisation of p65 in sputum macrophages but not in sputum neutrophils during COPD exacerbations. THORAX. 58:348-351.
  • Groneberg DA; Peiser C; Dinh QT; Matthias J; Eynott PR; Heppt W; Carlstedt I; Witt C; et alFischer A; Chung KF. (Mar 2003). Distribution of respiratory mucin proteins in human nasal mucosa. Laryngoscope. 113:520-524. DOI.
  • Wang CH; Lin HC; Lin CH; Yu CT; Liu SL; Huang KH; Chung KF; Kuo HP. (Mar 2003). Effect of theophylline and specific phosphodiesterase IV inhibition on proliferation and apoptosis of progenitor cells in bronchial asthma. Br J Pharmacol. 138:1147-1155. DOI.
  • Roche N; Stirling RG; Lim S; Oliver BG; Chung KF. (Mar 2003). Regulation of protease-activated receptor-1 in mononuclear cells by neutrophil proteases. Respir Med. 97:228-233.
  • Roche N; Stirling RG; Lim S; Oliver BG; Oates T; Jazrawi E; Caramori G; Chung KF. (Feb 2003). Effect of acute and chronic inflammatory stimuli on expression of protease-activated receptors 1 and 2 in alveolar macrophages. J Allergy Clin Immunol. 111:367-373.
  • Moir LM; Leung SY; Eynott PR; McVicker CG; Ward JP; Chung KF; Hirst SJ. (Jan 2003). Repeated allergen inhalation induces phenotypic modulation of smooth muscle in bronchioles of sensitized rats. Am J Physiol Lung Cell Mol Physiol. 284:L148-L159. DOI.
  • Eynott PR; Paavolainen N; Groneberg DA; Noble A; Salmon M; Nath P; Leung SY; Chung KF. (Jan 2003). Role of nitric oxide in chronic allergen-induced airway cell proliferation and inflammation. J Pharmacol Exp Ther. 304:22-29. DOI.
  • Chung F; Barnes N; Allen M; Angus R; Corris P; Knox A; Miles J; Morice A; et alO'Reilly J; Richardson M. (Dec 2002). Assessing the burden of respiratory disease in the UK. Respir Med. 96:963-975.
  • Eynott PR; Groneberg DA; Caramori G; Adcock IM; Donnelly LE; Kharitonov S; Barnes PJ; Chung KF. (22 Nov 2002). Role of nitric oxide in allergic inflammation and bronchial hyperresponsiveness (vol 452, pg 123, 2002). EUR J PHARMACOL. 455:79-79.
  • Mattos W; Lim S; Russell R; Jatakanon A; Chung KF; Barnes PJ. (Nov 2002). Matrix metalloproteinase-9 expression in asthma: effect of asthma severity, allergen challenge, and inhaled corticosteroids. Chest. 122:1543-1552.
  • Eynott PR; Groneberg DA; Caramori G; Adcock IM; Donnelly LE; Kharitonov S; Barnes PJ; Chung KF. (27 Sep 2002). Role of nitric oxide in allergic inflammation and bronchial hyperresponsiveness. Eur J Pharmacol. 452:123-133.
  • Di Stefano A; Caramori G; Oates T; Capelli A; Lusuardi M; Gnemmi I; Ioli F; Chung KF; et alDonner CF; Barnes PJ; Adcock IM. (Sep 2002). Increased expression of nuclear factor-kappaB in bronchial biopsies from smokers and patients with COPD. Eur Respir J. 20:556-563.
  • Tomita K; Caramori G; Lim S; Ito K; Hanazawa T; Oates T; Chiselita I; Jazrawi E; et alChung KF; Barnes PJ; Adcock IM. (1 Sep 2002). Increased p21(CIP1/WAF1) and B cell lymphoma leukemia-x(L) expression and reduced apoptosis in alveolar macrophages from smokers. Am J Respir Crit Care Med. 166:724-731.
  • Chung KF. (Aug 2002). Anti-IgE therapy of asthma. Curr Opin Investig Drugs. 3:1157-1160.
  • Ito K; Caramori G; Lim S; Oates T; Chung KF; Barnes PJ; Adcock IM. (1 Aug 2002). Expression and activity of histone deacetylases in human asthmatic airways. Am J Respir Crit Care Med. 166:392-396.
  • Chung KF; van Rensen E; Stirling R; Barnes PJ. (Aug 2002). IL-5 in asthma. Thorax. 57:751.
  • Chung KF. (Jul 2002). Cough: potential pharmacological developments. Expert Opin Investig Drugs. 11:955-963. DOI.
  • Ito K; Lim S; Caramori G; Cosio B; Chung KF; Adcock IM; Barnes PJ. (25 Jun 2002). A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression. Proc Natl Acad Sci U S A. 99:8921-8926. DOI.
  • Acuña AA; Gabrijelcic J; Uribe EM; Rabinovich R; Roca J; Barberà JA; Chung KF; Rodriguez-Roisin R. (May 2002). Fluticasone propionate attenuates platelet-activating factor-induced gas exchange defects in mild asthma. Eur Respir J. 19:872-878.
  • Newton R; Eddleston J; Haddad EL-B; Hawisa S; Mak J; Lim S; Fox AJ; Donnelly LE; et alChung KF. (26 Apr 2002). Regulation of kinin receptors in airway epithelial cells by inflammatory cytokines and dexamethasone. Eur J Pharmacol. 441:193-202.
  • Groneberg DA; Eynott PR; Lim S; Oates T; Wu R; Carlstedt I; Roberts P; McCann B; et alNicholson AG; Harrison BD; Chung KF. (Apr 2002). Expression of respiratory mucins in fatal status asthmaticus and mild asthma. Histopathology. 40:367-373.
  • Irusen E; Matthews JG; Takahashi A; Barnes PJ; Chung KF; Adcock IM. (Apr 2002). p38 Mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: role in steroid-insensitive asthma. J Allergy Clin Immunol. 109:649-657.
  • Tomita K; Lim S; Hanazawa T; Usmani O; Stirling R; Chung KF; Barnes PJ; Adcock IM. (Mar 2002). Attenuated production of intracellular IL-10 and IL-12 in monocytes from patients with severe asthma. Clin Immunol. 102:258-266. DOI.
  • Huang TJ; Eynott P; Salmon M; Nicklin PL; Chung KF. (22 Feb 2002). Effect of topical immunomodulators on acute allergic inflammation and bronchial hyperresponsiveness in sensitised rats. Eur J Pharmacol. 437:187-194.
  • Groneberg DA; Eynott PR; Oates T; Lim S; Wu R; Carlstedt I; Nicholson AG; Chung KF. (Feb 2002). Expression of MUC5AC and MUC5B mucins in normal and cystic fibrosis lung. Respir Med. 96:81-86.
  • Mak JC; Hisada T; Salmon M; Barnes PJ; Chung KF. (Feb 2002). Glucocorticoids reverse IL-1beta-induced impairment of beta-adrenoceptor-mediated relaxation and up-regulation of G-protein-coupled receptor kinases. Br J Pharmacol. 135:987-996. DOI.
  • Chung KF. (2002). Assessment and measurement of cough: the value of new tools. Pulm Pharmacol Ther. 15:267-272. DOI.
  • Groneberg DA; Eynott PR; Döring F; Dinh QT; Oates T; Barnes PJ; Chung KF; Daniel H; et alFischer A. (Jan 2002). Distribution and function of the peptide transporter PEPT2 in normal and cystic fibrosis human lung. Thorax. 57:55-60.
  • Adcock IM; Chung KF. (Jan 2002). Overview: why are corticosteroids ineffective in COPD?. Curr Opin Investig Drugs. 3:58-60.
  • Chung KF; Chang AB. (2002). Therapy for cough: active agents. Pulm Pharmacol Ther. 15:335-338. DOI.
  • Lazzeri N; Belvisi MG; Patel HJ; Chung KF; Yacoub MH; Mitchell JA. (21 Dec 2001). RANTES release by human airway smooth muscle: effects of prostaglandin E(2) and fenoterol. Eur J Pharmacol. 433:231-235.
  • Chung KF. (Dec 2001). Cytokines in chronic obstructive pulmonary disease. Eur Respir J Suppl. 34:50s-59s.
  • van Rensen EL; Stirling RG; Scheerens J; Staples K; Sterk PJ; Barnes PJ; Chung KF. (Dec 2001). Evidence for systemic rather than pulmonary effects of interleukin-5 administration in asthma. Thorax. 56:935-940.
  • Kuo HP; Wang CH; Lin HC; Hwang KS; Liu SL; Chung KF. (Dec 2001). Interleukin-5 in growth and differentiation of blood eosinophil progenitors in asthma: effect of glucocorticoids. Br J Pharmacol. 134:1539-1547. DOI.
  • Chung KF; Ayres JG; Szczepura A; Atkinson M; Pavord ID; Holmes W; Findlay A; Meah S; et alGroves J; Podovinskaya Y. (Dec 2001). Triggers and type of asthma in patients with at risk severe asthma: Data from the PARA UK database. THORAX. 56:33-33.
  • Huang TJ; Adcock IM; Chung KF. (Nov 2001). A novel transcription factor inhibitor, SP100030, inhibits cytokine gene expression, but not airway eosinophilia or hyperresponsiveness in sensitized and allergen-exposed rat. Br J Pharmacol. 134:1029-1036. DOI.
  • Oliver B; Tomita K; Keller A; Caramori G; Adcock I; Chung KF; Barnes PJ; Lim S. (Nov 2001). Low-dose theophylline does not exert its anti-inflammatory effects in mild asthma through upregulation of interleukin-10 in alveolar macrophages. Allergy. 56:1087-1090.
  • Knight DA; Lim S; Scaffidi AK; Roche N; Chung KF; Stewart GA; Thompson PJ. (Nov 2001). Protease-activated receptors in human airways: upregulation of PAR-2 in respiratory epithelium from patients with asthma. J Allergy Clin Immunol. 108:797-803. DOI.
  • Stirling RG; van Rensen EL; Barnes PJ; Chung KF. (15 Oct 2001). Interleukin-5 induces CD34(+) eosinophil progenitor mobilization and eosinophil CCR3 expression in asthma. Am J Respir Crit Care Med. 164:1403-1409.
  • Caramori G; Lim S; Ito K; Tomita K; Oates T; Jazrawi E; Chung KF; Barnes PJ; et alAdcock IM. (Sep 2001). Expression of GATA family of transcription factors in T-cells, monocytes and bronchial biopsies. Eur Respir J. 18:466-473.
  • Stirling RG; Chung KF. (Sep 2001). Severe asthma: definition and mechanisms. Allergy. 56:825-840.
  • Lim S; Tomita K; Caramori G; Jatakanon A; Oliver B; Keller A; Adcock I; Chung KF; et alBarnes PJ. (15 Jul 2001). Low-dose theophylline reduces eosinophilic inflammation but not exhaled nitric oxide in mild asthma. Am J Respir Crit Care Med. 164:273-276.
  • Chung KF; Adcock IM. (Jul 2001). Pathophysiological mechanisms of asthma. Application of cell and molecular biology techniques. Mol Biotechnol. 18:213-232. DOI.
  • Di Stefano A; Capelli A; Lusuardi M; Caramori G; Balbo P; Ioli F; Sacco S; Gnemmi I; et alBrun P; Adcock IM; Balbi B; Barnes PJ; Chung KF; Donner CF. (Jun 2001). Decreased T lymphocyte infiltration in bronchial biopsies of subjects with severe chronic obstructive pulmonary disease. CLIN EXP ALLERGY. 31:893-902.
  • Laan M; Lotvall J; Chung KF; Linden A. (May 2001). IL-17-induced cytokine release in human bronchial epithelial cells in vitro: role of mitogen-activated protein (MAP) kinases. BRIT J PHARMACOL. 133:200-206.
  • Ito K; Lim S; Caramori G; Chung KF; Barnes PJ; Adcock IM. (Apr 2001). Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages. FASEB J. 15:1110-1112.
  • Huang TJ; MacAry PA; Eynott P; Moussavi A; Daniel KC; Askenase PW; Kemeny DM; Chung KF. (1 Jan 2001). Allergen-specific Th1 cells counteract efferent Th2 cell-dependent bronchial hyperresponsiveness and eosinophilic inflammation partly via IFN-gamma. J Immunol. 166:207-217.
  • Lazzeri N; Belvisi MG; Patel HJ; Yacoub MH; Chung KF; Mitchell JA. (Jan 2001). Effects of prostaglandin E2 and cAMP elevating drugs on GM-CSF release by cultured human airway smooth muscle cells. Relevance to asthma therapy. Am J Respir Cell Mol Biol. 24:44-48.
  • Leckie MJ; ten Brinke A; Khan J; Diamant Z; O'Connor BJ; Walls CM; Mathur AK; Cowley HC; et alChung KF; Djukanovic R; Hansel TT; Holgate ST; Sterk PJ; Barnes PJ. (23 Dec 2000). Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet. 356:2144-2148.
  • Matthews JG; Irusen E; Smith S; Stirling RG; Campbell D; Robinson DS; Chung KF; Barnes PJ; et alAdcock I; Asthma Allergy Grp. (Dec 2000). Altered steroid binding in PBMC corellates strongly with steroid in-sensitivity in patients with difficult asthma. THORAX. 55:A22-A22.
  • Ganeshalingam K; Campbell DA; Chung KF; Robinson DS. (Dec 2000). Difficult asthma patients and their quality of life. THORAX. 55:A32-A32.
  • Chung KF. (Dec 2000). Difficult, therapy-resistant asthma: definition and clinical features. Monaldi Arch Chest Dis. 55:459-465.
  • Stirling RG; Chung KF. (Dec 2000). New immunological approaches and cytokine targets in asthma and allergy. Eur Respir J. 16:1158-1174.
  • Newton R; Hart L; Chung KF; Barnes PJ. (2 Nov 2000). Ceramide induction of COX-2 and PGE(2) in pulmonary A549 cells does not involve activation of NF-kappaB. Biochem Biophys Res Commun. 277:675-679. DOI.
  • Salmon M; Liu YC; Mak JC; Rousell J; Huang TJ; Hisada T; Nicklin PL; Chung KF. (Nov 2000). Contribution of upregulated airway endothelin-1 expression to airway smooth muscle and epithelial cell DNA synthesis after repeated allergen exposure of sensitized Brown-Norway rats. Am J Respir Cell Mol Biol. 23:618-625.
  • Lim S; Groneberg D; Fischer A; Oates T; Caramori G; Mattos W; Adcock I; Barnes PJ; et alChung KF. (Nov 2000). Expression of heme oxygenase isoenzymes 1 and 2 in normal and asthmatic airways: effect of inhaled corticosteroids. Am J Respir Crit Care Med. 162:1912-1918.
  • Lim S; Roche N; Oliver BG; Mattos W; Barnes PJ; Chung KF. (Oct 2000). Balance of matrix metalloprotease-9 and tissue inhibitor of metalloprotease-1 from alveolar macrophages in cigarette smokers. Regulation by interleukin-10. Am J Respir Crit Care Med. 162:1355-1360.
  • Lim S; Jatakanon A; Gordon D; Macdonald C; Chung KF; Barnes PJ. (Oct 2000). Comparison of high dose inhaled steroids, low dose inhaled steroids plus low dose theophylline, and low dose inhaled steroids alone in chronic asthma in general practice. Thorax. 55:837-841.
  • Chung KF; Naya I. (Sep 2000). Compliance with an oral asthma medication: a pilot study using an electronic monitoring device. Respir Med. 94:852-858. DOI.
  • Hisada T; Salmon M; Nasuhara Y; Chung KF. (7 Jul 2000). Involvement of haemoxygenase-1 in ozone-induced airway inflammation and hyperresponsiveness. Eur J Pharmacol. 399:229-234.
  • Nightingale JA; Maggs R; Cullinan P; Donnelly LE; Rogers DF; Kinnersley R; Chung KF; Barnes PJ; et alAshmore M; Newman-Taylor A. (Jul 2000). Airway inflammation after controlled exposure to diesel exhaust particulates. Am J Respir Crit Care Med. 162:161-166.
  • Haddad EB; Fox AJ; Rousell J; Burgess G; McIntyre P; Barnes PJ; Chung KF. (Jun 2000). Post-transcriptional regulation of bradykinin B1 and B2 receptor gene expression in human lung fibroblasts by tumor necrosis factor-alpha: modulation by dexamethasone. Mol Pharmacol. 57:1123-1131.
  • Chung KF. (Jun 2000). Unmet needs in adult asthma. Clin Exp Allergy. 30 Suppl 1:66-69.
  • Chung KF. (May 2000). Airway smooth muscle cells: contributing to and regulating airway mucosal inflammation?. Eur Respir J. 15:961-968.
  • Lim S; John M; Seybold J; Taylor D; Witt C; Barnes PJ; Chung KF. (May 2000). Increased interleukin-10 and macrophage inflammatory protein-1 alpha release from blood monocytes ex vivo during late-phase response to allergen in asthma. Allergy. 55:489-495.
  • Lim S; Jatakanon A; Meah S; Oates T; Chung KF; Barnes PJ. (Mar 2000). Relationship between exhaled nitric oxide and mucosal eosinophilic inflammation in mild to moderately severe asthma. Thorax. 55:184-188.
  • Chung KF; Sterk PJ. (Mar 2000). The airway smooth muscle cell: a major contributor to asthma?. EUR RESPIR J. 15:438-439.
  • Nightingale JA; Rogers DF; Chung KF; Barnes PJ. (Feb 2000). No effect of inhaled budesonide on the response to inhaled ozone in normal subjects. Am J Respir Crit Care Med. 161:479-486.
  • Hart L; Lim S; Adcock I; Barnes PJ; Chung KF. (Jan 2000). Effects of inhaled corticosteroid therapy on expression and DNA-binding activity of nuclear factor kappaB in asthma. Am J Respir Crit Care Med. 161:224-231.
  • Stirling RG; Chung KF. (2000). Future treatments of allergic diseases and asthma. Br Med Bull. 56:1037-1053.
  • Chung KF; Adcock IM. (2000). Induction of nuclear factor-kappa B by exposure to ozone and inhibition by glucocorticoids. Methods Enzymol. 319:551-562.
  • Huang TJ; Haddad EB; Fox AJ; Salmon M; Jones C; Burgess G; Chung KF. (Nov 1999). Contribution of bradykinin B(1) and B(2) receptors in allergen-induced bronchial hyperresponsiveness. Am J Respir Crit Care Med. 160:1717-1723.
  • Jatakanon A; Uasuf C; Maziak W; Lim S; Chung KF; Barnes PJ. (Nov 1999). Neutrophilic inflammation in severe persistent asthma. Am J Respir Crit Care Med. 160:1532-1539.
  • Kharitonov SA; Sapienza MM; Chung KF; Barnes PJ. (Nov 1999). Prostaglandins mediate bradykinin-induced reduction of exhaled nitric oxide in asthma. Eur Respir J. 14:1023-1027.
  • Patel HJ; Belvisi MG; Donnelly LE; Yacoub MH; Chung KF; Mitchell JA. (Oct 1999). Constitutive expressions of type I NOS in human airway smooth muscle cells: evidence for an antiproliferative role. FASEB J. 13:1810-1816.
  • Pype JL; Dupont LJ; Menten P; Van Coillie E; Opdenakker G; Van Damme J; Chung KF; Demedts MG; et alVerleden GM. (Oct 1999). Expression of monocyte chemotactic protein (MCP)-1, MCP-2, and MCP-3 by human airway smooth-muscle cells - Modulation by corticosteroids and T-helper 2 cytokines. AM J RESP CELL MOL. 21:528-536.
  • Huang TJ; Macary PA; Wilke T; Kemeny DM; Chung KF. (Oct 1999). Inhibitory effects of endogenous and exogenous interferon-gamma on bronchial hyperresponsiveness, allergic inflammation and T-helper 2 cytokines in Brown-Norway rats. IMMUNOLOGY. 98:280-288.
  • Chung KF; Barnes PJ. (Sep 1999). Cytokines in asthma. Thorax. 54:825-857.
  • Huang TJ; Newton R; Haddad EB; Chung KF. (Sep 1999). Differential regulation of cytokine expression after allergen exposure of sensitized rats by cyclosporin A and corticosteroids: relationship to bronchial hyperresponsiveness. J Allergy Clin Immunol. 104:644-652.
  • Echazarreta AL; Gomez FP; Ribas J; Achaval M; Barbera JA; Roca J; Chung KF; Rodriguez-Roisin R. (Sep 1999). Effects of inhaled furosemide on platelet-activating factor challenge in mild asthma. EUR RESPIR J. 14:616-621.
  • Gomez FP; Marrades RM; Iglesia R; Roca J; Barbera JA; Chung KF; Rodriguez-Roisin RM. (Sep 1999). Gas exchange response to a PAF receptor antagonist, SR 27417A, in acute asthma: A pilot study. EUR RESPIR J. 14:622-626.
  • Salmon M; Walsh DA; Koto H; Barnes PJ; Chung KF. (Sep 1999). Repeated allergen exposure of sensitized Brown-Norway rats induces airway cell DNA synthesis and remodelling. Eur Respir J. 14:633-641.
  • Hisada T; Salmon M; Nasuhara Y; Chung KF. (Aug 1999). Cysteinyl-leukotrienes partly mediate eotaxin-induced bronchial hyperresponsiveness and eosinophilia in IL-5 transgenic mice. Am J Respir Crit Care Med. 160:571-575.
  • Hisada T; Adcock IM; Nasuhara Y; Salmon M; Huang TJ; Barnes PJ; Chung KF. (14 Jul 1999). Inhibition of ozone-induced lung neutrophilia and nuclear factor-kappaB binding activity by vitamin A in rat. Eur J Pharmacol. 377:63-68.
  • Chung KF; Patel HJ; Fadlon EJ; Rousell J; Haddad EB; Jose PJ; Mitchell J; Belvisi M. (Jul 1999). Induction of eotaxin expression and release from human airway smooth muscle cells by IL-1beta and TNFalpha: effects of IL-10 and corticosteroids. Br J Pharmacol. 127:1145-1150. DOI.
  • Salmon M; Walsh DA; Huang TJ; Barnes PJ; Leonard TB; Hay DW; Chung KF. (Jul 1999). Involvement of cysteinyl leukotrienes in airway smooth muscle cell DNA synthesis after repeated allergen exposure in sensitized Brown Norway rats. Br J Pharmacol. 127:1151-1158. DOI.
  • John M; Hirst SJ; Chung KF; Witt C. (Jun 1999). [Airway myocytes as immune effector cells in the pathogenesis of bronchial asthma. Myocyte culture as an in vitro model]. Pneumologie. 53:302-306.
  • Hisada T; Hellewell PG; Teixeira MM; Malm MG; Salmon M; Huang TJ; Chung KF. (May 1999). alpha4 integrin-dependent eotaxin induction of bronchial hyperresponsiveness and eosinophil migration in interleukin-5 transgenic mice. Am J Respir Cell Mol Biol. 20:992-1000.
  • Chung KF; Godard P; Adelroth E; Ayres J; Barnes N; Barnes P; Bel E; Burney P; et alChanez P; Connett G; Corrigan C; de Blic J; Fabbri L; Holgate ST; Ind P; Joos G; Kerstjens H; Leuenberger P; Lofdahl CG; McKenzie S; Magnussen H; Postma D; Saetta M; Salmeron S; Silverman M; Sterk P; ERS Task Force Difficult Therapy Resistant Asth. (May 1999). Difficult/therapy-resistant asthma - The need for an integrated approach to define clinical phenotypes, evaluate risk factors, understand pathophysiology and find novel therapies. EUR RESPIR J. 13:1198-1208.
  • Chung KF; Godard P; Adelroth E; Ayres J; Barnes N; Barnes P; Bel E; Burney P; et alChanez P; Connett G; Corrigan C; de Blic J; Fabbri L; Holgate ST; Ind P; Joos G; Kerstjens H; Leuenberger P; Lofdahl CG; McKenzie S; Magnussen H; Postma D; Saetta M; Salmeron S; Sterk P. (May 1999). Difficult/therapy-resistant asthma: the need for an integrated approach to define clinical phenotypes, evaluate risk factors, understand pathophysiology and find novel therapies. ERS Task Force on Difficult/Therapy-Resistant Asthma. European Respiratory Society. Eur Respir J. 13:1198-1208.
  • Huang TJ; MacAry PA; Salmon M; Wilke T; Kemeny DM; Chung KF. (Mar 1999). Adoptive transfer of ovalbumin-specific TH2 lymphocytes induce bronchial responsiveness and eosinophilia: Inhibition by ovalbumin-specific TH1 lymphocytes. AM J RESP CRIT CARE. 159:A509-A509.
  • Stirling RG; Barnes PJ; Chung KF. (Mar 1999). Atopic asthmatic monocyte CD23 and CD40 expression measured by flow cytometry is reduced by mononuclear cell separation. AM J RESP CRIT CARE. 159:A656-A656.
  • Mak LCW; Nightingale J; Lim S; Wright A; Liggett SB; Chung KF; Barnes PJ. (Mar 1999). beta(2)-adrenoceptor polymorphisms in mild a severe asthmatics. AM J RESP CRIT CARE. 159:A32-A32.
  • Patel HJ; Belvisi MG; Donnelly LE; Yacoub MH; Chung KF; Mitchell JA. (Mar 1999). Constitutive expression of nNOS in human cultured airway smooth muscle cells: Evidence for an anti-proliferative role. AM J RESP CRIT CARE. 159:A531-A531.
  • Huang TJ; MacAry PA; Kemeny DM; Chung KF. (Mar 1999). Differential effects of CD8(+) Tc1 and Tc2 lymphocytes in allergen-induced bronchial hyperresponsiveness and inflammation in Brown-Norway rats. AM J RESP CRIT CARE. 159:A231-A231.
  • Huang TJ; MacAry PA; Kemeny DM; Chung KF. (Mar 1999). Effect of CD8+ T-cell depletion on bronchial hyper-responsiveness and inflammation in sensitized and allergen-exposed Brown-Norway rats. Immunology. 96:416-423.
  • Donnelly LE; Adcock IM; Lim S; Chung KF; Barnes PJ. (Mar 1999). Effect of glucocorticosteroids on inducible nitric oxide synthase expression in human airway primary epithelial cells. AM J RESP CRIT CARE. 159:A446-A446.
  • Salmon M; Liu YC; Rousell J; Huang TJ; Hisada T; Barnes PJ; Nicklin PL; Chung KF. (Mar 1999). Endothelin-1 expression in the lungs of sensitised Brown-Norway rats after repeated allergen exposure: Contribution to increased airway smooth muscle and epithelial proliferation. AM J RESP CRIT CARE. 159:A403-A403.
  • Donnelly LE; Lim S; Chung KF; Barnes PJ. (Mar 1999). Expression of heme-oxygenase in human airway primary epithelial cells. AM J RESP CRIT CARE. 159:A218-A218.
  • Hisada T; Mak JCW; Salmon M; Barnes PJ; Chung KF. (Mar 1999). In vivo reversal of IL-1 beta-induced impairment of beta-adrenoceptor-mediated airway relaxation by steroid. AM J RESP CRIT CARE. 159:A462-A462.
  • Jatakanon A; Lalloo UG; Lim S; Chung KF; Barnes PJ. (Mar 1999). Increased neutrophils and cytokines, TNF-alpha and IL-8, in induced sputum of non-asthmatic patients with chronic dry cough. Thorax. 54:234-237.
  • Patel HJ; Belvisi MG; Fadlon EJ; Rousell J; Haddad EB; Jose PJ; Mitchell JA; Chung KF. (Mar 1999). Induction of eotaxin expression and release from human airway smooth muscle cells by IL-1 beta & TNF alpha: Effects of IL-10 and corticosteroids. AM J RESP CRIT CARE. 159:A401-A401.
  • Nightingale JA; Cullinan P; Ashmore M; Rogers DF; Chung KF; Newman-Taylor AJ; Barnes PJ. (Mar 1999). Inflammatory effects of inhaled diesel exhaust particulates in normal subjects. AM J RESP CRIT CARE. 159:A317-A317.
  • Lazzeri N; Mitchell JA; Patel HJ; Yacoub MH; Chung KF; Belvisi MG. (Mar 1999). Inhibitors of phosphodiesterase type 4 enzymes inhibit GMCSF release by cytokine treated human airway smooth muscle cells. AM J RESP CRIT CARE. 159:A395-A395.
  • Lazzeri N; Belvisi MG; Patel HJ; Yacoub MH; Chung KF; Mitchell JA. (Mar 1999). Inhibitors of phosphodiesterase type 4 enzymes inhibit RANTES release by cytokine treated human airway smooth muscle cells. AM J RESP CRIT CARE. 159:A401-A401.
  • Matthews JG; Irusen E; Chung KF; Barnes PJ; Adcock IM. (Mar 1999). P38 mitogen activated protein kinase mediates IL-2 and 4 mediated changes in glucocorticoid receptor (GR) affinity. AM J RESP CRIT CARE. 159:A337-A337.
  • Hisada T; Salmon M; Nasuhara Y; Chung KF. (Mar 1999). Role of cysteinyl-leukotrienes in eotaxin-induced bronchial hyperresponsiveness and eosinophil migration in IL-5 transgenic mice. AM J RESP CRIT CARE. 159:A404-A404.
  • Lim S; Jatakanon A; John M; Gilbey T; O'connor BJ; Chung KF; Barnes PJ. (Jan 1999). Effect of inhaled budesonide on lung function and airway inflammation. Assessment by various inflammatory markers in mild asthma. Am J Respir Crit Care Med. 159:22-30.
  • Chung KF. (1999). Non-invasive biomarkers of asthma. Pediatr Pulmonol Suppl. 18:41-44.
  • Stirling RG; Kharitonov SA; Campbell D; Robinson DS; Durham SR; Chung KF; Barnes PJ. (Dec 1998). Increase in exhaled nitric oxide levels in patients with difficult asthma and correlation with symptoms and disease severity despite treatment with oral and inhaled corticosteroids. Asthma and Allergy Group. Thorax. 53:1030-1034.
  • Barnes PJ; Chung KF; Page CP. (Dec 1998). Inflammatory mediators of asthma: an update. Pharmacol Rev. 50:515-596.
  • Hart LA; Krishnan VL; Adcock IM; Barnes PJ; Chung KF. (Nov 1998). Activation and localization of transcription factor, nuclear factor-kappaB, in asthma. Am J Respir Crit Care Med. 158:1585-1592.
  • Chung KF. (Nov 1998). Alternative treatments for difficult severe therapy-resistant asthma. REV FR ALLERGOL. 38:778-780.
  • Jatakanon A; Lim S; Chung KF; Barnes PJ. (Nov 1998). An inhaled steroid improves markers of airway inflammation in patients with mild asthma. Eur Respir J. 12:1084-1088.
  • Chung KF. (Nov 1998). Corticosteroid responsiveness and the evolution of asthma. Clin Exp Allergy. 28 Suppl 5:126-132.
  • Kharitonov SA; Sapienza MA; Barnes PJ; Chung KF. (Nov 1998). Prostaglandins E2 and F2alpha reduce exhaled nitric oxide in normal and asthmatic subjects irrespective of airway caliber changes. Am J Respir Crit Care Med. 158:1374-1378.
  • Horváth I; Donnelly LE; Kiss A; Kharitonov SA; Lim S; Chung KF; Barnes PJ. (Oct 1998). Combined use of exhaled hydrogen peroxide and nitric oxide in monitoring asthma. Am J Respir Crit Care Med. 158:1042-1046.
  • Nightingale JA; Rogers DF; Hart LA; Kharitonov SA; Chung KF; Barnes PJ. (Jul 1998). Effect of inhaled endotoxin on induced sputum in normal, atopic, and atopic asthmatic subjects. Thorax. 53:563-571.
  • Gomez FP; Iglesia R; Roca J; Barbera JA; Chung KF; Rodriguez-Roisin R. (May 1998). The effects of 5-lipoxygenase inhibition by zileuton on platelet-activating-factor-induced pulmonary abnormalities in mild asthma. AM J RESP CRIT CARE. 157:1559-1564.
  • Gomez FP; Roca J; Barbera JA; Chung KF; Peinado VI; Rodriguez-Roisin R. (Apr 1998). Effect of a platelet-activating factor (PAF) antagonist, SR 27417A, on PAF-induced gas exchange abnormalities in mild asthma. EUR RESPIR J. 11:835-839.
  • Wang CH; Liu CY; Lin HC; Yu CT; Chung KF; Kuo HP. (Apr 1998). Increased exhaled nitric oxide in active pulmonary tuberculosis due to inducible NO synthase upregulation in alveolar macrophages. EUR RESPIR J. 11:809-815.
  • Chung KF; Barnes PJ. (Apr 1998). Zafirlukast (Accolate (TM)). DRUGS TODAY. 34:375-388.
  • Chung KF; Barnes PJ. (Apr 1998). Zafirlukast (Accolate). Drugs Today (Barc). 34:375-388.
  • Sapienza MA; Kharitonov SA; Horvath I; Chung KF; Barnes PJ. (Mar 1998). Effect of inhaled L-arginine on exhaled nitric oxide in normal and asthmatic subjects. Thorax. 53:172-175.
  • Lalloo UG; Lim S; DuBois R; Barnes PJ; Chung KF. (Mar 1998). Increased sensitivity of the cough reflex in progressive systemic sclerosis patients with interstitial lung disease. EUR RESPIR J. 11:702-705.
  • Carr DH; Hibon S; Rubens M; Chung KF. (Mar 1998). Peripheral airways obstruction on high-resolution computed tomography in chronic severe asthma. Respir Med. 92:448-453.
  • Salmon M; Koto H; Lynch OT; Haddad EB; Lamb NJ; Quinlan GJ; Barnes PJ; Chung KF. (Mar 1998). Proliferation of airway epithelium after ozone exposure: effect of apocynin and dexamethasone. Am J Respir Crit Care Med. 157:970-977.
  • Jatakanon A; Lim S; Kharitonov SA; Chung KF; Barnes PJ. (Feb 1998). Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma. Thorax. 53:91-95.
  • John M; Au BT; Jose PJ; Lim S; Saunders M; Barnes PJ; Mitchell JA; Belvisi MG; et alChung KF. (Jan 1998). Expression and release of interleukin-8 by human airway smooth muscle cells: inhibition by Th-2 cytokines and corticosteroids. Am J Respir Cell Mol Biol. 18:84-90.
  • John M; Lim S; Seybold J; Jose P; Robichaud A; O'Connor B; Barnes PJ; Chung KF. (Jan 1998). Inhaled corticosteroids increase interleukin-10 but reduce macrophage inflammatory protein-1alpha, granulocyte-macrophage colony-stimulating factor, and interferon-gamma release from alveolar macrophages in asthma. Am J Respir Crit Care Med. 157:256-262.
  • Kharitonov SA; Sapienza MA; Barnes PJ; Chung KF. (Jan 1998). Prostaglandins E-2 and F-2 alpha reduce exhaled nitric oxide in normal and asthmatic subjects regardless of airway calibre changes. J ALLERGY CLIN IMMUN. 101:S34-S34.
  • Chung KF. (1998). The complementary role of glucocorticosteroids and long-acting beta-adrenergic agonists. Allergy. 53:7-13.
  • Chung KF. (Dec 1997). Platelet activating factor revisited. THORAX. 52:1019-1020.
  • Evans DJ; Taylor DA; Zetterstrom O; Chung KF; O'Connor BJ; Barnes PJ. (13 Nov 1997). A comparison of low-dose inhaled budesonide plus theophylline and high-dose inhaled budesonide for moderate asthma. N Engl J Med. 337:1412-1418. DOI.
  • Stone RA; Barnes PJ; Chung KF. (6 Aug 1997). Effect of 5-HT1A receptor agonist, 8-OH-DPAT, on cough responses in the conscious guinea pig. Eur J Pharmacol. 332:201-207.
  • Liu SF; Haddad EB; Adcock I; Salmon M; Koto H; Gilbey T; Barnes PJ; Chung KF. (Aug 1997). Inducible nitric oxide synthase after sensitization and allergen challenge of Brown Norway rat lung. Br J Pharmacol. 121:1241-1246. DOI.
  • Diaz O; Barbera JA; Marrades R; Chung KF; Roca J; RodriguezRoisin R. (Jul 1997). Inhibition of PAF-induced gas exchange defects by beta-adrenergic agonists in mild asthma is not due to bronchodilation. AM J RESP CRIT CARE. 156:17-22.
  • Koto H; Salmon M; Haddad el-B; Huang TJ; Zagorski J; Chung KF. (Jul 1997). Role of cytokine-induced neutrophil chemoattractant (CINC) in ozone-induced airway inflammation and hyperresponsiveness. Am J Respir Crit Care Med. 156:234-239.
  • Al-Kattan K; Simonds A; Chung KF; Kaplan DK. (Apr 1997). Kyphoscoliosis and bronchial torsion. Chest. 111:1134-1137.
  • John M; Hirst SJ; Jose PJ; Robichaud A; Berkman N; Witt C; Twort CH; Barnes PJ; et alChung KF. (15 Feb 1997). Human airway smooth muscle cells express and release RANTES in response to T helper 1 cytokines: regulation by T helper 2 cytokines and corticosteroids. J Immunol. 158:1841-1847.
  • Sun J; Koto H; Chung KF. (Feb 1997). Interaction of ozone and allergen challenges on bronchial responsiveness and inflammation in sensitised guinea pigs. Int Arch Allergy Immunol. 112:191-195.
  • Sun J; Chung KF. (Jan 1997). Airway inflammation despite loss of bronchial hyper-responsiveness after multiple ozone exposures. Respir Med. 91:47-55.
  • Berkman N; Krishnan VL; Gilbey T; Newton R; O'Connor B; Barnes PJ; Chung KF. (Dec 1996). Expression of RANTES mRNA and protein in airways of patients with mild asthma. Am J Respir Crit Care Med. 154:1804-1811.
  • Chung KF. (Nov 1996). Effects of nedocromil sodium on airway neurogenic mechanisms. J ALLERGY CLIN IMMUN. 98:S112-S116.
  • Laitinen LA; Myers AC; Norris AA; Widdicombe JG; Seale JP; Barnes PJ; Chung KF; Alton EWFW. (Nov 1996). Effects of nedocromil sodium on airway neurogenic mechanisms - Discussion. J ALLERGY CLIN IMMUN. 98:S116-S117.
  • Calhoun WJ; Konig P; Creticos PS; Pauwels R; Virchow JC; Beasley R; Chung KF; Bleecker RR; et alRainey DK. (Nov 1996). Effects of nedocromil sodium on inflammation and symptoms in therapeutic studies - Discussion. J ALLERGY CLIN IMMUN. 98:S149-S150.
  • Berkman N; Robichaud A; Robbins RA; Roesems G; Haddad EB; Barnes PJ; Chung KF. (Nov 1996). Inhibition of inducible nitric oxide synthase expression by interleukin-4 and interleukin-13 in human lung epithelial cells. Immunology. 89:363-367.
  • Lalloo UG; Barnes PJ; Chung KF. (Nov 1996). Pathophysiology and clinical presentations of cough. J Allergy Clin Immunol. 98:S91-S96.
  • Koto H; Mak JC; Haddad EB; Xu WB; Salmon M; Barnes PJ; Chung KF. (15 Oct 1996). Mechanisms of impaired beta-adrenoceptor-induced airway relaxation by interleukin-1beta in vivo in the rat. J Clin Invest. 98:1780-1787. DOI.
  • Chung KF; Lalloo UG. (Oct 1996). Diagnosis and management of chronic persistent dry cough. Postgrad Med J. 72:594-598.
  • Chung KF. (Oct 1996). Methods of assessing cough and antitussives in man. Pulm Pharmacol. 9:373-377.
  • Adcock IM; Gilbey T; Gelder CM; Chung KF; Barnes PJ. (Sep 1996). Glucocorticoid receptor localization in normal and asthmatic lung. Am J Respir Crit Care Med. 154:771-782.
  • Berkman N; John M; Roesems G; Jose P; Barnes PJ; Chung KF. (Sep 1996). Interleukin 13 inhibits macrophage inflammatory protein-1 alpha production from human alveolar macrophages and monocytes. Am J Respir Cell Mol Biol. 15:382-389.
  • Chua TP; Lalloo UG; Worsdell MY; Kharitonov S; Chung KF; Coats AJ. (Aug 1996). Airway and cough responsiveness and exhaled nitric oxide in non-smoking patients with stable chronic heart failure. Heart. 76:144-149.
  • Masclans JR; Barbera JA; MacNee W; Pavia J; Piera C; Lomena F; Chung KF; Roca J; et alRodriguezRoisin R. (Aug 1996). Salbutamol reduces pulmonary neutrophil sequestration of platelet-activating factor in humans. AM J RESP CRIT CARE. 154:529-532.
  • Kharitonov SA; Chung KF; Evans D; O'Connor BJ; Barnes PJ. (Jun 1996). Increased exhaled nitric oxide in asthma is mainly derived from the lower respiratory tract. Am J Respir Crit Care Med. 153:1773-1780.
  • Chung KF. (May 1996). Airway neuropeptides and neutral endopeptidase in asthma. CLIN EXP ALLERGY. 26:491-493.
  • Gelder CM; Barnes PJ; O'Connor BJ; Chung KF; Adcock IM. (May 1996). Cytokine mRNA profiles of normal and asthmatic peripheral blood cells and endobronchial biopsies. Biochem Soc Trans. 24:315S.
  • Gelder CM; Morrison JF; Chung KF; Barnes PJ; Adcock IM. (May 1996). T cell receptor repertoire in peripheral blood and bronchial biopsies from normal and asthmatic subjects. Biochem Soc Trans. 24:316S.
  • Berkman N; Robichaud A; Krishnan VL; Roesems G; Robbins R; Jose PJ; Barnes PJ; Chung KF. (Apr 1996). Expression of RANTES in human airway epithelial cells: effect of corticosteroids and interleukin-4, -10 and -13. Immunology. 87:599-603.
  • Gutteridge JM; Mumby S; Quinlan GJ; Chung KF; Evans TW. (27 Mar 1996). Pro-oxidant iron is present in human pulmonary epithelial lining fluid: implications for oxidative stress in the lung. Biochem Biophys Res Commun. 220:1024-1027. DOI.
  • Sakamoto T; Barnes PJ; Chung KF. (Mar 1996). Lack of a role for bradykinin in allergen-induced airway microvascular leakage and bronchoconstriction in the guinea pig. Inflamm Res. 45:123-126.
  • Haddad EB; Salmon M; Koto H; Barnes PJ; Adcock I; Chung KF. (5 Feb 1996). Ozone induction of cytokine-induced neutrophil chemoattractant (CINC) and nuclear factor-kappa b in rat lung: inhibition by corticosteroids. FEBS Lett. 379:265-268.
  • Kharitonov SA; Yates DH; Chung KF; Barnes PJ. (Feb 1996). Changes in the dose of inhaled steroid affect exhaled nitric oxide levels in asthmatic patients. Eur Respir J. 9:196-201.
  • Kidney JC; Lotvall JO; Lei Y; Chung KF; Barnes PJ. (18 Jan 1996). The effect of inhaled K+ channel openers on bronchoconstriction and airway microvascular leakage in anaesthetised guinea pigs. Eur J Pharmacol. 296:81-87.
  • Yates DH; O'Connor BJ; Yilmaz G; Aikman S; Worsdell M; Barnes PJ; Chung KF. (Dec 1995). Effect of acute and chronic inhaled furosemide on bronchial hyperresponsiveness in mild asthma. Am J Respir Crit Care Med. 152:2173-2175.
  • Cambrey AD; Kwon OJ; Gray AJ; Harrison NK; Yacoub M; Barnes PJ; Laurent GJ; Chung KF. (Dec 1995). Insulin-like growth factor I is a major fibroblast mitogen produced by primary cultures of human airway epithelial cells. Clin Sci (Lond). 89:611-617.
  • Xu WB; Haddad EB; Tsukagoshi H; Adcock I; Barnes PJ; Chung KF. (Nov 1995). Induction of macrophage inflammatory protein 2 gene expression by interleukin 1 beta in rat lung. Thorax. 50:1136-1140.
  • Berkman N; John M; Roesems G; Jose PJ; Barnes PJ; Chung KF. (1 Nov 1995). Inhibition of macrophage inflammatory protein-1 alpha expression by IL-10. Differential sensitivities in human blood monocytes and alveolar macrophages. J Immunol. 155:4412-4418.
  • Haddad EB; Liu SF; Salmon M; Robichaud A; Barnes PJ; Chung KF. (6 Oct 1995). Expression of inducible nitric oxide synthase mRNA in Brown Norway rats exposed to ozone: effect of dexamethasone. Eur J Pharmacol. 293:287-290.
  • Lalloo UG; Fox AJ; Belvisi MG; Chung KF; Barnes PJ. (Oct 1995). Capsazepine inhibits cough induced by capsaicin and citric acid but not by hypertonic saline in guinea pigs. J Appl Physiol. 79:1082-1087.
  • Berkman N; Jose PJ; Williams TJ; Schall TJ; Barnes PJ; Chung KF. (Oct 1995). Corticosteroid inhibition of macrophage inflammatory protein-1 alpha in human monocytes and alveolar macrophages. Am J Physiol. 269:L443-L452.
  • Haczku A; Chung KF; Sun J; Barnes PJ; Kay AB; Moqbel R. (Aug 1995). Airway hyperresponsiveness, elevation of serum-specific IgE and activation of T cells following allergen exposure in sensitized Brown-Norway rats. Immunology. 85:598-603.
  • Sun J; Sakamoto T; Chung KF. (Aug 1995). Effects of sodium metabisulphite on guinea pig contractile airway smooth muscle responses in vitro. Thorax. 50:875-879.
  • Haczku A; Moqbel R; Jacobson M; Kay AB; Barnes PJ; Chung KF. (Aug 1995). T-cells subsets and activation in bronchial mucosa of sensitized Brown-Norway rats after single allergen exposure. Immunology. 85:591-597.
  • Chung KF. (Jul 1995). Leukotriene receptor antagonists and biosynthesis inhibitors: potential breakthrough in asthma therapy. Eur Respir J. 8:1203-1213.
  • Tsukagoshi H; Haddad EB; Barnes PJ; Chung KF. (Jun 1995). Bradykinin receptor subtypes in rat lung: effect of interleukin-1 beta. J Pharmacol Exp Ther. 273:1257-1263.
  • Kidney J; Dominguez M; Taylor PM; Rose M; Chung KF; Barnes PJ. (Jun 1995). Immunomodulation by theophylline in asthma. Demonstration by withdrawal of therapy. Am J Respir Crit Care Med. 151:1907-1914.
  • Munyard P; Chung KF; Bush A. (Jun 1995). Inhaled frusemide and exercise-induced bronchoconstriction in children with asthma. Thorax. 50:677-679.
  • ROCA J; FELEZ MA; CHUNG KF; BARBERA JA; ROTGER M; SANTOS C; RODRIGUEZROISIN R. (Jun 1995). SALBUTAMOL INHIBITS PULMONARY EFFECTS OF PLATELET-ACTIVATING-FACTOR IN MAN. AM J RESP CRIT CARE. 151:1740-1744.
  • Tsukagoshi H; Haddad EB; Sun J; Barnes PJ; Chung KF. (Mar 1995). Ozone-induced airway hyperresponsiveness: role of superoxide anions, NEP, and BK receptors. J Appl Physiol. 78:1015-1022.
  • Tsukagoshi H; Sun J; Kwon O; Barnes PJ; Chung KF. (Mar 1995). Role of neutral endopeptidase in bronchial hyperresponsiveness to bradykinin induced by IL-1 beta. J Appl Physiol. 78:921-927.
  • Harrison NK; Dawes KE; Kwon OJ; Barnes PJ; Laurent GJ; Chung KF. (Feb 1995). Effects of neuropeptides on human lung fibroblast proliferation and chemotaxis. Am J Physiol. 268:L278-L283.
  • Elwood W; Sun J; Barnes PJ; Giembycz MA; Chung KF. (Feb 1995). Inhibition of allergen-induced lung eosinophilia by type-III and combined type III- and IV-selective phosphodiesterase inhibitors in brown-Norway rats. Inflamm Res. 44:83-86.
  • O'Connor BJ; Yeo CT; Chen-Worsdell YM; Barnes PJ; Chung KF. (Nov 1994). Effect of acetazolamide and amiloride against sodium metabisulphite-induced bronchoconstriction in mild asthma. Thorax. 49:1096-1098.
  • Tsukagoshi H; Robbins RA; Barnes PJ; Chung KF. (Oct 1994). Role of nitric oxide and superoxide anions in interleukin-1 beta-induced airway hyperresponsiveness to bradykinin. Am J Respir Crit Care Med. 150:1019-1025.
  • Kwon OJ; Au BT; Collins PD; Adcock IM; Mak JC; Robbins RR; Chung KF; Barnes PJ. (Oct 1994). Tumor necrosis factor-induced interleukin-8 expression in cultured human airway epithelial cells. Am J Physiol. 267:L398-L405.
  • FELEZ MA; ROCA J; BARBERA JA; SANTOS C; ROTGER M; CHUNG KF; RODRIGUEZROISIN R. (Aug 1994). INHALED PLATELET-ACTIVATING-FACTOR WORSENS GAS-EXCHANGE IN MILD ASTHMA. AM J RESP CRIT CARE. 150:369-373.
  • Sun J; Elwood W; Haczku A; Barnes PJ; Hellewell PG; Chung KF. (Jul 1994). Contribution of intercellular-adhesion molecule-1 in allergen-induced airway hyperresponsiveness and inflammation in sensitised brown-Norway rats. Int Arch Allergy Immunol. 104:291-295.
  • Hsu JY; Stone RA; Logan-Sinclair RB; Worsdell M; Busst CM; Chung KF. (Jul 1994). Coughing frequency in patients with persistent cough: assessment using a 24 hour ambulatory recorder. Eur Respir J. 7:1246-1253.
  • Haczku A; Moqbel R; Elwood W; Sun J; Kay AB; Barnes PJ; Chung KF. (Jul 1994). Effects of prolonged repeated exposure to ovalbumin in sensitized brown Norway rats. Am J Respir Crit Care Med. 150:23-27.
  • O'Connor BJ; Uden S; Carty TJ; Eskra JD; Barnes PJ; Chung KF. (Jul 1994). Inhibitory effect of UK,74505, a potent and specific oral platelet activating factor (PAF) receptor antagonist, on airway and systemic responses to inhaled PAF in humans. Am J Respir Crit Care Med. 150:35-40.
  • O'Connor BJ; Barnes PJ; Chung KF. (Apr 1994). Inhibition of sodium metabisulphite induced bronchoconstriction by frusemide in asthma: role of cyclooxygenase products. Thorax. 49:307-311.
  • Nichol GM; Parsons GH; Chung KF. (Mar 1994). Effect of sodium metabisulphite on bronchial blood flow in conscious sheep: pharmacological modulation. Br J Pharmacol. 111:918-922.
  • Kwon OJ; Au BT; Collins PD; Baraniuk JN; Adcock IM; Chung KF; Barnes PJ. (Mar 1994). Inhibition of interleukin-8 expression by dexamethasone in human cultured airway epithelial cells. Immunology. 81:389-394.
  • CHUNG KF. (2 Feb 1994). MANAGEMENT OF DIFFICULT ASTHMA. BRIT J HOSP MED. 51:80-81.
  • Tsukagoshi H; Sakamoto T; Xu W; Barnes PJ; Chung KF. (Feb 1994). Effect of interleukin-1 beta on airway hyperresponsiveness and inflammation in sensitized and nonsensitized Brown-Norway rats. J Allergy Clin Immunol. 93:464-469.
  • Sakamoto T; Tsukagoshi H; Barnes PJ; Chung KF. (Feb 1994). Involvement of tachykinin receptors (NK1 and NK2) in sodium metabisulfite-induced airway effects. Am J Respir Crit Care Med. 149:387-391.
  • Sakamoto T; Sun J; Barnes PJ; Chung KF. (14 Jan 1994). Effect of a bradykinin receptor antagonist, HOE 140, against bradykinin- and vagal stimulation-induced airway responses in the guinea-pig. Eur J Pharmacol. 251:137-142.
  • Chung KF. (1994). Furosemide and other diuretics in asthma. J Asthma. 31:85-92.
  • RODRIGUEZROISIN R; FELEZ MA; CHUNG KF; BARBERA JA; WAGNER PD; COBOS A; BARNES PJ; ROCA J. (Jan 1994). PLATELET-ACTIVATING-FACTOR CAUSES VENTILATION-PERFUSION MISMATCH IN HUMANS. J CLIN INVEST. 93:188-194.
  • Elwood W; Sakamoto T; Barnes PJ; Chung KF. (1994). Role of cyclooxygenase and 5-lipoxygenase metabolites, platelet-activating factor and 5-hydroxytryptamine in allergen-induced airway responses in the brown Norway rat. Int Arch Allergy Immunol. 103:67-72.
  • CHUNG KF. (Dec 1993). THE CURRENT DEBATE CONCERNING BETA-AGONISTS IN ASTHMA - REPLY. J ROY SOC MED. 86:743-744.
  • Sun J; Elwood W; Barnes PJ; Chung KF. (Oct 1993). Effect of thiazide diuretics against neurally mediated contraction of guinea pig airways. Contribution of carbonic anhydrase. Am Rev Respir Dis. 148:902-908.
  • Sakamoto T; Barnes PJ; Chung KF. (Sep 1993). Effect of beta 2-adrenoceptor agonists against platelet-activating factor-induced airway microvascular leakage and bronchoconstriction in the guinea pig. Agents Actions. 40:50-56.
  • Elwood W; Sakamoto T; Barnes PJ; Chung KF. (Jul 1993). Allergen-induced airway hyperresponsiveness in Brown-Norway rat: role of parasympathetic mechanisms. J Appl Physiol. 75:279-284.
  • Sakamoto T; Tsukagoshi H; Barnes PJ; Chung KF. (Jul 1993). Role played by NK2 receptor and cyclooxygenase activation in bradykinin B2 receptor mediated-airway effects in guinea pigs. Agents Actions. 39:111-117.
  • Stone RA; Barnes PJ; Chung KF. (Jun 1993). Effect of frusemide on cough responses to chloride-deficient solution in normal and mild asthmatic subjects. Eur Respir J. 6:862-867.
  • HSU JY; STONE RA; LOGANSINCLAIR R; BUSST C; CHUNG KF. (Apr 1993). AMBULATORY 24-HOUR COUGH RECORDER TO MEASURE COUGHING EVENTS IN ASTHMA AND IN PERSISTENT COUGH OF UNKNOWN CAUSE. AM REV RESPIR DIS. 147:A997-A997.
  • SAKAMOTO T; SUN J; BARNES PJ; CHUNG KF. (Apr 1993). EFFECT OF INHALED HOE-140, A BRADYKININ RECEPTOR ANTAGONIST, AGAINST BRADYKININ-INDUCED AND VAGUS NERVE STIMULATION-INDUCED AIRWAY RESPONSES IN GUINEA-PIGS. AM REV RESPIR DIS. 147:A477-A477.
  • SAKAMOTO T; TSUKAGOSHI H; BARNES PJ; CHUNG KF. (Apr 1993). ROLE PLAYED BY TACHYKININ NK-1 AND NK-2 RECEPTOR ACTIVATION IN METABISULFITE-INDUCED BRONCHOCONSTRICTION AND AIRWAY MICROVASCULAR LEAKAGE IN GUINEA-PIGS. AM REV RESPIR DIS. 147:A706-A706.
  • Kroegel C; Dewar A; Yukawa T; Venge P; Barnes PJ; Chung KF. (Apr 1993). Ultrastructural characterization of platelet-activating factor-stimulated human eosinophils from patients with asthma. Clin Sci (Lond). 84:391-399.
  • Elwood W; Lötvall JO; Barnes PJ; Chung KF. (Mar 1993). Airway hyperresponsiveness to acetylcholine and to tachykinins after respiratory virus infection in the guinea pig. Ann Allergy. 70:231-236.
  • Sakamoto T; Elwood W; Barnes PJ; Chung KF. (Mar 1993). Effect of inhaled lyso-platelet-activating factor on airway microvascular leakage in the guinea pig. J Appl Physiol. 74:1117-1122.
  • Kidney JC; Fuller RW; Worsdell YM; Lavender EA; Chung KF; Barnes PJ. (Feb 1993). Effect of an oral potassium channel activator, BRL 38227, on airway function and responsiveness in asthmatic patients: comparison with oral salbutamol. Thorax. 48:130-133.
  • Evans PM; O'Connor BJ; Fuller RW; Barnes PJ; Chung KF. (Feb 1993). Effect of inhaled corticosteroids on peripheral blood eosinophil counts and density profiles in asthma. J Allergy Clin Immunol. 91:643-650.
  • Chung KF. (Feb 1993). The current debate concerning beta-agonists in asthma: a review. J R Soc Med. 86:96-100.
  • Sakamoto T; Barnes PJ; Chung KF. (26 Jan 1993). Effect of CP-96,345, a non-peptide NK1 receptor antagonist, against substance P-, bradykinin- and allergen-induced airway microvascular leakage and bronchoconstriction in the guinea pig. Eur J Pharmacol. 231:31-38.
  • Kidney JC; Ridge SM; Chung KF; Barnes PJ. (Jan 1993). Inhibition of platelet-activating factor-induced bronchoconstriction by the leukotriene D4 receptor antagonist ICI 204,219. Am Rev Respir Dis. 147:215-217.
  • Hayes JP; Chung KF; Barnes PJ. (Nov 1992). Attenuation of platelet-activating factor induced bronchoconstriction by nedocromil sodium. Eur Respir J. 5:1193-1196.
  • Hayes JP; Daniel R; Tee RD; Barnes PJ; Taylor AJ; Chung KF. (Nov 1992). Bronchial hyperreactivity after inhalation of trimellitic anhydride dust in guinea pigs after intradermal sensitization to the free hapten. Am Rev Respir Dis. 146:1311-1314.
  • Hayes JP; Lotvall JO; Baraniuk J; Daniel R; Barnes PJ; Taylor AJ; Chung KF. (Nov 1992). Bronchoconstriction and airway microvascular leakage in guinea pigs sensitized with trimellitic anhydride. Am Rev Respir Dis. 146:1306-1310.
  • YEO CT; OCONNOR BJ; CHENWORSDELL M; BARNES PJ; CHUNG KF. (Nov 1992). PROTECTIVE EFFECT OF LOOP DIURETICS, PIRETANIDE AND FRUSEMIDE, AGAINST SODIUM METABISULFITE-INDUCED BRONCHOCONSTRICTION IN ASTHMA. EUR RESPIR J. 5:1184-1188.
  • Sakamoto T; Elwood W; Barnes PJ; Chung KF. (Oct 1992). Pharmacological modulation of inhaled sodium metabisulphite-induced airway microvascular leakage and bronchoconstriction in the guinea-pig. Br J Pharmacol. 107:481-487.
  • CHUNG KF. (Sep 1992). LONG-TERM INHALED CORTICOSTEROID-THERAPY IN CHRONIC AIRWAYS OBSTRUCTION. EUR RESPIR J. 5:913-914.
  • WELLS AU; CHUNG KF; STAMP TCB; STUDD JW; BARNES PJ; DENISON DM; MITCHELL DN; GEDDES DM. (15 Aug 1992). BROMPTON GRAND ROUND - CORTICOSTEROID INDUCED OSTEOPOROSIS IN SEVERE MENSTRUAL ASTHMA. BRIT MED J. 305:413-415.
  • Hayes JP; Lotvall JO; Barnes PJ; Newman Taylor AJ; Chung KF. (Aug 1992). Involvement of inflammatory mediators in the airway responses to trimellitic anhydride in sensitized guinea-pigs. Br J Pharmacol. 106:828-832.
  • CHUNG KF. (Aug 1992). PLATELET-ACTIVATING-FACTOR IN INFLAMMATION AND PULMONARY DISORDERS. CLIN SCI. 83:127-138.
  • Hayes JP; Daniel R; Tee RD; Barnes PJ; Chung KF; Newman Taylor AJ. (Jul 1992). Specific immunological and bronchopulmonary responses following intradermal sensitization to free trimellitic anhydride in guinea pigs. Clin Exp Allergy. 22:694-700.
  • Perkins RS; Dent G; Chung KF; Barnes PJ. (9 Jun 1992). The effect of anion transport inhibitors and extracellular Cl- concentration on eosinophil respiratory burst activity. Biochem Pharmacol. 43:2480-2483.
  • Lötvall J; Elwood W; Tokuyama K; Sakamoto T; Barnes PJ; Chung KF. (Jun 1992). A thromboxane mimetic, U-46619, produces plasma exudation in airways of the guinea pig. J Appl Physiol. 72:2415-2419.
  • Elwood W; Lötvall JO; Barnes PJ; Chung KF. (Jun 1992). Effect of dexamethasone and cyclosporin A on allergen-induced airway hyperresponsiveness and inflammatory cell responses in sensitized Brown-Norway rats. Am Rev Respir Dis. 145:1289-1294.
  • VENTRESCA PG; NICHOL GM; BARNES PJ; CHUNG KF. (May 1992). EFFECT OF FRUSEMIDE ON THE INDUCTION AND POTENTIATION OF COUGH INDUCED BY PROSTAGLANDIN-F2-ALPHA. BRIT J CLIN PHARMACO. 33:514-516.
  • Hui KP; Ventresca P; Brown AC; Barnes PJ; Chung KF. (May 1992). Modulation of neurally mediated airway microvascular leakage in guinea-pig airways by beta 2-adrenoceptor agonists. Agents Actions. 36:29-32.
  • Sakamoto T; Elwood W; Barnes PJ; Chung KF. (31 Mar 1992). Effect of Hoe 140, a new bradykinin receptor antagonist, on bradykinin- and platelet-activating factor-induced bronchoconstriction and airway microvascular leakage in guinea pig. Eur J Pharmacol. 213:367-373.
  • MADDEN BP; HODSON ME; YACOUB MH; ALTON EWFW; BARNES PJ; DENISON DM; KAY AB; NEWMANTAYLOR A; et alGEDDES DM; CHUNG KF. (28 Mar 1992). ROYAL-BROMPTON GRAND ROUNDS - HEART-LUNG TRANSPLANTATION FOR CYSTIC-FIBROSIS. BRIT MED J. 304:835-836.
  • SAKAMOTO T; ELWOOD W; BARNES PJ; CHUNG KF. (Mar 1992). EVALUATION OF A BRADYKININ ANTAGONIST (HOE-140) AGAINST BRADYKININ AND PLATELET-ACTIVATING-FACTOR INDUCED AIRWAY RESPONSES IN THE GUINEA-PIG. THORAX. 47:P241-P241.
  • CHUNG KF; GEDDES DM; SHINER RJ. (Mar 1992). METHOTREXATE - DOES IT TREAT OR INDUCE ASTHMA. AM REV RESPIR DIS. 145:733-733.
  • OCONNOR BJ; YEO CT; CHENWORSDELL YM; BARNES PJ; CHUNG KF. (Mar 1992). SODIUM METABISULFITE INDUCED BRONCHOCONSTRICTION IS ATTENUATED BY A CARBONIC-ANHYDRASE INHIBITOR. THORAX. 47:P234-P234.
  • Chung KF. (29 Feb 1992). Mechanisms of bronchial inflammation in asthma: implications for therapy. Schweiz Med Wochenschr. 122:288-293.
  • DAVISON A; MULVEY D; GREEN M; CURRIE D; DENISON DM; CLARK T; CHUNG KF; GEDDES D. (22 Feb 1992). ROYAL BROMPTON GRAND ROUNDS - IDIOPATHIC DIAPHRAGMATIC WEAKNESS. BRIT MED J. 304:492-494.
  • LAMMERS JWJ; BARNES PJ; CHUNG KF. (Feb 1992). NONADRENERGIC, NONCHOLINERGIC AIRWAY INHIBITORY NERVES. EUR RESPIR J. 5:239-246.
  • Elwood W; Barnes PJ; Chung KF. (1992). Airway hyperresponsiveness is associated with inflammatory cell infiltration in allergic brown-Norway rats. Int Arch Allergy Immunol. 99:91-97.
  • Chung KF; Durham SR. (Jan 1992). Asthma as an inflammatory disease: clinical perspectives. Br Med Bull. 48:179-189.
  • Nichol GM; O'Connor BJ; Lecomte JM; Chung KF; Barnes PJ. (1992). Effect of neutral endopeptidase inhibitor on airway function and bronchial responsiveness in asthmatic subjects. Eur J Clin Pharmacol. 42:491-494.
  • Chung KF; Barnes PJ. (1992). Loop diuretics and asthma. Pulm Pharmacol. 5:1-7.
  • Lötvall J; Rabe K; Tokuyama K; Löfdahl CG; Barnes PJ; Chung KF. (Jan 1992). Neutrophil influx into guinea-pig airway lumen during cholinergic and non-cholinergic bronchoconstriction. Acta Physiol Scand. 144:101-106.
  • Barnes PJ; Chung KF. (Jan 1992). Questions about inhaled beta 2-adrenoceptor agonists in asthma. Trends Pharmacol Sci. 13:20-23.
  • Chung KF; Barnes PJ. (Jan 1992). Role of inflammatory mediators in asthma. Br Med Bull. 48:135-148.
  • Elwood W; Lötvall JO; Barnes PJ; Chung KF. (Dec 1991). Characterization of allergen-induced bronchial hyperresponsiveness and airway inflammation in actively sensitized brown-Norway rats. J Allergy Clin Immunol. 88:951-960.
  • Lötvall JO; Elwood W; Tokuyama K; Barnes PJ; Chung KF. (Dec 1991). Differential effects of phosphoramidon on neurokinin A- and substance P-induced airflow obstruction and airway microvascular leakage in guinea-pig. Br J Pharmacol. 104:945-949.
  • Tokuyama K; Lötvall JO; Morikawa A; Barnes PJ; Chung KF. (Nov 1991). Role of thromboxane A2 in airway microvascular leakage induced by inhaled platelet-activating factor. J Appl Physiol. 71:1729-1734.
  • Snashall PD; Chung KF. (Oct 1991). Airway obstruction and bronchial hyperresponsiveness in left ventricular failure and mitral stenosis. Am Rev Respir Dis. 144:945-956.
  • Shock A; Rabe KF; Dent G; Chambers RC; Gray AJ; Chung KF; Barnes PJ; Laurent GJ. (Oct 1991). Eosinophils adhere to and stimulate replication of lung fibroblasts 'in vitro'. Clin Exp Immunol. 86:185-190.
  • Lötvall JO; Tokuyama K; Barnes PJ; Chung KF. (6 Aug 1991). Bradykinin-induced airway microvascular leakage is potentiated by captopril and phosphoramidon. Eur J Pharmacol. 200:211-217.
  • HAYES JP; RIDGE SM; GRIFFITH S; BARNES PJ; CHUNG KF. (Jul 1991). INHIBITION OF CUTANEOUS AND PLATELET RESPONSES TO PLATELET-ACTIVATING-FACTOR BY ORAL WEB 2086 IN MAN. J ALLERGY CLIN IMMUN. 88:83-88.
  • O'Connor BJ; Chung KF; Chen-Worsdell YM; Fuller RW; Barnes PJ. (Jun 1991). Effect of inhaled furosemide and bumetanide on adenosine 5'-monophosphate- and sodium metabisulfite-induced bronchoconstriction in asthmatic subjects. Am Rev Respir Dis. 143:1329-1333.
  • Elwood W; Lötvall JO; Barnes PJ; Chung KF. (Jun 1991). Loop diuretics inhibit cholinergic and noncholinergic nerves in guinea pig airways. Am Rev Respir Dis. 143:1340-1344.
  • Chung KF; Podgorski MR; Goulding NJ; Godolphin JL; Sharland PR; O'Connor B; Flower RJ; Barnes PJ. (Mar 1991). Circulating autoantibodies to recombinant lipocortin-1 in asthma. Respir Med. 85:121-124.
  • Lötvall JO; Elwood W; Tokuyama K; Barnes PJ; Chung KF. (Mar 1991). Plasma exudation into airways induced by inhaled platelet-activating factor: effect of peptidase inhibition. Clin Sci (Lond). 80:241-247.
  • Lötvall JO; Hui KP; Löfdahl CG; Barnes PJ; Chung KF. (Feb 1991). Capsaicin pretreatment does not inhibit allergen-induced airway microvascular leakage in guinea pig. Allergy. 46:105-108.
  • LOFDAHL CG; CHUNG KF. (Feb 1991). LONG-ACTING BETA-2-ADRENOCEPTOR AGONISTS - A NEW PERSPECTIVE IN THE TREATMENT OF ASTHMA. EUR RESPIR J. 4:218-226.
  • Tokuyama K; Lötvall JO; Löfdahl CG; Barnes PJ; Chung KF. (25 Jan 1991). Inhaled formoterol inhibits histamine-induced airflow obstruction and airway microvascular leakage. Eur J Pharmacol. 193:35-39.
  • Rabe KF; Chung KF. (Jan 1991). The challenge of long-acting beta-adrenoceptor agonists. Respir Med. 85:5-9.
  • Lötvall JO; Skoogh BE; Lemen RJ; Elwood W; Barnes PJ; Chung KF. (Dec 1990). Bronchoconstriction induced by inhaled sodium metabisulfite in the guinea pig. Effect of capsaicin pretreatment and of neutral endopeptidase inhibition. Am Rev Respir Dis. 142:1390-1395.
  • Barnes PJ; Boschetto P; Rogers DF; Belvisi M; Roberts N; Chung KF; Evans TW. (Dec 1990). Effects of treatment on airway microvascular leakage. Eur Respir J Suppl. 12:663s-670s.
  • Lötvall JO; Lemen RJ; Hui KP; Barnes PJ; Chung KF. (Oct 1990). Airflow obstruction after substance P aerosol: contribution of airway and pulmonary edema. J Appl Physiol. 69:1473-1478.
  • Nichol GM; Alton EW; Nix A; Geddes DM; Chung KF; Barnes PJ. (Sep 1990). Effect of inhaled furosemide on metabisulfite- and methacholine-induced bronchoconstriction and nasal potential difference in asthmatic subjects. Am Rev Respir Dis. 142:576-580.
  • Chung KF. (Sep 1990). Mediators of bronchial hyperresponsiveness. Clin Exp Allergy. 20:453-458.
  • Nichol G; Nix A; Barnes PJ; Chung KF. (Sep 1990). Prostaglandin F2 alpha enhancement of capsaicin induced cough in man: modulation by beta 2 adrenergic and anticholinergic drugs. Thorax. 45:694-698.
  • Ventresca PG; Nichol GM; Barnes PJ; Chung KF. (Jul 1990). Inhaled furosemide inhibits cough induced by low chloride content solutions but not by capsaicin. Am Rev Respir Dis. 142:143-146.
  • Yukawa T; Ukena D; Kroegel C; Chanez P; Dent G; Chung KF; Barnes PJ. (Jun 1990). Beta 2-adrenergic receptors on eosinophils. Binding and functional studies. Am Rev Respir Dis. 141:1446-1452.
  • Lötvall JO; Skoogh BE; Barnes PJ; Chung KF. (May 1990). Effects of aerosolised substance P on lung resistance in guinea-pigs: a comparison between inhibition of neutral endopeptidase and angiotensin-converting enzyme. Br J Pharmacol. 100:69-72.
  • Yukawa T; Read RC; Kroegel C; Rutman A; Chung KF; Wilson R; Cole PJ; Barnes PJ. (Apr 1990). The effects of activated eosinophils and neutrophils on guinea pig airway epithelium in vitro. Am J Respir Cell Mol Biol. 2:341-353.
  • Nix A; Nichol GM; Robson A; Barnes PJ; Chung KF. (Mar 1990). Effect of formoterol, a long-lasting beta 2-adrenoceptor agonist, against methacholine-induced bronchoconstriction. Br J Clin Pharmacol. 29:321-324.
  • Evans TW; Rogers DF; Belvisi MG; Rohde JA; Chung KF; Barnes PJ. (Mar 1990). Endotoxin-induced plasma exudation in guinea-pig airways in vivo and the effect of neutrophil depletion. Eur Respir J. 3:299-303.
  • Chung KF; Rogers DF; Barnes PJ; Evans TW. (Mar 1990). The role of increased airway microvascular permeability and plasma exudation in asthma. Eur Respir J. 3:329-337.
  • Chung KF. (1990). Pharmacology of airway inflammation in asthma. Lung. 168 Suppl:132-141.
  • Nichol GM; Nix A; Chung KF; Barnes PJ. (Dec 1989). Characterisation of bronchoconstrictor responses to sodium metabisulphite aerosol in atopic subjects with and without asthma. Thorax. 44:1009-1014.
  • Barnes PJ; Chung KF. (16 Sep 1989). Difficult asthma. BMJ. 299:695-698.
  • Chung KF; Cuss FM; Barnes PJ. (Sep 1989). Platelet activating factor: effects on bronchomotor tone and bronchial responsiveness in human beings. Allergy Proc. 10:333-337.
  • Lammers JW; Minette P; McCusker MT; Chung KF; Barnes PJ. (Aug 1989). Capsaicin-induced bronchodilation in mild asthmatic subjects: possible role of nonadrenergic inhibitory system. J Appl Physiol. 67:856-861.
  • McCusker MT; Chung KF; Roberts NM; Barnes PJ. (Jun 1989). Effect of topical capsaicin on the cutaneous responses to inflammatory mediators and to antigen in man. J Allergy Clin Immunol. 83:1118-1124.
  • Seddon DJ; Chung KF; Paradinas FJ; Newlands ES; Snashall PD. (Jun 1989). Long term survival after treatment of disseminated T cell lymphoma presenting with tracheal obstruction in a patient with coeliac disease. Thorax. 44:519-520.
  • Kroegel C; Yukawa T; Dent G; Venge P; Chung KF; Barnes PJ. (15 May 1989). Stimulation of degranulation from human eosinophils by platelet-activating factor. J Immunol. 142:3518-3526.
  • Chung KF; Barnes PJ. (Feb 1989). Effects of platelet activating factor on airway calibre, airway responsiveness, and circulating cells in asthmatic subjects. Thorax. 44:108-115.
  • Chung KF; Dent G; Barnes PJ. (Feb 1989). Effects of salbutamol on bronchoconstriction, bronchial hyperresponsiveness, and leucocyte responses induced by platelet activating factor in man. Thorax. 44:102-107.
  • Chung KF; Jeyasingh K; Snashall PD. (Dec 1988). Influence of airway calibre on the intrapulmonary dose and distribution of inhaled aerosol in normal and asthmatic subjects. Eur Respir J. 1:890-895.
  • Snashall PD; Gillett MK; Chung KF. (Feb 1988). Factors contributing to bronchial hyper-responsiveness in asthma. Clin Sci (Lond). 74:113-118.
  • Chung KF; Jones P; Keyes SJ; Morgan BM; Snashall PD. (Jul 1987). Vagal control of end-expiratory lung volume in anaesthetized dogs. Bull Eur Physiopathol Respir. 23:353-358.
  • CHUNG KF; SNASHALL PD. (1984). EFFECT OF PRIOR BRONCHOCONSTRICTION ON THE AIRWAY RESPONSE TO HISTAMINE IN NORMAL SUBJECTS. THORAX. 39:40-45.
  • CHUNG KF; SNASHALL PD. (1984). METHACHOLINE DOSE-RESPONSE CURVES IN NORMAL AND ASTHMATIC MAN - EFFECT OF STARTING CONDUCTANCE AND PHARMACOLOGICAL ANTAGONISM. CLIN SCI. 66:665-673.
  • CHUNG KF; ALAGHBANDZADEH J; GUZ A. (1983). ACROMEGALY AND HYPERPROLACTINEMIA IN MCCUNE-ALBRIGHT SYNDROME - EVIDENCE OF HYPOTHALAMIC DYSFUNCTION. AM J DIS CHILD. 137:134-136.
  • CHUNG KF; MORGAN BM; SNASHALL PD. (1983). EFFECTS OF PHARMACOLOGIC ANTAGONIST ACTIVITY AND BRONCHODILATATION ON THE BRONCHIAL DOSE-RESPONSE CURVE TO METHACHOLINE. CLIN SCI. 64:P49-P49.
  • CHUNG KF; SNASHALL PD; JEYASINGH K. (1983). INFLUENCE OF AIRWAY CALIBER ON AEROSOL DEPOSITION IN NORMAL AND ASTHMATIC AIRWAYS - RELATIONSHIP TO AIRWAY REACTIVITY. CLIN SCI. 65:P54-P54.
  • SNASHALL PD; MORGAN BM; CHUNG KF. (1983). INFLUENCE OF BASELINE AIRWAY CALIBER ON HUMAN BRONCHIAL DOSE-RESPONSE CURVES. B EUR PHYSIOPATH RES. 19:P9-P9.
  • CHUNG KF; KEYES SJ; MORGAN BM; JONES PW; SNASHALL PD. (1983). MECHANISMS OF AIRWAY NARROWING IN ACUTE PULMONARY-EDEMA IN DOGS - INFLUENCE OF THE VAGUS AND LUNG-VOLUME. CLIN SCI. 65:289-296.
  • CHUNG KF; SNASHALL PD. (1983). SUPPRESSION OF PROLONGED FEVER DURING TREATMENT OF PULMONARY TUBERCULOSIS - IMPORTANCE OF USING TWICE VERSUS SINGLE DAILY DOSE OF PREDNISOLONE. POSTGRAD MED J. 59:373-375.
  • STEVENSON DJ; CHUNG KF; SNASHALL PD. (1983). THE EFFECT UPON SPECIFIC AIRWAY CONDUCTANCE AND BRONCHIAL REACTIVITY OF BRONCHODILATATION WITH SALBUTAMOL. CLIN SCI. 65:P38-P38.
  • JONES PW; KEYES SJ; MORGAN BM; CHUNG KF; SNASHALL PD. (1982). ACTIVE CONTROL OF FUNCTIONAL RESIDUAL CAPACITY IN ANESTHETIZED DOGS. CLIN SCI. 63:P40-P41.
  • CHUNG KF; MORGAN B; KEYES SJ; SNASHALL PD. (1982). HISTAMINE DOSE-RESPONSE RELATIONSHIPS IN NORMAL AND ASTHMATIC SUBJECTS - THE IMPORTANCE OF STARTING AIRWAY CALIBER. AM REV RESPIR DIS. 126:849-854.
  • CHUNG KF. (1982). LARYNGEAL STRIDOR DURING ACUTE ASTHMA. LANCET. 2:767-767.
  • SNASHALL PD; KEYES SJ; MORGAN BM; CHUNG KF. (1982). PULMONARY INTERSTITIAL COMPLIANCE - A FUNCTION OF THE OSMOTIC CONSTITUENTS OF THE INTERSTITIUM. J APPL PHYSIOL. 53:324-329.
  • CHUNG KF; MORGAN BM; SNASHALL PD. (1982). THE EFFECT OF PRIOR BRONCHOCONSTRICTION ON THE BRONCHIAL RESPONSE TO INHALED HISTAMINE. CLIN SCI. 63:P40-P40.
  • CHUNG KF; KEYES SJ; SNASHALL PD. (1981). DOSE-REPONSE CURVES INVIVO IN THE INVESTIGATION OF AGONIST-ANTAGONIST REACTIONS IN THE TRACHEO-BRONCHIAL TREE. CLIN SCI. 60:P31-P31.
  • CHUNG KF; MORGAN B; SNASHALL PD. (1981). EFFECTS OF PHARMACOLOGICAL ANTAGONISTS ON THE SLOPE AND POSITION OF HISTAMINE DOSE-RESPONSE CURVES - IMPORTANCE OF INITIAL BRONCHIAL CALIBER. CLIN SCI. 61:P6-P6.
  • SNASHALL PD; KEYES SJ; MORGAN B; JONES PW; CHUNG KF. (1981). MECHANISMS OF BRONCHIAL NARROWING IN PULMONARY-EDEMA. CLIN SCI. 61:P27-P27.
  • CHUNG KF. (1979). AMIODARONE AND THE THYROID. LANCET. 1:785-785.

Books

  • Chung KF; Bel EH; Wenzel SE. Chung KF (ed); Bel EH (ed); Wenzel SE (ed). Difficult-to-treat Severe Asthma. 1-308. European Respiratory Society (2011).
  • Chung KF. Adcock IM (ed); Chung KF (ed). Overcoming steroid insensitivity in respiratory disease. 1-292. Wiley (2008).
  • Chung K. Chung KF (ed). Airway smooth muscle in asthma and COPD: biology and pharmacology. First:1-312. Wiley, UK (2008).
  • Chung KF, Widdicombe JG, Boushey HA. Cough: mechanisms, causes and therapy. first:1-304. Blackwell Publishing, Bath (2003).
  • Chung KF; Widdicombe JG; Boushey H. Cough: mechanisms, causes and therapy. 1-304. Blackwell Science, CPI Bath (2003).

Chapters in books

  • Chung KF; Widdicombe JG. Cough. In Murray and Nadel's textbook of Respiratory Medicine. Second:831-847. Mason RJ (ed); Broaddus VC (ed); Murray JF (ed); Nadel JA (ed). Elsevier Saunders (2005).
  • Sukkar M; Chung KF. Expression and function of toll-like receptors in smooth muscle cells. In New frontiers in smooth muscle biology and physiology. 411-430. Savineau JP (ed). (2007).
  • Chung KF. Lipid mediators: platelet activating factor. In Encyclopaedia of Respiratory Medicine. 589-594. Laurent JG (ed); Shapiro SD (ed). Elsevier Ltd (2006).

Conferences

  • Chung KF. Neurogenic mechanisms in asthma. 129-136. (1997).
  • Chung KF. Nitric oxide in asthma. 53-60. (1997).
  • Chung KF. Currently available cough suppressants for chronic cough. 1st American Cough Conference. 186:S82-S87. (Jan 2008).
  • Macedo P; Campbell D; Durham SR; Chung KF; Menzies-Gow A. Prednisolone pharmacokinetics in severe asthmatics: Delayed absorption and failure to suppress endogenous cortisol. Winter Meeting of the British-Thoracic-Society. 62:A96-A97. (Dec 2007).
  • Niveni R; Pavord I; Laviolette M; Thomson N; Corris P; Cox G; Fan-Chung K; Sperb-Rubin A. Bronchial thermoplasty in refractory asthma: Interim results in a severe asthma population (Research in severe asthma (RISA) trial) - Abstracts. Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology. 119:S1-S1. (Jan 2007).
  • Chung KF. How can we resolve cortico-resistant and cortico-dependent asthma?. 12th Parisian Meeting of Allergy. 45:17-24. (Jan 2005).
  • McCreanor JE; Stewart-Evans J; Zhang J; Nieuwenhuijsen MJ; Svartengren M; Ohman-Strickland P; Jarup L; Chung KF; et alCullinan P. Deleterious effect of diesel fine particulate exposure in Oxford Street on asthma. 60:II5-II5. (1 Dec 2005).
  • Chung KF. Cytokines in chronic obstructive pulmonary disease. 18:50S-59S. (Dec 2001). DOI.
  • CHUNG KF; BARNES PJ. ROLE FOR PLATELET-ACTIVATING-FACTOR IN ASTHMA. 26:1277-1279. (Dec 1991).

Patents

  • treatment of corticoid-resistant asthma or COPD with p38 MAP kinase inhibit. Patent number: WO/2008/087437. Application: PCT/GB2008/000183. Filed: 18 Jan 2008. Published: 24 Jul 2008.
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