Dr Gabriela Da Silva Xavier

Publications


Journals

  • Locke JM; Da Silva Xavier G; Rutter GA; Harries LW. (Dec 2011). Erratum to: An alternative polyadenylation signal in TCF7L2 generates isoforms that inhibit T cell factor/lymphoid-enhancer factor (TCF/LEF)-dependent target genes. Diabetologia. 54:3170. DOI.
  • Locke JM; Da Silva Xavier G; Rutter GA; Harries LW. (Dec 2011). An alternative polyadenylation signal in TCF7L2 generates isoforms that inhibit T cell factor/lymphoid-enhancer factor (TCF/LEF)-dependent target genes. Diabetologia. 54:3078-3082. DOI.
  • Pullen TJ; Xavier GDS; Kelsey G; Rutter GA. (1 Aug 2011). miR-29a and miR-29b Contribute to Pancreatic beta-Cell-Specific Silencing of Monocarboxylate Transporter 1 (Mct1). MOLECULAR AND CELLULAR BIOLOGY. 31:3182-3194. DOI.
  • Meur G; Qian Q; da Silva Xavier G; Pullen TJ; Tsuboi T; McKinnon C; Fletcher L; Tavaré JM; et alHughes S; Johnson P; Rutter GA. (15 Apr 2011). Nucleo-cytosolic shuttling of FoxO1 directly regulates mouse Ins2 but not Ins1 gene expression in pancreatic beta cells (MIN6). J Biol Chem. 286:13647-13656. DOI.
  • da Silva Xavier G; Farhan H; Kim H; Caxaria S; Johnson P; Hughes S; Bugliani M; Marselli L; et alMarchetti P; Birzele F; Sun G; Scharfmann R; Rutter J; Siniakowicz K; Weir G; Parker H; Reimann F; Gribble FM; Rutter GA. (Apr 2011). Per-arnt-sim (PAS) domain-containing protein kinase is downregulated in human islets in type 2 diabetes and regulates glucagon secretion. Diabetologia. 54:819-827. DOI.
  • Dominguez V; Raimondi C; Somanath S; Bugliani M; Loder MK; Edling CE; Divecha N; da Silva-Xavier G; et alMarselli L; Persaud SJ; Turner MD; Rutter GA; Marchetti P; Falasca M; Maffucci T. (11 Feb 2011). Class II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic beta cells. J Biol Chem. 286:4216-4225. DOI.
  • da Silva Xavier G; Sun G; Qian Q; Rutter GA; Leclerc I. (12 Nov 2010). ChREBP regulates Pdx-1 and other glucose-sensitive genes in pancreatic β-cells. Biochem Biophys Res Commun. 402:252-257. DOI.
  • An R; da Silva Xavier G; Semplici F; Vakhshouri S; Hao HX; Rutter J; Pagano MA; Meggio F; et alPinna LA; Rutter GA. (20 Aug 2010). Pancreatic and duodenal homeobox 1 (PDX1) phosphorylation at serine-269 is HIPK2-dependent and affects PDX1 subnuclear localization. Biochem Biophys Res Commun. 399:155-161. DOI.
  • Sun G; Tarasov AI; McGinty J; McDonald A; da Silva Xavier G; Gorman T; Marley A; French PM; et alParker H; Gribble F; Reimann F; Prendiville O; Carzaniga R; Viollet B; Leclerc I; Rutter GA. (May 2010). Ablation of AMP-activated protein kinase alpha1 and alpha2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo. Diabetologia. 53:924-936. DOI.
  • Voronina SG; Barrow SL; Simpson AW; Gerasimenko OV; da Silva Xavier G; Rutter GA; Petersen OH; Tepikin AV. (May 2010). Dynamic changes in cytosolic and mitochondrial ATP levels in pancreatic acinar cells. Gastroenterology. 138:1976-1987. DOI.
  • Noordeen NA; Khera TK; Sun G; Longbottom ER; Pullen TJ; da Silva Xavier G; Rutter GA; Leclerc I. (Jan 2010). Carbohydrate-responsive element-binding protein (ChREBP) is a negative regulator of ARNT/HIF-1beta gene expression in pancreatic islet beta-cells. Diabetes. 59:153-160. DOI.
  • Nicolson TJ; Bellomo EA; Wijesekara N; Loder MK; Baldwin JM; Gyulkhandanyan AV; Koshkin V; Tarasov AI; et alCarzaniga R; Kronenberger K; Taneja TK; da Silva Xavier G; Libert S; Froguel P; Scharfmann R; Stetsyuk V; Ravassard P; Parker H; Gribble FM; Reimann F; Sladek R; Hughes SJ; Johnson PR; Masseboeuf M; Burcelin R; Baldwin SA; Liu M; Lara-Lemus R; Arvan P; Schuit FC; Wheeler MB; Chimienti F; Rutter GA. (Sep 2009). Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants. Diabetes. 58:2070-2083. DOI.
  • da Silva Xavier G; Loder MK; McDonald A; Tarasov AI; Carzaniga R; Kronenberger K; Barg S; Rutter GA. (Apr 2009). TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells. Diabetes. 58:894-905. DOI.
  • Loder MK; da Silva Xavier G; McDonald A; Rutter GA. (Jun 2008). TCF7L2 controls insulin gene expression and insulin secretion in mature pancreatic beta-cells. Biochem Soc Trans. 36:357-359. DOI.
  • Barrow SL; Voronina SG; da Silva Xavier G; Chvanov MA; Longbottom RE; Gerasimenko OV; Petersen OH; Rutter GA; et alTepikin AV. (Mar 2008). ATP depletion inhibits Ca2+ release, influx and extrusion in pancreatic acinar cells but not pathological Ca2+ responses induced by bile. Pflugers Arch. 455:1025-1039. DOI.
  • Zatyka M; Ricketts C; da Silva Xavier G; Minton J; Fenton S; Hofmann-Thiel S; Rutter GA; Barrett TG. (15 Jan 2008). Sodium-potassium ATPase 1 subunit is a molecular partner of Wolframin, an endoplasmic reticulum protein involved in ER stress. Hum Mol Genet. 17:190-200. DOI.
  • Guillemain G; Filhoulaud G; Da Silva-Xavier G; Rutter GA; Scharfmann R. (18 May 2007). Glucose is necessary for embryonic pancreatic endocrine cell differentiation. J Biol Chem. 282:15228-15237. DOI.
  • An R; Da Silva Xavier G; Hao H-X; Semplici F; Rutter J; Rutter GA. (1 Mar 2007). Phosphorylation by Per-Arnt-Sim (PAS) kinase may lead to nuclear exclusion and transcriptional repression of pancreatic duodenum homeobox-1 (PDX-1). DIABETIC MEDICINE. 24:2-2. Author weblink.
  • Rencurel F; Foretz M; Kaufmann MR; Stroka D; Looser R; Leclerc I; da Silva Xavier G; Rutter GA; et alViollet B; Meyer UA. (Dec 2006). Stimulation of AMP-activated protein kinase is essential for the induction of drug metabolizing enzymes by phenobarbital in human and mouse liver. Mol Pharmacol. 70:1925-1934. DOI.
  • da Silva Xavier G; Rutter GA; Diraison F; Andreolas C; Leclerc I. (Nov 2006). ChREBP binding to fatty acid synthase and L-type pyruvate kinase genes is stimulated by glucose in pancreatic beta-cells. J Lipid Res. 47:2482-2491. DOI.
  • An R; da Silva Xavier G; Hao HX; Semplici F; Rutter J; Rutter GA. (Nov 2006). Regulation by Per-Arnt-Sim (PAS) kinase of pancreatic duodenal homeobox-1 nuclear import in pancreatic beta-cells. Biochem Soc Trans. 34:791-793. DOI.
  • Reimann F; Williams L; da Silva Xavier G; Rutter GA; Gribble FM. (Sep 2004). Glutamine potently stimulates glucagon-like peptide-1 secretion from GLUTag cells. Diabetologia. 47:1592-1601. DOI.
  • Rutter GA; Leclerc I; Tsuboi T; da Silva Xavier G; Diraison F; Qian Q. (Jul 2004). Imaging Glucose-Regulated Insulin Secretion and Gene Expression in Single Islet β-Cells: Control by AMP-Activated Protein Kinase. Cellular biochem and biophys review. 3s, 40:179-190.
  • da Silva Xavier G; Rutter J; Rutter GA. (1 Jun 2004). Involvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucose. Proc Natl Acad Sci U S A. 101:8319-8324. DOI.
  • Leclerc I; Woltersdorf WW; da Silva Xavier G; Rowe RL; Cross SE; Korbutt GS; Rajotte RV; Smith R; et alRutter GA. (Jun 2004). Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion. Am J Physiol Endocrinol Metab. 286:E1023-E1031. DOI.
  • Guillemain G; Da Silva Xavier G; Rafiq I; Leturque A; Rutter GA. (15 Feb 2004). Importin beta1 mediates the glucose-stimulated nuclear import of pancreatic and duodenal homeobox-1 in pancreatic islet beta-cells (MIN6). Biochem J. 378:219-227. DOI.
  • Da Silva Xavier G; Qian Q; Cullen PJ; Rutter GA. (1 Jan 2004). Distinct roles for insulin and insulin-like growth factor-1 receptors in pancreatic beta-cell glucose sensing revealed by RNA silencing. Biochem J. 377:149-158. DOI.
  • Tsuboi T; da Silva Xavier G; Leclerc I; Rutter GA. (26 Dec 2003). 5'-AMP-activated protein kinase controls insulin-containing secretory vesicle dynamics. J Biol Chem. 278:52042-52051. DOI.
  • Rutter GA; Da Silva Xavier G; Leclerc I. (1 Oct 2003). Roles of 5'-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis. Biochem J. 375:1-16. DOI.
  • da Silva Xavier G; Leclerc I; Varadi A; Tsuboi T; Moule SK; Rutter GA. (1 May 2003). Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression. Biochem J. 371:761-774. DOI.
  • Tsuboi T; da Silva Xavier G; Holz GG; Jouaville LS; Thomas AP; Rutter GA. (15 Jan 2003). Glucagon-like peptide-1 mobilizes intracellular Ca2+ and stimulates mitochondrial ATP synthesis in pancreatic MIN6 beta-cells. Biochem J. 369:287-299. DOI.
  • Andreolas C; da Silva Xavier G; Diraison F; Zhao C; Varadi A; Lopez-Casillas F; Ferré P; Foufelle F; et alRutter GA. (Aug 2002). Stimulation of acetyl-CoA carboxylase gene expression by glucose requires insulin release and sterol regulatory element binding protein 1c in pancreatic MIN6 beta-cells. Diabetes. 51:2536-2545.
  • Leclerc I; Viollet B; da Silva Xavier G; Kahn A; Rutter GA. (Apr 2002). Role of AMP-activated protein kinase in the regulation of gene transcription. Biochem Soc Trans. 30:307-311.
  • Leclerc I; da Silva Xavier G; Rutter GA. (2002). AMP- and stress-activated protein kinases: key regulators of glucose-dependent gene transcription in mammalian cells?. Prog Nucleic Acid Res Mol Biol. 71:69-90.
  • da Silva Xavier G; Varadi A; Ainscow EK; Rutter GA. (17 Nov 2000). Regulation of gene expression by glucose in pancreatic beta -cells (MIN6) via insulin secretion and activation of phosphatidylinositol 3'-kinase. J Biol Chem. 275:36269-36277. DOI.
  • Rafiq I; da Silva Xavier G; Hooper S; Rutter GA. (26 May 2000). Glucose-stimulated preproinsulin gene expression and nuclear trans-location of pancreatic duodenum homeobox-1 require activation of phosphatidylinositol 3-kinase but not p38 MAPK/SAPK2. J Biol Chem. 275:15977-15984.
  • da Silva Xavier G; Leclerc I; Salt IP; Doiron B; Hardie DG; Kahn A; Rutter GA. (11 Apr 2000). Role of AMP-activated protein kinase in the regulation by glucose of islet beta cell gene expression. Proc Natl Acad Sci U S A. 97:4023-4028.

Chapters in books

  • Rutter GA; da Silva Xavier G; Tsuboi T; Mitchell K; Hanrahan JW. ). Probing cellular function with bioluminescence imaging. In Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. Wiley J (ed); Sons (ed). John Wiley and Sons (2003).

Conferences

  • Rutter GA; Pullen TJ. miR-29a, miR-29b and miR-124 contribute to pancreatic beta cell specific silencing of monocarboxylate transporter 1 (Mct1/Slc16a1). 46th Annual Meeting of the European-Association-for-the- Study-of-Diabetes (EASD), 20 Sep 2010 - 24 Sep 2010. 53:S35-S36. SPRINGER (1 Sep 2010).
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