All Publications

Journals

• Svensson CI; Inoue T; Hammaker D; Fukushima A; Papa S; Franzoso G; Schett G; Corr M; et al. (Nov 2009). Gadd45 beta Deficiency in Rheumatoid Arthritis Enhanced Synovitis Through JNK Signaling. ARTHRITIS RHEUM. 60:3229-3240. DOI.
• Mauro C; Zazzeroni F; Papa S; Bubici C; Franzoso G. (2009). The NF-kappaB transcription factor pathway as a therapeutic target in cancer: methods for detection of NF-kappaB activity. Methods Mol Biol. 512:169-207. DOI.
• Liu B; Suyeoka G; Papa S; Franzoso G; Neufeld AH. (Jan 2009). Growth arrest and DNA damage protein 45b (Gadd45b) protects retinal ganglion cells from injuries. NEUROBIOL DIS. 33:104-110. DOI.
• Papa S; Zazzeroni F; Fu YX; Bubici C; Alvarez K; Dean K; Christiansen PA; Anders RA; et al. (May 2008). Gadd45beta promotes hepatocyte survival during liver regeneration in mice by modulating JNK signaling. J Clin Invest. 118:1911-1923. DOI.
• Tornatore L; Marasco D; Dathan N; Vitale RM; Benedetti E; Papa S; Franzoso G; Ruvo M; et al. (18 Apr 2008). Gadd45 beta forms a homodimeric complex that binds tightly to MKK7. J MOL BIOL. 378:97-111. DOI.
• Kuntzen C; Zazzeroni F; Pham CG; Papa S; Bubici C; Knabb JR; Franzoso G. (2007). A method for isolating prosurvival targets of NF-kappaB/Rel transcription factors. Methods Mol Biol. 399:99-124.
• Pham CG; Bubici C; Zazzeroni F; Knabb JR; Papa S; Kuntzen C; Franzoso G. (Jun 2007). Upregulation of Twist-1 by NF-kappaB blocks cytotoxicity induced by chemotherapeutic drugs. Mol Cell Biol. 27:3920-3935. DOI.
• Papa S; Monti SM; Vitale RM; Bubici C; Jayawardena J; Alvarez K; De Smaele E; Dathan N; et al. (2007). Insights into the structural basis of the Gadd45β-mediated inactivation of the JNK kinase, MKK7/JNKK2. J. Biol. Chem. 282:19029-19041.
• Centeno C; Repici M; Chatton J; Riederer BM; Bonny C; Nicod P; Price M; Clarke PGH; et al. (2007). Protective features of a cell-permeable JNK inhibitor peptide against excitotoxicity: identification of a new key modulator of a death signalling pathway in cortical neurons. Cell Death Diff. 14:240-253.
• Bubici C; Papa S; Dean K; Franzoso G. (30 Oct 2006). Mutual cross-talk between reactive oxygen species and nuclear factor-kappa B: molecular basis and biological significance. Oncogene. 25:6731-6748. DOI.
• Papa S; Bubici C; Zazzeroni F; Pham CG; Kuntzen C; Knabb JR; Dean K; Franzoso G. (May 2006). The NF-kappaB-mediated control of the JNK cascade in the antagonism of programmed cell death in health and disease. Cell Death Differ. 13:712-729. DOI.
• Lo JC; Basak S; James ES; Quiambo R; Kinsella MC; Alegre ML; Weih F; Franzoso G; et al. (2006). Coordination between NF-κB family members p50 and p52 is essential for mediating LTβR signals in the development and orgnization of secondary lymphoid tissues. Blood. 107:1048-1055.
• Larsen CM; Døssing MG; Papa S; Franzoso G; Billestrup N; Mandrup-Poulsen T. (2006). Growth arrest- and DNA-damage-inducible gene 45β inhibits c-jun N-terminal kinase and extracellular signal regulated kinase and decreases IL-1β-induced apoptosis in insulin-producing INS-1E cells. Diabetologia. 49:712-729.
• Mittal A; Papa A; Franzoso G; Sen R. (2006). NF-κB-dependent regulation of the timing of activation induced cell death of T lymphocytes. J. Immunol. 176:2183-2189.
• Bubici C; Papa S; Pham CG; Zazzeroni F; Franzoso G. (Jan 2006). The NF-kappaB-mediated control of ROS and JNK signaling. Histol Histopathol. 21:69-80.
• Yang H; Bocchetta M; Kroczynska B; Elmishad AG; Liu Z; Bubici C; Mossman BT; Pass HI; et al. (2006). TNFα inhibits asbestos induced cytotoxicity via a NF-κB-dependent pathway: a possible mechanism for asbestos induced oncogenesis. Proc. Natl. Acad. Sci. (U.S.A.). 103:10397-10402.
• Pham CG; Papa S; Bubici C; Zazzeroni F; Franzoso G. (Apr 2005). Oxygen JNKies: phosphatases overdose on ROS. Dev Cell. 8:452-454. DOI.
• Pham CG; Papa S; Bubici C; Zazzeroni F; Franzoso G. (2005). In the crosshairs: NF-κB targets the JNK signaling cascade. Curr. Med. Chem. - AIAA. 4:569-576.
• Papa S; Bubici C; Pham CG; Zazzeroni F; Franzoso G. (2005). NF-κB meets ROS: an “iron-ic” encounter. Cell Death Diff. 12:1259-1262.
• Pham CG; Bubici C; Zazzeroni F; Papa S; Jones J; Alvarez K; Jayawardena S; De Smaele E; et al. (12 Nov 2004). Ferritin heavy chain upregulation by NF-kappaB inhibits TNFalpha-induced apoptosis by suppressing reactive oxygen species. Cell. 119:529-542. DOI.
• Papa S; Zazzeroni F; Pham CG; Bubici C; Franzoso G. (15 Oct 2004). Linking JNK signaling to NF-kappaB: a key to survival. J Cell Sci. 117:5197-5208. DOI.
• Barnhart BC; Legembre P; Pietras E; Bubici C; Franzoso G; Peter ME. (4 Aug 2004). CD95 ligand induces motility and invasiveness of apoptosis-resistant tumor cells. EMBO J. 23:3175-3185. DOI.
• Papa S; Zazzeroni F; Bubici C; Jayawardena S; Alvarez K; Matsuda S; Nguyen DU; Pham CG; et al. (Feb 2004). Gadd45 beta mediates the NF-kappa B suppression of JNK signalling by targeting MKK7/JNKK2. Nat Cell Biol. 6:146-153. DOI.
• Bubici C; Papa S; Pham CG; Zazzeroni F; Franzoso G. (2004). NF-κB and JNK: an intricate affair. Cell Cycle. 359:1524-1529.
• Zazzeroni F; Papa S; Algeciras-Schimnich A; Alvarez K; Melis T; Bubici C; Majewski N; Hay N; et al. (1 Nov 2003). Gadd45 beta mediates the protective effects of CD40 costimulation against Fas-induced apoptosis. Blood. 102:3270-3279. DOI.
• Liu N; Raja SM; Zazzeroni F; Metkar SS; Shah R; Zhang M; Wang Y; Brömme D; et al. (1 Oct 2003). NF-kappaB protects from the lysosomal pathway of cell death. EMBO J. 22:5313-5322. DOI.
• Zazzeroni F; Papa S; De Smaele E; Franzoso G. (2003). Cell survival and Gadd45-factor deficiency. Nature. 424:742.
• Lo JC; Chin RK; Lee Y; Kang H; Wang Y; Weinstock JV; Banks T; Ware CF; et al. (2003). Differential regulation of CCL21 in lymphoid/nonlymphoid tissues for effectively attracting T cells to peripheral tissues. J. Clin. Invest. 112:1495-1504.
• Franzoso G; Zazzeroni F; Papa S. (2003). JNK: a killer on a transcriptional leash. Cell Death Differ. 10:13-15.
• Medici MA; Sciortino MT; Perri D; Amici C; Avitable E; Ciotti M; Balestrieri E; De Smaele E; et al. (2003). Protection by herpes simplex virus glycoprotein D against Fas-mediated apoptosis: Role of nuclear factor-κB. J. Biol. Chem. 278:36059-36067.
• Jin R; De Smaele E; Zazzeroni F; Nguyen DU; Papa S; Jones J; Cox C; Gelinas C; et al. (Jul 2002). Regulation of the gadd45beta promoter by NF-kappaB. DNA Cell Biol. 21:491-503. DOI.
• Guiet C; Silvestri E; DeSmaele E; Franzoso G; Vito P. (2002). c-FLIP efficiently rescues TRAF2-/- cells from TNF-induced apoptosis. Cell Death Differ. 91:138-144.
• De Smaele E; Zazzeroni F; Papa S; Nguyen DU; Jin R; Jones J; Cong R; Franzoso G. (15 Nov 2001). Induction of gadd45beta by NF-kappaB downregulates pro-apoptotic JNK signalling. Nature. 414:308-313. DOI.
• Leonardi A; Ellinger-Ziegelbauer H; Franzoso G; Brown G; Siebenlist U. (2000). Physical and functional interaction of filamin (actin-binding protein-280) and tumor necrosis factor receptor-associated factor 2. J. Biol. Chem. 275:271-278.
• St.Louis DC; Woodstock J; Franzoso G; Blair PJ; Carlson LM; Murillo M; Wells MR; Williams AJ; et al. (1999). Evidence for distinct intracellular signaling pathways in CD34+ progenitor to dendritic cell differentiation from a human cell line model. J. Immunol. 162:3237-3248.
• Chariot A; Princen F; Gielen J; Merville MP; Franzoso G; Brown K; Siebenlist U; Bours V. (1999). IκB-α enhances transactivation by the HOXB7 homeodomain-containing protein. J. Biol. Chem. 274:5318-5325.
• Boyce BF; Xing L; Franzoso G; Siebenlist U. (1999). Required and nonessential functions of nuclear factor-κB in bone cells. Bone. 25:137-139.
• Franzoso G; Carlson L; Poljak L; Shores EW; Epstein S; Leonardi A; Grinberg A; Tran T; et al. (1998). Mice Deficient in NF-κB/p52 present with defects in humoral responses, germinal center reactions and splenic microarchitecture. J. Exp. Med. 187:147-159.
• Franzoso G; Carlson L; Sharton-Kersten T; Shores EW; Epstein S; Grinberg A; Tran T; Shacter E; et al. (1997). Critical roles for the Bcl-3 oncoprotein in T cell-mediated immunity, splenic microarchitecture and germinal center reactions. Immunity. 6:479-490.
• Franzoso G; Carlson L; Xing L; Poljak L; Shores EW; Brown KD; Leonardi A; Tran T; et al. (1997). Requirement for NF-κB in osteoclast and B cell development. Genes Dev. 11:3482-3496.
• Brown KD; Franzoso G; Baldi L; Carlson L; Mills L; Lin Y; Gerstberger S; Siebenlist U. (1997). The signal response of IκB-α is regulated by transferable N- and C-terminal domains. Mol. Cell. Biol. 17:3021-3027.
• Franzoso G; Carlson L; Brown K; Daucher M; Bressler P; Siebenlist U. (1996). Activation of the Serum Response Factor (SRF) by p65/NF-κB. EMBO J. 15:3403-3412.
• Baldi L; Brown K; Franzoso G; Siebenlist U. (1996). Critical role for lysines 21 and 22 in signal-induced, ubiquitin-mediated proteolysis of IκB-α. J. Biol. Chem. 271:376-379.
• Ruocco MR; Chen X; Ambrosino C; Dragonetti E; Liu W; Mallardo M; De Falco G; Palmieri C; et al. (1996). Regulation of HIV-1 Long Terminal Repeats by interaction of C/EBP (NF-IL6) and NF-κB/Rel transcription factors. J. Biol. Chem. 271:22479-22486.
• Brown K; Gerstberger S; Carlson L; Franzoso G; Siebenlist U. (1995). Control of IκB-α proteolysis by site-specific signal-induced phosphorylation. Science. 267:1485-1488.
• Drew PD; Franzoso G; Becker KG; Bours V; Carlson LC; Siebenlist U; Ozato K. (1995). Interferon Regulatory Factor-2 physically interacts with NF-κB and inhibits NF-κB induction of Major Histocompatibility Class I and β2-microglobulin gene expression in transfected human neuronal cells. J. Neuroimmunol. 63:157-162.
• Drew PD; Franzoso G; Becker KG; Bours V; Carlson LC; Siebenlist U; Ozato K. (1995). NF-κB and Interferon Regulatory Factor-1 physically interact and synergistically induce Major Histocompatibility Class I gene expression. J. Interf. Cytok. Res. 15:1037-1045.
• Franzoso G; Biswas P; Poli G; Carlson L; Brown K; Tomita-Yamaguchi M; Fauci AS; Siebenlist U. (1994). A family of serine proteases expressed exclusively in myelo-monocytic cells specifically processes the Nuclear Factor-κB subunit p65 in vitro and may impair Human Immunodeficiency Virus replication in these cells. J. Exp. Med. 180:1445-1456.
• Kanno T; Franzoso G; Siebenlist U. (1994). Human T cell leukemia virus type Tax-protein-mediated activation of NF-κB from p100 (NF-κB2)-inhibited cytoplasmic reservoirs. Proc. Natl. Acad. Sci. (U.S.A.). 91:12634-12638.
• Franzoso G; Hu P; Meloni GA; Barile MF. (1994). Immunoblot analyses of chimpanzee sera after infection and after immunization and challenge with Mycoplasma pneumoniae. Infect. Immun. 62:1008-1014.
• Kanno T; Brown K; Franzoso G; Siebenlist U. (1994). Kinetic analysis of Human T-cell Leukemia Virus type I Tax-mediated activation of NF-κB. Mol. Cell. Biol. 14:6443-6451.
• Siebenlist U; Brown G; Franzoso G. (1994). NF-κB: a mediator of pathogen and stress responses. Inducible Gene Expression. 93-141.
• Siebenlist U; Franzoso G; Brown K. (1994). Structure, regulation and function of NF-κB. Annu. Rev. Cell Biol. 10:405-455.
• Brown K; Park S; Kanno T; Franzoso G; Siebenlist U. (1993). Mutual regulation of the transcriptional activator NF-κB and its inhibitor, IκB-α. Proc. Natl. Acad. Sci. (U.S.A.). 90:2532-2536.
• Dimitrov DS; Franzoso G; Salman M; Blumenthal R; Tarshis M; Barile MF; Rottem S. (1993). Mycoplasma fermentans (incognitus strain) cells are able to fuse with T-lymphocytes. Clin. Infect. Dis. 17:S305-S308.
• Segars JH; Nagata T; Bours V; Medin JA; Franzoso G; Blanco JCG; Drew PD; Becker KG; et al. (1993). Retinoic acid induction of Major Histocompatibility Complex class I genes in NTera-2 embryonal carcinoma cells involves induction of NF-κB (p50/p65) and Retinoic Acid Receptor β-Retinoid X Receptor β heterodimers. Mol. Cell. Biol. 13:6157-6169.
• Franzoso G; Hu P; Meloni GA; Barile MF. (1993). The immunodominant 90 kilodalton protein is localized on the terminal tip structure of Mycoplasma pneumoniae. Infect. Immun. 61:1523-1530.
• Franzoso G; Bours V; Azarenko V; Park S; Tomita-Yamaguchi M; Kanno T; Brown K; Siebenlist U. (1993). The oncoprotein Bcl-3 can facilitate NF-κB- mediated transactivation by removing inhibiting p50 homodimers from select κB sites. EMBO J. 12:3893-3901.
• Bours V; Franzoso G; Azarenko V; Park S; Kanno T; Brown K; Siebenlist U. (1993). The oncoprotein Bcl-3 directly transactivates through κB motifs via association with DNA-binding p50B homodimers. Cell. 72:729-739.
• Franzoso G; Dimitrov DS; Blumenthal R; Barile MF; Rottem S. (1992). Fusion of Mycoplasma fermentans, strain incognitus, with T-lymphocytes. F.E.B.S. Letters. 303:251-254.
• Bours V; Franzoso G; Brown K; Park S; Azarenko V; Tomita-Yamaguchi M; Kelly K; Siebenlist U. (1992). Lymphocyte activation and the family of NF-κB transcription factor complexes. Curr. Top. Microbiol. Immunol. 182:411-420.
• Franzoso G; Bours V; Park S; Tomita-Yamaguchi M; Kelly K; Siebenlist U. (1992). The candidate oncoprotein Bcl-3 is an antagonist of p50/NF-κB-mediated inhibition. Nature. 359:339-342.
• Franzoso G; Cusinato R; Tonin EA; Meloni GA. (1991). Attivita` della claritromicina nei confronti di micoplasmi e clamidie. G. Ital. Chemioter. 38:159-161.
• Burra P; Franzoso G; Salvagnini M; Dalri L; Naccarato R. (1988). Comportamento della malondialdeide (MDA) quale indice di perossidazione lipidica e nella diagnosi delle epatopatie. Alcol e Benessere. 283-286.

Conferences

• Papa S; Bubici C; Zazzeroni F; Franzoso G. Mechanisms of liver disease: cross-talk between the NF-kappa B and JNK pathways. 4th International Conference of the Collaborative Research Center 575 Experimental Hepatology (SFB 575), 7 Nov 2008 - 8 Nov 2008. 390:965-976. WALTER DE GRUYTER & CO (Oct 2009). DOI.