Professor Guy A Rutter

Publications


Journals

  • Tarasov AI; Griffiths EJ; Rutter GA. (11 Apr 2012). Regulation of ATP production by mitochondrial Ca(2+). Cell Calcium. DOI.
  • Pullen TJ; Sylow L; Sun G; Halestrap AP; Richter EA; Rutter GA. (20 Apr 2012). Overexpression of Monocarboxylate Transporter-1 (Slc16a1) in Mouse Pancreatic β-Cells Leads to Relative Hyperinsulinism During Exercise. Diabetes. DOI.
  • Leclerc I; Rutter GA; Meur G; Noordeen N. (May 2012). Roles of Ca2+ ions in the control of ChREBP nuclear translocation. J Endocrinol. 213:115-122. DOI.
  • Noordeen NA; Meur G; Rutter GA; Leclerc I. (Mar 2012). Glucose-induced nuclear shuttling of ChREBP is mediated by sorcin and Ca(2+) ions in pancreatic β-cells. Diabetes. 61:574-585. DOI.
  • Li D; Chen S; Bellomo EA; Tarasov AI; Kaut C; Rutter GA; Li WH. (27 Dec 2011). Imaging dynamic insulin release using a fluorescent zinc indicator for monitoring induced exocytotic release (ZIMIR). Proc Natl Acad Sci U S A. 108:21063-21068. DOI.
  • Semplici F; Vaxillaire M; Fogarty S; Semache M; Bonnefond A; Fontés G; Philippe J; Meur G; et alDiraison F; Sessions RB; Rutter J; Poitout V; Froguel P; Rutter GA. (23 Dec 2011). Human mutation within Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) causes basal insulin hypersecretion. J Biol Chem. 286:44005-44014. DOI.
  • Locke JM; Da Silva Xavier G; Rutter GA; Harries LW. (Dec 2011). Erratum to: An alternative polyadenylation signal in TCF7L2 generates isoforms that inhibit T cell factor/lymphoid-enhancer factor (TCF/LEF)-dependent target genes. Diabetologia. 54:3170. DOI.
  • Locke JM; Da Silva Xavier G; Rutter GA; Harries LW. (Dec 2011). An alternative polyadenylation signal in TCF7L2 generates isoforms that inhibit T cell factor/lymphoid-enhancer factor (TCF/LEF)-dependent target genes. Diabetologia. 54:3078-3082. DOI.
  • Bellomo EA; Meur G; Rutter GA. (22 Jul 2011). Glucose Regulates Free Cytosolic Zn2+ Concentration, Slc39 (ZiP), and Metallothionein Gene Expression in Primary Pancreatic Islet beta-Cells. JOURNAL OF BIOLOGICAL CHEMISTRY. 286:25778-25789. DOI.
  • Pullen TJ; Xavier GDS; Kelsey G; Rutter GA. (1 Aug 2011). miR-29a and miR-29b Contribute to Pancreatic beta-Cell-Specific Silencing of Monocarboxylate Transporter 1 (Mct1). MOLECULAR AND CELLULAR BIOLOGY. 31:3182-3194. DOI.
  • Bellomo EA; Meur G; Rutter GA. (22 Jul 2011). Glucose regulates free cytosolic Zn²⁺ concentration, Slc39 (ZiP), and metallothionein gene expression in primary pancreatic islet β-cells. J Biol Chem. 286:25778-25789. DOI.
  • Meur G; Qian Q; da Silva Xavier G; Pullen TJ; Tsuboi T; McKinnon C; Fletcher L; Tavaré JM; et alHughes S; Johnson P; Rutter GA. (15 Apr 2011). Nucleo-cytosolic shuttling of FoxO1 directly regulates mouse Ins2 but not Ins1 gene expression in pancreatic beta cells (MIN6). J Biol Chem. 286:13647-13656. DOI.
  • da Silva Xavier G; Farhan H; Kim H; Caxaria S; Johnson P; Hughes S; Bugliani M; Marselli L; et alMarchetti P; Birzele F; Sun G; Scharfmann R; Rutter J; Siniakowicz K; Weir G; Parker H; Reimann F; Gribble FM; Rutter GA. (Apr 2011). Per-arnt-sim (PAS) domain-containing protein kinase is downregulated in human islets in type 2 diabetes and regulates glucagon secretion. Diabetologia. 54:819-827. DOI.
  • Sun G; Reynolds R; Leclerc I; Rutter GA. (Mar 2011). RIP2-mediated LKB1 deletion causes axon degeneration in the spinal cord and hind-limb paralysis. Dis Model Mech. 4:193-202. DOI.
  • Dominguez V; Raimondi C; Somanath S; Bugliani M; Loder MK; Edling CE; Divecha N; da Silva-Xavier G; et alMarselli L; Persaud SJ; Turner MD; Rutter GA; Marchetti P; Falasca M; Maffucci T. (11 Feb 2011). Class II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic beta cells. J Biol Chem. 286:4216-4225. DOI.
  • Pullen TJ; Khan AM; Barton G; Butcher SA; Sun G; Rutter GA. (Mar 2010). Identification of genes selectively disallowed in the pancreatic islet. Islets. 2:89-95. DOI.
  • Rutter GA. (Jan 2010). Think zinc: New roles for zinc in the control of insulin secretion. Islets. 2:49-50. DOI.
  • McDonald A; Fogarty S; Leclerc I; Hill EV; Hardie DG; Rutter GA. (Nov 2009). Control of insulin granule dynamics by AMPK dependent KLC1 phosphorylation. Islets. 1:198-209. DOI.
  • Yang CS; Lam CKL; Chari M; Cheung GWC; Kokorovic A; Gao S; Leclerc I; Rutter GA; et alLam TKT. (1 Oct 2010). Hypothalamic AMP-Activated Protein Kinase Regulates Glucose Production. DIABETES. 59:2435-2443. DOI.
  • Leclerc I; Sun G; Morris C; Fernandez-Millan E; Nyirenda M; Rutter GA. (Jan 2011). AMP-activated protein kinase regulates glucagon secretion from mouse pancreatic alpha cells. Diabetologia. 54:125-134. DOI.
  • da Silva Xavier G; Sun G; Qian Q; Rutter GA; Leclerc I. (12 Nov 2010). ChREBP regulates Pdx-1 and other glucose-sensitive genes in pancreatic β-cells. Biochem Biophys Res Commun. 402:252-257. DOI.
  • Lam CK; Chari M; Rutter GA; Lam TK. (Jan 2011). Hypothalamic nutrient sensing activates a forebrain-hindbrain neuronal circuit to regulate glucose production in vivo. Diabetes. 60:107-113. DOI.
  • Yang CS; Lam CK; Chari M; Cheung GW; Kokorovic A; Gao S; Leclerc I; Rutter GA; et alLam TK. (Oct 2010). Hypothalamic AMP-activated protein kinase regulates glucose production. Diabetes. 59:2435-2443. DOI.
  • An R; da Silva Xavier G; Semplici F; Vakhshouri S; Hao HX; Rutter J; Pagano MA; Meggio F; et alPinna LA; Rutter GA. (20 Aug 2010). Pancreatic and duodenal homeobox 1 (PDX1) phosphorylation at serine-269 is HIPK2-dependent and affects PDX1 subnuclear localization. Biochem Biophys Res Commun. 399:155-161. DOI.
  • Mbaya E; Oulès B; Caspersen C; Tacine R; Massinet H; Pennuto M; Chrétien D; Munnich A; et alRötig A; Rizzuto R; Rutter GA; Paterlini-Bréchot P; Chami M. (Dec 2010). Calcium signalling-dependent mitochondrial dysfunction and bioenergetics regulation in respiratory chain Complex II deficiency. Cell Death Differ. 17:1855-1866. DOI.
  • Wijesekara N; Dai FF; Hardy AB; Giglou PR; Bhattacharjee A; Koshkin V; Chimienti F; Gaisano HY; et alRutter GA; Wheeler MB. (Aug 2010). Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion. Diabetologia. 53:1656-1668. DOI.
  • Sun G; Tarasov AI; McGinty JA; French PM; McDonald A; Leclerc I; Rutter GA. (Jun 2010). LKB1 deletion with the RIP2.Cre transgene modifies pancreatic beta-cell morphology and enhances insulin secretion in vivo. Am J Physiol Endocrinol Metab. 298:E1261-E1273. DOI.
  • Sun G; Tarasov AI; McGinty J; McDonald A; da Silva Xavier G; Gorman T; Marley A; French PM; et alParker H; Gribble F; Reimann F; Prendiville O; Carzaniga R; Viollet B; Leclerc I; Rutter GA. (May 2010). Ablation of AMP-activated protein kinase alpha1 and alpha2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo. Diabetologia. 53:924-936. DOI.
  • Ravier MA; Rutter GA. (2010). Isolation and culture of mouse pancreatic islets for ex vivo imaging studies with trappable or recombinant fluorescent probes. Methods Mol Biol. 633:171-184. DOI.
  • Voronina SG; Barrow SL; Gerasimenko OV; Simpson AW; Rutter GA; Petersen OH; Tepikin AV. (1 Jan 2009). ATP CHANGES IN PANCREATIC ACINAR CELLS INDUCED BY STIMULATION WITH Ca2+-RELEASING SECRETAGOGUES AND ACTIVATORS OF ACUTE PANCREATITIS. JOURNAL OF PHYSIOLOGICAL SCIENCES. 59:242-242. Author weblink.
  • McDonald A; Fogarty S; Leclerc I; Hill EV; Hardie DG; Rutter GA. (Feb 2010). Cell-wide analysis of secretory granule dynamics in three dimensions in living pancreatic beta-cells: evidence against a role for AMPK-dependent phosphorylation of KLC1 at Ser517/Ser520 in glucose-stimulated insulin granule movement. Biochem Soc Trans. 38:205-208. DOI.
  • Voronina SG; Barrow SL; Simpson AW; Gerasimenko OV; da Silva Xavier G; Rutter GA; Petersen OH; Tepikin AV. (May 2010). Dynamic changes in cytosolic and mitochondrial ATP levels in pancreatic acinar cells. Gastroenterology. 138:1976-1987. DOI.
  • Meur G; Simon A; Harun N; Virally M; Dechaume A; Bonnefond A; Fetita S; Tarasov AI; et alGuillausseau PJ; Boesgaard TW; Pedersen O; Hansen T; Polak M; Gautier JF; Froguel P; Rutter GA; Vaxillaire M. (Mar 2010). Insulin gene mutations resulting in early-onset diabetes: marked differences in clinical presentation, metabolic status, and pathogenic effect through endoplasmic reticulum retention. Diabetes. 59:653-661. DOI.
  • Lerner RG; Depatie C; Rutter GA; Screaton RA; Balthasar N. (1 Oct 2009). A role for the CREB co-activator CRTC2 in the hypothalamic mechanisms linking glucose sensing with gene regulation. EMBO REPORTS. 10:1175-1181. DOI.
  • Vinkenborg JL; Nicolson TJ; Bellomo EA; Koay MS; Rutter GA; Merkx M. (1 Oct 2009). Genetically encoded FRET sensors to monitor intracellular Zn2+ homeostasis. NATURE METHODS. 6:737-U10. DOI.
  • Noordeen NA; Khera TK; Sun G; Longbottom ER; Pullen TJ; da Silva Xavier G; Rutter GA; Leclerc I. (Jan 2010). Carbohydrate-responsive element-binding protein (ChREBP) is a negative regulator of ARNT/HIF-1beta gene expression in pancreatic islet beta-cells. Diabetes. 59:153-160. DOI.
  • Griffiths EJ; Rutter GA. (1 Nov 2009). Mitochondrial calcium as a key regulator of mitochondrial ATP production in mammalian cells. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS. 1787:1324-1333. Author weblink DOI.
  • Nicolson TJ; Bellomo EA; Wijesekara N; Loder MK; Baldwin JM; Gyulkhandanyan AV; Koshkin V; Tarasov AI; et alCarzaniga R; Kronenberger K; Taneja TK; Xavier GDS; Libert S; Froguel P; Scharfmann R; Stetsyuk V; Ravassard P; Parker H; Gribble FM; Reimann F; Sladek R; Hughes SJ; Johnson PRV; Masseboeuf M; Burcelin R; Baldwin SA; Liu M; Lara-Lemus R; Arvan P; Schuit FC; Wheeler MB; Chimienti F; Rutter GA. (1 Sep 2009). Insulin Storage and Glucose Homeostasis in Mice Null for the Granule Zinc Transporter ZnT8 and Studies of the Type 2 Diabetes-Associated Variants. DIABETES. 58:2070-2083. Author weblink DOI.
  • Vinkenborg JL; Nicolson TJ; Bellomo EA; Koay MS; Rutter GA; Merkx M. (Oct 2009). Genetically encoded FRET sensors to monitor intracellular Zn2+ homeostasis. Nat Methods. 6:737-740. DOI.
  • Lemaire K; Ravier MA; Schraenen A; Creemers JW; Van de Plas R; Granvik M; Van Lommel L; Waelkens E; et alChimienti F; Rutter GA; Gilon P; in't Veld PA; Schuit FC. (1 Sep 2009). Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice. Proc Natl Acad Sci U S A. 106:14872-14877. DOI.
  • Rutter GA. (1 Feb 2009). Regulating Glucagon Secretion: Somatostatin in the Spotlight. DIABETES. 58:299-301. Author weblink DOI.
  • da Silva Xavier G; Loder MK; McDonald A; Tarasov AI; Carzaniga R; Kronenberger K; Barg S; Rutter GA. (Apr 2009). TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells. Diabetes. 58:894-905. DOI.
  • Ravier MA; Tsuboi T; Rutter GA. (Nov 2008). Imaging a target of Ca2+ signalling: dense core granule exocytosis viewed by total internal reflection fluorescence microscopy. Methods. 46:233-238. DOI.
  • Sun G; Xavier GDS; Riboulet-Chavey A; Taneja T; Leclerc I; Rutter GA. (1 Sep 2008). Over-expression of constitutively-activated or dominant-negative forms of AIMP-activated protein kinase (AMPK) selectively in the beta cells of transgenic mice exerts opposing effects on glucose tolerance. DIABETOLOGIA. 51:S202-S202. Author weblink.
  • Pullen TJ; Xavier GDS; Kelsey G; Rutter GA. (1 Sep 2008). Beta cell specific silencing of the plasma membrane monocarboxylate transporter MCT1 (SLC16A1) is not effected through methylation of its promoter. DIABETOLOGIA. 51:S195-S195. Author weblink.
  • Xavier GDS; McDonald RAA; Loder MK; Rutter GA. (1 Sep 2008). TCF7L2 regulates cell proliferation and differentiation in the developing pancreatic epithelium. DIABETOLOGIA. 51:S17-S17. Author weblink.
  • Rutter GA; Leclerc I. (15 Jan 2009). The AMP-regulated kinase family: enigmatic targets for diabetes therapy. Mol Cell Endocrinol. 297:41-49. DOI.
  • Loder MK; Xavier GDS; McDonald A; Rutter GA. (1 Jun 2008). TCF7L2 controls insulin gene expression and insulin secretion in mature pancreatic beta-cells. BIOCHEMICAL SOCIETY TRANSACTIONS. 36:357-359. Author weblink DOI.
  • Cunha DA; Hekerman P; Ladrière L; Bazarra-Castro A; Ortis F; Wakeham MC; Moore F; Rasschaert J; et alCardozo AK; Bellomo E; Overbergh L; Mathieu C; Lupi R; Hai T; Herchuelz A; Marchetti P; Rutter GA; Eizirik DL; Cnop M. (15 Jul 2008). Initiation and execution of lipotoxic ER stress in pancreatic beta-cells. J Cell Sci. 121:2308-2318. DOI.
  • Rutter GA; Wong FS. (Jun 2008). The pancreatic beta-cell: birth, life and death. Biochem Soc Trans. 36:267-271. DOI.
  • Diraison F; Ravier MA; Richards SK; Smith RM; Shimano H; Rutter GA. (1 Apr 2008). SREBP1 is required for the induction by glucose of pancreatic beta-cell genes involved in glucose sensing. JOURNAL OF LIPID RESEARCH. 49:814-822. Author weblink DOI.
  • Rutter GA; Bellomo EA. (1 Apr 2008). Ca2+ signalling: a new route to NAADP. Biochem J. 411:e1-e3. DOI.
  • Tarasov AI; Nicolson TJ; Riveline JP; Taneja TK; Baldwin SA; Baldwin JM; Charpentier G; Gautier JF; et alFroguel P; Vaxillaire M; Rutter GA. (Jun 2008). A rare mutation in ABCC8/SUR1 leading to altered ATP-sensitive K+ channel activity and beta-cell glucose sensing is associated with type 2 diabetes in adults. Diabetes. 57:1595-1604. DOI.
  • Riboulet-Chavey A; Diraison F; Siew LK; Wong FS; Rutter GA. (1 Feb 2008). Inhibition of AMP-activated protein kinase protects pancreatic beta-cells from cytokine-mediated apoptosis and CD8(+) T-cell-induced cytotoxicity. DIABETES. 57:415-423. Author weblink DOI.
  • Meissner T; Otonkoski T; Jiao H; Kaminen-Ahola N; Tapia-Paez I; Ullah MS; Parton LE; Schuit F; et alQuintens R; Sipilae I; Halestrap AP; Rutter GA; Kere J; Mayatepek E. (1 Mar 2008). Exercise-induced hyperinsulinism: A new disorder caused by promoter-activating mutations in the SLC16A1 gene. EUROPEAN JOURNAL OF PEDIATRICS. 167:365-365. Author weblink.
  • Zatyka M; Ricketts C; Xavier GDS; Minton J; Fenton S; Hofmann-Thiel S; Rutter GA; Barrett TG. (1 Jan 2008). Sodium-potassium ATPase beta 1 subunit is a molecular partner of Wolframin, an endoplasmic reticulum protein involved in ER stress. HUMAN MOLECULAR GENETICS. 17:190-200. Author weblink DOI.
  • Rutter GA; Parton LE. (2008). The beta-cell in type 2 diabetes and in obesity. Front Horm Res. 36:118-134. DOI.
  • Jacquet S; Zarrinpashneh E; Chavey A; Ginion A; Leclerc I; Viollet B; Rutter GA; Bertrand L; et alMarber MS. (1 Dec 2007). The relationship between p38 mitogen-activated protein kinase and AMP-activated protein kinase during myocardial ischemia. CARDIOVASCULAR RESEARCH. 76:465-472. Author weblink DOI.
  • Barrow SL; Voronina SG; da Silva Xavier G; Chvanov MA; Longbottom RE; Gerasimenko OV; Petersen OH; Rutter GA; et alTepikin AV. (Mar 2008). ATP depletion inhibits Ca2+ release, influx and extrusion in pancreatic acinar cells but not pathological Ca2+ responses induced by bile. Pflugers Arch. 455:1025-1039. DOI.
  • Rutter GA. (2007). Generating new candidate genes for neonatal diabetes: functional and genetic studies of insulin secretion in type 2 diabetes. Endocr Dev. 12:75-85. DOI.
  • Otonkoski T; Jiao H; Kaminen-Ahola N; Tapia-Paez I; Ullah MS; Parton LE; Schuit F; Quintens R; et alSipilä I; Mayatepek E; Meissner T; Halestrap AP; Rutter GA; Kere J. (Sep 2007). Physical exercise-induced hypoglycemia caused by failed silencing of monocarboxylate transporter 1 in pancreatic beta cells. Am J Hum Genet. 81:467-474. DOI.
  • Baroukh N; Ravier MA; Loder MK; Hill EV; Bounacer A; Scharfmann R; Rutter GA; Van Obberghen E. (6 Jul 2007). MicroRNA-124a regulates Foxa2 expression and intracellular signaling in pancreatic beta-cell lines. J Biol Chem. 282:19575-19588. DOI.
  • Bell CJ; Manfredi G; Griffiths EJ; Rutter GA. (2007). Luciferase expression for ATP imaging: application to cardiac myocytes. Methods Cell Biol. 80:341-352. DOI.
  • Ravier MA; Pellegatti P; Rutter GA. (1 Mar 2007). Simultaneous imaging of cytosolic and mitochondrial Ca2+ concentration during glucose-induced oscillations in single primary mouse beta-cells. DIABETIC MEDICINE. 24:11-11. Author weblink.
  • Riboulet-Chavey AC; Diraison FD; Rutter GA. (1 Mar 2007). Inhibition of AMP-activated protein kinase protects pancreatic beta-cells from cytokine-mediated apoptosis. DIABETIC MEDICINE. 24:2-2. Author weblink.
  • An R; Da Silva Xavier G; Hao H-X; Semplici F; Rutter J; Rutter GA. (1 Mar 2007). Phosphorylation by Per-Arnt-Sim (PAS) kinase may lead to nuclear exclusion and transcriptional repression of pancreatic duodenum homeobox-1 (PDX-1). DIABETIC MEDICINE. 24:2-2. Author weblink.
  • Leclerc I; Fernandez-Millan E; Nyirenda M; Rutter GA. (1 Mar 2007). Role of AMP-activated protein kinase in glucagon secretion. DIABETIC MEDICINE. 24:1-1. Author weblink.
  • Guillemain G; Filhoulaud G; Da Silva-Xavier G; Rutter GA; Scharfmann R. (18 May 2007). Glucose is necessary for embryonic pancreatic endocrine cell differentiation. J Biol Chem. 282:15228-15237. DOI.
  • Bailey SJ; Ravier MA; Rutter GA. (Feb 2007). Glucose-dependent regulation of gamma-aminobutyric acid (GABA A) receptor expression in mouse pancreatic islet alpha-cells. Diabetes. 56:320-327. DOI.
  • Mountjoy PD; Rutter GA. (Mar 2007). Glucose sensing by hypothalamic neurones and pancreatic islet cells: AMPle evidence for common mechanisms?. Exp Physiol. 92:311-319. DOI.
  • Mountjoy PD; Bailey SJ; Rutter GA. (Jan 2007). Inhibition by glucose or leptin of hypothalamic neurons expressing neuropeptide Y requires changes in AMP-activated protein kinase activity. Diabetologia. 50:168-177. DOI.
  • Rutter GA; Loder MK; Ravier MA. (Nov 2006). Rapid three-dimensional imaging of individual insulin release events by Nipkow disc confocal microscopy. Biochem Soc Trans. 34:675-678. DOI.
  • An R; da Silva Xavier G; Hao HX; Semplici F; Rutter J; Rutter GA. (Nov 2006). Regulation by Per-Arnt-Sim (PAS) kinase of pancreatic duodenal homeobox-1 nuclear import in pancreatic beta-cells. Biochem Soc Trans. 34:791-793. DOI.
  • McKinnon CM; Ravier MA; Rutter GA. (22 Dec 2006). FoxO1 is required for the regulation of preproglucagon gene expression by insulin in pancreatic alphaTC1-9 cells. J Biol Chem. 281:39358-39369. DOI.
  • Rutter GA; Tsuboi T; Ravier MA. (Nov 2006). Ca2+ microdomains and the control of insulin secretion. Cell Calcium. 40:539-551. DOI.
  • Rutter GA; Burnett P; Rizzuto R; Brini M; Murgia M; Pozzan T; Tavaré JM; Denton RM. (28 May 1996). Subcellular imaging of intramitochondrial Ca2+ with recombinant targeted aequorin: significance for the regulation of pyruvate dehydrogenase activity. Proc Natl Acad Sci U S A. 93:5489-5494.
  • da Silva Xavier G; Varadi A; Ainscow EK; Rutter GA. (17 Nov 2000). Regulation of gene expression by glucose in pancreatic beta -cells (MIN6) via insulin secretion and activation of phosphatidylinositol 3'-kinase. J Biol Chem. 275:36269-36277. DOI.
  • Mitchell KJ; Lai FA; Rutter GA. (28 Mar 2003). Ryanodine receptor type I and nicotinic acid adenine dinucleotide phosphate receptors mediate Ca2+ release from insulin-containing vesicles in living pancreatic beta-cells (MIN6). J Biol Chem. 278:11057-11064. DOI.
  • Rutter GA. (15 Jul 2003). Calcium signalling: NAADP comes out of the shadows. Biochem J. 373:e3-e4. DOI.
  • Rencurel F; Foretz M; Kaufmann MR; Stroka D; Looser R; Leclerc I; da Silva Xavier G; Rutter GA; et alViollet B; Meyer UA. (Dec 2006). Stimulation of AMP-activated protein kinase is essential for the induction of drug metabolizing enzymes by phenobarbital in human and mouse liver. Mol Pharmacol. 70:1925-1934. DOI.
  • MIDGLEY PJW; RUTTER GA; THOMAS AP; DENTON RM. (1 Oct 1987). THE CONTROL OF PYRUVATE-DEHYDROGENASE PHOSPHATE PHOSPHATASE BY CA-2+ AND MG-2+ IONS. BIOCHEMICAL SOCIETY TRANSACTIONS. 15:835-836. Author weblink.
  • RUTTER GA; MIDGLEY PJW; DENTON RM. (1 Oct 1987). REGULATION OF 2-OXOGLUTARATE DEHYDROGENASE AND NAD-LINKED ISOCITRATE DEHYDROGENASE WITHIN TOLUENE-PERMEABILIZED MITOCHONDRIA. BIOCHEMICAL SOCIETY TRANSACTIONS. 15:834-835. Author weblink.
  • RUTTER GA. (1 Aug 1988). CORRECTION. BIOCHEMICAL JOURNAL. 253:935-935. Author weblink.
  • RUTTER GA; DENTON RM. (1 Oct 1988). RAPID PURIFICATION AND PROPERTIES OF PIG-HEART NAD+-ISOCITRATE DEHYDROGENASE. BIOCHEMICAL SOCIETY TRANSACTIONS. 16:873-874. Author weblink.
  • DENTON RM; RUTTER GA; MIDGLEY PJW; MCCORMACK JG. (1 Jan 1988). EFFECTS OF CA-2+ ON THE ACTIVITIES OF THE CALCIUM-SENSITIVE DEHYDROGENASES WITHIN THE MITOCHONDRIA OF MAMMALIAN-TISSUES. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY. 12:S69-S72. Author weblink.
  • DENTON RM; MCCORMACK JG; MIDGLEY PJW; RUTTER GA. (1 Jan 1987). HORMONAL-REGULATION OF FLUXES THROUGH PYRUVATE-DEHYDROGENASE AND THE CITRIC-ACID CYCLE IN MAMMALIAN-TISSUES. BIOCHEMICAL SOCIETY SYMPOSIUM. 127-143. Author weblink.
  • RUTTER GA; BORTHWICK AC; DENTON RM. (15 Jun 1991). EFFECTS OF PROTEIN PHOSPHATASE INHIBITORS ON THE REGULATION OF INSULIN-SENSITIVE ENZYMES WITHIN RAT EPIDIDYMAL FAT-PADS AND CELLS. BIOCHEMICAL JOURNAL. 276:649-654. Author weblink.
  • RUTTER GA; DENTON RM. (15 Jan 1992). EFFECTS OF INSULIN AND GUANOSINE 5'-[GAMMA-THIO]TRIPHOSPHATE ON FATTY-ACID SYNTHESIS AND LIPOLYSIS WITHIN ELECTROPERMEABILIZED FAT-CELLS. BIOCHEMICAL JOURNAL. 281:431-435. Author weblink.
  • RUTTER GA; DIGGLE TA; DENTON RM. (15 Jul 1992). REGULATION OF PYRUVATE-DEHYDROGENASE BY INSULIN AND POLYAMINES WITHIN ELECTROPERMEABILIZED FAT-CELLS AND ISOLATED-MITOCHONDRIA. BIOCHEMICAL JOURNAL. 285:435-439. Author weblink.
  • RUTTER GA; LI G; PRALONG WF; WOLLHEIM CB. (1 Aug 1992). ALTERED SECRETORY RESPONSES OF INS-1 AND RINM5F CELLS ARE ASSOCIATED WITH DIFFERENCES IN INSP3 RECEPTOR FUNCTION. DIABETOLOGIA. 35:A99-A99. Author weblink.
  • SEKINE N; RUTTER GA; PRALONG WF; WOLLHEIM CB. (1 Aug 1993). EVALUATION OF NUTRIENT METABOLISM BY THE MTT TEST AND ITS CORRELATION TO INSULIN RELEASE IN INS-1 CELLS. DIABETOLOGIA. 36:A75-A75. Author weblink.
  • SEKINE N; CIRULLI V; REGAZZI R; BROWN LJ; GINE E; TAMARITRODRIGUEZ J; GIROTTI M; MARIE S; et alMACDONALD MJ; WOLLHEIM CB; RUTTER GA. (18 Feb 1994). LOW LACTATE-DEHYDROGENASE AND HIGH MITOCHONDRIAL GLYCEROL PHOSPHATE DEHYDROGENASE IN PANCREATIC BETA-CELLS - POTENTIAL ROLE IN NUTRIENT SENSING. JOURNAL OF BIOLOGICAL CHEMISTRY. 269:4895-4902. Author weblink.
  • RUTTER GA; GIROTTI M; SOOD T; KEYSE S; TAVARE J. (1 Aug 1994). MAP KINASE IS ESSENTIAL FOR SIGNALING FROM THE INSULIN-RECEPTOR TO THE NUCLEUS. DIABETOLOGIA. 37:A31-A31. Author weblink.
  • RUTTER GA; WHITE MRH; TAVARE JM. (1 Sep 1995). INVOLVEMENT OF MAP KINASE IN INSULIN SIGNALING REVEALED BY NONINVASIVE IMAGING OF LUCIFERASE GENE-EXPRESSION IN SINGLE LIVING CELLS (VOL 5, PG 890, 1995). CURRENT BIOLOGY. 5:1072-1072. Author weblink.
  • Rutter GA; Burnett P; Brini M; Pozzan T; Tavare JM; Denton RM; Rizzuto R. (1 May 1996). Imaging intramitochondrial Ca2+ in Chinese hamster ovary cells with recombinant target ed aequorin. JOURNAL OF PHYSIOLOGY-LONDON. 493P:P16-P17. Author weblink.
  • Rutter GA; Kahn A. (1 Aug 1996). Real-time imaging of the activation by glucose of the L-pyruvate kinase promoter in single clonal beta cells. DIABETOLOGIA. 39:141-141. Author weblink.
  • Pouli A; Mitra L; Schofield JG; Rutter GA. (1 Aug 1996). Expression in single clonal beta-cells of a recombinant chimaera between insulin and firefly luciferase: Towards real-time digital imaging of insulin trafficking and release. DIABETOLOGIA. 39:114-114. Author weblink.
  • Pouli AE; Kennedy HJ; Schofield JG; Rutter GA. (15 Apr 1998). Insulin targeting to the regulated secretory pathway after fusion with green fluorescent protein and firefly luciferase. BIOCHEMICAL JOURNAL. 331:669-675. Author weblink.
  • Zhao C; Rutter GA. (1 Aug 1998). Over-expression of lactate dehydrogenase A inhibits glucose-induced insulin secretion in MIN6 beta-cells. DIABETOLOGIA. 41:A145-A145. Author weblink.
  • Rafiq I; Rutter GA. (1 Aug 1998). Glucose-dependent translocation of insulin promoter factor-1 in MIN6 beta-cells. DIABETOLOGIA. 41:A47-A47. Author weblink.
  • Pouli AE; Emmanouilidou E; Zhao C; Wasmeier C; Hutton JC; Rutter GA. (1 Aug 1998). Visualising insulin secretory granule dynamics with a phogrin green fluorescent protein chimara. DIABETOLOGIA. 41:A36-A36. Author weblink.
  • Rutter GA; Kennedy HJ; Pouli AE. (1 Aug 1998). Dynamic imaging of sub-plasma membrane [ATP] in beta-cells with a SNAP25. Firefly luciferase chimaera. DIABETOLOGIA. 41:A13-A13. Author weblink.
  • Ainscow EK; Zhao C; Rutter GA. (1 Aug 1999). Pivitol role of lactate dehydrogenase activity in the control of mitochondrial metabolism of MIN6 beta-cells. DIABETOLOGIA. 42:A140-A140. Author weblink.
  • Rutter GA; Emmanouilidou E; Teschemacher AG; Seward E; Pouli AE. (1 Aug 1999). Imaging [Ca2+] in the immediate vicinity of secretory vesicles with targeted cameleons. DIABETOLOGIA. 42:A65-A65. Author weblink.
  • Renstrom E; Barg S; Seward E; Rorsman P; Rutter GA. (1 Aug 1999). Role for [Ca2+] microdomains in glucose-induced movement of GFP-tagged secretory granules. DIABETOLOGIA. 42:A36-A36. Author weblink.
  • Xavier GD; Rutter GA. (1 Aug 2000). Role of insulin release in the stimulation by glucose of the L-type pyruvate kinase gene in single MIN6 beta cells. DIABETOLOGIA. 43:A120-A120. Author weblink.
  • Mitchell K; Jones A; Varadi A; Brini M; Rizzuto R; Rutter GA. (1 Aug 2000). Imaging Ca2+ concentration changes in the matrix of secretory vesicles in insulin secreting cells. DIABETOLOGIA. 43:A118-A118. Author weblink.
  • Ainscow EK; Rutter GA. (1 Aug 2000). Elevated mitochondrial [Ca2+] provokes a long-lived potentiation of glucose metabolism in islet beta-cells. DIABETOLOGIA. 43:A44-A44. Author weblink.
  • Nicholls LI; Ainscow EK; Rutter GA. (1 Aug 2000). Effects of manipulation of pyruvate dehydrogenase (PDH) activity in MIN6 cells using recombinant PDH phosphatase (PDP) and PDH kinase (PDK). DIABETOLOGIA. 43:A43-A43. Author weblink.
  • Varadi A; Rutter GA. (1 Aug 2000). Imaging Ca2+ concentration changes in the endoplasmic reticulum of single beta-cells with targeted cameleons. DIABETOLOGIA. 43:A11-A11. Author weblink.
  • Porcelli AM; Pinton P; Ainscow EK; Chiesa A; Rugolo M; Rutter GA; Rizzuto R. (1 Jan 2001). Targeting of reporter molecules to mitochondria to measure calcium, ATP, and pH. METHODS IN CELL BIOLOGY, VOL 65. 65:353-+. Author weblink DOI.
  • Ainscow EK; Mirshamsi S; Ashford MLJ; Rutter GA. (1 Aug 2001). Distinct responses to glucose of free ATP concentration imaged dynamically in hypothalamic neurones and glial cells. DIABETOLOGIA. 44:A169-A169. Author weblink.
  • Mitchell K; Varadi A; Ainscow E; Pinton P; Pozzan T; Rizzuto R; Rutter GA. (1 Aug 2001). In vivo imaging of ryanodine receptor-mediated calcium release from dense core secretary vesicles in insulin secreting cells. DIABETOLOGIA. 44:A133-A133. Author weblink.
  • Andreolas C; Zhao C; Xavier GD; Varadi A; Foufelle F; Ferre P; Diraison F; Rutter GA. (1 Aug 2001). Sterol regulatory element binding protein 1c (SREBP-1c) is regulated by glucose at the transcriptional level in MIN6 beta cell line. DIABETOLOGIA. 44:A31-A31. Author weblink.
  • Varadi A; Rutter GA. (1 Feb 2002). Dynamic imaging of endoplasmic reticulum Ca2+ concentration in insulin-secreting MIN6 cells using recombinant targeted cameleons - Roles of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)-2 and ryanodine receptors. DIABETES. 51:S190-S201. Author weblink DOI.
  • Tsuboi T; Pinton P; Rizzuto R; Pozzan T; Ainscow EK; Rutter GA. (1 Jun 2002). Role of localized sub-plasma membrane increases in Ca2+ concentration, detected with a SNAP25. Pericam chimaera, in the membrane translocation of protein kinase C beta II. DIABETES. 51:A71-A71. Author weblink.
  • Xavier GD; Leclerc I; Rutter GA. (1 Jun 2002). Glucose-regulated gene expression via inhibition of AMP-activated protein kinase and activated insulin secretion in MIN6 pancreatic beta cells. DIABETES. 51:A2-A2. Author weblink.
  • Xavier GD; Qian Q; Cullen PJ; Rutter GA. (1 Nov 2004). Distinct roles for insulin and insulin-like growth factor-1 receptors in pancreatic beta-cell glucose sensing revealed by RNA silencing (vol 377, pg 149, 2004). BIOCHEMICAL JOURNAL. 383:599-599. Author weblink.
  • Denton RM; McCormack JG; Midgley PJ; Rutter GA. (1987). Hormonal regulation of fluxes through pyruvate dehydrogenase and the citric acid cycle in mammalian tissues. Biochem Soc Symp. 54:127-143.
  • Midgley PJ; Rutter GA; Thomas AP; Denton RM. (15 Jan 1987). Effects of Ca2+ and Mg2+ on the activity of pyruvate dehydrogenase phosphate phosphatase within toluene-permeabilized mitochondria. Biochem J. 241:371-377.
  • Denton RM; Rutter GA; Midgley PJ; McCormack JG. (1988). Effects of Ca2+ on the activities of the calcium-sensitive dehydrogenases within the mitochondria of mammalian tissues. J Cardiovasc Pharmacol. 12 Suppl 5:S69-S72.
  • Denton RM; McCormack JG; Midgley PJ; Rutter GA; Thomas AP. (1988). The role of Ca2+ in the hormonal control of intramitochondrial metabolism in heart, liver, and adipose tissue. Adv Second Messenger Phosphoprotein Res. 21:157-164.
  • Rutter GA; Denton RM. (15 May 1988). Regulation of NAD+-linked isocitrate dehydrogenase and 2-oxoglutarate dehydrogenase by Ca2+ ions within toluene-permeabilized rat heart mitochondria. Interactions with regulation by adenine nucleotides and NADH/NAD+ ratios. Biochem J. 252:181-189.
  • Rutter GA; McCormack JG; Midgley PJ; Denton RM. (1989). The role of Ca2+ in the hormonal regulation of the activities of pyruvate dehydrogenase and oxoglutarate dehydrogenase complexes. Ann N Y Acad Sci. 573:206-217.
  • Denton RM; Midgley PJ; Rutter GA; Thomas AP; McCormack JG. (1989). Studies into the mechanism whereby insulin activates pyruvate dehydrogenase complex in adipose tissue. Ann N Y Acad Sci. 573:285-296.
  • Rutter GA; Denton RM. (15 Oct 1989). Rapid purification of pig heart NAD+-isocitrate dehydrogenase. Studies on the regulation of activity by Ca2+, adenine nucleotides, Mg2+ and other metal ions. Biochem J. 263:445-452.
  • Rutter GA; Denton RM. (15 Oct 1989). The binding of Ca2+ ions to pig heart NAD+-isocitrate dehydrogenase and the 2-oxoglutarate dehydrogenase complex. Biochem J. 263:453-462.
  • Rutter GA; Midgley PJ; Denton RM. (14 Dec 1989). Regulation of the pyruvate dehydrogenase complex by Ca2+ within toluene-permeabilized heart mitochondria. Biochim Biophys Acta. 1014:263-270.
  • Rutter GA. (1990). Ca2(+)-binding to citrate cycle dehydrogenases. Int J Biochem. 22:1081-1088.
  • Rutter GA; Osbaldeston NJ; McCormack JG; Denton RM. (Oct 1990). Measurement of matrix Mg2+ concentration of rat heart mitochondria using fluorescent probes. Biochem Soc Trans. 18:894-895.
  • Rutter GA; Osbaldeston NJ; McCormack JG; Denton RM. (1 Nov 1990). Measurement of matrix free Mg2+ concentration in rat heart mitochondria by using entrapped fluorescent probes. Biochem J. 271:627-634.
  • Rutter GA; Borthwick AC; Denton RM. (15 Jun 1991). Effects of protein phosphatase inhibitors on the regulation of insulin-sensitive enzymes within rat epididymal fat-pads and cells. Biochem J. 276 ( Pt 3):649-654.
  • Rutter GA; Denton RM. (15 Jan 1992). Effects of insulin and guanosine 5'-[gamma-thio]triphosphate on fatty acid synthesis and lipolysis within electropermeabilized fat-cells. Biochem J. 281 ( Pt 2):431-435.
  • McCormack JG; Daniel RL; Osbaldeston NJ; Rutter GA; Denton RM. (Feb 1992). Mitochondrial Ca2+ transport and the role of matrix Ca2+ in mammalian tissues. Biochem Soc Trans. 20:153-159.
  • Rutter GA; Diggle TA; Denton RM. (15 Jul 1992). Regulation of pyruvate dehydrogenase by insulin and polyamines within electropermeabilized fat-cells and isolated mitochondria. Biochem J. 285 ( Pt 2):435-439.
  • Rutter GA; Pralong WF; Wollheim CB. (15 Dec 1992). Regulation of mitochondrial glycerol-phosphate dehydrogenase by Ca2+ within electropermeabilized insulin-secreting cells (INS-1). Biochim Biophys Acta. 1175:107-113.
  • Rutter GA; Theler JM; Murgia M; Wollheim CB; Pozzan T; Rizzuto R. (25 Oct 1993). Stimulated Ca2+ influx raises mitochondrial free Ca2+ to supramicromolar levels in a pancreatic beta-cell line. Possible role in glucose and agonist-induced insulin secretion. J Biol Chem. 268:22385-22390.
  • Rutter GA; Theler JM; Li G; Wollheim CB. (Aug 1994). Ca2+ stores in insulin-secreting cells: lack of effect of cADP ribose. Cell Calcium. 16:71-80.
  • Rutter GA; White MR; Tavaré JM. (1 Aug 1995). Involvement of MAP kinase in insulin signalling revealed by non-invasive imaging of luciferase gene expression in single living cells. Curr Biol. 5:890-899.
  • Denton RM; McCormack JG; Rutter GA; Burnett P; Edgell NJ; Moule SK; Diggle TA. (1996). The hormonal regulation of pyruvate dehydrogenase complex. Adv Enzyme Regul. 36:183-198.
  • Tavaré JM; Rutter GA; Griffiths MR; Dobson SP; Gray H. (May 1996). Regulation of gene expression by insulin: analysis in single living cells. Biochem Soc Trans. 24:378-384.
  • Birch HL; Rutter GA; Goodship AE. (Mar 1997). Oxidative energy metabolism in equine tendon cells. Res Vet Sci. 62:93-97.
  • Kennedy HJ; Viollet B; Rafiq I; Kahn A; Rutter GA. (15 Aug 1997). Upstream stimulatory factor-2 (USF2) activity is required for glucose stimulation of L-pyruvate kinase promoter activity in single living islet beta-cells. J Biol Chem. 272:20636-20640.
  • Pouli AE; Karagenc N; Wasmeier C; Hutton JC; Bright N; Arden S; Schofield JG; Rutter GA. (15 Mar 1998). A phogrin-aequorin chimaera to image free Ca2+ in the vicinity of secretory granules. Biochem J. 330 ( Pt 3):1399-1404.
  • Pouli AE; Emmanouilidou E; Zhao C; Wasmeier C; Hutton JC; Rutter GA. (1 Jul 1998). Secretory-granule dynamics visualized in vivo with a phogrin-green fluorescent protein chimaera. Biochem J. 333 ( Pt 1):193-199.
  • Zhao C; Rutter GA. (3 Jul 1998). Overexpression of lactate dehydrogenase A attenuates glucose-induced insulin secretion in stable MIN-6 beta-cell lines. FEBS Lett. 430:213-216.
  • Robb-Gaspers LD; Rutter GA; Burnett P; Hajnóczky G; Denton RM; Thomas AP. (10 Aug 1998). Coupling between cytosolic and mitochondrial calcium oscillations: role in the regulation of hepatic metabolism. Biochim Biophys Acta. 1366:17-32.
  • Rafiq I; Kennedy HJ; Rutter GA. (4 Sep 1998). Glucose-dependent translocation of insulin promoter factor-1 (IPF-1) between the nuclear periphery and the nucleoplasm of single MIN6 beta-cells. J Biol Chem. 273:23241-23247.
  • Robb-Gaspers LD; Burnett P; Rutter GA; Denton RM; Rizzuto R; Thomas AP. (1 Sep 1998). Integrating cytosolic calcium signals into mitochondrial metabolic responses. EMBO J. 17:4987-5000. DOI.
  • Griffiths EJ; Ocampo CJ; Savage JS; Rutter GA; Hansford RG; Stern MD; Silverman HS. (Aug 1998). Mitochondrial calcium transporting pathways during hypoxia and reoxygenation in single rat cardiomyocytes. Cardiovasc Res. 39:423-433.
  • Rutter GA; Kennedy HJ; Wood CD; White MR; Tavaré JM. (Nov 1998). Real-time imaging of gene expression in single living cells. Chem Biol. 5:R285-R290.
  • Rutter GA; Fasolato C; Rizzuto R. (30 Dec 1998). Calcium and organelles: a two-sided story. Biochem Biophys Res Commun. 253:549-557. DOI.
  • Kennedy HJ; Pouli AE; Ainscow EK; Jouaville LS; Rizzuto R; Rutter GA. (7 May 1999). Glucose generates sub-plasma membrane ATP microdomains in single islet beta-cells. Potential role for strategically located mitochondria. J Biol Chem. 274:13281-13291.
  • Rutter GA. (17 Jun 1999). Insulin secretion: feed-forward control of insulin biosynthesis?. Curr Biol. 9:R443-R445.
  • Kennedy HJ; Rafiq I; Pouli AE; Rutter GA. (1 Sep 1999). Glucose enhances insulin promoter activity in MIN6 beta-cells independently of changes in intracellular Ca2+ concentration and insulin secretion. Biochem J. 342 ( Pt 2):275-280.
  • Emmanouilidou E; Teschemacher AG; Pouli AE; Nicholls LI; Seward EP; Rutter GA. (26 Aug 1999). Imaging Ca2+ concentration changes at the secretory vesicle surface with a recombinant targeted cameleon. Curr Biol. 9:915-918.
  • Freeman DJ; Leclerc I; Rutter GA. (Dec 1999). Present and potential future use of gene therapy for the treatment of non-insulin dependent diabetes mellitus (Review). Int J Mol Med. 4:585-592.
  • Jouaville LS; Pinton P; Bastianutto C; Rutter GA; Rizzuto R. (23 Nov 1999). Regulation of mitochondrial ATP synthesis by calcium: evidence for a long-term metabolic priming. Proc Natl Acad Sci U S A. 96:13807-13812.
  • da Silva Xavier G; Leclerc I; Salt IP; Doiron B; Hardie DG; Kahn A; Rutter GA. (11 Apr 2000). Role of AMP-activated protein kinase in the regulation by glucose of islet beta cell gene expression. Proc Natl Acad Sci U S A. 97:4023-4028.
  • Rutter GA; Rizzuto R. (May 2000). Regulation of mitochondrial metabolism by ER Ca2+ release: an intimate connection. Trends Biochem Sci. 25:215-221.
  • Rafiq I; da Silva Xavier G; Hooper S; Rutter GA. (26 May 2000). Glucose-stimulated preproinsulin gene expression and nuclear trans-location of pancreatic duodenum homeobox-1 require activation of phosphatidylinositol 3-kinase but not p38 MAPK/SAPK2. J Biol Chem. 275:15977-15984.
  • Ainscow EK; Zhao C; Rutter GA. (Jul 2000). Acute overexpression of lactate dehydrogenase-A perturbs beta-cell mitochondrial metabolism and insulin secretion. Diabetes. 49:1149-1155.
  • Rutter GA. (19 Oct 2000). Diabetes: the importance of the liver. Curr Biol. 10:R736-R738.
  • Tsuboi T; Zhao C; Terakawa S; Rutter GA. (19 Oct 2000). Simultaneous evanescent wave imaging of insulin vesicle membrane and cargo during a single exocytotic event. Curr Biol. 10:1307-1310.
  • Ainscow EK; Rutter GA. (15 Jan 2001). Mitochondrial priming modifies Ca2+ oscillations and insulin secretion in pancreatic islets. Biochem J. 353:175-180.
  • Zhao C; Wilson MC; Schuit F; Halestrap AP; Rutter GA. (Feb 2001). Expression and distribution of lactate/monocarboxylate transporter isoforms in pancreatic islets and the exocrine pancreas. Diabetes. 50:361-366.
  • Porcelli AM; Pinton P; Ainscow EK; Chiesa A; Rugolo M; Rutter GA; Rizzuto R. (2001). Targeting of reporter molecules to mitochondria to measure calcium, ATP, and pH. Methods Cell Biol. 65:353-380.
  • Rutter GA; Tavaré JM; Palmer DG. (Jun 2000). Regulation of Mammalian Gene Expression by Glucose. News Physiol Sci. 15:149-154.
  • Mitchell KJ; Pinton P; Varadi A; Tacchetti C; Ainscow EK; Pozzan T; Rizzuto R; Rutter GA. (1 Oct 2001). Dense core secretory vesicles revealed as a dynamic Ca(2+) store in neuroendocrine cells with a vesicle-associated membrane protein aequorin chimaera. J Cell Biol. 155:41-51. DOI.
  • Ainscow EK; Rutter GA. (Feb 2002). Glucose-stimulated oscillations in free cytosolic ATP concentration imaged in single islet beta-cells: evidence for a Ca2+-dependent mechanism. Diabetes. 51 Suppl 1:S162-S170.
  • Palmer DG; Rutter GA; Tavaré JM. (1 Mar 2002). Insulin-stimulated fatty acid synthase gene expression does not require increased sterol response element binding protein 1 transcription in primary adipocytes. Biochem Biophys Res Commun. 291:439-443. DOI.
  • Nicholls LI; Ainscow EK; Rutter GA. (8 Mar 2002). Glucose-stimulated insulin secretion does not require activation of pyruvate dehydrogenase: impact of adenovirus-mediated overexpression of PDH kinase and PDH phosphate phosphatase in pancreatic islets. Biochem Biophys Res Commun. 291:1081-1088. DOI.
  • Rutter GA. (Dec 2001). Nutrient-secretion coupling in the pancreatic islet beta-cell: recent advances. Mol Aspects Med. 22:247-284.
  • Leclerc I; Viollet B; da Silva Xavier G; Kahn A; Rutter GA. (Apr 2002). Role of AMP-activated protein kinase in the regulation of gene transcription. Biochem Soc Trans. 30:307-311.
  • Varadi A; Ainscow EK; Allan VJ; Rutter GA. (Apr 2002). Molecular mechanisms involved in secretory vesicle recruitment to the plasma membrane in beta-cells. Biochem Soc Trans. 30:328-332.
  • Leclerc I; da Silva Xavier G; Rutter GA. (2002). AMP- and stress-activated protein kinases: key regulators of glucose-dependent gene transcription in mammalian cells?. Prog Nucleic Acid Res Mol Biol. 71:69-90.
  • Váradi A; Rutter GA. (2002). Green fluorescent protein calcium biosensors. Calcium imaging with GFP cameleons. Methods Mol Biol. 183:255-264. DOI.
  • Andreolas C; da Silva Xavier G; Diraison F; Zhao C; Varadi A; Lopez-Casillas F; Ferré P; Foufelle F; et alRutter GA. (Aug 2002). Stimulation of acetyl-CoA carboxylase gene expression by glucose requires insulin release and sterol regulatory element binding protein 1c in pancreatic MIN6 beta-cells. Diabetes. 51:2536-2545.
  • Pinton P; Tsuboi T; Ainscow EK; Pozzan T; Rizzuto R; Rutter GA. (4 Oct 2002). Dynamics of glucose-induced membrane recruitment of protein kinase C beta II in living pancreatic islet beta-cells. J Biol Chem. 277:37702-37710. DOI.
  • Varadi A; Ainscow EK; Allan VJ; Rutter GA. (1 Nov 2002). Involvement of conventional kinesin in glucose-stimulated secretory granule movements and exocytosis in clonal pancreatic beta-cells. J Cell Sci. 115:4177-4189.
  • Ainscow EK; Mirshamsi S; Tang T; Ashford ML; Rutter GA. (15 Oct 2002). Dynamic imaging of free cytosolic ATP concentration during fuel sensing by rat hypothalamic neurones: evidence for ATP-independent control of ATP-sensitive K(+) channels. J Physiol. 544:429-445.
  • Tsuboi T; da Silva Xavier G; Holz GG; Jouaville LS; Thomas AP; Rutter GA. (15 Jan 2003). Glucagon-like peptide-1 mobilizes intracellular Ca2+ and stimulates mitochondrial ATP synthesis in pancreatic MIN6 beta-cells. Biochem J. 369:287-299. DOI.
  • da Silva Xavier G; Leclerc I; Varadi A; Tsuboi T; Moule SK; Rutter GA. (1 May 2003). Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression. Biochem J. 371:761-774. DOI.
  • Eto K; Yamashita T; Hirose K; Tsubamoto Y; Ainscow EK; Rutter GA; Kimura S; Noda M; et alIino M; Kadowaki T. (Aug 2003). Glucose metabolism and glutamate analog acutely alkalinize pH of insulin secretory vesicles of pancreatic beta-cells. Am J Physiol Endocrinol Metab. 285:E262-E271. DOI.
  • Tsuboi T; Rutter GA. (1 Apr 2003). Multiple forms of "kiss-and-run" exocytosis revealed by evanescent wave microscopy. Curr Biol. 13:563-567.
  • Rutter GA. (13 May 2003). Insulin secretion: fatty acid signalling via serpentine receptors. Curr Biol. 13:R403-R405.
  • Rutter GA; Da Silva Xavier G; Leclerc I. (1 Oct 2003). Roles of 5'-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis. Biochem J. 375:1-16. DOI.
  • Tsuboi T; Rutter GA. (Aug 2003). Insulin secretion by 'kiss-and-run' exocytosis in clonal pancreatic islet beta-cells. Biochem Soc Trans. 31:833-836.
  • Tsuboi T; da Silva Xavier G; Leclerc I; Rutter GA. (26 Dec 2003). 5'-AMP-activated protein kinase controls insulin-containing secretory vesicle dynamics. J Biol Chem. 278:52042-52051. DOI.
  • Da Silva Xavier G; Qian Q; Cullen PJ; Rutter GA. (1 Jan 2004). Distinct roles for insulin and insulin-like growth factor-1 receptors in pancreatic beta-cell glucose sensing revealed by RNA silencing. Biochem J. 377:149-158. DOI.
  • Varadi A; Tsuboi T; Johnson-Cadwell LI; Allan VJ; Rutter GA. (14 Nov 2003). Kinesin I and cytoplasmic dynein orchestrate glucose-stimulated insulin-containing vesicle movements in clonal MIN6 beta-cells. Biochem Biophys Res Commun. 311:272-282.
  • Guillemain G; Da Silva Xavier G; Rafiq I; Leturque A; Rutter GA. (15 Feb 2004). Importin beta1 mediates the glucose-stimulated nuclear import of pancreatic and duodenal homeobox-1 in pancreatic islet beta-cells (MIN6). Biochem J. 378:219-227. DOI.
  • Tsuboi T; Lippiat JD; Ashcroft FM; Rutter GA. (6 Jan 2004). ATP-dependent interaction of the cytosolic domains of the inwardly rectifying K+ channel Kir6.2 revealed by fluorescence resonance energy transfer. Proc Natl Acad Sci U S A. 101:76-81. DOI.
  • Diraison F; Parton L; Ferré P; Foufelle F; Briscoe CP; Leclerc I; Rutter GA. (15 Mar 2004). Over-expression of sterol-regulatory-element-binding protein-1c (SREBP1c) in rat pancreatic islets induces lipogenesis and decreases glucose-stimulated insulin release: modulation by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR). Biochem J. 378:769-778. DOI.
  • Mitchell KJ; Tsuboi T; Rutter GA. (Feb 2004). Role for plasma membrane-related Ca2+-ATPase-1 (ATP2C1) in pancreatic beta-cell Ca2+ homeostasis revealed by RNA silencing. Diabetes. 53:393-400.
  • Leclerc I; Woltersdorf WW; da Silva Xavier G; Rowe RL; Cross SE; Korbutt GS; Rajotte RV; Smith R; et alRutter GA. (Jun 2004). Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion. Am J Physiol Endocrinol Metab. 286:E1023-E1031. DOI.
  • Walker SA; Kupzig S; Bouyoucef D; Davies LC; Tsuboi T; Bivona TG; Cozier GE; Lockyer PJ; et alBuckler A; Rutter GA; Allen MJ; Philips MR; Cullen PJ. (21 Apr 2004). Identification of a Ras GTPase-activating protein regulated by receptor-mediated Ca2+ oscillations. EMBO J. 23:1749-1760. DOI.
  • Rutter GA; Tsuboi T. (19 Jan 2004). Kiss and run exocytosis of dense core secretory vesicles. Neuroreport. 15:79-81.
  • Parton LE; Diraison F; Neill SE; Ghosh SK; Rubino MA; Bisi JE; Briscoe CP; Rutter GA. (Sep 2004). Impact of PPARgamma overexpression and activation on pancreatic islet gene expression profile analyzed with oligonucleotide microarrays. Am J Physiol Endocrinol Metab. 287:E390-E404. DOI.
  • da Silva Xavier G; Rutter J; Rutter GA. (1 Jun 2004). Involvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucose. Proc Natl Acad Sci U S A. 101:8319-8324. DOI.
  • Varadi A; Rutter GA. (Oct 2004). Ca2+-induced Ca2+ release in pancreatic islet beta-cells: critical evaluation of the use of endoplasmic reticulum-targeted "cameleons". Endocrinology. 145:4540-4549. DOI.
  • Visch HJ; Rutter GA; Koopman WJ; Koenderink JB; Verkaart S; de Groot T; Varadi A; Mitchell KJ; et alvan den Heuvel LP; Smeitink JA; Willems PH. (24 Sep 2004). Inhibition of mitochondrial Na+-Ca2+ exchange restores agonist-induced ATP production and Ca2+ handling in human complex I deficiency. J Biol Chem. 279:40328-40336. DOI.
  • Ma D; Shield JP; Dean W; Leclerc I; Knauf C; Burcelin R R; Rutter GA; Kelsey G. (Aug 2004). Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDM. J Clin Invest. 114:339-348. DOI.
  • Rutter GA; Leclerc I; Tsuboi T; Xavier GDAS; Diraison F; Qian Q. (2004). Imaging glucose-regulated insulin secretion and gene expression in single islet beta-cells: control by AMP-activated protein kinase. Cell Biochem Biophys. 40:179-190.
  • Varadi A; Johnson-Cadwell LI; Cirulli V; Yoon Y; Allan VJ; Rutter GA. (1 Sep 2004). Cytoplasmic dynein regulates the subcellular distribution of mitochondria by controlling the recruitment of the fission factor dynamin-related protein-1. J Cell Sci. 117:4389-4400. DOI.
  • Tsuboi T; McMahon HT; Rutter GA. (5 Nov 2004). Mechanisms of dense core vesicle recapture following "kiss and run" ("cavicapture") exocytosis in insulin-secreting cells. J Biol Chem. 279:47115-47124. DOI.
  • Ivarsson R; Obermüller S; Rutter GA; Galvanovskis J; Renström E. (Oct 2004). Temperature-sensitive random insulin granule diffusion is a prerequisite for recruiting granules for release. Traffic. 5:750-762. DOI.
  • Reimann F; Williams L; da Silva Xavier G; Rutter GA; Gribble FM. (Sep 2004). Glutamine potently stimulates glucagon-like peptide-1 secretion from GLUTag cells. Diabetologia. 47:1592-1601. DOI.
  • Varadi A; Cirulli V; Rutter GA. (Dec 2004). Mitochondrial localization as a determinant of capacitative Ca2+ entry in HeLa cells. Cell Calcium. 36:499-508. DOI.
  • Rutter GA. (Nov 2004). Visualising insulin secretion. The Minkowski Lecture 2004. Diabetologia. 47:1861-1872. DOI.
  • Leclerc I; Rutter GA. (Dec 2004). AMP-activated protein kinase: a new beta-cell glucose sensor?: Regulation by amino acids and calcium ions. Diabetes. 53 Suppl 3:S67-S74.
  • Diraison F; Motakis E; Parton LE; Nason GP; Leclerc I; Rutter GA. (Dec 2004). Impact of adenoviral transduction with SREBP1c or AMPK on pancreatic islet gene expression profile: analysis with oligonucleotide microarrays. Diabetes. 53 Suppl 3:S84-S91.
  • Varadi A; Tsuboi T; Rutter GA. (Jun 2005). Myosin Va transports dense core secretory vesicles in pancreatic MIN6 beta-cells. Mol Biol Cell. 16:2670-2680. DOI.
  • Gallo A; Ceolotto G; Pinton P; Iori E; Murphy E; Rutter GA; Rizzuto R; Semplicini A; et alAvogaro A. (Apr 2005). Metformin prevents glucose-induced protein kinase C-beta2 activation in human umbilical vein endothelial cells through an antioxidant mechanism. Diabetes. 54:1123-1131.
  • Tsuboi T; Ravier MA; Xie H; Ewart MA; Gould GW; Baldwin SA; Rutter GA. (8 Jul 2005). Mammalian exocyst complex is required for the docking step of insulin vesicle exocytosis. J Biol Chem. 280:25565-25570. DOI.
  • Ravier MA; Rutter GA. (Jun 2005). Glucose or insulin, but not zinc ions, inhibit glucagon secretion from mouse pancreatic alpha-cells. Diabetes. 54:1789-1797.
  • Richards SK; Parton LE; Leclerc I; Rutter GA; Smith RM. (Nov 2005). Over-expression of AMP-activated protein kinase impairs pancreatic {beta}-cell function in vivo. J Endocrinol. 187:225-235. DOI.
  • Storto M; Capobianco L; Battaglia G; Molinaro G; Gradini R; Riozzi B; Di Mambro A; Mitchell KJ; et alBruno V; Vairetti MP; Rutter GA; Nicoletti F. (Apr 2006). Insulin secretion is controlled by mGlu5 metabotropic glutamate receptors. Mol Pharmacol. 69:1234-1241. DOI.
  • Rutter GA; Varadi A; Tsuboi T; Parton L; Ravier M. (Apr 2006). Insulin secretion in health and disease: genomics, proteomics and single vesicle dynamics. Biochem Soc Trans. 34:247-250. DOI.
  • Tsuboi T; Ravier MA; Parton LE; Rutter GA. (Apr 2006). Sustained exposure to high glucose concentrations modifies glucose signaling and the mechanics of secretory vesicle fusion in primary rat pancreatic beta-cells. Diabetes. 55:1057-1065.
  • Varadi A; Grant A; McCormack M; Nicolson T; Magistri M; Mitchell KJ; Halestrap AP; Yuan H; et alSchwappach B; Rutter GA. (12 May 2006). Intracellular ATP-sensitive K(+) channels in mouse pancreatic beta cells: against a role in organelle cation homeostasis. Diabetologia. Publisher weblink DOI.
  • Rutter GA. (Jun 2006). Moving Ca2+ from the endoplasmic reticulum to mitochondria: is spatial intimacy enough?. Biochem Soc Trans. 34:351-355. DOI.
  • Rutter GA; Hill EV. (Jun 2006). Insulin vesicle release: walk, kiss, pause ... then run. Physiology (Bethesda). 21:189-196. DOI.
  • Varadi A; Grant A; McCormack M; Nicolson T; Magistri M; Mitchell KJ; Halestrap AP; Yuan H; et alSchwappach B; Rutter GA. (Jul 2006). Intracellular ATP-sensitive K+ channels in mouse pancreatic beta cells: against a role in organelle cation homeostasis. Diabetologia. 49:1567-1577. DOI.
  • Kola B; Boscaro M; Rutter GA; Grossman AB; Korbonits M. (Jul 2006). Expanding role of AMPK in endocrinology. Trends Endocrinol Metab. 17:205-215. DOI.
  • Parton LE; McMillen PJ; Shen Y; Docherty E; Sharpe E; Diraison F; Briscoe CP; Rutter GA. (Nov 2006). Limited role for SREBP-1c in defective glucose-induced insulin secretion from Zucker diabetic fatty rat islets: a functional and gene profiling analysis. Am J Physiol Endocrinol Metab. 291:E982-E994. DOI.
  • Motakis ES; Nason GP; Fryzlewicz P; Rutter GA. (15 Oct 2006). Variance stabilization and normalization for one-color microarray data using a data-driven multiscale approach. Bioinformatics. 22:2547-2553. DOI.
  • Bell CJ; Bright NA; Rutter GA; Griffiths EJ. (22 Sep 2006). ATP regulation in adult rat cardiomyocytes: time-resolved decoding of rapid mitochondrial calcium spiking imaged with targeted photoproteins. J Biol Chem. 281:28058-28067. DOI.
  • da Silva Xavier G; Rutter GA; Diraison F; Andreolas C; Leclerc I. (Nov 2006). ChREBP binding to fatty acid synthase and L-type pyruvate kinase genes is stimulated by glucose in pancreatic beta-cells. J Lipid Res. 47:2482-2491. DOI.

Conferences

  • Noordeen NA; Meur G; Patel P; Rutter GA; Leclerc I. Carbohydrate-Responsive Element-Binding Protein (ChREBP) activity is regulated by Ca2+ ions in pancreatic beta cells via soluble resistant-related calcium binding protein (Sorcin). 46th Annual Meeting of the European-Association-for-the- Study-of-Diabetes (EASD), 20 Sep 2010 - 24 Sep 2010. 53:S91-S92. SPRINGER (1 Sep 2010).
  • Meur G; Qian Q; Xavier GDS; Tsuboi T; McKinnon C; Fletcher LM; Tavare JM; Rutter GA. Fork-head box transcription factor, FoxO1 inhibits glucose-regulated insulin gene expression in pancreatic beta cells by direct binding to the promoter region. 46th Annual Meeting of the European-Association-for-the- Study-of-Diabetes (EASD), 20 Sep 2010 - 24 Sep 2010. 53:S91-S91. SPRINGER (1 Sep 2010).
  • Tarasov AI; Ravier MA; Bellomo EA; Rutter GA. Mitochondria distinguish between fast and slow cytosolic Ca2+ oscillations in pancreatic beta cells. 46th Annual Meeting of the European-Association-for-the- Study-of-Diabetes (EASD), 20 Sep 2010 - 24 Sep 2010. 53:S92-S92. SPRINGER (1 Sep 2010).
  • Rutter GA; Pullen TJ. miR-29a, miR-29b and miR-124 contribute to pancreatic beta cell specific silencing of monocarboxylate transporter 1 (Mct1/Slc16a1). 46th Annual Meeting of the European-Association-for-the- Study-of-Diabetes (EASD), 20 Sep 2010 - 24 Sep 2010. 53:S35-S36. SPRINGER (1 Sep 2010).
  • Pullen TJ; Rutter GA. Inducible expression of Monocarboxylate Transporter 1 (Mct1/Slc16a1) in the beta cell of transgenic mice: a model of exercise induced hyperinsulinism. 46th Annual Meeting of the European-Association-for-the- Study-of-Diabetes (EASD), 20 Sep 2010 - 24 Sep 2010. 53:S36-S36. SPRINGER (1 Sep 2010).
  • Hardy AB; Wijesekara N; Bhattacharjee A; Chimienti F; Rutter GA; Wheeler MB. The Role of ZnT8 in Insulin Resistance and Type 2 Diabetes. 70th Annual Meeting of the American-Diabetes-Association, 25 Jun 2010 - 29 Jun 2010. 59:A77-A77. AMER DIABETES ASSOC (1 Jun 2010).
  • Semplici F; An R; daSilvaXavier G; Meggio F; Pagano M; Pinna LA; Rutter GA. Pancreatic duodenum homeobox-1 (PDX1) is phosphorylated in living pancreatic beta cells (MIN6) at serine 269. 45th Annual Meeting of the European-Association-for-the-Study-of-Diabetes, 30 Sep 2009 - 2 Oct 2009. 52:S172-S172. SPRINGER (1 Sep 2009). Author weblink.
  • Meur G; Rutter GA; Simon A; Harun N; Dechaume A; Bonnefond A; Virally M; Tarasov A; et alBoesgaard TW; Hansen T; Pedersen O; Gautier J-F; Froguel P; Polak M; Vaxillaire M. Mutations in the insulin gene resulting in a MODY phenotype: marked differences in clinical presentation, metabolic status and pathogenic effect through ER retention. 45th Annual Meeting of the European-Association-for-the-Study-of-Diabetes, 30 Sep 2009 - 2 Oct 2009. 52:S103-S103. SPRINGER (1 Sep 2009). Author weblink.
  • DENTON RM; MIDGLEY PJW; RUTTER GA; THOMAS AP; MCCORMACK JG. STUDIES INTO THE MECHANISM WHEREBY INSULIN ACTIVATES PYRUVATE-DEHYDROGENASE COMPLEX IN ADIPOSE-TISSUE. CONF IN HONOR OF LESTER J REED - ALPHA-KETO ACID DEHYDROGENASE COMPLEXES : ORGANIZATION, REGULATION, AND BIOMEDICAL RAMIFICATIONS, 16 Nov 1988 - 18 Nov 1988. 573:285-296. NEW YORK ACAD SCIENCES (1 Jan 1989). Author weblink DOI.
  • RUTTER GA; MCCORMACK JG; MIDGLEY PJW; DENTON RM. THE ROLE OF CA-2+ IN THE HORMONAL-REGULATION OF THE ACTIVITIES OF PYRUVATE-DEHYDROGENASE AND OXOGLUTARATE DEHYDROGENASE COMPLEXES. CONF IN HONOR OF LESTER J REED - ALPHA-KETO ACID DEHYDROGENASE COMPLEXES : ORGANIZATION, REGULATION, AND BIOMEDICAL RAMIFICATIONS, 16 Nov 1988 - 18 Nov 1988. 573:206-217. NEW YORK ACAD SCIENCES (1 Jan 1989). Author weblink DOI.
  • Sun G; Xavier GD; Riboulet-Chavey A; Taneja T; Leclerc I; Rutter GA. Over-expression of constitutively-activated or dominant-negative forms of AIMP-activated protein kinase (AMPK) selectively in the beta cells of transgenic mice exerts opposing effects on glucose tolerance. 44th Annual Meeting of the European-Association-for-the-Study-of-Diabetes. 51:S202-S202. (Sep 2008).
  • Pullen TJ; Xavier GD; Kelsey G; Rutter GA. Beta cell specific silencing of the plasma membrane monocarboxylate transporter MCT1 (SLC16A1) is not effected through methylation of its promoter. 44th Annual Meeting of the European-Association-for-the-Study-of-Diabetes. 51:S195-S195. (Sep 2008).
  • Xavier GD; McDonald RAA; Loder MK; Rutter GA. TCF7L2 regulates cell proliferation and differentiation in the developing pancreatic epithelium. 44th Annual Meeting of the European-Association-for-the-Study-of-Diabetes. 51:S17-S17. (Sep 2008).
  • Chimienti F; Wheeler MB; Nicholson TJ; Bellomo EA; Wijesekara N; Tarasov AI; Taneja T; Sladek R; et alBaldwin SA; Baldwin J; Rutter GA. Single nucleotide polymorphism rs13266634 modifies the zinc transport activity of SLC30A8/ZnT-8 in clonal pancreatic beta cells. 51:S47-S47. SPRINGER (1 Sep 2008). Author weblink.
  • Zatyka M; Bellomo EA; Permutt MA; Barrett TG; Rutter GA. Depletion of the WFS1 gene in MIN6 cells reduces the glucose induced cytoplasmic ATP rise and modulates calcium uptake by the endoplasmic reticulum. 67th Annual Meeting of the American-Diabetes-Association. 57:A54-A55. (Jun 2008).
  • Loder MK; Xavier GD; McDonald A; Rutter GA. TCF7L2 controls insulin gene expression and insulin secretion in mature pancreatic beta-cells. Biochemical-Society-Irish-Area-Section Annual Meeting on Ubiquitin and Ubiquitin-Like Modification in Health and Disease. 36:357-359. (Jun 2008).
  • Rutter GA; Wong FS. The pancreatic beta-cell: birth, life and death. Biochemical-Society-Irish-Area-Section Annual Meeting on Ubiquitin and Ubiquitin-Like Modification in Health and Disease. 36:267-271. (Jun 2008).
  • Riveline JP; Vaxillaire M; Fetita LS; Tarasov A; Nicolson T; Charpentier G; Franc S; Froguel P; et alRutter GA; Gautier JF. Metabolic consequences of a new ABCC8/SUR1 gene mutation found in adult type 2 diabetic patients and their lineage. 34:A78-A78. MASSON EDITEUR (1 Mar 2008). Author weblink.
  • Rutter GA. Generating new candidate genes for neonatal diabetes: Functional and genetic studies of insulin secretion in type 2 diabetes. 1st ESPE Advanced Seminar in Developmental Endocrinology. 12:75-85. (2007).
  • Guyot A; Evagelidis A; Gibson C; Michoud MC; Xavier GD; Martin JG; Sessions RB; Rutter GA; et alHanrahan JW. Mechanically induced fluctuations in cytosolic ATP. 21st Biennial Meeting of the International-Society-for-Neurochemistry/38th Annual Meeting of the American-Society-for-Neurochemistry. 102:245-245. (Aug 2007).
  • RUTTER GA; LEAKE MJ; MCCORMACK JG; DENTON RM. ROLE OF CA2+ AND MG2+ IN THE CONTROL OF THE PYRUVATE AND 2-OXOGLUTARATE DEHYDROGENASE COMPLEXES. INTERNATIONAL MEETING ON THE FUNCTION OF THIAMIN DIPHOSPHATE ENZYMES. 221-231. (1991).
  • Rutter GA; Nicholls L; Tsuboi T; Allen VJ; Varadi A. Cytoplasmic dynein is not the principle molecular motor involved in retrograde movement of insulin-containing vesicles. 18th Congress of the International-Diabetes-Federation. 46:A163-A164. (Aug 2003).
  • Tsuboi T; Lippiat JD; Ashcroft FM; Rutter GA. ATP-dependent interaction of the cytosolic domains of Kir6.2 revealed by fluorescence resonance energy transfer. 18th Congress of the International-Diabetes-Federation. 46:A161-A161. (Aug 2003).
  • Diraison F; Xavier GD; Motakis E; Nason GP; Rutter GA; Leclerc I. Impact of over-expression of carbohydrate response-element binding-protein (ChREBP) on pancreatic beta-cell gene expression profile and insulin secretion. 40th Annual Meeting of the European-Association-for-the-Study-of-Diabetes. 47:A162-A162. (Aug 2004).
  • Varadi A; Mitchell KJ; Tsuboi T; Schwappach B; Rutter GA. Subcellular localisation of endogenous and overexpressed ATP-sensitive K+ channel subunits SUR1 and Kir6.2 in clonal MIN6 beta-cells. 40th Annual Meeting of the European-Association-for-the-Study-of-Diabetes. 47:A155-A155. (Aug 2004).
  • Mountjoy PD; Bailey SJ; Rutter GA. Involvement of 5 '-AMP-activated protein kinase (AMPK) in glucose sensing by hypothalamic neurons. 40th Annual Meeting of the European-Association-for-the-Study-of-Diabetes. 47:A101-A102. (Aug 2004).
  • Ravier MA; Rutter GA. Independent roles for glucose and insulin in the control of glucagon secretion revealed by imaging ATP and Ca2+ with recombinant targeted probes. 40th Annual Meeting of the European-Association-for-the-Study-of-Diabetes. 47:A79-A79. (Aug 2004).
  • Rutter GA; Ma D; Shield JPH; Dean W; Leclerc I; Knauf C; Burcelin R; Kelsey G. Altered glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus (TNDM) locus. 40th Annual Meeting of the European-Association-for-the-Study-of-Diabetes. 47:A53-A54. (Aug 2004).
  • Xavier GDS; Rutter J; Rutter GA. Role of PAS kinase as a glucose sensor in pancreatic MIN6 beta cells. 40th Annual Meeting of the European-Association-for-the-Study-of-Diabetes. 47:A26-A26. (Aug 2004).
  • Guyot AM; Evagelidis A; Gibson C; Xavier GD; Rutter GA; Hanrahan JW. Luciferase mutant expressed in HEK cells reveals transmembrane ATP efflux during mechanical stimulation. Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences. 19:A659-A659. (4 Mar 2005).
  • Richards SK; LeClerc I; Mathieson PW; Morgan JDT; Rutter GA; Smith RM. The effect of AMP-activated protein kinase on success rate and glycaemic control of murine islet isografts. Annual Meeting of the Association-of-Surgeons-of-Great-Britian-and-Ireland. 92:34-34. (Apr 2005).
  • Bell CJ; Rutter GA; Griffiths EJ. Mitochondrial and cytosolic calcium transients in adult cardiomyocytes detected using targeted aequorin. 25th Annual Scientific Session of the European Section of the International-Society-Heart-Research. 38:1004-1005. (Jun 2005).
  • Ravier MA; Tillmar L; Rutter GA. Glucose-regulated plasma membrane recruitment of protein kinase C beta 11 in clonal pancreatic alpha-cells imaged by confocal and total internal reflection fluorescence microscopy. 65th Annual Meeting of the American-Diabetes-Association. 54:A406-A406. (Jan 2005).
  • McKinnon CM; Rutter GA. Regulation of glucagon gene expression by insulin is abolished after FOXO1 silencing. 41st Annual Meeting of the European-Association-for-the-Study-of-Diabetes. 48:A160-A160. (Jan 2005).
  • Xavier GD; Diraison F; Qian Q; Rutter GA; Leclerc I. Carbohydrate response-element binding protein regulates liver-type pyruvate kinase and pancreatic duodenum homeobox-1 expression in MIN6 beta-cells by direct and indirect mechanisms, respectively. 41st Annual Meeting of the European-Association-for-the-Study-of-Diabetes. 48:A157-A157. (Jan 2005).
  • Rutter GA; Richards SK; Parton LE; Leclerc I; Smith RM. Over-expression of activated AMP-activated protein kinase (AMPK) impairs in vivo pancreatic beta-cell function in transplanted pancreatic islets. 41st Annual Meeting of the European-Association-for-the-Study-of-Diabetes. 48:A88-A88. (Jan 2005).
  • Sorto M; Capobianco L; Battaglia G; Molinaro G; Genazzani AA; Gradini R; Riozzi B; Bruno V; et alVairetti M; Rutter GA; Nicoletti F. Insulin secretion is under the control of type-5 metabotropic glutamate receptors. 5th International Meeting on Metabotropic Glutamate Receptors. 49:274-274. (Jan 2005).
  • Bell CJ; Rutter GA; Griffiths EJ. Use of the mitochondrial Ca2+-transport inhibitors Ru360 and clonazepam to investigate cell Ca2+-signalling in adult cardiomyocytes: A cautionary tale. 28th Annual International-Society-for-Heart-Research North American Section Meeting. 40:924-924. (Jun 2006).
  • Xavier GDS; Rutter GA. Tef712 regulates glucose-stimulated insulin secretion and insulin gene expression in min6 beta-cells. 67th Annual Meeting of the American-Diabetes-Association. 56:A437-A437. (Jun 2007).
  • Jacquet S; Zarrinpashneh E; Chavey A; Leclerc I; Rutter GA; Bertrand L; Marber MS. The relationship between P38-MAPK and AMPK during myocardial ischaernia. 19th World Congress of the ISHR, 22 Jun 2007 - 25 Jun 2007. 42:S52-S52. ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD (1 Jun 2007). Author weblink DOI.
  • Ravier MA; Bailey SJ; Rutter GA. Regulation by glucose of GABA(A) receptor expression in mouse alpha-cells: role in the intra-islet regulation of glucagon secretion. 42nd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), 14 Sep 2006 - 17 Sep 2006. 49:283-284. SPRINGER (1 Sep 2006). Author weblink.
  • Diraison F; Ravier MA; Shimano H; Rutter GA. Sterol regulatory element binding protein1 (SRFBP1) is required for the induction by glucose of beta-cell genes involved in glucose sensing. 42nd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), 14 Sep 2006 - 17 Sep 2006. 49:88-88. SPRINGER (1 Sep 2006). Author weblink.
  • Nicholls LI; Varadi A; Ainscow EK; Allen VJ; Rutter GA. Role of an intact mitochondrial reticulum in the triggering of insulin release by glucose. 38th EASD Annual Meeting of the European-Association-for-the-Study-of-Diabetes, 1 Sep 2002 - 5 Sep 2002. 45:A170-A170. SPRINGER-VERLAG (1 Aug 2002). Author weblink.
  • Diraison F; Ferre P; Foufelle F; Rutter GA. Impact of over-expression of sterol response element binding protein-1c (SREBP-1c) on glucose-stimulated insulin secretion from rat islets. 38th EASD Annual Meeting of the European-Association-for-the-Study-of-Diabetes, 1 Sep 2002 - 5 Sep 2002. 45:A151-A151. SPRINGER-VERLAG (1 Aug 2002). Author weblink.
  • Mitchell KJ; Rutter GA. Role of plasma membrane-related Ca2+-ATPase-1 (PMR1) in islet beta-cell Ca2+ homeostasis. 18th Congress of the International-Diabetes-Federation, 24 Aug 2003 - 29 Aug 2003. 46:A158-A159. SPRINGER-VERLAG (1 Aug 2003). Author weblink.
  • Xavier GDS; Qian Q; Rutter GA. Role of insulin and insulin-like growth factor-1 receptors in glucose-regulated preproinsulin gene expression probed by RNA interference and single cell promoter analysis. 18th Congress of the International-Diabetes-Federation, 24 Aug 2003 - 29 Aug 2003. 46:A153-A153. SPRINGER-VERLAG (1 Aug 2003). Author weblink.
  • Parton LE; Smith ER; Diraison F; Tsuboi T; Rutter GA. Impact of sterol response element binding protein-1c on insulin-containing secretory vesicle dynamics. 40th Annual Meeting of the European-Association-for-the-Study-of-Diabetes, 5 Sep 2004 - 9 Sep 2004. 47:A153-A153. SPRINGER (1 Aug 2004). Author weblink.
  • Gribble FM; Williams L; Xavier GDS; Rutter GA; Reimann F. Glucagon-like peptide-1 secretion is potently stimulated by glutamine in the GLUTag cell line. 40th Annual Meeting of the European-Association-for-the-Study-of-Diabetes, 5 Sep 2004 - 9 Sep 2004. 47:A36-A36. SPRINGER (1 Aug 2004). Author weblink.
  • Richards SK; Parton LE; Leclerc I; Rutter GA; Smith RM. AMP-activated protein kinase (AMPK) activity in murine islet isografts as a determinant of recipient glycaemic control. 65th Annual Meeting of the American-Diabetes-Association, 10 Jun 2005 - 14 Jun 2005. 54:A480-A480. AMER DIABETES ASSOC (1 Jan 2005). Author weblink.
  • Diraison F; Ravier MA; Richards SK; Smith RM; Shimano H; Rutter GA. Sterol regulatory element binding protein1 (SREBP1) is required for the potentiation by culture at high glucose concentrations of glucose-stimulated insulin secretion from mouse islets. 41st Annual Meeting of the European-Association-for-the-Study-of-Diabetes, 10 Sep 2005 - 15 Sep 2005. 48:A165-A166. SPRINGER (1 Jan 2005). Author weblink.
Share this on Delicious
Tweet this
Digg this
Stumble this
Share this on Facebook