Professor Graham R Williams

Publications


Journals

  • Nicholls JJ; Brassill MJ; Williams GR; Bassett JH. (27 Mar 2012). The skeletal consequences of thyrotoxicosis. J Endocrinol. DOI.
  • O Shea PJ; Kim DW; Logan JG; Davis S; Walker RL; Meltzer PS; Cheng SY; Williams GR. (22 Mar 2012). Advanced bone formation in mice with a dominant-negative mutation in the thyroid hormone receptor β gene due to activation of Wnt/β-catenin signaling. J Biol Chem. DOI.
  • Xing W; Govoni K; Donahue LR; Kesavan C; Wergedal J; Long C; Bassett JH; Gogakos A; et alWojcicka A; Williams GR; Mohan S. (13 Jan 2012). Genetic evidence that thyroid hormone is indispensable for prepubertal IGF-I expression and bone acquisition in mice. J Bone Miner Res. DOI.
  • Bassett JH; van der Spek A; Gogakos A; Williams GR. (2012). Quantitative X-ray imaging of rodent bone by Faxitron. Methods Mol Biol. 816:499-506. DOI.
  • Murray J; Williams G; Harrington K; Newbold K; Nutting C. (15 Dec 2011). Rising Thyroglobulin Tumour Marker During Pregnancy In A Thyroid Cancer Patient: No Cause For Alarm?. Clin Endocrinol (Oxf). DOI.
  • Waung JA; Bassett JH; Williams GR. (Apr 2012). Thyroid hormone metabolism in skeletal development and adult bone maintenance. Trends Endocrinol Metab. 23:155-162. DOI.
  • Karunaratne A; Esapa CR; Hiller J; Boyde A; Head R; Bassett JH; Terrill NJ; Williams GR; et alBrown MA; Croucher PI; Brown SD; Cox RD; Barber AH; Thakker RV; Gupta HS. (Apr 2012). Significant deterioration in nanomechanical quality occurs through incomplete extrafibrillar mineralization in rachitic bone: evidence from in-situ synchrotron X-ray scattering and backscattered electron imaging. J Bone Miner Res. 27:876-890. DOI.
  • Esapa CT; Hough TA; Testori S; Head RA; Crane EA; Chan CP; Evans H; Bassett JH; et alTylzanowski P; McNally EG; Carr AJ; Boyde A; Howell PG; Clark A; Williams GR; Brown MA; Croucher PI; Nesbit MA; Brown SD; Cox RD; Cheeseman MT; Thakker RV. (Feb 2012). A mouse model for spondyloepiphyseal dysplasia congenita with secondary osteoarthritis due to a Col2a1 mutation. J Bone Miner Res. 27:413-428. DOI.
  • Vanderpump MP; Lazarus JH; Smyth PP; Laurberg P; Holder RL; Boelaert K; Franklyn JA; British Thyroid Association UK Iodine Survey Group. (11 Jun 2011). Iodine status of UK schoolgirls: a cross-sectional survey. Lancet. 377:2007-2012. DOI.
  • Williams GR. (Apr 2011). Extrathyroidal expression of TSH receptor. Ann Endocrinol (Paris). 72:68-73. DOI.
  • Combs CE; Nicholls JJ; Bassett JHD; Williams GR. (1 Mar 2011). Thyroid hormones and bone development. Minerva Endocrinologica. 36:71-85.
  • Williams GR; Bassett JH. (Jun 2011). Deiodinases: the balance of thyroid hormone: local control of thyroid hormone action: role of type 2 deiodinase. J Endocrinol. 209:261-272. DOI.
  • Hu M; Bassett JH; Danks L; Howell PG; Xu K; Spanoudakis E; Kotsianidis I; Boyde A; et alWilliams GR; Horwood N; Roberts IA; Karadimitris A. (1 Mar 2011). Activated invariant NKT cells regulate osteoclast development and function. J Immunol. 186:2910-2917. DOI.
  • Vanleene M; Saldanha Z; Cloyd KL; Jell G; Bou-Gharios G; Bassett JH; Williams GR; Fisk NM; et alOyen ML; Stevens MM; Guillot PV; Shefelbine SJ. (20 Jan 2011). Transplantation of human fetal blood stem cells in the osteogenesis imperfecta mouse leads to improvement in multiscale tissue properties. Blood. 117:1053-1060. DOI.
  • Gogakos AI; Bassett JHD; Williams GR. (1 Nov 2010). Thyroid and bone. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 503:129-136. Author weblink DOI.
  • Master A; Wojcicka A; Piekielko-Witkowska A; Boguslawska J; Poplawski P; Tanski Z; Darras VM; Williams GR; et alNauman A. (1 Nov 2010). Untranslated regions of thyroid hormone receptor beta 1 mRNA are impaired in human clear cell renal cell carcinoma. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. 1802:995-1005. DOI.
  • Murphy E; Glüer CC; Reid DM; Felsenberg D; Roux C; Eastell R; Williams GR. (Jul 2010). Thyroid function within the upper normal range is associated with reduced bone mineral density and an increased risk of nonvertebral fractures in healthy euthyroid postmenopausal women. J Clin Endocrinol Metab. 95:3173-3181. DOI.
  • Bassett JH; Boyde A; Howell PG; Bassett RH; Galliford TM; Archanco M; Evans H; Lawson MA; et alCroucher P; St Germain DL; Galton VA; Williams GR. (20 Apr 2010). Optimal bone strength and mineralization requires the type 2 iodothyronine deiodinase in osteoblasts. Proc Natl Acad Sci U S A. 107:7604-7609. DOI.
  • Williams GR. (1 Sep 2009). Actions of thyroid hormones in bone. ENDOKRYNOLOGIA POLSKA. 60:380-388. Author weblink.
  • Bassett JHD; Williams GR. (1 Mar 2009). The skeletal phenotypes of TR alpha and TR beta mutant mice. JOURNAL OF MOLECULAR ENDOCRINOLOGY. 42:269-282. Author weblink DOI.
  • Tan TM; Caputo C; Medici F; Pambakian AL; Dornhorst A; Meeran K; Williams GR; Khoo B. (Feb 2009). MELAS syndrome, diabetes and thyroid disease: the role of mitochondrial oxidative stress. Clin Endocrinol (Oxf). 70:340-341. DOI.
  • Brassill MJ; Williams GR. (2009). Advances in our understanding of hyperthyroidism-associated bone loss. European Endocrinology. 4:103-106.
  • Brassill MJ; Williams GR. (2009). Advances in our understanding of hyperthyroidism-associated bone loss. US Endocrinology. 4:114-117.
  • Han TS; Williams GR; Vanderpump MPJ. (1 Jan 2009). Benzofuran derivatives and the thyroid. CLINICAL ENDOCRINOLOGY. 70:2-13. Author weblink DOI.
  • Gogakos AI; Cheung MS; Bassett JHD; Williams GR. (2009). Bone signalling pathways and treatment of osteoporosis. Expert Reviews in Endocrinology and Metabolism. 4:639-650.
  • Williams GR. (1 Jan 2009). Does serum TSH level have thyroid hormone independent effects on bone turnover?. NATURE CLINICAL PRACTICE ENDOCRINOLOGY & METABOLISM. 5:10-11. Author weblink DOI.
  • Murphy E; Williams GR. (2009). Hypocalcaemia. Medicine. 37:465-468.
  • Hameed S; Dhillo WS; Patterson M; Bloom SR; Rashid S; Bassett JHD; Williams GR; Gardiner JV. (2009). The Central Regulation of Food Intake and Energy Expenditure by Thyroid Hormones. Hot Thyroidology (www.hotthyroidology.com.
  • Hameed S; Dhillo WS; Patterson M; Bloom SR; Rashid S; Bassett JHD; Williams GR. (2009). The central regulation of food intake and energy expenditure by thyroid hormones. Hot Thyroidology. www.hotthyroidology.com/editorial_pdf.hameed_HT08_09.pdf.
  • Bassett JHD; Williams GR. (1 Sep 2008). Critical role of the hypothalamic-pituitary-thyroid axis in bone. BONE. 43:418-426. Author weblink DOI.
  • Williams AJ; Robson H; Kester MHA; van Leeuwen JPTM; Shalet SM; Visser TJ; Williams GR. (1 Jul 2008). Iodothyronine deiodinase enzyme activities in bone. BONE. 43:126-134. Author weblink DOI.
  • Williams GR. (1 Jun 2008). Neurodevelopmental and neurophysiological actions of thyroid hormone. JOURNAL OF NEUROENDOCRINOLOGY. 20:784-794. Author weblink DOI.
  • Vaidya B; Williams GR; Abraham P; Pearce SHS. (1 May 2008). Radioiodine treatment for benign thyroid disorders: results of a nationwide survey of UK endocrinologists. CLINICAL ENDOCRINOLOGY. 68:814-820. Author weblink DOI.
  • Bassett JH; Williams AJ; Murphy E; Boyde A; Howell PG; Swinhoe R; Archanco M; Flamant F; et alSamarut J; Costagliola S; Vassart G; Weiss RE; Refetoff S; Williams GR. (Feb 2008). A lack of thyroid hormones rather than excess thyrotropin causes abnormal skeletal development in hypothyroidism. Mol Endocrinol. 22:501-512. DOI.
  • Guillot PV; Abass O; Bassett JHD; Shefelbine SJ; Bou-Gharios G; Chan J; Kurata H; Williams GR; et alPolak J; Fisk NM. (1 Feb 2008). Intrauterine transplantation of human fetal mesenchymal stem cells from first-trimester blood repairs bone and reduces fractures in osteogenesis impertecta mice. BLOOD. 111:1717-1725. Author weblink DOI.
  • Murphy E; Glueer C; Reid DM; Felsenberg D; Roux C; Easte R; Williams GR. (1 Jan 2008). Effect of thyroid status on the skeleton in post-menopausal women: The OPUS study. CALCIFIED TISSUE INTERNATIONAL. 82:S46-S46. Author weblink.
  • Ghaffar A; Bassett JHD; Williams GR. (2008). Normocalcemic primary hyperparathyroidism. Reviews in Endocrinology. 2:38-40.
  • Cegla J; Williams GR. (2008). The short synacthen test: a short survival guide. Foundation Years Journal. 2:306-308.
  • O'Shea PJ; Guigon CJ; Williams GR; Cheng S-Y. (1 Dec 2007). Regulation of fibroblast growth factor receptor-1 (Fgfr1) by thyroid hormone: Identification of a thyroid hormone response element in the murine fgfr1 promoter. ENDOCRINOLOGY. 148:5966-5976. Author weblink DOI.
  • Williams AJ; O'Shea PJ; Williams GR. (Oct 2007). Complex interactions between thyroid hormone and fibroblast growth factor signalling. Curr Opin Endocrinol Diabetes Obes. 14:410-415. DOI.
  • Perz JB; Marin D; Szydlo RM; Giles C; Olavarria E; Williams G; Apperley JF. (Oct 2007). Incidence of hyperthyroidism after unrelated donor allogeneic stem cell transplantation. Leuk Res. 31:1433-1436. DOI.
  • Bassett JH; Nordström K; Boyde A; Howell PG; Kelly S; Vennström B; Williams GR. (Aug 2007). Thyroid status during skeletal development determines adult bone structure and mineralization. Mol Endocrinol. 21:1893-1904. DOI.
  • Williams GR. (Jun 2007). Hypogonadal bone loss: sex steroids or gonadotropins?. Endocrinology. 148:2610-2612. DOI.
  • Bassett JH; O'Shea PJ; Sriskantharajah S; Rabier B; Boyde A; Howell PG; Weiss RE; Roux JP; et alMalaval L; Clement-Lacroix P; Samarut J; Chassande O; Williams GR. (May 2007). Thyroid hormone excess rather than thyrotropin deficiency induces osteoporosis in hyperthyroidism. Mol Endocrinol. 21:1095-1107. DOI.
  • Harvey CB; Bassett JH; Maruvada P; Yen PM; Williams GR. (Apr 2007). The rat thyroid hormone receptor (TR) Deltabeta3 displays cell-, TR isoform-, and thyroid hormone response element-specific actions. Endocrinology. 148:1764-1773. DOI.
  • Galliford TM; Bernstein ND; Bassett JHD; Williams GR. (2007). Contrasting roles for thyroid hormone in the developing and adult skeleton. Hot Thyroidology. www.hotthyroidology.com/editorial_172.html.
  • Rabier B; Williams AJ; Mallein-Gerin F; Williams GR; Chassande O. (1 Oct 2006). Thyroid hormone-stimulated differentiation of primary rib chondrocytes in vitro requires thyroid hormone receptor beta. JOURNAL OF ENDOCRINOLOGY. 191:221-228. Author weblink DOI.
  • Bassett JHD; O'Shea PJ; Chassande O; Samarut J; Cheng SY; Vennstrom B; Howell PGT; Boyde A; et alWilliams GR. (1 Mar 2006). Analysis of skeletal phenotypes in thyroid hormone receptor mutant mice. SCANNING. 28:91-93. Author weblink.
  • Keenan N; Dhillo WS; Williams GR; Todd JF. (4 Feb 2006). Unexpected shortness of breath in a patient with Cushing's syndrome. Lancet. 367:446. DOI.
  • O'Shea PJ; Bassett JH; Cheng SY; Williams GR. (2006). Characterization of skeletal phenotypes of TRalpha1 and TRbeta mutant mice: implications for tissue thyroid status and T3 target gene expression. Nucl Recept Signal. 4:e011. DOI.
  • Murphy E; Bassett JHD; Williams GR. (2006). Disorders of calcium metabolism. The Practitioner. 250:4-8.
  • Bassett JH; Swinhoe R; Chassande O; Samarut J; Williams GR. (Jan 2006). Thyroid hormone regulates heparan sulfate proteoglycan expression in the growth plate. Endocrinology. 147:295-305. DOI.
  • O'Shea PJ; Bassett JH; Sriskantharajah S; Ying H; Cheng SY; Williams GR. (Dec 2005). Contrasting skeletal phenotypes in mice with an identical mutation targeted to thyroid hormone receptor alpha1 or beta. Mol Endocrinol. 19:3045-3059. DOI.
  • Galliford TM; Murphy E; Williams AJ; Bassett JH; Williams GR. (Dec 2005). Effects of thyroid status on bone metabolism: a primary role for thyroid stimulating hormone or thyroid hormone?. Minerva Endocrinol. 30:237-246.
  • Barnard JC; Williams AJ; Rabier B; Chassande O; Samarut J; Cheng SY; Bassett JH; Williams GR. (Dec 2005). Thyroid hormones regulate fibroblast growth factor receptor signaling during chondrogenesis. Endocrinology. 146:5568-5580. DOI.
  • Freitas FRS; Capelo LP; O'Shea PJ; Jorgetti V; Moriscot AS; Scanlan TS; Williams GR; Zorn TMT; et alGouveia CHA. (1 Feb 2005). The thyroid hormone receptor beta-specific agonist GC-1 selectively affects the bone development of hypothyroid rats. JOURNAL OF BONE AND MINERAL RESEARCH. 20:294-304. Author weblink DOI.
  • Murphy E; Williams GR. (2005). Hypocalcaemia. Medicine. 30:55-57.
  • Maxwell PH; Williams GR. (2005). Research training in the 21st century: a role for part time MSc courses. BMJ: British Medical Journal. 330:28.
  • Barakat MT; Ashrafian H; Todd JF; Meeran K; Williams GR. (1 Oct 2004). Severe hypercalcaemia parathyroid from secretion of hormone-related peptide. LANCET ONCOLOGY. 5:633-635. Author weblink DOI.
  • Murphy E; Williams GR. (Sep 2004). The thyroid and the skeleton. Clin Endocrinol (Oxf). 61:285-298. DOI.
  • Frankton S; Harvey CB; Gleason LM; Fadel A; Williams GR. (Jul 2004). Multiple messenger ribonucleic acid variants regulate cell-specific expression of human thyroid hormone receptor beta1. Mol Endocrinol. 18:1631-1642. DOI.
  • Barakat MT; Ashrafian H; Todd JF; Boyle JJ; Lynn JA; Williams GR. (Apr 2004). Renal magnesium loss causing hypomagnesaemia and autonomous hyperparathyroidism. Nephrol Dial Transplant. 19:977-980. DOI.
  • Siebler T; Robson H; Shalet SM; Williams GR. (1 Jan 2004). Thyroid hormone and the growth plate. HORMONE RESEARCH. 62:116-116. Author weblink DOI.
  • Williams GR. (2004). Thyroid hormones, mast cells and bone. Sociedad Iberoamericano de Informacion Cientifica. www.siicsalud.com/des/des035/04115098.htm.
  • Harvey CB; Stevens DA; Williams AJ; Jackson DJ; O'Shea P; Williams GR. (31 Dec 2003). Analysis of thyroid hormone responsive gene expression in osteoblastic cells. Mol Cell Endocrinol. 213:87-97. DOI.
  • Bassett JH; Harvey CB; Williams GR. (31 Dec 2003). Mechanisms of thyroid hormone receptor-specific nuclear and extra nuclear actions. Mol Cell Endocrinol. 213:1-11. DOI.
  • Bassett JH; Williams GR. (Oct 2003). The molecular actions of thyroid hormone in bone. Trends Endocrinol Metab. 14:356-364.
  • Stevens DA; Harvey CB; Scott AJ; O'Shea PJ; Barnard JC; Williams AJ; Brady G; Samarut J; et alChassande O; Williams GR. (Sep 2003). Thyroid hormone activates fibroblast growth factor receptor-1 in bone. Mol Endocrinol. 17:1751-1766. DOI.
  • O'Shea PJ; Harvey CB; Suzuki H; Kaneshige M; Kaneshige K; Cheng SY; Williams GR. (Jul 2003). A thyrotoxic skeletal phenotype of advanced bone formation in mice with resistance to thyroid hormone. Mol Endocrinol. 17:1410-1424. DOI.
  • O'Shea PJ; Williams GR. (Dec 2002). Insight into the physiological actions of thyroid hormone receptors from genetically modified mice. J Endocrinol. 175:553-570.
  • Siebler T; Robson H; Shalet SM; Williams GR. (Oct 2002). Dexamethasone inhibits and thyroid hormone promotes differentiation of mouse chondrogenic ATDC5 cells. Bone. 31:457-464.
  • Robson H; Siebler T; Shalet SM; Williams GR. (Aug 2002). Interactions between GH, IGF-I, glucocorticoids, and thyroid hormones during skeletal growth. Pediatr Res. 52:137-147.
  • Gouveia CH; Schultz JJ; Jackson DJ; Williams GR; Brent GA. (Aug 2002). Thyroid hormone gene targets in ROS 17/2.8 osteoblast-like cells identified by differential display analysis. Thyroid. 12:663-671. DOI.
  • Harvey CB; Williams GR. (Jun 2002). Mechanism of thyroid hormone action. Thyroid. 12:441-446. DOI.
  • Siddiqi A; Parsons MP; Lewis JL; Monson JP; Williams GR; Burrin JM. (Feb 2002). TR expression and function in human bone marrow stromal and osteoblast-like cells. J Clin Endocrinol Metab. 87:906-914.
  • Harvey CB; O'Shea PJ; Scott AJ; Robson H; Siebler T; Shalet SM; Samarut J; Chassande O; et alWilliams GR. (Jan 2002). Molecular mechanisms of thyroid hormone effects on bone growth and function. Mol Genet Metab. 75:17-30. DOI.
  • Siebler T; Robson H; Bromley M; Stevens DA; Shalet SM; Williams GR. (Jan 2002). Thyroid status affects number and localization of thyroid hormone receptor expressing mast cells in bone marrow. Bone. 30:259-266.
  • Gauthier K; Plateroti M; Harvey CB; Williams GR; Weiss RE; Refetoff S; Willott JF; Sundin V; et alRoux JP; Malaval L; Hara M; Samarut J; Chassande O. (Jul 2001). Genetic analysis reveals different functions for the products of the thyroid hormone receptor alpha locus. Mol Cell Biol. 21:4748-4760. DOI.
  • Siebler T; Robson H; Shalet SM; Williams GR. (2001). Glucocorticoids, thyroid hormone and growth hormone interactions: implications for the growth plate. Horm Res. 56 Suppl 1:7-12.
  • Stevens DA; Hasserjian RP; Robson H; Siebler T; Shalet SM; Williams GR. (Dec 2000). Thyroid hormones regulate hypertrophic chondrocyte differentiation and expression of parathyroid hormone-related peptide and its receptor during endochondral bone formation. J Bone Miner Res. 15:2431-2442. DOI.
  • Williams GR. (Nov 2000). Cloning and characterization of two novel thyroid hormone receptor beta isoforms. Mol Cell Biol. 20:8329-8342.
  • Frankton S; Karmali R; Mirkine N; Bergmann P; Fuss M; Williams GR. (7 Oct 2000). Pituitary-thyroid feedback hypersensitivity as a novel cause of hypothyroidism in children. LANCET. 356:1238-1240. Author weblink DOI.
  • Robson H; Siebler T; Stevens DA; Shalet SM; Williams GR. (1 Oct 2000). Thyroid hormone acts directly on growth plate chondrocytes to promote hypertrophic differentiation and inhibit clonal expansion and cell proliferation. Endocrinology. 141:3887-3897.
  • Kindblom JM; Robson H; Stevens DA; Siebler T; Gothe S; Tornell J; Forrest D; Vennstrom B; et alWilliams GR; Ohlsson C. (1 Sep 1999). Regulation of the Ihh/PTHrP negative loop in growth plate of mice lacking all known thyroid hormone receptors. JOURNAL OF BONE AND MINERAL RESEARCH. 14:S140-S140. Author weblink.
  • Stevens DA; Williams GR. (25 May 1999). Hormone regulation of chondrocyte differentiation and endochondral bone formation. Mol Cell Endocrinol. 151:195-204.
  • Bassett JH; O'Halloran DJ; Williams GR; Beardwell CG; Shalet SM; Thakker RV. (Jan 1999). Novel DAX1 mutations in X-linked adrenal hypoplasia congenita and hypogonadotrophic hypogonadism. Clin Endocrinol (Oxf). 50:69-75.
  • Williams GR; Robson H; Shalet SM. (Jun 1998). Thyroid hormone actions on cartilage and bone: interactions with other hormones at the epiphyseal plate and effects on linear growth. J Endocrinol. 157:391-403.
  • McTernan PG; Sheppard MC; Williams GR. (Jan 1998). Hormone-induced changes in nuclear receptor stoichiometry in HL60 cells correlate with induction of monocyte or neutrophil differentiation. J Endocrinol. 156:135-148.
  • Bland R; Sammons RL; Sheppard MC; Williams GR. (Jul 1997). Thyroid hormone, vitamin D and retinoid receptor expression and signalling in primary cultures of rat osteoblastic and immortalised osteosarcoma cells. J Endocrinol. 154:63-74.
  • Kane KF; Walker EA; Langman MJS; Williams GR. (1 Apr 1997). Differential activity of vitamin D-3 analogs in a human colon cancer cell line results from altered metabolism. GASTROENTEROLOGY. 112:A1160-A1160. Author weblink.
  • Williams GR. (1997). Bone structure and metabolism. Medicine. 25:60-64.
  • McTernan PG; Sheppard MC; Williams GR. (1 Aug 1996). Changes in vitamin D and retinoid receptor stoichiometry promote differentiation of HL60 cells to monocytes or neutrophils. JOURNAL OF BONE AND MINERAL RESEARCH. 11:M528-M528. Author weblink.
  • Kane KF; Langman MJS; Williams GR. (1 Feb 1996). Antiproliferative responses of two human colon cancer cell lines to vitamin D-3 are differentially modified by 9-cis-retinoic acid. CANCER RESEARCH. 56:623-632. Author weblink.
  • Williams GR; Bland R; Sheppard MC. (Oct 1995). Retinoids modify regulation of endogenous gene expression by vitamin D3 and thyroid hormone in three osteosarcoma cell lines. Endocrinology. 136:4304-4314.
  • WILLIAMS GR; BLAND R; SHEPPARD MC. (1 Aug 1995). VITAMIN-D3 REGULATION OF OSTEOPONTIN EXPRESSION IN OSTEOBLASTS IS MODIFIED BY RETINOIDS, THYROID-HORMONE, CELL CONFLUENCE AND STAGE OF CELL-DIFFERENTIATION. JOURNAL OF BONE AND MINERAL RESEARCH. 10:S491-S491. Author weblink.
  • KANE KF; LANGMAN MJS; WILLIAMS GR. (1 Apr 1995). ANTIPROLIFERATIVE RESPONSES OF 2 HUMAN COLORECTAL-CANCER CELL-LINES TO VITAMIN-D, ARE DIFFERENTIALLY MODIFIED BY 9-CIS RETINOIC ACID. GASTROENTEROLOGY. 108:A487-A487. Author weblink DOI.
  • KANE KF; MICHELL NP; LANGMAN MJS; WILLIAMS GR. (1 Apr 1995). FUNCTIONAL VITAMIN-D(3) RECEPTORS ARE PRESENT IN HUMAN COLORECTAL NEOPLASMS. GASTROENTEROLOGY. 108:A487-A487. Author weblink DOI.
  • BUNCE CM; WALLINGTON LA; HARRISON P; WILLIAMS GR; BROWN G. (1 Mar 1995). TREATMENT OF HL-60 CELLS WITH VARIOUS COMBINATIONS OF RETINOIDS AND 1-ALPHA,25 DIHYDROXYVITAMIN D-3 RESULTS IN DIFFERENTIATION TOWARDS NEUTROPHILS OR MONOCYTES OR A FAILURE TO DIFFERENTIATE AND APOPTOSIS. LEUKEMIA. 9:410-418. Author weblink.
  • KANE KF; LANGMAN MJS; WILLIAMS GR. (1 Feb 1995). 1,25-DIHYDROXYVITAMIN-D-3 AND RETINOID-X RECEPTOR EXPRESSION IN HUMAN COLORECTAL NEOPLASMS. GUT. 36:255-258. Author weblink DOI.
  • Williams GR; Bland R; Sheppard MC. (Dec 1994). Characterization of thyroid hormone (T3) receptors in three osteosarcoma cell lines of distinct osteoblast phenotype: interactions among T3, vitamin D3, and retinoid signaling. Endocrinology. 135:2375-2385.
  • WILLIAMS GR. (4 Aug 1994). HORMONES - SOLVING THE SPECIFICITY PUZZLE. NATURE. 370:330-331. Author weblink DOI.
  • BROWN G; BUNCE CM; ROWLANDS DC; WILLIAMS GR. (1 May 1994). ALL-TRANS-RETINOIC ACID AND 1-ALPHA,25-DIHYDROXYVITAMIN D-3 COOPERATE TO PROMOTE DIFFERENTIATION OF THE HUMAN PROMYELOID LEUKEMIA-CELL LINE HL-60 TO MONOCYTES. LEUKEMIA. 8:806-815. Author weblink.
  • Williams GR; Franklyn JA. (Apr 1994). Physiology of the steroid-thyroid hormone nuclear receptor superfamily. Baillieres Clin Endocrinol Metab. 8:241-266.
  • Williams GR; Zavacki AM; Harney JW; Brent GA. (Apr 1994). Thyroid hormone receptor binds with unique properties to response elements that contain hexamer domains in an inverted palindrome arrangement. Endocrinology. 134:1888-1896.
  • KANE KF; LANGMAN MJS; WILLIAMS GR. (1 Apr 1994). VITAMIN-D AND RETINOID X RECEPTOR GENE-EXPRESSION IN HUMAN COLONIC MUCOSA AND TUMORS PROVIDES A RATIONAL BASIS FOR THERAPY WITH 1,25-(OH)2 VITAMIN-D(3) ANALOGS. GASTROENTEROLOGY. 106:A400-A400. Author weblink.
  • WILLIAMS GR; BLAND R; SHEPPARD MC. (1 Aug 1993). THYROID-HORMONE REGULATION OF GENE-EXPRESSION IN CELLS OF DISTINCT OSTEOBLAST PHENOTYPE. JOURNAL OF BONE AND MINERAL RESEARCH. 8:S295-S295. Author weblink.
  • WILLIAMS GR; BRENT GA. (1 Nov 1992). SPECIFICITY OF NUCLEAR HORMONE RECEPTOR ACTION - WHO CONDUCTS THE ORCHESTRA. JOURNAL OF ENDOCRINOLOGY. 135:191-194. Author weblink DOI.
  • Williams GR; Harney JW; Moore DD; Larsen PR; Brent GA. (Oct 1992). Differential capacity of wild type promoter elements for binding and trans-activation by retinoic acid and thyroid hormone receptors. Mol Endocrinol. 6:1527-1537.
  • Brent GA; Williams GR; Harney JW; Forman BM; Samuels HH; Moore DD; Larsen PR. (Apr 1992). Capacity for cooperative binding of thyroid hormone (T3) receptor dimers defines wild type T3 response elements. Mol Endocrinol. 6:502-514.
  • Williams GR; Harney JW; Forman BM; Samuels HH; Brent GA. (15 Oct 1991). Oligomeric binding of T3 receptor is required for maximal T3 response. J Biol Chem. 266:19636-19644.
  • Williams GR; Franklyn JA; Sheppard MC. (Sep 1991). Thyroid hormone and glucocorticoid regulation of receptor and target gene mRNAs in pituitary GH3 cells. Mol Cell Endocrinol. 80:127-138.
  • Brent GA; Williams GR; Harney JW; Forman BM; Samuels HH; Moore DD; Larsen PR. (Apr 1991). Effects of varying the position of thyroid hormone response elements within the rat growth hormone promoter: implications for positive and negative regulation by 3,5,3'-triiodothyronine. Mol Endocrinol. 5:542-548.
  • Williams GR; Franklyn JA; Neuberger JM; Sheppard MC. (23 Dec 1989). Thyroid hormone receptor expression in the "sick euthyroid" syndrome. Lancet. 2:1477-1481.
  • Chapman AJ; Williams GR; London DR. (6 Jul 1985). Pituitary apoplexy after combined test of anterior pituitary function. BMJ: British Medical Journal. 291:26.
  • WILLIAMS GR; NICHOLSON JK. (1 Jan 1983). THE HISTOLOGY AND FINE-STRUCTURE OF THE URETER OF THE EUROPEAN STARLING (STURNUS-VULGARIS). JOURNAL OF ANATOMY. 136:585-594. Author weblink.

Books

  • Williams GR. Thyroid hormone regulation of gene expression. . R G Landes Co (Jul 1994).

Chapters in books

  • Cheung MS; Gogakos A; Bassett JHD; Williams GR. Thyroid Disease and Osteoporosis. In Oxford Textbook of Endocrinology and Diabetes. 712-720. Wass J (ed); Stewart P (ed). Oxford University Press, USA (1 Aug 2011).
  • Martin N; Williams GR. Vitamin D deficiency. In Horizons in Medicine. 17:193-201. COR RCOPOL (ed). (Dec 2005).
  • Williams GR. Thyroid hormone action on the skeleton and growth. In Encyclopedia of hormones & Related Cell Regulators. 3:466-472. Henry HL (ed); Norman AW (ed). Academic Pr (30 May 2003).
  • Williams GR. Thyroid disease and osteoporosis. In Oxford textbook of endocrinology and diabetes. 677-683. (2002).
  • Williams GR. Thyroid hormone and bone. In Harrison's Principles of Internal Medicine, 15th Edition Textbook & Self-Assessment and Board Review. www.harrisonsonline.com. Braunwald E (ed); Fauci AS (ed); Kasper DL (ed); Stone RM (ed); Hauser SL (ed); Longo DL (ed); Jameson JL (ed). McGraw-Hill (1 Dec 2001).
  • Williams GR. RACE-PCR (Rapid amplification of cDNA ends-polymerase chain reaction). In Wiley Encyclopedia of Molecular Medicine. 2713-2717. Creighton TE (ed). Wiley-Interscience (1 Nov 2001).
  • Williams GR. Calcifediol. In Therapeutic drugs. C8-C12. Dollery CT (ed). (1999).
  • Williams GR. Calcitonin. In Therapeutic drugs. C14-C18. Dollery CT (ed). (1999).
  • Williams GR. Calcitriol. In Therapeutic drugs. C19-C24. Dollery CT (ed). (1999).
  • Williams GR. Vitamin D and its major metabolites. In Therapeutic drugs. V41-V45. Dollery CT (ed). (1999).
  • Williams GR. Steroid hormone receptors and hormone resistance syndromes. In Molecular genetics of endocrine disorders. 153-182. Thakker RV (ed). A Hodder Arnold Publication (1997).
  • Williams GR; Brent GA. Thyroid hormone response elements. In Molecular Endocrinology. 217-239. Weintraub BD (ed). Raven Pr (1995).

Conferences

  • Bassett JHD; Lu Y; Bernstein ND; Archanco M; Galliford TM; Ghaffar A; Yu M; Hernandez R; et alO'Shea PJ; Williams GR. Biological Effects of Thyroid Hormone on Bone. 13th International Congress of Endocrinology, 8 Nov 2008 - 12 Nov 2008. 175-180. MEDIMOND S R L (1 Jan 2008). Author weblink.
  • Bassett JHD; O'Shea PJ; Nordstrom K; Vennstrom B; Williams GR. Disruption of intramembranous and endochondral bone development in TR alpha 2 null mice. 2nd Joint Meeting of the European-Calcified-Tissue-Society/International-Bone-and-Mineral-Society, 25 Jun 2005 - 29 Jun 2005. 36:S225-S225. ELSEVIER SCIENCE INC (1 Jun 2005). Author weblink.
  • Williams GR. Thyroid and bone. 2nd Joint Meeting of the European-Calcified-Tissue-Society/International-Bone-and-Mineral-Society, 25 Jun 2005 - 29 Jun 2005. 36:S111-S111. ELSEVIER SCIENCE INC (1 Jun 2005). Author weblink.
  • Williams GR. Thyroid hormone actions in bone and cartilage. Annual Meeting of the Bone-and-Tooth-Society, 9 Jul 2003 - 11 Jul 2003. 18:1357-1357. AMER SOC BONE & MINERAL RES (1 Jul 2003). Author weblink.
  • Dilworth FJ; Williams GR; Kissmeyer AM; Nielsen JL; Binderup E; Calverley MJ; Makin HLJ; Jones G. The vitamin D analog, KH1060, is rapidly degraded both in vivo and in vitro via several pathways: Principal metabolites generated retain significant biological activity. 18th Annual Meeting of the American-Society-for-Bone-and-Mineral-Research, 7 Sep 1996 - 11 Sep 1996. 138:5485-5496. ENDOCRINE SOC (1 Dec 1997). Author weblink DOI.
  • WILLIAMS GR; BLAND R; SHEPPARD MC. 1,25(OH)(2)-vitamin D3 (D3) interactions with 3,5,3'triiodothyronine (T3) signaling in 3 osteosarcoma cell lines. 9th Workshop on Vitamin D, 28 May 1994 - 2 Jun 1994. 288-289. WALTER DE GRUYTER (1 Jan 1994). Author weblink.
  • KANE KF; LANGMAN MJS; WILLIAMS GR. 1,25(OH)(2)-vitamin D-3 (D-3) signaling in HT-29 cells: Interactions with 9-cis retinoic acid (9-cis RA). 9th Workshop on Vitamin D, 28 May 1994 - 2 Jun 1994. 290-291. WALTER DE GRUYTER (1 Jan 1994). Author weblink.
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