Professor Hideaki Nagase

Publications


Journals

  • Durigova M; Nagase H; Mort JS; Roughley PJ. (1 Mar 2011). MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein. MATRIX BIOLOGY. 30:145-153. Author weblink DOI.
  • Tochowicz A; Goettig P; Evans R; Visse R; Shitomi Y; Palmisano R; Ito N; Richter K; et alMaskos K; Franke D; Svergun D; Nagase H; Bode W; Itoh Y. (4 Mar 2011). The Dimer Interface of the Membrane Type 1 Matrix Metalloproteinase Hemopexin Domain CRYSTAL STRUCTURE AND BIOLOGICAL FUNCTIONS. JOURNAL OF BIOLOGICAL CHEMISTRY. 286:7587-7600. Author weblink DOI.
  • Durigova M; Troeberg L; Nagase H; Roughley PJ; Mort JS. (1 Jan 2011). INVOLVEMENT OF ADAMTS5 AND HYALURONIDASE IN AGGRECAN DEGRADATION AND RELEASE FROM OSM-STIMULATED CARTILAGE. EUROPEAN CELLS & MATERIALS. 21:31-45.
  • Caglic D; Globisch A; Kindermann M; Lim N-H; Jeske V; Juretschke H-P; Bartnik E; Weithmann KU; et alNagase H; Turk B; Wendt KU. (1 Feb 2011). Functional in vivo imaging of cysteine cathepsin activity in murine model of inflammation. BIOORGANIC & MEDICINAL CHEMISTRY. 19:1055-1061. DOI.
  • Murphy G; Nagase H. (Jan 2011). Localizing matrix metalloproteinase activities in the pericellular environment. FEBS J. 278:2-15. DOI.
  • Maingot L; Leroux F; Landry V; Dumont J; Nagase H; Villoutreix B; Sperandio O; Deprez-Poulain R; et alDeprez B. (1 Nov 2010). New non-hydroxamic ADAMTS-5 inhibitors based on the 1,2,4-triazole-3-thiol scaffold. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 20:6213-6216. DOI.
  • Lim NH; Kashiwagi M; Visse R; Jones J; Enghild JJ; Brew K; Nagase H. (1 Oct 2010). Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications. Biochem J. 431:113-122. DOI Open Access copy.
  • Kveiborg M; Jacobsen J; Lee M-H; Nagase H; Wewer UM; Murphy G. (15 Aug 2010). Selective inhibition of ADAM12 catalytic activity through engineering of tissue inhibitor of metalloproteinase 2 (TIMP-2). BIOCHEMICAL JOURNAL. 430:79-86. DOI.
  • Han S; Makareeva E; Kuznetsova NV; DeRidder AM; Sutter MB; Losert W; Phillips CL; Visse R; et alNagase H; Leikin S. (16 Jul 2010). Molecular Mechanism of Type I Collagen Homotrimer Resistance to Mammalian Collagenases. JOURNAL OF BIOLOGICAL CHEMISTRY. 285:22276-22281. DOI.
  • Pozgan U; Caglic D; Rozman B; Nagase H; Turk V; Turk B. (1 May 2010). Expression and activity profiling of selected cysteine cathepsins and matrix metalloproteinases in synovial fluids from patients with rheumatoid arthritis and osteoarthritis. BIOLOGICAL CHEMISTRY. 391:571-579. Author weblink DOI.
  • Bekhouche M; Kronenberg D; Vadon-Le Goff S; Bijakowski C; Lim NH; Font B; Kessler E; Colige A; et alNagase H; Murphy G; Hulmes DJS; Moali C. (21 May 2010). Role of the Netrin-like Domain of Procollagen C-Proteinase Enhancer-1 in the Control of Metalloproteinase Activity. JOURNAL OF BIOLOGICAL CHEMISTRY. 285:15950-15959. Author weblink DOI.
  • Makareeva E; Han S; Vera JC; Sackett DL; Holmbeck K; Phillips CL; Visse R; Nagase H; et alLeikin S. (1 Jun 2010). Carcinomas contain a matrix metalloproteinase-resistant isoform of type I collagen exerting selective support to invasion. Cancer Res. 70:4366-4374. DOI.
  • Brew K; Nagase H. (1 Jan 2010). The tissue inhibitors of metalloproteinases (TIMPs): An ancient family with structural and functional diversity. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. 1803:55-71. DOI.
  • Nuti E; Casalini F; Avramova SI; Santamaria S; Cercignani G; Marinelli L; La Pietra V; Novellino E; et alOrlandini E; Nencetti S; Tuccinardi T; Martinelli A; Lim N-H; Visse R; Nagase H; Rossello A. (13 Aug 2009). N-O-Isopropyl Sulfonamido-Based Hydroxamates: Design, Synthesis and Biological Evaluation of Selective Matrix Metalloproteinase-13 Inhibitors as Potential Therapeutic Agents for Osteoarthritis. JOURNAL OF MEDICINAL CHEMISTRY. 52:4757-4773. Author weblink DOI.
  • Troeberg L; Fushimi K; Scilabra SD; Nakamura H; Dive V; Thøgersen IB; Enghild JJ; Nagase H. (Oct 2009). The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3. Matrix Biol. 28:463-469. DOI.
  • Dabert-Gay A-S; Czarny B; Lajeunesse E; Thai R; Nagase H; Dive V. (1 Feb 2009). Covalent Modification of Matrix Metalloproteinases by a Photoaffinity Probe: Influence of Nucleophilicity and Flexibility of the Residue in Position 241. BIOCONJUGATE CHEMISTRY. 20:367-375. Author weblink DOI.
  • Miller MC; Manning HB; Jain A; Troeberg L; Dudhia J; Essex D; Sandison A; Seiki M; et alNanchahal J; Nagase H; Itoh Y. (Mar 2009). Membrane type 1 matrix metalloproteinase is a crucial promoter of synovial invasion in human rheumatoid arthritis. Arthritis Rheum. 60:686-697. DOI.
  • Murphy G; Nagase H. (1 Oct 2008). Progress in matrix metalloproteinase research. MOLECULAR ASPECTS OF MEDICINE. 29:290-308. Author weblink DOI.
  • Durigova M; Soucy P; Fushimi K; Nagase H; Mort JS; Roughley PJ. (1 Oct 2008). Characterization of an ADAMTS-5-mediated cleavage site in aggrecan in OSM-stimulated bovine cartilage. OSTEOARTHRITIS AND CARTILAGE. 16:1245-1252. Author weblink DOI.
  • Troeberg L; Fushimi K; Khokha R; Emonard H; Ghosh P; Nagase H. (1 Oct 2008). Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases. FASEB JOURNAL. 22:3515-3524. Author weblink DOI.
  • Nagase H; Fushimi K. (2008). Elucidating the function of non catalytic domains of collagenases and aggrecanases. Connect Tissue Res. 49:169-174. DOI.
  • Itoh Y; Ito N; Nagase H; Seiki M. (9 May 2008). The second dimer interface of MT1-MMP, the transmembrane domain, is essential for ProMMP-2 activation on the cell surface. JOURNAL OF BIOLOGICAL CHEMISTRY. 283:13053-13062. Author weblink DOI.
  • Nagase H. (Aug 2001). Metalloproteases. Curr Protoc Protein Sci. Chapter 21:Unit-21.4. DOI.
  • Troeberg L; Nagase H. (Nov 2004). Zymography of metalloproteinases. Curr Protoc Protein Sci. Chapter 21:Unit-21.15. DOI.
  • Troeberg L; Nagase H. (Nov 2004). Monitoring metalloproteinase activity using synthetic fluorogenic substrates. Curr Protoc Protein Sci. Chapter 21:Unit-21.16. DOI.
  • Fushimi K; Troeberg L; Nakamura H; Lim NH; Nagase H. (14 Mar 2008). Functional differences of the catalytic and non-catalytic domains in human ADAMTS-4 and ADAMTS-5 in aggrecanolytic activity. JOURNAL OF BIOLOGICAL CHEMISTRY. 283:6706-6716. Author weblink DOI.
  • Murphy G; Nagase H. (1 Mar 2008). Reappraising metalloproteinases in rheumatoid arthritis and osteoarthritis: destruction or repair?. NATURE CLINICAL PRACTICE RHEUMATOLOGY. 4:128-135. Author weblink DOI.
  • Lauer-Fields JL; Spicer TP; Chase PS; Cudic M; Burstein GD; Nagase H; Hodder P; Fields GB. (1 Feb 2008). Screening of potential a, disintegrin and metalloproteinase with thrombospondin motifs-4 inhibitors using a collagen model fluorescence resonance energy transfer substrate. ANALYTICAL BIOCHEMISTRY. 373:43-51. Author weblink DOI.
  • Jacobsen J; Visse R; Sørensen HP; Enghild JJ; Brew K; Wewer UM; Nagase H. (15 Jan 2008). Catalytic properties of ADAM12 and its domain deletion mutants. Biochemistry. 47:537-547. DOI.
  • Ries C; Pitsch T; Mentele R; Zahlert S; Egea V; Nagase H; Jochum M. (1 Aug 2007). Identification of a novel 82 kDa proMMP-9 species associated with the surface of leukaemic cells: (auto-)catalytic activation and resistance to inhibition by TIMP-1. BIOCHEMICAL JOURNAL. 405:547-558. Author weblink DOI.
  • Kopitz C; Gerg M; Bandapalli OR; Ister D; Pennington CJ; Hauser S; Flechsig C; Krell H-W; et alAntoloviC D; Brew K; Nagase H; Stangl M; Von Weyhern CWH; Bruecher BLDM; Brand K; Coussens LM; Edwards DR; Krueger A. (15 Sep 2007). Tissue inhibitor of metalloproteinases-1 promotes liver metastasis by induction of hepatocyte growth factor signaling. CANCER RESEARCH. 67:8615-8623. Author weblink DOI.
  • Gendron C; Kashiwagi M; Lim NH; Enghild JJ; Thogersen IB; Hughes C; Caterson B; Nagase H. (22 Jun 2007). Proteolytic activities of human ADAMTS-5 - Comparative studies with ADAMTS-4. JOURNAL OF BIOLOGICAL CHEMISTRY. 282:18294-18306. Author weblink DOI.
  • Saklatvala J; Dean J; Clark A. (2003). Control of the expression of inflammatory response genes. BIOCHEM SOC SYMP. 70:95-106.
  • Nagase H. (2001). Aggrecanases in cartliage matrix breakdown. Connect Tissue. 33:339-343.
  • Emonard H; Bellon G; Troeberg L; Berton A; Robinet A; Henriet P; Marbaix E; Kirkegaard K; et alPatthy L; Eeckhout Y; Nagase H; Hornebeck W; Courtoy PJ. (24 Dec 2004). Low density lipoprotein receptor-related protein mediates endocytic clearance of Pro-MMP-2 center dot TIMP-2 complex through a thrombospondin-independent mechanism. JOURNAL OF BIOLOGICAL CHEMISTRY. 279:54944-54951. Author weblink DOI.
  • Minond D; Lauer-Fields JL; Cudic M; Overall CM; Pei D; Brew K; Visse R; Nagase H; et alFields GB. (15 Dec 2006). The roles of substrate thermal stability and P-2 and P-1 ' subsite identity on matrix metalloproteinase triple-helical peptidase activity and collagen specificity. JOURNAL OF BIOLOGICAL CHEMISTRY. 281:38302-38313. Author weblink DOI.
  • Lauer-Fields JL; Minond D; Sritharan T; Kashiwagi M; Nagase H; Fields GB. (5 Jan 2007). Substrate conformation modulates aggrecanase (ADAMTS-4) affinity and sequence specificity. Suggestion of a common topological specificity for functionally diverse proteases. J Biol Chem. 282:142-150. DOI.
  • Itoh Y; Ito N; Nagase H; Evans RD; Bird SA; Seiki M. (Dec 2006). Cell surface collagenolysis requires homodimerization of the membrane-bound collagenase MT1-MMP. Mol Biol Cell. 17:5390-5399. DOI.
  • Wang W-M; Ge G; Lim NH; Nagase H; Greenspan DS. (15 Sep 2006). TIMP-3 inhibits the procollagen N-proteinase ADAMTS-2. BIOCHEMICAL JOURNAL. 398:515-519. Author weblink DOI.
  • Iyer S; Visse R; Nagase H; Acharya KR. (8 Sep 2006). Crystal structure of an active form of human MMP-1. JOURNAL OF MOLECULAR BIOLOGY. 362:78-88. Author weblink DOI.
  • Pinto AFM; Terra RMS; Guimaraes JA; Kashiwagi M; Nagase H; Serrano SMT; Fox JW. (1 Sep 2006). Structural features of the reprolysin atrolysin C and tissue inhibitors of metalloproteinases (TIMPs) interaction. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 347:641-648. Author weblink DOI.
  • English JL; Kassiri Z; Koskivirta I; Atkinson SJ; Di Grappa M; Soloway PD; Nagase H; Vuorio E; et alMurphy G; Khokha R. (14 Apr 2006). Individual Timp deficiencies differentially impact pro-MMP-2 activation. JOURNAL OF BIOLOGICAL CHEMISTRY. 281:10337-10346. Author weblink DOI.
  • Brew K; Dinakarpandian D; Nagase H. (7 Mar 2000). Tissue inhibitors of metalloproteinases: evolution, structure and function. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY. 1477:267-283. Author weblink DOI.
  • Nagase H; Brew K. Saklatvala J (ed); Nagase H (ed); Salvesen G (ed). (1 Jan 2003). DesigningTIMP (tissue inhibitor of metalloproteinases variants that are selective metalloproteinase inhibitors. PROTEASES AND THE REGULATION OF BIOLOGICAL PROCESSES. 70:201-212. Author weblink.
  • Anilkumar N; Uekita T; Couchman JR; Nagase H; Seiki M; Itoh Y. (1 Jun 2005). Palmitoylation at Cys(574) is essential for MT1-MMP to promote cell migration. FASEB JOURNAL. 19:1326-+. Author weblink DOI.
  • Ogata Y; Matono K; Nakajima M; Sasatomi T; Mizobe T; Nagase H; Shirouzu K. (1 Jan 2006). Efficacy of the MMP inhibitor MMI270 against lung metastasis following removal of orthotopically transplanted human colon cancer in rat. INTERNATIONAL JOURNAL OF CANCER. 118:215-221. Author weblink DOI.
  • Nagase H; Visse R; Murphy G. (15 Feb 2006). Structure and function of matrix metalloproteinases and TIMPs. Cardiovasc Res. 69:562-573. DOI.
  • Wei S; Kashiwagi M; Kota S; Xie Z; Nagase H; Brew K. (23 Sep 2005). Reactive site mutations in tissue inhibitor of metalloproteinase-3 disrupt inhibition of matrix metalloproteinases but not tumor necrosis factor-alpha-converting enzyme. J Biol Chem. 280:32877-32882. DOI.
  • Bai S; Thummel R; Godwin AR; Nagase H; Itoh Y; Li L; Evans R; McDermott J; et alSeiki M; Sarras MP. (Jun 2005). Matrix metalloproteinase expression and function during fin regeneration in zebrafish: analysis of MT1-MMP, MMP2 and TIMP2. Matrix Biol. 24:247-260. DOI.
  • Jozic D; Bourenkov G; Lim NH; Visse R; Nagase H; Bode W; Maskos K. (11 Mar 2005). X-ray structure of human proMMP-1: new insights into procollagenase activation and collagen binding. J Biol Chem. 280:9578-9585. DOI.
  • Emonard H; Bellon G; Troeberg L; Berton A; Robinet A; Henriet P; Marbaix E; Kirkegaard K; et alPatthy L; Eeckhout Y; Nagase H; Hornebeck W; Courtoy PJ. (24 Dec 2004). Low density lipoprotein receptor-related protein mediates endocytic clearance of pro-MMP-2.TIMP-2 complex through a thrombospondin-independent mechanism. J Biol Chem. 279:54944-54951. DOI.
  • Lauer-Fields JL; Nagase H; Fields GB. (Dec 2004). Development of a solid-phase assay for analysis of matrix metalloproteinase activity. J Biomol Tech. 15:305-316.
  • Minond D; Lauer-Fields JL; Nagase H; Fields GB. (14 Sep 2004). Matrix metalloproteinase triple-helical peptidase activities are differentially regulated by substrate stability. Biochemistry. 43:11474-11481. DOI.
  • Chung L; Dinakarpandian D; Yoshida N; Lauer-Fields JL; Fields GB; Visse R; Nagase H. (4 Aug 2004). Collagenase unwinds triple-helical collagen prior to peptide bond hydrolysis. EMBO J. 23:3020-3030. DOI.
  • Sultan S; Gosling M; Nagase H; Powell JT. (23 Apr 2004). Shear stress-induced shedding of soluble intercellular adhesion molecule-1 from saphenous vein endothelium. FEBS Lett. 564:161-165. DOI.
  • Kashiwagi M; Enghild JJ; Gendron C; Hughes C; Caterson B; Itoh Y; Nagase H. (12 Mar 2004). Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing. J Biol Chem. 279:10109-10119. DOI.
  • Zhao H; Bernardo MM; Osenkowski P; Sohail A; Pei D; Nagase H; Kashiwagi M; Soloway PD; et alDeClerck YA; Fridman R. (5 Mar 2004). Differential inhibition of membrane type 3 (MT3)-matrix metalloproteinase (MMP) and MT1-MMP by tissue inhibitor of metalloproteinase (TIMP)-2 and TIMP-3 rgulates pro-MMP-2 activation. J Biol Chem. 279:8592-8601. DOI.
  • Conant K; St Hillaire C; Nagase H; Visse R; Gary D; Haughey N; Anderson C; Turchan J; et alNath A. (27 Feb 2004). Matrix metalloproteinase 1 interacts with neuronal integrins and stimulates dephosphorylation of Akt. J Biol Chem. 279:8056-8062. DOI.
  • Fowlkes JL; Serra DM; Bunn RC; Thrailkill KM; Enghild JJ; Nagase H. (Feb 2004). Regulation of insulin-like growth factor (IGF)-I action by matrix metalloproteinase-3 involves selective disruption of IGF-I/IGF-binding protein-3 complexes. Endocrinology. 145:620-626. DOI.
  • Saklatvala J; Nagase H. (2004). Report on the Molecular Approaches to Osteoarthritis Symposium, Imperial College London, UK, 18-20 April 2004. Arthritis Res Ther. 6:203-207. DOI.
  • Gendron C; Kashiwagi M; Hughes C; Caterson B; Nagase H. (18 Dec 2003). TIMP-3 inhibits aggrecanase-mediated glycosaminoglycan release from cartilage explants stimulated by catabolic factors. FEBS Lett. 555:431-436.
  • Liu J; Xiong W; Baca-Regen L; Nagase H; Baxter BT. (Dec 2003). Mechanism of inhibition of matrix metalloproteinase-2 expression by doxycycline in human aortic smooth muscle cells. J Vasc Surg. 38:1376-1383. DOI.
  • Lauer-Fields JL; Kele P; Sui G; Nagase H; Leblanc RM; Fields GB. (1 Oct 2003). Analysis of matrix metalloproteinase triple-helical peptidase activity with substrates incorporating fluorogenic L- or D-amino acids. Anal Biochem. 321:105-115.
  • Zhang J; Bai S; Zhang X; Nagase H; Sarras MP. (Sep 2003). The expression of gelatinase A (MMP-2) is required for normal development of zebrafish embryos. Dev Genes Evol. 213:456-463. DOI.
  • Zhang J; Bai S; Tanase C; Nagase H; Sarras MP. (Aug 2003). The expression of tissue inhibitor of metalloproteinase 2 (TIMP-2) is required for normal development of zebrafish embryos. Dev Genes Evol. 213:382-389. DOI.
  • Lauer-Fields JL; Sritharan T; Stack MS; Nagase H; Fields GB. (16 May 2003). Selective hydrolysis of triple-helical substrates by matrix metalloproteinase-2 and -9. J Biol Chem. 278:18140-18145. DOI.
  • Visse R; Nagase H. (2 May 2003). Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Circ Res. 92:827-839. DOI.
  • Zhang J; Bai S; Zhang X; Nagase H; Sarras MP. (May 2003). The expression of novel membrane-type matrix metalloproteinase isoforms is required for normal development of zebrafish embryos. Matrix Biol. 22:279-293.
  • Ahonen M; Poukkula M; Baker AH; Kashiwagi M; Nagase H; Eriksson JE; Kähäri VM. (10 Apr 2003). Tissue inhibitor of metalloproteinases-3 induces apoptosis in melanoma cells by stabilization of death receptors. Oncogene. 22:2121-2134. DOI.
  • Wei S; Chen Y; Chung L; Nagase H; Brew K. (14 Mar 2003). Protein engineering of the tissue inhibitor of metalloproteinase 1 (TIMP-1) inhibitory domain. In search of selective matrix metalloproteinase inhibitors. J Biol Chem. 278:9831-9834. DOI.
  • Nagase H; Kashiwagi M. (2003). Aggrecanases and cartilage matrix degradation. Arthritis Res Ther. 5:94-103.
  • Troeberg L; Tanaka M; Wait R; Shi YE; Brew K; Nagase H. (17 Dec 2002). E. coli expression of TIMP-4 and comparative kinetic studies with TIMP-1 and TIMP-2: insights into the interactions of TIMPs and matrix metalloproteinase 2 (gelatinase A). Biochemistry. 41:15025-15035.
  • Matsushita N; Kashiwagi M; Wait R; Nagayoshi R; Nakamura M; Matsuda T; Hogger P; Guyre PM; et alNagase H; Matsuyama T. (Oct 2002). Elevated levels of soluble CD163 in sera and fluids from rheumatoid arthritis patients and inhibition of the shedding of CD163 by TIMP-3. Clin Exp Immunol. 130:156-161.
  • Murphy FR; Issa R; Zhou X; Ratnarajah S; Nagase H; Arthur MJ; Benyon C; Iredale JP. (29 Mar 2002). Inhibition of apoptosis of activated hepatic stellate cells by tissue inhibitor of metalloproteinase-1 is mediated via effects on matrix metalloproteinase inhibition: implications for reversibility of liver fibrosis. J Biol Chem. 277:11069-11076. DOI.
  • Kang T; Nagase H; Pei D. (1 Feb 2002). Activation of membrane-type matrix metalloproteinase 3 zymogen by the proprotein convertase furin in the trans-Golgi network. Cancer Res. 62:675-681.
  • Nagase H; Brew K. (2002). Engineering of tissue inhibitor of metalloproteinases mutants as potential therapeutics. Arthritis Res. 4 Suppl 3:S51-S61.
  • Itoh Y; Nagase H. (2002). Matrix metalloproteinases in cancer. Essays Biochem. 38:21-36.
  • Stricker TP; Dumin JA; Dickeson SK; Chung L; Nagase H; Parks WC; Santoro SA. (3 Aug 2001). Structural analysis of the alpha(2) integrin I domain/procollagenase-1 (matrix metalloproteinase-1) interaction. J Biol Chem. 276:29375-29381. DOI.
  • Nollendorfs A; Greiner TC; Nagase H; Baxter BT. (Aug 2001). The expression and localization of membrane type-1 matrix metalloproteinase in human abdominal aortic aneurysms. J Vasc Surg. 34:316-322. DOI.
  • Lauer-Fields JL; Broder T; Sritharan T; Chung L; Nagase H; Fields GB. (15 May 2001). Kinetic analysis of matrix metalloproteinase activity using fluorogenic triple-helical substrates. Biochemistry. 40:5795-5803.
  • Kashiwagi M; Tortorella M; Nagase H; Brew K. (20 Apr 2001). TIMP-3 is a potent inhibitor of aggrecanase 1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5). J Biol Chem. 276:12501-12504. DOI.
  • Tamura T; Kosaka N; Ishiwa J; Sato T; Nagase H; Ito A. (Apr 2001). Rhein, an active metabolite of diacerein, down-regulates the production of pro-matrix metalloproteinases-1, -3, -9 and -13 and up-regulates the production of tissue inhibitor of metalloproteinase-1 in cultured rabbit articular chondrocytes. Osteoarthritis Cartilage. 9:257-263. DOI.
  • Yamauchi K; Ogata Y; Nagase H; Shirouzu K. (2001). Inhibition of liver metastasis from orthotopically implanted colon cancer in nude mice by transfection of the TIMP-1 gene into KM12SM cells. Surg Today. 31:791-798.
  • Chung L; Shimokawa K; Dinakarpandian D; Grams F; Fields GB; Nagase H. (22 Sep 2000). Identification of the (183)RWTNNFREY(191) region as a critical segment of matrix metalloproteinase 1 for the expression of collagenolytic activity. J Biol Chem. 275:29610-29617. DOI.
  • Lauer-Fields JL; Nagase H; Fields GB. (18 Aug 2000). Use of Edman degradation sequence analysis and matrix-assisted laser desorption/ionization mass spectrometry in designing substrates for matrix metalloproteinases. J Chromatogr A. 890:117-125.
  • Leontovich AA; Zhang J; Shimokawa K; Nagase H; Sarras MP. (Feb 2000). A novel hydra matrix metalloproteinase (HMMP) functions in extracellular matrix degradation, morphogenesis and the maintenance of differentiated cells in the foot process. Development. 127:907-920.

Chapters in books

  • Nagase H; Salvesen GS. Finding, purification and characterization of natural protease inhibitors. 2nd:131-147. (2001).
  • Salvesen GS; Nagase H. Inhibition of proteolytic enzymes. 2nd:105-130. (2001).
  • Nagase H. Metalloproteinases. 21-21. (2001).
  • Nagase H. Substrate specificity of MMPs. 39-66. (2001).

Conferences

  • Gardiner MD; Nagase H. Proteomic analysis of cartilage protein profiles in a mouse model of osteoarthritis. Autumn Meeting of the British-Society-for-Matrix-Biology, 6 Sep 2010 - 7 Sep 2010. 92:A34-A35. WILEY-BLACKWELL (1 Jun 2011). Author weblink.
  • Troeberg L; Mulloy B; Lee M-H; Murphy G; Nagase H. Calcium pentosan polysulfate increases affinity between aggrecanases (ADAMTS-4 and-5) and TIMP-3 by a conformational change. Spring Meeting of the British-Society-for-Matrix-Biology, 29 Mar 2010 - 30 Mar 2010. 91:A40-A40. WILEY-BLACKWELL (1 Dec 2010). Author weblink.
  • Tochowicz A; Goettig P; Visse R; Shitomi Y; Maskos K; Nagase H; Bode W; Itoh Y. Crystal structure of MT1-MMP hemopexin domain: identification of the dimer interface. Spring Meeting of the British-Society-for-Matrix-Biology, 29 Mar 2010 - 30 Mar 2010. 91:A39-A40. WILEY-BLACKWELL (1 Dec 2010). Author weblink.
  • Manka SW; Visse R; Nagase H. Triple-helical collagen unwinding relies on cooperative binding of the catalytic and hemopexin domains of collagenase. Spring Meeting of the British-Society-for-Matrix-Biology, 29 Mar 2010 - 30 Mar 2010. 91:A17-A17. WILEY-BLACKWELL (1 Dec 2010). Author weblink.
  • Makareeva E; Han S; Vera J; Sackett D; Holmbeck K; McBride DJ; Phillips CL; Schwarze U; et alPace JM; Byer PH; Visse R; Nagase H; Leikin S. Cancer cells secrete MMP-resistant isoform of type I collagen. 9th International Meeting on Cancer Induced Bone Disease, 28 Oct 2009 - 31 Oct 2009. 47:S297-S297. ELSEVIER SCIENCE INC (1 Jul 2010). DOI.
  • Santamaria S; Nuti E; Casalini F; Avramova S; Cercignani G; Orlandini E; Nencetti S; Lim NH; et alVisse R; Nagase H; Rossello A. Kinetic characterization of new selective collagenase 3 (MMP-13) inhibitors as potential therapeutic agents in osteoarthritis. 34th Congress of the Federation-of-European-Biochemical-Societies, 4 Jul 2009 - 9 Jul 2009. 276:341-341. WILEY-BLACKWELL PUBLISHING, INC (1 Jul 2009). Author weblink.
  • Sofat N; Troeberg L; Nagase H. The type III 8-10 repeats of fibronectin induce aggrecanase activity via alpha(5)beta(1) integrin and type III 13-14 repeats act via TLR 4 receptors. Annual General Meeting of the British-Society-for-Matrix-Biology, 7 Apr 2008 - 8 Apr 2008. 90:A129-A130. WILEY-BLACKWELL (1 Apr 2009). Author weblink.
  • Nagase H. Aggrecan breakdown in cartilage induced by proteolytic fragments of fibronectin: implications in osteoarthritis. Annual General Meeting of the British-Society-for-Matrix-Biology, 7 Apr 2008 - 8 Apr 2008. 90:A98-A99. WILEY-BLACKWELL PUBLISHING, INC (1 Apr 2009). Author weblink.
  • Miller M-C; Manning HB; Jain A; Troeberg L; Dudhia J; Essex D; Sandison A; Seiki M; et alNanchahal J; Nagase H; Itoh Y. MT1-MMP in human rheumatoid arthritis. Annual General Meeting of the British-Society-for-Matrix-Biology, 7 Apr 2008 - 8 Apr 2008. 90:A97-A97. WILEY-BLACKWELL PUBLISHING, INC (1 Apr 2009). Author weblink.
  • Troeberg L; Nagase H. Calcium pentosan polysulfate is a multi-functional aggrecanase inhibitor that enhances interaction with endogenous TIMP-3 in cartilage. Annual General Meeting of the British-Society-for-Matrix-Biology, 7 Apr 2008 - 8 Apr 2008. 90:A67-A67. WILEY-BLACKWELL PUBLISHING, INC (1 Feb 2009). Author weblink.
  • Owen K; Troeberg L; Parker A; Nagase H. Investigation of the endocytic pathway of ADAMTS-4. Annual General Meeting of the British-Society-for-Matrix-Biology, 7 Apr 2008 - 8 Apr 2008. 90:A64-A64. WILEY-BLACKWELL PUBLISHING, INC (1 Feb 2009). Author weblink.
  • Lim NH; Kashiwagi M; Wei S; Brew K; Nagase H. Characterisation of N-TIMP-3 mutants that selectively inhibit the ADAMTSs. Annual General Meeting of the British-Society-for-Matrix-Biology, 7 Apr 2008 - 8 Apr 2008. 90:A63-A63. WILEY-BLACKWELL PUBLISHING, INC (1 Feb 2009). Author weblink.
  • Nagase H. Aggrecanases and TIMP-3 in osteoarthritis: structure, function and in vivo challenges. Annual General Meeting of the British-Society-for-Matrix-Biology, 7 Apr 2008 - 8 Apr 2008. 90:A49-A49. WILEY-BLACKWELL PUBLISHING, INC (1 Feb 2009).
  • Han S; Makareeva E; Kuznetsova NV; DeRidder AM; Sutter MB; McBride DJ; Phillips CL; Schwartze U; et alPace JM; Byers PH; Visse R; Nagase H; Leikin S. Do Type I Collagen Homotrimers Contribute to Osteoporosis by Altering Bone Remodeling?. 30th Annual Meeting of the American-Society-for-Bone-and-Mineral-Research, 12 Sep 2008 - 16 Sep 2008. 23:S162-S162. AMER SOC BONE & MINERAL RES (1 Sep 2008). Author weblink.
  • Sofat N; Wait R; Nagase H. Fibronectin fragments induce aggrecan degradation in human cartilage and are increased in osteoarthritic cartilage. Annual Meeting of the British-Society-of-Rheumatology. 46:I14-I14. (Apr 2007).
  • Itoh Y; Ito N; Otake Y; Nagase H; Seiki M. Distinct roles of the hemopexin and the transmembrane domains as dimer interfaces of MT1-MMP on the cell surface. Joint British-Society-for-Matrix-Biology/Biochemical Society Focused Meeting, 2 Apr 2007 - 3 Apr 2007. 88:A94-A95. BLACKWELL PUBLISHING (1 Dec 2007). Author weblink.
  • Murphy F; Waung J; Patel N; Collins J; Brew K; Nagase H; Arthur MJP; Benyon RC; et alIredale JP. Balance of TIMP-1 and MMP-2 determines N-cadherin cleavage in hepatic stellate cell apoptosis. Annual meeting of the British-Society-of-Gastroenterology. 52:A2-A2. (Apr 2003).
  • Anilkumer N; Uekita T; Couchman J; Seiki M; Nagase H; Itoh Y. Palmitoylation of MT1-MMP at cysteine 574 in the cytoplasmic tail facilitates its internalisation and modulate cell migration. British Cancer Research Meeting 2004. 91:S72-S72. (Jul 2004).
  • Visse R; Bode W; Maskos K; Nagase H. Structural basis for collagenolytic activity of matrix metalloproteinase-1 (collagenase 1). Spring Meeting of the British-Society-for-Matrix-Biology. 86:A87-A88. (Dec 2005).
  • Kuznetsova NV; Makareeva E; Cabral WA; Visse R; Nagase H; Marini JC; Leikin S. Chain register shift in type I collagen alters MMP1 cleavage. Biennial Meeting of the American-Society-for-Matrix-Biology, 1 Nov 2006 - 4 Nov 2006. 25:S75-S75. ELSEVIER SCIENCE BV (1 Nov 2006). Author weblink DOI.
  • Nagase H; Visse R; Kashiwagi M; Gendron C; Itoh Y. Collagenases and aggrecanases: understanding the role of non-catalytic domains in cartilage matrix breakdown. 25th European Workshop for Rheumatology Research, 24 Feb 2005 - 27 Feb 2005. 7:S3-S3. BIOMED CENTRAL LTD (1 Feb 2005). Author weblink DOI.
  • Lauer-Fields J; Hammer R; Brew K; Nagase H; Fields GB. Selective inhibition of matrix metalloproteinase-2 and-9 by phosphinic acid pseudo-peptides containing triple-helical structure. Experimental Biology 2006 Meeting, 1 Apr 2006 - 5 Apr 2006. 20:A48-A48. FEDERATION AMER SOC EXP BIOL (6 Mar 2006). Author weblink.
  • Sofat N; Enghild J; Nagase H. Isolation of fibronectin fragments that induce aggrecan degradation in cartilage. Autumn Meeting of the British-Society-for-Matrix-Biology, 12 Sep 2005 - 13 Sep 2005. 87:A9-A10. BLACKWELL PUBLISHING (1 Feb 2006). Author weblink.
  • Nagase H; Gendron C; Kashiwagi M. TIMP-3 inhibits aggrecan breakdown in pig articular cartilage stimulated with IL-1. 3rd World Congress of the Global-Arthritis-Research-Network (GARN), 14 Sep 2003 - 17 Sep 2003. 5:S15-S16. BIOMED CENTRAL LTD (1 Jan 2003). Author weblink DOI.
  • Itoh Y; Ito N; Nagase H; Seiki M. Homophilic complex formation of MT1-matrix metalloproteinase is essential to express collagenolytic activity on the cell surface. Spring Meeting of the British-Society-for-Matrix-Biology, 2005. 86:A77-A77. BLACKWELL PUBLISHING (1 Dec 2005). Author weblink.
Share this on Delicious
Tweet this
Digg this
Stumble this
Share this on Facebook