Dr Isabelle Leclerc

Publications


Journals

  • Leclerc I; Rutter GA; Meur G; Noordeen N. (May 2012). Roles of Ca2+ ions in the control of ChREBP nuclear translocation. J Endocrinol. 213:115-122. DOI.
  • Noordeen NA; Meur G; Rutter GA; Leclerc I. (Mar 2012). Glucose-induced nuclear shuttling of ChREBP is mediated by sorcin and Ca(2+) ions in pancreatic β-cells. Diabetes. 61:574-585. DOI.
  • Noordeen N; Meur G; Rutter G; Leclerc I. (1 Mar 2011). Nuclear translocation of ChREBP depends of sorcini and calcium ions in the pancreatic beta cell. DIABETES & METABOLISM. 37:A1-A1. Author weblink.
  • Sun G; Reynolds R; Leclerc I; Rutter GA. (Mar 2011). RIP2-mediated LKB1 deletion causes axon degeneration in the spinal cord and hind-limb paralysis. Dis Model Mech. 4:193-202. DOI.
  • McDonald A; Fogarty S; Leclerc I; Hill EV; Hardie DG; Rutter GA. (Nov 2009). Control of insulin granule dynamics by AMPK dependent KLC1 phosphorylation. Islets. 1:198-209. DOI.
  • Yang CS; Lam CKL; Chari M; Cheung GWC; Kokorovic A; Gao S; Leclerc I; Rutter GA; et alLam TKT. (1 Oct 2010). Hypothalamic AMP-Activated Protein Kinase Regulates Glucose Production. DIABETES. 59:2435-2443. DOI.
  • Leclerc I; Sun G; Morris C; Fernandez-Millan E; Nyirenda M; Rutter GA. (Jan 2011). AMP-activated protein kinase regulates glucagon secretion from mouse pancreatic alpha cells. Diabetologia. 54:125-134. DOI.
  • da Silva Xavier G; Sun G; Qian Q; Rutter GA; Leclerc I. (12 Nov 2010). ChREBP regulates Pdx-1 and other glucose-sensitive genes in pancreatic β-cells. Biochem Biophys Res Commun. 402:252-257. DOI.
  • Yang CS; Lam CK; Chari M; Cheung GW; Kokorovic A; Gao S; Leclerc I; Rutter GA; et alLam TK. (Oct 2010). Hypothalamic AMP-activated protein kinase regulates glucose production. Diabetes. 59:2435-2443. DOI.
  • Sun G; Tarasov AI; McGinty JA; French PM; McDonald A; Leclerc I; Rutter GA. (Jun 2010). LKB1 deletion with the RIP2.Cre transgene modifies pancreatic beta-cell morphology and enhances insulin secretion in vivo. Am J Physiol Endocrinol Metab. 298:E1261-E1273. DOI.
  • Sun G; Tarasov AI; McGinty J; McDonald A; da Silva Xavier G; Gorman T; Marley A; French PM; et alParker H; Gribble F; Reimann F; Prendiville O; Carzaniga R; Viollet B; Leclerc I; Rutter GA. (May 2010). Ablation of AMP-activated protein kinase alpha1 and alpha2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo. Diabetologia. 53:924-936. DOI.
  • McDonald A; Fogarty S; Leclerc I; Hill EV; Hardie DG; Rutter GA. (Feb 2010). Cell-wide analysis of secretory granule dynamics in three dimensions in living pancreatic beta-cells: evidence against a role for AMPK-dependent phosphorylation of KLC1 at Ser517/Ser520 in glucose-stimulated insulin granule movement. Biochem Soc Trans. 38:205-208. DOI.
  • Noordeen NA; Khera TK; Sun G; Longbottom ER; Pullen TJ; da Silva Xavier G; Rutter GA; Leclerc I. (Jan 2010). Carbohydrate-responsive element-binding protein (ChREBP) is a negative regulator of ARNT/HIF-1beta gene expression in pancreatic islet beta-cells. Diabetes. 59:153-160. DOI.
  • Sun G; Xavier GDS; Riboulet-Chavey A; Taneja T; Leclerc I; Rutter GA. (1 Sep 2008). Over-expression of constitutively-activated or dominant-negative forms of AIMP-activated protein kinase (AMPK) selectively in the beta cells of transgenic mice exerts opposing effects on glucose tolerance. DIABETOLOGIA. 51:S202-S202. Author weblink.
  • MacDonald ST; Bamforth SD; Chen C-M; Farthing CR; Franklyn A; Broadbent C; Schneider JE; Saga Y; et alLewandoski M; Bhattacharya S. (1 Aug 2008). Epiblastic Cited2 deficiency results in cardiac phenotypic heterogeneity and provides a mechanism for haploinsufficiency. CARDIOVASCULAR RESEARCH. 79:448-457. Author weblink DOI.
  • Rutter GA; Leclerc I. (15 Jan 2009). The AMP-regulated kinase family: enigmatic targets for diabetes therapy. Mol Cell Endocrinol. 297:41-49. DOI.
  • Jacquet S; Zarrinpashneh E; Chavey A; Ginion A; Leclerc I; Viollet B; Rutter GA; Bertrand L; et alMarber MS. (1 Dec 2007). The relationship between p38 mitogen-activated protein kinase and AMP-activated protein kinase during myocardial ischemia. CARDIOVASCULAR RESEARCH. 76:465-472. Author weblink DOI.
  • Tsuboi T; da Silva Xavier G; Leclerc I; Rutter GA. (26 Dec 2003). 5'-AMP-activated protein kinase controls insulin-containing secretory vesicle dynamics. J Biol Chem. 278:52042-52051. DOI.
  • Leclerc I; da Silva Xavier G; Rutter GA. (2002). AMP- and stress-activated protein kinases: key regulators of glucose-dependent gene transcription in mammalian cells?. Prog Nucleic Acid Res Mol Biol. 71:69-90.
  • Leclerc I; Rutter GA. (Dec 2004). AMP-activated protein kinase: a new beta-cell glucose sensor?: Regulation by amino acids and calcium ions. Diabetes. 53 Suppl 3:S67-S74.
  • da Silva Xavier G; Rutter GA; Diraison F; Andreolas C; Leclerc I. (Nov 2006). ChREBP binding to fatty acid synthase and L-type pyruvate kinase genes is stimulated by glucose in pancreatic beta-cells. J Lipid Res. 47:2482-2491. DOI.
  • Zhang P; Bennoun M; Gogard C; Bossard P; Leclerc I; Kahn A; Vasseur-Cognet M. (Nov 2002). Expression of COUP-TFII in metabolic tissues during development. Mech Dev. 119:109-114.
  • Xavier GD; Leclerc I; Rutter GA. (1 Jun 2002). Glucose-regulated gene expression via inhibition of AMP-activated protein kinase and activated insulin secretion in MIN6 pancreatic beta cells. DIABETES. 51:A2-A2. Author weblink.
  • Leclerc I; Lenzner C; Gourdon L; Vaulont S; Kahn A; Viollet B. (Jul 2001). Hepatocyte nuclear factor-4alpha involved in type 1 maturity-onset diabetes of the young is a novel target of AMP-activated protein kinase. Diabetes. 50:1515-1521.
  • Rutter GA; Leclerc I; Tsuboi T; Xavier GDAS; Diraison F; Qian Q. (2004). Imaging glucose-regulated insulin secretion and gene expression in single islet beta-cells: control by AMP-activated protein kinase. Cell Biochem Biophys. 40:179-190.
  • Diraison F; Motakis E; Parton LE; Nason GP; Leclerc I; Rutter GA. (Dec 2004). Impact of adenoviral transduction with SREBP1c or AMPK on pancreatic islet gene expression profile: analysis with oligonucleotide microarrays. Diabetes. 53 Suppl 3:S84-S91.
  • Ma D; Shield JP; Dean W; Leclerc I; Knauf C; Burcelin R R; Rutter GA; Kelsey G. (Aug 2004). Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDM. J Clin Invest. 114:339-348. DOI.
  • Bourdeau I; Bard C; Noël B; Leclerc I; Cordeau MP; Bélair M; Lesage J; Lafontaine L; et alLacroix A. (May 2002). Loss of brain volume in endogenous Cushing's syndrome and its reversibility after correction of hypercortisolism. J Clin Endocrinol Metab. 87:1949-1954.
  • Leclerc I; Woltersdorf WW; da Silva Xavier G; Rowe RL; Cross SE; Korbutt GS; Rajotte RV; Smith R; et alRutter GA. (Jun 2004). Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion. Am J Physiol Endocrinol Metab. 286:E1023-E1031. DOI.
  • Richards SK; Parton LE; Leclerc I; Rutter GA; Smith RM. (Nov 2005). Over-expression of AMP-activated protein kinase impairs pancreatic {beta}-cell function in vivo. J Endocrinol. 187:225-235. DOI.
  • Diraison F; Parton L; Ferré P; Foufelle F; Briscoe CP; Leclerc I; Rutter GA. (15 Mar 2004). Over-expression of sterol-regulatory-element-binding protein-1c (SREBP1c) in rat pancreatic islets induces lipogenesis and decreases glucose-stimulated insulin release: modulation by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR). Biochem J. 378:769-778. DOI.
  • da Silva Xavier G; Leclerc I; Varadi A; Tsuboi T; Moule SK; Rutter GA. (1 May 2003). Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression. Biochem J. 371:761-774. DOI.
  • Leclerc I; Fernandez-Millan E; Nyirenda M; Rutter GA. (1 Mar 2007). Role of AMP-activated protein kinase in glucagon secretion. DIABETIC MEDICINE. 24:1-1. Author weblink.
  • Leclerc I; Viollet B; da Silva Xavier G; Kahn A; Rutter GA. (Apr 2002). Role of AMP-activated protein kinase in the regulation of gene transcription. Biochem Soc Trans. 30:307-311.
  • Rutter GA; Da Silva Xavier G; Leclerc I. (1 Oct 2003). Roles of 5'-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis. Biochem J. 375:1-16. DOI.
  • Rencurel F; Foretz M; Kaufmann MR; Stroka D; Looser R; Leclerc I; da Silva Xavier G; Rutter GA; et alViollet B; Meyer UA. (Dec 2006). Stimulation of AMP-activated protein kinase is essential for the induction of drug metabolizing enzymes by phenobarbital in human and mouse liver. Mol Pharmacol. 70:1925-1934. DOI.

Conferences

  • Noordeen NA; Meur G; Patel P; Rutter GA; Leclerc I. Carbohydrate-Responsive Element-Binding Protein (ChREBP) activity is regulated by Ca2+ ions in pancreatic beta cells via soluble resistant-related calcium binding protein (Sorcin). 46th Annual Meeting of the European-Association-for-the- Study-of-Diabetes (EASD), 20 Sep 2010 - 24 Sep 2010. 53:S91-S92. SPRINGER (1 Sep 2010).
  • Sun G; Xavier GD; Riboulet-Chavey A; Taneja T; Leclerc I; Rutter GA. Over-expression of constitutively-activated or dominant-negative forms of AIMP-activated protein kinase (AMPK) selectively in the beta cells of transgenic mice exerts opposing effects on glucose tolerance. 44th Annual Meeting of the European-Association-for-the-Study-of-Diabetes. 51:S202-S202. (Sep 2008).
  • Rutter GA; Ma D; Shield JPH; Dean W; Leclerc I; Knauf C; Burcelin R; Kelsey G. Altered glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus (TNDM) locus. 40th Annual Meeting of the European-Association-for-the-Study-of-Diabetes. 47:A53-A54. (Aug 2004).
  • Richards SK; Parton LE; Leclerc I; Rutter GA; Smith RM. AMP-activated protein kinase (AMPK) activity in murine islet isografts as a determinant of recipient glycaemic control. 65th Annual Meeting of the American-Diabetes-Association, 10 Jun 2005 - 14 Jun 2005. 54:A480-A480. AMER DIABETES ASSOC (1 Jan 2005). Author weblink.
  • Xavier GD; Diraison F; Qian Q; Rutter GA; Leclerc I. Carbohydrate response-element binding protein regulates liver-type pyruvate kinase and pancreatic duodenum homeobox-1 expression in MIN6 beta-cells by direct and indirect mechanisms, respectively. 41st Annual Meeting of the European-Association-for-the-Study-of-Diabetes. 48:A157-A157. (Jan 2005).
  • Diraison F; Xavier GD; Motakis E; Nason GP; Rutter GA; Leclerc I. Impact of over-expression of carbohydrate response-element binding-protein (ChREBP) on pancreatic beta-cell gene expression profile and insulin secretion. 40th Annual Meeting of the European-Association-for-the-Study-of-Diabetes. 47:A162-A162. (Aug 2004).
  • Rutter GA; Richards SK; Parton LE; Leclerc I; Smith RM. Over-expression of activated AMP-activated protein kinase (AMPK) impairs in vivo pancreatic beta-cell function in transplanted pancreatic islets. 41st Annual Meeting of the European-Association-for-the-Study-of-Diabetes. 48:A88-A88. (Jan 2005).
  • Richards SK; LeClerc I; Mathieson PW; Morgan JDT; Rutter GA; Smith RM. The effect of AMP-activated protein kinase on success rate and glycaemic control of murine islet isografts. Annual Meeting of the Association-of-Surgeons-of-Great-Britian-and-Ireland. 92:34-34. (Apr 2005).
  • Jacquet S; Zarrinpashneh E; Chavey A; Leclerc I; Rutter GA; Bertrand L; Marber MS. The relationship between P38-MAPK and AMPK during myocardial ischaernia. 19th World Congress of the ISHR, 22 Jun 2007 - 25 Jun 2007. 42:S52-S52. ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD (1 Jun 2007). Author weblink DOI.
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