Publications

Journals

• Corware K; Harris D; Teo I; Rogers M; Naresh K; Müller I; Shaunak S. (Nov 2011). Accelerated healing of cutaneous leishmaniasis in non-healing BALB/c mice using water soluble amphotericin B-polymethacrylic acid. Biomaterials. 32:8029-8039. DOI.
• Fu H; Khan A; Coe D; Zaher S; Chai JG; Kropf P; Müller I; Larkin DF; et alGeorge AJ. (Oct 2011). Arginine depletion as a mechanism for the immune privilege of corneal allografts. Eur J Immunol. 41:2997-3005. DOI.
• Kropf P; Kadolsky UD; Rogers M; Cloke TE; Mueller I. Kabelitz D (ed); Kaufmann SHE (ed). (1 Jan 2010). The Leishmaniasis Model. IMMUNOLOGY OF INFECTION, THIRD EDITION. 37:307-328. DOI.
• Cloke TE; Abebe T; Hailu A; Munder M; Taylor GP; Müller I; Kropf P. (Nov 2010). Antiretroviral therapy abrogates association between arginase activity and HIV disease severity. Trans R Soc Trop Med Hyg. 104:746-748. DOI.
• Corware KD; Rogers M; Teo I; Müller I; Shaunak S. (Nov 2010). An amphotericin B-based drug for treating experimental Leishmania major infection. Trans R Soc Trop Med Hyg. 104:749-750. DOI.
• Rogers ME; Corware K; Müller I; Bates PA. (Oct 2010). Leishmania infantum proteophosphoglycans regurgitated by the bite of its natural sand fly vector, Lutzomyia longipalpis, promote parasite establishment in mouse skin and skin-distant tissues. Microbes Infect. 12:875-879. DOI.
• Cloke TE; Garvey L; Choi BS; Abebe T; Hailu A; Hancock M; Kadolsky U; Bangham CR; et alMunder M; Müller I; Taylor GP; Kropf P. (15 Aug 2010). Increased level of arginase activity correlates with disease severity in HIV-seropositive patients. J Infect Dis. 202:374-385. DOI.
• Clements MF; Gidwani K; Kumar R; Hostomska J; Dinesh DS; Kumar V; Das P; Mueller I; et alHamilton G; Volfova V; Boelaert M; Das M; Rijal S; Picado A; Volf P; Sundar S; Davies CR; Rogers ME. (1 May 2010). Measurement of Recent Exposure to Phlebotomus argentipes, the Vector of Indian Visceral Leishmaniasis, by Using Human Antibody Responses to Sand Fly Saliva. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 82:801-807. Author weblink DOI.
• Oberlies J; Watzl C; Giese T; Luckner C; Kropf P; Mueller I; Ho AD; Munder M. (1 May 2009). Regulation of NK Cell Function by Human Granulocyte Arginase. JOURNAL OF IMMUNOLOGY. 182:5259-5267. DOI.
• Luckner-Minden C; Fischer I; Langhans CD; Schiller M; Kropf P; Müller I; Hohlfeld JM; Ho AD; et alMunder M. (Jun 2010). Human eosinophil granulocytes do not express the enzyme arginase. J Leukoc Biol. 87:1125-1132. DOI.
• Mueller I; Munder M; Kropf P; Haensch GM. (1 Nov 2009). Polymorphonuclear neutrophils and T lymphocytes: strange bedfellows or brothers in arms?. TRENDS IN IMMUNOLOGY. 30:522-530. Author weblink DOI.
• Rogers M; Kropf P; Choi B-S; Dillon R; Podinovskaia M; Bates P; Mueller I. (1 Aug 2009). Proteophosophoglycans Regurgitated by Leishmania-Infected Sand Flies Target the L-Arginine Metabolism of Host Macrophages to Promote Parasite Survival. PLOS PATHOGENS. 5. Author weblink DOI Open Access copy.
• Modolell M; Choi B-S; Ryan RO; Hancock M; Titus RG; Abebe T; Hailu A; Mueller I; et alRogers ME; Bangham CRM; Munder M; Kropf P. (1 Jul 2009). Local Suppression of T Cell Responses by Arginase-Induced L-Arginine Depletion in Nonhealing Leishmaniasis. PLOS NEGLECTED TROPICAL DISEASES. 3. Author weblink DOI.
• Muller I; Hailu A; Choi B-S; Abebe T; Fuentes JM; Munder M; Modolell M; Kropf P. (1 May 2008). Age-Related Alteration of Arginase Activity Impacts on Severity of Leishmaniasis. PLOS NEGLECTED TROPICAL DISEASES. 2. Author weblink DOI.
• Choi BS; Martinez-Falero IC; Corset C; Munder M; Modolell M; Müller I; Kropf P. (Feb 2009). Differential impact of L-arginine deprivation on the activation and effector functions of T cells and macrophages. J Leukoc Biol. 85:268-277. DOI.
• Kropf P; Baud D; Marshall SE; Munder M; Mosley A; Fuentes JM; Bangham CR; Taylor GP; et alHerath S; Choi BS; Soler G; Teoh T; Modolell M; Müller I. (Apr 2007). Arginase activity mediates reversible T cell hyporesponsiveness in human pregnancy. Eur J Immunol. 37:935-945. DOI.
• Munder M; Schneider H; Luckner C; Giese T; Langhans CD; Fuentes JM; Kropf P; Mueller I; et alKolb A; Modolell M; Ho AD. (1 Sep 2006). Suppression of T-cell functions by human granulocyte arginase. Blood. 108:1627-1634. DOI.
• Kropf P; Fuentes JM; Fähnrich E; Arpa L; Herath S; Weber V; Soler G; Celada A; et alModolell M; Müller I. (Jun 2005). Arginase and polyamine synthesis are key factors in the regulation of experimental leishmaniasis in vivo. FASEB J. 19:1000-1002. DOI.
• Antoniazi S; Price HP; Kropf P; Freudenberg MA; Galanos C; Smith DF; Müller I. (Sep 2004). Chemokine gene expression in toll-like receptor-competent and -deficient mice infected with Leishmania major. Infect Immun. 72:5168-5174. DOI.
• Kropf P; Freudenberg N; Kalis C; Modolell M; Herath S; Galanos C; Freudenberg M; Müller I. (Jul 2004). Infection of C57BL/10ScCr and C57BL/10ScNCr mice with Leishmania major reveals a role for Toll-like receptor 4 in the control of parasite replication. J Leukoc Biol. 76:48-57. DOI.
• Kropf P; Freudenberg MA; Modolell M; Price HP; Herath S; Antoniazi S; Galanos C; Smith DF; et alMüller I. (Apr 2004). Toll-like receptor 4 contributes to efficient control of infection with the protozoan parasite Leishmania major. Infect Immun. 72:1920-1928.
• Herath S; Kropf P; Müller I. (Nov 2003). Cross-talk between CD8(+) and CD4(+) T cells in experimental cutaneous leishmaniasis: CD8(+) T cells are required for optimal IFN-gamma production by CD4(+) T cells. Parasite Immunol. 25:559-567. DOI.
• Kropf P; Herath S; Weber V; Modolell M; Müller I. (Aug 2003). Factors influencing Leishmania major infection in IL-4-deficient BALB/c mice. Parasite Immunol. 25:439-447.
• Kropf P; Herath S; Klemenz R; Müller I. (Apr 2003). Signaling through the T1/ST2 molecule is not necessary for Th2 differentiation but is important for the regulation of type 1 responses in nonhealing Leishmania major infection. Infect Immun. 71:1961-1971.
• Herath, S; Kropf, P; Muller, I. (2003). Cross talk between CD8+ and CD4+ T cells in experimental leishmaniasis: CD8+ T cells are required for optimal IFN-gamma production by CD4+ T cells. Parasite Immunology. 25:559-2567.
• Kropf P; Herath S; Tewari R; Syed N; Klemenz R; Müller I. (Oct 2002). Identification of two distinct subpopulations of Leishmania major-specific T helper 2 cells. Infect Immun. 70:5512-5520.
• Kropf P; Bickle Q; Herath S; Klemenz R; Müller I. (Sep 2002). Organ-specific distribution of CD4+ T1/ST2+ Th2 cells in Leishmania major infection. Eur J Immunol. 32:2450-2459. DOI.
• Kropf P; Muller I; Brunson K. (1 Jan 2002). The leishmaniasis model. IMMUNOLOGY OF INFECTION, SECOND EDITION. 32:463-492. Author weblink.
• Marshall BG; Kropf P; Murray K; Clark C; Flanagan AM; Davidson RN; Shaw RJ; Müller I. (May 2000). Bronchopulmonary and mediastinal leishmaniasis: an unusual clinical presentation of Leishmania donovani infection. Clin Infect Dis. 30:764-769. DOI.
• Kropf P; Schopf LR; Chung CL; Xu D; Liew FY; Sypek JP; Müller I. (Nov 1999). Expression of Th2 cytokines and the stable Th2 marker ST2L in the absence of IL-4 during Leishmania major infection. Eur J Immunol. 29:3621-3628. DOI.
• Etges R; Müller I. (May 1998). Progressive disease or protective immunity to Leishmania major infection: the result of a network of stimulatory and inhibitory interactions. J Mol Med (Berl). 76:372-390.
• Kropf P; Muller I; Brunson K; Etges R. (1 Jan 1998). The Leishmaniasis model. METHODS IN MICROBIOLOGY, VOL 25. 25:419-458. Author weblink.
• Kropf P; Etges R; Schopf L; Chung C; Sypek J; Müller I. (1 Oct 1997). Characterization of T cell-mediated responses in nonhealing and healing Leishmania major infections in the absence of endogenous IL-4. J Immunol. 159:3434-3443.
• Müller I; Freudenberg M; Kropf P; Kiderlen AF; Galanos C. (Oct 1997). Leishmania major infection in C57BL/10 mice differing at the Lps locus: a new non-healing phenotype. Med Microbiol Immunol. 186:75-81.
• Noben-Trauth N; Kropf P; Müller I. (16 Feb 1996). Susceptibility to Leishmania major infection in interleukin-4-deficient mice. Science. 271:987-990.
• Kantengwa S; Müller I; Louis J; Polla BS. (Feb 1995). Infection of human and murine macrophages with Leishmania major is associated with early parasite heat shock protein synthesis but fails to induce a host cell stress response. Immunol Cell Biol. 73:73-80. DOI.
• Müller I; Kropf P; Louis JA; Milon G. (Jun 1994). Expansion of gamma interferon-producing CD8+ T cells following secondary infection of mice immune to Leishmania major. Infect Immun. 62:2575-2581.
• de Kossodo S; Grau GE; Louis JA; Müller I. (Apr 1994). Tumor necrosis factor alpha (TNF-alpha) and TNF-beta and their receptors in experimental cutaneous leishmaniasis. Infect Immun. 62:1414-1420.
• Stefani MM; Müller I; Louis JA. (Mar 1994). Leishmania major-specific CD8+ T cells are inducers and targets of nitric oxide produced by parasitized macrophages. Eur J Immunol. 24:746-752. DOI.
• Müller I; Kropf P; Etges RJ; Louis JA. (Sep 1993). Gamma interferon response in secondary Leishmania major infection: role of CD8+ T cells. Infect Immun. 61:3730-3738.
• Stefani MM; Müller I; Louis J. (May 1993). Leishmania major infection in BALB/c mice: protection or exacerbation by treatment with different doses of BCG. Res Immunol. 144:233-243.
• Rossi-Bergmann B; Müller I; Godinho EB. (May 1993). TH1 and TH2 T-cell subsets are differentially activated by macrophages and B cells in murine leishmaniasis. Infect Immun. 61:2266-2269.
• Louis, J; Rosat, J P; Frith, U; Muller I; Aguet, M; Milon, G. (1993). T cell subsets triggered by L. major in mice: Study of their effector functions and of some parameters influencing their differentiation. Mem. Inst. 88 supl:44-45.
• Müller I. (Dec 1992). Role of T cell subsets during the recall of immunologic memory to Leishmania major. Eur J Immunol. 22:3063-3069. DOI.
• Röcken M; Müller KM; Saurat JH; Müller I; Louis JA; Cerottini JC; Hauser C. (1 Jan 1992). Central role for TCR/CD3 ligation in the differentiation of CD4+ T cells toward A Th1 or Th2 functional phenotype. J Immunol. 148:47-54.
• Müller I; Fruth U; Louis JA. (1992). Immunobiology of experimental leishmaniasis. Med Microbiol Immunol. 181:1-12.
• Müller I; Pedrazzini T; Kropf P; Louis J; Milon G. (Jun 1991). Establishment of resistance to Leishmania major infection in susceptible BALB/c mice requires parasite-specific CD8+ T cells. Int Immunol. 3:587-597.
• Titus RG; Müller I; Kimsey P; Cerny A; Behin R; Zinkernagel RM; Louis JA. (Mar 1991). Exacerbation of experimental murine cutaneous leishmaniasis with CD4+ Leishmania major-specific T cell lines or clones which secrete interferon-gamma and mediate parasite-specific delayed-type hypersensitivity. Eur J Immunol. 21:559-567. DOI.
• Müller I; Milon G; Louis J. (Feb 1991). T-cell responses during infections with Leishmania major. Behring Inst Mitt. 80-83.
• Del Giudice G; Grillot D; Rénia L; Müller I; Corradin G; Louis JA; Mazier D; Lambert PH. (Aug 1990). Peptide-primed CD4+ cells and malaria sporozoites. Immunol Lett. 25:59-63.
• Grillot D; Michel M; Müller I; Tougne C; Rènia L; Mazier D; Corradin G; Lambert PH; et alLouis JA; Del Guidice G. (Jun 1990). Immune responses to defined epitopes of the circumsporozoite protein of the murine malaria parasite, Plasmodium yoelii. Eur J Immunol. 20:1215-1222. DOI.
• Müller I; Garcia-Sanz JA; Titus R; Behin R; Louis J. (Dec 1989). Analysis of the cellular parameters of the immune responses contributing to resistance and susceptibility of mice to infection with the intracellular parasite, Leishmania major. Immunol Rev. 112:95-113.
• Müller I; Louis JA. (May 1989). Immunity to experimental infection with Leishmania major: generation of protective L3T4+ T cell clones recognizing antigen(s) associated with live parasites. Eur J Immunol. 19:865-871. DOI.
• Farrell JP; Muller I; Louis JA. (15 Mar 1989). A role for Lyt-2+ T cells in resistance to cutaneous leishmaniasis in immunized mice. J Immunol. 142:2052-2056.
• Müller I; Pedrazzini T; Farrell JP; Louis J. (1989). T-cell responses and immunity to experimental infection with leishmania major. Annu Rev Immunol. 7:561-578. DOI.
• Müller I; Pedrazzini T; Louis JA. (Nov 1988). Experimentally induced cutaneous leishmaniasis: are L3T4+ T cells that promote parasite growth distinct from those mediating resistance?. Immunol Lett. 19:251-259.
• Müller I; Cobbold SP; Waldmann H; Kaufmann SH. (Sep 1987). Impaired resistance to Mycobacterium tuberculosis infection after selective in vivo depletion of L3T4+ and Lyt-2+ T cells. Infect Immun. 55:2037-2041.
• Louis JA; Pedrazzini T; Titus RG; Muller I; Farrell JP; Kindler V; Vassalli P; Marchal G; et alMilon G. (Sep 1987). Subsets of specific T cells and experimental cutaneous leishmaniasis. Ann Inst Pasteur Immunol. 138:755-758.
• Müller I; Maier B; Brinkmann V; Kaufmann SH. (Jul 1986). Autoreactive T cell clones from mice infected with Mycobacterium bovis, strain Bacillus Calmette-Guérin (BCG). I. Phenotype, specificity and in vitro function. Immunobiology. 171:366-380.
• Müller I; Kaufmann SH. (Sep 1985). Antigen-reactivity pattern of T-cell hybridomas from Mycobacterium bovis BCG-infected mice. Infect Immun. 49:838-840.
• Kaufmann SH; Eichmann K; Müller I; Wrazel LJ. (Jun 1985). Vaccination against the intracellular bacterium Listeria monocytogenes with a clonotypic antiserum. J Immunol. 134:4123-4127.
• Kaufmann SH; Hug E; Väth U; Müller I. (Apr 1985). Effective protection against Listeria monocytogenes and delayed-type hypersensitivity to listerial antigens depend on cooperation between specific L3T4+ and Lyt 2+ T cells. Infect Immun. 48:263-266.
• Antoniazi-Pereira S; Kropf P; Price H; Freudenberg M; Galanos C; Smith D; Muller I. Chemokine expression in Leishmania major infected Toll-like receptor competent and deficient mice. Infect Immun.
• Muller, I; Kropf, P; Louis, J. Comparison of the IFN-γ response in Leishmania major immune and reinfected mice and alanysis of the contribution of CD8+ T lymphocytes. Men. Inst. 87 supl:50-51.

Chapters in books

• Kropf P; Muller I. IL-4 Knock-out mice. In Cytokine Knockouts, 2nd Edition. 187-202. Fantuzzi G (ed). Humana Press, Totowa, New Jersey, USA (2003).
• Kropf P; Brunson K; Muller I. The Leishmaniasis Model. In Immunology of Infection, part of Methods in Microbiology Series, 2nd Edition. 463-492. SHE K (ed); Kabelitz D (ed). Academic Press Ltd, London (2002).
• Muller, I; Kropf, P; Milon, G; Louis, J. CD8+ T lymphocytes in experimental murine cutaneous leishmaniasis. In New advances on cytokines. 92:265-270. Romagnani S (ed); Mosmann TR (ed); Abbas AK (ed). Raven Press (1992).
• Louis, J A; Fruth, J P; Rosat, F; Conceicao-Silva, F; Perlaza, B; Romero, P; Muller, I; Milon, G. The analysis of the function and specificity of T cells triggered during infection with Leishmania, its importance for the rational dsign of a vaccine. In Progress in Immunology (8th International Congress of Immunology). 8:775-782. (1992).
• Louis, J A; Muller, I. Experimental infection of mice with Leishmania major: Analysis of the role of T cells in resistance and susceptibility. In Progress in Immunology. 971-978. Melchers FEA (ed). Springer Verlag, Berlin (1989).
• Muller, I; Pedrazzini, T; Louis, J A. Importance of specific T cell responses in experimental leishmaniasis. In Immune disorders and opportunistic infections, Local Immunity. 140-146. Revillard JP (ed); Wierzbicki N (ed). Fondation Franco-Allemande, Suresnes, France (1989).
• Muller, I; Titus, R; Caldumbide, I; Louis, J A. T cell responses in resistance and susceptibility to experimental infection with Leishmania major. In Frontiers of infectious diseases "New strategies in Parasitology. 158-175. Adam M (ed); al KE (ed). Churchill Livingston, London (1989).
• Kaufmann, S H E; Flesch, I; Muller, I; Chiplunkar, S; de Libero, G. Macrophages, helper T cells and cytolytic T cells: Possible contribution to host defense against mycobacteria. In Bacteria-host cell interaction. 311-325. Horwitz M (ed). Alan R Liss Inc., New York (1988).
• Muller, I; Pedrazzini, T; Louis, J A. Specific T cell responses in experimental leishmaniasis. In Topics in immunology. Ninth European Meeting. 169-179. Aiuti F (ed); Bonomo L (ed); Danieli G (ed). Il pensiero scientifico editore, Rome, Italy (1988).
• Muller, I; Rolink, A; Freudenberg, N; Kaufmann, S H E. Biological functions in vitro and in vivo of cloned autoreactive T cells from Mycobacterium bovis BCG infected mice. In Leukocytes and host defense. 325-330. Oppenheim JJ (ed); Jacobs DM (ed). Alan R. Liss Inc, New York (1986).
• Kaufmann, S H E; Eichmann, K; Muller, I; Wrazel, L J. Protection against Listeria monocytogenes with a clonotypic antiserum. In Leukocytes and host defense. 331-336. Oppenheim JJ (ed); Jacobs DM (ed). Alan R Liss, New York (1986).
• Kaufmann, S E H; Brinkmann, A F; Kiderlen, A F; Lohmann-Matthes, M-L; Muller, I; Wrazel, L J. Role of T-lymphocyte clones in cell-mediated immunity. In Mononuclear phagocytes, characteristics, physiology and function. 541-550. Furth RV (ed). Martin Nijhoff Publishers, Dorecht (1985).
• Kaufmann, S H E; Lohmann-Matthes, M-L; Brinkmann, V; Wrazel, J; Muller, I. T-lymphocytemacrophage interactions in leprosy: Studies with murine T-cell-clones. In The macrophage in leprosy. 139-158. The foundation for medical research, Bombay (1984).

Conferences

• Cloke T; Garvey L; Choi B-S; Bangham CRB; Muller I; Taylor G; Kropf P. Arginase-induced L-arginine metabolism in HIV-infected patients. Annual Congress of the British-Society-of-Immunology, 17 Nov 2008 - 21 Nov 2008. 125:133-133. WILEY-BLACKWELL PUBLISHING, INC (1 Dec 2008). Author weblink.
• Hancock A; Choi B-S; Ryan RO; Muller I; Titus RG; Munder M; Rogers M; Bangham CRM; et alModolell M; Kropf P. Local suppression of T cell responses by arginase-induced L-arginine depletion in non-heating leishmaniasis. Annual Congress of the British-Society-of-Immunology, 17 Nov 2008 - 21 Nov 2008. 125:127-127. WILEY-BLACKWELL PUBLISHING, INC (1 Dec 2008). Author weblink.
• Rogers M; Ilg T; Sizova O; Nikolaev A; Ferguson M; Muller I; Bates P. Leishmania transmission from the sand fly vector: parasite secretory gel. Annual Congress of the British-Society-of-Immunology. 120:63-63. (Mar 2007).
• Kropf P; Freudenberg M; Modolell M; Price H; Herath S; Antoniazi S; Galanos C; Smith S; et alMuller I. Bone marrow macrophages from TLR4-deficient mice display an impaired capacity to control the replication of Leishmania major parasites. 17th Meeting of the EMDS. (2003).
• Kropf P; Freudenberg M; Modolell M; Price H; Herath S; Antoniazi S; Galanos C; Smith I; et alMuller I. Toll-like receptor 4 contributes to the efficient control of infection with the protozoan parasite Leishmania major. International Cytokine Society, 20 Sep 2003 - 24 Sep 2003. (2003).
• Muller I; Herath S; Kropf P. Ageing alters the course of nonhealing Leishmania major infections in IL-4 deficient BALB/c mice. Immunoparasitology Meeting, 26 Apr 2002 - 1 May 2002. (2002).
• Herath S; Kropf P; Muller I. Cross-talk between CD8* and cells in experimental cutaneous leishmaniasis. Immunoparasitology Meeting, 26 Apr 2002 - 1 May 2002. (2002).
• Kropf P; Herath S; Bickle Q; Tewari R; Syed N; Klemenz R; Muller I. Organ-specific distribution and cytokine production of CD4* T 1/ST2+ T cells in Leishmania major infected mice. Immunoparasitology Meeting, 26 Apr 2002 - 1 May 2002. (2002).
• Kropf P; Herath S; Klemenz R; Muller I. Signalling through the T1/ST2 molecule is not necessary for Th2 differentiation, but is important for the regulation of type 1 responses in nonhealing Lesmania major infection. British Society for Parasitology, Trypanosomiasis and Leishmaniasis seminar, 8 Sep 2002 - 11 Sep 2002. (2002).
• Roe T; Lukey P; Muller I; Young D. TGF-beta and mycobacterial infection. 5th International Congress on the Pathogenesis of Mycobacterial infections, 27 Jun 2002 - 30 Jun 2002. (2002).