Dr Ivan Yap

A. Personal Statement:

I am currently the analytical chemist and chemometrician for the INTERMAP metabolomics program investigating the relationship between urinary metabolite patterns with blood pressure (BP). I work closely with PIs (Professor Nicholson, Professor Holmes and Professor Elliot) and my responsibilities include data management, analyzing complex urinary NMR spectra, relate urinary NMR data with nutritional and demographic data using chemometrics, interpretation, and report writing. I have been working with INTERMAP London Coordinating Centre under the leadership of Professor Elliot since 2005. I have 8 years experience managing, analyzing and interpreting metabonomics data from various studies. I contribute to numerous projects spanning a diverse range of application areas including cardiovascular and nutritional epidemiology, inborn errors of metabolism, parasitology and has acquired expertise in multivariate statistical analysis. I am a co-investigator in the Australian Rotary Health: Autism Grant (A$35,684.00). I have also developed a network of collaborations both within Imperial College (Neonatal Medicine Department) and with external groups including Canterbury Christ Church University (UK) and University of South Australia.

B.    Positions and Honors

Position
2005- current: Research Associate, Imperial College London, UK

Other Experience, Professional Memberships
2006-2010            Member, Royal Society of Chemistry
2007-2010            Member, British Society for Parasitology
2008-2010            Member, National Autistic Society

Honors
1998            British Scholarship Scheme
2001            E de Barry Barnett Prize (Chemical Sciences) for Outstanding Achievement
2002-2005 Higher Education Funding Council for England (HEFCE), Overseas Research Scholarship

Publications List:

Martin FP, Verdu EF, Wang Y, Dumas ME, Yap IKS, Cloarec O, Bergonzelli GE, Corthesy-Theulaz I, Kochhar S, Holmes E, Lindon JC, Collins SM, Nicholson JK. ‘Transgenomic metabolic interactions in a mouse disease model: Interactions of Trichinella spiralis Infection with Dietary Lactobacillus paracasei Supplementation’ J. Proteome Res. 2006, 5(9), 2185-2193.

Yap IKS, Clayton TA, Tang H, Everett JR, Hanton G, Provost JP, Le Net JL, Charuel C, Lindon JC, Nicholson JK. ‘An integrated metabonomic approach to describe temporal metabolic disregulation induced in the rat by the model hepatotoxin allyl formate’ J. Proteome Res. 2006, 5(10), 2675-2684.

Martin FP, Dumas ME, Wang Y, Legido-Quigley C, Yap IKS, Tang H, Zirah S, Murphy GM, Cloarec O, Lindon JC, Sprenger N, Fay LB, Kochhar S, van Bladeren P, Holmes E, Nicholson JK. ‘A top-down systems biology view of microbiomemammalian metabolic interactions in a mouse model’ Mol. Syst. Biol. 2007, 3, 112.

Skordi E, Yap IKS, Claus SP, Martin FP, Cloarec O, Lindberg J, Schuppe-Koistinen I, Holmes E, Nicholson JK. ‘Analysis of Time-Related Metabolic Fluctuations Induced by Ethionine in the Rat’ J. Proteome Res. 2007, 6(12), 4572-4581.

Martin FP, Wang Y, Sprenger N, Yap IKS, Lundstedt T, Lek P, Rezzi S, Ramadan Z, van Bladeren P, Fay LB, Kochhar S, Lindon JC, Holmes E, Nicholson JK. ‘Probiotic modulation of symbiotic gut microbial–host metabolic interactions in a humanized microbiome mouse model’ Mol. Syst. Biol. 2008, 4, 157.

Holmes E, Loo RL, Stamler J, Bictash M, Yap IKS, Chan Q, Ebbels T, De Iorio M, Brown IJ, Veselkov K, Daviglus M, Kesteloot H, Ueshima H, Zhao L, Nicholson JK, Elliott P. ‘Diversity of Urinary Metabolic Phenotypes across Human Populations and Associations with Diet and Blood Pressure’ Nature, 2008, 453, 396-400.

Martin FP, Wang Y, Sprenger N, Yap IKS, Rezzi S, Ramadan Z, Pere´-Trepat E, Rochat F, Cherbut C, van Bladeren P, Fay LB, Kochhar S, Lindon JC, Holmes E, Nicholson JK. ‘Top-down systems biology integration of conditional prebiotic modulated transgenomic interactions in a humanized microbiome mouse model’ Mol. Syst. Biol. 2008, 4, 205.

Yap IKS, Li JV, Saric J, Martin FP, Davies H, Wang Y, Wilson ID, Nicholson JK, Utzinger J, Marchesi JR, Holmes E. ‘Metabonomic and Microbiological Analysis of the Dynamic Effect of Vancomycin-induced Gut Microbiota Modification in Mice’ J. Proteome Res., 2008, 7, 3718-3728.

Martin FP, Sprenger N, Yap IKS, Wang Y, Bibiloni R, Rochat F, Rezzi S, Cherbut C, Kochhar S, Lindon J, Holmes E, Nicholson J. ‘Panorganismal gut microbiome-host metabolic crosstalk’ J. Proteome Res., 2009, 8, 2090-2105.

Martin FP, Wang Y, Yap IKS, Sprenger N, Lindon JC, Rezzi S, Kochhar S, Elaine Holmes E, Nicholson JK ‘Topographical variation in murine intestinal metabolic profiles in relation to microbiome speciation and functional ecological activity’ J. Proteome Res., 2009, 8, 3464-6474.

Saric J, Li JV, Wang Y, Keiser J, Veselkov K, Dirnhofer S, Yap IKS, Nicholson JK, Holmes E, Utzinger J. ‘Panorganismal metabolic response modeling of an experimental Echinostoma caproni infection in the mouse.’ J Proteome Res. 2009, 8, 3899- 3911.

Loo RL, Coen M, Ebbels T, Cloarec O, Maibaum E, Bictash M, Yap I, Elliott P, Stamler J, Nicholson JK, Holmes E; for the INTERMAP Research Group. ‘Metabolic Profiling and Population Screening of Analgesic Usage in Nuclear Magnetic Resonance Spectroscopy-Based Large-Scale Epidemiologic Studies.’ Anal. Chem. 2009, 81, 5119-5129.

Bictash M, Ebbels TM, Chan Q, Loo RL, Yap IKS, Brown IJ, de Iorio M, Daviglus ML, Holmes E, Stamler J, Nicholson JK, Elliott P. ‘Opening up the "Black Box": Metabolic phenotyping and metabolome-wide association studies in epidemiology.’ J. Clin. Epidemiol. 2010 Jan 5. [Epub ahead of print]

Yap IKS, Angley M, Veselkov K, Martin FP, Holmes E, Lindon JC, Nicholson JK. ‘Urinary metabolic phenotyping differentiates children with autism from their unaffected siblings and age-matched controls’ J. Proteome Res. 2010, Status: Accepted.