Contact details
Dr Jim T Crawley
Senior Lecturer
Department of Medicine
5S5a
Commonwealth Building
Hammersmith Campus
Tel: +44 (0)20 8383 2297
Email:
Dr James Crawley
Dr Jim Crawley is a non-clinical senior lecturer in the Department of Haematology.
He graduated from Durham University in with a BSc in Molecular Biology and Biochemistry, and obtained his PhD from Imperial College London in 2001. He joined the Haematology Department in 2002. His research interests include structure/function analyses of various proteins involved in haemostasis, including ADAMTS13, VWF, TFPI, protein C, protein S and EPCR.
Dr Jim Crawley is Scientific Editor for the Journal of Thrombosis & Haemostasis.
Selected Publications
Journals
- Xiang Y; de Groot R; Crawley JT; Lane DA. (12 Jul 2011). Mechanism of von Willebrand factor scissile bond cleavage by a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13). Proc Natl Acad Sci U S A. 108:11602-11607. DOI.
- de Groot R; Lane DA; Crawley JT. (21 Oct 2010). The ADAMTS13 metalloprotease domain: roles of subsites in enzyme activity and specificity. Blood. 116:3064-3072. DOI.
- Luken BM; Winn LY; Emsley J; Lane DA; Crawley JT. (10 Jun 2010). The importance of vicinal cysteines, C1669 and C1670, for von Willebrand factor A2 domain function. Blood. 115:4910-4913. DOI.
- Andersson HM; Arantes MJ; Crawley JT; Luken BM; Tran S; Dahlbäck B; Lane DA; Rezende SM. (10 Jun 2010). Activated protein C cofactor function of protein S: a critical role for Asp95 in the EGF1-like domain. Blood. 115:4878-4885. DOI.
- Pos W; Crawley JT; Fijnheer R; Voorberg J; Lane DA; Luken BM. (25 Feb 2010). An autoantibody epitope comprising residues R660, Y661, and Y665 in the ADAMTS13 spacer domain identifies a binding site for the A2 domain of VWF. Blood. 115:1640-1649. DOI.
- de Groot R; Bardhan A; Ramroop N; Lane DA; Crawley JT. (28 May 2009). Essential role of the disintegrin-like domain in ADAMTS13 function. Blood. 113:5609-5616. DOI.
- Gardner MD; Chion CK; de Groot R; Shah A; Crawley JT; Lane DA. (29 Jan 2009). A functional calcium-binding site in the metalloprotease domain of ADAMTS13. Blood. 113:1149-1157. DOI.
- Chion CK; Doggen CJ; Crawley JT; Lane DA; Rosendaal FR. (1 Mar 2007). ADAMTS13 and von Willebrand factor and the risk of myocardial infarction in men. Blood. 109:1998-2000. DOI.
- Zanardelli S; Crawley JT; Chion CK; Lam JK; Preston RJ; Lane DA. (20 Jan 2006). ADAMTS13 substrate recognition of von Willebrand factor A2 domain. J Biol Chem. 281:1555-1563. DOI.
- Crawley JT; Lam JK; Rance JB; Mollica LR; O'Donnell JS; Lane DA. (1 Feb 2005). Proteolytic inactivation of ADAMTS13 by thrombin and plasmin. Blood. 105:1085-1093. DOI.
