Dr James V Gardiner

Publications


Journals

  • Patterson M; Bloom SR; Gardiner JV. (Nov 2011). Ghrelin and appetite control in humans--potential application in the treatment of obesity. Peptides. 32:2290-2294. DOI.
  • McGowan BM; Minnion JS; Murphy KG; White NE; Roy D; Stanley SA; Dhillo WS; Gardiner JV; et alGhatei MA; Bloom SR. (Dec 2010). Central and peripheral administration of human relaxin-2 to adult male rats inhibits food intake. Diabetes Obes Metab. 12:1090-1096. DOI.
  • Gardiner JV; Beale KE; Roy D; Boughton CK; Bataveljic A; Campbell DC; Bewick GA; Patel NA; et alPatterson M; Leavy EM; Ghatei MA; Bloom SR; Dhillo WS. (1 Oct 2010). Cerebellin1 is a novel orexigenic peptide. DIABETES OBESITY & METABOLISM. 12:883-890. DOI.
  • Boughton CK; Patterson M; Bewick GA; Tadross JA; Gardiner JV; Beale KEL; Chaudery F; Hunter G; et alBusbridge M; Leavy EM; Ghatei MA; Bloom SR; Murphy KG. (1 Oct 2010). Alarin stimulates food intake and gonadotrophin release in male rats. BRITISH JOURNAL OF PHARMACOLOGY. 161:601-613. DOI.
  • Gardiner JV; Campbell D; Patterson M; Kent A; Ghatei MA; Bloom SR; Bewick GA. (Jun 2010). The hyperphagic effect of ghrelin is inhibited in mice by a diet high in fat. Gastroenterology. 138:2468-2476.e1. DOI.
  • Gardiner JV; Bataveljic A; Patel NA; Bewick GA; Roy D; Campbell D; Greenwood HC; Murphy KG; et alHameed S; Jethwa PH; Ebling FJ; Vickers SP; Cheetham S; Ghatei MA; Bloom SR; Dhillo WS. (Feb 2010). Prokineticin 2 is a hypothalamic neuropeptide that potently inhibits food intake. Diabetes. 59:397-406. DOI.
  • Bewick GA; Kent A; Campbell D; Patterson M; Ghatei MA; Bloom SR; Gardiner JV. (1 Apr 2009). Mice With Hyperghrelinemia Are Hyperphagic and Glucose Intolerant and Have Reduced Leptin Sensitivity. DIABETES. 58:840-846. Author weblink DOI.
  • Dhillo WS; Bewick GA; White NE; Gardiner JV; Thompson EL; Bataveljic A; Murphy KG; Roy D; et alPatel NA; Scutt JN; Armstrong A; Ghatei MA; Bloom SR. (1 Mar 2009). The thyroid hormone derivative 3-iodothyronamine increases food intake in rodents. DIABETES OBESITY & METABOLISM. 11:251-260. Author weblink DOI.
  • Smith KL; Gardiner JV; Ward HL; Kong WM; Murphy KG; Martin NM; Ghatei MA; Bloom SR. (1 Oct 2008). Overexpression of CART in the PVN increases food intake and weight gain in rats. OBESITY. 16:2239-2244. Author weblink DOI.
  • McGowan BM; Stanley SA; Donovan J; Thompson EL; Patterson M; Semjonous NM; Gardiner JV; Murphy KG; et alGhatei MA; Bloom SR. (1 Aug 2008). Relaxin-3 stimulates the hypothalamic-pituitary-gonadal axis. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 295:E278-E286. Author weblink DOI.
  • Gardiner JV; Jayasena CN; Bloom SR. (Jun 2008). Gut hormones: a weight off your mind. J Neuroendocrinol. 20:834-841. DOI.
  • Gardiner J; Bloom S. (Mar 2008). Ghrelin gets its GOAT. Cell Metab. 7:193-194. DOI.
  • White NE; Dhillo WS; Liu Y-L; Small CJ; Kennett GA; Gardiner JV; Ghatei MA; Bloom SR. (1 Feb 2008). Co-administration of SR141716 with peptide YY3-36 or oxyntomodulin has additive effects on food intake in mice. DIABETES OBESITY & METABOLISM. 10:167-170. Author weblink DOI.
  • McGowan BM; Stanley SA; White NE; Spangeus A; Patterson M; Thompson EL; Smith KL; Donovan J; et alGardiner JV; Ghatei MA; Bloom SR. (Mar 2007). Hypothalamic mapping of orexigenic action and Fos-like immunoreactivity following relaxin-3 administration in male Wistar rats. Am J Physiol Endocrinol Metab. 292:E913-E919. DOI.
  • McGowan BM; Stanley SA; Smith KL; Minnion JS; Donovan J; Thompson EL; Patterson M; Connolly MM; et alAbbott CR; Small CJ; Gardiner JV; Ghatei MA; Bloom SR. (11 Sep 2006). Effects of acute and chronic relaxin-3 on food intake and energy expenditure in rats. Regul Pept. 136:72-77. DOI Open Access copy.
  • Smith KL; Patterson M; Dhillo WS; Patel SR; Semjonous NM; Gardiner JV; Ghatei MA; Bloom SR. (Jul 2006). Neuropeptide S stimulates the hypothalamo-pituitary-adrenal axis and inhibits food intake. Endocrinology. 147:3510-3518. DOI Open Access copy.
  • Patel AD; Stanley SA; Murphy KG; Frost GS; Gardiner JV; Kent AS; White NE; Ghatei MA; et alBloom SR. (15 Mar 2006). Ghrelin stimulates insulin-induced glucose uptake in adipocytes. Regul Pept. 134:17-22. DOI.
  • le Roux CW; Batterham RL; Aylwin SJ; Patterson M; Borg CM; Wynne KJ; Kent A; Vincent RP; et alGardiner J; Ghatei MA; Bloom SR. (Jan 2006). Attenuated peptide YY release in obese subjects is associated with reduced satiety. Endocrinology. 147:3-8. DOI.
  • Mahmoodi M; Gardiner JV; Karam GRA; Khaksari M; Murphy KG; Ghatei MA; Bloom SR. (15 Dec 2005). Implantation of fibre encapsulated RIN 1056a cells transfected with NPY cDNA into the lateral ventricle of rats alters body weight. REGULATORY PEPTIDES. 132:80-84. Author weblink DOI.
  • Dhillo WS; Gardiner JV; Castle L; Bewick GA; Smith KL; Meeran K; Todd JF; Ghatei MA; et alBloom SR. (Dec 2005). Agouti related protein (AgRP) is upregulated in Cushing's syndrome. Exp Clin Endocrinol Diabetes. 113:602-606. DOI Open Access copy.
  • McGowan BM; Stanley SA; Smith KL; White NE; Connolly MM; Thompson EL; Gardiner JV; Murphy KG; et alGhatei MA; Bloom SR. (Aug 2005). Central relaxin-3 administration causes hyperphagia in male Wistar rats. Endocrinology. 146:3295-3300. DOI Open Access copy.
  • Bewick GA; Dhillo WS; Darch SJ; Murphy KG; Gardiner JV; Jethwa PH; Kong WM; Ghatei MA; et alBloom SR. (Aug 2005). Hypothalamic cocaine- and amphetamine-regulated transcript (CART) and agouti-related protein (AgRP) neurons coexpress the NOP1 receptor and nociceptin alters CART and AgRP release. Endocrinology. 146:3526-3534. DOI.
  • Bewick GA; Gardiner JV; Dhillo WS; Kent AS; White NE; Webster Z; Ghatei MA; Bloom SR. (1 Aug 2005). Postembryonic ablation of AgRP neurons in mice leads to a lean, hypophagic phenotype. FASEB JOURNAL. 19:1680-+. Author weblink DOI.
  • Gardiner JV; Kong WM; Ward H; Murphy KG; Dhillo WS; Bloom SR. (25 Feb 2005). AAV mediated expression of anti-sense neuropeptide Y cRNA in the arcuate nucleus of rats results in decreased weight gain and food intake. Biochem Biophys Res Commun. 327:1088-1093. DOI.
  • Martin NM; Small CJ; Sajedi A; Liao XH; Weiss RE; Gardiner JV; Ghatei MA; Bloom SR. (15 Nov 2004). Abnormalities of the hypothalamo-pituitary-thyroid axis in the pro-opiomelanocortin deficient mouse. Regul Pept. 122:169-172. DOI.
  • Kong WM; Martin NM; Smith KL; Gardiner JV; Connoley IP; Stephens DA; Dhillo WS; Ghatei MA; et alSmall CJ; Bloom SR. (Nov 2004). Triiodothyronine stimulates food intake via the hypothalamic ventromedial nucleus independent of changes in energy expenditure. Endocrinology. 145:5252-5258. DOI Open Access copy.
  • Stanley SA; Murphy KG; Bewick GA; Kong WM; Opacka-Juffry J; Gardiner JV; Ghatei M; Small CJ; et alBloom SR. (Sep 2004). Regulation of rat pituitary cocaine- and amphetamine-regulated transcript (CART) by CRH and glucocorticoids. Am J Physiol Endocrinol Metab. 287:E583-E590. DOI.
  • Mahmoodi M; Gardiner JV; Ghatei MA; Asadikaram G; Bloom SR. (1 Mar 2004). Investigation of the chronic effects of NPY by subcutaneous implantation of 6-23 cells producing NPY in WAG rats. CLINICAL BIOCHEMISTRY. 37:217-223. Author weblink DOI.
  • Seth A; Stanley S; Jethwa P; Gardiner J; Ghatei M; Bloom S. (Feb 2004). Galanin-like peptide stimulates the release of gonadotropin-releasing hormone in vitro and may mediate the effects of leptin on the hypothalamo-pituitary-gonadal axis. Endocrinology. 145:743-750. DOI.
  • Kong WM; Stanley S; Gardiner J; Abbott C; Murphy K; Seth A; Connoley I; Ghatei M; et alStephens D; Bloom S. (Sep 2003). A role for arcuate cocaine and amphetamine-regulated transcript in hyperphagia, thermogenesis, and cold adaptation. FASEB J. 17:1688-1690. DOI.
  • Stanley SA; Davies S; Small CJ; Gardiner JV; Ghatei MA; Smith DM; Bloom SR. (22 May 2003). gamma-MSH increases intracellular cAMP accumulation and GnRH release in vitro and LH release in vivo. FEBS Lett. 543:66-70.
  • Dhillo WS; Small CJ; Jethwa PH; Russell SH; Gardiner JV; Bewick GA; Seth A; Murphy KG; et alGhatei MA; Bloom SR. (Apr 2003). Paraventricular nucleus administration of calcitonin gene-related peptide inhibits food intake and stimulates the hypothalamo-pituitary-adrenal axis. Endocrinology. 144:1420-1425.
  • Ward H; Gardiner J; Kong WM; Murphy K; Bloom S. (Feb 2003). Distribution of fluorescence following injection of recombinant adeno-associated virus encoding green fluorescent protein into the paraventricular nucleus. Neuroendocrinology. 77:100-104. DOI.
  • Dhillo WS; Small CJ; Gardiner JV; Bewick GA; Whitworth EJ; Jethwa PH; Seal LJ; Ghatei MA; et alHinson JP; Bloom SR. (31 Jan 2003). Agouti-related protein has an inhibitory paracrine role in the rat adrenal gland. Biochem Biophys Res Commun. 301:102-107.
  • Goldstone AP; Howard JK; Lord GM; Ghatei MA; Gardiner JV; Wang ZL; Wang RM; Girgis SI; et alBailey CJ; Bloom SR. (12 Jul 2002). Leptin prevents the fall in plasma osteocalcin during starvation in male mice. Biochem Biophys Res Commun. 295:475-481.
  • Bates SH; Gardiner JV; Jones RB; Bloom SR; Bailey CJ. (Mar 2002). Acute stimulation of glucose uptake by leptin in l6 muscle cells. Horm Metab Res. 34:111-115. DOI.
  • Sunter D; Morgan I; Edwards CM; Dakin CL; Murphy KG; Gardiner J; Taheri S; Rayes E; et alBloom SR. (13 Jul 2001). Orexins: effects on behavior and localisation of orexin receptor 2 messenger ribonucleic acid in the rat brainstem. Brain Res. 907:27-34.
  • Taheri S; Gardiner J; Hafizi S; Murphy K; Dakin C; Seal L; Small C; Ghatei M; et alBloom S. (5 Mar 2001). Orexin A immunoreactivity and preproorexin mRNA in the brain of Zucker and WKY rats. Neuroreport. 12:459-464.
  • Murphy KG; Abbott CR; Mahmoudi M; Hunter R; Gardiner JV; Rossi M; Stanley SA; Ghatei MA; et alKuhar MJ; Bloom SR. (Sep 2000). Quantification and synthesis of cocaine- and amphetamine-regulated transcript peptide (79-102)-like immunoreactivity and mRNA in rat tissues. J Endocrinol. 166:659-668.
  • Satoh F; Smith DM; Gardiner JV; Mahmoodi M; Murphy KG; Ghatei MA; Bloom SR. (Apr 2000). Characterization and distribution of prolactin releasing peptide (PrRP) binding sites in the rat--evidence for a novel binding site subtype in cardiac and skeletal muscle. Br J Pharmacol. 129:1787-1793. DOI.
  • Taheri S; Sunter D; Dakin C; Moyes S; Seal L; Gardiner J; Rossi M; Ghatei M; et alBloom S. (28 Jan 2000). Diurnal variation in orexin A immunoreactivity and prepro-orexin mRNA in the rat central nervous system. Neurosci Lett. 279:109-112.
  • Coppock HA; Owji AA; Austin C; Upton PD; Jackson ML; Gardiner JV; Ghatei MA; Bloom SR; et alSmith DM. (15 Feb 1999). Rat-2 fibroblasts express specific adrenomedullin receptors, but not calcitonin-gene-related-peptide receptors, which mediate increased intracellular cAMP and inhibit mitogen-activated protein kinase activity. BIOCHEMICAL JOURNAL. 338:15-22. Author weblink DOI.
  • Kulkarni RN; Wang ZL; Wang RM; Hurley JD; Smith DM; Ghatei MA; Withers DJ; Gardiner JV; et alBailey CJ; Bloom SR. (1 Dec 1997). Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice. J Clin Invest. 100:2729-2736. DOI.
  • Small CJ; Morgan DG; Meeran K; Heath MM; Gunn I; Edwards CM; Gardiner J; Taylor GM; et alHurley JD; Rossi M; Goldstone AP; O'Shea D; Smith DM; Ghatei MA; Bloom SR. (14 Oct 1997). Peptide analogue studies of the hypothalamic neuropeptide Y receptor mediating pituitary adrenocorticotrophic hormone release. Proc Natl Acad Sci U S A. 94:11686-11691.
  • Owji AA; Gardiner JV; Upton PD; Mahmoodi M; Ghatei MA; Bloom SR; Smith DM. (Nov 1996). Characterisation and molecular identification of adrenomedullin binding sites in the rat spinal cord: a comparison with calcitonin gene-related peptide receptors. J Neurochem. 67:2172-2179.
  • Ghatei MA; Takahashi K; Suzuki Y; Gardiner J; Jones PM; Bloom SR. (Jan 1993). Distribution, molecular characterization of pituitary adenylate cyclase-activating polypeptide and its precursor encoding messenger RNA in human and rat tissues. J Endocrinol. 136:159-166.

Conferences

  • Boughton CK; Patterson M; Tadross JA; Bewick GA; Gardiner JV; Ghatei MA; Bloom SR; Murphy KG. The Novel Neuropeptide Alarin Stimulates Food Intake and the Reproductive Axis in Male Rats. 92nd Meeting and Expo of the Endocrine Society (ENDO 2010), 19 Jun 2010 - 22 Jun 2010. 31. ENDOCRINE SOC (1 Jun 2010). Author weblink.
  • Leavy EM; Gardiner JV; Richardson E; Buckley NW; Martin NM; Bloom SR; Smith KL. The Role of Neuropeptide Y within the Hypothalamic Dorsomedial Nucleus in the Regulation of Energy Homeostasis. 92nd Meeting and Expo of the Endocrine Society (ENDO 2010), 19 Jun 2010 - 22 Jun 2010. 31. ENDOCRINE SOC (1 Jun 2010). Author weblink.
  • Richardson E; Hussain SS; Counsell JR; Leavy E; Bewick GA; Bloom SR; Gardiner JV. The Role of Ventromedial Hypothalamic Glucose-Sensing Neurons during Glucoprivation. 92nd Meeting and Expo of the Endocrine Society (ENDO 2010), 19 Jun 2010 - 22 Jun 2010. 31. ENDOCRINE SOC (1 Jun 2010). Author weblink.
  • GHATEI MA; TAKAHASHI K; SUZUKI H; GARDINER JV; JONES PM; BLOOM SR. DISTRIBUTION, SYNTHESIS AND MOLECULAR CHARACTERIZATION OF PITUITARY ADENYLATE-CYCLASE ACTIVATING POLYPEPTIDE (PACAP) IN RAT-BRAIN. 5TH INTERNATIONAL SYMP ON VIP ( VASOACTIVE INTESTINAL PEPTIDE ) AND RELATED PEPTIDES. 13:337-342. (Feb 1992).
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