Professor Jeremy Saklatvala

Publications


Journals

  • Joanny E; Ding Q; Gong L; Kong P; Saklatvala J; Clark AR. (Feb 2012). Anti-inflammatory effects of selective glucocorticoid receptor modulators are partially dependent on up-regulation of dual specificity phosphatase 1. Br J Pharmacol. 165:1124-1136. DOI.
  • Marchese FP; Aubareda A; Tudor C; Saklatvala J; Clark AR; Dean JL. (Jul 2001). MAPKAP kinase 2 blocks tristetraprolin-directed mRNA decay by inhibiting CAF1 deadenylase recruitment. J Biol Chem. Epub ahead of print.
  • Tchen CR; Martins JR; Paktiawal N; Perelli R; Saklatvala J; Clark AR. (22 Jan 2010). Glucocorticoid regulation of mouse and human dual specificity phosphatase 1 (DUSP1) genes: unusual cis-acting elements and unexpected evolutionary divergence. J Biol Chem. 285:2642-2652. DOI.
  • Clark AR; Dean JL; Saklatvala J. (Nov 2009). The p38 MAPK pathway mediates both antiinflammatory and proinflammatory processes: comment on the article by Damjanov and the editorial by Genovese. Arthritis Rheum. 60:3513-3514. DOI.
  • Tudor C; Marchese FP; Hitti E; Aubareda A; Rawlinson L; Gaestel M; Blackshear PJ; Clark AR; et alSaklatvala J; Dean JLE. (18 Jun 2009). The p38 MAPK pathway inhibits tristetraprolin-directed decay of interleukin-10 and pro-inflammatory mediator mRNAs in murine macrophages. FEBS LETTERS. 583:1933-1938. Author weblink DOI.
  • Chia SL; Sawaji Y; Burleigh A; McLean C; Inglis J; Saklatvala J; Vincent T. (Jul 2009). Fibroblast growth factor 2 is an intrinsic chondroprotective agent that suppresses ADAMTS-5 and delays cartilage degradation in murine osteoarthritis. Arthritis Rheum. 60:2019-2027. DOI.
  • Clark A; Dean J; Tudor C; Saklatvala J. (1 Jan 2009). Post-transcriptional gene regulation by MAP kinases via AU-rich elements. FRONTIERS IN BIOSCIENCE. 14:847-871. Author weblink DOI.
  • Sawaji Y; Hynes J; Vincent T; Saklatvala J. (Nov 2008). Fibroblast growth factor 2 inhibits induction of aggrecanase activity in human articular cartilage. Arthritis Rheum. 58:3498-3509. DOI.
  • Wait R; Peirce M; Brook M; Wu X; Begum S; Saklatvala J; Cope A. (1 Aug 2005). Detection of novel tyrosine-phosphorylated proteins in macrophages by proteomic analysis. MOLECULAR & CELLULAR PROTEOMICS. 4:S283-S283. Author weblink.
  • Vincent TL; Saklatvala J. (1 May 2008). Is the response of cartilage to injury relevant to osteoarthritis?. ARTHRITIS AND RHEUMATISM. 58:1207-1210. Author weblink DOI.
  • Hermansson M; Saklatvala J; Wait R. (2007). Two-dimensional electrophoresis of proteins secreted from articular cartilage. Methods Mol Med. 136:349-359.
  • Peirce MJ; Saklatvala J; Cope AP; Wait R. (2007). Mapping lymphocyte plasma membrane proteins: a proteomic approach. Methods Mol Med. 136:361-367.
  • Alexander S; Watt F; Sawaji Y; Hermansson M; Saklatvala J. (Nov 2007). Activin A is an anticatabolic autocrine cytokine in articular cartilage whose production is controlled by fibroblast growth factor 2 and NF-kappaB. Arthritis Rheum. 56:3715-3725. DOI.
  • Brikos C; Wait R; Begum S; O'Neill LAJ; Saklatvala J. (1 Sep 2007). Mass spectrometric analysis of the endogenous type I interleukin-1 (IL-1) receptor signaling complex formed after IL-1 binding identifies IL-1RAcP, MyD88, and IRAK-4 as the stable components. MOLECULAR & CELLULAR PROTEOMICS. 6:1551-1559. Author weblink DOI.
  • Nagase H; Brew K. (2003). DesigningTIMP (tissue inhibitor of metalloproteinases variants that are selective metalloproteinase inhibitors. BIOCHEM SOC SYMP. 70:201-212.
  • Vincent TL; McLean CJ; Full LE; Peston D; Saklatvala J. (Jul 2007). FGF-2 is bound to perlecan in the pericellular matrix of articular cartilage, where it acts as a chondrocyte mechanotransducer. Osteoarthritis Cartilage. 15:752-763. DOI.
  • Saklatvala J. (Feb 2007). Inflammatory signaling in cartilage: MAPK and NF-kappaB pathways in chondrocytes and the use of inhibitors for research into pathogenesis and therapy of osteoarthritis. Curr Drug Targets. 8:305-313.
  • Alford KA; Glennie S; Turrell BR; Rawlinson L; Saklatvala J; Dean JL. (2 Mar 2007). Heat shock protein 27 functions in inflammatory gene expression and transforming growth factor-beta-activated kinase-1 (TAK1)-mediated signaling. J Biol Chem. 282:6232-6241. DOI.
  • Vincent TL; Hermansson MA; Hansen UN; Amis AA; Saklatvala J. (Feb 2004). Basic fibroblast growth factor mediates transduction of mechanical signals when articular cartilage is loaded. Arthritis Rheum. 50:526-533. DOI.
  • Catterall JB; Rowan AD; Sarsfield S; Saklatvala J; Wait R; Cawston TE. (1 Sep 2006). Development of a novel 2D proteomics approach for the identification of proteins secreted by primary chondrocytes after stimulation by IL-1 and oncostatin M. RHEUMATOLOGY. 45:1101-1109. Author weblink DOI.
  • Abraham SM; Lawrence T; Kleiman A; Warden P; Medghalchi M; Tuckermann J; Saklatvala J; Clark AR. (7 Aug 2006). Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1. J Exp Med. 203:1883-1889. DOI.
  • Vincent T; Saklatvala J. (Jun 2006). Basic fibroblast growth factor: an extracellular mechanotransducer in articular cartilage?. Biochem Soc Trans. 34:456-457. DOI.
  • Brook M; Tchen CR; Santalucia T; McIlrath J; Arthur JS; Saklatvala J; Clark AR. (Mar 2006). Posttranslational regulation of tristetraprolin subcellular localization and protein stability by p38 mitogen-activated protein kinase and extracellular signal-regulated kinase pathways. Mol Cell Biol. 26:2408-2418. DOI.
  • Peirce MJ; Begum S; Saklatvala J; Cope AP; Wait R. (Jun 2005). Two-stage affinity purification for inducibly phosphorylated membrane proteins. Proteomics. 5:2417-2421. DOI.
  • Dean JLE; Wait R; Mahtani KR; Sully G; Clark AR; Saklatvala J. (1 Apr 2005). The 3' untranslated region of tumor necrosis factor alpha mRNA is a target of the mRNA-stabilizing factor HuR (vol 21, pg 721, 2001). MOLECULAR AND CELLULAR BIOLOGY. 25:3400-3400. Author weblink DOI.
  • Hermansson M; Sawaji Y; Bolton M; Alexander S; Wallace A; Begum S; Wait R; Saklatvala J. (15 Oct 2004). Proteomic analysis of articular cartilage shows increased type II collagen synthesis in osteoarthritis and expression of inhibin betaA (activin A), a regulatory molecule for chondrocytes. J Biol Chem. 279:43514-43521. DOI.
  • Dean JL; Sully G; Clark AR; Saklatvala J. (Oct 2004). The involvement of AU-rich element-binding proteins in p38 mitogen-activated protein kinase pathway-mediated mRNA stabilisation. Cell Signal. 16:1113-1121. DOI.
  • Gruber J; Vincent TL; Hermansson M; Bolton M; Wait R; Saklatvala J. (Aug 2004). Induction of interleukin-1 in articular cartilage by explantation and cutting. Arthritis Rheum. 50:2539-2546. DOI.
  • Saklatvala J. (Aug 2004). The p38 MAP kinase pathway as a therapeutic target in inflammatory disease. Curr Opin Pharmacol. 4:372-377. DOI.
  • Tchen CR; Brook M; Saklatvala J; Clark AR. (30 Jul 2004). The stability of tristetraprolin mRNA is regulated by mitogen-activated protein kinase p38 and by tristetraprolin itself. J Biol Chem. 279:32393-32400. DOI.
  • Vincent TL; Hermansson MA; Hansen UN; Amis AA; Saklatvala J. (1 Feb 2004). Basic fibroblast growth factor mediates transduction of mechanical signals when articular cartilage is loaded. ARTHRITIS AND RHEUMATISM. 50:526-533. Author weblink DOI.
  • Sully G; Dean JL; Wait R; Rawlinson L; Santalucia T; Saklatvala J; Clark AR. (1 Feb 2004). Structural and functional dissection of a conserved destabilizing element of cyclo-oxygenase-2 mRNA: evidence against the involvement of AUF-1 [AU-rich element/poly(U)-binding/degradation factor-1], AUF-2, tristetraprolin, HuR (Hu antigen R) or FBP1 (far-upstream-sequence-element-binding protein 1). Biochem J. 377:629-639. DOI.
  • Peirce MJ; Wait R; Begum S; Saklatvala J; Cope AP. (Jan 2004). Expression profiling of lymphocyte plasma membrane proteins. Mol Cell Proteomics. 3:56-65. DOI.
  • Saklatvala J; Nagase H. (2004). Report on the Molecular Approaches to Osteoarthritis Symposium, Imperial College London, UK, 18-20 April 2004. Arthritis Res Ther. 6:203-207. DOI.
  • Dean JL; Sarsfield SJ; Tsounakou E; Saklatvala J. (10 Oct 2003). p38 Mitogen-activated protein kinase stabilizes mRNAs that contain cyclooxygenase-2 and tumor necrosis factor AU-rich elements by inhibiting deadenylation. J Biol Chem. 278:39470-39476. DOI.
  • Clark AR; Dean JL; Saklatvala J. (3 Jul 2003). Post-transcriptional regulation of gene expression by mitogen-activated protein kinase p38. FEBS Lett. 546:37-44.
  • Saklatvala J; Nagase H; Salvesen G. (2003). A tribute to Alan J. Barrett. Biochem Soc Symp. ix-x.
  • Saklatvala J; Dean J; Clark A. Saklatvala J (ed); Nagase H (ed); Salvesen G (ed). (1 Jan 2003). Control of the expression of inflammatory response genes. PROTEASES AND THE REGULATION OF BIOLOGICAL PROCESSES. 70:95-106. Author weblink.
  • Kracht M; Saklatvala J. (7 Nov 2002). Transcriptional and post-transcriptional control of gene expression in inflammation. Cytokine. 20:91-106.
  • Lasa M; Abraham SM; Boucheron C; Saklatvala J; Clark AR. (Nov 2002). Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38. Mol Cell Biol. 22:7802-7811.
  • Dean JL; Sully G; Wait R; Rawlinson L; Clark AR; Saklatvala J. (15 Sep 2002). Identification of a novel AU-rich-element-binding protein which is related to AUF1. Biochem J. 366:709-719. DOI.
  • Vincent T; Hermansson M; Bolton M; Wait R; Saklatvala J. (11 Jun 2002). Basic FGF mediates an immediate response of articular cartilage to mechanical injury. Proc Natl Acad Sci U S A. 99:8259-8264. DOI.
  • Saklatvala J. (2002). Glucocorticoids: do we know how they work?. Arthritis Res. 4:146-150.
  • Mahtani KR; Brook M; Dean JL; Sully G; Saklatvala J; Clark AR. (Oct 2001). Mitogen-activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stability. Mol Cell Biol. 21:6461-6469.
  • Lasa M; Brook M; Saklatvala J; Clark AR. (Feb 2001). Dexamethasone destabilizes cyclooxygenase 2 mRNA by inhibiting mitogen-activated protein kinase p38. Mol Cell Biol. 21:771-780. DOI.
  • Dean JL; Wait R; Mahtani KR; Sully G; Clark AR; Saklatvala J. (Feb 2001). The 3' untranslated region of tumor necrosis factor alpha mRNA is a target of the mRNA-stabilizing factor HuR. Mol Cell Biol. 21:721-730. DOI.
  • Finch A; Davis W; Carter WG; Saklatvala J. (15 Jan 2001). Analysis of mitogen-activated protein kinase pathways used by interleukin 1 in tissues in vivo: activation of hepatic c-Jun N-terminal kinases 1 and 2, and mitogen-activated protein kinase kinases 4 and 7. Biochem J. 353:275-281.
  • Brook M; Sully G; Clark AR; Saklatvala J. (13 Oct 2000). Regulation of tumour necrosis factor alpha mRNA stability by the mitogen-activated protein kinase p38 signalling cascade. FEBS Lett. 483:57-61.
  • Lasa M; Mahtani KR; Finch A; Brewer G; Saklatvala J; Clark AR. (Jun 2000). Regulation of cyclooxygenase 2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascade. Mol Cell Biol. 20:4265-4274.
  • Cockerill GW; Saklatvala J; Ridley SH; Yarwood H; Miller NE; Oral B; Nithyanathan S; Taylor G; et alHaskard DO. (Apr 1999). High-density lipoproteins differentially modulate cytokine-induced expression of E-selectin and cyclooxygenase-2. Arterioscler Thromb Vasc Biol. 19:910-917.
  • Davis W; Stephens LR; Hawkins PT; Saklatvala J. (1 Mar 1999). Synergistic activation of JNK/SAPK by interleukin-1 and platelet-derived growth factor is independent of Rac and Cdc42. Biochem J. 338 ( Pt 2):387-392.
  • Bell MC; Carroll GJ; Chapman HM; Mills JN; Layton MJ; Saklatvala J. (1 Feb 1999). The proinflammatory and chondral activities of leukemia inhibitory factor in goat joints are partially a function of interleukin-1. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH. 19:197-208. Author weblink DOI.
  • Dean JL; Brook M; Clark AR; Saklatvala J. (1 Jan 1999). p38 mitogen-activated protein kinase regulates cyclooxygenase-2 mRNA stability and transcription in lipopolysaccharide-treated human monocytes. J Biol Chem. 274:264-269.
  • Saklatvala J; Dean J; Finch A. (1999). Protein kinase cascades in intracellular signalling by interleukin-I and tumour necrosis factor. Biochem Soc Symp. 64:63-77.
  • Ridley SH; Dean JL; Sarsfield SJ; Brook M; Clark AR; Saklatvala J. (13 Nov 1998). A p38 MAP kinase inhibitor regulates stability of interleukin-1-induced cyclooxygenase-2 mRNA. FEBS Lett. 439:75-80.
  • Stylianou E; Saklatvala J. (Oct 1998). Interleukin-1. Int J Biochem Cell Biol. 30:1075-1079.
  • Craxton A; Shu G; Graves JD; Saklatvala J; Krebs EG; Clark EA. (1 Oct 1998). p38 MAPK is required for CD40-induced gene expression and proliferation in B lymphocytes. J Immunol. 161:3225-3236.
  • Krause A; Holtmann H; Eickemeier S; Winzen R; Szamel M; Resch K; Saklatvala J; Kracht M. (11 Sep 1998). Stress-activated protein kinase/Jun N-terminal kinase is required for interleukin (IL)-1-induced IL-6 and IL-8 gene expression in the human epidermal carcinoma cell line KB. J Biol Chem. 273:23681-23689.
  • Guesdon F; Knight CG; Rawlinson LM; Saklatvala J. (28 Nov 1997). Dual specificity of the interleukin 1- and tumor necrosis factor-activated beta casein kinase. J Biol Chem. 272:30017-30024.
  • Finch A; Holland P; Cooper J; Saklatvala J; Kracht M. (24 Nov 1997). Selective activation of JNK/SAPK by interleukin-1 in rabbit liver is mediated by MKK7. FEBS Lett. 418:144-148.
  • Barros LF; Young M; Saklatvala J; Baldwin SA. (1 Nov 1997). Evidence of two mechanisms for the activation of the glucose transporter GLUT1 by anisomycin: p38(MAP kinase) activation and protein synthesis inhibition in mammalian cells. J Physiol. 504 ( Pt 3):517-525.
  • Baldwin SA; Barros LF; Griffiths M; Ingram J; Robbins EC; Streets AJ; Saklatvala J. (Aug 1997). Regulation of GLUT1 in response to cellular stress. Biochem Soc Trans. 25:954-958.
  • Guesdon F; Waller RJ; Saklatvala J. (Jul 1997). Specific detection of an interleukin 1- and tumour necrosis factor-activated beta-casein kinase in HeLa and KB cells. Cytokine. 9:471-479.
  • Crawley JB; Rawlinson L; Lali FV; Page TH; Saklatvala J; Foxwell BM. (6 Jun 1997). T cell proliferation in response to interleukins 2 and 7 requires p38MAP kinase activation. J Biol Chem. 272:15023-15027.
  • Ridley SH; Sarsfield SJ; Lee JC; Bigg HF; Cawston TE; Taylor DJ; DeWitt DL; Saklatvala J. (1 Apr 1997). Actions of IL-1 are selectively controlled by p38 mitogen-activated protein kinase: regulation of prostaglandin H synthase-2, metalloproteinases, and IL-6 at different levels. J Immunol. 158:3165-3173.
  • Graves JD; Draves KE; Craxton A; Saklatvala J; Krebs EG; Clark EA. (26 Nov 1996). Involvement of stress-activated protein kinase and p38 mitogen-activated protein kinase in mIgM-induced apoptosis of human B lymphocytes. Proc Natl Acad Sci U S A. 93:13814-13818.
  • Uciechowski P; Saklatvala J; von der Ohe J; Resch K; Szamel M; Kracht M. (7 Oct 1996). Interleukin 1 activates jun N-terminal kinases JNK1 and JNK2 but not extracellular regulated MAP kinase (ERK) in human glomerular mesangial cells. FEBS Lett. 394:273-278.
  • Saklatvala J; Rawlinson L; Waller RJ; Sarsfield S; Lee JC; Morton LF; Barnes MJ; Farndale RW. (22 Mar 1996). Role for p38 mitogen-activated protein kinase in platelet aggregation caused by collagen or a thromboxane analogue. J Biol Chem. 271:6586-6589.
  • Saklatvala J; Stephens L; Rozengurt E; Karin M. (29 Feb 1996). A heterotrimeric GTPase-regulated isoform of PI3K and the regulation of its potential effectors - Discussion. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES. 351:215-215. Author weblink.

Chapters in books

  • Feldmann M; Saklatvala J. Proinflammatory cytokines. 291-305. (2001).

Conferences

  • Rzeczkowski K; Holzberg D; Kettner-Buhrow D; Beuerlein K; Mueller H; Wolter S; Thiefes A; Doerrie A; et alWait R; Saklatvala J; Kracht M. A novel JNK-regulated ribonucleoprotein complex that responds to cytokines and participates in inflammatory gene expression. 50th Annual Meeting of the Deutsche-Gesellschaft-fur-Experimentelle-und-Klinische-Pharmakologie-und-Toxikologie, 10 Mar 2009 - 12 Mar 2009. 379:39-39. SPRINGER (1 Apr 2009). Author weblink.
  • Watt F; Didangelos A; Peirce M; Wait R; Saklatvala J. INTRACELLULAR SIGNALLING IN RESPONSE TO WOUNDING OF CONNECTIVE TISSUES. Annual Meeting of the British-Society-of-Rheumatology, 28 Apr 2009 - 1 May 2009. 48:I9-I9. OXFORD UNIV PRESS (1 Apr 2009). Author weblink.
  • Sawaji Y; Hynes J; Saklatvala J. Dexamethasone inhibits aggrecanolysis in human articular cartilage but promotes it in porcine tissue. Annual General Meeting of the British-Society-for-Matrix-Biology, 7 Apr 2008 - 8 Apr 2008. 90:A80-A80. WILEY-BLACKWELL PUBLISHING, INC (1 Feb 2009). Author weblink.
  • Sawaji Y; Vincent T; Saklatvala J. Anti-catabolic effect of fibroblast growth factor-2 in human articular cartilage. Annual General Meeting of the British-Society-for-Matrix-Biology, 7 Apr 2008 - 8 Apr 2008. 90:A78-A78. WILEY-BLACKWELL PUBLISHING, INC (1 Feb 2009). Author weblink.
  • Watt F; Sawaji Y; Alexander S; Hermansson M; Saklatvala J. Activin A is an anti-catabolic cytokine produced by injured cartilage via release of fibroblast growth factor-2 and activation of nuclear factor kappa B. Annual General Meeting of the British-Society-for-Matrix-Biology, 7 Apr 2008 - 8 Apr 2008. 90:A77-A77. WILEY-BLACKWELL PUBLISHING, INC (1 Feb 2009). Author weblink.
  • Chia S-L; Sawaji Y; Burleigh A; McLean C; Saklatvala J; Vincent T. A chondroprotective role for matrix-bound FGF2. Annual General Meeting of the British-Society-for-Matrix-Biology, 7 Apr 2008 - 8 Apr 2008. 90:A75-A76. WILEY-BLACKWELL PUBLISHING, INC (1 Feb 2009). Author weblink.
  • McLean C; Sawaji Y; Hermansson M; Saklatvala J; Vincent T. Regulation of secretion of connective tissue growth factor (CTGF) by heparin. Annual General Meeting of the British-Society-for-Matrix-Biology, 7 Apr 2008 - 8 Apr 2008. 90:A59-A60. WILEY-BLACKWELL PUBLISHING, INC (1 Feb 2009). Author weblink.
  • Didangelos A; Sawaji Y; Wait R; Saklatvala J. Apolipoprotein A-1 is a novel inducer of aggrecan breakdown in cultured articular cartilage. Annual General Meeting of the British-Society-for-Matrix-Biology, 7 Apr 2008 - 8 Apr 2008. 90:A59-A59. WILEY-BLACKWELL PUBLISHING, INC (1 Feb 2009). Author weblink.
  • Saklatvala J. The possible interplay of mechanical and molecular factors in cartilage degeneration in osteoarthritis. Annual General Meeting of the British-Society-for-Matrix-Biology, 7 Apr 2008 - 8 Apr 2008. 90:A48-A49. WILEY-BLACKWELL PUBLISHING, INC (1 Feb 2009). Author weblink.
  • Watt F; Alexander S; Sawaji Y; Hermansson M; Saklatvala J. Activin is an anti-catabolic cytokine produced by injured cartilage via release of fibroblast growth factor-2 and activation of nuclear factor kappa B. Annual Meeting of the British-Society-Rheumatology/Spring Meeting of British Health Professional in Rheumatology, 22 Apr 2008 - 25 Apr 2008. 47:II177-II177. OXFORD UNIV PRESS (1 Apr 2008). Author weblink.
  • Chia SL; Inglis J; Essex D; Saklatvala J; Vincent TL. Accelerated disease in a surgical model of murine OA in mice lacking FGF-2. Annual Meeting of the British-Society-of-Rheumatology. 46:I13-I13. (Apr 2007).
  • Peirce MJ; Wait R; Wu X; Begum S; Saklatvala J; Cope AP. Proteomic characterisation of cell contact-dependent macrophage activation. 25th European Workshop for Rheumatology Research. 7:S29-S29. (Feb 2005).
  • Watt FE; Didangelos A; Sawaji Y; Saklatvala J. Sharp injury to articular cartilage activates JNK and NF kappa B and induces expression of inflammatory response genes. BSR Annual Meeting/BHPR Spring Meeting. 45:I82-I82. (Apr 2006).
  • Tudor C; Hitti E; Blackshear PJ; Clark AR; Saklatvala J; Dean JLE. Identification of target mRNAs regulated by both p38 MAPK and tristetraprolin in murine macrophages. Annual Congress of the British-Society-of-Immunology. 120:16-16. (Mar 2007).
Share this on Delicious
Tweet this
Digg this
Stumble this
Share this on Facebook