All Publications

Journals

• Kooner, J; Chambers J; Aguilar-Salinas C; Hinds D; Hyde C; Warnes G; Gomez-Perez F; Frazer K; et al. (2007). Genome-wide scan indetifies variation in MLXIPL associated with plasma triglycerides. Nature Genetics.
• Seth A; Steel JH; Nichol D; Pocock V; Kumaran MK; Fritah A; Mobberley M; Ryder TA; et al. (5 Sep 2007). The Transcriptional Corepressor RIP140 Regulates Oxidative Metabolism in Skeletal Muscle. Cell Metabolism. 6:236-245. Publisher weblink Author weblink.
• Toye AA; Dumas ME; Blancher C; Rothwell AR; Fearnside JF; Wilder SP; Bihoreau MT; Cloarec O; et al. (Sep 2007). Subtle metabolic and liver gene transcriptional changes underlie diet-induced fatty liver susceptibility in insulin-resistant mice. DIABETOLOGIA. 50:1867-1879. DOI.
• Parry S; Ledger V; Tissot B; Haslam SM; Scott J; Morris HR; Dell A. (Jun 2007). Integrated mass spectrometric strategy for characterizing the glycans from glycosphingolipids and glycoproteins: direct identification of sialyl Le(x) in mice. GLYCOBIOLOGY. 17:646-654. DOI.
• Dumas ME; Wilder SP; Bihoreau MT; Barton RH; Fearnside JF; Argoud K; D'Amato L; Wallis RH; et al. (May 2007). Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models. Nat Genet. 39:666-672. DOI.
• Griffin JL; Scott J; Nicholson JK. (Jan 2007). The influence of pharmacogenetics on fatty liver disease in the wistar and kyoto rats: a combined transcriptomic and metabonomic study. J Proteome Res. 6:54-61. DOI.
• Dumas ME; Barton RH; Toye A; Cloarec O; Blancher C; Rothwell A; Fearnside J; Tatoud R; et al. (15 Aug 2006). Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice. Proc Natl Acad Sci U S A. 103:12511-12516. DOI.
• Scott J. (Jun 2004). Pathophysiology and biochemistry of cardiovascular disease. Curr Opin Genet Dev. 14:271-279. DOI.
• Griffin JL; Bonney SA; Mann C; Hebbachi AM; Gibbons GF; Nicholson JK; Shoulders CC; Scott J. (13 Apr 2004). An integrated reverse functional genomic and metabolic approach to understanding orotic acid-induced fatty liver. Physiol Genomics. 17:140-149. DOI.
• Eichenbaum-Voline S; Olivier M; Jones EL; Naoumova RP; Jones B; Gau B; Patel HN; Seed M; et al. (Jan 2004). Linkage and association between distinct variants of the APOA1/C3/A4/A5 gene cluster and familial combined hyperlipidemia. Arterioscler Thromb Vasc Biol. 24:167-174. DOI.
• Naoumova RP; Bonney SA; Eichenbaum-Voline S; Patel HN; Jones B; Jones EL; Amey J; Colilla S; et al. (1 Nov 2003). Confirmed locus on chromosome 11p and candidate loci on 6q and 8p for the triglyceride and cholesterol traits of combined hyperlipidemia. Arterioscler Thromb Vasc Biol. 23:2070-2077. DOI.
• Chester A; Somasekaram A; Tzimina M; Jarmuz A; Gisbourne J; O'Keefe R; Scott J; Navaratnam N. (1 Aug 2003). The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense-mediated decay. EMBO J. 22:3971-3982. DOI.
• Jones B; Jones EL; Bonney SA; Patel HN; Mensenkamp AR; Eichenbaum-Voline S; Rudling M; Myrdal U; et al. (May 2003). Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders. Nat Genet. 34:29-31. DOI.
• Scott J. (Apr 2003). ATVB in focus - Lipoproteins, inflammation, and atherosclerosis. ARTERIOSCL THROM VAS. 23:528-528. DOI.
• Wallace CA; Ali S; Glazier AM; Norsworthy PJ; Carlos DC; Scott J; Freeman TC; Stanton LW; et al. (Apr 2002). Radiation hybrid mapping of 70 rat genes from a data set of differentially expressed genes. Mamm Genome. 13:194-197. DOI.
• Jarmuz A; Chester A; Bayliss J; Gisbourne J; Dunham I; Scott J; Navaratnam N. (Mar 2002). An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22. Genomics. 79:285-296. DOI.
• Glazier AM; Scott J; Aitman TJ. (Feb 2002). Molecular basis of the Cd36 chromosomal deletion underlying SHR defects in insulin action and fatty acid metabolism. Mamm Genome. 13:108-113. DOI.
• Scott J. (2002). The pathogenesis of atherosclerosis and new opportunities for treatment and prevention. J Neural Transm Suppl. 1-17.
• Griffin JL; Mann CJ; Scott J; Shoulders CC; Nicholson JK. (7 Dec 2001). Choline containing metabolites during cell transfection: an insight into magnetic resonance spectroscopy detectable changes. FEBS Lett. 509:263-266.
• Blanc V; Navaratnam N; Henderson JO; Anant S; Kennedy S; Jarmuz A; Scott J; Davidson NO. (30 Mar 2001). (O)over-cap vertical bar identification of GRY-RBP as an apolipoprotein B RNA-binding protein that interacts with both apobec-1 and apobec-1 complementation factor to modulate C to U editing. J BIOL CHEM. 276:10272-10283.
• Chester A; Scott J; Anant S; Navaratnam N. (15 Nov 2000). RNA editing: cytidine to uridine conversion in apolipoprotein B mRNA. Biochim Biophys Acta. 1494:1-13.
• Read J; Anderson TA; Ritchie PJ; Vanloo B; Amey J; Levitt D; Rosseneu M; Scott J; et al. (29 Sep 2000). A mechanism of membrane neutral lipid acquisition by the microsomal triglyceride transfer protein. J Biol Chem. 275:30372-30377. DOI.
• Scott J; Shoulders C; Navaratnam N; Aitman T. (Aug 2000). The genetics of the metabolic overlap syndrome. Proc Nutr Soc. 59:439.
• Scott J. (26 Aug 1999). Heart disease - Good cholesterol news. NATURE. 400:816-+.
• Fujino T; Navaratnam N; Jarmuz A; von Haeseler A; Scott J. (1 Jul 1999). C -> U editing of apolipoprotein B mRNA in marsupials: identification and characterisation of APOBEC-1 from the American opossum Monodelphus domestica. NUCLEIC ACIDS RES. 27:2662-2671.
• Scott J; Navaratnam N; Carter C. (Jul 1999). Molecular modelling of the biosynthesis of the RNA-editing enzyme APOBEC-1, responsible for generating the alternative forms of apolipoprotein B. Exp Physiol. 84:791-800.
• Ritchie PJ; Decout A; Amey J; Mann CJ; Read J; Rosseneu M; Scott J; Shoulders CC. (1 Mar 1999). Baculovirus expression and biochemical characterization of the human microsomal triglyceride transfer protein. Biochem J. 338 ( Pt 2):305-310.
• Nicodeme E; Benoist F; McLeod R; Yao ZM; Scott J; Shoulders CC; Grand-Perret T. (22 Jan 1999). Identification of domains in apolipoprotein B100 that confer a high requirement for the microsomal triglyceride transfer protein. J BIOL CHEM. 274:1986-1993.
• Aitman TJ; Glazier AM; Wallace CA; Cooper LD; Norsworthy PJ; Wahid FN; Al-Majali KM; Trembling PM; et al. (Jan 1999). Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats. Nat Genet. 21:76-83. DOI.
• Scott J; Navaratnam N; Carter C. (Dec 1998). Molecular modelling and the biosynthesis of apolipoprotein B containing lipoproteins. ATHEROSCLEROSIS. 141:S17-S24.
• Richardson N; Navaratnam N; Scott J. (27 Nov 1998). Secondary structure for the apolipoprotein B mRNA editing site. Au-binding proteins interact with a stem loop. J Biol Chem. 273:31707-31717.
• Kooner JS; Baliga RR; Wilding J; Crook D; Packard CJ; Banks LM; Peart S; Aitman TJ; et al. (Jul 1998). Abdominal obesity, impaired nonesterified fatty acid suppression, and insulin-mediated glucose disposal are early metabolic abnormalities in families with premature myocardial infarction. Arterioscler Thromb Vasc Biol. 18:1021-1026.
• Navaratnam N; Fujino T; Bayliss J; Jarmuz A; How A; Richardson N; Somasekaram A; Bhattacharya S; et al. (30 Jan 1998). Escherichia coli cytidine deaminase provides a molecular model for ApoB RNA editing and a mechanism for RNA substrate recognition. J MOL BIOL. 275:695-714.
• Fujino T; Navaratnam N; Scott J. (15 Jan 1998). Human apolipoprotein B RNA editing deaminase gene (APOBEC1). Genomics. 47:266-275. DOI.
• Shovlin CL; Hughes JMB; Scott J; Seidman CE; Seidman JG. (Jul 1997). Characterization of endoglin and identification of novel mutations in hereditary hemorrhagic telangiectasia. AM J HUM GENET. 61:68-79.
• Aitman TJ; Gotoda T; Evans AL; Imrie H; Heath KE; Trembling PM; Truman H; Wallace CA; et al. (Jun 1997). Quantitative trait loci for cellular defects in glucose and fatty acid metabolism in hypertensive rats. Nat Genet. 16:197-201. DOI.
• Thompson GR; Scott J; Walport MJ; Oakley CM; Hughes JMB; Bulpitt CJ; TaylorRobinson SD. (5 Apr 1997). Grand rounds - Hammersmith Hospital - Hazards of running a marathon - Creatine kinase MB can be raised without myocardial infarction. BRIT MED J. 314:1023-1025.
• Morrison JR; Paszty C; Stevens ME; Hughes SD; Forte T; Scott J; Rubin EM. (9 Jul 1996). Apolipoprotein B RNA editing enzyme-deficient mice are viable despite alterations in lipoprotein metabolism. P NATL ACAD SCI USA. 93:7154-7159.
• Baliga R; Lammertsma A; Rhodes C; Aitman T; Scott J; Kooner JS. (May 1996). Positron emission tomography localises insulin resistance to skeletal muscle in premature coronary heart disease. HEART. 75:48-48.
• Hughes SD; Rouy D; Navaratnam N; Scott J; Rubin EM. (Jan 1996). Gene transfer of cytidine deaminase apoBEC-1 lowers lipoprotein(a) in transgenic mice and induces apolipoprotein B editing in rabbits. HUM GENE THER. 7:39-49.
• NARCISI TME; SHOULDERS CC; CHESTER SA; READ J; BRETT DJ; HARRISON GB; GRANTHAM TT; FOX MF; et al. (Dec 1995). MUTATIONS OF THE MICROSOMAL TRIGLYCERIDE-TRANSFER-PROTEIN GENE IN ABETALIPOPROTEINEMIA. AM J HUM GENET. 57:1298-1310.
• KOONER JS; BALIGA RR; WILDING J; PEART S; AITMAN TJ; SCOTT J. (15 Oct 1995). METABOLIC PHENOTYPES FOR GENETIC-ANALYSIS IN CORONARY HEART-DISEASE. CIRCULATION. 92:76-76.
• BALIGA R; LAMMERTSMA A; RHODES C; AITMAN T; SCOTT J; KOONER JS. (15 Oct 1995). POSITRON EMISSION TOMOGRAPHY LOCALIZES INSULIN-RESISTANCE TO SKELETAL-MUSCLE IN PREMATURE CORONARY HEART-DISEASE. CIRCULATION. 92:77-77.
• SCOTT J. (16 Jun 1995). A PLACE IN THE WORLD FOR RNA EDITING. CELL. 81:833-836.
• NAVARATNAM N; BHATTACHARYA S; FUJINO T; PATEL D; JARMUZ AL; SCOTT J. (21 Apr 1995). EVOLUTIONARY ORIGINS OF APO-B MESSENGER-RNA EDITING - CATALYSIS BY A CYTIDINE DEAMINASE THAT HAS ACQUIRED A NOVEL RNA-BINDING MOTIF AT ITS ACTIVE-SITE. CELL. 81:187-195.
• DAVIDSON NO; INNERARITY TL; SCOTT J; SMITH H; DRISCOLL DM; TENG B; CHAN L. (Mar 1995). PROPOSED NOMENCLATURE FOR THE CATALYTIC SUBUNIT OF THE MAMMALIAN APOLIPOPROTEIN-B MESSENGER-RNA EDITING ENZYME - APOBEC-1. RNA. 1:3-3.
• Verhoeven AJ; Woods A; Brennan CH; Hawley SA; Hardie DG; Scott J; Beri RK; Carling D. (1 Mar 1995). The AMP-activated protein kinase gene is highly expressed in rat skeletal muscle. Alternative splicing and tissue distribution of the mRNA. Eur J Biochem. 228:236-243.
• TENG BB; BLUMENTHAL S; FORTE T; NAVARATNAM N; SCOTT J; GOTTO AM; CHAN L. (25 Nov 1994). ADENOVIRUS-MEDIATED GENE-TRANSFER OF RAT APOLIPOPROTEIN-B MESSENGER-RNA-EDITING PROTEIN IN MICE VIRTUALLY ELIMINATES APOLIPOPROTEIN B-100 AND NORMAL LOW-DENSITY-LIPOPROTEIN PRODUCTION. J BIOL CHEM. 269:29395-29404.
• Aguan K; Scott J; See CG; Sarkar NH. (18 Nov 1994). Characterization and chromosomal localization of the human homologue of a rat AMP-activated protein kinase-encoding gene: a major regulator of lipid metabolism in mammals. Gene. 149:345-350.
• TENG BB; BLUMENTHAL S; FORTE T; NAVARATNAM N; GOTTO AM; SCOTT J; CHAN L. (Oct 1994). ADENOVIRUS-MEDIATED GENE-TRANSFER OF RAT APOLIPOPROTEIN-B (APO-B) MESSENGER-RNA EDITING ENZYME IN MICE ELIMINATES APOB100 AND NORMAL LOW-DENSITY-LIPOPROTEIN PRODUCTION. CIRCULATION. 90:1-1.
• HUGHES SD; ROUY D; NAVARA N; SCOTT J; RUBIN EM. (Oct 1994). INTRODUCTION OF APOLIPOPROTEIN-B MESSENGER-RNA EDITING FACTOR P27 INCREASES IN-VIVO HEPATIC APO-B EDITING IN RABBITS AND MICE. CIRCULATION. 90:1-1.
• CULLEN P; FARREN B; SCOTT J; FARRALL M. (Aug 1994). COMPLEX SEGREGATION ANALYSIS PROVIDES EVIDENCE FOR A MAJOR GENE ACTING ON SERUM TRIGLYCERIDE LEVELS IN 55 BRITISH FAMILIES WITH FAMILIAL COMBINED HYPERLIPIDEMIA. ARTERIOSCLER THROMB. 14:1233-1249.
• Scott J; Navaratnam N; Bhattacharya S; Morrison JR. (Apr 1994). The apolipoprotein B messenger RNA editing enzyme. Curr Opin Lipidol. 5:87-93.
• Bhattacharya S; Navaratnam N; Morrison JR; Scott J; Taylor WR. (Mar 1994). Cytosine nucleoside/nucleotide deaminases and apolipoprotein B mRNA editing. Trends Biochem Sci. 19:105-106.
• SHOULDERS CC; BRETT DJ; BAYLISS JD; NARCISI TME; JARMUZ A; GRANTHAM TT; LEONI PRD; BHATTACHARYA S; et al. (Dec 1993). ABETALIPOPROTEINEMIA IS CAUSED BY DEFECTS OF THE GENE ENCODING THE 97 KDA SUBUNIT OF A MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN. HUM MOL GENET. 2:2109-2116.
• Navaratnam N; Morrison JR; Bhattacharya S; Patel D; Funahashi T; Giannoni F; Teng BB; Davidson NO; et al. (5 Oct 1993). The p27 catalytic subunit of the apolipoprotein B mRNA editing enzyme is a cytidine deaminase. J Biol Chem. 268:20709-20712.
• PATEL SB; PESSAH M; BEUCLER I; SCOTT J; NAVARRO J; INFANTE R. (Oct 1992). DETECTION OF NORMALLY EDITED APOLIPOPROTEIN-B MESSENGER-RNA IN ANDERSON DISEASE - A DEFECT OF LIPOPROTEIN ASSEMBLY. CIRCULATION. 86:208-208.

Conferences

• SCOTT J. APOLIPOPROTEIN-B AND CORONARY HEART-DISEASE. From Genetics to Gene Therapy Meeting. 7-23. (1994).

Patents

• Collaboration with Tim Aitman. Patent number: T.B.C..
• Perlegen Science. Patent number: Consultant. Application: Just initiated. NULL.
• Suppression of disorders of lipid excess. Freemont PP; Shoulders DC.