Dr Jennifer H Steel

Employment history:

1985-1995: Histochemistry Department, Royal Postgraduate Medical School, Hammersmith Hospital, London.  Head of Department: Professor Julia M. Polak. PhD entitled "A New Peptide Neuroendocrinology of the Pituitary Gland".

1995-1999: Postdoctoral Research Fellow at Histopathology Unit, Imperial Cancer Research Fund, London. Head of Department: Professor N.A. Wright.

1999-2001: Postdoctoral Research Associate with Dr M.H.F. Sullivan and Professor A.D. Edwards, Department of Maternal and Fetal Medicine, IRDB, Imperial College London. 

June 2001 – present: Research Officer with Professor Malcolm Parker at the IRDB,  Imperial College London.

RECENT PUBLICATIONS:

 1. Leonardsson G, Steel J.H, Christian M, Pocock V, Milligan S, Bell J, So P.W, Medina-Gomez G, Vidal-Puig A, White R, Parker M.G. Nuclear receptor corepressor RIP140 regulates fat accumulation. PNAS, 101:8437-8442, 2004.

 2. Steel J.H, White R, Parker MG.  Role of the RIP140 corepressor in ovulation and adipose biology (Review).  Journal of Endocrinology,185:1-9, 2005.

 3. Tullet J.M.A, Pocock V, Steel J.H, White R, Milligan S, Parker M.G.  Multiple signalling defects in the absence of RIP140 impair both cumulus expansion and follicle rupture. Endocrinology, 146:4127-4137, 2005.

 4. Nichol D, Christian M, Steel J.H, White R, Parker M.G.  RIP140 expression is stimulated by estrogen-related receptor alpha during adipogenesis.  Journal of Biological Chemistry, 281:32140-32147, 2006.

 5. Seth A, Steel J.H, Nichol D, Pocock V, Kumaran M.K, Fritah A, Mobberley M, Ryder T.A, Rowlerson A, Scott J, Poutanen M, White R, Parker M.G.  The transcriptional corepressor RIP140 regulates oxidative metabolism in skeletal muscle. Cell Metabolism, 6:236-245, 2007.

 6. Fritah A, Steel J.H, Nichol D, Parker N, Williams S, Price A, Strauss L, Ryder T.A, Mobberley M.A, Poutanen M, Parker M, White R.  Elevated expression of the metabolic regulator RIP140 results in cardiac hypertrophy and impaired cardiac function. Cardiovascular Research, 86:443-451, 2010.

7. Nautiyal J, Steel J.H, Rosell M.M, Nikolopoulou E, Lee K,  DeMayo F.J, White R, Richards J.S, Parker M.G. The nuclear receptor cofactor RIP140 is a positive regulator of Amphiregulin Expression and Cumulus Cell-Oocyte Complex Expansion in the Mouse Ovary.  Endocrinology, 151:2923-2932, 2010.