Dr Jian G Chai

Publications


Journals

  • Chai J-G. (1 May 2011). Cancer vaccination reprograms regulatory T cells into helper CD4 T cells to promote antitumor CD8 T-cell responses. IMMUNOTHERAPY. 3:601-604. DOI.
  • Fu H; Khan A; Coe D; Zaher S; Chai JG; Kropf P; Müller I; Larkin DF; et alGeorge AJ. (Oct 2011). Arginine depletion as a mechanism for the immune privilege of corneal allografts. Eur J Immunol. 41:2997-3005. DOI.
  • Chai JG. (May 2011). Cancer vaccination reprograms regulatory T cells into helper CD4 T cells to promote antitumor CD8 T-cell responses. Immunotherapy. 3:601-604. DOI.
  • Derbyshire K; Addey C; Coe D; Stuckey DW; Muezzin H; Bubier JA; Shaffer DJ; Roopenian DC; et alChai JG; Scott DM. (13 Apr 2011). Molecular Mechanisms of Induction of Antigen-Specific Allograft Tolerance by Intranasal Peptide Administration. J Immunol. 186:5719-5728. DOI.
  • Addey C; White M; Dou L; Coe D; Dyson J; Chai JG. (15 Apr 2011). Functional plasticity of antigen-specific regulatory T cells in context of tumor. J Immunol. 186:4557-4564. DOI.
  • Manzo T; Hess Michelini R; Basso V; Ricupito A; Chai JG; Simpson E; Bellone M; Mondino A. (1 Feb 2011). Concurrent allorecognition has a limited impact on posttransplant vaccination. J Immunol. 186:1361-1368. DOI.
  • Flutter B; Edwards N; Fallah-Arani F; Henderson S; Chai JG; Sivakumaran S; Ghorashian S; Bennett CL; et alFreeman GJ; Sykes M; Chakraverty R. (Nov 2010). Nonhematopoietic antigen blocks memory programming of alloreactive CD8+ T cells and drives their eventual exhaustion in mouse models of bone marrow transplantation. J Clin Invest. 120:3855-3868. DOI.
  • Ma L; Mauro C; Cornish GH; Chai JG; Coe D; Fu H; Patton D; Okkenhaug K; et alFranzoso G; Dyson J; Nourshargh S; Marelli-Berg FM. (9 Nov 2010). Ig gene-like molecule CD31 plays a nonredundant role in the regulation of T-cell immunity and tolerance. Proc Natl Acad Sci U S A. 107:19461-19466. DOI.
  • Coe D; Addey C; White M; Simpson E; Dyson J; Chai JG. (Dec 2010). The roles of antigen-specificity, responsiveness to transforming growth factor-β and antigen-presenting cell subsets in tumour-induced expansion of regulatory T cells. Immunology. 131:556-569. DOI.
  • Coe D; Begom S; Addey C; White M; Dyson J; Chai JG. (Sep 2010). Depletion of regulatory T cells by anti-GITR mAb as a novel mechanism for cancer immunotherapy. Cancer Immunol Immunother. 59:1367-1377. DOI.
  • Brzostek J; Chai JG; Gebhardt F; Busch DH; Zhao R; van der Merwe PA; Gould KG. (Jul 2010). Ligand dimensions are important in controlling NK-cell responses. Eur J Immunol. 40:2050-2059. DOI.
  • Baruah P; Simpson E; Dumitriu IE; Derbyshire K; Coe D; Addey C; Dyson J; Chai JG; et alCook T; Scott D; Botto M. (Jun 2010). Mice lacking C1q or C3 show accelerated rejection of minor H disparate skin grafts and resistance to induction of tolerance. Eur J Immunol. 40:1758-1767. DOI.
  • Furmanski AL; Bartok I; Chai JG; Singh Y; Ferreira C; Scott D; Holland SJ; Bourdeaux C; et alCrompton T; Dyson J. (15 Jan 2010). Peptide-specific, TCR-alpha-driven, coreceptor-independent negative selection in TCR alpha-chain transgenic mice. J Immunol. 184:650-657. DOI.
  • David R; Ma L; Ivetic A; Takesono A; Ridley AJ; Chai JG; Tybulewicz VL; Marelli-Berg FM. (16 Apr 2009). T-cell receptor- and CD28-induced Vav1 activity is required for the accumulation of primed T cells into antigenic tissue. Blood. 113:3696-3705. DOI.
  • Weng L; Addey C; Warrens AN; Dyson J; Chai JG; Dazzi F. (15 Nov 2008). Dissection of effector pathways in the host-versus-graft response to bone marrow transplantation. Transplantation. 86:1311-1314. DOI.
  • Jarmin SJ; David R; Ma L; Chai J-G; Dewchand H; Takesono A; Ridley AJ; Okkenhaug K; et alMarelli-Berg FM. (1 Mar 2008). T cell receptor-induced phosphoinositide-3-kinase p110 delta activity is required for T cell localization to antigenic tissue in mice. JOURNAL OF CLINICAL INVESTIGATION. 118:1154-1164. Author weblink DOI.
  • Chai J-G; Coe D; Chen D; Simpson E; Dyson J; Scott D. (15 Jan 2008). In vitro expansion improves in vivo regulation by CD4(+)CD25(+) regulatory T cells. JOURNAL OF IMMUNOLOGY. 180:858-869. Author weblink.
  • Robertson NJ; Chai JG; Millrain M; Scott D; Hashim F; Manktelow E; Lemonnier F; Simpson E; et alDyson J. (15 Mar 2007). Natural regulation of immunity to minor histocompatibility antigens. J Immunol. 178:3558-3565.
  • NAGASAWA H; OKA M; MAEDA K; CHAI JG; HISAEDA H; ITO Y; GOOD RA; HIMENO K. (1 Apr 1992). INDUCTION OF HEAT-SHOCK PROTEIN CLOSELY CORRELATES WITH PROTECTION AGAINST TOXOPLASMA-GONDII INFECTION. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 89:3155-3158. Author weblink DOI.
  • Lechler R; Chai JG; Vendetti S; Bartok I; Antoniou A; Dyson J. (15 Apr 1999). The induction and regulatory role of anergic T cells in transplant tolerance. TRANSPLANTATION. 67:S121-S121. Author weblink DOI.
  • Scott D; Dewchand H; Simpson E; Chai JG. (1 Dec 2005). Transplantation tolerance induced by intranasal administration of HY peptides. IMMUNOLOGY. 116:44-45. Author weblink.
  • Chai JG; Bando T; Kobashi S; Oka M; Nagasawa H; Nakai S; Maeda K; Himeno K; et alSato M; Ohkubo S. (1992). An extract of seeds from Aeginetia indica L., a parasitic plant, induces potent antigen-specific antitumor immunity in Meth A-bearing BALB/c mice. Cancer Immunol Immunother. 35:181-185.
  • Chai JG; Bando T; Nagasawa H; Himeno K; Sato M; Ohkubo S. (Jan 1994). Seed extract of Aeginetia indica L induces cytokine production and lymphocyte proliferation in vitro. Immunopharmacology. 27:13-21.
  • Chai JG; Okamoto M; Bando T; Nagasawa H; Hisaeda H; Sakai T; Himeno K; Sato M; et alOhkubo S. (Sep 1995). Dissociation between the mitogenic effect and antitumor activity of seed extract from Aeginetia indica L. Immunopharmacology. 30:209-215.
  • Chai JG; Sakai T; Hisaeda H; Nagasawa H; Yasutomo K; Furukawa A; Ishikawa H; Maekawa Y; et alUehara H; Izumi K; Matsumoto K; Himeno K. (1996). Development of functional rat-derived T cells in SCID mice engrafted with the fetal thymus of LEC rats which are defective in CD4+ T cells. Microbiol Immunol. 40:659-664.
  • Chai JG; Lechler RI. (Jul 1997). Immobilized anti-CD3 mAb induces anergy in murine naive and memory CD4+ T cells in vitro. Int Immunol. 9:935-944.
  • Chai JG; Bartok I; Scott D; Dyson J; Lechler R. (15 Apr 1998). T:T antigen presentation by activated murine CD8+ T cells induces anergy and apoptosis. J Immunol. 160:3655-3665.
  • Chai JG; Bartok I; Chandler P; Vendetti S; Antoniou A; Dyson J; Lechler R. (Feb 1999). Anergic T cells act as suppressor cells in vitro and in vivo. Eur J Immunol. 29:686-692. DOI.
  • Chai JG; Vendetti S; Bartok I; Schoendorf D; Takacs K; Elliott J; Lechler R; Dyson J. (1 Aug 1999). Critical role of costimulation in the activation of naive antigen-specific TCR transgenic CD8+ T cells in vitro. J Immunol. 163:1298-1305.
  • Vendetti S; Chai JG; Dyson J; Simpson E; Lombardi G; Lechler R. (1 Aug 2000). Anergic T cells inhibit the antigen-presenting function of dendritic cells. J Immunol. 165:1175-1181.
  • Chai JG; Vendetti S; Amofah E; Dyson J; Lechler R. (15 Sep 2000). CD152 ligation by CD80 on T cells is required for the induction of unresponsiveness by costimulation-deficient antigen presentation. J Immunol. 165:3037-3042.
  • Lechler R; Chai JG; Marelli-Berg F; Lombardi G. (29 May 2001). T-cell anergy and peripheral T-cell tolerance. Philos Trans R Soc Lond B Biol Sci. 356:625-637. DOI.
  • Lechler R; Chai JG; Marelli-Berg F; Lombardi G. (Jul 2001). The contributions of T-cell anergy to peripheral T-cell tolerance. Immunology. 103:262-269.
  • Chai JG; Tsang JY; Lechler R; Simpson E; Dyson J; Scott D. (Aug 2002). CD4+CD25+ T cells as immunoregulatory T cells in vitro. Eur J Immunol. 32:2365-2375. DOI.
  • James E; Scott D; Chai JG; Millrain M; Chandler P; Simpson E. (Nov 2002). HY peptides modulate transplantation responses to skin allografts. Int Immunol. 14:1333-1342.
  • Tsang JY; Chai JG; Lechler R. (Nov 2002). Acquisition of MHC:peptide complexes by mouse CD4+ T cells may play a role in T-cell-mediated immunoregulation. Transplant Proc. 34:2849-2850.
  • Tsang JY; Chai JG; Lechler R. (1 Apr 2003). Antigen presentation by mouse CD4+ T cells involving acquired MHC class II:peptide complexes: another mechanism to limit clonal expansion?. Blood. 101:2704-2710. DOI.
  • James E; Chai JG; Dewchand H; Macchiarulo E; Dazzi F; Simpson E. (1 Jul 2003). Multiparity induces priming to male-specific minor histocompatibility antigen, HY, in mice and humans. Blood. 102:388-393. DOI.
  • Chai JG; James E; Dewchand H; Simpson E; Scott D. (15 May 2004). Transplantation tolerance induced by intranasal administration of HY peptides. Blood. 103:3951-3959. DOI.
  • Silk JD; Schoendorf D; Bartok I; Chai JG; Gray D; Simpson E; Dyson J. (Jun 2005). Mixed-haplotype MHC class II molecules select functional CD4+ T cells. Mol Immunol. 42:1129-1139. DOI.
  • Chai JG; Xue SA; Coe D; Addey C; Bartok I; Scott D; Simpson E; Stauss HJ; et alHori S; Sakaguchi S; Dyson J. (27 May 2005). Regulatory T cells, derived from naïve CD4+CD25- T cells by in vitro Foxp3 gene transfer, can induce transplantation tolerance. Transplantation. 79:1310-1316.

Conferences

  • Fernandes E; Dyson J; Coe D; Chai J-G; Sing Y. In Vivo Model of Specific Tranplantation Tolerance Induced through the Genetic Modification of Naive CD4+T Cells with Foxp3 and Allograft Specific TCR Genes. 9th Joint Meeting of the American-Society-of-Transplant-Surgeon/American-Society-of-Transplantation, 30 May 2009 - 3 Jun 2009. 9:627-627. WILEY-BLACKWELL PUBLISHING, INC (1 Jan 2009). Author weblink.
  • Derbyshire K; Coe D; Chai J; Scott D. Intranasal administration of HY peptides induces FoxP3 and alters the migratory properties of antigen specific T cells. 8th American Transplant Congress, 31 May 2008 - 4 Jun 2008. 8:484-484. BLACKWELL PUBLISHING (1 May 2008). Author weblink.
  • Chai JG; Coe D; Cerundolo V; Stevenson F; Simpson E; Scott D; Dyson J. Vaccination strategies for breaking induced tolerance to HY antigens. Keystone Symposia, 28 Mar 2007 - 2 Apr 2007. Keystone sympoisa (28 Mar 2007).
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