Dr Jonathan L Dean

Publications


Journals

  • Marchese FP; Aubareda A; Tudor C; Saklatvala J; Clark A; Dean JL. (2010). MAPKAP kinase 2 blocks tristetraprolin-directed mRNA decay by inhibiting CAF1 deadenylase recruitment. J Biol Chem. 285:27590-27600.
  • Clark AR; Dean JL; Saklatvala J. (Nov 2009). The p38 MAPK pathway mediates both antiinflammatory and proinflammatory processes: comment on the article by Damjanov and the editorial by Genovese. Arthritis Rheum. 60:3513-3514. DOI.
  • Tudor C; Marchese FP; Hitti E; Aubareda A; Rawlinson L; Gaestel M; Blackshear PJ; Clark AR; et alSaklatvala J; Dean JL. (18 Jun 2009). The p38 MAPK pathway inhibits tristetraprolin-directed decay of interleukin-10 and pro-inflammatory mediator mRNAs in murine macrophages. FEBS Lett. 583:1933-1938. DOI.
  • Clark A; Dean J; Tudor C; Saklatvala J. (1 Jan 2009). Post-transcriptional gene regulation by MAP kinases via AU-rich elements. FRONTIERS IN BIOSCIENCE. 14:847-871. Author weblink DOI.
  • Enesa K; Ito K; Luong LEA; Thorbjornsen I; Phua C; To Y; Dean J; Haskard DO; et alBoyle J; Adcock I; Evans PC. (4 Jul 2008). Hydrogen peroxide prolongs nuclear localization of NF-kappaB in activated cells by suppressing negative regulatory mechanisms. J Biol Chem. 283:18582-18590. DOI.
  • Enesa K; Zakkar M; Chaudhury H; Luong LEA; Rawlinson L; Mason JC; Haskard DO; Dean JL; et alEvans PC. (14 Mar 2008). NF-kappaB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signaling. J Biol Chem. 283:7036-7045. DOI.
  • Alford KA; Glennie S; Turrell BR; Rawlinson L; Saklatvala J; Dean JL. (2 Mar 2007). Heat shock protein 27 functions in inflammatory gene expression and transforming growth factor-beta-activated kinase-1 (TAK1)-mediated signaling. J Biol Chem. 282:6232-6241. DOI.
  • Paradisi F; Dean JL; Geoghegan KF; Engel PC. (8 Mar 2005). Spontaneous chemical reversion of an active site mutation: deamidation of an asparagine residue replacing the catalytic aspartic acid of glutamate dehydrogenase. Biochemistry. 44:3636-3643. DOI.
  • Dean JL; Sully G; Clark AR; Saklatvala J. (Oct 2004). The involvement of AU-rich element-binding proteins in p38 mitogen-activated protein kinase pathway-mediated mRNA stabilisation. Cell Signal. 16:1113-1121. DOI.
  • Sully G; Dean JL; Wait R; Rawlinson L; Santalucia T; Saklatvala J; Clark AR. (1 Feb 2004). Structural and functional dissection of a conserved destabilizing element of cyclo-oxygenase-2 mRNA: evidence against the involvement of AUF-1 [AU-rich element/poly(U)-binding/degradation factor-1], AUF-2, tristetraprolin, HuR (Hu antigen R) or FBP1 (far-upstream-sequence-element-binding protein 1). Biochem J. 377:629-639. DOI.
  • Saklatvala J; Dean J; Clark A. (2003). Control of the expression of inflammatory response genes. Biochem Soc Symp. 95-106.
  • Dean JL; Sarsfield SJ; Tsounakou E; Saklatvala J. (10 Oct 2003). p38 Mitogen-activated protein kinase stabilizes mRNAs that contain cyclooxygenase-2 and tumor necrosis factor AU-rich elements by inhibiting deadenylation. J Biol Chem. 278:39470-39476. DOI.
  • Clark AR; Dean JL; Saklatvala J. (3 Jul 2003). Post-transcriptional regulation of gene expression by mitogen-activated protein kinase p38. FEBS Lett. 546:37-44.
  • Dean JL; Sully G; Wait R; Rawlinson L; Clark AR; Saklatvala J. (15 Sep 2002). Identification of a novel AU-rich-element-binding protein which is related to AUF1. Biochem J. 366:709-719. DOI.
  • Mahtani KR; Brook M; Dean JL; Sully G; Saklatvala J; Clark AR. (Oct 2001). Mitogen-activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stability. Mol Cell Biol. 21:6461-6469.
  • Dean JL; Wait R; Mahtani KR; Sully G; Clark AR; Saklatvala J. (Feb 2001). The 3' untranslated region of tumor necrosis factor alpha mRNA is a target of the mRNA-stabilizing factor HuR. Mol Cell Biol. 21:721-730. DOI.
  • Staniforth RA; Dean JL; Zhong Q; Zerovnik E; Clarke AR; Waltho JP. (23 May 2000). The major transition state in folding need not involve the immobilization of side chains. Proc Natl Acad Sci U S A. 97:5790-5795.
  • Hayden BM; Dean JL; Martin SR; Engel PC. (1 Jun 1999). Chemical rescue of the catalytically disabled clostridial glutamate dehydrogenase mutant D165S by fluoride ion. Biochem J. 340 ( Pt 2):555-560.
  • Saklatvala J; Dean J; Finch A. Downes CP (ed); Wolf CR (ed); Lane DP (ed). (1 Jan 1999). Protein kinase cascades in intracellular signalling by interleukin-1 and tumour necrosis factor. CELLULAR RESPONSES TO STRESS. 63-77. Author weblink.
  • Dean JL; Brook M; Clark AR; Saklatvala J. (1 Jan 1999). p38 mitogen-activated protein kinase regulates cyclooxygenase-2 mRNA stability and transcription in lipopolysaccharide-treated human monocytes. J Biol Chem. 274:264-269.
  • Ridley SH; Dean JL; Sarsfield SJ; Brook M; Clark AR; Saklatvala J. (13 Nov 1998). A p38 MAP kinase inhibitor regulates stability of interleukin-1-induced cyclooxygenase-2 mRNA. FEBS Lett. 439:75-80.
  • Dean JL; Cölfen H; Harding SE; Rice DW; Engel PC. (1997). Alteration of the quaternary structure of glutamate dehydrogenase from Clostridium symbiosum by a single mutation distant from the subunit interfaces. Eur Biophys J. 25:417-422.
  • Wang XG; Dean JL; Engel PC; Baker PJ; Britton KL; Stillman TJ; Rice DW. (Aug 1994). The changed pattern of substrate specificity in the K89L mutant of glutamate dehydrogenase of Clostridium symbiosum. Biochem Soc Trans. 22:320S.
  • Dean JL; Wang XG; Teller JK; Waugh ML; Britton KL; Baker PJ; Stillman TJ; Martin SR; et alRice DW; Engel PC. (1 Jul 1994). The catalytic role of aspartate in the active site of glutamate dehydrogenase. Biochem J. 301 ( Pt 1):13-16.
  • Korber FCF; Rizkallah PJ; Attwood TK; Wootton JC; McPherson MJ; North ACT; Geddes AJ; Abeysinghe SB; et alBaker PJ; Dean JL; Engel PC; Stillman TJ; Rice DW. (1993). Crystallization of the NADP+-dependent glutamate dehydrogenase from Escherichia coli. J. Mol. Biol. 234:1270-1273.

Chapters in books

  • Dean JLE. The control of mRNA stability by p38 mitogen-activated protein kinase and tristetraprolin. In Messenger RNA Research Perspectives. 1:19-26. Takeyama T (ed). Nova Science Publishers, New York (2008). Publisher weblink.
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