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Dr Justin E Davies

Clinical Research Fellow
National Heart & Lung Institute

Tel: +44 (0)20 7594 1024
Email: Email address for Dr Justin E Davies

Dr Justin E Davies

Justin Davies is a Walport Clinical Lecturer and Hononary Consultant Cardiologist at the National Heart and Lung Institute. His main research interests include the development and application of pioneering technological developments in engineering to aid understanding of disease mechanisms, and in the diagnosis of pathological disease states.

After completing his undergraduate training at Imperial College, he was awarded a British Heart Foundation research fellowship to undertake a PhD with Alun Hughes and Jamil Mayet in 2003. Since then, he has trained in interventional cardiology with a specialist interest in physiological and structural assessment of coronary disease states. In 2008, he was appointed as a Walport Clinical Lecturer to support his research activities alongside his ongoing clinical commitments.

Through collaboration with Kim Parker and Rob Krams at Imperial College, and colleagues at institutions throughout the world, he has used mathematical modelling to aid understand of the mechanisms which lead to increased blood pressure which accompany ageing and pathological disease states, and in the development of non-invasive and invasive techniques to assess the interaction between the coronary microcirculation and the aorta to aid diagnosis of myocardial, valvular and coronary disease states.

These techniques have led to development of the reservoir pressure model, which has been shown to be highly predictive of cardiovascular events in 2069 patients in the CAFE sub-study of the ASCOT trial, and to describe the minimum pressure needed to overcome the compliance and resistance of the aorta.

The primary results of ADVISE (ADenosine Vasodilator Independent Stenosis Evaluation) was reported at TCT 2011, and subsequently published in Journal of American College of Cardiology. The slideset can be obtained here. This was an investigator led study testing the development of new methodologies to determine the severity of coronary stenoses to determine a measure of fractional flow reserve (FFR) without the need for administration of pharmocological vasodilators. This process works by identifying the wave-free period, a phase of the cardiac cycle when resistance is naturally stable. More recently the results of a large multi-centre international registry ADVISE-Registy were presented at EuroPCR 2012 along side an independent blinded study by Dr Park from South Korea. A summary slide deck of the ADVISE-Registry from EuroPCR 2012 can be downloaded here, and further exploration from ESC 2012 here.

The ADVISE studies are a group of multi-centre international studies whos PI's are Javier Escaned, Carlo Di Mario, Simon Redwood and Justin Davies.

Selected Publications

Journals

Sen S; Asrress KN; Nijjer S; Petraco R; Malik IS; Foale RA; Mikhail GW; Foin N; et alBroyd C; Hadjiloizou N; Sethi A; Al-Bustami M; Hackett D; Khan MA; Khawaja MZ; Baker CS; Bellamy M; Parker KH; Hughes AD; Francis DP; Mayet J; Di Mario C; Escaned J; Redwood S; Davies JE. (2 Apr 2013). Diagnostic classification of the instantaneous wave-free ratio is equivalent to fractional flow reserve and is not improved with adenosine administration. Results of CLARIFY (Classification Accuracy of Pressure-Only Ratios Against Indices Using Flow Study). J Am Coll Cardiol. 61:1409-1420. Author weblink DOI.
Kyriacou A; Whinnett ZI; Sen S; Pabari PA; Wright I; Cornelussen R; Lefroy D; Davies DW; et alPeters NS; Kanagaratnam P; Mayet J; Hughes AD; Francis DP; Davies JE. (11 Sep 2012). Improvement in coronary blood flow velocity with acute biventricular pacing is predominantly due to an increase in a diastolic backward-travelling decompression (suction) wave. Circulation. 126:1334-1344. Author weblink DOI.
Davies JE; Alastruey J; Francis DP; Hadjiloizou N; Whinnett ZI; Manisty CH; Aguado-Sierra J; Willson K; et alFoale RA; Malik IS; Hughes AD; Parker KH; Mayet J. (Sep 2012). Attenuation of wave reflection by wave entrapment creates a "horizon effect" in the human aorta. Hypertension. 60:778-785. Author weblink DOI.
Sen S; Escaned J; Malik IS; Mikhail GW; Foale RA; Mila R; Tarkin J; Petraco R; et alBroyd C; Jabbour R; Sethi A; Baker CS; Bellamy M; Al-Bustami M; Hackett D; Khan M; Lefroy D; Parker KH; Hughes AD; Francis DP; Di Mario C; Mayet J; Davies JE. (10 Apr 2012). Development and validation of a new adenosine-independent index of stenosis severity from coronary wave-intensity analysis: results of the ADVISE (ADenosine Vasodilator Independent Stenosis Evaluation) study. J Am Coll Cardiol. 59:1392-1402. Author weblink DOI.
Davies JE; Sen S; Broyd C; Hadjiloizou N; Baksi J; Francis DP; Foale RA; Parker KH; et alHughes AD; Chukwuemeka A; Casula R; Malik IS; Mikhail GW; Mayet J. (4 Oct 2011). Arterial pulse wave dynamics after percutaneous aortic valve replacement: fall in coronary diastolic suction with increasing heart rate as a basis for angina symptoms in aortic stenosis. Circulation. 124:1565-1572. Author weblink DOI.
Davies JE; Whinnett ZI; Francis DP; Manisty CH; Aguado-Sierra J; Willson K; Foale RA; Malik IS; et alHughes AD; Parker KH; Mayet J. (11 Apr 2006). Evidence of a dominant backward-propagating "suction" wave responsible for diastolic coronary filling in humans, attenuated in left ventricular hypertrophy. Circulation. 113:1768-1778. Author weblink DOI.
Hadjiloizou N; Davies JE; Malik IS; Aguado-Sierra J; Willson K; Foale RA; Parker KH; Hughes AD; et alFrancis DP; Mayet J. (Sep 2008). Differences in cardiac microcirculatory wave patterns between the proximal left mainstem and proximal right coronary artery. Am J Physiol Heart Circ Physiol. 295:H1198-H1205. Author weblink DOI.
Davies JE; Whinnett ZI; Francis DP; Willson K; Foale RA; Malik IS; Hughes AD; Parker KH; et alMayet J. (Feb 2006). Use of simultaneous pressure and velocity measurements to estimate arterial wave speed at a single site in humans. Am J Physiol Heart Circ Physiol. 290:H878-H885. Author weblink DOI.
Baksi AJ; Treibel TA; Davies JE; Hadjiloizou N; Foale RA; Parker KH; Francis DP; Mayet J; et alHughes AD. (24 Nov 2009). A meta-analysis of the mechanism of blood pressure change with aging. J Am Coll Cardiol. 54:2087-2092. Author weblink DOI.
Davies JE; Parker KH; Francis DP; Hughes AD; Mayet J. (1 Dec 2008). What is the role of the aorta in directing coronary blood flow?. HEART. 94:1545-1547. Author weblink DOI.
Sharman JE; Hare JL; Thomas S; Davies JE; Leano R; Jenkins C; Marwick TH. (1 Aug 2011). Association of Masked Hypertension and Left Ventricular Remodeling With the Hypertensive Response to Exercise. AMERICAN JOURNAL OF HYPERTENSION. 24:898-903. Author weblink DOI.
Davies JE; Unsworth B; Francis DP; Casula R; Sutaria N. (27 Jul 2010). A surgeon's eye view noninvasively. J Am Coll Cardiol. 56:e9. Author weblink DOI.
Baksi AJ; Treibel TA; Davies JE; Hadjiloizou N; Foale RA; Parker KH; Francis DP; Mayet J; et alHughes AD. (11 May 2010). Changes in the Central Arterial Pressure Pulse With Aging Reply. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 55:2183-2184. Author weblink DOI.
Davies JE; Baksi J; Francis DP; Hadjiloizou N; Whinnett ZI; Manisty CH; Aguado-Sierra J; Foale RA; et alMalik IS; Tyberg JV; Parker KH; Mayet J; Hughes AD. (Feb 2010). The arterial reservoir pressure increases with aging and is the major determinant of the aortic augmentation index. Am J Physiol Heart Circ Physiol. 298:H580-H586. Author weblink DOI.
Manisty CH; Zambanini A; Parker KH; Davies JE; Francis DP; Mayet J; Thom SAM; Hughes AD. (1 Oct 2009). Differences in the Magnitude of Wave Reflection Account for Differential Effects of Amlodipine- Versus Atenolol-Based Regimens on Central Blood Pressure An Anglo-Scandinavian Cardiac Outcome Trial Substudy. HYPERTENSION. 54:724-U73. Author weblink DOI.
Sharman JE; Davies JE; Jenkins C; Marwick TH. (Nov 2009). Augmentation index, left ventricular contractility, and wave reflection. Hypertension. 54:1099-1105. Author weblink DOI.
Tyberg JV; Davies JE; Wang Z; Whitelaw WA; Flewitt JA; Shrive NG; Francis DP; Hughes AD; et alParker KH; Wang J-J. (1 Feb 2009). Wave intensity analysis and the development of the reservoir-wave approach. MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING. 47:221-232. Author weblink DOI.

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