Contact details

Dr Justin E Davies

Walport Clinical Lecturer
National Heart & Lung Institute

Tel: +44 (0)20 7594 1024
Email: Email address for Dr Justin E Davies

Dr Justin E Davies

Justin Davies is a Walport Clinical Lecturer in Cardiology at the National Heart and Lung Institute. His main research interests include the development and application of pioneering technological developments in engineering to aid understanding of disease mechanisms, and in the diagnosis of pathological disease states.

After completing his undergraduate training at Imperial College, he was awarded a British Heart Foundation research fellowship to undertake a PhD with Alun Hughes and Jamil Mayet in 2003. Since then, he has trained in interventional cardiology with a specialist interest in physiological and structural assessment of coronary disease states. In 2008, he was appointed as a Walport Clinical Lecturer to support his research activities alongside his ongoing clinical commitments.

Through collaboration with Kim Parker and Rob Krams at Imperial College, and colleagues at institutions throughout the world, he has used mathematical modelling to aid understand of the mechanisms which lead to increased blood pressure which accompany ageing and pathological disease states, and in the development of non-invasive and invasive techniques to assess the interaction between the coronary microcirculation and the aorta to aid diagnosis of myocardial, valvular and coronary disease states.

These techniques have led to development of the reservoir pressure model, which has been shown to be highly predictive of cardiovascular events in 2069 patients in the CAFE sub-study of the ASCOT trial, and to describe the minimum pressure needed to overcome the compliance and resistance of the aorta.

The primary results of ADVISE (ADenosine Vasodilator Independent Stenosis Evaluation) was reported at TCT 2011, and subsequently published in Journal of American College of Cardiology. The slideset can be obtained here. This was an investigator led study testing the development of new methodologies to determine the severity of coronary stenoses to determine a measure of fractional flow reserve (FFR) without the need for administration of pharmocological vasodilators. This process works by identifying the wave-free period, a phase of the cardiac cycle when resistance is naturally stable. Justin is priniciple investigator of this multi-centre international study, alongside Javier Escaned and Carlo Di Mario as co-investigators.

Selected Publications

Journals

Davies JE; Sen S; Broyd C; Hadjiloizou N; Baksi J; Francis DP; Foale RA; Parker KH; et alHughes AD; Chukwuemeka A; Casula R; Malik IS; Mikhail GW; Mayet J. (4 Oct 2011). Arterial pulse wave dynamics after percutaneous aortic valve replacement: fall in coronary diastolic suction with increasing heart rate as a basis for angina symptoms in aortic stenosis. Circulation. 124:1565-1572. DOI.
Davies JE; Whinnett ZI; Francis DP; Manisty CH; Aguado-Sierra J; Willson K; Foale RA; Malik IS; et alHughes AD; Parker KH; Mayet J. (11 Apr 2006). Evidence of a dominant backward-propagating "suction" wave responsible for diastolic coronary filling in humans, attenuated in left ventricular hypertrophy. Circulation. 113:1768-1778. DOI.
Hadjiloizou N; Davies JE; Malik IS; Aguado-Sierra J; Willson K; Foale RA; Parker KH; Hughes AD; et alFrancis DP; Mayet J. (Sep 2008). Differences in cardiac microcirculatory wave patterns between the proximal left mainstem and proximal right coronary artery. Am J Physiol Heart Circ Physiol. 295:H1198-H1205. DOI.
Davies JE; Whinnett ZI; Francis DP; Willson K; Foale RA; Malik IS; Hughes AD; Parker KH; et alMayet J. (Feb 2006). Use of simultaneous pressure and velocity measurements to estimate arterial wave speed at a single site in humans. Am J Physiol Heart Circ Physiol. 290:H878-H885. DOI.
Baksi AJ; Treibel TA; Davies JE; Hadjiloizou N; Foale RA; Parker KH; Francis DP; Mayet J; et alHughes AD. (24 Nov 2009). A meta-analysis of the mechanism of blood pressure change with aging. J Am Coll Cardiol. 54:2087-2092. DOI.
Davies JE; Parker KH; Francis DP; Hughes AD; Mayet J. (Dec 2008). What is the role of the aorta in directing coronary blood flow?. HEART. 94:1545-1547. DOI.
Sharman JE; Hare JL; Thomas S; Davies JE; Leano R; Jenkins C; Marwick TH. (Aug 2011). Association of Masked Hypertension and Left Ventricular Remodeling With the Hypertensive Response to Exercise. AM J HYPERTENS. 24:898-903. DOI.
Davies JE; Unsworth B; Francis DP; Casula R; Sutaria N. (27 Jul 2010). A surgeon's eye view noninvasively. J Am Coll Cardiol. 56:e9. DOI.
Baksi AJ; Treibel TA; Davies JE; Hadjiloizou N; Foale RA; Parker KH; Francis DP; Mayet J; et alHughes AD. (11 May 2010). Changes in the Central Arterial Pressure Pulse With Aging Reply. J AM COLL CARDIOL. 55:2183-2184. DOI.
Davies JE; Baksi J; Francis DP; Hadjiloizou N; Whinnett ZI; Manisty CH; Aguado-Sierra J; Foale RA; et alMalik IS; Tyberg JV; Parker KH; Mayet J; Hughes AD. (Feb 2010). The arterial reservoir pressure increases with aging and is the major determinant of the aortic augmentation index. Am J Physiol Heart Circ Physiol. 298:H580-H586. DOI.
Manisty CH; Zambanini A; Parker KH; Davies JE; Francis DP; Mayet J; Thom SAM; Hughes AD; et alAnglo-Scandinavian Cardiac Outcome. (Oct 2009). Differences in the Magnitude of Wave Reflection Account for Differential Effects of Amlodipine- Versus Atenolol-Based Regimens on Central Blood Pressure An Anglo-Scandinavian Cardiac Outcome Trial Substudy. HYPERTENSION. 54:724-U73. DOI.
Sharman JE; Davies JE; Jenkins C; Marwick TH. (Nov 2009). Augmentation index, left ventricular contractility, and wave reflection. Hypertension. 54:1099-1105. DOI.
Tyberg JV; Davies JE; Wang ZB; Whitelaw WA; Flewitt JA; Shrive NG; Francis DP; Hughes AD; et alParker KH; Wang J. (Feb 2009). Wave intensity analysis and the development of the reservoir-wave approach. MED BIOL ENG COMPUT. 47:221-232. DOI.