Professor Ken Haynes

Publications


Journals

  • Stead DA; Walker J; Holcombe L; Gibbs SR; Yin Z; Selway L; Butler G; Brown AJ; et alHaynes K. (Jan 2010). Impact of the transcriptional regulator, Ace2, on the Candida glabrata secretome. Proteomics. 10:212-223. DOI.
  • Armstrong-James DP; Turnbull SA; Teo I; Stark J; Rogers NJ; Rogers TR; Bignell E; Haynes K. (15 Oct 2009). Impaired interferon-gamma responses, increased interleukin-17 expression, and a tumor necrosis factor-alpha transcriptional program in invasive aspergillosis. J Infect Dis. 200:1341-1351. DOI.
  • Brown AJP; Haynes K; Quinn J. (Aug 2009). Nitrosative and oxidative stress responses in fungal pathogenicity. CURR OPIN MICROBIOL. 12:384-391. DOI.
  • McDonagh A; Fedorova ND; Crabtree J; Yu Y; Kim S; Chen D; Loss O; Cairns T; et alGoldman G; Armstrong-James D; Haynes K; Haas H; Schrettl M; May G; Nierman WC; Bignell E. (2008). Sub-telomere directed gene expression during initiation of invasive aspergillosis. PLoS Pathog. 4:e1000154. DOI.
  • Sasse C; Bignell EM; Hasenberg M; Haynes K; Gunzer M; Braus GH; Krappmann S. (May 2008). Basal expression of the Aspergillus fumigatus transcriptional activator CpcA is sufficient to support pulmonary aspergillosis. FUNGAL GENET BIOL. 45:693-704. DOI.
  • Schrettl M; Bignell E; Kragl C; Sabiha Y; Loss O; Eisendle M; Wallner A; Arst HN; et alHaynes K. (2007). Distinct Roles for Intra- and Extracellular Siderophores during Aspergillus fumigatus Infection. PLoS Pathogens. 3.
  • Eckert SE; Heinz WJ; Zakikhany K; Thewes S; Haynes K; Hube B; Mühlschlegel FA. (May 2007). PGA4, a GAS homologue from Candida albicans, is up-regulated early in infection processes. Fungal Genet Biol. 44:368-377. DOI.
  • Taylor PR; Tsoni SV; Willment JA; Dennehy KM; Rosas M; Findon H; Haynes K; Steele C; et alBotto M; Gordon S; Brown GD. (Jan 2007). Dectin-1 is required for beta-glucan recognition and control of fungal infection. NAT IMMUNOL. 8:31-38.
  • MacCallum DM; Findon H; Kenny CC; Butler G; Haynes K; Odds FC. (Sep 2006). Different consequences of ACE2 and SWI5 gene disruptions for virulence of pathogenic and nonpathogenic yeasts. Infect Immun. 74:5244-5248. DOI.
  • Klengel T; Liang WJ; Chaloupka J; Ruoff C; Schroppel K; Naglik JR; Eckert SE; Mogensen EG; et alHaynes K; Tuite MF; Levin LR; Buck J; Muhlschlegel FA. (6 Dec 2005). Fungal adenylyl cyclase integrates CO2 sensing with cAMP signaling and virulence (vol 15, pg 2021, 2005). CURR BIOL. 15:2177-2177. DOI.
  • Sheth CC; Johnson E; Baker ME; Haynes K; Mühlschlegel FA. (Dec 2005). Phenotypic identification of Candida albicans by growth on chocolate agar. Med Mycol. 43:735-738.
  • Klengel T; Liang WJ; Chaloupka J; Ruoff C; Schröppel K; Naglik JR; Eckert SE; Mogensen EG; et alHaynes K; Tuite MF; Levin LR; Buck J; Mühlschlegel FA. (22 Nov 2005). Fungal adenylyl cyclase integrates CO2 sensing with cAMP signaling and virulence. Curr Biol. 15:2021-2026. DOI.
  • Bignell E; Negrete-Urtasun S; Calcagno AM; Arst HN; Rogers T; Haynes K. (Aug 2005). Virulence comparisons of Aspergillus nidulans mutants are confounded by the inflammatory response of p47phox-/- mice. Infect Immun. 73:5204-5207. DOI.
  • Calcagno AM; Bignell E; Rogers TR; Jones MD; Mühlschlegel FA; Haynes K. (Jun 2005). Candida glabrata Ste11 is involved in adaptation to hypertonic stress, maintenance of wild-type levels of filamentation and plays a role in virulence. Med Mycol. 43:355-364.
  • Stead D; Findon H; Yin Z; Walker J; Selway L; Cash P; Dujon BA; Hennequin C; et alBrown AJ; Haynes K. (May 2005). Proteomic changes associated with inactivation of the Candida glabrata ACE2 virulence-moderating gene. Proteomics. 5:1838-1848. DOI.
  • Bignell E; Negrete-Urtasun S; Calcagno AM; Haynes K; Arst HN; Rogers T. (Feb 2005). The Aspergillus pH-responsive transcription factor PacC regulates virulence. Mol Microbiol. 55:1072-1084. DOI.
  • Schrettl M; Bignell E; Kragl C; Joechl C; Rogers T; Arst HN; Haynes K; Haas H. (1 Nov 2004). Siderophore biosynthesis but not reductive iron assimilation is essential for Aspergillus fumigatus virulence. J Exp Med. 200:1213-1219. DOI.
  • Haynes K. (Aug 2004). Host-microbe interactions: fungi. CURR OPIN MICROBIOL. 7:321-323.
  • Calcagno AM; Bignell E; Rogers TR; Canedo M; Mühlschlegel FA; Haynes K. (May 2004). Candida glabrata Ste20 is involved in maintaining cell wall integrity and adaptation to hypertonic stress, and is required for wild-type levels of virulence. Yeast. 21:557-568. DOI.
  • Krappmann S; Bignell EM; Reichard U; Rogers T; Haynes K; Braus GH. (May 2004). The Aspergillus fumigatus transcriptional activator CpcA contributes significantly to the virulence of this fungal pathogen. Mol Microbiol. 52:785-799. DOI.
  • Kamran M; Calcagno AM; Findon H; Bignell E; Jones MD; Warn P; Hopkins P; Denning DW; et alButler G; Rogers T; Mühlschlegel FA; Haynes K. (Apr 2004). Inactivation of transcription factor gene ACE2 in the fungal pathogen Candida glabrata results in hypervirulence. Eukaryot Cell. 3:546-552.
  • Calcagno AM; Bignell E; Warn P; Jones MD; Denning DW; Mühlschlegel FA; Rogers TR; Haynes K. (Nov 2003). Candida glabrata STE12 is required for wild-type levels of virulence and nitrogen starvation induced filamentation. Mol Microbiol. 50:1309-1318.
  • Haynes K. (Dec 2001). Virulence in Candida species. Trends Microbiol. 9:591-596.
  • Weig M; Haynes K; Rogers TR; Kurzai O; Frosch M; Mühlschlegel FA. (Aug 2001). A GAS-like gene family in the pathogenic fungus Candida glabrata. Microbiology. 147:2007-2019.
  • Csank C; Haynes K. (1 Aug 2000). Candida glabrata displays pseudohyphal growth. FEMS MICROBIOL LETT. 189:115-120.
  • El Barkani A; Haynes K; Mosch HU; Frosch M; Muhlschlegel FA. (4 Apr 2000). Candida glabrata shuttle vectors suitable for translational fusions to lacZ and use of beta-galactosidase as a reporter of gene expression. GENE. 246:151-155.
  • Gilfillan GD; Sullivan DJ; Haynes K; Parkinson T; Coleman DC; Gow NAR. (Apr 1998). Candida dubliniensis: phylogeny and putative virulence factors. MICROBIOL-SGM. 144:829-838.
  • Sullivan D; Haynes K; Bille J; Boerlin P; Rodero L; Lloyd S; Henman M; Coleman D. (Apr 1997). Widespread geographic distribution of oral Candida dubliniensis strains in human immunodeficiency virus-infected individuals. J CLIN MICROBIOL. 35:960-964.
  • HAYNES K; COLEMAN DC; SULLIVAN DJ. (Jun 1995). INVOLVEMENT OF MULTIPLE CRYPTOCOCCUS-NEOFORMANS STRAINS IN A SINGLE EPISODE OF CRYPTOCOCCOSIS AND REINFECTION WITH NOVEL STRAINS IN RECURRENT INFECTION DEMONSTRATED BY RANDOM AMPLIFICATION OF POLYMORPHIC DNA AND DNA-FINGERPRINTING - REPLY. J CLIN MICROBIOL. 33:1682-1683.
  • Haynes K; Rogers TR. (Aug 1994). Retrospective evaluation of a latex agglutination test for diagnosis of invasive aspergillosis in immunocompromised patients. Eur J Clin Microbiol Infect Dis. 13:670-674.
  • LATGE JP; MOUTAOUAKIL M; DEBEAUPUIS JP; BOUCHARA JP; HAYNES K; PREVOST MC. (Aug 1991). THE 18-KILODALTON ANTIGEN SECRETED BY ASPERGILLUS-FUMIGATUS. INFECT IMMUN. 59:2586-2594.
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