Dr Laurence S Carroll

Laurence obtained his DPhil in chemistry in 2010, under the supervison of Prof. V. Gouverneur at the University of Oxford (New College). His project centred on the development of novel F-18 labelled hypoxia-selective radiotracers based upon [18F]FMISO and [64Cu]Cu-ATSM.

He susequently moved to the department of Surgery and Oncology here at Imperial College. The project centres on imaging of the PI3K pathway using F-18 and C-11 labels on a wide variety of  target molecules.

 

Recent Publications

Copper-free Click – A Promising Tool for Pre-Targeted PET Imaging - H. L. Evans, R. L. Slade, L. Carroll, G. Smith, Q-D. Nguyen, L. Iddon, N. Kamaly, H. Stöckmann, F. J. Leeper,  E. O. Aboagye, A. C. Spivey, Chem. Commun. 2011, ASAP.

A Fluorous and Click Approach for Screening Potential PET Probes: Evaluation of Potential Hypoxia Biomarkers - R. Bejot, L. Carroll, K. Bhakoo, V. Gouverneur, Bioorg. Med. Chem. 2011, ASAP.

The Traceless Staudinger Ligation for Indirect ¹⁸F-Labelling  -  L. Carroll, S. Boldon, R. Bejot, J. E. Moore, J. Declerck, V. Gouverneur, Org. Biomol. Chem. 2011, 9 (1), 136-140.

Pre-clinical evaluation of a 3-nitro-1,2,4-triazole analogue of [¹⁸F]FMISO as hypoxia-selective tracer for PET  -  R. Bejot, V. Kersemans, C. Kelly, L. Carroll, R. C. King, V. Gouverneur, Nucl. Med. Biol. 2010, 37, 565-575.  

Orthogonal ¹⁸F and ⁶⁴Cu Labelling of Functionalised bis(thiosemicarbazonato) complexes  -  L. Carroll, R. Bejot, R. Hueting, R. King, P.Bonnitcha, S. Bayly, M. Christlieb, J. R. Dilworth, A. D. Gee, J. Declerck, V. Gouverneur, Chem. Commun. 2010 46, 4052-4054.

Fluorous Synthesis of 18F-Radiotracers with [¹⁸F]Fluoride ion: Nucleophilic Fluorination as the Detagging Process  -  R. Bejot, T. Fowler, L. Carroll, S. Boldon, J. E. Moore, J. Declerck, V. Gouverneur, Angew. Chem. Int. Ed. 2009, 48, 586-589.

Stereospecific anti SE2' Fluorination of Allenylsilanes: Synthesis of Enantioenriched Propargylic Fluorides  -  L. Carroll, S. McCullough, T. Rees, T. D. W. Claridge, V. Gouverneur, Org. Biomol. Chem. 2008, 6, 1731-1733.

Synthesis of Propargylic Fluorides from Allenylsilanes  -  L. Carroll, M. Pacheco, L. Garcia, V. Gouverneur, Chem. Commun. 2006, 4113-4115.