Contact details
Dr Lachlan J Coin
Research Fellow
Division of Epidemiology, Public Health and Primary Care
Tel: +44 (0)20 7594 1930
Email:
Dr Lachlan J Coin
I am a research fellow at Imperial College, working on various statistical and mathematical problems in genomics. I am particularly interested in building mathematical models to identify genetic variants in high-throughput genomics data - including genotyping microarrays and next generation sequence data - with the ultimate aim of understanding the functional impact and evolutionary history of these variants.
Supplementary information 
from paper "Pathway Analysis of GWAS Provides New Insights into Genetic Susceptibility to 3 Inflammatory Diseases"
Software:
cnvHap
cnvHap is a program for joint copy number genotyping and phasing, and integrates data from multiple platforms. It also carries out CN association. We presently have two concurrent releases of this software, each optimized for slightly different purposes:
- optimised for CNV/SNP genotyping from intensity data, as well as carrying out association analyses
cnvHap_1.02 
(right click, and save-as cnvHap1.02.zip)
- optimised for CNV phasing from pre-called CNV/SNP genotype data
cnvHap_phasing (right click, and save-as cnvHap_phasing.zip)
polyHap
polyHap is a program for phasing polyploids and copy number regions. See http://dx.doi.org/10.1186/1471-2105-9-513 for more details.
polyHap (right click, and save-as polyHap.zip)
AncesHC
AncesHC is a program for determining the haplotype structure of a population sample from genotype data, and then testing for association of these haplotypes with either a binary or continous outcome. See http://dx.doi.org/10.1093/bioinformatics/btn071 for more details.
metaMapper
metaMapper is a program for flexible, scalable GWAS meta-analysis and visualisation.
invertFREGENE
Software for simulating sequence level data with inversions. See http://dx.doi.org/10.1093/bioinformatics/btq029 for more details. Developed in conjunction with Clive Hoggart and Paul O'Reilly.
