Dr Lachlan J Coin

Contact details

Dr Lachlan J Coin

Research Fellow
Division of Epidemiology, Public Health and Primary Care

Tel: +44 (0)20 7594 1930
Email: Email address for Dr Lachlan J Coin

Dr Lachlan J Coin

I am a research fellow at Imperial College, working on various statistical and mathematical problems in genomics.    I am particularly interested in building mathematical models to identify genetic variants in high-throughput genomics data - including genotyping microarrays and next generation sequence data - with the ultimate aim of understanding the functional impact and evolutionary history of these variants.

Resume PDF Acrobat Document

Supplementary information Excel Spreadsheet  from paper "Pathway Analysis of GWAS Provides New Insights into Genetic Susceptibility to 3 Inflammatory Diseases"


Software:

cnvHap

cnvHap is a program for joint copy number genotyping and phasing, and integrates data from multiple platforms. It also carries out CN association. We presently have two concurrent releases of this software, each optimized for slightly different purposes:

  • optimised for CNV/SNP genotyping from intensity data, as well as carrying out association analyses

cnvHap_1.02 ZIP Archive(right click, and save-as cnvHap1.02.zip)

  • optimised for CNV phasing from pre-called CNV/SNP genotype data

cnvHap_phasing ZIP Archive (right click, and save-as cnvHap_phasing.zip)

 

polyHap

polyHap is a program for phasing polyploids and copy number regions. See http://dx.doi.org/10.1186/1471-2105-9-513 for more details.

polyHap ZIP Archive (right click, and save-as polyHap.zip)

 

AncesHC

AncesHC is a program for determining the haplotype structure of a population sample from genotype data, and then testing for association of these haplotypes with either a binary or continous outcome. See http://dx.doi.org/10.1093/bioinformatics/btn071 for more details.

 

AncesHC2009_1 ZIP Archive

metaMapper

metaMapper is a program for flexible, scalable GWAS meta-analysis and visualisation.

MetaMapper_1.01 ZIP Archive

invertFREGENE

Software for simulating sequence level data with inversions. See http://dx.doi.org/10.1093/bioinformatics/btq029 for more details. Developed in conjunction with Clive Hoggart and Paul O'Reilly.

 

 
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