Dr Lata Govada

 

Background

My initial qualifications are a Master’s degree in Pharmaceutical Chemistry from University of Madras, India. Before moving to England I was in the teaching profession. To seek a career change and move into the field of research, I continued my academic pursuit and completed a degree in Biomedical Sciences from University of Greenwich prior to embarking on a PhD programme at Imperial College under Professors Naomi Chayen and John Squire.

Since successful completion of my PhD in 2006, I am working as a Research Associate with Professor Naomi Chayen in Protein Crystallisation, developing new and improved methods to tackle the bottleneck of protein crystal growth.

Research Interests

• • Systematic studies on protein crystallisation.
• • Development of new and improved methods.
• • Separation of nucleation from growth for finding favourable crystallisation conditions.
• • Study of porous nucleating agents to aid crystal growth.
• • Employment of novel crystallisation vessels to enhance crystal quality.

Publications

Journals:

Structure/Processing Relationships in the Fabrication of Nanoporous Gold

Kertis, F., J. Snyder, L. Govada, S. Khurshid, N. Chayen and J. Erlebacher (2010). Jom 62(6): 50-56.

Carbon-nanotube-based materials for protein crystallization.

Asanithi P, Saridakis E, Govada L, Jurewicz I, Brunner EW, Ponnusamy R, Cleaver JA, Dalton AB, Chayen NE, Sear RP.

Attenuated total reflection-FT-IR spectroscopic imaging of protein crystallization.

Chan KL, Govada L, Bill RM, Chayen NE, Kazarian SG.

Anal Chem. 2009 May 15;81(10):3769-75.

ACS Appl Mater Interfaces. 2009 Jun;1(6):1203-10.

Crystallization by controlled evaporation leading to high resolution crystals of the C1 domain of cardiac Myosin Binding Protein-C

Lata Govada and Naomi E.Chayen

Crystal Growth & Design 2009, 9 (4), pp 1729–1732

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Crystal Structure of the C1 domain of Cardiac Myosin Binding Prtoein -C: Implications for Hypertrophic Cardiomyopathy
Lata Govada, Liz Carpenter, Paula C.A. da Fonseca, John R. Helliwell, Pierre Rizkallah, Emily Flashman, Naomi E. Chayen, Charles Redwood, John M. Squire
Journal of Molecular Biology, Volume 378, Issue 2, 25 April 2008, Pages 387-397

An investigation into the protonation states of the C1 domain of cardiac myosin-binding protein C
S.J. Fisher , J.R.Helliwell, S.Khurshid, L.govada, C.Redwood, J.M.Squire and N.E.Chayen
Acta Cryst. (2008). D64, 658-664 

Dynamic Screening Experiments to Maximize Hits for Crystallization
Khurshid, Sahir, Govada,Lata, and Chayen, Naomi E.
Cryst. Growth Des., 7, 11, 2171 - 2175, 2007

BookChapter:

Crystalization of Proteins: Principles and Methods in "Molecules: Nucleation, Aggregation and Crystallization.

Lata Govada (2009) Chapter 7: Ed Sedzik, J. and Riccio P. World Scientific Publishing

Workshops conducted

Septemeber 2010: International Conference on Crystallization of Biological Macromolecues 13, Dublin, Ireland

July2010: FEBS Advanced Course PLC10-015

October 2008: FEBS Advanced Course PLC 08-002

April 2008: International Conference on Crystallization of Biological Macromolecues 12, Cancun Mexico

August 2006: International Conference on Crystallization of Biological Macromolecues 12, Quebec Canada