Dr Elizabeth B Lightstone

Publications


Journals

  • Lightstone L. (Apr 2012). The landscape after LUNAR: rituximab's crater-filled path. Arthritis Rheum. 64:962-965. DOI.
  • International Consortium for Blood Pressure Genome-Wide Association Studies; Ehret GB; Munroe PB; Rice KM; Bochud M; Johnson AD; Chasman DI; Smith AV; et alTobin MD; Verwoert GC; Hwang SJ; Pihur V; Vollenweider P; O'Reilly PF; Amin N; Bragg-Gresham JL; Teumer A; Glazer NL; Launer L; Zhao JH; Aulchenko Y; Heath S; Sõber S; Parsa A; Luan J; Arora P; Dehghan A; Zhang F; Lucas G; Hicks AA; Jackson AU; Peden JF; Tanaka T; Wild SH; Rudan I; Igl W; Milaneschi Y; Parker AN; Fava C; Chambers JC; Fox ER; Kumari M; Go MJ; van der Harst P; Kao WH; Sjögren M; Vinay DG; Alexander M; Tabara Y; Shaw-Hawkins S; Whincup PH; Liu Y; Shi G; Kuusisto J; Tayo B; Seielstad M; Sim X; Nguyen KD; Lehtimäki T; Matullo G; Wu Y; Gaunt TR; Onland-Moret NC; Cooper MN; Platou CG; Org E; Hardy R; Dahgam S; Palmen J; Vitart V; Braund PS; Kuznetsova T; Uiterwaal CS; Adeyemo A; Palmas W; Campbell H; Ludwig B; Tomaszewski M; Tzoulaki I; Palmer ND; CARDIoGRAM consortium; CKDGen Consortium; KidneyGen Consortium; EchoGen consortium; CHARGE-HF consortium; Aspelund T; Garcia M; Chang YP; O'Connell JR; Steinle NI; Grobbee DE; Arking DE; Kardia SL; Morrison AC; Hernandez D; Najjar S; McArdle WL; Hadley D; Brown MJ; Connell JM; Hingorani AD; Day IN; Lawlor DA; Beilby JP; Lawrence RW; Clarke R; Hopewell JC; Ongen H; Dreisbach AW; Li Y; Young JH; Bis JC; Kähönen M; Viikari J; Adair LS; Lee NR; Chen MH; Olden M; Pattaro C; Bolton JA; Köttgen A; Bergmann S; Mooser V; Chaturvedi N; Frayling TM; Islam M; Jafar TH; Erdmann J; Kulkarni SR; Bornstein SR; Grässler J; Groop L; Voight BF; Kettunen J; Howard P; Taylor A; Guarrera S; Ricceri F; Emilsson V; Plump A; Barroso I; Khaw KT; Weder AB; Hunt SC; Sun YV; Bergman RN; Collins FS; Bonnycastle LL; Scott LJ; Stringham HM; Peltonen L; Perola M; Vartiainen E; Brand SM; Staessen JA; Wang TJ; Burton PR; Artigas MS; Dong Y; Snieder H; Wang X; Zhu H; Lohman KK; Rudock ME; Heckbert SR; Smith NL; Wiggins KL; Doumatey A; Shriner D; Veldre G; Viigimaa M; Kinra S; Prabhakaran D; Tripathy V; Langefeld CD; Rosengren A; Thelle DS; Corsi AM; Singleton A; Forrester T; Hilton G; McKenzie CA; Salako T; Iwai N; Kita Y; Ogihara T; Ohkubo T; Okamura T; Ueshima H; Umemura S; Eyheramendy S; Meitinger T; Wichmann HE; Cho YS; Kim HL; Lee JY; Scott J; Sehmi JS; Zhang W; Hedblad B; Nilsson P; Smith GD; Wong A; Narisu N; Stančáková A; Raffel LJ; Yao J; Kathiresan S; O'Donnell CJ; Schwartz SM; Ikram MA; Longstreth WT; Mosley TH; Seshadri S; Shrine NR; Wain LV; Morken MA; Swift AJ; Laitinen J; Prokopenko I; Zitting P; Cooper JA; Humphries SE; Danesh J; Rasheed A; Goel A; Hamsten A; Watkins H; Bakker SJ; van Gilst WH; Janipalli CS; Mani KR; Yajnik CS; Hofman A; Mattace-Raso FU; Oostra BA; Demirkan A; Isaacs A; Rivadeneira F; Lakatta EG; Orru M; Scuteri A; Ala-Korpela M; Kangas AJ; Lyytikäinen LP; Soininen P; Tukiainen T; Würtz P; Ong RT; Dörr M; Kroemer HK; Völker U; Völzke H; Galan P; Hercberg S; Lathrop M; Zelenika D; Deloukas P; Mangino M; Spector TD; Zhai G; Meschia JF; Nalls MA; Sharma P; Terzic J; Kumar MV; Denniff M; Zukowska-Szczechowska E; Wagenknecht LE; Fowkes FG; Charchar FJ; Schwarz PE; Hayward C; Guo X; Rotimi C; Bots ML; Brand E; Samani NJ; Polasek O; Talmud PJ; Nyberg F; Kuh D; Laan M; Hveem K; Palmer LJ; van der Schouw YT; Casas JP; Mohlke KL; Vineis P; Raitakari O; Ganesh SK; Wong TY; Tai ES; Cooper RS; Laakso M; Rao DC; Harris TB; Morris RW; Dominiczak AF; Kivimaki M; Marmot MG; Miki T; Saleheen D; Chandak GR; Coresh J; Navis G; Salomaa V; Han BG; Zhu X; Kooner JS; Melander O; Ridker PM; Bandinelli S; Gyllensten UB; Wright AF; Wilson JF; Ferrucci L; Farrall M; Tuomilehto J; Pramstaller PP; Elosua R; Soranzo N; Sijbrands EJ; Altshuler D; Loos RJ; Shuldiner AR; Gieger C; Meneton P; Uitterlinden AG; Wareham NJ; Gudnason V; Rotter JI; Rettig R; Uda M; Strachan DP; Witteman JC; Hartikainen AL; Beckmann JS; Boerwinkle E; Vasan RS; Boehnke M; Larson MG; Järvelin MR; Psaty BM; Abecasis GR; Chakravarti A; Elliott P; van Duijn CM; Newton-Cheh C; Levy D; Caulfield MJ; Johnson T. (6 Oct 2011). Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 478:103-109. DOI.
  • Wilkinson E; Randhawa G; Farrington K; Greenwood R; Feehally J; Choi P; Lightstone L. (Mar 2011). Lack of awareness of kidney complications despite familiarity with diabetes: a multi-ethnic qualitative study. J Ren Care. 37:2-11. DOI.
  • Hall M; Wilkinson E; Chadna S; Farrington K; Frankel A; Greenwood R; Lightstone L; Roderick P; et alWillis J; Feehally J; Randhawa G. (1 Nov 2010). Ethnic differences in renal referral patterns following national CKD guidelines. CLINICAL NEPHROLOGY. 74:S152-S153.
  • Chambers JC; Zhang W; Lord GM; van der Harst P; Lawlor DA; Sehmi JS; Gale DP; Wass MN; et alAhmadi KR; Bakker SJ; Beckmann J; Bilo HJ; Bochud M; Brown MJ; Caulfield MJ; Connell JM; Cook HT; Cotlarciuc I; Davey Smith G; de Silva R; Deng G; Devuyst O; Dikkeschei LD; Dimkovic N; Dockrell M; Dominiczak A; Ebrahim S; Eggermann T; Farrall M; Ferrucci L; Floege J; Forouhi NG; Gansevoort RT; Han X; Hedblad B; Homan van der Heide JJ; Hepkema BG; Hernandez-Fuentes M; Hypponen E; Johnson T; de Jong PE; Kleefstra N; Lagou V; Lapsley M; Li Y; Loos RJ; Luan J; Luttropp K; Maréchal C; Melander O; Munroe PB; Nordfors L; Parsa A; Peltonen L; Penninx BW; Perucha E; Pouta A; Prokopenko I; Roderick PJ; Ruokonen A; Samani NJ; Sanna S; Schalling M; Schlessinger D; Schlieper G; Seelen MA; Shuldiner AR; Sjögren M; Smit JH; Snieder H; Soranzo N; Spector TD; Stenvinkel P; Sternberg MJ; Swaminathan R; Tanaka T; Ubink-Veltmaat LJ; Uda M; Vollenweider P; Wallace C; Waterworth D; Zerres K; Waeber G; Wareham NJ; Maxwell PH; McCarthy MI; Jarvelin MR; Mooser V; Abecasis GR; Lightstone L; Scott J; Navis G; Elliott P; Kooner JS. (May 2010). Genetic loci influencing kidney function and chronic kidney disease. Nat Genet. 42:373-375. DOI.
  • Lightstone L. (May 2010). Lupus nephritis: where are we now?. Curr Opin Rheumatol. 22:252-256. DOI.
  • Pepper R; Griffith M; Kirwan C; Levy J; Taube D; Pusey C; Lightstone L; Cairns T. (Dec 2009). Rituximab is an effective treatment for lupus nephritis and allows a reduction in maintenance steroids. Nephrol Dial Transplant. 24:3717-3723. DOI.
  • Gordon C; Jayne D; Pusey C; Adu D; Amoura Z; Aringer M; Ballerin J; Cervera R; et alCalvo-Alen J; Chizzolini C; Dayer JM; Doria A; Ferrario F; Floege J; Guillevin L; Haubitz M; Hiepe F; Houssiau F; Lesavre P; Lightstone L; Meroni PL; Meyer O; Moulin B; O'Reilly K; Praga M; Schulze-Koops H; Sinico RA; Smith KGC; Tincani A; Vasconcelos C; Hughes G. (1 Mar 2009). European consensus statement on the terminology used in the management of lupus glomerulonephritis. LUPUS. 18:257-263. Author weblink DOI.
  • Yates J; Whittington A; Mitchell P; Lechler RI; Lightstone L; Lombardi G. (1 Jul 2008). Natural regulatory T cells: number and function are normal in the majority of patients with lupus nephritis. CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 153:44-55. Author weblink DOI.
  • Laing CM; Roberts R; Lightstone L; Graham A; Cook TH; Summers S; Pusey CD. (28 Jul 2007). A patient with suspected miscarriage is found to have hypertension, renal failure, and thrombocytopenia: case outcome. BMJ. 335:205-206. DOI.
  • Laing CM; Roberts R; Lightstone L; Graham A; Cook TH; Summers S; Pusey CD. (7 Jul 2007). A patient with suspected miscarriage is found to have hypertension, renal failure, and thrombocytopenia: case progression. BRITISH MEDICAL JOURNAL. 335:44-44. Author weblink DOI.
  • Laing CM; Roberts R; Lightstone L; Graham A; Cook TH; Summers S; Pusey CD. (30 Jun 2007). Interactive case report - A patient with suspected miscarriage is found to have hypertension, renal failure, and thrombocytopenia: case presentation. BRITISH MEDICAL JOURNAL. 334:1372-1372. Author weblink DOI.
  • Mosley K; Tam FW; Edwards RJ; Crozier J; Pusey CD; Lightstone L. (Dec 2006). Urinary proteomic profiles distinguish between active and inactive lupus nephritis. Rheumatology (Oxford). 45:1497-1504. DOI.
  • Laing CM; Roberts R; Summers S; Friedland JS; Lightstone L; Unwin RJ. (May 2006). Distal renal tubular acidosis in association with HIV infection and AIDS. Nephrol Dial Transplant. 21:1420-1422. DOI.
  • Feehally J; Harrington JT; Bello AK; Gorovich A; Pierides A; Pusey C; Tomson C; Winearls CG; et alWilliams G; Duffield J; Lightstone L; World MJ; Naish P; Feest T. (1 Jul 2005). Ethnicity and renal disease. KIDNEY INTERNATIONAL. 68:414-424. Author weblink.
  • Chadha S; Miller K; Farwell L; Lightstone LB; Daly MJ; Rioux JD; Vyse TJ. (May 2005). Haplotype structure of TNFRSF5-TNFSF5 (CD40-CD40L) and association analysis in systemic lupus erythematosus. Eur J Hum Genet. 13:669-676. DOI.
  • de Swiet M; Lightstone L. (1 Feb 2004). Glomerular endotheliosis in normal pregnancy and pre-eclampsia. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY. 111:191-192. Author weblink DOI.
  • Salama AD; Chaudhry AN; Holthaus KA; Mosley K; Kalluri R; Sayegh MH; Lechler RI; Pusey CD; et alLightstone L. (Nov 2003). Regulation by CD25+ lymphocytes of autoantigen-specific T-cell responses in Goodpasture's (anti-GBM) disease. Kidney Int. 64:1685-1694. DOI.
  • Lightstone L. (Feb 2003). Preventing renal disease: the ethnic challenge in the United Kingdom. Kidney Int Suppl. S135-S138.
  • Salama AD; Chaudhry A; Sayegh MH; Lechler RI; Pusey CD; Lightstone L. (1 Sep 2002). The role of CD25+regulatory cells in restoring tolerance in autoimmune anti-GBM (Goodpasture's) disease. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 13:664A-664A. Author weblink.
  • Salama AD; Dougan T; Levy JB; Cook HT; Morgan SH; Naudeer S; Maidment G; George AJ; et alEvans D; Lightstone L; Pusey CD. (Jun 2002). Goodpasture's disease in the absence of circulating anti-glomerular basement membrane antibodies as detected by standard techniques. Am J Kidney Dis. 39:1162-1167. DOI.
  • Lightstone L. (27 May 2002). End-stage renal failure in Indo-Asians in the UK: A double whammy. TRANSPLANTATION. 73:1533-1534. Author weblink DOI.
  • Moore DA; Lightstone L; Javid B; Friedland JS. (Jan 2002). High rates of tuberculosis in end-stage renal failure: the impact of international migration. Emerg Infect Dis. 8:77-78.
  • Lightstone L. (2002). Renal disease in minority populations. Br J Renal Med. 3, 7:9-11.
  • Salama AD; Levy JB; Lightstone L; Pusey CD. (15 Sep 2001). Goodpasture's disease. Lancet. 358:917-920. DOI.
  • Salama AD; Chaudhry AN; Ryan JJ; Eren E; Levy JB; Pusey CD; Lightstone L; Lechler RI. (Sep 2001). In Goodpasture's disease, CD4(+) T cells escape thymic deletion and are reactive with the autoantigen alpha3(IV)NC1. J Am Soc Nephrol. 12:1908-1915.
  • Glynne PA; Lightstone L. (Jul 2001). Acute renal failure. Clin Med. 1:266-273.
  • Dupont P; Jackson J; Warrens A; Lightstone L. (Apr 2001). Life-threatening thrombosis 18 years after first presentation of primary antiphospholipid antibody syndrome. Nephrol Dial Transplant. 16:843-845.
  • Dupont PJ; Lightstone L; Clutterbuck EJ; Gaskin G; Pusey CD; Cook T; Warrens AN. (28 Oct 2000). Lesson of the week: cholesterol emboli syndrome. BMJ. 321:1065-1067.
  • Glynne P; Salama A; Chaudhry A; Swirsky D; Lightstone L. (Jan 1999). Quinine-induced immune thrombocytopenic purpura followed by hemolytic uremic syndrome. Am J Kidney Dis. 33:133-137.
  • Lightstone L; Salama A; Malik A; Fullwood Y. (1 Oct 1997). Resident renal cell populations may be able to function as antigen presenting cells to CD4+ T cells. KIDNEY INTERNATIONAL. 52:1125-1125. Author weblink.
  • Lightstone L; Glynne P; Salama A. (1 Sep 1997). Quinine-dependent anti-glycoprotein antibodies causing thrombocytopenia and hemolytic uremic syndrome (HUS). JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 8:A2136-A2136. Author weblink.
  • Lightstone L; Hargreaves R; Bobek G; Peterson M; Aichinger G; Lombardi G; Lechler R. (27 May 1997). In the absence of the invariant chain, HLA-DR molecules display a distinct array of peptides which is influenced by the presence or absence of HLA-DM. Proc Natl Acad Sci U S A. 94:5772-5777.
  • Bobek G; Hargreaves R; Lombardi G; Lechler R; Lightstone L. (1 Nov 1996). Discordant expression of invariant chain & HLA-DM allows presentation of neo-epitopes by DR1 molecules. IMMUNOLOGY. 89:ORB16-ORB16. Author weblink.
  • Lechler R; Aichinger G; Lightstone L. (Jun 1996). The endogenous pathway of MHC class II antigen presentation. Immunol Rev. 151:51-79.
  • Lombardi G; Hargreaves R; Sidhu S; Imami N; Lightstone L; Fuller-Espie S; Ritter M; Robinson P; et alTarnok A; Lechler R. (15 Apr 1996). Antigen presentation by T cells inhibits IL-2 production and induces IL-4 release due to altered cognate signals. J Immunol. 156:2769-2775.
  • Lightstone L; Bobek G; Hargreaves R; Lombardi G; Lechler R. (15 Apr 1996). HLA-DM influences MHC class II peptide occupancy independently of the II chain. HUMAN IMMUNOLOGY. 47:P514-P514.
  • Lechler R; Hargreaves R; Bobek G; Lombardi G; Stauss H; Lightstone L. (15 Apr 1996). In the absence of Ii, MHC class II molecules display a distinct set of self peptides. HUMAN IMMUNOLOGY. 47:O71-O71. Author weblink.
  • LIGHTSTONE L; BOBEK G; PETERSON M; LOMBARDI G; STAUSS H; LECHLER R. (1 Sep 1995). THE INFLUENCE OF AN INFLAMMATORY MILIEU ON ANTIGEN PRESENTATION - A POSSIBLE ROUTE TO AUTOIMMUNITY. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 6:840-840. Author weblink.
  • LIGHTSTONE L. (1 Aug 1995). END-STAGE RENAL-FAILURE IN INDO-ASIANS. QJM-MONTHLY JOURNAL OF THE ASSOCIATION OF PHYSICIANS. 88:597-597. Author weblink.
  • Pihlgren M; Lightstone L; Mamalaki C; Rimon G; Kioussis D; Marvel J. (Jun 1995). Expression in vivo of CD45RA, CD45RB and CD44 on T cell receptor-transgenic CD8+ T cells following immunization. Eur J Immunol. 25:1755-1759. DOI.
  • Lightstone L; Rees AJ; Tomson C; Walls J; Winearls CG; Feehally J. (Mar 1995). High incidence of end-stage renal disease in Indo-Asians in the UK. QJM. 88:191-195.
  • Lightstone L; Marvel J. (Nov 1993). CD45RA+ T cells: not simple virgins. Clin Sci (Lond). 85:515-519.
  • Lightstone EB; Wyllie D; Marvel J. (Sep 1991). In the mouse the maturation stage of the peripheral CD4+ CD45RA+ subset is different from that of the CD8+ CD45RA+ subset. Eur J Immunol. 21:2161-2165. DOI.
  • Lightstone EB; Marvel J. (Dec 1990). CD45RA is detected in all thymocyte subsets defined by CD4 and CD8 by using three-colour flow cytometry. Immunology. 71:467-472.
  • FISHER AG; GOFF LK; LIGHTSTONE L; MARVEL J; MITCHISON NA; POIRIER G; STAUSS H; ZAMOYSKA R. (1 Jan 1989). PROBLEMS IN THE PHYSIOLOGY OF CLASS-I AND CLASS-II MHC MOLECULES, AND OF CD45. COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY. 54:667-674. Author weblink.
  • Fisher AG; Goff LK; Lightstone L; Marvel J; Mitchison NA; Poirier G; Stauss H; Zamoyska R. (1989). Problems in the physiology of class I and class II MHC molecules, and of CD45. Cold Spring Harb Symp Quant Biol. 54 Pt 2:667-674.

Books

  • Lightstone EB. Friedland JS (ed); Lightstone EB (ed). Infection and Immunity. Martin Dunitz, 11 New Fetter Lane, London EC4P 4EE (2003). Author weblink.
  • Lightstone L; Woolnough L. Preventing kidney disease: the ethnic challenge in Brent. National Kidney Research Fund (2002).
  • Lightstone E. Preventing kidney disease: the ethnic challenge. National Kidney Research Fund, Peterborough, England (2001).

Chapters in books

  • Lightstone L. Postpartum follow up of antenatally defined renal problems. In Renal Disease in Pregnancy. 1st. Davison JM (ed); Nelson-Piercy C (ed); Kehoe S (ed); Baker P (ed). RCOG, London (Jun 2008). Publisher weblink.
  • Lightstone L. Preconception counselling and risk assessment - general overview. In Renal Disease in Pregnancy. 1st. Davison JM (ed); Nelson-Piercy C (ed); Kehoe S (ed); Baker P (ed). RCOG, London (Jun 2008). Publisher weblink.
  • Cook T. SLE - Renal Involvement. In The Kidney in Systemic Autoimmune Diseases. 1st, 7. Mason J (ed); Pusey C (ed); Asherson R (ed). Elsevier, UK (Dec 2007). Publisher weblink.
  • Lightstone L. How to manage renal disease in pregnancy. In Horizons in Medicine 16 Updates on major clinical advances. 261-270. Franklyn J (ed). Royal College of Physicians of London, London (Aug 2004).

Conferences

  • Chusney GD; Lightstone L; Cairns T; Lee J. Quantification of hydroxychloroquine in whole blood samples by LC-MS/MS. 12th International Congress of Therapeutic Drug Monitoring and Clinical Toxicology, 2 Oct 2011 - 6 Oct 2011. 33:500-500. LIPPINCOTT WILLIAMS & WILKINS (1 Aug 2011).
  • Chusney GD; Bramham K; Nelson-Piercy C; Rosser C; James A; Cairns T; Lightstone L; Lee J. Tacrolimus monitoring during breastfeeding in neonates of transplant recipients. 12th International Congress of Therapeutic Drug Monitoring and Clinical Toxicology, 2 Oct 2011 - 6 Oct 2011. 33:476-476. LIPPINCOTT WILLIAMS & WILKINS (1 Aug 2011).
  • FISHER AG; GOFF LK; LIGHTSTONE L; MARVEL J; MITCHISON NA; POIRIER G; STAUSS H; ZAMOYSKA R. PROBLEMS IN THE PHYSIOLOGY OF CLASS-I AND CLASS-II MHC MOLECULES, AND OF CD45. 3RD SYMP ON IMMUNOLOGICAL RECOGNITION, 1989. 54:667-674. COLD SPRING HARBOR LABORATORY PRESS (1 Jan 1989).
  • Lim E; Lightstone L; Chambers J; Roderick P; Mullee M; Kooner J. Chronic kidney disease as a cardiovascular risk factor in UK Indian Asians compared to UK Northern Europeans: The London Life Sciences Prospective Population Study (LOLIPOP). Annual Scientific Conference of the British-Society-Promoting-Cardiovascular-Health, 24 Apr 2006 - 27 Apr 2006. 92:A12-A12. B M J PUBLISHING GROUP (1 May 2006). Author weblink.
  • Barhamein MY; Tam FWK; Lai PC; Chaudhry A; Thompson M; Pusey CD; Lightstone L. Urinary monocyte chemoattractant protein-1 (uMCP-1) is more useful than PDGF-BB or IFN-gamma for monitoring activity of lupus nephritis (LN). 36th Annual Meeting of the American-Society-of-Nephrology. 14:148A-148A. (Nov 2003).
  • Lightstone L. Preventing renal disease: The ethnic challenge in the United Kingdom. World Congress of Nephrology, 19 Oct 2001 - 20 Oct 2001. 63:135-138. BLACKWELL PUBLISHING INC (1 Feb 2003). Author weblink DOI.
  • Lightstone L. Preventing Renal Disease: The NKRF ABLE project. Ethnicity and Renal Failure: disparity or diversity?, Oct 2003. SouthWest Thames Renal Research Institute, St Helier Hospital, Carshalton, Surrey (2003).
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