Professor Lefkos Middleton

Publications


Journals

  • Breen G; Webb BT; Butler AW; van den Oord EJCG; Tozzi F; Craddock N; Gill M; Korszun A; et alMaier W; Middleton L; Mors O; Owen MJ; Cohen-Woods S; Perry J; Galwey NW; Upmanyu R; Craig I; Lewis CM; Ng M; Brewster S; Preisig M; Rietschel M; Jones L; Knight J; Rice J; Muglia P; Farmer AE; McGuffin P. (1 Aug 2011). A Genome-Wide Significant Linkage for Severe Depression on Chromosome 3: The Depression Network Study. AMERICAN JOURNAL OF PSYCHIATRY. 168:840-847. DOI.
  • Butler AW; Breen G; Tozzi F; Craddock N; Gill M; Korszun A; Maier W; Middleton LT; et alMors O; Owen MJ; Perry J; Preisig M; Rice JP; Rietschel M; Jones L; Farmer AE; Lewis CM; McGuffin P. (1 Dec 2010). A Genomewide Linkage Study on Suicidality in Major Depressive Disorder Confirms Evidence for Linkage to 2p12. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS. 153B:1465-1473. Author weblink DOI.
  • Spencer JP; Middleton LJ; Davies CH. (1 Nov 2010). Investigation into the efficacy of the acetylcholinesterase inhibitor, donepezil, and novel procognitive agents to induce gamma oscillations in rat hippocampal slices. NEUROPHARMACOLOGY. 59:437-443. Author weblink DOI.
  • Jasinska-Myga B; Kachergus J; Vilarino-Gueell C; Wider C; Soto-Ortolaza AI; Kefi M; Middleton LT; Ishihara-Paul L; et alGibson RA; Amouri R; Ben Yahmed S; Ben Sassi S; Zouari M; El Euch G; Ross OA; Hentati F; Farrer MJ. (15 Oct 2010). Comprehensive Sequencing of the LRRK2 Gene in Patients with Familial Parkinson's Disease from North Africa. MOVEMENT DISORDERS. 25:2052-2058. DOI.
  • Ozcelik T; Kanaan M; Avraham KB; Yannoukakos D; Megarbane A; Tadmouri GO; Middleton L; Romeo G; et alKing M-C; Levy-Lahad E. (1 Aug 2010). Collaborative genomics for human health and cooperation in the Mediterranean region. NATURE GENETICS. 42:641-645. Author weblink DOI.
  • Kasperaviciute D; Catarino CB; Heinzen EL; Depondt C; Cavalleri GL; Caboclo LO; Tate SK; Jamnadas-Khoda J; et alChinthapalli K; Clayton LMS; Shianna KV; Radtke RA; Mikati MA; Gallentine WB; Husain AM; Alhusaini S; Leppert D; Middleton LT; Gibson RA; Johnson MR; Matthews PM; Hosford D; Heuser K; Amos L; Ortega M; Zumsteg D; Wieser H-G; Steinhoff BJ; Kraermer G; Hansen J; Dorn T; Kantanen A-M; Gjerstad L; Peuralinna T; Hernandez DG; Eriksson KJ; Kalviainen RK; Doherty CP; Wood NW; Pandolfo M; Duncan JS; Sander JW; Delanty N; Goldstein DB; Sisodiya SM. (1 Jul 2010). Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study. BRAIN. 133:2136-2147. DOI.
  • Heinzen EL; Radtke RA; Urban TJ; Cavalleri GL; Depondt C; Need AC; Walley NM; Nicoletti P; et alGe D; Catarino CB; Duncan JS; Kasperaviciute D; Tate SK; Caboclo LO; Sander JW; Clayton L; Linney KN; Shianna KV; Gumbs CE; Smith J; Cronin KD; Maia JM; Doherty CP; Pandolfo M; Leppert D; Middleton LT; Gibson RA; Johnson MR; Matthews PM; Hosford D; Kalviainen R; Eriksson K; Kantanen A-M; Dorn T; Hansen J; Kraemer G; Steinhoff BJ; Wieser H-G; Zumsteg D; Ortega M; Wood NW; Huxley-Jones J; Mikati M; Gallentine WB; Husain AM; Buckley PG; Stallings RL; Podgoreanu MV; Delanty N; Sisodiya SM; Goldstein DB. (14 May 2010). Rare Deletions at 16p13.11 Predispose to a Diverse Spectrum of Sporadic Epilepsy Syndromes. AMERICAN JOURNAL OF HUMAN GENETICS. 86:707-718. Author weblink DOI.
  • Liu JZ; Tozzi F; Waterworth DM; Pillai SG; Muglia P; Middleton L; Berrettini W; Knouff CW; et alYuan X; Waeber G; Vollenweider P; Preisig M; Wareham NJ; Zhao JH; Loos RJF; Barroso I; Khaw K-T; Grundy S; Barter P; Mahley R; Kesaniemi A; McPherson R; Vincent JB; Strauss J; Kennedy JL; Farmer A; McGuffin P; Day R; Matthews K; Bakke P; Gulsvik A; Lucae S; Ising M; Brueckl T; Horstmann S; Wichmann H-E; Rawal R; Dahmen N; Lamina C; Polasek O; Zgaga L; Huffman J; Campbell S; Kooner J; Chambers JC; Burnett MS; Devaney JM; Pichard AD; Kent KM; Satler L; Lindsay JM; Waksman R; Epstein S; Wilson JF; Wild SH; Campbell H; Vitart V; Reilly MP; Li M; Qu L; Wilensky R; Matthai W; Hakonarson HH; Rader DJ; Franke A; Wittig M; Schaefer A; Uda M; Terracciano A; Xiao X; Busonero F; Scheet P; Schlessinger D; St Clair D; Rujescu D; Abecasis GR; Grabe HJ; Teumer A; Voelzke H; Petersmann A; John U; Rudan I; Hayward C; Wright AF; Kolcic I; Wright BJ; Thompson JR; Balmforth AJ; Hall AS; Samani NJ; Anderson CA; Ahmad T; Mathew CG; Parkes M; Satsangi J; Caulfield M; Munroe PB; Farrall M; Dominiczak A; Worthington J; Thomson W; Eyre S; Barton A; Mooser V; Francks C; Marchini J. (1 May 2010). Meta-analysis and imputation refines the association of 15q25 with smoking quantity. NATURE GENETICS. 42:436-U75. Author weblink DOI.
  • Heinzen EL; Radtke RA; Urban TJ; Cavalleri GL; Depondt C; Need AC; Walley NM; Nicoletti P; et alGe D; Catarino CB; Duncan JS; Kasperaviciūte D; Tate SK; Caboclo LO; Sander JW; Clayton L; Linney KN; Shianna KV; Gumbs CE; Smith J; Cronin KD; Maia JM; Doherty CP; Pandolfo M; Leppert D; Middleton LT; Gibson RA; Johnson MR; Matthews PM; Hosford D; Kälviäinen R; Eriksson K; Kantanen AM; Dorn T; Hansen J; Krämer G; Steinhoff BJ; Wieser HG; Zumsteg D; Ortega M; Wood NW; Huxley-Jones J; Mikati M; Gallentine WB; Husain AM; Buckley PG; Stallings RL; Podgoreanu MV; Delanty N; Sisodiya SM; Goldstein DB. (14 May 2010). Rare deletions at 16p13.11 predispose to a diverse spectrum of sporadic epilepsy syndromes. Am J Hum Genet. 86:707-718. DOI.
  • Nishioka K; Kefi M; Jasinska-Myga B; Wider C; Vilariño-Güell C; Ross OA; Heckman MG; Middleton LT; et alIshihara-Paul L; Gibson RA; Amouri R; Ben Yahmed S; Ben Sassi S; Zouari M; El Euch G; Farrer MJ; Hentati F. (Apr 2010). A comparative study of LRRK2, PINK1 and genetically undefined familial Parkinson's disease. J Neurol Neurosurg Psychiatry. 81:391-395. DOI.
  • Domenici E; Wille DR; Tozzi F; Prokopenko I; Miller S; McKeown A; Brittain C; Rujescu D; et alGiegling I; Turck CW; Holsboer F; Bullmore ET; Middleton L; Merlo-Pich E; Alexander RC; Muglia P. (11 Feb 2010). Plasma Protein Biomarkers for Depression and Schizophrenia by Multi Analyte Profiling of Case-Control Collections. PLOS ONE. 5. DOI.
  • Ball HA; Samaan Z; Brewster S; Craddock N; Gill M; Korszun A; Maier W; Middleton L; et alMors O; Owen MJ; Perry J; Preisig M; Rice J; Rietschel M; Jones L; Jones I; Farmer AE; McGuffin P. (1 Aug 2009). Depression, migraine with aura and migraine without aura: their familiality and interrelatedness. CEPHALALGIA. 29:848-854. Author weblink DOI.
  • Scott LJ; Muglia P; Kong XQ; Guan W; Flickinger M; Upmanyu R; Tozzi F; Li JZ; et alBurmeisterg M; Absher D; Thompson RC; Francks C; Meng F; Antoniades A; Southwick AM; Schatzberg AF; Bunney WE; Barchask JD; Jones EG; Day R; Matthews K; McGuffin P; Strauss JS; Kennedy JL; Middleton L; Roses AD; Watson SJ; Vincent JB; Myers RM; Farmer AE; Akil H; Burns DK; Boehnke M. (5 May 2009). Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 106:7501-7506. Author weblink DOI.
  • Lin X; Song K; Lim N; Yuan X; Johnson T; Abderrahmani A; Vollenweider P; Stirnadel H; et alSundseth SS; Lai E; Burns DK; Middleton LT; Roses AD; Matthews PM; Waeber G; Cardon L; Waterworth DM; Mooser V. (Apr 2009). Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score--the CoLaus Study. Diabetologia. 52:600-608. DOI.
  • Gallo V; Bueno-de-Mesquita HB; Vermeulen R; Andersen PM; Kyrozis A; Linseisen J; Kaaks R; Allen NE; et alRoddam AW; Boshuizen HC; Peeters PH; Palli D; Mattiello A; Sieri S; Tumino R; Jimenez-Martin J-M; Tormo Diaz MJ; Rodriguez Suarez L; Trichopoulou A; Agudo A; Arriola L; Barricante-Gurrea A; Bingham S; Khaw K-T; Manjer J; Lindkvist B; Overvad K; Bach FW; Tjonneland A; Olsen A; Bergmann MM; Boeing H; Clavel-Chapelon F; Lund E; Hallmans G; Middleton L; Vineis P; Riboli E. (1 Apr 2009). Smoking and Risk for Amyotrophic Lateral Sclerosis: Analysis of the EPIC Cohort. ANNALS OF NEUROLOGY. 65:378-385. Author weblink DOI.
  • Preisig M; Waeber G; Vollenweider P; Bovet P; Rothen S; Vandeleur C; Guex P; Middleton L; et alWaterworth D; Mooser V; Tozzi F; Muglia P. (17 Mar 2009). The PsyCoLaus study: methodology and characteristics of the sample of a population-based survey on psychiatric disorders and their association with genetic and cardiovascular risk factors. BMC PSYCHIATRY. 9. Author weblink DOI.
  • Vilariño-Güell C; Soto AI; Lincoln SJ; Ben Yahmed S; Kefi M; Heckman MG; Hulihan MM; Chai H; et alDiehl NN; Amouri R; Rajput A; Mash DC; Dickson DW; Middleton LT; Gibson RA; Hentati F; Farrer MJ. (Mar 2009). ATP13A2 variability in Parkinson disease. Hum Mutat. 30:406-410. DOI.
  • Need AC; Ge D; Weale ME; Maia J; Feng S; Heinzen EL; Shianna KV; Yoon W; et alKasperaviciute D; Gennarelli M; Strittmatter WJ; Bonvicini C; Rossi G; Jayathilake K; Cola PA; McEvoy JP; Keefe RSE; Fisher EMC; St. Jean PL; Giegling I; Hartmann AM; Moeller H-J; Ruppert A; Fraser G; Crombie C; Middleton LT; St. Clair D; Roses AD; Muglia P; Francks C; Rujescu D; Meltzer HY; Goldstein DB. (1 Feb 2009). A Genome-Wide Investigation of SNPs and CNVs in Schizophrenia. PLOS GENETICS. 5. Author weblink DOI.
  • Muglia P; Tozzi F; Galwey NW; Francks C; Upmanyu R; Kong XQ; Antoniades A; Domenici E; et alPerry J; Rothen S; Vandeleur CL; Mooser V; Waeber G; Vollenweider P; Preisig M; Lucae S; Müller-Myhsok B; Holsboer F; Middleton LT; Roses AD. (Jun 2010). Genome-wide association study of recurrent major depressive disorder in two European case-control cohorts. Mol Psychiatry. 15:589-601. DOI.
  • Ishihara-Paul L; Hulihan MM; Kachergus J; Upmanyu R; Warren L; Amouri R; Elango R; Prinjha RK; et alSoto A; Kefi M; Zouari M; Sassi SB; Yahmed SB; El Euch-Fayeche G; Matthews PM; Middleton LT; Gibson RA; Hentati F; Farrer MJ. (16 Sep 2008). PINK1 mutations and parkinsonism. NEUROLOGY. 71:896-902. Author weblink DOI.
  • Hulihan MM; Ishihara-Paul L; Kochergus J; Warren L; Amouri R; Elango R; Prinjha RK; Upmanyu R; et alKefi M; Zouari M; Ben Sassi S; Ben Yahmed S; El Euch-Fayeche G; Matthews PM; Middleton LT; Gibson RA; Hentati F; Farrer MJ. (1 Jul 2008). LRRK2 Gly2019Ser penetrance in Arab-Berber patients from Tunisia: a case-control genetic study. LANCET NEUROLOGY. 7:591-594. Author weblink DOI.
  • Tozzi F; Prokopenko I; Perry JD; Kennedy JL; McCarthy AD; Holsboer F; Berrettini W; Middleton LT; et alChilcoat HD; Muglia P. (May 2008). Family history of depression is associated with younger age of onset in patients with recurrent depression. Psychol Med. 38:641-649. DOI.
  • Nicolaou P; Georghiou A; Votsi C; Middleton LT; Zamba-Papanicolaou E; Christodoulou K. (2008). A novel c.5308_5311delGAGA mutation in Senataxin in a Cypriot family with an autosomal recessive cerebellar ataxia. BMC Med Genet. 9:28. DOI.
  • Isihara PL; Hulihan M; Kachergus J; Middleton L; Roses AD. Candidate single Nucleotide Polymorphism from a Genome- Wide Association Study of Alzheimer's Disease. Archives of Neurology (In press).
  • Pillai SG; Chiano MN; White NJ; Speer M; Barnes KC; Carlsen K; Gerritsen J; Helms P; et alLenney W; Silverman M; Sly P; Sundy J; Tsanakas J; von Berg A; Whyte M; Varsani S; Skelding P; Hauser M; Vance J; Pericak-Vance M; Burns DK; Middleton LT; Brewster SR; Anderson WH; Riley JH. (1 Jun 2007). A genome-wide search for linkage to asthma phenotypes in the genetics of asthma international network families: evidence for a major susceptibility locus on chromosome 2p (vol 14, pg 307, 2006). EUROPEAN JOURNAL OF HUMAN GENETICS. 15:714-714. Author weblink DOI.
  • Webb BT; van den Oord E; Akkari A; Wilton S; Ly T; Duff R; Barnes KC; Carlsen K; et alGerritsen J; Lenney W; Silverman M; Sly P; Sundy J; Tsanakas J; von Berg A; Whyte M; Blumenthal M; Vestbo J; Middleton L; Helms PJ; Anderson WH; Pillai SG. (Mar 2007). Quantitative linkage genome scan for atopy in a large collection of Caucasian families. Hum Genet. 121:83-92. DOI.
  • Ishihara L; Gibson RA; Warren L; Amouri R; Lyons K; Wielinski C; Hunter C; Swartz JE; et alElango R; Akkari PA; Leppert D; Surh L; Reeves KH; Thomas S; Ragone L; Hattori N; Pahwa R; Jankovic J; Nance M; Freeman A; Gouider-Khouja N; Kefi M; Zouari M; Ben Sassi S; Ben Yahmed S; El Euch-Fayeche G; Middleton L; Burn DJ; Watts RL; Hentati F. (Jan 2007). Screening for Lrrk2 G2019S and clinical comparison of Tunisian and North American Caucasian Parkinson's disease families. Mov Disord. 22:55-61. DOI.
  • Ishihara L; Warren L; Gibson R; Amouri R; Lesage S; Durr A; Tazir M; Wszolek ZK; et alUitti RJ; Nichols WC; Griffith A; Hattori N; Leppert D; Watts R; Zabetian CP; Foroud TM; Farrer MJ; Brice A; Middleton L; Hentati F. (1 Sep 2006). Clinical features of Parkinson disease patients with homozygous leucine-rich repeat kinase 2 G2019S mutations. ARCHIVES OF NEUROLOGY. 63:1250-1254. Author weblink DOI.
  • Pillai SG; Chiano MN; White NJ; Speer M; Barnes KC; Carlsen K; Gerritsen J; Helms P; et alLenney W; Silverman M; Sly P; Sundy J; Tsanakas J; von Berg A; Whyte M; Varsani S; Skelding P; Hauser M; Vance J; Pericak-Vance M; Burns DK; Middleton LT; Brewster SR; Anderson WH; Riley JH. (Mar 2006). A genome-wide search for linkage to asthma phenotypes in the genetics of asthma international network families: evidence for a major susceptibility locus on chromosome 2p. Eur J Hum Genet. 14:307-316. DOI.
  • Van den Oord EJCG; Rujescu D; Robles JR; Giegling I; Birrell C; Bukszar J; Murrelle L; Moller HJ; et alMiddleton L; Muglia P. (28 Feb 2006). Factor structure and external validity of the PANSS revisited. SCHIZOPHRENIA RESEARCH. 82:213-223. Author weblink DOI.
  • McGuffin P; Knight J; Breen G; Brewster S; Boyd PR; Craddock N; Gill M; Korszun A; et alMaier W; Middleton L; Mors O; Owen MJ; Perry J; Preisig M; Reich T; Rice J; Rietschel M; Jones L; Sham P; Farmer AE. (15 Nov 2005). Whole genome linkage scan of recurrent depressive disorder from the depression network study. HUMAN MOLECULAR GENETICS. 14:3337-3345. Author weblink DOI.
  • Yu Y; Wyszynski DF; Waterworth DM; Wilton SD; Barter PJ; Kesaniemi YA; Mahley RW; McPherson R; et alWaeber G; Bersot TP; Ma QL; Sharma SS; Montgomery DS; Middleton LT; Sundseth SS; Mooser V; Grundy SM; Farrer LA. (1 Oct 2005). Multiple QTLs influencing triglyceride and HDL and total cholesterol levels identified in families with atherogenic dyslipidemia. JOURNAL OF LIPID RESEARCH. 46:2202-2213. Author weblink DOI.
  • Yu Y; Wyszynski DF; Waterworth DM; Wilton SD; Barter PJ; Kesäniemi YA; Mahley RW; McPherson R; et alWaeber G; Bersot TP; Ma Q; Sharma SS; Montgomery DS; Middleton LT; Sundseth SS; Mooser V; Grundy SM; Farrer LA. (Oct 2005). Multiple QTLs influencing triglyceride and HDL and total cholesterol levels identified in families with atherogenic dyslipidemia. J Lipid Res. 46:2202-2213. DOI.
  • McCarthy AD; Kennedy JL; Middleton LT. (29 Aug 2005). Pharmacogenetics in drug development. Philos Trans R Soc Lond B Biol Sci. 360:1579-1588. DOI.
  • Roses AD; Burns DK; Chissoe S; Middleton L; St Jean P. (1 Feb 2005). Disease-specific target selection: a critical first step down the right road. Drug Discov Today. 10:177-189. DOI.
  • Wyszynski DF; Waterworth DM; Barter PJ; Cohen J; Kesaniemi YA; Mahley RW; McPherson R; Waeber G; et alBersot TP; Sharma SS; Nolan V; Middleton LT; Sundseth SS; Farrer LA; Mooser V; Grundy SM. (15 Jan 2005). Relation between atherogenic dyslipidemia and the adult treatment programm-ill definition of metabolic syndrome (genetic epidemiology of metabolic syndrome project). AMERICAN JOURNAL OF CARDIOLOGY. 95:194-198. Author weblink DOI.
  • Hauser ER; Crossman DC; Granger CB; Haines JL; Jones CJ; Mooser V; McAdam B; Winkelmann BR; et alWiseman AH; Muhlestein JB; Bartel AG; Dennis CA; Dowdy E; Estabrooks S; Eggleston K; Francis S; Roche K; Clevenger PW; Huang L; Pedersen B; Shah S; Schmidt S; Haynes C; West S; Asper D; Booze M; Sharma S; Sundseth S; Middleton L; Roses AD; Hauser MA; Vance JM; Pericak-Vance MA; Kraus WE. (Sep 2004). A genomewide scan for early-onset coronary artery disease in 438 families: the GENECARD Study. Am J Hum Genet. 75:436-447. DOI.
  • Li YJ; Oliveira SA; Xu PT; Martin ER; Stenger JE; Scherzer CR; Hauser MA; Scott WK; et alSmall GW; Nance MA; Watts RL; Hubble JP; Koller WC; Pahwa R; Stern MB; Hiner BC; Jankovic J; Goetz CG; Mastaglia F; Middleton LT; Roses AD; Saunders AM; Schmechel DE; Gullans SR; Haines JL; Gilbert JR; Vance JM; Pericak-Vance MA. (15 Dec 2003). Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease. HUMAN MOLECULAR GENETICS. 12:3259-3267. Author weblink DOI.
  • Schmith VD; Campbell DA; Sehgal S; Anderson WH; Burns DK; Middleton LT; Roses AD. (Aug 2003). Pharmacogenetics and disease genetics of complex diseases. Cell Mol Life Sci. 60:1636-1646. DOI.
  • Oliveira SA; Scott WK; Nance MA; Watts RL; Hubble JP; Koller WC; Lyons KE; Pahwa R; et alStern MB; Hiner BC; Jankovic J; Ondo WG; Allen FH; Scott BL; Goetz CG; Small GW; Mastaglia FL; Stajich JM; Zhang FY; Booze MW; Reaves JA; Middleton LT; Haines JL; Pericak-Vance MA; Vance JM; Martin ER. (1 Jul 2003). Association study of Parkin gene polymorphisms with idiopathic Parkinson disease. ARCHIVES OF NEUROLOGY. 60:975-980. Author weblink DOI.
  • Mooser V; Waterworth DM; Isenhour T; Middleton L. (Jul 2003). Cardiovascular pharmacogenetics in the SNP era. J Thromb Haemost. 1:1398-1402.
  • Antonellis A; Ellsworth RE; Sambuughin N; Puls I; Abel A; Lee-Lin SQ; Jordanova A; Kremensky I; et alChristodoulou K; Middleton LT; Sivakumar K; Ionasescu V; Funalot B; Vance JM; Goldfarb LG; Fischbeck KH; Green ED. (May 2003). Glycyl tRNA synthetase mutations in Charcot-Marie-Tooth disease type 2D and distal spinal muscular atrophy type V. Am J Hum Genet. 72:1293-1299. DOI.
  • Oliveira SA; Scott WK; Martin ER; Nance MA; Watts RL; Hubble JP; Koller WC; Pahwa R; et alStern MB; Hiner BC; Ondo WG; Allen FH; Scott BL; Goetz CG; Small GW; Mastaglia F; Stajich JM; Zhang F; Booze MW; Winn MP; Middleton LT; Haines JL; Pericak-Vance MA; Vance JM. (May 2003). Parkin mutations and susceptibility alleles in late-onset Parkinson's disease. Ann Neurol. 53:624-629. DOI.
  • van der Walt JM; Martin ER; Scott WK; Zhang F; Nance MA; Watts RL; Hubble JP; Haines JL; et alKoller WC; Lyons K; Pahwa R; Stern MB; Colcher A; Hiner BC; Jankovic J; Ondo WG; Allen FH; Goetz CG; Small GW; Mastaglia F; Roses AD; Stajich JM; Booze MW; Fujiwara K; Gibson RA; Middleton LT; Scott BL; Pericak-Vance MA; Vance JM. (8 Apr 2003). Genetic polymorphisms of the N-acetyltransferase genes and risk of Parkinson's disease. Neurology. 60:1189-1191.
  • van der Walt JM; Nicodemus KK; Martin ER; Scott WK; Nance MA; Watts RL; Hubble JP; Haines JL; et alKoller WC; Lyons K; Pahwa R; Stern MB; Colcher A; Hiner BC; Jankovic J; Ondo WG; Allen FH; Goetz CG; Small GW; Mastaglia F; Stajich JM; McLaurin AC; Middleton LT; Scott BL; Schmechel DE; Pericak-Vance MA; Vance JM. (Apr 2003). Mitochondrial polymorphisms significantly reduce the risk of Parkinson disease. Am J Hum Genet. 72:804-811.
  • Zamba-Papanicolaou E; Christodoulou K; Christodoulou C; Kyriakidesl T; Middleton LT. (Dec 2002). Hereditary motor neuronopathies. Rev Neurol (Paris). 158:1220-1224.
  • Georgiou DM; Zidar J; Korosec M; Middleton LT; Kyriakides T; Christodoulou K. (Oct 2002). A novel NF-L mutation Pro22Ser is associated with CMT2 in a large Slovenian family. Neurogenetics. 4:93-96.
  • Li YJ; Scott WK; Hedges DJ; Zhang F; Gaskell PC; Nance MA; Watts RL; Hubble JP; et alKoller WC; Pahwa R; Stern MB; Hiner BC; Jankovic J; Allen FA; Goetz CG; Mastaglia F; Stajich JM; Gibson RA; Middleton LT; Saunders AM; Scott BL; Small GW; Nicodemus KK; Reed AD; Schmechel DE; Welsh-Bohmer KA; Conneally PM; Roses AD; Gilbert JR; Vance JM; Haines JL; Pericak-Vance MA. (Apr 2002). Age at onset in two common neurodegenerative diseases is genetically controlled. Am J Hum Genet. 70:985-993.
  • Martin ER; Scott WK; Nance MA; Watts RL; Hubble JP; Koller WC; Lyons K; Pahwa R; et alStern MB; Colcher A; Hiner BC; Jankovic J; Ondo WG; Allen FH; Goetz CG; Small GW; Masterman D; Mastaglia F; Laing NG; Stajich JM; Ribble RC; Booze MW; Rogala A; Hauser MA; Zhang F; Gibson RA; Middleton LT; Roses AD; Haines JL; Scott BL; Pericak-Vance MA; Vance JM. (14 Nov 2001). Association of single-nucleotide polymorphisms of the tau gene with late-onset Parkinson disease. JAMA. 286:2245-2250.
  • Scott WK; Nance MA; Watts RL; Hubble JP; Koller WC; Lyons K; Pahwa R; Stern MB; et alColcher A; Hiner BC; Jankovic J; Ondo WG; Allen FH; Goetz CG; Small GW; Masterman D; Mastaglia F; Laing NG; Stajich JM; Slotterbeck B; Booze MW; Ribble RC; Rampersaud E; West SG; Gibson RA; Middleton LT; Roses AD; Haines JL; Scott BL; Vance JM; Pericak-Vance MA. (14 Nov 2001). Complete genomic screen in parkinson disease - Evidence for multiple genes. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION. 286:2239-2244. Author weblink DOI.
  • Oliveira SA; Martin ER; Scott WK; Nance MA; Watts RL; Hubble JP; Koller WC; Pahwa R; et alStern MB; Hiner BC; Jankovic J; Goetz CG; Small GW; Hauser MA; Middleton LT; Roses AD; Haines JL; Scott BL; Pericak-Vance MA; Vance JM. (1 Oct 2001). Association of tau with late-onset Parkinson disease. AMERICAN JOURNAL OF HUMAN GENETICS. 69:511-511. Author weblink.
  • Scott WK; Stajich JM; Scott BL; Nance MA; Watts RL; Hubble JP; Haines JL; Koller WC; et alPahwa R; Stern MB; Hiner BC; Jankovic J; Allen FH; Goetz CG; Small GW; Mastaglia F; Middleton LT; Roses AD; Vance JM; Pericak-Vance MA. (1 Oct 2001). Complete genomic screen in idiopathic Parkinson disease. AMERICAN JOURNAL OF HUMAN GENETICS. 69:513-513. Author weblink.
  • Christodoulou K; Deymeer F; Serdaroğlu P; Ozdemir C; Poda M; Georgiou DM; Ioannou P; Tsingis M; et alZamba E; Middleton LT. (Jul 2001). Mapping of the second Friedreich's ataxia (FRDA2) locus to chromosome 9p23-p11: evidence for further locus heterogeneity. Neurogenetics. 3:127-132.
  • Christodoulou K; Zamba E; Tsingis M; Mubaidin A; Horani K; Abu-Sheik S; El-Khateeb M; Kyriacou K; et alKyriakides T; Al-Qudah AK; Middleton L. (Dec 2000). A novel form of distal hereditary motor neuronopathy maps to chromosome 9p21.1-p12. Ann Neurol. 48:877-884.
  • Neocleous V; Humphray SJ; Howard PJ; Hammond S; Tsingis M; Georgiou A; Al-Qudah AK; Mubaidin A; et alHorani K; Askanas V; Engel K; Dalakas M; Rowland LP; Mirabella M; Zamba E; Kyriakides T; Middleton LT; Christodoulou K. (1 Oct 2000). BAC based physical map of the distal hereditary motor neuronopathy (HMN-J) and autosomal recessive inclusion body myopathy (AR-IBM) region on chromosome 9p21.1-p12. AMERICAN JOURNAL OF HUMAN GENETICS. 67:407-407. Author weblink.
  • Hauser ER; Mooser V; Schmidt S; Crossman DC; Haines JL; Jones C; Winkelmann B; Foster C; et alHaynes C; Dowdy ZE; Estabrooks SE; Middleton LT; Manasco P; Roses AD; Granger CB; Kraus WE; Pericak-Vance MA. (1 Oct 2000). Concordance for cardiovascular risk factors in affected sib pairs (ASPs) with early-onset coronary artery disease (CAD). AMERICAN JOURNAL OF HUMAN GENETICS. 67:212-212. Author weblink.
  • Wang HL; Ohno K; Milone M; Brengman JM; Evoli A; Batocchi AP; Middleton LT; Christodoulou K; et alEngel AG; Sine SM. (1 Sep 2000). Fundamental gating mechanism of nicotinic receptor channel revealed by mutation causing a congenital myasthenic syndrome. JOURNAL OF GENERAL PHYSIOLOGY. 116:449-460. Author weblink DOI.
  • Middleton L; Ohno K; Christodoulou K; Brengman J; Milone M; Neocleous V; Serdaroğlu P; Deymeer F; et alOzdemir C; Mubaidin A; Horany K; Al-Shehab A; Mavromatis I; Mylonas I; Tsingis M; Zamba E; Pantzaris M; Kyriallis K; Engel AG. (22 Sep 1999). Chromosome 17p-linked myasthenias stem from defects in the acetylcholine receptor epsilon-subunit gene. Neurology. 53:1076-1082.
  • Middleton LT; Christodoulou K; Mubaidin A; Zamba E; Tsingis M; Kyriacou K; Abu-Sheikh S; Kyriakides T; et alNeocleous V; Georgiou DM; el-Khateeb M; al-Qudah A; Horany K. (14 Sep 1999). Distal hereditary motor neuronopathy of the Jerash type. Ann N Y Acad Sci. 883:439-442.
  • Middleton LT; Christodoulou K; Mubaidin A; Zamba E; Tsingis M; Kyriacou K; Abu-Sheikh S; Kyriakides T; et alNeocleous V; Georgiou DM; el-Khateeb M; al-Qudah A; Horany K. (14 Sep 1999). Distal hereditary motor neuronopathy of the Jerash type. Ann N Y Acad Sci. 883:65-68.
  • Pattichis CS; Schofield I; Merletti R; Parker PA; Middleton LT. (Jul 1999). Introduction to this special issue. Intelligent data analysis in electromyography and electroneurography. Med Eng Phys. 21:379-388.
  • Kyriacou K; Mikellidou C; Hadjianastasiou A; Middleton L; Panousopoulos A; Kyriakides T. (May 1999). Ultrastructural diagnosis of mitochondrial encephalomyopathies revisited. Ultrastruct Pathol. 23:163-170.
  • Middleton LT; Christodoulou K; Deymeer F; Serdaroglu P; Ozdemir C; al-Qudah AK; al-Shehab A; Mavromatis I; et alMylonas I; Evoli A; Tsingis M; Zamba E; Kyriallis K. (13 May 1998). Congenital myasthenic syndrome. (CMS) type Ia. Clinical and genetic diversity. Ann N Y Acad Sci. 841:157-166.
  • Kalaydjieva L; Nikolova A; Turnev I; Petrova J; Hristova A; Ishpekova B; Petkova I; Shmarov A; et alStancheva S; Middleton L; Merlini L; Trogu A; Muddle JR; King RHM; Thomas PK. (1 Mar 1998). Hereditary motor and sensory neuropathy - Lom, a novel demyelinating neuropathy associated with deafness in gypsies - Clinical, electrophysiological and nerve biopsy findings. BRAIN. 121:399-408. Author weblink DOI.
  • Drousiotou A; Ioannou P; Georgiou T; Mavrikiou E; Christopoulos G; Kyriakides T; Voyasianos M; Argyriou A; et alMiddleton L. (1998). Neonatal screening for Duchenne muscular dystrophy: a novel semiquantitative application of the bioluminescence test for creatine kinase in a pilot national program in Cyprus. Genet Test. 2:55-60.
  • Lennon F; Pericak-Vance MA; Speer MC; West SG; Menold MM; Stajich JM; Wolpert CM; Slotterbeck BD; et alSaito M; Tim RW; Rozear MP; Middleton LT; Tsuji S; Vance JM. (1 Oct 1997). CMT2 mapping progress: Confirmation of a second locus and evidence for additional genetic heterogeneity. AMERICAN JOURNAL OF HUMAN GENETICS. 61:A282-A282. Author weblink.
  • Christodoulou K; Deymeer F; Serdaroglu P; Ozdemir C; Georgiou DM; Papadopoulou E; Zamba E; Middleton LT. (1 Oct 1997). Genetic heterogeneity in Friedreich's ataxia: indication for a second locus on chromosome 9. AMERICAN JOURNAL OF HUMAN GENETICS. 61:A271-A271. Author weblink.
  • Neocleous V; Middleton LT; Christodoulou K. (1 Oct 1997). Mutation screening in the synaptobrevin-2 gene in patients with familial infantile myasthenia. AMERICAN JOURNAL OF HUMAN GENETICS. 61:A341-A341. Author weblink.
  • Tao YY; Blomeier H; Richards C; Stajich JM; Gaskell P; Slotterbeck B; Tsuji S; Middleton L; et alPericak-Vance MA; Ben-Othmane K; Vance JM. (1 Oct 1997). Refinement of the Charcot-Marie-Tooth type 2 (CMT2A) region on chromosome 1p36.2 and formation of a YAC/PAC contig. AMERICAN JOURNAL OF HUMAN GENETICS. 61:A245-A245. Author weblink.
  • Pericak-Vance MA; Speer MC; Lennon F; West SG; Menold MM; Stajich JM; Wolpert CM; Slotterbeck BD; et alSaito M; Tim RW; Rozear MP; Middleton LT; Tsuji S; Vance JM. (Sep 1997). Confirmation of a second locus for CMT2 and evidence for additional genetic heterogeneity. Neurogenetics. 1:89-93.
  • Kyriacou K; Kassianides B; Hadjisavvas A; Middleton L; Kyriakides T. (May 1997). The role of electron microscopy in the diagnosis of nonneoplastic muscle diseases. Ultrastruct Pathol. 21:243-252.
  • Christodoulou K; Tsingis M; Deymeer F; Serdaroglu P; Ozdemir C; Al-Shehab A; Bairactaris C; Mavromatis I; et alMylonas I; Evoli A; Kyriallis K; Middleton LT. (Apr 1997). Mapping of the familial infantile myasthenia (congenital myasthenic syndrome type Ia) gene to chromosome 17p with evidence of genetic homogeneity. Hum Mol Genet. 6:635-640.
  • Dean G; Aksoy H; Akalin T; Middleton L; Kyriallis K. (12 Feb 1997). Multiple sclerosis in the Turkish- and Greek-speaking communities of Cyprus. A United Nations (UNHCR) Bicommunal Project. J Neurol Sci. 145:163-168.
  • Patsalis PC; Sismani C; Hadjimarcou MI; Rose N; Stylianidou G; Koukoulli R; Anastasiadou V; Deltas CC; et alMiddleton L. (1997). Cytogenetic and fragile X molecular testing of individuals with mental retardation of unknown etiology. Genet Couns. 8:1-6.
  • Angastiniotis M; Middleton L. (1997). Genetic services in Cyprus. Eur J Hum Genet. 5 Suppl 2:51-57.
  • Kalaydjieva L; Hallmayer J; Chandler D; Savov A; Nikolova A; Angelicheva D; King RH; Ishpekova B; et alHoneyman K; Calafell F; Shmarov A; Petrova J; Turnev I; Hristova A; Moskov M; Stancheva S; Petkova I; Bittles AH; Georgieva V; Middleton L; Thomas PK. (Oct 1996). Gene mapping in Gypsies identifies a novel demyelinating neuropathy on chromosome 8q24. Nat Genet. 14:214-217. DOI.
  • Middleton LT. (Mar 1996). Congenital myasthenic syndromes. 34th ENMC International Workshop, 10-11 June 1995. Neuromuscul Disord. 6:133-136.
  • Noguchi S; McNally EM; Ben Othmane K; Hagiwara Y; Mizuno Y; Yoshida M; Yamamoto H; Bönnemann CG; et alGussoni E; Denton PH; Kyriakides T; Middleton L; Hentati F; Ben Hamida M; Nonaka I; Vance JM; Kunkel LM; Ozawa E. (3 Nov 1995). Mutations in the dystrophin-associated protein gamma-sarcoglycan in chromosome 13 muscular dystrophy. Science. 270:819-822.
  • CHRISTODOULOU K; KYRIAKIDES T; HRISTOVA AH; GEORGIOU DM; KALAJDJIEVA L; YSHPEKOVA B; IVANOVA T; WEBER JL; et alMIDDLETON LT. (1 Oct 1995). MAPPING OF AN AUTOSOMAL-DOMINANT DISTAL FORM OF SPINAL MUSCULAR-ATROPHY TO CHROMOSOME 7P. AMERICAN JOURNAL OF HUMAN GENETICS. 57:1082-1082. Author weblink.
  • BENOTHMANE K; SPEER MC; STAUFFER J; BLEL S; MIDDLETON L; BENHAMIDA C; ETRIBI A; LOEB D; et alHENTATI F; ROSES AD; BENHAMIDA M; PERICAKVANCE MA; VANCE JM. (1 Sep 1995). EVIDENCE FOR LINKAGE DISEQUILIBRIUM IN CHROMOSOME 13-LINKED DUCHENNE-LIKE MUSCULAR-DYSTROPHY (LGMD2C). AMERICAN JOURNAL OF HUMAN GENETICS. 57:732-734. Author weblink.
  • Christodoulou K; Kyriakides T; Hristova AH; Georgiou DM; Kalaydjieva L; Yshpekova B; Ivanova T; Weber JL; et alMiddleton LT. (Sep 1995). Mapping of a distal form of spinal muscular atrophy with upper limb predominance to chromosome 7p. Hum Mol Genet. 4:1629-1632.
  • Pattichis CS; Charalambous C; Middleton LT. (May 1995). Efficient training of neural network models in classification of electromyographic data. Med Biol Eng Comput. 33:499-503.
  • PATTICHIS CS; CHARALAMBOUS C; MIDDLETON LT. (1 May 1995). EFFICIENT TRAINING OF NEURAL-NETWORK MODELS IN CLASSIFICATION OF ELECTROMYOGRAPHIC DATA. MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING. 33:499-503. Author weblink DOI.
  • PATTICHIS CS; SCHIZAS CN; MIDDLETON LT. (1 May 1995). NEURAL-NETWORK MODELS IN EMG DIAGNOSIS. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING. 42:486-496. Author weblink DOI.
  • NICOLAIDES AN; BARNETT HJM; BELCARO GV; BERNSTEIN EF; CALLOW A; EASTCOTT HHG; EIKELBOOM B; EKLOF B; et alGEROULAKOS G; HALLIDAY A; HOBSON R; KALODIKI E; LUSBY R; MALIKIDES A; MIDDLETON LT; MOORE WS; NORRIS J; PRESCOTT L; RAMASWAMI G; RUTHERFORD R; SANDMANN W; SHANIK G; SPARTERA C; THOMAS D. (1 Mar 1995). CONSENSUS STATEMENT ON THE MANAGEMENT OF PATIENTS WITH ASYMPTOMATIC ATHEROSCLEROTIC CAROTID BIFURCATION LESIONS. INTERNATIONAL ANGIOLOGY. 14:5-17. Author weblink.
  • CARIOLOU MA; KOKKOFITOU A; MANOLI P; CHRISTOU S; KARAGRIGORIOU A; MIDDLETON L. (1 Jan 1995). UNDEREXPRESSION OF THE APOLIPOPROTEIN E2 AND E4 ALLELES IN THE GREEK CYPRIOT POPULATION OF CYPRUS. GENETIC EPIDEMIOLOGY. 12:489-497. Author weblink DOI.
  • Cariolou MA; Kokkofitou A; Manoli P; Christou S; Karagrigoriou A; Middleton L. (1995). Underexpression of the apolipoprotein E2 and E4 alleles in the Greek Cypriot population of Cyprus. Genet Epidemiol. 12:489-497. DOI.
  • Kyriakides T; Gabriel G; Drousiotou A; Meznanic-Petrusa M; Middleton L. (Jul 1994). Dystrophinopathy presenting as congenital muscular dystrophy. Neuromuscul Disord. 4:387-392.
  • Middleton LT; Moser H. (May 1994). 23rd ENMC Workshop on Rare Neuromuscular Diseases. 4-6 June, Baarn, The Netherlands. Neuromuscul Disord. 4:273-275.
  • Boteva K; Papageorgiou E; Georgiou C; Angastiniotis M; Middleton LT; Constantinou-Deltas CD. (May 1994). Novel cystic fibrosis mutation associated with mild disease in Cypriot patients. Hum Genet. 93:529-532.
  • Christodoulou K; Ioannou P; Middleton L. (1994). Molecular genetic detection of Xp21 muscular dystrophy carriers in Cyprus. Biomed Pharmacother. 48:355-358.
  • Ben Hamida M; Belal S; Sirugo G; Ben Hamida C; Panayides K; Ionannou P; Beckmann J; Mandel JL; et alHentati F; Koenig M. (Nov 1993). Friedreich's ataxia phenotype not linked to chromosome 9 and associated with selective autosomal recessive vitamin E deficiency in two inbred Tunisian families. Neurology. 43:2179-2183.
  • VANCE JM; BENOTHMANE K; DENG H; MIDDLETON LT; LOPREST L; WILKINSON KM; LENNON F; ROZEAR MM; et alSTAJICH JM; GASKELL PC; ROSES AD; SIDDIQUE T; PERICAKVANCE MA. (1 Sep 1993). MAPPING OF THE AUTOSOMAL-DOMINANT CMT2 (CMT2A) LOCUS IN THE REGION OF CHROMOSOME-1P35-36. AMERICAN JOURNAL OF HUMAN GENETICS. 53:1096-1096. Author weblink.
  • Ben Othmane K; Middleton LT; Loprest LJ; Wilkinson KM; Lennon F; Rozear MP; Stajich JM; Gaskell PC; et alRoses AD; Pericak-Vance MA. (Aug 1993). Localization of a gene (CMT2A) for autosomal dominant Charcot-Marie-Tooth disease type 2 to chromosome 1p and evidence of genetic heterogeneity. Genomics. 17:370-375.
  • Middleton LT; Anastasiades V; Panayidou K; Georghiou D; Kalli E; Gabriel G; Myrianthopoulos NC. (1 Dec 1992). New hereditary malformation syndrome of unusual facial appearance, skeletal deformities, and musculoskeletal and sensory defects. Am J Med Genet. 44:757-761. DOI.
  • BELAL S; PANAYIDES K; SIRUGO G; BENHAMIDA C; IOANNOU P; HENTATI F; BECKMANN J; KOENIG M; et alMANDEL JL; BENHAMIDA M; MIDDLETON LT. (1 Dec 1992). STUDY OF LARGE INBRED FRIEDREICH ATAXIA FAMILIES REVEALS A RECOMBINATION BETWEEN D9S15 AND THE DISEASE LOCUS. AMERICAN JOURNAL OF HUMAN GENETICS. 51:1372-1376. Author weblink.
  • Alberts MJ; Ioannou P; Deucher R; Gilbert J; Lee J; Middleton L; Roses AD. (Oct 1992). Isolation of a cytochrome oxidase gene overexpressed in Alzheimer's disease brain. Mol Cell Neurosci. 3:461-470.
  • ALBERTS MJ; IOANNOU P; DEUCHER R; GILBERT J; LEE J; MIDDLETON L; ROSES AD. (1 Oct 1992). ISOLATION OF A CYTOCHROME-OXIDASE GENE OVEREXPRESSED IN ALZHEIMERS-DISEASE BRAIN. MOLECULAR AND CELLULAR NEUROSCIENCE. 3:461-470. Author weblink.
  • Ioannou P; Christopoulos G; Panayides K; Kleanthous M; Middleton L. (Sep 1992). Detection of Duchenne and Becker muscular dystrophy carriers by quantitative multiplex polymerase chain reaction analysis. Neurology. 42:1783-1790.
  • IOANNOU P; PANAYIDOU K; CHRISTOPOULOS G; MIDDLETON L. (1 Oct 1991). CARRIER DETECTION IN DUCHENNE AND BECKER MUSCULAR-DYSTROPHY BY QUANTITATIVE MULTIPLEX PCR. AMERICAN JOURNAL OF HUMAN GENETICS. 49:191-191. Author weblink.
  • Middleton LT; Dean G. (May 1991). Multiple sclerosis in Cyprus. J Neurol Sci. 103:29-36.
  • MIDDLETON LT; DEAN G. (1 May 1991). MULTIPLE-SCLEROSIS IN CYPRUS. JOURNAL OF THE NEUROLOGICAL SCIENCES. 103:29-36. Author weblink DOI.
  • MIDDLETON LT; PATTICHIS CS; SCHIZAS CN; LAZAROU K; CHRISTOPHIDOU M. (1 Oct 1990). ARTIFICIAL NEURAL NETWORKS IN CLINICAL ELECTROMYOGRAPHY - ELECTRODIAGNOSTIC ASPECTS. MUSCLE & NERVE. 13:981-981. Author weblink.
  • PATTICHIS CS; SCHIZAS CN; LAZAROU K; MIDDLETON LT; FINCHAM WF. (1 Oct 1990). ARTIFICIAL NEURAL NETWORKS IN CLINICAL ELECTROMYOGRAPHY - TECHNICAL ASPECTS. MUSCLE & NERVE. 13:977-977. Author weblink.
  • SCHIZAS CN; PATTICHIS CS; SCHOFIELD IS; FAWCETT PR; MIDDLETON LT. (1 Sep 1990). ARTIFICIAL NEURAL NETS IN COMPUTER-AIDED MACRO MOTOR UNIT POTENTIAL CLASSIFICATION. IEEE ENGINEERING IN MEDICINE AND BIOLOGY MAGAZINE. 9:31-38. Author weblink DOI.
  • Waddy HM; Misra VP; King RH; Thomas PK; Middleton L; Ormerod IE. (Oct 1989). Focal cranial nerve involvement in chronic inflammatory demyelinating polyneuropathy: clinical and MRI evidence of peripheral and central lesions. J Neurol. 236:400-405.
  • PATTICHIS CS; SCHIZAS CN; MIDDLETON LT; FINCHAM WF. (1 Sep 1989). ARTIFICIAL NEURAL NET ALGORITHMS IN MOTOR UNIT POTENTIAL CLASSIFICATION. MUSCLE & NERVE. 12:753-753. Author weblink.
  • MALIKIDES A; MIDDLETON L; PETRONDAS D; PATTICHIS C. (1 Sep 1989). CENTRAL MOTOR CONDUCTIONS AND PERIPHERAL PROXIMAL MOTOR CONDUCTIONS IN THE UPPER LIMB. MUSCLE & NERVE. 12:770-770. Author weblink.
  • HOLT IJ; HARDING AE; MIDDLETON L; CHRYSOSTOMOU G; SAID G; KING RHM; THOMAS PK. (11 Mar 1989). MOLECULAR-GENETICS OF AMYLOID NEUROPATHY IN EUROPE. LANCET. 1:524-526. Author weblink.
  • DEAN G; CHAMBERLAIN S; MIDDLETON L. (12 Mar 1988). FRIEDREICHS ATAXIA IN KATHIKAS-ARODHES, CYPRUS. LANCET. 1:587-587. Author weblink.
  • MIDDLETON LT; PETRONDAS D. (1 Aug 1987). ELECTROPHYSIOLOGICAL STUDIES IN THE DIAGNOSIS OF THORACIC OUTLET SYNDROME. ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY. 67:P33-P33. Author weblink.
  • Middleton L. (1987). Training respite workers for Alzheimer's families. Aging. 24-26.
  • Middleton L. (Mar 1986). An overview of dementia. J Enterostomal Ther. 13:54-61.
  • MIDDLETON L; TSOLAKIS S; KATSOUNOTOU P. (1 Jan 1983). PROXIMAL NERVE LATENCY MEASUREMENTS IN THE UPPER EXTREMITIES. ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY. 56:S135-S135. Author weblink.
  • Capesius P; Babin E; Soutter JW; Middleton L; Maitrot D; Wackenheim A. (1978). Compression of the dural sac by anomalous lumbar articular processes as demonstrated by radiculosaccography. J Belge Radiol. 61:173-179.

Conferences

  • Votsi C; Nicolaou P; Georghiou A; Kleopa K; Middleton LT; Pantzaris M; Papacostas S; Kyriakides T; et alChristodoulou K; Zamba-Papanicolaou E. Investigation of sporadic ataxia patients in the Cypriot population. 14th Congress of European-Federation-of-Neurological-Societies, Sep 2010. 17:605-605. WILEY-BLACKWELL (1 Sep 2010). Author weblink.
  • Gallo V; Vineis P; Riboli E; Middleton L. The large- scale European prospective investigation into cancer and nutrition (EPIC) unravels risk factors for ALS. 13th Congress of the European-Federation-of-Neurological-Societies, 12 Sep 2009 - 15 Sep 2009. 16:218-218. WILEY-BLACKWELL PUBLISHING, INC (1 Oct 2009). Author weblink.
  • Domenici E; Prokopenko I; Wille D; Tozzi F; McCarthy A; Weber B; Middleton L; Muglia P. Identification of diagnostic biomarkers for depression by multi analyte profiling of peripheral samples from case/control collections. 14th World Congress on Psychiatric Genetics, 28 Oct 2006 - 1 Nov 2006. 141B:790-790. WILEY-LISS (5 Oct 2006). Author weblink.
  • Prokopenko I; Tozzi F; Vicentini E; Vanzo A; Brewster S; Perry J; Chissoe S; Jean PS; et alBansal A; Upmanyu R; Budde L; Allan C; Riley J; Domenici E; Merlo-Pich E; McCarthy A; Iolsboer F; Roses A; Middleton L; Berrettini W; Kennedy J; Muglia P. Major depressive disorder: Genetic association analyses using subphenotypes. 14th World Congress on Psychiatric Genetics, 28 Oct 2006 - 1 Nov 2006. 141B:809-809. WILEY-LISS (5 Oct 2006). Author weblink.
  • Prokopenko I; Tozzi F; Perry JD; McCarthy AD; Chissoe SL; St Jean PL; Alalouff S; Brewster SR; et alKennedy JL; Middleton LT; Holsboer F; Muglia P. Major depressive disorder: Identifying phenotypic subtypes for genetic studies. 13th World Congress on Psychiatric Genetics, 4 Sep 2005 - 8 Sep 2005. 138B:107-107. WILEY-LISS (5 Sep 2005). Author weblink.
  • Pillai SG; St Jean PL; Yarnall DP; Wagner MJ; Sundseth SS; DeMent RM; Riley JH; Seghal SX; et alFleming TK; Hill SN; Bennett GC; Brewster SR; Meldrum EC; Purvis IJ; Middleton LT; Burns DK; Spurr NK; Roses AD; Hosford DA; Chissoe SL. A high throughput genetic association study of tractable genes in asthma. Annual Meeting of the American-Society-of-Human-Genetics, 4 Nov 2003 - 8 Nov 2003. 73:525-525. UNIV CHICAGO PRESS (1 Nov 2003). Author weblink.
  • Oliveira SA; Martin ER; Scott WK; Zhang F; Stajich JM; Middleton LT; Roses AD; Scott BL; et alFujiwara K; Pericak-Vance MA; Vance JM. Defining the linkage disequilibrium region containing the Tau gene and identifying haplotype tagging polymorphisms. Annual Meeting of the American-Society-of-Human-Genetics, 4 Nov 2003 - 8 Nov 2003. 73:532-532. UNIV CHICAGO PRESS (1 Nov 2003). Author weblink.
  • Middleton L. Genetics of complex disorders and drug discovery. British Human Genetics Conference, 15 Sep 2003 - 17 Sep 2003. 40:S13-S13. B M J PUBLISHING GROUP (1 Sep 2003). Author weblink.
  • Zamba-Papanicolaou E; Christoloudou K; Christoloudou C; Kyriakides T; Middleton LT. Hereditary motor Neuronopathies. 6th Meeting on Diseases of the Peripheral Nervous System, 25 Jan 2002 - 26 Jan 2002. 158:1220-1224. MASSON EDITEUR (1 Dec 2002). Author weblink.
  • Hauser ER; Crossman DC; Granger C; Haines JL; Jones CJH; Mooser V; Hauser MA; Middleton L; et alRoses AD; Pericak-Vance MA; Vance JM; Kraus WE. Results of a genome-wide scan in 438 families with early-onset coronary artery disease. American-Heart-Association Abstracts From Scientific Sessions, 17 Nov 2002 - 20 Nov 2002. 106:745-745. LIPPINCOTT WILLIAMS & WILKINS (5 Nov 2002). Author weblink.
  • Hauser ER; Crossman DC; Granger C; Haines JL; Jones CJH; Mooser V; Middleton L; Roses AD; et alHauser MA; Pericak-Vance M; Vance JM; Kraus WE. A genome-wide scan in 433 families with early-onset coronary artery disease. 52nd Annual Meeting of the American-Society-of-Human-Genetics, 15 Oct 2002 - 19 Oct 2002. 71:459-459. UNIV CHICAGO PRESS (1 Oct 2002). Author weblink.
  • PATTICHIS CS; ELIA A; SCHIZAS CN; MIDDLETON LT. CLASSIFICATION PERFORMANCE OF MOTOR UNIT ACTION POTENTIAL FEATURES. 16th Annual International Conference of the IEEE Engineering-in-Medicine-and-Biology-Society on Engineering Advances: New Opportunities for Biomedical Engineers, 3 Nov 1994 - 6 Nov 1994. 1338-1339. I E E E (1 Jan 1994). Author weblink DOI.
Share this on Delicious
Tweet this
Digg this
Stumble this
Share this on Facebook