Dr Lan Zhao

Publications


Journals

  • Fang W; Zhao L; Xiong C; He J; Wilkins MR. (23 Nov 2010). Right Ventricle (18)FDG Uptake in Pulmonary Hypertension: A New Biomarker. CIRCULATION. 122. Author weblink.
  • Wojciak-Stothard B; Zhao L; Oliver E; Dubois O; Wu Y; Kardassis D; Vasilaki E; Huang M; et alMitchell JA; Louise H; Prendergas GC; Wilkins MR. (26 Apr 2012). Role of RhoB in the Regulation of Pulmonary Endothelial and Smooth Muscle Cell Responses to Hypoxia. Circ Res. DOI.
  • Li Y-Y; Zhai Z-G; Yang Y-H; Pang B-S; Wang H-Y; Zhang W; Zhao L; Wang J; et alWang C. (1 Apr 2011). Association of the 894 G > T polymorphism in the endothelial nitric oxide synthase gene with risk of venous thromboembolism in Chinese population. THROMBOSIS RESEARCH. 127:324-327. DOI.
  • Robbins IM; Hemnes AR; Gibbs JS; Christman BW; Howard L; Meehan S; Cabrita I; Gonzalez R; et alOyler T; Zhao L; Du R-H; Mendes LA; Wilkins MR. (1 Feb 2011). Safety of sapropterin dihydrochloride (6r-bh4) in patients with pulmonary hypertension. EXPERIMENTAL LUNG RESEARCH. 37:26-34. DOI.
  • Zhao L. (1 Jan 2010). Molecular Imaging of Pulmonary Hypertensive Lung. CARDIOLOGY. 117:12-12.
  • Zhai Z; Wang J; Zhao L; Yuan JX-J; Wang C. (1 Jun 2010). Pulmonary Hypertension in China Pulmonary Vascular Disease: The Global Perspective. CHEST. 137:69S-77S. DOI.
  • Francis BN; Wilkins MR; Zhao L. (Aug 2010). Tetrahydrobiopterin and the regulation of hypoxic pulmonary vasoconstriction. Eur Respir J. 36:323-330. DOI.
  • Harrington LS; Moreno L; Reed A; Wort SJ; Desvergne B; Garland C; Zhao L; Mitchell JA. (2010). The PPARbeta/delta agonist GW0742 relaxes pulmonary vessels and limits right heart hypertrophy in rats with hypoxia-induced pulmonary hypertension. PLoS One. 5:e9526. DOI.
  • WANG C; ZHAI Z; SHEN YH; ZHAO L. Clinical and genetic risk factors for venous thromboembolism in Chinese population. Front. Med. China. 2010, 1:29-35.
  • Zhao L; Sebkhi A; Ali O; Wojciak-Stothard B; Mamanova L; Yang Q; Wharton J; Wilkins MR. (1 Oct 2009). Simvastatin and sildenafil combine to attenuate pulmonary hypertension. EUROPEAN RESPIRATORY JOURNAL. 34:948-957. Author weblink DOI.
  • Wilkins MR; Zhao L. (11 Aug 2009). [Future treatment of pulmonary arterial hypertension]. Zhonghua Yi Xue Za Zhi. 89:2097-2098.
  • Zhao L. (1 Jan 2009). Simvastatin and Sildenafil Combine to Attenuate Pulmonary Hypertension. CARDIOLOGY. 114:88-88. Author weblink.
  • Wojciak-Stothard B; Torondel B; Zhao L; Renne T; Leiper JM. (1 Jan 2009). Modulation of Rac1 Activity by ADMA/DDAH Regulates Pulmonary Endothelial Barrier Function. MOLECULAR BIOLOGY OF THE CELL. 20:33-42. Author weblink DOI.
  • Wang C; JF L; Zhao L; Liu J; Wan J; Wang YX; Wang J; Wang C. Inhibition of SOC/Ca2+/NFAT pathway is involved in the anti-proliferative effect of sildenafil on pulmonary artery smooth muscle cells. Respiratory Research. 10:123.
  • Baliga RS; Zhao L; Madhani M; Lopez-Torondel B; Visintin C; Selwood D; Wilkins MR; MacAllister RJ; et alHobbs AJ. (15 Oct 2008). Synergy between natriuretic peptides and phosphodiesterase 5 inhibitors ameliorates pulmonary arterial hypertension. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 178:861-869. Author weblink DOI.
  • Wang C; Wang J; Zhao L; Wang Y; Liu J; Shi L; Xu M; Wang C. (1 Sep 2008). Sildenafil inhibits human pulmonary artery smooth muscle cell proliferation by decreasing capacitative Ca2+ entry. JOURNAL OF PHARMACOLOGICAL SCIENCES. 108:71-78. Author weblink DOI.
  • Khoo JP; Zhao L; Alp NJ; Bendall JK; Nicoli T; Rockett K; Wilkins MR; Channon KM. (26 Apr 2005). Pivotal role for endothelial tetrahydrobiopterin in pulmonary hypertension. CIRCULATION. 111:2126-2133. Author weblink DOI.
  • Zhao L; Mason NA; Strange JW; Walker H; Wilkins MR. (21 Jan 2003). Beneficial effects of phosphodiesterase 5 inhibition in pulmonary hypertension are influenced by natriuretic peptide activity. CIRCULATION. 107:234-237. Author weblink DOI.
  • Zhao L; Mason NA; Morrell NW; Kojonazarov B; Sadykov A; Maripov A; Mirrakhimov MM; Aldashev A; et alWilkins MR. (24 Jul 2001). Sildenafil inhibits hypoxia-induced pulmonary hypertension. CIRCULATION. 104:424-428. Author weblink DOI.
  • Zhao L; Sebkhi A; Nunez DJ; Long L; Haley CS; Szpirer J; Szpirer C; Williams AJ; et alWilkins MR. (23 Jan 2001). Right ventricular hypertrophy secondary to pulmonary hypertension is linked to rat chromosome 17: evaluation of cardiac ryanodine Ryr2 receptor as a candidate. Circulation. 103:442-447.
  • De Souza AI; Egdell RM; Zhao L; Sebkhi A; Wilkins MR; Nunez DJR; MacLeod KT. (1 Jan 2001). Differential cellular effects in left (LV) and right (RV) ventricular myocytes from a rat model of biventricular hypertrophy. BIOPHYSICAL JOURNAL. 80:580A-580A. Author weblink.
  • Zhao L; Mason NA; Wilkins MR. (1 Dec 2000). Sildenafil inhibits hypoxia-induced pulmonary hypertension in mice. THORAX. 55:A35-A35. Author weblink.
  • Sebkhi A; Zhao L; Lu L; Haley CS; Nunez DJR; Wilkins MR. (1 Apr 1999). Genetic determination of cardiac mass in normotensive rats - Results from an F344 x WKY cross. HYPERTENSION. 33:949-953. Author weblink.
  • Zhao L; Long L; Morrell NW; Wilkins MR. (9 Feb 1999). NPR-A-Deficient mice show increased susceptibility to hypoxia-induced pulmonary hypertension. Circulation. 99:605-607.
  • Zhao L; Brown LA; Owji AA; Nunez DJ; Smith DM; Ghatei MA; Bloom SR; Wilkins MR. (Aug 1996). Adrenomedullin activity in chronically hypoxic rat lungs. Am J Physiol. 271:H622-H629.
  • Zhao L; Hughes JM; Winter RJ. (Apr 1994). Reversal of pulmonary vascular remodelling following hypoxic exposure: no effect of infusion of atrial natriuretic factor and neutral endopeptidase inhibitor. Cardiovasc Res. 28:519-523.
  • Zhao L; Crawley DE; Hughes JM; Evans TW; Winter RJ. (Mar 1993). Endothelium-derived relaxing factor activity in rat lung during hypoxic pulmonary vascular remodeling. J Appl Physiol. 74:1061-1065.
  • Zhao L; Hughes JM; Winter RJ. (Nov 1992). Effects of natriuretic peptides and neutral endopeptidase 24.11 inhibition in isolated perfused rat lung. Am Rev Respir Dis. 146:1198-1201.
  • Crawley DE; Zhao L; Giembycz MA; Liu S; Barnes PJ; Winter RJ; Evans TW. (Sep 1992). Chronic hypoxia impairs soluble guanylyl cyclase-mediated pulmonary arterial relaxation in the rat. Am J Physiol. 263:L325-L332.
  • ZHAO L; HUGHES JMB; WINTER RJD. (1 Mar 1992). VASCULAR REACTIVITY TO BRAIN NATRIURETIC PEPTIDE IN THE ISOLATED AND BLOOD PERFUSED RAT LUNG. THORAX. 47:P226-P226. Author weblink.
  • ZHAO L; HUGHES JMB; WINTER RJD. (1 Mar 1992). RESOLUTION OF PULMONARY-HYPERTENSION, PULMONARY VASCULAR REMODELING AND RIGHT VENTRICULAR HYPERTROPHY INDUCED BY 7 DAY HYPOXIA IN RATS. THORAX. 47:P227-P227. Author weblink.
  • Winter RJ; Zhao L; Krausz T; Hughes JM. (Dec 1991). Neutral endopeptidase 24.11 inhibition reduces pulmonary vascular remodeling in rats exposed to chronic hypoxia. Am Rev Respir Dis. 144:1342-1346.
  • Zhao L; Winter RJ; Krausz T; Hughes JM. (Sep 1991). Effects of continuous infusion of atrial natriuretic peptide on the pulmonary hypertension induced by chronic hypoxia in rats. Clin Sci (Lond). 81:379-385.
  • ZHAO L; HUGHES JMB; WINTER RJD. (1 Jan 1991). VASCULAR REACTIVITY TO NEUTRAL ENDOPEPTIDASE 24.11 INHIBITION IN THE ISOLATED AND BLOOD-PERFUSED RAT LUNG. JOURNAL OF PHYSIOLOGY-LONDON. 438:P310-P310. Author weblink.
  • WINTER RJD; ZHAO L; KRAUSZ T; HUGHES JMB. (1 Oct 1990). CHRONIC INFUSION OF ATRIAL-NATRIURETIC-PEPTIDE ATTENUATES PULMONARY VASCULAR REMODELING IN RATS. CLINICAL SCIENCE. 79:P3-P3. Author weblink.

Chapters in books

  • Zhao, L. Pulmonary Vascular Remodelling. In Pulmonary Circulation. 87-95. Peacock AJ (ed). Chapman & Hall Medical, London (1996).

Conferences

  • Baliga R; Zhao L; Wilkins MR; MacAllister RJ; Hobbs AJ. Selective modulation of ANP-dependent dilation in the pulmonary vasculature by PDE 5 inhibitors: A novel combination therapy for pulmonary hypertension?. 80th Annual Scientific Session of the American-Heart-Association, 4 Nov 2007 - 7 Nov 2007. 116:456-456. LIPPINCOTT WILLIAMS & WILKINS (16 Oct 2007). Author weblink.
  • Zhao L; Bahaa F; Wilkins M. Tetrarydrobiopterin and pulmonary hypertension. NATO Advanced Research Workshop on Problems of High Altitude Medicine and Biology. 69-86. (2007).
  • Khoo JP; Zhao L; Alp NJ; Bendall JK; Rockett K; Wilkins MR; Channon KM. Prevention of hypoxia-induced pulmonary hypertension and vascular remodelling by targeting endothelial tetrahydrobiopterin-dependent nitric oxide synthase regulation. Annual Conference of G-MEX/MICC, 23 May 2005 - 26 May 2005. 91:A4-A4. B M J PUBLISHING GROUP (1 May 2005). Author weblink.
  • Khoo JP; Zhao L; Alp NJ; Bendall JK; Rockett K; Nicoli T; Wilkins MR; Channon KM. Tetrahydrobiopterin deficiency uncouples nitric oxide synthase and causes pulmonary hypertension. 77th Scientific Meeting of the American-Heart-Association, 7 Nov 2004 - 10 Nov 2004. 110:18-19. LIPPINCOTT WILLIAMS & WILKINS (26 Oct 2004). Author weblink.
  • Khoo JP; Zhao L; Alp NJ; Bendall J; Nicoll T; Wilkins MR; Channon KM. GTP cyclohydrolase I deficiency results in oxidative stress and pulmonary hypertension. ESC Congress 2004, 28 Aug 2004 - 1 Sep 2004. 25:84-84. W B SAUNDERS CO LTD (1 Aug 2004). Author weblink.
  • Khoo J; Zhao L; Alp NJ; Bendall J; Nicoli T; Wilkins MR; Channon KM. Tetrahydrobiopterin deficiency causes pulmonary hypertension: Effects on lung superoxide levels, hypoxic pulmonary vasoconstriction and vascular remodelling. Annual Conference of the British-Cardiac-Society. 90:A44-A44. (May 2004).
  • Zhao L; Mason NA; Strange J; Walker H; Wilkins MR. NPR-A deficient mice exhibit resistance to the effects of sildenafil in hypoxia-induced pulmonary hypertension. American-Heart-Association Abstracts From Scientific Sessions, 17 Nov 2002 - 20 Nov 2002. 106:340-340. LIPPINCOTT WILLIAMS & WILKINS (5 Nov 2002). Author weblink.
Share this on Delicious
Tweet this
Digg this
Stumble this
Share this on Facebook