Professor Marina Botto

Publications


Journals

  • Lewis MJ; Malik TH; Fossati-Jimack L; Carassiti D; Terence Cook H; Haskard DO; Botto M. (5 Mar 2012). Combining lupus and hyperlipidaemia in mice reveals distinct roles for complement in glomerulonephritis and atherosclerosis. Arthritis Rheum. DOI.
  • Menikou S; Patel MP; Rose KL; Botto M; Warner JO; Pickering MC; Boyle RJ. (2012). Relationship between complotype and severity of reported systemic allergic reactions to peanut. Journal of Allergy and Clinical Immunology.
  • Humphries MM; Kenna PF; Campbell M; Tam LCS; Nguyen ATH; Farrar GJ; Botto M; Kiang AS; et alHumphries P. (1 Jan 2012). C1q enhances cone photoreceptor survival in a mouse model of autosomal recessive retinitis pigmentosa. EUROPEAN JOURNAL OF HUMAN GENETICS. 20:64-68. Author weblink DOI.
  • Humphries MM; Kenna PF; Campbell M; Tam LCS; Nguyen ATH; Farrar GJ; Botto M; Kiang AS; et alHumphries P. (24 Aug 2011). C1q enhances cone photoreceptor survival in a mouse model of autosomal recessive retinitis pigmentosa. European Journal of Human Genetics.
  • Lunardi A; Gaboli M; Giorgio M; Rivi R; Bygrave A; Antoniou M; Drabek D; Dzierzak E; et alFagioli M; Salmena L; Botto M; Cordon-Cardo C; Luzzatto L; Pelicci PG; Grosveld F; Pandolfi PP. (2011). A Role for PML in Innate Immunity. Genes Cancer. 2:10-9.
  • Boross P; Arandhara VL; Martin-Ramirez J; Santiago-Raber M-L; Carlucci F; Flierman R; van der Kaa J; Breukel C; et alClaassens JWC; Camps M; Lubberts E; Salvatori D; Rastaldi MP; Ossendorp F; Daha MR; Cook HT; Izui S; Botto M; Verbeek JS. (1 Aug 2011). The Inhibiting Fc Receptor for IgG, Fc gamma RIIB, Is a Modifier of Autoimmune Susceptibility. JOURNAL OF IMMUNOLOGY. 187:1304-1313. DOI.
  • Ling GS; Cook HT; Botto M; Lau YL; Huang FP. (Oct 2011). An essential protective role of IL-10 in the immunological mechanism underlying resistance vs. susceptibility to lupus induction by dendritic cells and dying cells. Rheumatology (Oxford). 50:1773-1784. DOI.
  • McDonald JU; Cortini A; Rosas M; Fossati-Jimack L; Ling GS; Lewis KJ; Dewitt S; Liddiard K; et alBrown GD; Jones SA; Hallett MB; Botto M; Taylor PR. (Jun 2011). In vivo functional analysis and genetic modification of in vitro-derived mouse neutrophils. FASEB J. 25:1972-1982. DOI.
  • de Jorge EG; Macor P; Paixão-Cavalcante D; Rose KL; Tedesco F; Cook HT; Botto M; Pickering MC. (Jan 2011). The development of atypical hemolytic uremic syndrome depends on complement C5. J Am Soc Nephrol. 22:137-145. DOI.
  • Bodin K; Ellmerich S; Kahan MC; Tennent GA; Loesch A; Gilbertson JA; Hutchinson WL; Mangione PP; et alGallimore JR; Millar DJ; Minogue S; Dhillon AP; Taylor GW; Bradwell AR; Petrie A; Gillmore JD; Bellotti V; Botto M; Hawkins PN; Pepys MB. (4 Nov 2010). Antibodies to human serum amyloid P component eliminate visceral amyloid deposits. NATURE. 468:93-97. DOI.
  • Malik TH; Cortini A; Carassiti D; Boyle JJ; Haskard DO; Botto M. (9 Nov 2010). The alternative pathway is critical for pathogenic complement activation in endotoxin- and diet-induced atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation. 122:1948-1956. DOI.
  • Harhausen D; Prinz V; Ziegler G; Gertz K; Endres M; Lehrach H; Gasque P; Botto M; et alStahel PF; Dirnagl U; Nietfeld W; Trendelenburg G. (1 Jun 2010). CD93/AA4.1: A Novel Regulator of Inflammation in Murine Focal Cerebral Ischemia. JOURNAL OF IMMUNOLOGY. 184:6407-6417. Author weblink DOI.
  • Carlucci F; Fossati-Jimack L; Dumitriu IE; Heidari Y; Walport MJ; Szajna M; Baruah P; Garden OA; et alCook HT; Botto M. (1 Jun 2010). Identification and characterization of a lupus suppressor 129 locus on chromosome 3. J Immunol. 184:6256-6265. DOI.
  • Pickering MC; Botto M. (Aug 2010). Are anti-C1q antibodies different from other SLE autoantibodies?. Nat Rev Rheumatol. 6:490-493. DOI.
  • Baruah P; Simpson E; Dumitriu IE; Derbyshire K; Coe D; Addey C; Dyson J; Chai JG; et alCook T; Scott D; Botto M. (Jun 2010). Mice lacking C1q or C3 show accelerated rejection of minor H disparate skin grafts and resistance to induction of tolerance. Eur J Immunol. 40:1758-1767. DOI.
  • Lee HM; Wysoczynski M; Liu R; Shin D-M; Kucia M; Botto M; Ratajczak J; Ratajczak MZ. (1 Mar 2010). Mobilization studies in complement-deficient mice reveal that optimal AMD3100 mobilization of hematopoietic stem cells depends on complement cascade activation by AMD3100-stimulated granulocytes. LEUKEMIA. 24:573-582. DOI.
  • Ten VS; Yao J; Ratner V; Sosunov S; Fraser DA; Botto M; Sivasankar B; Morgan BP; et alSilverstein S; Stark R; Polin R; Vannucci SJ; Pinsky D; Starkov AA. (10 Feb 2010). Complement component c1q mediates mitochondria-driven oxidative stress in neonatal hypoxic-ischemic brain injury. J Neurosci. 30:2077-2087. DOI.
  • Carlucci F; Cook HT; Garg A; Pepys MB; Botto M. (Jan 2010). Lack of effect of a single injection of human C-reactive protein on murine lupus or nephrotoxic nephritis. Arthritis Rheum. 62:245-249. DOI.
  • Mehta P; Norsworthy PJ; Hall AE; Kelly SJ; Walport MJ; Botto M; Pickering MC. (Apr 2010). SLE with C1q deficiency treated with fresh frozen plasma: a 10-year experience. Rheumatology (Oxford). 49:823-824. DOI.
  • Leung VWY; Yun S; Botto M; Mason JC; Malik TH; Song W; Paixao-Cavalcante D; Pickering MC; et alBoyle JJ; Haskard DO. (1 Oct 2009). Decay-Accelerating Factor Suppresses Complement C3 Activation and Retards Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice. AMERICAN JOURNAL OF PATHOLOGY. 175:1757-1767. Author weblink DOI.
  • Tsoni SV; Kerrigan AM; Marakalala MJ; Srinivasan N; Duffield M; Taylor PR; Botto M; Steele C; et alBrown GD. (1 Sep 2009). Complement C3 Plays an Essential Role in the Control of Opportunistic Fungal Infections. INFECTION AND IMMUNITY. 77:3679-3685. Author weblink DOI.
  • Lewis MJ; Malik TH; Ehrenstein MR; Boyle JJ; Botto M; Haskard DO. (4 Aug 2009). Immunoglobulin M Is Required for Protection Against Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice. CIRCULATION. 120:417-U101. Author weblink DOI.
  • Botto M; Kirschfink M; Macor P; Pickering MC; Würzner R; Tedesco F. (Sep 2009). Complement in human diseases: Lessons from complement deficiencies. Mol Immunol. 46:2774-2783. DOI.
  • Woodman ME; Cooley AE; Avdiushko R; Bowman A; Botto M; Wooten RM; van Rooijen N; Cohen DA; et alStevenson B. (Sep 2009). Roles for phagocytic cells and complement in controlling relapsing fever infection. J Leukoc Biol. 86:727-736. DOI.
  • Paixão-Cavalcante D; Hanson S; Botto M; Cook HT; Pickering MC. (Jun 2009). Factor H facilitates the clearance of GBM bound iC3b by controlling C3 activation in fluid phase. Mol Immunol. 46:1942-1950. DOI.
  • Baruah P; Dumitriu IE; Malik TH; Cook HT; Dyson J; Scott D; Simpson E; Botto M. (9 Apr 2009). C1q enhances IFN-gamma production by antigen-specific T cells via the CD40 costimulatory pathway on dendritic cells. BLOOD. 113:3485-3493. Author weblink DOI.
  • Chevrier S; Genton C; Kallies A; Karnowski A; Otten LA; Malissen B; Malissen M; Botto M; et alCorcoran LM; Nutt SL; Acha-Orbea H. (10 Mar 2009). CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow niche. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 106:3895-3900. Author weblink DOI.
  • Paixao-Cavalcante D; Botto M; Cook HT; Pickering MC. (1 Feb 2009). Shiga toxin-2 results in renal tubular injury but not thrombotic microangiopathy in heterozygous factor H-deficient mice. CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 155:339-347. Author weblink DOI.
  • Heidari Y; Fossati-Jimack L; Carlucci F; Walport MJ; Cook HT; Botto M. (Jan 2009). A lupus-susceptibility C57BL/6 locus on chromosome 3 (Sle18) contributes to autoantibody production in 129 mice. Genes Immun. 10:47-55. DOI.
  • Pickering MC; Macor P; Fish J; Durigutto P; Bossi F; Petry F; Botto M; Tedesco F. (1 Oct 2008). Complement C1q and C8 beta deficiency in an individual with recurrent bacterial meningitis and adult-onset systemic lupus erythematosus-like illness. RHEUMATOLOGY. 47:1588-1589. Author weblink DOI.
  • Fossati-Jimack L; Cortes-Hernandez J; Norsworthy PJ; Cook HT; Walport MJ; Botto M. (1 Jul 2008). Regulation of B cell tolerance by 129-derived chromosome 1 loci in C57BL/6 mice. ARTHRITIS AND RHEUMATISM. 58:2131-2141. Author weblink DOI.
  • Yun S; Leung VW; Botto M; Boyle JJ; Haskard DO. (Oct 2008). Brief report: accelerated atherosclerosis in low-density lipoprotein receptor-deficient mice lacking the membrane-bound complement regulator CD59. Arterioscler Thromb Vasc Biol. 28:1714-1716. DOI.
  • Yuste J; Sen A; Truedsson L; Jönsson G; Tay LS; Hyams C; Baxendale HE; Goldblatt F; et alBotto M; Brown JS. (Aug 2008). Impaired opsonization with C3b and phagocytosis of Streptococcus pneumoniae in sera from subjects with defects in the classical complement pathway. Infect Immun. 76:3761-3770. DOI.
  • Rose KL; Paixao-Cavalcante D; Fish J; Manderson AP; Malik TH; Bygrave AE; Lin T; Sacks SH; et alWalport MJ; Cook HT; Botto M; Pickering MC. (1 Feb 2008). Factor I is required for the development of membranoproliferative glomerulonephritis in factor H-deficient mice. JOURNAL OF CLINICAL INVESTIGATION. 118:608-618. Author weblink DOI.
  • Giacomin PR; Gordon DL; Botto M; Daha MR; Sanderson SD; Taylor SM; Dent LA. (1 Jan 2008). The role of complement in innate, adaptive and eosinophil-dependent immunity to the nematode Nippostrongylus brasiliensis. MOLECULAR IMMUNOLOGY. 45:446-455. Author weblink DOI.
  • Yuste J; Botto M; Bottoms SE; Brown JS. (1 Sep 2007). Serum amyloid P aids complement-mediated immunity to Streptococcus pneumoniae. PLOS PATHOGENS. 3:1208-1219. Author weblink DOI.
  • Rose KL; Paixao-Cavalcante D; Fish J; Manderson AP; Malik T; Bygrave AE; Lin T; Sacks SH; et alWalport MJ; Cook HT; Botto M; Pickering MC. (1 Sep 2007). Factor I is required for the development of membranoproliferative glomerulonephritis in factor H-deficient mice. MOLECULAR IMMUNOLOGY. 44:3924-3924. Author weblink DOI.
  • Hepburn AL; Lampert IA; Boyle JJ; Horncastle D; Ng WF; Layton M; Vyse TJ; Botto M; et alMason JC. (1 Aug 2007). In vivo evidence for apoptosis in the bone marrow in systemic lupus erythematosus. ANNALS OF THE RHEUMATIC DISEASES. 66:1106-1109. Author weblink DOI.
  • Fossati-Jimack L; Cortes-Hernandez J; Norsworthy PJ; Walport MJ; Cook HT; Botto M. (Feb 2008). C1q deficiency promotes the production of transgenic-derived IgM and IgG3 autoantibodies in anti-DNA knock-in transgenic mice. Mol Immunol. 45:787-795. DOI.
  • Smith RJ; Alexander J; Barlow PN; Botto M; Cassavant TL; Cook HT; de Córdoba SR; Hageman GS; et alJokiranta TS; Kimberling WJ; Lambris JD; Lanning LD; Levidiotis V; Licht C; Lutz HU; Meri S; Pickering MC; Quigg RJ; Rops AL; Salant DJ; Sethi S; Thurman JM; Tully HF; Tully SP; van der Vlag J; Walker PD; Würzner R; Zipfel PF; Dense Deposit Disease Focus Group. (Sep 2007). New approaches to the treatment of dense deposit disease. J Am Soc Nephrol. 18:2447-2456. DOI.
  • Mihai S; Chiriac MT; Takahashi K; Thurman JM; Holers VM; Zillikens D; Botto M; Sitaru C. (15 May 2007). The alternative pathway of complement activation is critical for blister induction in experimental epidermolysis bullosa acquisita. JOURNAL OF IMMUNOLOGY. 178:6514-6521. Author weblink.
  • Pickering MC; de Jorge EG; Martinez-Barricarte R; Recalde S; Garcia-Layana A; Rose KL; Moss J; Walport MJ; et alCook HT; de Córdoba SR; Botto M. (11 Jun 2007). Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domains. J Exp Med. 204:1249-1256. DOI.
  • Woodman ME; Cooley AE; Miller JC; Lazarus JJ; Tucker K; Bykowski T; Botto M; Hellwage J; et alWooten RM; Stevenson B. (Jun 2007). Borrelia burgdorferi binding of host complement regulator factor H is not required for efficient mammalian infection. Infect Immun. 75:3131-3139. DOI.
  • Ferry H; Potter PK; Crockford TL; Nijnik A; Ehrenstein MR; Walport MJ; Botto M; Cornall RJ. (1 Mar 2007). Increased positive selection of B1 cells and reduced B cell tolerance to intracellular antigens in C1q-deficient mice. JOURNAL OF IMMUNOLOGY. 178:2916-2922. Author weblink.
  • Carlucci F; Cortes-Hernandez J; Fossati-Jimack L; Bygrave AE; Walport MJ; Vyse TJ; Cook HT; Botto M. (15 Feb 2007). Genetic dissection of spontaneous autoimmunity driven by 129-derived chromosome 1 Loci when expressed on C57BL/6 mice. J Immunol. 178:2352-2360.
  • Rupprecht TA; Angele B; Klein M; Heesemann J; Pfister H-W; Botto M; Koedel U. (1 Feb 2007). Complement C1q and C3 are critical for the innate immune response to Streptococcus pneumoniae in the central nervous system. JOURNAL OF IMMUNOLOGY. 178:1861-1869. Author weblink.
  • Taylor PR; Tsoni SV; Willment JA; Dennehy KM; Rosas M; Findon H; Haynes K; Steele C; et alBotto M; Gordon S; Brown GD. (1 Jan 2007). Dectin-1 is required for beta-glucan recognition and control of fungal infection. NATURE IMMUNOLOGY. 8:31-38. Author weblink DOI.
  • Manderson AP; Quah B; Botto M; Goodnow CC; Walport MJ; Parish CR. (15 Oct 2006). A novel mechanism for complement activation at the surface of B cells following antigen binding. JOURNAL OF IMMUNOLOGY. 177:5155-5162. Author weblink.
  • Heidari Y; Bygrave AE; Rigby RJ; Rose KL; Walport MJ; Cook HT; Vyse TJ; Botto M. (Oct 2006). Identification of chromosome intervals from 129 and C57BL/6 mouse strains linked to the development of systemic lupus erythematosus. Genes Immun. 7:592-599. DOI.
  • Turnberg D; Lewis M; Moss J; Xu Y; Botto M; Cook HT. (15 Sep 2006). Complement activation contributes to both glomerular and tubulointerstitial damage in adriamycin nephropathy in mice. J Immunol. 177:4094-4102.
  • Lewis MJ; Botto M. (Aug 2006). Complement deficiencies in humans and animals: links to autoimmunity. Autoimmunity. 39:367-378. DOI.
  • Gaspal FMC; McConnell FM; Kim M-Y; Gray D; Kosco-Vilbois MH; Raykundalia CR; Botto M; Lane PJL. (1 Jul 2006). The generation of thymus-independent germinal centers depends on CD40 but not on CD154, the T cell-derived CD40-ligand. EUROPEAN JOURNAL OF IMMUNOLOGY. 36:1665-1673. Author weblink DOI.
  • Potter PK; Larbi KY; Nourshargh S; Botto M. (Feb 2007). Efficient clearance of opsonised apoptotic cells in the absence of PECAM-1. Mol Immunol. 44:1135-1140. DOI.
  • Cook HT; Botto M. (1 Jun 2006). Mechanisms of disease: the complement system and the pathogenesis of systemic lupus erythematosus. NATURE CLINICAL PRACTICE RHEUMATOLOGY. 2:330-337. Author weblink DOI.
  • Pickering MC; Warren J; Rose KL; Carlucci F; Wang Y; Walport MJ; Cook HT; Botto M. (20 Jun 2006). Prevention of C5 activation ameliorates spontaneous and experimental glomerulonephritis in factor H-deficient mice. Proc Natl Acad Sci U S A. 103:9649-9654. DOI.
  • Yuste J; Ali S; Sriskandan S; Hyams C; Botto M; Brown JS. (15 May 2006). Roles of the alternative complement pathway and C1q during innate immunity to Streptococcus pyogenes. JOURNAL OF IMMUNOLOGY. 176:6112-6120. Author weblink.
  • Manderson AP; Carlucci F; Lachmann PJ; Lazarus RA; Festenstein RJ; Cook HT; Walport MJ; Botto M. (2006). The in vivo expression of actin/salt-resistant hyperactive DNase I inhibits the development of anti-ssDNA and anti-histone autoantibodies in a murine model of systemic lupus erythematosus. Arthritis Res Ther. 8:R68. DOI.
  • Tas SW; Quartier P; Botto M; Fossati-Jimack L. (Feb 2006). Macrophages from patients with SLE and rheumatoid arthritis have defective adhesion in vitro, while only SLE macrophages have impaired uptake of apoptotic cells. Ann Rheum Dis. 65:216-221. DOI.
  • Trendelenburg M; Fossati-Jimack L; Cortes-Hernandez J; Turnberg D; Lewis M; Izui S; Cook HT; Botto M. (15 Nov 2005). The role of complement in cryoglobulin-induced immune complex glomerulonephritis. J Immunol. 175:6909-6914.
  • Giacomin PR; Wang H; Gordon DL; Botto M; Dent LA. (Nov 2005). Loss of complement activation and leukocyte adherence as Nippostrongylus brasiliensis develops within the murine host. Infect Immun. 73:7442-7449. DOI.
  • Ten VS; Sosunov SA; Mazer SP; Stark RI; Caspersen C; Sughrue ME; Botto M; Connolly ES; et alPinsky DJ. (Oct 2005). C1q-deficiency is neuroprotective against hypoxic-ischemic brain injury in neonatal mice. Stroke. 36:2244-2250. DOI.
  • Yuste J; Botto M; Paton JC; Holden DW; Brown JS. (1 Aug 2005). Additive inhibition of complement deposition by pneumolysin and PspA facilitates Streptococcus pneumoniae septicemia. J Immunol. 175:1813-1819.
  • Exley RM; Shaw J; Mowe E; Sun YH; West NP; Williamson M; Botto M; Smith H; et alTang CM. (16 May 2005). Available carbon source influences the resistance of Neisseria meningitidis against complement. J Exp Med. 201:1637-1645. DOI.
  • Monk CR; Spachidou M; Rovis F; Leung E; Botto M; Lechler RI; Garden OA. (Apr 2005). MRL/Mp CD4+,CD25- T cells show reduced sensitivity to suppression by CD4+,CD25+ regulatory T cells in vitro: a novel defect of T cell regulation in systemic lupus erythematosus. Arthritis Rheum. 52:1180-1184. DOI.
  • Quartier P; Potter PK; Ehrenstein MR; Walport MJ; Botto M. (Jan 2005). Predominant role of IgM-dependent activation of the classical pathway in the clearance of dying cells by murine bone marrow-derived macrophages in vitro. Eur J Immunol. 35:252-260. DOI.
  • Cortes-Hernandez J; Fossati-Jimack L; Petry F; Loos M; Izui S; Walport MJ; Cook HT; Botto M. (Dec 2004). Restoration of C1q levels by bone marrow transplantation attenuates autoimmune disease associated with C1q deficiency in mice. Eur J Immunol. 34:3713-3722. DOI.
  • Stokol T; O'Donnell P; Xiao L; Knight S; Stavrakis G; Botto M; von Andrian UH; Mayadas TN. (4 Oct 2004). C1q governs deposition of circulating immune complexes and leukocyte Fcgamma receptors mediate subsequent neutrophil recruitment. J Exp Med. 200:835-846. DOI.
  • Turnberg D; Botto M; Lewis M; Zhou W; Sacks SH; Morgan BP; Walport MJ; Cook HT. (Sep 2004). CD59a deficiency exacerbates ischemia-reperfusion injury in mice. Am J Pathol. 165:825-832. DOI.
  • Trendelenburg M; Manderson AP; Fossati-Jimack L; Walport MJ; Botto M. (Sep 2004). Monocytosis and accelerated activation of lymphocytes in C1q-deficient autoimmune-prone mice. Immunology. 113:80-88. DOI.
  • Bygrave AE; Rose KL; Cortes-Hernandez J; Warren J; Rigby RJ; Cook HT; Walport MJ; Vyse TJ; et alBotto M. (Aug 2004). Spontaneous autoimmunity in 129 and C57BL/6 mice-implications for autoimmunity described in gene-targeted mice. PLoS Biol. 2:E243. DOI.
  • Fonseca MI; Zhou J; Botto M; Tenner AJ. (21 Jul 2004). Absence of C1q leads to less neuropathology in transgenic mouse models of Alzheimer's disease. J Neurosci. 24:6457-6465. DOI.
  • Hutchinson WL; Herbert J; Botto M; Pepys MB. (Jun 2004). Classical and alternative pathway complement activation are not required for reactive systemic AA amyloid deposition in mice. Immunology. 112:250-254. DOI.
  • Norsworthy PJ; Fossati-Jimack L; Cortes-Hernandez J; Taylor PR; Bygrave AE; Thompson RD; Nourshargh S; Walport MJ; et alBotto M. (15 Mar 2004). Murine CD93 (C1qRp) contributes to the removal of apoptotic cells in vivo but is not required for C1q-mediated enhancement of phagocytosis. J Immunol. 172:3406-3414.
  • Yamada M; Oritani K; Kaisho T; Ishikawa J; Yoshida H; Takahashi I; Kawamoto S; Ishida N; et alUjiie H; Masaie H; Botto M; Tomiyama Y; Matsuzawa Y. (Jan 2004). Complement C1q regulates LPS-induced cytokine production in bone marrow-derived dendritic cells. Eur J Immunol. 34:221-230. DOI.
  • Mead RJ; Neal JW; Griffiths MR; Linington C; Botto M; Lassmann H; Morgan BP. (Jan 2004). Deficiency of the complement regulator CD59a enhances disease severity, demyelination and axonal injury in murine acute experimental allergic encephalomyelitis. Lab Invest. 84:21-28. DOI.
  • Botto M. (2004). Phosphatidylserine receptor and apoptosis: consequences of a non-ingested meal. Arthritis Res Ther. 6:147-150. DOI.
  • Manderson AP; Botto M; Walport MJ. (2004). The role of complement in the development of systemic lupus erythematosus. Annu Rev Immunol. 22:431-456. DOI.
  • Stäger S; Alexander J; Kirby AC; Botto M; Rooijen NV; Smith DF; Brombacher F; Kaye PM. (Oct 2003). Natural antibodies and complement are endogenous adjuvants for vaccine-induced CD8+ T-cell responses. Nat Med. 9:1287-1292. DOI.
  • Turnberg D; Botto M; Warren J; Morgan BP; Walport MJ; Cook HT. (Sep 2003). CD59a deficiency exacerbates accelerated nephrotoxic nephritis in mice. J Am Soc Nephrol. 14:2271-2279.
  • Turnberg D; Botto M. (Sep 2003). The regulation of the complement system: insights from genetically-engineered mice. Mol Immunol. 40:145-153.
  • Di Gaetano N; Cittera E; Nota R; Vecchi A; Grieco V; Scanziani E; Botto M; Introna M; et alGolay J. (1 Aug 2003). Complement activation determines the therapeutic activity of rituximab in vivo. J Immunol. 171:1581-1587.
  • Potter PK; Cortes-Hernandez J; Quartier P; Botto M; Walport MJ. (15 Mar 2003). Lupus-prone mice have an abnormal response to thioglycolate and an impaired clearance of apoptotic cells. J Immunol. 170:3223-3232.
  • Brown JS; Hussell T; Gilliland SM; Holden DW; Paton JC; Ehrenstein MR; Walport MJ; Botto M. (24 Dec 2002). The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice. Proc Natl Acad Sci U S A. 99:16969-16974. DOI.
  • Cortes-Hernandez J; Fossati-Jimack L; Carugati A; Potter PK; Walport MJ; Cook HT; Botto M. (Dec 2002). Murine glomerular mesangial cell uptake of apoptotic cells is inefficient and involves serum-mediated but complement-independent mechanisms. Clin Exp Immunol. 130:459-466.
  • Garlanda C; Hirsch E; Bozza S; Salustri A; De Acetis M; Nota R; Maccagno A; Riva F; et alBottazzi B; Peri G; Doni A; Vago L; Botto M; De Santis R; Carminati P; Siracusa G; Altruda F; Vecchi A; Romani L; Mantovani A. (14 Nov 2002). Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response. Nature. 420:182-186. DOI.
  • Vandivier RW; Ogden CA; Fadok VA; Hoffmann PR; Brown KK; Botto M; Walport MJ; Fisher JH; et alHenson PM; Greene KE. (1 Oct 2002). Role of surfactant proteins A, D, and C1q in the clearance of apoptotic cells in vivo and in vitro: calreticulin and CD91 as a common collectin receptor complex. J Immunol. 169:3978-3986.
  • Botto M; Walport MJ. (Sep 2002). C1q, autoimmunity and apoptosis. Immunobiology. 205:395-406.
  • Pickering MC; Cook HT; Warren J; Bygrave AE; Moss J; Walport MJ; Botto M. (Aug 2002). Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H. Nat Genet. 31:424-428. DOI.
  • Taylor PR; Pickering MC; Kosco-Vilbois MH; Walport MJ; Botto M; Gordon S; Martinez-Pomares L. (Jul 2002). The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues. Eur J Immunol. 32:1888-1896. DOI.
  • Azeredo da Silveira S; Kikuchi S; Fossati-Jimack L; Moll T; Saito T; Verbeek JS; Botto M; Walport MJ; et alCarroll M; Izui S. (18 Mar 2002). Complement activation selectively potentiates the pathogenicity of the IgG2b and IgG3 isotypes of a high affinity anti-erythrocyte autoantibody. J Exp Med. 195:665-672.
  • Mitchell DA; Pickering MC; Warren J; Fossati-Jimack L; Cortes-Hernandez J; Cook HT; Botto M; Walport MJ. (1 Mar 2002). C1q deficiency and autoimmunity: the effects of genetic background on disease expression. J Immunol. 168:2538-2543.
  • Warren J; Mastroeni P; Dougan G; Noursadeghi M; Cohen J; Walport MJ; Botto M. (Feb 2002). Increased susceptibility of C1q-deficient mice to Salmonella enterica serovar Typhimurium infection. Infect Immun. 70:551-557.
  • Celik I; Stover C; Botto M; Thiel S; Tzima S; Künkel D; Walport M; Lorenz W; et alSchwaeble W. (Dec 2001). Role of the classical pathway of complement activation in experimentally induced polymicrobial peritonitis. Infect Immun. 69:7304-7309. DOI.
  • Petry F; Botto M; Holtappels R; Walport MJ; Loos M. (1 Oct 2001). Reconstitution of the complement function in C1q-deficient (C1qa-/-) mice with wild-type bone marrow cells. J Immunol. 167:4033-4037.
  • Manderson AP; Pickering MC; Botto M; Walport MJ; Parish CR. (17 Sep 2001). Continual low-level activation of the classical complement pathway. J Exp Med. 194:747-756.
  • Holt DS; Botto M; Bygrave AE; Hanna SM; Walport MJ; Morgan BP. (15 Jul 2001). Targeted deletion of the CD59 gene causes spontaneous intravascular hemolysis and hemoglobinuria. Blood. 98:442-449.
  • Cutler AJ; Cornall RJ; Ferry H; Manderson AP; Botto M; Walport MJ. (Jul 2001). Intact B cell tolerance in the absence of the first component of the classical complement pathway. Eur J Immunol. 31:2087-2093. DOI.
  • Pickering MC; Fischer S; Lewis MR; Walport MJ; Botto M; Cook HT. (Jul 2001). Ultraviolet-radiation-induced keratinocyte apoptosis in C1q-deficient mice. J Invest Dermatol. 117:52-58. DOI.
  • Robson MG; Cook HT; Botto M; Taylor PR; Busso N; Salvi R; Pusey CD; Walport MJ; et alDavies KA. (1 Jun 2001). Accelerated nephrotoxic nephritis is exacerbated in C1q-deficient mice. J Immunol. 166:6820-6828.
  • Taylor PR; Seixas E; Walport MJ; Langhorne J; Botto M. (Jun 2001). Complement contributes to protective immunity against reinfection by Plasmodium chabaudi chabaudi parasites. Infect Immun. 69:3853-3859. DOI.
  • Klein MA; Kaeser PS; Schwarz P; Weyd H; Xenarios I; Zinkernagel RM; Carroll MC; Verbeek JS; et alBotto M; Walport MJ; Molina H; Kalinke U; Acha-Orbea H; Aguzzi A. (Apr 2001). Complement facilitates early prion pathogenesis. Nat Med. 7:488-492. DOI.
  • Mabbott NA; Bruce ME; Botto M; Walport MJ; Pepys MB. (Apr 2001). Temporary depletion of complement component C3 or genetic deficiency of C1q significantly delays onset of scrapie. Nat Med. 7:485-487. DOI.
  • Nash JT; Taylor PR; Botto M; Norsworthy PJ; Davies KA; Walport MJ. (Feb 2001). Immune complex processing in C1q-deficient mice. Clin Exp Immunol. 123:196-202.
  • Botto M. (2001). Links between complement deficiency and apoptosis. Arthritis Res. 3:207-210.
  • Perraudeau M; Taylor PR; Stauss HJ; Lindstedt R; Bygrave AE; Pappin DJ; Ellmerich S; Whitten A; et alRahman D; Canas B; Walport MJ; Botto M; Altmann DM. (Oct 2000). Altered major histocompatibility complex class II peptide loading in H2-O-deficient mice. Eur J Immunol. 30:2871-2880. DOI.
  • Taylor PR; Carugati A; Fadok VA; Cook HT; Andrews M; Carroll MC; Savill JS; Henson PM; et alBotto M; Walport MJ. (7 Aug 2000). A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo. J Exp Med. 192:359-366.
  • Bygrave AE; Botto M. (2000). Knocking out complement genes. Methods Mol Biol. 150:215-228. DOI.
  • Pickering MC; Botto M; Taylor PR; Lachmann PJ; Walport MJ. (2000). Systemic lupus erythematosus, complement deficiency, and apoptosis. Adv Immunol. 76:227-324.
  • Norsworthy P; Theodoridis E; Botto M; Athanassiou P; Beynon H; Gordon C; Isenberg D; Walport MJ; et alDavies KA. (Sep 1999). Overrepresentation of the Fcgamma receptor type IIA R131/R131 genotype in caucasoid systemic lupus erythematosus patients with autoantibodies to C1q and glomerulonephritis. Arthritis Rheum. 42:1828-1832. DOI.
  • Norsworthy PJ; Taylor PR; Walport MJ; Botto M. (Aug 1999). Cloning of the mouse homolog of the 126-kDa human C1q/MBL/SP-A receptor, C1qR(p). Mamm Genome. 10:789-793.
  • Naughton MA; Battaglia E; O'Brien S; Walport MJ; Botto M. (Jul 1999). Identification of thiopurine methyltransferase (TPMT) polymorphisms cannot predict myelosuppression in systemic lupus erythematosus patients taking azathioprine. Rheumatology (Oxford). 38:640-644.
  • Robson MG; Cook HT; Botto M; Pusey CD; Walport MJ; Davies KA. (1 Jun 1999). C1q deficient mice develop severe disease in accelerated nephrotoxic nephritis. KIDNEY INTERNATIONAL. 55:2593-2593. Author weblink.
  • Bickerstaff MC; Botto M; Hutchinson WL; Herbert J; Tennent GA; Bybee A; Mitchell DA; Cook HT; et alButler PJ; Walport MJ; Pepys MB. (Jun 1999). Serum amyloid P component controls chromatin degradation and prevents antinuclear autoimmunity. Nat Med. 5:694-697. DOI.
  • Mitchell DA; Taylor PR; Cook HT; Moss J; Bygrave AE; Walport MJ; Botto M. (15 May 1999). Cutting edge: C1q protects against the development of glomerulonephritis independently of C3 activation. J Immunol. 162:5676-5679.
  • Walport MJ; Davies KA; Botto M. (Aug 1998). C1q and systemic lupus erythematosus. Immunobiology. 199:265-285.
  • Cutler AJ; Botto M; van Essen D; Rivi R; Davies KA; Gray D; Walport MJ. (1 Jun 1998). T cell-dependent immune response in C1q-deficient mice: defective interferon gamma production by antigen-specific T cells. J Exp Med. 187:1789-1797.
  • Botto M; Dell'Agnola C; Bygrave AE; Thompson EM; Cook HT; Petry F; Loos M; Pandolfi PP; et alWalport MJ. (May 1998). Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies. Nat Genet. 19:56-59. DOI.
  • Taylor P; Botto M; Walport M. (9 Apr 1998). The complement system. Curr Biol. 8:R259-R261.
  • Robson MG; Cook HT; Botto M; Pusey CD; Walport MJ; Davies KA. (1 Apr 1998). Delayed resolution of inflammation in heterologous nephrotoxic nephritis in Clq deficient mice. MOLECULAR IMMUNOLOGY. 35:343-343. DOI.
  • Taylor PR; Nash JT; Theodoridis E; Bygrave AE; Walport MJ; Botto M. (16 Jan 1998). A targeted disruption of the murine complement factor B gene resulting in loss of expression of three genes in close proximity, factor B, C2, and D17H6S45. J Biol Chem. 273:1699-1704.
  • Botto M. (1998). C1q knock-out mice for the study of complement deficiency in autoimmune disease. Exp Clin Immunogenet. 15:231-234.
  • Taylor PR; Slingsby JH; Walport MJ; Botto M. (Oct 1997). Murine D17H6S45 (Rd) gene: polymorphism and overlap with complement factor B. Mamm Genome. 8:796-797.
  • Botto M; Hawkins PN; Bickerstaff MC; Herbert J; Bygrave AE; McBride A; Hutchinson WL; Tennent GA; et alWalport MJ; Pepys MB. (Aug 1997). Amyloid deposition is delayed in mice with targeted deletion of the serum amyloid P component gene. Nat Med. 3:855-859.
  • Walport MJ; Davies KA; Morley BJ; Botto M. (5 Apr 1997). Complement deficiency and autoimmunity. Ann N Y Acad Sci. 815:267-281.
  • NasonBurchenal K; Gandini D; Botto M; Allopenna J; Seale JRC; Cross NCP; Goldman JM; Dmitrovsky E; et alPandolfi PP. (15 Nov 1996). Interferon augments PML and PML/RAR alpha expression in normal myeloid and acute promyelocytic cells and cooperates with all-trans retinoic acid to induce maturation of a retinoid-resistant promyelocytic cell line. BLOOD. 88:3926-3936. Author weblink.
  • Naughton MA; Walport MJ; Würzner R; Carter MJ; Alexander GJ; Goldman JM; Botto M. (Sep 1996). Organ-specific contribution to circulating C7 levels by the bone marrow and liver in humans. Eur J Immunol. 26:2108-2112. DOI.
  • Botto M; Theodoridis E; Thompson EM; Beynon HL; Briggs D; Isenberg DA; Walport MJ; Davies KA. (May 1996). Fc gamma RIIa polymorphism in systemic lupus erythematosus (SLE): no association with disease. Clin Exp Immunol. 104:264-268.
  • Naughton MA; Botto M; Carter MJ; Alexander GJ; Goldman JM; Walport MJ. (15 Apr 1996). Extrahepatic secreted complement C3 contributes to circulating C3 levels in humans. J Immunol. 156:3051-3056.
  • Petry F; McClive PJ; Botto M; Morley BJ; Morahan G; Loos M. (1 Jan 1996). The mouse C1q genes are clustered on chromosome 4 and show conservation of gene organization. IMMUNOGENETICS. 43:370-376. Author weblink DOI.
  • HOHLER T; BOTTO M; RITTNER C; SCHNEIDER PM; ZUMBUSCHENFELDE KHM. (1 Nov 1995). COMPLEMENT COMPONENT C3 - MOLECULAR-BASIS OF THE C3-ASTERISK-S025 VARIANT AND EVIDENCE FOR MOLECULAR HETEROGENEITY OF OTHER VARIANTS. HUMAN GENETICS. 96:539-541. Author weblink.
  • Walport MJ; Davies KA; Botto M; Naughton MA; Isenberg DA; Biasi D; Powell RJ; Cheung NT; et alStruthers GR. (Oct 1994). C3 nephritic factor and SLE: report of four cases and review of the literature. QJM. 87:609-615.
  • BOTTO M; LISSANDRINI D; SORIO C; WALPORT MJ. (15 Aug 1992). BIOSYNTHESIS AND SECRETION OF COMPLEMENT COMPONENT (C3) BY ACTIVATED HUMAN POLYMORPHONUCLEAR LEUKOCYTES. JOURNAL OF IMMUNOLOGY. 149:1348-1355. Author weblink.
  • Botto M; Fong KY; So AK; Barlow R; Routier R; Morley BJ; Walport MJ. (1 Jun 1992). Homozygous hereditary C3 deficiency due to a partial gene deletion. Proc Natl Acad Sci U S A. 89:4957-4961.
  • BOTTO M; FONG KY; SO AK; RUDGE A; WALPORT MJ. (1 Oct 1990). MOLECULAR-BASIS OF HEREDITARY C3 DEFICIENCY. JOURNAL OF CLINICAL INVESTIGATION. 86:1158-1163. Author weblink DOI.
  • BOTTO M; FONG KY; SO AK; KOCH C; WALPORT MJ. (1 Oct 1990). MOLECULAR-BASIS OF POLYMORPHISMS OF HUMAN-COMPLEMENT COMPONENT-C3. JOURNAL OF EXPERIMENTAL MEDICINE. 172:1011-1017. Author weblink DOI.
  • BOTTO M; FONG KY; SO AK. (11 May 1990). ECORI POLYMORPHISM IN THE HUMAN 3RD COMPLEMENT COMPONENT (C3) GENE. NUCLEIC ACIDS RESEARCH. 18:2833-2833. DOI.
  • Botto M; Fong KY; So AK. (11 May 1990). EcoRI polymorphism in the human third complement component (C3) gene. Nucleic Acids Res. 18:2833.
  • Botto M; So AK; Giles CM; Mason PD; Walport MJ. (May 1990). HLA class I expression on erythrocytes and platelets from patients with systemic lupus erythematosus, rheumatoid arthritis and from normal subjects. Br J Haematol. 75:106-111.
  • Giles CM; Botto M; King MJ. (Feb 1990). A study of HLA (Bg) on red cells and platelets by immunoblotting with monoclonal antibodies. Transfusion. 30:126-132.
  • Giles CM; Darke C; Rowe GP; Botto M. (1989). HLA class I (Bg) antigens on red cells of SLE patients: a serological study with polyclonal and monoclonal antibodies. Vox Sang. 56:254-261.
  • Moldenhauer F; Botto M; Walport MJ. (Apr 1988). The rate of loss of CR1 from ageing erythrocytes in vivo in normal subjects and SLE patients: no correlation with structural or numerical polymorphisms. Clin Exp Immunol. 72:74-78.

Conferences

  • Menikou S; Warner JO; Botto M; Pickering MC; Boyle RJ. The role of the complotype in determining the severity of systemic allergic reactions to peanuts. Annual Meeting of the British-Society-for-Allergy-and-Clinical-Immunology (BSACI), 11 Jul 2011 - 13 Jul 2011. 41:1860-1861. WILEY-BLACKWELL (1 Dec 2011). Author weblink.
  • Botto M; Kirschfink M; Macor P; Pickering MC; Wuerzner R; Tedesco F. Complement in human diseases: Lessons from complement deficiencies. 12th European Meeting on Complement in Human Disease, 5 Sep 2009 - 8 Sep 2009. 46:2774-2783. PERGAMON-ELSEVIER SCIENCE LTD (1 Sep 2009). Author weblink DOI.
  • Vandiver RW; Botto M; Taylor PL; Ogden CA; Fadok VA; Walport MJ; Henson PM. Homozygous C1qa deficiency alters pulmonary clearance of apoptotic cells. 43rd Annual Thomas L Petty Aspen Lung Conference: Mechanisms of Pulmonary Fribrosis. 120:25S-26S. (Jul 2001).
  • Gillmore JD; Hutchinson WL; Mitchell DA; Herbert J; Botto M; Walport MJ; Pepys MB. Studies of serum amyloid P component (SAP) and antinuclear autoimmunity. 36th Annual Meeting of the American-Society-of-Nephrology. 14:167A-168A. (Nov 2003).
  • Hepburn AL; Ng WF; Layton M; Lampert IA; Botto M; Mason JC. In vivo evidence for apoptosis in the bone marrow in SLE. Joint Meeting of the British-Society-for-Rheumatology/Deutsche-Gesellschaft-fur-Rheumatologie and Spring Meeting of the British-Health-Professionals-in-Rheumatology. 44:I135-I135. (Mar 2005).
  • Giacomin PR; Wang H; Gordon DL; Botto M; Dent LA. Role of complement in innate immunity to the nematode Nippostrongylus Brasiliensis. 35th Annual SCientific Meeting of the Australasian-Society-for-Immunology/14th International HLA and Immunogenetics Workshops. 66:427-427. (Nov 2005).
  • Carlucci F; Cortes-Hernandez J; Fossati-Jimack LM; Bygrave AE; Cook TH; Vyse TJ; Botto M. Genetic contribution of 129 chromosome 1 intervals to autoimmunity in C57BL/6 mice. BSR Annual Meeting/BHPR Spring Meeting. 45:I4-I4. (Apr 2006).
  • Pickering MC; Fish J; Macor P; Durigutto P; Bossi F; Botto M; Tedesco F. Combined C1q and C8 beta deficiency in a patient with recurrent childhood infections and adult-onset systemic lupus erythematosus. 21st International Complement Workshop. 44:228-228. (Jan 2007).
  • Pickering MC; Rose KL; Carlucci F; Howard J; Cook HT; Botto M. Increased susceptibility of heterozygous factor H deficient mice to accelerated serum nephrotoxic nephritis. 21st International Complement Workshop. 44:228-228. (Jan 2007).
  • Giacomin P; Gordon D; Botto M; Dent L. The role of complement in innate, acquired and eosinophil-mediated immunity to the nematode Nippostrongylus brasiliensis. 21st International Complement Workshop. 44:176-177. (Jan 2007).
  • Fossati-Jimack L; Cortes-Hernandez J; Norsworthy P; Cook HT; Botto M. C1q can alter the levels of IgM autoantibody production in anti-DNA transgenic models. 21st International Complement Workshop. 44:171-171. (Jan 2007).
  • Mihai S; Chiriac MT; Takahashi K; Thurman JM; Holers VM; Botto M; Zillikens D; Sitaru C. The alternative pathway of complement activation is critical for the induction of experimental epidermolysis bullosa acquisita. 36th Annual Meeting of the European-Society-of-Dermatology-Research (ESDR), 6 Sep 2006 - 7 Sep 2006. 126:21-21. NATURE PUBLISHING GROUP (1 Aug 2006). Author weblink.
  • Pickering MC; de Jorge EG; Rose KL; Moss J; Cook HT; de Cordoba SR; Botto M. Spontaneous haemolytic uraemic syndrome (HUS) in factor H-deficient mice transgenic for murine factor H protein lacking the five C-terminal domains (FH Delta 16-20). 21st International Complement Workshop, 22 Oct 2006 - 26 Oct 2006. 44:227-228. PERGAMON-ELSEVIER SCIENCE LTD (1 Jan 2007). Author weblink DOI.
  • Bhatia V; Boyle JJ; Roberts CE; Sadler Y; Witztum JL; Benson G; Botto M; Haskard DO. Complement Clq plays a bidirectional role in early atherosclerotic lesions in LDL receptor knock-out mice. 189th Meeting of the Pathological-Society-of-Great-Britain-and-Ireland, 4 Jan 2006 - 6 Jan 2006. 208:31A-31A. JOHN WILEY & SONS LTD (1 Mar 2006). Author weblink.
  • Botto M. What knockout mice have taught us about the pathogenesis of lupus. Annual European Congress of Rheumatology, 8 Jun 2005 - 11 Jun 2005. 64:53-53. B M J PUBLISHING GROUP (1 Jul 2005). Author weblink.
  • Haskard DO; Bhatia V; Boyle JJ; Mason JC; Botto M. Role of complement and complement regulatory proteins in atherosclerosis. 75th Congress of the European-Atherosclerosis-Society, 23 Apr 2005 - 26 Apr 2005. 6:39-39. ELSEVIER IRELAND LTD (1 Apr 2005). Author weblink DOI.
  • Turnberg D; Botto M; Warren J; Zhou WD; Sacks SH; Morgan P; Walport MJ; Cook T. CD59a deficiency exacerbates adriamycin nephropathy and ischaemia-reperfusion injury in mice. 36th Annual Meeting of the American-Society-of-Nephrology, 12 Nov 2003 - 17 Nov 2003. 14:163A-163A. LIPPINCOTT WILLIAMS & WILKINS (1 Nov 2003). Author weblink.
  • Trendelenburg M; Hernandes-Cortes J; Walport SIMJ; Cook HT; Fossati-Jimack L; Botto M. The role of complement in cryoglobulin-induced immune complex glomerulonephritis. 9th European Meeting on Complement in Human Disease, 6 Sep 2003 - 9 Sep 2003. 40:192-192. PERGAMON-ELSEVIER SCIENCE LTD (1 Sep 2003). Author weblink.
  • Tenner AJ; Fonseca MI; Botto M; Li M; Faraji H; Pisalyaput K; Galvan M. Influence of complement on neurotoxicity in models of Alzheimer's disease. 34th Annual Meeting of the American-Society-for-Neurochemistry, 3 May 2003 - 7 May 2003. 85:88-88. BLACKWELL PUBLISHING LTD (1 May 2003). Author weblink.
  • Ten VS; Mazer SP; Minamoto K; Fedarau MA; Ratner VI; Botto M; Pinsky DJ. Genetic deficiency of the complement component C1q protects neonatal mice against hypoxic ischemic encephalopathy (HIE). Annual Meeting of the Pediatric-Academic-Society, 3 May 2003 - 6 May 2003. 53:541A-541A. INT PEDIATRIC RESEARCH FOUNDATION, INC (1 Apr 2003). Author weblink.
  • Yamada M; Oritani K; Kaisho T; Ishikawa J; Yoshida H; Takahashi I; Kawamoto S; Ishida N; et alUjiie H; Masaie H; Botto M; Tomiyama Y; Matsuzawa Y. Complement C1q suppresses lipopolysaccharide-induced cytokine production in bone marrow derived dendritic cells. 44th Annual Meeting of the American-Society-of-Hematology, 6 Dec 2002 - 10 Dec 2002. 100:462A-462A. AMER SOC HEMATOLOGY (16 Nov 2002). Author weblink.
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