Dr Mark Griffiths

Publications


Journals

  • Price LC; McAuley DF; Marino PS; Finney SJ; Griffiths MJ; Wort SJ. (May 2012). Pathophysiology of pulmonary hypertension in acute lung injury. Am J Physiol Lung Cell Mol Physiol. 302:L803-L815. DOI.
  • Bloch S; Polkey MI; Griffiths M; Kemp P. (Apr 2012). Molecular mechanisms of intensive care unit-acquired weakness. Eur Respir J. 39:1000-1011. DOI.
  • Proudfoot AG; Hind M; Griffiths MJ. (2011). Biomarkers of acute lung injury: worth their salt?. BMC Med. 9:132. DOI.
  • Price LC; McAuley DF; Marino PS; Finney SJ; Griffiths MJ; Wort SJ. (13 Jan 2012). Pathophysiology of pulmonary hypertension in acute lung injury. Am J Physiol Lung Cell Mol Physiol. DOI.
  • Noah MA; Peek GJ; Finney SJ; Griffiths MJ; Harrison DA; Grieve R; Sadique MZ; Sekhon JS; et alMcAuley DF; Firmin RK; Harvey C; Cordingley JJ; Price S; Vuylsteke A; Jenkins DP; Noble DW; Bloomfield R; Walsh TS; Perkins GD; Menon D; Taylor BL. (19 Oct 2011). Referral to an extracorporeal membrane oxygenation center and mortality among patients with severe 2009 influenza A(H1N1). JAMA: Journal of the American Medical Association. 306:1659-1668.
  • Proudfoot AG; McAuley DF; Hind M; Griffiths MJD. (1 Oct 2011). Translational research: what does it mean, what has it delivered and what might it deliver?. CURRENT OPINION IN CRITICAL CARE. 17:495-503. Author weblink DOI.
  • Davidson SJ; Riddell A; Tillyer L; Finney SJ; Cordingley JJ; Griffiths MJ. (1 Jul 2011). Von Willebrand factor (VWF) antigen and VWF pro-peptide as biomarkers of acute lung injury in H1N1. JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 9:238-238. Author weblink.
  • Mumby S; Chung KF; McCreanor JE; Moloney ED; Griffiths MJD; Quinlan GJ. (1 Sep 2011). Pro-oxidant iron in exhaled breath condensate: A potential excretory mechanism. RESPIRATORY MEDICINE. 105:1290-1295. DOI.
  • Proudfoot AG; McAuley DF; Hind M; Griffiths MJ. (Oct 2011). Translational research: what does it mean, what has it delivered and what might it deliver?. Curr Opin Crit Care. 17:495-503. DOI.
  • Trimlett RH; Cordingley JJ; Griffiths MJ; Price S; Hunter DN; Finney SJ. (Jun 2011). A modified technique for insertion of dual lumen bicaval cannulae for venovenous extracorporeal membrane oxygenation. Intensive Care Med. 37:1036-1037. DOI.
  • Mumby S; Chung KF; McCreanor JE; Moloney ED; Griffiths MJ; Quinlan GJ. (Sep 2011). Pro-oxidant iron in exhaled breath condensate: a potential excretory mechanism. Respir Med. 105:1290-1295. DOI.
  • Proudfoot AG; McAuley DF; Griffiths MJ; Hind M. (Mar 2011). Human models of acute lung injury. Dis Model Mech. 4:145-153. DOI.
  • Griffiths MJ; Finney SJ. (Jan 2011). Small steps in the right direction for ventilator-induced lung injury: Prevention, prevention, prevention!. Crit Care Med. 39:196-197. DOI.
  • Bastin AJ; Sato H; Davidson SJ; Quinlan GJ; Griffiths MJ. (Jan 2011). Biomarkers of lung injury after one-lung ventilation for lung resection. Respirology. 16:138-145. DOI.
  • Gordon SE; Cartwright N; Griffiths MJ. (Oct 2009). Investigation of endothelial function by pulse contour analysis: a protocol for drug administration and timing of pulse contour assessment. Br J Clin Pharmacol. 68:630-633. DOI.
  • Roca O; Gomez-Olles S; Cruz M-J; Munoz X; Griffiths MJD; Masclans JR. (1 Jun 2010). Mechanical ventilation induces changes in exhaled breath condensate of patients without lung injury. RESPIRATORY MEDICINE. 104:822-828. DOI.
  • Finney SJ; Cordingley JJ; Griffiths MJ; Evans TW. (Mar 2010). ECMO in adults for severe respiratory failure finally comes of age: just in time?. Thorax. 65:194-195. DOI.
  • Charron CE; Chou P-C; Coutts DJC; Kumar V; To M; Akashi K; Pinhu L; Griffiths M; et alAdcock IM; Barnes PJ; Ito K. (25 Dec 2009). Hypoxia-inducible Factor 1 alpha Induces Corticosteroid-insensitive Inflammation via Reduction of Histone Deacetylase-2 Transcription. JOURNAL OF BIOLOGICAL CHEMISTRY. 284:36047-36054. Author weblink DOI.
  • Creagh-Brown BC; Griffiths MJD; Evans TW. (1 Jan 2009). Bench-to-bedside review: Inhaled nitric oxide therapy in adults. CRITICAL CARE. 13. Author weblink DOI.
  • Stirling SL; Cordingley JJ; Hunter DN; Griffiths MJ; Wort SJ; Evans TW; Finney SJ. (Aug 2009). Extracorporeal carbon dioxide removal to "protect" the lung. Thorax. 64:726-727. DOI.
  • Griffiths MJ; McAuley DF. (Dec 2008). RAGE: a biomarker for acute lung injury. Thorax. 63:1034-1036. DOI.
  • Callister ME; Pinhu L; Catley MC; Westwell AD; Newton R; Leaver SK; Quinlan GJ; Evans TW; et alGriffiths MJ; Burke-Gaffney A. (1 Nov 2008). PMX464, a thiol-reactive quinol and putative thioredoxin inhibitor, inhibits NF-kappa B-dependent proinflammatory activation of alveolar epithelial cells. BRITISH JOURNAL OF PHARMACOLOGY. 155:661-672. Author weblink DOI.
  • Pinhu L; Park JES; Yao W; Griffiths MJD. (1 Nov 2008). Reference gene selection for real-time polymerase chain reaction in human lung cells subjected to cyclic mechanical strain. RESPIROLOGY. 13:990-999. Author weblink DOI.
  • Tang SS; Redmond K; Griffiths M; Ladas G; Goldstraw P; Dusmet M. (Oct 2008). The mortality from acute respiratory distress syndrome after pulmonary resection is reducing: a 10-year single institutional experience. Eur J Cardiothorac Surg. 34:898-902. DOI.
  • Roca O; Gomez-Olles S; Cruz M-J; Munoz X; Griffiths MJD; Masclans JR. (1 Jan 2008). Effects of salbutamol on exhaled breath condensate biomarkers in acute lung injury: prospective analysis. CRITICAL CARE. 12. Author weblink DOI.
  • Dulic-Sills A; Blunden MJ; Mawdsley J; Bastin AJ; McAuley D; Griffiths M; Rampton DS; Yaqoob MM; et alMacey MG; Agrawal SG. (20 Oct 2006). New flow cytometric technique for the evaluation of circulating endothelial progenitor cell levels in various disease groups. JOURNAL OF IMMUNOLOGICAL METHODS. 316:107-115. Author weblink DOI.
  • Curzen NP; Griffiths MJ; Evans TW. (Jun 1995). Contraction to endothelin-1 in pulmonary arteries from endotoxin-treated rats is modulated by endothelium. Am J Physiol. 268:H2260-H2266.
  • Curzen NP; Kaddoura S; Griffiths MJ; Evans TW. (May 1997). Endothelin-1 in rat endotoxemia: mRNA expression and vasoreactivity in pulmonary and systemic circulations. Am J Physiol. 272:H2353-H2360.
  • Griffiths MJD; Evans TW. (22 Dec 2005). Drug therapy - Inhaled nitric oxide therapy in adults. NEW ENGLAND JOURNAL OF MEDICINE. 353:2683-2695. Author weblink DOI.
  • Griffiths MJ; Evans TW. (22 Dec 2005). Inhaled nitric oxide therapy in adults. N Engl J Med. 353:2683-2695. DOI.
  • MESSENT M; GRIFFITHS MJD. (1 Aug 1992). PHARMACOTHERAPY IN LUNG INJURY. THORAX. 47:651-656. Author weblink DOI.
  • MESSENT M; QUINLAN GJ; GRIFFITHS MJD; GUTTERIDGE JMC; EVANS TW. (1 Apr 1993). CHARACTERIZATION OF ISCHEMIA/REPERFUSION DAMAGE IN AN ISOLATED-PERFUSED RAT LUNG. AMERICAN REVIEW OF RESPIRATORY DISEASE. 147:A931-A931. Author weblink.
  • MESSENT M; GRIFFITHS MJD; EVANS TW. (1 Apr 1993). AUGMENTATION OF THE PULMONARY VASCULAR-RESPONSE TO HYPOXIA IN ISCHEMIC-REPERFUSED LUNG. AMERICAN REVIEW OF RESPIRATORY DISEASE. 147:A931-A931. Author weblink.
  • CURZEN NP; GRIFFITHS MJD; EVANS TW. (1 Apr 1994). ROLE OF THE ENDOTHELIUM IN MODULATING THE VASCULAR-RESPONSE TO SEPSIS. CLINICAL SCIENCE. 86:359-374. Author weblink.
  • Park JES; Griffiths MJD. (1 Sep 2005). Recent advances in mechanical ventilation. CLINICAL MEDICINE. 5:441-444.
  • Messent M; Griffiths MJ. (Aug 1992). The pulmonary physician and critical care. 3. Pharmacotherapy in lung injury. Thorax. 47:651-656.
  • Messent M; Griffiths MJ; Evans TW. (Jul 1993). Pulmonary vascular reactivity and ischaemia-reperfusion injury in the rat. Clin Sci (Lond). 85:71-75.
  • Griffiths MJ; Liu S; Curzen NP; Messent M; Evans TW. (Mar 1995). In vivo treatment with endotoxin induces nitric oxide synthase in rat main pulmonary artery. Am J Physiol. 268:L509-L518.
  • Griffiths MJ; Messent M; Curzen NP; Evans TW. (Nov 1995). Aminoguanidine selectively decreases cyclic GMP levels produced by inducible nitric oxide synthase. Am J Respir Crit Care Med. 152:1599-1604.
  • Messent M; Griffiths MJ; Quinlan GJ; Gutteridge JM; Evans TW. (Jan 1996). Ischaemia--reperfusion injury in the rat is modulated by superoxide generation and leads to an augmentation of the hypoxic pulmonary vascular response. Clin Sci (Lond). 90:47-54.
  • Curzen NP; Mitchell JA; Jourdan KB; Griffiths MJ; Evans TW. (Dec 1996). Endothelin-1-induced contraction of pulmonary arteries from endotoxemic rats is attenuated by the endothelin-A receptor antagonist, BQ123. Crit Care Med. 24:2007-2013.
  • Griffiths MJ; Curzen NP; Mitchell JA; Evans TW. (Aug 1997). In vivo treatment with endotoxin increases rat pulmonary vascular contractility despite NOS induction. Am J Respir Crit Care Med. 156:654-658.
  • Moloney ED; Mumby SE; Gajdocsi R; Cranshaw JH; Kharitonov SA; Quinlan GJ; Griffiths MJ. (1 Jan 2004). Exhaled breath condensate detects markers of pulmonary inflammation after cardiothoracic surgery. Am J Respir Crit Care Med. 169:64-69. DOI.
  • Moloney ED; Griffiths MJ. (Feb 2004). Protective ventilation of patients with acute respiratory distress syndrome. Br J Anaesth. 92:261-270.
  • Callister ME; Griffiths MJ; Nicholson AG; Leonard A; Johnson EM; Polkey MI; Kerr JR. (Sep 2004). A fatal case of disseminated aspergillosis caused by a non-sporulating strain of Aspergillus fumigatus. J Clin Pathol. 57:991-992. DOI.
  • Griffiths MJ; Bonnet D; Janes SM. (16 Jul 2005). Stem cells of the alveolar epithelium. Lancet. 366:249-260. DOI.
  • Albera C; Polak JM; Janes S; Griffiths MJ; Alison MR; Wright NA; Navaratnarasah S; Poulsom R; et alJeffery R; Fisher C; Burke M; Bishop AE. (Jul 2005). Repopulation of human pulmonary epithelium by bone marrow cells: a potential means to promote repair. Tissue Eng. 11:1115-1121. DOI.
  • Pinhu L; Whitehead T; Evans T; Griffiths M. (25 Jan 2003). Ventilator-associated lung injury. LANCET. 361:332-340. Author weblink DOI.
  • Morgan JM; Griffiths M; du Bois RM; Evans TW. (Mar 1991). Hypoxic pulmonary vasoconstriction in systemic sclerosis and primary pulmonary hypertension. Chest. 99:551-556.
  • Cranshaw J; Griffiths MJ; Evans TW. (Sep 2002). The pulmonary physician in critical care - part 9: non-ventilatory strategies in ARDS. Thorax. 57:823-829.
  • Griffiths MJ; Evans TW. (Jan 2002). The pulmonary physician in critical care: towards comprehensive critical care?. Thorax. 57:77-78.
  • Dakin J; Griffiths M. (Jan 2002). The pulmonary physician in critical care 1: pulmonary investigations for acute respiratory failure. Thorax. 57:79-85.
  • Pittet JF; Griffiths MJ; Geiser T; Kaminski N; Dalton SL; Huang X; Brown LA; Gotwals PJ; et alKoteliansky VE; Matthay MA; Sheppard D. (Jun 2001). TGF-beta is a critical mediator of acute lung injury. J Clin Invest. 107:1537-1544. DOI.

Conferences

  • Ng-Blichfeldt JP; Griffiths M; Griesenbach U; Allen B; Hind M. THE ROLE OF THE RETINOIC ACID PATHWAY IN HUMAN LUNG REGENERATION. Winter Meeting of the British-Thoracic-Society, 7 Dec 2011 - 9 Dec 2011. 66:A115-A115. B M J PUBLISHING GROUP (1 Dec 2011). DOI.
  • McAuley DF; O'Kane C; Griffiths MJD. A stepwise approach to justify phase III randomized clinical trials and enhance the likelihood of a positive result. Conference on Thinking Outside the Box, Mar 2010. 38:S523-S527. LIPPINCOTT WILLIAMS & WILKINS (1 Oct 2010). Author weblink DOI.
  • Park JES; Lyon AR; Hector LR; Griffiths MJD. MECHANICAL STRAIN AT THE PULMONARY MICROVASCULATURE INDUCES MONOCYTE CHEMOATTRACTANT PROTEIN-1 WHICH CONTRIBUTES TO PULMONARY INFLAMMATION AND REMODELLING IN CHRONIC HEART FAILURE. Winter Meeting of the British-Thoracic-Society, 2 Dec 2009 - 4 Dec 2009. 64:A58-A58. B M J PUBLISHING GROUP (1 Dec 2009). Author weblink DOI.
  • Bastin AJ; Griffiths MJD. BIOMARKERS OF LUNG INJURY IN PLASMA AND EXHALED BREATH CONDENSATE AFTER ONE-LUNG VENTILATION FOR LUNG RESECTION. Winter Meeting of the British-Thoracic-Society, 3 Dec 2008 - 5 Dec 2008. 63:A142-A142. B M J PUBLISHING GROUP (1 Dec 2008). Author weblink.
  • Park JES; Lyon AR; Harding SE; Griffiths MJD. MECHANICAL STIMULATION OF HUMAN LUNG MICROVASCULAR ENDOTHELIAL CELLS CAUSES REMODELLING OF THE ALVEOLAR-CAPILLARY MEMBRANE AND DYSPNOEA IN CHRONIC HEART FAILURE. Winter Meeting of the British-Thoracic-Society, 3 Dec 2008 - 5 Dec 2008. 63:A27-A28. B M J PUBLISHING GROUP (1 Dec 2008). Author weblink.
  • Tang SSK; Redmond K; Griffiths M; Ladas G; Gotdstraw P; Dusmet M. The mortality from acute respiratory distress syndrome after pulmonary resection is reducing: a 10-year single institutional experience. 21st Annual Meeting of the European-Association-for-Cardio-Thoracic-Surgery, 16 Sep 2007 - 19 Sep 2007. 34:898-902. ELSEVIER SCIENCE BV (1 Oct 2008). Author weblink DOI.
  • Pinhu L; Wilson M; Takata M; Griffiths M. Cyclo-oxygenase-2 induction by cyclic mechanical strain in human primary alveolar type 2 cells and in murine whole lung is dependent on activation of erk1/2. Winter Meeting of the British-Thoracic-Society. 62:A60-A61. (Dec 2007).
  • Doffman SR; Griffiths LJ; Athorn GR; Vinnicombe SJ; Moore-Gillon JC; Griffiths MJ; Agrawal SG. Galactomannan detection in exhaled breath condensate of neutropenic patients with suspected invasive pulmonary aspergillosis. Winter Meeting of the British-Thoracic-Society, 5 Dec 2007 - 7 Dec 2007. 62:A50-A51. B M J PUBLISHING GROUP (1 Dec 2007). Author weblink.
  • Moloney ED; Mumby S; Gajdocsi R; Cranshaw JH; Kharitonov SA; Quinlan GJ; Griffiths MJD. Exhaled breath condensate compared to broncho-alveolar lavage for detecting lung inflammation induced by cardiothoracic surgery. Winter Meeting of the British Thoracic-Society. 58:36-36. (Dec 2003).
  • Gordon SE; Griffiths MJ. Remote ischaemic preconditioning protect against experimental or induced inflammation in humans. 36th Critical Care Congress of the Society-of-Critical-Care-Medicine, 18 Feb 2007 - 21 Feb 2007. 34:A111-A111. LIPPINCOTT WILLIAMS & WILKINS (1 Dec 2006). Author weblink DOI.
  • Pinhu L; Griffiths MJD. Mitochondrial reactive oxygen species are required for mechanical strain-induced interleukin-8 production by lung epithelial cells. Winter Meeting of the British-Thoracic-Society/British-Lung-Foundation (BTS/BLF), 6 Dec 2006 - 8 Dec 2006. 61:II52-II52. B M J PUBLISHING GROUP (1 Dec 2006). Author weblink.
  • Ward CH; Bloom C; Griffiths MJD; Thomas SR. Outcomes of cystic fibrosis patients undergoing invasive ventilation on the intensive care unit. Winter Meeting of the British-Thoracic-Society, 2005. 60:II28-II28. B M J PUBLISHING GROUP (1 Dec 2005). Author weblink.
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