Professor Mary J Morrell

Publications


Journals

  • Papaioannou I; Twigg GL; Kemp M; Roughton M; Hooper J; Morrell MJ; Polkey MI. (Feb 2012). Melatonin concentration as a marker of the circadian phase in patients with obstructive sleep apnoea. Sleep Med. 13:167-171. DOI.
  • Papaioannou I; Patterson M; Twigg GL; Vazir A; Ghatei M; Morrell MJ; Polkey MI. (15 Oct 2011). Lack of association between impaired glucose tolerance and appetite regulating hormones in patients with obstructive sleep apnea. J Clin Sleep Med. 7:486-92B. DOI.
  • Morrell MJ; Glasser M. (15 May 2011). The Brain in Sleep-Disordered Breathing A Vote for the Chicken?. AM J RESP CRIT CARE. 183:1292-1294. DOI.
  • Simonds AK; Hanak A; Chatwin M; Morrell M; Hall A; Parker KH; Siggers JH; Dickinson RJ. (Oct 2010). Evaluation of droplet dispersion during non-invasive ventilation, oxygen therapy, nebuliser treatment and chest physiotherapy in clinical practice: implications for management of pandemic influenza and other airborne infections. Health Technol Assess. 14:131-172. DOI.
  • Morrell MJ; Jackson ML; Twigg GL; Ghiassi R; McRobbie DW; Quest RA; Pardoe H; Pell GS; et alAbbott DF; Rochford PD; Jackson GD; Pierce RJ; O'Donoghue FJ; Corfield DR. (Oct 2010). Changes in brain morphology in patients with obstructive sleep apnoea. Thorax. 65:908-914. DOI.
  • Twigg GL; Papaioannou I; Jackson M; Ghiassi R; Shaikh Z; Jaye J; Graham KS; Simonds AK; et alMorrell MJ. (1 Jul 2010). Obstructive sleep apnea syndrome is associated with deficits in verbal but not visual memory. Am J Respir Crit Care Med. 182:98-103. DOI.
  • Freilich S; Goff EA; Malaweera AS; Twigg GL; Simonds AK; Mathias CJ; Morrell MJ. (Jan 2010). Sleep architecture and attenuated heart rate response to arousal from sleep in patients with autonomic failure. Sleep Med. 11:87-92. DOI.
  • Goff EA; Nicholas CL; Simonds AK; Trinder J; Morrell MJ. (Mar 2010). Differential effects of waking from non-rapid eye movement versus rapid eye movement sleep on cardiovascular activity. J Sleep Res. 19:201-206. DOI.
  • Peppard PE; Ward NR; Morrell MJ. (15 Oct 2009). The Impact of Obesity on Oxygen Desaturation during Sleep-disordered Breathing. AM J RESP CRIT CARE. 180:788-793. DOI.
  • Goff EA; Nicholas CL; Malaweera AS; Simonds AK; Trinder J; Morrell MJ. (Jun 2010). The influence of age on heart rate variability during morning wakefulness. Clin Auton Res. 20:175-182. DOI.
  • Jaye J; Chatwin M; Dayer M; Morrell MJ; Simonds AK. (Mar 2009). Autotitrating versus standard noninvasive ventilation: a randomised crossover trial. Eur Respir J. 33:566-571. DOI.
  • Nickol AH; Dunroy H; Polkey MI; Simonds A; Cordingley J; Corfield DR; Morrell MJ. (Feb 2009). A quick and easy method of measuring the hypercapnic ventilatory response in patients with COPD. RESP MED. 103:258-267. DOI.
  • Chatwin M; Nickol AH; Morrell MJ; Polkey MI; Simonds AK. (Nov 2008). Randomised trial of inpatient versus outpatient initiation of home mechanical ventilation in patients with nocturnal hypoventilation. RESP MED. 102:1528-1535. DOI.
  • Hastings PC; Vazir A; Meadows GE; Dayer M; Poole-Wilson PA; McIntyre HF; Morrell MJ; Cowie MR; et alSimonds AK. (18 Feb 2010). Adaptive servo-ventilation in heart failure patients with sleep apnea: a real world study. Int J Cardiol. 139:17-24. DOI.
  • Morrell MJ. (1 Sep 2008). Going to the movies can make all the difference. J PHYSIOL-LONDON. 586:4035-4035. DOI.
  • Vazir A; Hastings PC; Morrell MJ; Pepper J; Henein MY; Westaby S; Poole-Wilson PA; Cowie MR; et alSimonds AK. (4 Feb 2010). Resolution of central sleep apnoea following implantation of a left ventricular assist device. Int J Cardiol. 138:317-319. DOI.
  • Goff EA; O'Driscoll DM; Simonds AK; Trinder J; Morrell MJ. (1 Jul 2008). The cardiovascular response to arousal from sleep decreases with age in healthy adults. SLEEP. 31:1009-1017.
  • Vazir A; Hastings PC; Papaioannou I; Poole-Wilson PA; Cowie MR; Morrell MJ; Simonds AK. (Jun 2008). Variation in severity and type of sleep-disordered breathing throughout 4 nights in patients with heart failure. RESP MED. 102:831-839. DOI.
  • Morrell MJ; Meadows GE; Hastings P; Vazir A; Kostikas K; Simonds AK; Corfield DR. (May 2007). The effects of adaptive servo ventilation on cerebral vascular reactivity in patients with congestive heart failure and sleep-disordered breathing. Sleep. 30:648-653.
  • Vazir A; Hastings PC; Dayer M; McIntyre HF; Henein MY; Poole-Wilson PA; Cowie MR; Morrell MJ; et alSimonds AK. (Mar 2007). A high prevalence of sleep disordered breathing in men with mild symptomatic chronic heart failure due to left ventricular systolic dysfunction. Eur J Heart Fail. 9:243-250. DOI.
  • Nickol AH; Leverment J; Richards P; Seal P; Harris GA; Cleland J; Dubowitz G; Collier DJ; et alMilledge J; Stradling JR; Morrell MJ. (Dec 2006). Temazepam at high altitude reduces periodic breathing without impairing next-day performance: a randomized cross-over double-blind study. J SLEEP RES. 15:445-454.
  • Vazir A; Morrell MJ; Simonds AK. (Aug 2006). Heart rate variation analysis may not effectively detect sleep apnoeas in heart failure. EUR RESPIR J. 28:458-458. DOI.
  • Kostikas K; Browne HA; Ghiassi R; Adams L; Simonds AK; Morrell MJ. (Jul 2006). The determinants of therapeutic levels of continuous positive airway pressure in elderly sleep apnea patients. Respir Med. 100:1216-1225. DOI.
  • Szollosi I; O'Driscoll DM; Dayer MJ; Coats AJ; Morrell MJ; Simonds AK. (Jun 2006). Adaptive servo-ventilation and deadspace: effects on central sleep apnoea. J Sleep Res. 15:199-205. DOI.
  • Hastings PC; Vazir A; O'Driscoll DM; Morrell MJ; Simonds AK. (Apr 2006). Symptom burden of sleep-disordered breathing in mild-to-moderate congestive heart failure patients. Eur Respir J. 27:748-755. DOI.
  • Rao A; Georgiadou P; Francis DP; Johnson A; Kremastinos DT; Simonds AK; Coats AJS; Cowley A; et alMorrell MJ. (Mar 2006). Sleep-disordered breathing in a general heart failure population: relationships to neurohumoral activation and subjective symptoms. J SLEEP RES. 15:81-88.
  • Vazir A; Dayer M; Hastings PC; McIntyre HF; Henein MY; Poole-Wilson PA; Cowie MR; Morrell MJ; et alSimonds AK. (Mar 2006). Can heart rate variation rule out sleep-disordered breathing in heart failure?. Eur Respir J. 27:571-577. DOI.
  • Morrell MJ; Twigg G. (2006). Neural consequences of sleep disordered breathing: the role of intermittent hypoxia. Adv Exp Med Biol. 588:75-88.
  • Thomson S; Morrell MJ; Cordingley JJ; Semple SJ. (Nov 2005). Ventilation is unstable during drowsiness before sleep onset. J Appl Physiol. 99:2036-2044. DOI.
  • Meadows GE; Kotajima F; Vazir A; Kostikas K; Simonds AK; Morrell MJ; Corfield DR. (Nov 2005). Overnight changes in the cerebral vascular response to isocapnic hypoxia and hypercapnia in healthy humans: protection against stroke. Stroke. 36:2367-2372. DOI.
  • Kotajima F; Meadows GE; Morrell MJ; Corfield DR. (1 Oct 2005). Cerebral blood flow changes associated with fluctuations in alpha and theta rhythm during sleep onset in humans. J PHYSIOL-LONDON. 568:305-313. DOI.
  • O'Driscoll DM; Morrell MJ. (15 Jun 2005). The interaction between respiratory and autonomic function during sleep-related changes in pharyngeal airway patency. Auton Neurosci. 120:18-25. DOI.
  • Pattinson KTS; Bowes M; Wise RG; Parkes MJ; Morrell MJ. (May 2005). Evaluation of a non-invasive method of assessing opioid induced respiratory depression. ANAESTHESIA. 60:426-432.
  • O'Driscoll DM; Kostikas K; Simonds AK; Morrell MJ. (Apr 2005). Occlusion of the upper airway does not augment the cardiovascular response to arousal from sleep in humans. J Appl Physiol. 98:1349-1355. DOI.
  • Meadows GE; O'Driscoll DM; Simonds AK; Morrell MJ; Corfield DR. (Oct 2004). Cerebral blood flow response to isocapnic hypoxia during slow-wave sleep and wakefulness. J Appl Physiol. 97:1343-1348. DOI.
  • Szollosi I; Jones M; Morrell MJ; Helfet K; Coats AJ; Simonds AK. (Sep 2004). Effect of CO2 inhalation on central sleep apnea and arousals from sleep. Respiration. 71:493-498. DOI.
  • Polkey MI; Morrell MJ; Simonds AK. (Apr 2004). Apnea and history. CHEST. 125:1587-1588.
  • Morrell MJ. (15 Mar 2004). Residual sleepiness in patients with optimally treated sleep apnea: a case for hypoxia-induced oxidative brain injury. SLEEP. 27:186-187.
  • O'Driscoll DM; Meadows GE; Corfield DR; Simonds AK; Morrell MJ. (Mar 2004). Cardiovascular response to arousal from sleep under controlled conditions of central and peripheral chemoreceptor stimulation in humans. J Appl Physiol. 96:865-870. DOI.
  • Bennett JR; Dunroy HM; Corfield DR; Hart N; Simonds AK; Polkey MI; Morrell MJ. (13 Jan 2004). Respiratory muscle activity during REM sleep in patients with diaphragm paralysis. Neurology. 62:134-137.
  • Browne HA; Adams L; Simonds AK; Morrell MJ. (Oct 2003). Sleep apnoea and daytime function in the elderly--what is the impact of arousal frequency?. Respir Med. 97:1102-1108.
  • Morrell MJ; McRobbie DW; Quest RA; Cummin AR; Ghiassi R; Corfield DR. (Sep 2003). Changes in brain morphology associated with obstructive sleep apnea. Sleep Med. 4:451-454.
  • Dunroy HM; Adams L; Corfield DR; Morrell MJ. (16 Jul 2003). CO2 retention in lung disease; could there be a pre-existing difference in respiratory physiology. Respir Physiol Neurobiol. 136:179-186.
  • Meadows GE; Dunroy HM; Morrell MJ; Corfield DR. (Jun 2003). Hypercapnic cerebral vascular reactivity is decreased, in humans, during sleep compared with wakefulness. J Appl Physiol. 94:2197-2202. DOI.
  • Browne HA; Adams L; Simonds AK; Morrell MJ. (Mar 2003). Ageing does not influence the sleep-related decrease in the hypercapnic ventilatory response. Eur Respir J. 21:523-529.
  • Morrell MJ; Arabi Y; Zahn BR; Meyer KC; Skatrud JB; Badr MS. (Aug 2002). Effect of surfactant on pharyngeal mechanics in sleeping humans: implications for sleep apnoea. Eur Respir J. 20:451-457.
  • Morrell MJ; Heywood P; Moosavi SH; Stevens J; Guz A. (Dec 2001). Central chemosensitivity and breathing asleep in unilateral medullary lesion patients: comparisons to animal data. Respir Physiol. 129:269-277.
  • Browne HA; Adams L; Simonds AK; Morrell MJ. (Mar 2001). Impact of age on breathing and resistive pressure in people with and without sleep apnea. J Appl Physiol. 90:1074-1082.
  • Morrell MJ; Finn L; Kim H; Peppard PE; Badr MS; Young T. (Dec 2000). Sleep fragmentation, awake blood pressure, and sleep-disordered breathing in a population-based study. AM J RESP CRIT CARE. 162:2091-2096.
  • Morrell MJ; Browne HA; Adams L. (1 Jul 2000). The respiratory response to inspiratory resistive loading during rapid eye movement sleep in humans. J Physiol. 526 Pt 1:195-202.
  • Morrell MJ; Guz A. (Jul 2000). Unilateral focal lesions in the rostrolateral medulla influence chemosensitivity and breathing measured during wakefulness, sleep, and exercise - Reply. J NEUROL NEUROSUR PS. 69:139-139.
  • Morrell MJ; Heywood P; Moosavi SH; Guz A; Stevens J. (Nov 1999). Unilateral focal lesions in the rostrolateral medulla influence chemosensitivity and breathing measured during wakefulness, sleep, and exercise. J Neurol Neurosurg Psychiatry. 67:637-645.
  • Morrell MJ; Arabi Y; Zahn B; Badr MS. (Dec 1998). Progressive retropalatal narrowing preceding obstructive apnea. AM J RESP CRIT CARE. 158:1974-1981.
  • Morrell MJ; Badr MS. (Jan 1998). Effects of NREM sleep on dynamic within-breath changes in upper airway patency in humans. J APPL PHYSIOL. 84:190-199.
  • Heywood P; Murphy K; Corfield DR; Morrell MJ; Howard RS; Guz A. (Oct 1996). Control of breathing in man; insights from the 'locked-in' syndrome. Respir Physiol. 106:13-20.
  • Morrell MJ; Harty HR; Adams L; Guz A. (Jul 1996). Breathing during wakefulness and NREM sleep in humans without an upper airway. J Appl Physiol. 81:274-281.
  • Corfield DR; Morrell MJ; Guz A. (Aug 1995). The nature of breathing during hypocapnia in awake man. Respir Physiol. 101:145-159.
  • Innes JA; Morrell MJ; Kobayashi I; Hamilton RD; Guz A. (Jun 1995). Central and reflex neural control of genioglossus in subjects who underwent laryngectomy. J Appl Physiol. 78:2180-2186.
  • Morrell MJ; Harty HR; Adams L; Guz A. (Apr 1995). Changes in total pulmonary resistance and PCO2 between wakefulness and sleep in normal human subjects. J Appl Physiol. 78:1339-1349.
  • Horner RL; Innes JA; Morrell MJ; Shea SA; Guz A. (1 Apr 1994). The effect of sleep on reflex genioglossus muscle activation by stimuli of negative airway pressure in humans. J Physiol. 476:141-151.
  • Morrell MJ; Shea SA; Adams L; Guz A. (Jul 1993). Effects of inspiratory support upon breathing in humans during wakefulness and sleep. Respir Physiol. 93:57-70.

Chapters in books

  • Morrell MJ; Dempsey JA. Impact of sleep on ventilation. In Breathing disorders in sleep. 3-17. (2002).
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